Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Anti-Müllerian hormone (AMH) plays crucial roles in sexual differentiation and gonadal functions. However, the possible extragonadal effects of AMH on the hypothalamic-pituitary-gonadal axis remain unexplored. Here we demonstrate that a significant subset of GnRH neurons both in mice and humans express the AMH receptor, and that AMH potently activates the GnRH neuron firing in mice. Combining in vivo and in vitro experiments, we show that AMH increases GnRH-dependent LH pulsatility and secretion, supporting a central action of AMH on GnRH neurons. Increased LH pulsatility is an important pathophysiological feature in many cases of polycystic ovary syndrome (PCOS), the most common cause of female infertility, in which circulating AMH levels are also often elevated. However, the origin of this dysregulation remains unknown. Our findings raise the intriguing hypothesis that AMH-dependent regulation of GnRH release could be involved in the pathophysiology of fertility and could hold therapeutic potential for treating PCOS
ISSN: 2041-1723

hal-01259206
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259206
DOI : 10.1038/ncomms10055
PUBMED : 26753790

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
In this study we attempt to understand the water storage variations in a karst aquifer on the Larzac Plateau (South of France) using ground-based gravimetry. Surface to 60 m depth gravity measurements are performed three times a year since 2006 down a pothole, in complement to monthly absolute gravity (AG) measurements at three sites. The time variations of the surface to depth (STD) gravity differences are compared with the AG variations. Using a simple Bouguer plate model, we find that the STD gravity differences are very similar to the AG variations. The STD gravity differences are then used to determine apparent density values. These integrative density values are compared with measured grain densities from core samples to obtain an apparent porosity and saturation change representative of the investigated depth. The apparent porosity ranges from 4.8 to 7.3 per cent. We then discuss on the repartition of the apparent physical properties with respect to the epikarst and infiltration zone karst structures. We argue that AG and STD differences monitor epikarst water storage variations. Within this scope, we discuss the fact that seasonal scale water storage variation occurs predominantly in the epikarst.
ISSN: 0956-540X

hal-00413528
https://hal.archives-ouvertes.fr/hal-00413528
DOI : 10.1111/j.1365-246X.2009.04118.x

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
The aim of this study is to bring new information on water storage dynamics in karst systems from tiltmeter measurements. Newly developed long-base hydrostatic tiltmeters are installed at two sites on the Larzac plateau (France) in a karst aquifer of similar to 100 km(2) recharge area. Each site is located within a karst cave where two tilt directions are monitored. Significant reversible tilt deformation reaching amplitudes of 10(-6) to 10(-5) rad was observed at both sites following heavy precipitation. Elastic parameters were determined with an experiment in which a tiltmeter site was loaded by up to 25 t of weight at strategic locations at the ground surface. Mechanisms responsible for the observed tilt were then examined by means of finite element modeling. Deformation induced by water pressure changes in fractures is our preferred interpretation as the most plausible mechanism. Within this scope, we used the tiltmeter responses to extract time constants using lumped parameter modeling. Time constants are interpreted to be associated with the filling and emptying of fractures nearby the tiltmeters. These instruments therefore appear as useful tools to study the local dynamics of water infiltration in karst systems.
ISSN: 0043-1397

hal-00534461
https://hal.archives-ouvertes.fr/hal-00534461
DOI : 10.1029/2009WR008082

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Unravelling the detailed pressure–temperature–time-deformation (P–T–t-D) evolution of magmatic and metamorphic rocks provides essential insights into the timing and duration of partial melting and related plutonism during crustal flow and migmatitic dome formation. The Montagne Noire Axial Zone (MNAZ) is a migmatitic dome located within the Variscan orogen in the southern French Massif Central. The timing of the main thermal event that was responsible for intense partial melting is still highly debated. In this study we present new laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) age data on micaschists, migmatites and granites that clarify the P–T–t-D evolution of the MNAZ. Structurally controlled samples were collected in order to constrain the timing of metamorphism, migmatization and plutonism regarding the main structural pattern D1, D2 and D3. D1 and D2 correspond to nappe stacking and dextral transpression, respectively. D3 is related to vertical shortening and coaxial thinning with a preferential NE–SW- to E–W-directed stretching. LA-ICP-MS analyses on the syntectonic Anglès, Soulié and Martys granites yielded U–Th/Pb monazite ages of 305 ± 1.5, 306 ± 1.9 and 314 ± 2 Ma, respectively. Five migmatitic rocks sampled in the eastern and central Espinouse area yielded in situ ages ranging between 312 ± 2 and 301 ± 2 Ma. Along the dome envelope, two garnet–staurolite-bearing micaschists near Saint-Pons-de-Thomières village gave in situ U–Th–Pb ages of 312.1 ± 2.1 and 309.0 ± 3.1 Ma. A fine-grained gneiss with a D3 fabrics in the eastern dome envelope yield a 208Pb/232Th mean age at 305.7 ± 3.9 Ma. All ages obtained in this study for the micaschists, migmatites and granites range between 315 and 301 Ma. We interpret this time span as the record of the high thermal event responsible for intense crustal partial melting within the lower and middle crust. The onset of partial melting occurred at ca. 315 Ma that marked the beginning of transpressional deformation D2. Based on structural and petrological studies, our new U–Th–Pb results suggest that (1) partial melting may have started at ca. 315 Ma and lasted 15–10 Myr and (2) D2 et D3 developed between 315 and 300 Ma and were synchronous. D1 deformation ended at 315 Ma. The onset and duration of D1 related to nappe stacking and crustal thickening is still uncertain.
ISSN: 1437-3254

hal-01526942
https://hal.archives-ouvertes.fr/hal-01526942
DOI : 10.1007/s00531-016-1417-x

Éditeur(s) : HAL CCSD
Résumé : International audience
Although earthquakes and tsunamis are less frequent in the Dover Straitthan over active subduction zones, a plausible potential exists for intraplate earthquakes of magnitude Mw=6.9 generating a tsunami with damaging consequences. In April 1580, an earthquake shook the region violently and destructions were reported as far as London in the north andRouen in the south. Despite fair weather conditions, a series of abnormal sea waves was reported in several harbours (Calais, Boulogne and Dover) on the same day. A first step was to produce a range of numerical coseismic tsunami simulations and to compare them with historical witness accounts. Results raise the question of whether such earthquakes could also triggerchalk flow-generated tsunamis along cliff lines on both sides of the Strait. Gravity-driven collapses affect thechalk cliffs periodically, but local tsunami waves caused by very large mass movements could reach heights of several meters and, for example, strike Dover.
Proceedings of the 15th World Conference on Earthquake Engineering
Lisbonne, Portugal

halshs-01291496
https://halshs.archives-ouvertes.fr/halshs-01291496

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Fault friction is a parameter that is difficult to assess along fault zones since its determination depends on the knowledge of any factor controlling the state of stress around faults. In brittle homogeneous rocks, a limited number of these factors, such as the shape of the fault surface, the vicinity of fault tips or the remote stress ratio, are crucial to constrain for this determination. In this paper, we propose to analyse a field example in which all these properties are met and where the nature of the slipped structure suggest differences in static friction. We compare the orientations of branching fractures at strike-slip relay zones between en echelon stylolites and en echelon joints both reactivated in shear. The field data are compared with both photoelastic and 3-D numerical models that consider the remote stress conditions and the role of the geometry of the strike-slip segments. Based on field observations, these analyses quantitatively demonstrate the significant role of fault friction on the local stress field orientation and subsequent fracture formation. This work points out that estimations of fault friction based on analyses of fracture patterns or in situ stresses must be accompanied with a thorough investigation of the 3-D fault shape, its segmentation and the remote stress state.
ISSN: 0191-8141

hal-00560999
https://hal.archives-ouvertes.fr/hal-00560999
DOI : 10.1016/j.jsg.2010.01.008

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Spinel lherzolite xenoliths from Mont Briancon, French Massif Central, retain evidence for multiple episodes of melt depletion and melt/fluid infiltration (metasomatism). Evidence for primary melt depletion is still preserved in the co-variation of bulk-rock major elements (MgO 38.7-46.1 wt.%; CaO 0.9-3.6 wt.%), and many samples yield unradiogenic bulk-rock Os isotope ratios (Os-187/Os-188 = 0.11541-0.12626). However, many individual xenoliths contain interstitial glasses and melt inclusions that are not in equilibrium with the major primary minerals. Incompatible trace element mass balance calculations demonstrate that metasomatic components comprise a significant proportion of the bulk-rock budget for these elements in some rocks, ranging to as much as 25%, of Nd and 40% of Sr Critically, for Re-Os geochronology, melt/fluid infiltration is accompanied by the mobilisation of Sulfide. Consequently, bulk-rock isotope measurements, whether using lithophile (e.g. Rb-Sr, Sm-Nd) or siderophile (Re-Os) based isotope systems, may only yield a perturbed and/or homogenised average of these multiple events.;Osmium mass balance calculations demonstrate that bulk-rock Os in peridotite is dominated by contributions from two populations of sulfide grain: (i) interstitial, metasomatic Sulfide with low [Os] and radiogenic Os-187/Os-188, and (ii) primary sulfides with high [Os] and unradiogenic Os-187/Os-188, which have been preserved within host silicate grains and shielded from interaction with transient melts and fluid. The latter can account for >97% of bulk-rock Os and preserve geochronological information of the melt from which they originally precipitated as an immiscible liquid. The Re-depletion model ages of individual primary sulfide grains preserve evidence for melt depletion beneath the Massif Central from at least 1.8 Gyr ago despite the more recent metasomatic event(s). (C) 2009 Elsevier Ltd. All rights reserved.
ISSN: 0016-7037

hal-00454537
https://hal.archives-ouvertes.fr/hal-00454537
DOI : 10.1016/j.gca.2009.09.031

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
Previous estimates of the geodetic and geologic slip rates of the 1500 km long Altyn Tagh fault bordering the northern edge of the Tibetan plateau vary by a factor of five. Proposed reasons for these discrepancies include poor GPS geometry, interpretative errors in terrace morphology, and changes in fault slip rate over time. Here we present results from a new dense GPS array orthogonal to the fault at ~86.2°E that indicates a velocity of 9.0−3.2/+4.4 mm/yr, in close agreement with geomorphologic estimates at the same location. Our estimated geodetic slip rate is consistent with recent geological slip rates based on terrace offsets. The resulting mean combined geological and geodetic slip rate (9.0 ± 4.0 mm/yr) is remarkably uniform for the central ~800 km of the Altyn Tagh fault, significantly lower than early kinematic estimates and consistent with deformation elsewhere in Tibet and central Asia.
ISSN: 0094-8276

hal-00963568
https://hal.archives-ouvertes.fr/hal-00963568
DOI : 10.1002/2013GL057497

Éditeur(s) : HAL CCSD
Résumé : International audience
Advances in Natural and Technological Hazards Research

hal-01676621
https://hal.univ-antilles.fr/hal-01676621

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
P>The Strait of Hormuz area is a transition zone between the continental collision of the Zagros (west) and the subduction of an oceanic part of the Arabian Plate beneath the Makran wedge (east). Geology and recent GPS measurements indicate that about 15 mm yr-1 of relative motion in N10 degrees E direction is accommodated by two major fault systems: (1) the NNW-trending Minab-Zendan-Palami (MZP) fault system that connects the Main Zagros Thrust (MZT) to the inner Makran thrust system and the Frontal subduction thrust and (2) the N-trending Sabzevaran-Kahnuj-Jiroft (SKJ) fault system that bounds the Jazmurian depression to the west. We use dense GPS measurements along four transects across these fault systems in order to determine the strains spatial distribution. The northern GPS transect confirms the total fault slip rates for both fault systems estimated by the tectonic analyses (about 10 and 7.3 mm yr-1 in N10 degrees direction across the MZP and SKJ fault systems, respectively). For both fault systems, the elastic deformation spreads over shear zones that are several tens of kilometres wide. However, transects located close to latitude 27 degrees N reveal a much narrower shear zone (similar to 10 km) for the MZP fault system. Moreover, we confirm that most of the present-day strain is transferred towards the frontal subduction thrust rather than towards the inner Makran thrusts. In order to complement this new GPS velocity field with spatially dense measurements, we processed a set of ERS radar images by the radar interferometry (InSAR) technique. We used both a 'stacking' and a 'persistant-scatterers' approach to differentiate the ground deformation signal which spatial gradient is expected to be very low, from the atmospheric signal. Results from these interferograms appear to be relatively in agreement with the GPS-determined strain distribution. Nevertheless, they confirm the absence of any superficial creep behaviour since no sharp discontinuity on interferometric phase can be noted on any interferogram. Finally, we use a purely kinematic 'block model' inversion process to calculate slip rates and locking depths for each fault system from our GPS measurements. These models suggest that the relative quiescence over the last 200 yr has certainly produced a slip deficit as high as 2 m. So, we may wonder if the MZP fault system is not late in the interseismic phase of its earthquake cycle.
ISSN: 0956-540X

hal-00429386
https://hal.archives-ouvertes.fr/hal-00429386
DOI : 10.1111/j.1365-246X.2009.04321.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : TAG LITHO
In this study we attempt to understand the water storage variations in a karst aquifer on the Larzac Plateau (South of France) using absolute gravimetry. On this karst system, water input is exclusively rainfall and draining occurs at the Durzon perennial spring in a karstic valley. Our basis assumption is that water storage in the vadose zone (epikarst and infiltration zone) has a significant effect on surface gravity through Newtonian attraction. The karst aquifer is hence being monitored since January 2006 with monthly absolute gravity measurements at three sites. The gravity measurements are corrected for regional scale gravity using water storage models in order to obtain gravity variations related exclusively to the local water storage variations. The gravity variations exhibit an important seasonal component (10-15 mu gal corresponding to a variation of equivalent water stab thickness of similar to 24-36 cm). Water storage variation seen by gravimetry is not spatially uniform on the studied karst system, corroborating current geomorphologic observations and interpretations. Finally, we use a global mass balance consideration linking rainfall, evapotranspiration and spring discharge to provide a conceptual framework for the understanding of observed gravity variations.
ISSN: 0022-1694

hal-00411884
https://hal.archives-ouvertes.fr/hal-00411884
DOI : 10.1016/j.jhydrol.2008.06.020

Éditeur(s) : Paris : Imprimerie nationale
Extrait de : Notice sur la transportation à la Guyane française et à la Nouvelle-Calédonie
Résumé : Cartes, tableaux
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Ville de Bordeaux. Bibliothèque municipale
Permalien : http://www.manioc.org/patrimon/BBX19040
BBX19040

Éditeur(s) : Paris : Imprimerie nationale
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Communauté d'agglomération de La Rochelle. Médiathèque Michel-Crépeau
Permalien : http://www.manioc.org/patrimon/MMC16007-2
MMC16007-2

Éditeur(s) : Paris : Imprimerie nationale
Extrait de : Notice sur la transportation à la Guyane française et à la Nouvelle-Calédonie
Résumé : Cartes, tableaux
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Ville de Bordeaux. Bibliothèque municipale
Permalien : http://www.manioc.org/patrimon/BBX19041
BBX19041