Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
TMPRSS2/ERG fusion resulting in ERG overexpression occurs in 30 to 50% of prostate cancer (PCa) in Caucasian patients, but its prognostic relevance remains controversial. In the present study, we investigated ERG expression in all stages of PCa progression, and evaluated the prognostic impact of ERG status in clinically localized PCa (CLC) and in castration resistant disease (CRPC). ERG and AR expressions were evaluated by immunohistochemistry on tissue microarrays containing samples of high grade PIN (n = 57), CLC surgically treated (n = 299, including 185 Caucasians and 114 African-Caribbeans), metastases (n = 17), and CRPC (n = 41). In Caucasians, ERG expression significantly increased from high grade PIN (17.5%) to pT2 (27%) and pT3 CLC (43%), then to metastases (53%). In CLC, stainings for ERG and AR were correlated, and ERG expression was less frequent in African-Caribbeans compared to Caucasians (11.5% vs. 33%). In Caucasians CLC, ERG was associated with longer recurrence free survival, after adjusting for classical prognostic markers. In CRPC, ERG was expressed in 29% of cases, and was associated with a longer overall survival. Our results confirm that ERG expression is less frequent in PCa from patients of African descent. Although ERG expression increases during PCa natural history, positive ERG status is associated with better outcome in both CLC and CRPC. This paradox could be explained in part by the fact that ERG expression is AR dependant, then ERG positive cancers are likely to progress in a rich androgen environment, with a better response to androgen suppression.
ISSN: 0270-4137

hal-01118555
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118555
DOI : 10.1002/pros.22863
PUBMED : 25175352

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Necroptosis is a programmed cell death pathway that has been shown to be of central pathophysiological relevance in multiple disorders (hepatitis, brain and cardiac ischemia, pancreatitis, viral infection and inflammatory diseases). Necroptosis is driven by two serine threonine kinases, RIPK1 (Receptor Interacting Protein Kinase 1) and RIPK3, and a pseudo-kinase MLKL (Mixed Lineage Kinase domain-Like) associated in a multi-protein complex called necrosome. In order to find new inhibitors for use in human therapy, a chemical library containing highly diverse chemical structures was screened using a cell-based assay. The compound 6E11, a natural product derivative, was characterized as a positive hit. Interestingly, this flavanone compound: inhibits necroptosis induced by death receptors ligands TNF-α (Tumor Necrosis Factor) or TRAIL (TNF-Related Apoptosis-Inducing Ligand); is an extremely selective inhibitor, among kinases, of human RIPK1 enzymatic activity with a nM Kd; has a non-ATP competitive mode of action and a novel putative binding site; is weakly cytotoxic towards human primary blood leukocytes or retinal pigment epithelial cells at effective concentrations; protects human aortic endothelial cells (HAEC) from cold hypoxia/reoxygenation injury more effectively than necrostatin-1 (Nec-1) and Nec-1s. Altogether, these data demonstrate that 6E11 is a novel potent small molecular inhibitor of RIPK1-driven necroptosis.
ISSN: 2045-2322

hal-01616456
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456/file/s41598-017-12788-4.pdf
DOI : 10.1038/s41598-017-12788-4

Éditeur(s) : HAL CCSD Impact journals
Résumé : International audience
Interleukin (IL)-33 has been recently reported to be strongly pro-fibrogenic in various models of liver disease. Our aim was to study the role of endogenous IL-33 in a diet-induced model of steatohepatitis. IL-33 deficient mice and wild type (WT) littermates received a high-fat diet (HFD), or a standard diet for 12 weeks. The HFD-induced steatohepatitis was associated with an upregulation of IL-33 transcripts and protein. An insulin tolerance test revealed lower systemic insulin sensitivity in IL33-/-HFD mice than in WT-HFD mice. Nevertheless, IL-33 deficiency did not affect the severity of liver inflammation by histological and transcriptomic analyses, nor the quantity of liver fibrosis. Livers from HFD mice had more myeloid populations, markedly fewer NKT cells and higher proportion of ST2+ Treg cells and ST2+ type 2 innate lymphoid cells (ILC2), all unaffected by IL-33 deficiency. In conclusion, deficiency of endogenous IL-33 does not affect the evolution of experimental diet-induced steatohepatitis towards liver fibrosis.
ISSN: 1949-2553

hal-01578584
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578584
DOI : 10.18632/oncotarget.18335
PUBMED : 28611297

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BACKGROUND: Cancer/Testis (CT) genes are expressed in male gonads, repressed in most healthy somatic tissues and de-repressed in various somatic malignancies including prostate cancers (PCa). Because of their specific expression signature and their associations with tumor aggressiveness and poor outcomes, CT genes are considered to be useful biomarkers and they are also targets for the development of new anti-cancer immunotherapies. The aim of this study was to identify novel CT genes associated with hormone-sensitive prostate cancer (HSPC), and castration-resistant prostate cancer (CRPC). METHODS: To identify novel CT genes we screened genes for which transcripts were detected by RNA profiling specifically in normal testis and in either HSPC or CRPC as compared to normal prostate and 44 other healthy tissues using GeneChips. The expression and clinicopathological significance of a promising candidate-NR6A1-was examined in HSPC, CRPC, and metastatic site samples using tissue microarrays. RESULTS: We report the identification of 98 genes detected in CRPC, HSPC and testicular samples but not in the normal controls. Among them, cellular levels of NR6A1 were found to be higher in HSPC compared to normal prostate and further increased in metastatic lesions and CRPC. Furthermore, increased NR6A1 immunoreactivity was significantly associated with a high Gleason score, advanced pT stage and cancer cell proliferation. CONCLUSIONS: Our results show that cellular levels of NR6A1 are correlated with disease progression in PCa. We suggest that this essential orphan nuclear receptor is a potential therapeutic target as well as a biomarker of PCa aggressiveness. Prostate © 2013 Wiley Periodicals, Inc.
ISSN: 0270-4137

inserm-00821963
http://www.hal.inserm.fr/inserm-00821963
DOI : 10.1002/pros.22659
PUBMED : 23532770

Éditeur(s) : HAL CCSD American Society for Investigative Pathology
Résumé : International audience
Recent studies suggest that psoriasis may be more severe in patients with nonalcoholic fatty liver disease, particularly in those with the inflammatory stage of steatohepatitis [nonalcoholic steatohepatitis (NASH)]. Herein, we investigated the impact of diet-induced steatohepatitis on the severity of imiquimod-induced psoriasiform dermatitis. Mice fed with a high-fat diet developed steatohepatitis reminiscent of human NASH with ballooning hepatocytes and significant liver fibrosis. Mice with steatohepatitis also displayed moderate cutaneous inflammation characterized by erythema, dermalinfiltrates of CD45(+) leukocytes, and a local production of IL-17A. Moreover, steatohepatitis was associated with an epidermal activation of caspase-1 and cutaneous overexpression of IL-1 beta. Imiquimod-induced psoriasiform dermatitis was exacerbated in mice with steatohepatitis as compared to animals fed with a standard diet. Scale formation and acanthosis were aggravated, in correlation with increased IL-17A and IL-22 expression in inflamed skins. Finally, intradermal injection of IL-17A in standard diet-fed mice recapitulated the cutaneous pathology of mice with steatohepatitis. The results show that high-fat diet induced steatohepatitis aggravates the inflammation in psoriasiform dermatitis, via the cutaneous production of IL-17A. In agreement with clinical data, this description of a novel extrahepatic manifestation of NASH should sensitize dermatologists to the screening and the management of fatty liver in psoriatic patients.
ISSN: 0002-9440

hal-01390977
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390977
DOI : 10.1016/j.ajpath.2016.05.012
PUBMED : 27423696

Éditeur(s) : HAL CCSD
Résumé : International audience
This paper shows the information criteria (IC) performances in feature selection framework. Feature selection aims to select a representative subset among a wide set of features. We apply this approach to classify an hand segmented image. The performance is tested using various feature selection schemes (SFS, SBS, SFFS and SBFS) to select the candidate subsets. The accuracy of the approach is based on a good quality of the joint probability density approximation of the combined features. They are obtained using histogram optimized thanks to the adaptive arithmetic coding principles. Our approach is tested on different reference data. The subsets quality is evaluated using correct classification rate computed on multiple classifiers. Results show stability and convergence properties of this tool and its ability to select representative subsets (in the sense that the subset of feature is a good characterization of the classes in which the data belong). Information Criteria could be used for feature selection as a good alternative to other criteria.
CISP Proceedings
Shangay, China

hal-00634749
https://hal.archives-ouvertes.fr/hal-00634749

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
Loin d’apparaître comme de simples interfaces, les littoraux de la Caraïbe sont constituésd’enclaves fonctionnelles qui se juxtaposent donnant une mosaïque créole polyéthnique(mosaïque raciale), aux fractures sociales et spatiales marquées (mosaïque sociale et spatiale).Dans ces îles paysannes qui traditionnellement tournent le dos à la mer, la plage a longtempsété perçue par les populations littorales et les pêcheurs comme une continuité de l’île de laplantation pour y habiter et y pêcher. Une marge ouverte à tous dont la population rurale seméfiait pour ne l’aborder que quelques heures dans l’année à Pâques ou à la Pentecôte.2 Tout au long du XX siècle, une véritable subversion du regard s’opère par les classesdominantes, bourgeoises et touristes qui investissent les plages, souvent celles qui n’étaientguère fréquentées. Quitter la plage peu à peu investie par les touristes pour les fonds blancsou la Baignoire de Joséphine constitue une nouvelle marque, une volonté de maintenir unehiérarchie sociale par la distance.3 Depuis quelques années, les plages deviennent des lieux d’hybridation entre les populationslocales et les touristes. Avec la tertiairisation des sociétés, les populations antillaises desclasses moyennes et défavorisées découvrent les plages qui occupent une place importantedans la culture (publicité, télé…) des jeunes générations. Les plages sont investies etdeviennent peu à peu des espaces conviviaux.4 La ségrégation sociospatiale demeure cependant dans les pratiques, les temps et même lesespaces occupés. Si certains îlets et fonds blancs, comme les plages s’ouvrent au plus grandnombre, la piscine privée, le yacht, l’îlet privé, l’enclave protégée permettent toujours deconserver distance et discrétion. De même la capacité financière nécessaire à la pratique decertains sports nautiques permet cette démarcation. Ainsi, touristes, Métropolitains et Antillaisdes classes moyennes ou appartenant à la bourgeoisie, se côtoient et se croisent mais nepratiquent pas forcément la même plage.
ISSN: 1779-0980

hal-01202979
https://hal.archives-ouvertes.fr/hal-01202979
https://hal.archives-ouvertes.fr/hal-01202979/document
https://hal.archives-ouvertes.fr/hal-01202979/file/etudescaribeennes-693-4-la-plage-reflet-des-fractures-sociales-et-ethniques-aux-antilles.pdf
DOI : 10.4000/etudescaribeennes.693

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
La Guadeloupe (422 496 habitants) et la Martinique (381 427 habitants) appartiennent aux îles les plus peuplées et les plus riches des Petites Antilles. Les formes d’utilisation du littoral et des récifs sont variées (pêche, loisirs, tourisme) et les formes d’agression du milieu nombreuses et diverses (pollution, pêche, surfréquentation). Le haut niveau de développement induit davantage de pollution et une exploitation des eaux littorales importante. Le statut de DOM explique la multiplicité des moyens de protection et les réseaux d’acteurs. Les pouvoirs politiques agissent au niveau local (commune, département et région, national et européen) permettant de disposer de davantage de moyens mais entraînant souvent une certaine inertie et parfois des actions contradictoires.
ISSN: 1779-0980

hal-01174346
https://hal.archives-ouvertes.fr/hal-01174346

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Since the Shea, J.B. and Morgan (1979) study, investigators have repeatedly shown that the learning of a set of movement patterns (as evaluated in a retention test) is enhanced when acquisition occurred under a random rather than a blocked schedule of practice. Supposedly, this is the case because a random schedule of practice necessitates more elaborate cognitive activities than a blocked schedule before each acquisition trial can be initiated. Our main objective was to determine whether the advantage for learning found for random practice increases as a function of the number of acquisition trials. During acquisition, the results indicated a general tendency for smaller movement reproduction errors under a blocked rather than a random schedule of practice. However, this effect disappeared with larger amount of acquisition trials. In retention, larger errors were observed when acquisition occurred under a blocked rather than a random schedule of practice. Finally, the disadvantage for learning observed for the blocked schedule of practice disappeared under a block-repeated condition in which each movement pattern was first practiced under a blocked schedule which was then repeated a second time. The results are discussed in terms of the so-called contextual interference effect and indicates some of its limitations.
ISSN: 0001-6918

hal-01662846
https://hal.archives-ouvertes.fr/hal-01662846
DOI : 10.1080/00222895.1994.9941657
PUBMED : 8165923

Éditeur(s) : HAL CCSD
Résumé : International audience
Advances in Mathematical Sciences and Applications

hal-00515765
https://hal.archives-ouvertes.fr/hal-00515765

Éditeur(s) : HAL CCSD
Résumé : International audience
Xth European Workshop Imagery Conference
St Andrews, United Kingdom

hal-01635689
https://hal.archives-ouvertes.fr/hal-01635689

Éditeur(s) : HAL CCSD
Résumé : National audience
Objective of the study An estimation of burden of serious fungal diseases in France is essential data to inform public health priorities on the importance of resources and research needed on these infections. In France, precise data are available for invasive fungal diseases but estimates for several other diseases such as chronic and immunoallergic diseases are by contrast less known. Materials and methods A systematic literature search was conducted using the Web of Science Platform. Published epidemiology papers reporting fungal infection rates from France were identified. Where no data existed, we used specific populations at risk and fungal infection frequencies in those populations to estimate national incidence or prevalence, depending on the condition. Results The model predicts high prevalences of severe asthma with fungal sensitization episodes (189 cases/100,000 adults per year), of allergic bronchopulmonary aspergillosis (145/100,000) and of chronic pulmonary aspergillosis (5.24/100,000). Besides, estimated incidence for invasive aspergillosis is 1.8/100,000 annually based on classical high risk factors. Estimates for invasive mucormycosis, pneumocystosis and cryptococcosis are 0.12/100,000, 1/100,000 and 0.2/100,000, respectively. Regarding invasive candidiasis, more than 10,000 cases per year are estimated, and a much higher number of recurrent vaginal candidiasis is probable but must be confirmed. Finally, this survey was an opportunity to report a first picture of the frequency of tinea capitis in France. Conclusion Using local and literature data of the incidence or prevalence of fungal infections, approximately 1,000,000 (1.47%) people in France are estimated to suffer from serious fungal infections each year. © 2016 Elsevier Masson SAS
Journal de Mycologie Medicale

hal-01467554
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467554
DOI : 10.1016/j.mycmed.2016.11.001
PUBMED : 27887809

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0012-8252

hal-01671832
https://hal-univ-rochelle.archives-ouvertes.fr/hal-01671832
DOI : 10.1016/j.earscirev.2016.12.005

Éditeur(s) : HAL CCSD
Résumé : International audience
In vitro susceptibility of 933 Candida isolates, from 16 French hospitals, to micafungin was determined using the Etest in each center. All isolates were then sent to a single center for determination of MICs by the EUCAST reference method. Overall essential agreement between the two tests was 98.5% at ±2 log2 dilutions and 90.2% at ±1 log2 dilutions. Categorical agreement was 98.2%. The Etest is a valuable alternative to EUCAST for the routine determination of micafungin MICs in medical mycology laboratories. Copyright © 2016, American Society for Microbiology. All Rights Reserved.
Antimicrobial Agents and Chemotherapy

hal-01367142
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367142
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367142/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367142/file/Multicenter%20comparison%20of%20the%20Etest.pdf
DOI : 10.1128/AAC.00630-16

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
For a few years, Caribean population have discovered and have been using their seashores. However, because of the developpement of international tourism, the building of trading ports and the implementation of free trading zones, seashores are discontinuous access is often denied to local populations.
Les enclaves, qu’elles soient touristiques, industrielles, commerciales ou environnementales semblent être l’aboutissement de politiques de gestion qui ont mené à la marchandisation des littoraux de la Caraïbe. Elles apparaissent au moment où les insulaires occupent et s’approprient ces rivages. Les enclaves constituent des discontinuités aux synapses étroitement fermées vers l’île et au contraire ouvertes sur l’économie globalisée
ISSN: 1779-0980

hal-01174357
https://hal.archives-ouvertes.fr/hal-01174357
https://hal.archives-ouvertes.fr/hal-01174357/document
https://hal.archives-ouvertes.fr/hal-01174357/file/etudescaribeennes-543-3-territorialisation-et-enclaves-littorales-dans-les-iles-de-la-caraibe.pdf
DOI : 10.4000/etudescaribeennes.543

Éditeur(s) : HAL CCSD IOS Press
Résumé : International audience
Asymptotic Analysis

hal-00515750
https://hal.archives-ouvertes.fr/hal-00515750

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0893-9659

hal-00515780
https://hal.archives-ouvertes.fr/hal-00515780

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Holocene Lake Mega-Chad (LMC) was the largest late Quaternary water-body in Africa. The development of this giant paleo-lake is related to a northward shift of the isohyetes interpreted as evidence for an enhanced Monsoon (African Humid Period). Numerous preserved coastal features have been described all around the LMC shore. Such features reveal the main paleo-hydrodynamical tendencies. In the context of a closed water-body like LMC, hydrodynamics are forced mainly by winds. We use a three-dimensional numerical model (SYMPHONIE) to simulate the mean hydrodynamics in LMC under both Harmattan-like (northeasterly trade winds) and Monsoon-like (southwesterly winds) forcings. The northern part of LMC displays coastal features, such as sand spits, that are consistent with the simulations forced by Harmattan-like winds. Geomorphic features related to Monsoon-driven hydrodynamics are not clearly expressed. They could have developed during the early stage of LMC but subsequently reworked. At the time of sand-spit building, Harmattan-like driven hydrodynamics prevailed and related coastal features were preferentially preserved in the sedimentary record.
ISSN: 0033-5894

hal-00475633
https://hal.archives-ouvertes.fr/hal-00475633
DOI : 10.1016/j.yqres.2009.10.010

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
o abstract
ISSN: 1043-4666

hal-01485264
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01485264

Éditeur(s) : HAL CCSD
Résumé : Un dispositif expérimental a été élaboré pour effectuer l'étude systématique d'un écoulement d'air en convection naturelle dans un canal plan ouvert. Les conditions aux limites imposent une densité de flux uniforme sur une paroi, la paroi en vis-à-vis est chauffée par rayonnement de la première. L'étude s'intéresse à l'influence du nombre de Rayleigh et du rapport d'allongement du canal sur l'apparition d'une alimentation du thermosiphon par la section de sortie.Cet écoulement inverse est visualisé par tomographie laser et quantifié par des profils de vitesse mesurés par vélocimétrie laser.
Actes de la SFT 2008
TOULOUSE, France

hal-00292639
https://hal.archives-ouvertes.fr/hal-00292639