Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Glioblastoma (GB) is the most frequent and aggressive type of primary brain tumor. Recurrences are mostly located at the margin of the resection cavity in the peritumoral brain zone (PBZ). Although it is widely believed that infiltrative tumor cells in this zone are responsible for GB recurrence, few studies have examined this zone. In this study, we analyzed PBZ left after surgery with a variety of techniques including radiology, histopathology, flow cytometry, genomic, transcriptomic, proteomic, and primary cell cultures. The resulting PBZ profiles were compared with those of the GB tumor zone and normal brain samples to identify characteristics specific to the PBZ. We found that tumor cell infiltration detected by standard histological analysis was present in almost one third of PBZ taken from an area that was considered normal both on standard MRI and by the neurosurgeon under an operating microscope. The panel of techniques used in this study show that the PBZ, similar to the tumor zone itself, is characterized by substantial inter-patient heterogeneity, which makes it difficult to identify representative markers. Nevertheless, we identified specific alterations in the PBZ such as the presence of selected tumor clones and stromal cells with tumorigenic and angiogenic properties. The study of GB-PBZ is a growing field of interest and this region needs to be characterized further. This will facilitate the development of new, targeted therapies for patients with GB and the development of approaches to refine the per-operative evaluation of the PBZ to optimize the surgical resection of the tumor.
ISSN: 0167-594X

hal-01117083
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117083
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117083/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117083/file/Characterizing%20the%20Peritumoral%20Brain%20Zone_accepted.pdf
DOI : 10.1007/s11060-014-1695-8

Éditeur(s) : Copernicus Gesellschaft Mbh
Résumé : The Mediterranean Sea is one of the most oligotrophic marine areas on earth where nitrogen fixation has formally believed to play an important role in carbon and nitrogen fluxes. Although this view is under debate, the diazotrophs responsible for this activity have still not been investigated in the open sea. In this study, we characterised the surface distribution and species richness of unicellular and filamentous diazotrophs across the Mediterranean Sea by combining microscopic counts with size fractionated in situ hybridization (TSA-FISH), and 16S rDNA and nifH genes phylogenies. These genetic analyses were possible owing to the development of a new PCR protocol adapted to scarce microorganisms that can detect as few as 1 cell ml(-1) in cultures. Low concentrations of diazotrophic cyanobacteria were detected and this community was dominated at 99.9% by picoplankton hybridized to the Nitro821 probe, specific for unicellular diazotrophic cyanobacteria (UCYN). Among filamentous cyanobacteria only 0.02 filament ml(-1) of Richelia were detected in the eastern basin, while small (0.7-1.5 mu m) and large (2.5-3.2 mu m) Nitro821-targeted cells were recovered at all stations with a mean concentration of 3.5 cell ml(-1). The affiliation of the small Nitro821-targeted cells to UCYN-A was confirmed by 16S and nifH phylogenies in the western Mediterranean Sea. In the central and the eastern Mediterranean Sea no 16S rDNA and nifH sequence from UCYN was obtained as cells concentration were close to, or below PCR detection limit. Bradyrhizobium sequences dominated nifH clone libraries from picoplanktonic size fractions. A few sequences of gamma-proteobacteria were also detected in the central Mediterranean Sea. While low phosphate and iron concentrations could explain the absence of Trichodesmium sp., the factors that prevent the development of UCYN-B and C remain unknown. We also propose that the dominating picoplankters probably developed specific strategies, such as associations with protists or particles, and/or photosynthetic activity, to acquire carbon for sustaining diazotrophy.
Biogeosciences (1726-4170) (Copernicus Gesellschaft Mbh), 2011 , Vol. 8 , N. 3 , P. 827-840

Droits : Author(s) 2011. CC Attribution 3.0 License.
http://archimer.ifremer.fr/doc/00133/24392/22416.pdf
DOI:10.5194/bg-8-827-2011
http://archimer.ifremer.fr/doc/00133/24392/

Éditeur(s) : HAL CCSD
Résumé : International audience
This paper deals with data structures within GIS. Continuous phenomenons are usually represented by raster structures for simplicity reasons. With such structures spatial repartitions of the data is not easily interpretable. Moreover, in an overlapping clustering context these structures remove the links between the data and the algorithms. We propose a vector representation of such data based on non-regular multi-rings polygons. The structure requires multipart nested polygons and new set operations. We present the formalism based on belief theory and uncertainty reasoning. We also detail the implementation of the structures and the set operations. The structures and the set operations are illustrated in the context of forest classification having diffuse transitions.
IF&GIS
Shangai, China

hal-01514239
https://hal.archives-ouvertes.fr/hal-01514239

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Toxoplasma gondii is highly virulent in New World monkeys, but despite numerous outbreaks observed in captive populations there are few reports of molecular characterization of strains. In this article, we describe two outbreaks of toxoplasmosis that occurred in 2001 and 2006 in an outdoor captive breeding colony of squirrel monkeys (Saimiri sciureus) kept by the Institut Pasteur in French Guiana. A microsatellite DNA analysis of the biological samples collected in the 2001 and 2006 outbreaks showed that two different Toxoplasma strains were involved. The 2001 strain exhibited a type II genotype whereas the 2006 strain showed a combination of type I, type III and atypical alleles. Infection could be related to oocysts contaminating water or food, or to ingestion of rats by monkeys. In 2006, a second episode was observed 3 weeks after the first, and was believed to be related to direct contamination by tachyzoites of bronchopulmonary origin from dying monkeys of the first event. During both outbreaks, a total of 50 monkeys died and none recovered spontaneously, confirming the virulence of both type II and non-type II Toxoplasma strains in New World monkeys.
ISSN: 0304-4017

hal-00408048
https://hal.archives-ouvertes.fr/hal-00408048
DOI : 10.1016/j.vetpar.2009.04.004
PUBMED : 19423226

Éditeur(s) : Academia Brasileira de Ciencias
Résumé : During the Geobrésil cruise of the R. V. Jean Charcot (1973) several marine geophysical lines, including bathymetry, magnetism, continuous seismic as well as sonobuoy profiles have been run across a deep marginal plateau extending on the southeastern Brazilian margin and known as the Sao Paulo Plateau. These data indicate the presence of a thick sedimentary cover (more than 4s DTT) on the upper slope and up to 3s DTT thick on the lower slope and rise. The entire slope is highly disturbed by salt diapiric structures mostly apparent between the 2 000-3 000 bathymetriclines and comparable to the ones described in the western Mediterranean sea. The Sao Paulo scarp, bordering the deep marginal plateau to the South-West, is believed to be a discontinuous and "en échelon» structure probably related to numerous and closely spaced early fracture zones. The overal structures Of two areas - the Sao Paulo and the Angolan margin - are briefly cOmpared and Preliminary results of DSDP holes 356 and 364 suggest a similar sedimentary history, during mesozoic times, for both margins. [NOT CONTROLLED OCR]
Anais da Academia Brasileira de Ciencias (Academia Brasileira de Ciencias), 1976 , Vol. 48 , N. Supp. , P. 187-198

Droits : Academia Brasileira de Ciencias
http://archimer.ifremer.fr/doc/1976/publication-4990.pdf
http://archimer.ifremer.fr/doc/00000/4990/

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
PCR is the most widely applied technique for large scale screening of bacterial clones, mouse genotypes, virus genomes etc. A drawback of large PCR screening is that amplicon analysis is usually performed using gel electrophoresis, a step that is very labor intensive, tedious and chemical waste generating. Single genome amplification (SGA) is used to characterize the diversity and evolutionary dynamics of virus populations within infected hosts. SGA is based on the isolation of single template molecule using limiting dilution followed by nested PCR amplification and requires the analysis of hundreds of reactions per sample, making large scale SGA studies very challenging. Here we present a novel approach entitled Long Amplicon Melt Profiling (LAMP) based on the analysis of the melting profile of the PCR reactions using SYBR Green and/or EvaGreen fluorescent dyes. The LAMP method represents an attractive alternative to gel electrophoresis and enables the quick discrimination of positive reactions. We validate LAMP for SIV and HIV env-SGA, in 96- and 384-well plate formats. Because the melt profiling allows the screening of several thousands of PCR reactions in a cost-effective, rapid and robust way, we believe it will greatly facilitate any large scale PCR screening
ISSN: 1932-6203

hal-01163756
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163756
DOI : 10.1371/journal.pone.0128188
PUBMED : 26053379

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
We investigate upper mantle anisotropy beneath the Pyrenean range along three N-S profiles across the mountain belt. The results of a first profile that operated in 1993 in the central part of the belt have been presented elsewhere. We present the results of two other profiles that ran in 1995-1996 and 1996-1997 in the eastern and western part of the belt, respectively and propose an interpretation of the whole results. Teleseismic shear waves (SKS, SKKS, and PKS) are used to determine splitting parameters: the fast polarization direction φ and the delay time δt. Teleseismic shear wave splitting in the eastern Pyrenees displays homogeneous φ values trending N100°E and δt values in the range 1.1 to 1.5 s. A station located in the southern Massif Central, 100 km north of the range, is characterized by different splitting parameters (φ = N70°E, δt = 0.7 s). In the western part of the belt, anisotropy parameters are similar across the whole belt (φ = N110°E and δt = 1.3 to 1.5 s). Most of the measured delay times, including those obtained in the central part of the range, are above the global average of the SKS splitting (around 1 s). At the belt scale, φ is generally poorly correlated with recent estimations of the absolute plate motion, which predicts a fast direction ranging between N50°E and N80°E. Instead, the orientation of φ (N100°E) is parallel to the trend of the Pyrenean belt but also to Hercynian preexisting structures. This parallelism supports an anisotropy primarily related to frozen or active lithospheric structures. We show that a signature related to the Pyrenean orogeny is likely for the stations located in the internal domains of the belt. By contrast, the anisotropy measured at the stations located on the external parts of the belt could reflect a pre-Pyrenean (Hercynian) deformation. We suggest that a late Hercynian strike-slip deformation is responsible for this frozen upper mantle anisotropy and that the Pyrenean tectonic fabric developped parallel to this preexisting fabric. Finally, no particularly strong splitting is related to the North Pyrenean Fault, commonly believed to represent the plate boundary between Iberia and Eurasia.
ISSN: 2169-9313

hal-01388841
http://hal.univ-reunion.fr/hal-01388841
http://hal.univ-reunion.fr/hal-01388841/document
http://hal.univ-reunion.fr/hal-01388841/file/Barruol_Aniso_Pyr_JGR1998.pdf
DOI : 10.1029/98JB02790

Éditeur(s) : The American Asscoiation of Petroleum Geologists
Résumé : Several marine geophysical profiles off the southern part of the Niger delta reveal the presence of diapiric structures beneath the continental slope and rise. The origin of the diapiric material appears to be deep in the sedimentary section and is believed to be of Aptian-Albian age. If this hypothesis is correct, the presence of evaporite basins, known between angola and Gabon, can be extended as far north as the Niger delta. [NOT CONTROLLED OCR]
The American Asscoiation of Petroleum Geologists Bulletin (The American Asscoiation of Petroleum Geologists), 1973-09 , Vol. 57 , N. 9 , P. 1672-1678

Droits : The American Asscoiation of Petroleum Geologists
http://archimer.ifremer.fr/doc/1973/publication-5119.pdf
http://archimer.ifremer.fr/doc/00000/5119/

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : El turismo náutico se concibe como un segmento estratégico para el desarrollo turístico de España y sus destinos costeros. En Canarias existe una apuesta pública por la especialización del Archipiélago y su reposicionamiento como destino líder europeo de escala en el Atlántico, por las múltiples cualidades naturales que posee la región para el deporte náutico, y su posición geográfica estratégica en el cruce desde Europa hacia el Caribe. Así, se viene planteando una renovación y desarrollo del sector de la náutica de recreo y el turismo de yates, con estrategias enfocadas a la diversificación y el crecimiento. Los altos costes sociales y medioambientales asociados a este tipo de desarrollo justifican la necesidad de una mayor atención académica, que permita comprender las particularidades y complejidades de la actividad y este mercado turístico. En la misma medida en que esta actividad es vista como un factor de riesgo para el medioambiente, la comunidad local y la franja litoral, también son crecientes las preocupaciones y sensibilidad por parte de los turistas hacia estos fenómenos. Dada la carencia de investigaciones en el área, este estudio se propone identificar los determinantes de la satisfacción de los navegantes europeos con los puertos de escala de Canarias. Como resultado de encuestar a 185 navegantes europeos durante su escala en seis puertos deportivos del archipiélago en 2014 y 2015, y la validación de un sistema de ecuaciones estructurales, se ha podido demostrar, entre otros aspectos, que existe una predilección en el mercado de navegantes europeos por presenciar esfuerzos y políticas de gestión ambiental sostenible en las marinas, siendo éste un factor determinante de su satisfacción. Los hallazgos permiten elaborar una serie de recomendaciones a gestores y operadores turísticos del sector, en aras de contribuir al diseño de estrategias que garanticen un desarrollo más sostenible y razonable de la actividad, basados en el efecto positivo que producen estas estrategias en la demanda, y el potencial valor de diferenciación turística que otorga, en el entorno competitivo del sector.
The nautical activiity has great potential for the socio-economic development of tourism. In Spain, the sector is a priority concern, especially for the Canary Islands, which show a clear commitment to specialise and reposition the destination as a top quality nautical destination on a European level. These aspects, together with the prior experience and tradition these islands have as a stopover destination for vessels in the Atlantic, when crossing Europe towards the Caribbean, represent strengths that have not yet been taken advantage of in the archipelago’s attempt to move away from its image as a traditional sun and beach destination. The Governmental Authorities in the Canary Islands have clear strategies in place to promote the yachting tourism growth. However, renewing the sector is believed to be a difficult process because of the large number of factors that interact within the same. This is a phenomenon of sufficient social and environmental significance to justify academic attention. This research analyses therefore the determinants of the European yachtsmen´s satisfaction with the ports of call of the Canary Islands. Data results of questioning 185 European yachtsmen crossing the Atlantic during 2014 and 2015 reveal that, among other aspects, proper environmental management of marinas leads to an increasing yachtsmen´s satisfaction. The findings provide the opportunity for developing recommendations for tourism managers and practitioners, in the attempt to contribute to a more sustainable and reasoned development and growth in the sector. Based on the current preferences of the European market of yachtsmen, it is possible to assure that environmental and social responsibility policies are a key differentiation factor for the competitiveness of the sector.
Canaries

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.10584
http://journals.openedition.org/etudescaribeennes/10584

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We develop a block model for the Aegean and surrounding areas, constrained by Global Positioning System (GPS), in order to investigate the degree of coupling on the Hellenic subduction interface (i.e., the fraction of the motion across the plate boundary accommodated by elastic strain accumulation). We use previously published models, and seismicity to define the geometry of the interface separating the down-going Nubian slab from the overriding Aegean. This model provides a good fit to the GPS observations; for the ∼200,000 km2 Aegean block the wrms of the residual velocities is 1.4 mm/yr for 80 GPS velocity estimates, approximately the 95% level of the GPS velocity uncertainties. We investigate the degree of coupling on the seismically active plate interface, the Hellenic trench splay fault (believed to be the source of the 365 AD Great Crete Earthquake and Tsunami), and the Kephalonia transform fault by comparing the modeled GPS residual velocity field for a range of coupling values. The GPS observations are almost insensitive to coupling on the Kephalonia transform fault, because of the vertical dip of the fault that creates interseismic deformation only close to the fault where few GPS sites exist. The absence of resolvable shortening of the leading edge of the Aegean Plate precludes coupling of more than 0.2 (20% of the full Nubia-Aegean convergence rate) on the modeled plate interface. Because of the shallow dip of the plate interface and trench splay fault, and high rate of convergence, if these boundaries were fully coupled, high elastic strain rates would be expected to extend well into the overriding Aegean plate. Based on our preferred value for the degree of coupling (0.1), and assuming characteristic earthquake behavior, we estimate a recurrence time for great earthquakes with slip similar to that for the 365 Crete event of 5700-8300 yr, consistent with the absence of subsequent great earthquakes on this segment of the subduction zone.
ISSN: 0012-821X

hal-01053486
https://hal.archives-ouvertes.fr/hal-01053486
DOI : 10.1016/j.epsl.2013.10.018

Éditeur(s) : HAL CCSD American Public Health Association
Résumé : International audience
BACKGROUND: It is well established that high adherence to HIV-infected patients on highly active antiretroviral treatment (HAART) is a major determinant of virological and immunologic success. Furthermore, psychosocial research has identified a wide range of adherence factors including patients' subjective beliefs about the effectiveness of HAART. Current statistical approaches, mainly based on the separate identification either of factors associated with treatment effectiveness or of those associated with adherence, fail to properly explore the true relationship between adherence and treatment effectiveness. Adherence behavior may be influenced not only by perceived benefits-which are usually the focus of related studies-but also by objective treatment benefits reflected in biological outcomes. METHODS: Our objective was to assess the bidirectional relationship between adherence and response to treatment among patients enrolled in the ANRS CO8 APROCO-COPILOTE study. We compared a conventional statistical approach based on the separate estimations of an adherence and an effectiveness equation to an econometric approach using a 2-equation simultaneous system based on the same 2 equations. RESULTS: Our results highlight a reciprocal relationship between adherence and treatment effectiveness. After controlling for endogeneity, adherence was positively associated with treatment effectiveness. Furthermore, CD4 count gain after baseline was found to have a positive significant effect on adherence at each observation period. This immunologic parameter was not significant when the adherence equation was estimated separately. In the 2-equation model, the covariances between disturbances of both equations were found to be significant, thus confirming the statistical appropriacy of studying adherence and treatment effectiveness jointly. CONCLUSIONS: Our results, which suggest that positive biological results arising as a result of high adherence levels, in turn reinforce continued adherence and strengthen the argument that patients who do not experience rapid improvement in their immunologic and clinical statuses after HAART initiation should be prioritized when developing adherence support interventions. Furthermore, they invalidate the hypothesis that HAART leads to "false reassurance" among HIV-infected patients.
ISSN: 0025-7079

hal-00875196
https://hal.archives-ouvertes.fr/hal-00875196
DOI : 10.1097/MLR.0b013e3182422f61
PUBMED : 22362167

Éditeur(s) : HAL CCSD Society for Molecular Biology and Evolution
Résumé : International audience
Vibrio metoecus is the closest relative of Vibrio cholerae, the causative agent of the potent diarrheal disease cholera. Although the pathogenic potential of this new species is yet to be studied in depth, it has been co-isolated with V. cholerae in coastal waters and found in clinical specimens in the USA. We used these two organisms to investigate the genetic interaction between closely related species in their natural environment. The genomes of twenty V. cholerae and four V. metoecus strains isolated from a brackish coastal pond on the US east coast, as well as four clinical V. metoecus strains were sequenced and compared to reference strains. Whole genome comparison shows 86-87% average nucleotide identity (ANI) in their core genes between the two species. On the other hand, the chromosomal integron, which occupies approximately 3% of their genomes, shows higher conservation in ANI between species than any other region of their genomes. The ANI of 93-94% observed in this region is not significantly greater within than between species, meaning that it does not follow species boundaries. V. metoecus does not encode toxigenic V. cholerae major virulence factors, the cholera toxin and toxin co-regulated pilus. However, some of the pathogenicity islands found in pandemic V. cholerae were either present in the common ancestor it shares with V. metoecus, or acquired by clinical and environmental V. metoecus in partial fragments. The virulence factors of V. cholerae are therefore both more ancient and more widespread than previously believed. There is high interspecies recombination in the core genome, which has been detected in 24% of the single-copy core genes, including genes involved in pathogenicity. V. metoecus was six times more often the recipient of DNA from V. cholerae as it was the donor, indicating a strong bias in the direction of gene transfer in the environment.
ISSN: 1759-6653

Droits : http://creativecommons.org/licenses/by/
hal-01264332
http://hal.upmc.fr/hal-01264332
http://hal.upmc.fr/hal-01264332/document
http://hal.upmc.fr/hal-01264332/file/Genome%20Biol%20Evol-2015-Orata-gbe_evv193.pdf
DOI : 10.1093/gbe/evv193

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
127 patients from Tahiti who were suffering from elephantiasis were interviewed about their opinion of the origin of their disease. Ancestral beliefs are still widely held even after 25 years of antifilarial campaigns which have resulted in a drastic decrease in endemicity with almost no clinical incidence. It is disappointing that the responsibility of mosquitoes is denied by a majority of patients. The explanations are to be found in the unusual evolution of this disease and in the small importance attached to sanitary education.
ISSN: 0035-9203

hal-00715426
https://hal.univ-antilles.fr/hal-00715426
PUBMED : 45325

Éditeur(s) : ICCAT
Résumé : Because one of the most common problems in fisheries is the definition of management units, we propose in this paper a bibliometric review focusing on the differentiation of Albacore populations, Thunnus alalunga, among and within oceanic regions (Atlantic, Pacific and Indian Oceans, and Mediterranean Sea). This paper is the first step of a current work on a global review of Albacore tuna using an international aquatic database (ASFA). For the present purpose, 367 publications, mainly composed of articles (64%), but also conference papers, proceedings and reports (24%), and books (12%), were analyzed. We will see that the concept of the stock and its delimitation is controversial because of the divergence of results. Such a conclusion makes us believe in the urgent need of further studies targeting this currently overexploited species in most regions of the world, in order to improve management units currently used by regional organizations for fishery management.
Parce que l’un des problèmes les plus récurrents en halieutique est la définition même des unités de gestion, nous proposons dans ce papier un aperçu bibliographique traitant de la différentiation des populations de thon germon, Thunnus alalunga, au sein et entre les régions océaniques (l’océan Atlantique, Pacifique et Indien, et la mer Méditerranée). Ce papier est la première étape d’une revue en cours de rédaction sur le thon germon dans laquelle nous avons utilisé une base de données internationale aquatique (ASFA). Un total de 367 publications ont été traité comprenant principalement des articles scientifiques (64%), puis des conférences et rapports (24%), et des ouvrages (12%). Nous verrons que la notion de stock pour cette espèce et leur délimitation sont ambigües du fait des résultats divergents des études et de leur nature. Le principal constat est le besoin immédiat de travaux supplémentaires sur cette espèce considérée surexploitée dans la plupart des régions du monde et qui permettrait d’améliorer les limites des unités de stock actuellement utilisées par les organisations régionales des pêches.
Dado que uno de los problemas más comunes en las pesquerías es la definición de unidades de ordenación en este documento se propone una revisión bibliométrica centrada en la diferenciación de las poblaciones de atún blanco (Thunnus alalunga) entre y dentro de las regiones oceánicas (océanos Atlántico. Pacífico e Índico y mar Mediterráneo).).Este documento es el primer paso de una revisión global del atún blanco realizada mediante el uso de la base de datos acuática internacional (ASFA). En el documento se analizaron 367 publicaciones, sobre todo compuestas de artículos científicos (64%), pero también incluía la revisión de documentos, actas e informes de conferencias (24%) y libros (12%). Se puede observar que debido a las divergencias en los resultados, el concepto de stock y su delimitación sigue siendo un tema controvertido. Dichas conclusiones nos llevan a creer en la urgente necesidad de realizar estudios adicionales centrados en esta especie actualmente sobreexplotada en la mayoría de las regiones del mundo, con el fin de mejorar las unidades de ordenación utilizadas actualmente por las organizaciones regionales para fines de ordenación de pesquerías.
ICCAT Recueil de Documents Scientifiques (1021-5212) (ICCAT), 2013-07 , Vol. 70 , N. 3 , P. 1340-1354

Droits : 2013 ICCAT
http://archimer.ifremer.fr/doc/00149/25990/24085.pdf
http://archimer.ifremer.fr/doc/00149/25990/

Éditeur(s) : HAL CCSD Wiley
Résumé : 13 pages, 4 figures, to be published on J. Am. Cer. Soc
International audience
Since crack propagation in oxide materials at low crack velocities is partly determined by chemical corrosion, proper knowledge of the crack tip chemistry is crucial for understanding fracture in these materials. Such knowledge can be obtained only from in situ studies because the processes that occur in the highly confined environment of the crack tip are very different from those that take place at free surfaces, or that can be traced post mortem. We report the occurrence of hydrous liquid condensate between the two fracture surfaces in the vicinity of the tip of tensile cracks in silica. Observations are performed in real-time by means of atomic force microscopy (AFM) at continuously controlled crack velocities in the regime of stress corrosion. Condensate formation and changes in extent and shape are demonstrated for a wide range of macroscopic humidity at different crack speeds. Its liquid character is confirmed by the study of AFM phase-contrast data. It is believed that this evidence of a nanoscale liquid hydrous phase at the crack tip will enable novel insights in the chemistry of failure of oxide materials.
ISSN: 0002-7820

hal-00424984
https://hal.archives-ouvertes.fr/hal-00424984
ARXIV : cond-mat/0509209
DOI : 10.1111/j.1551-2916.2005.00765.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The extent of the global human footprint [ 1 ] limits our understanding of what is natural in the marine environment. Remote, near-pristine areas provide some baseline expectations for biomass [ 2, 3 ] and suggest that predators dominate, producing an inverted biomass pyramid. The southern pass of Fakarava atoll—a biosphere reserve in French Polynesia—hosts an average of 600 reef sharks, two to three times the biomass per hectare documented for any other reef shark aggregations [ 4 ]. This huge biomass of predators makes the trophic pyramid inverted. Bioenergetics models indicate that the sharks require ∼90 tons of fish per year, whereas the total fish production in the pass is ∼17 tons per year. Energetic theory shows that such trophic structure is maintained through subsidies [ 5–9 ], and empirical evidence suggests that sharks must engage in wide-ranging foraging excursions to meet energy needs [ 9, 10 ]. We used underwater surveys and acoustic telemetry to assess shark residency in the pass and feeding behavior and used bioenergetics models to understand energy flow. Contrary to previous findings, our results highlight that sharks may overcome low local energy availability by feeding on fish spawning aggregations, which concentrate energy from other local trophic pyramids. Fish spawning aggregations are known to be targeted by sharks, but they were previously believed to play a minor role representing occasional opportunistic supplements. This research demonstrates that fish spawning aggregations can play a significant role in the maintenance of local inverted pyramids in pristine marine areas. Conservation of fish spawning aggregations can help conserve shark populations, especially if combined with shark fishing bans.
ISSN: 0960-9822

hal-01359391
https://hal-univ-perp.archives-ouvertes.fr/hal-01359391
DOI : 10.1016/j.cub.2016.05.058

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
We read with interest the report by Desrosiers et al 1 on the association between maternal occupational exposure to organic solvents and some birth defects. Their case-control study examined occupational exposure to three classes of solvents (chlorinated, aromatic and Stoddard) and found one association--between neural tube defects (mainly spinal bifida) and maternal occupational exposure to chlorinated solvents, but no association with the other solvent classes or with oral clefts. In their discussion, the authors noted that previous findings on maternal occupational exposure to solvents and oral clefts were from European, mainly French, populations and they hypothesised that the inconsistency between their results and these previous studies might be due to different exposure profiles (eg, intensity and solvent formulation). Although this explanation is plausible, another explanation must be discussed: differences in the definition of exposure. Our research team conducted four of the five studies with positive results cited by Desrosiers et al.2-5 All four were population based and included, in addition to the solvent classes considered by Desrosiers et al, oxygenated solvents, for example, alcohols or glycol ethers. Exposure limited to only oxygenated solvents appears to be very frequent among working women: more than half of the solvent exposure group in Chevrier et al 4 were exposed only to that solvent class. Because previous studies found an increased risk of oral clefts to be associated principally with that specific exposure, failure to consider this association could explain the negative findings for oral clefts. Moreover, women who were exposed only to oxygenated solvents are included in the reference ('non-exposed') group here, which would result in underestimating associations with chlorinated and petroleum solvents. For both these reasons, we believe that the failure to consider oxygenated solvents led to underestimating the risk estimates for oral clefts.
ISSN: 1351-0711

hal-00875943
https://hal.archives-ouvertes.fr/hal-00875943
DOI : 10.1136/oemed-2012-100999
PUBMED : 22843438

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Access to health care is a global public problem. In French Guiana, there exists social inequalities which are specially marked amongst immigrants who make up a third of the population. Health care inequalities are prevalent. The objective of this study was to determine factors associated with why health care amongst the poor population of Cayenne was renounced.Study design The study was cross sectional. It focused on knowledge, attitudes, practices and beliefs of the population living in poor neighborhoods of the Cayenne area. Methods: Populations coming at the Red Cross mobile screening unit in poor urban areas of Cayenne were surveyed from July 2013 to June 2014. Structured questionnaires consisted of 93 questions. Written informed consent was requested at the beginning of the questionnaire. The predictors for renouncing medical care were determined using logistic regression models and tree analysis. Results: Twenty percent of persons had renounced care. Logistic regression showed that renouncement of health care was negatively associated with having no regular physician Adjusted Odds Ratio (AOR)=0.43 (95%CI=0.24-0.79) and positively associated with being embarrassed to ask certain questions AOR=6.81 (95%CI=3.98-11.65) and having been previously refused health care by a doctor AOR=3.08 (95%CI=1.43-6.65) . Tree analysis also showed that three of these variables were linked to renouncement, with feeling shy to ask certain questions as the first branching.Conclusion: Although most people felt it was easy to see a doctor, one in five had renounced health care. The variables identified by the models suggest vulnerable persons generally had previous negative encounters with the health system and felt unwanted or non eligible for healthcare. Health care mediation and welcoming staff may be simple solutions to the above problems which were underscored in our observations.
ISSN: 1472-6963

hal-01288656
https://hal.archives-ouvertes.fr/hal-01288656
https://hal.archives-ouvertes.fr/hal-01288656/document
https://hal.archives-ouvertes.fr/hal-01288656/file/Predictive%20factors%20for%20renouncing%20to%20care%20in%20FG.pdf
PUBMEDCENTRAL : PMC4731954

Éditeur(s) : Elsevier
Résumé : The fining upward trend commonly described on levees of turbidite systems can be either attributed to changes in the sediment supply (external forcing = allocyclic) or changes in the spillover processes related to the growth of the levee (internal forcing = autocyclic). However the real causes remain speculative and difficult to demonstrate. Knowledge of vertical change in flow velocity (or grain size) in turbidity currents, of the turbidity current's height, as well as the growth rate of a levee are theoretically sufficient to describe the evolution of the grain size of a leveed turbidite sequence deposited by spillover processes. A piston core (MD99-2344) retrieved on the right levee of the Petit-Rhone neofan, sampled an 8.50 m long turbidite sequence containing more than one hundred turbidite beds and showing a marked fining upward trend. With the help of two profiles describing respectively the vertical velocity [Stacey, M. and Bowen, A.J., 1988b. The vertical structure of turbidity currents and a necessary condition for self-maintenance, Journal of Geophysical Research, pp. 3543-3553.] and the vertical grain size [Migeon, S., 2000. Dunes geantes et levees sedimentaires en domaine marin profond: approche morphologique, sismique et sedimentologique. PhD Thesis, Universite Bordeaux 1, Talence, France, 288 pp.] of a turbidity current, and a simple graphical method, we test several hypotheses on the height of the turbidity current and on the grain size at the bottom of the turbidity current and we attempt to reproduce the vertical fining upward trend. Our results show that the fining upward trend of the turbidite facies can be explained by the aggradation of the turbidite levee and the gradual confinement of the turbidity currents in the channel. This is, therefore, an autocyclical phenomenon. However a high frequency variability of the grain size overprinted on the trend cannot be explained by internal forcing and is believed to be allocyclical, depending on changes to the sediment input. The vertical grain-size profile allows more realistic flow conditions to be determined and shows that the vertical velocity profile does not describe the ability of turbidity current to transport sediment. This simple graphical method allows a better understanding and quantification of the forcing on turbidite deposits and improves description of the characteristics of the turbidity currents from the grain size of the deposits.
Marine Geology (0025-3227) (Elsevier), 2006-12 , Vol. 234 , N. 1-4 , P. 191-213

Droits : 2006 Elsevier
http://archimer.ifremer.fr/doc/2006/publication-2311.pdf
DOI:10.1016/j.margeo.2006.09.019
http://archimer.ifremer.fr/doc/00000/2311/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
CK chondrites are highly oxidized meteorites containing abundant magnetite and trace amounts of Fe,Ni metal. Although the group is predominately composed of equilibrated meteorites (types 4-6), in recent years a significant number of new samples have been classified as being either CK3 or CK3-anomalous. These unequilibrated CKs often display a close affinity with members of the CV oxidized subgroup. CKs and CVs (oxidized subgroup) may therefore form a continuum and by implication could be derived from a single common parent body. To investigate the relationship between these two groups a detailed study of the oxygen isotope composition, opaque mineralogy and major and trace element geochemistry of a suite of CV and CK chondrites has been undertaken. The results of oxygen isotope analysis confirm the close affinity between CV and CK chondrites, while excluding the possibility of a linkage between the CO and CK groups. Magnetites in both CV and CK chondrites show significant compositional similarities, but high Ti contents are a diagnostic feature of the latter group. The results of major and trace element analysis demonstrate that both CV and CK chondrites show overlapping variation. Supporting evidence for a single common source for both groups comes from their similar cosmic-ray exposure age distributions. Recent reflectance spectral analysis is consistent with both the CVs and CKs being derived from Eos family asteroids, which are believed to have formed by the catastrophic disruption of a single large asteroid. Thus, a range of evidence appears to be consistent with CV and CK chondrites representing samples from a single thermally stratified parent body. In view of the close similarity between CV and CK chondrites some modification of the present classification scheme may be warranted, possibly involving integration of the two groups. One means of achieving this would be to reassigned CK chondrites to a subgroup of the oxidized CVs. It is recognized that a full evaluation of this proposal may require further study of the still poorly understood CK3 chondrites.
ISSN: 0016-7037

hal-00474633
https://hal.archives-ouvertes.fr/hal-00474633
DOI : 10.1016/j.gca.2009.11.029