Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
1. Our understanding of the contribution of interspecific interactions to functional diversity in nature lags behind our knowledge of spatial and temporal patterns. Although two-species mutualisms are found in all types of ecosystems, the study of their ecological influences on other community members has mostly been limited to third species, while their influence on entire communities remains largely unexplored. 2. We hypothesized that mutualistic interactions between two respective ant species and an epiphyte mediate the biological traits composition of entire invertebrate communities that use the same host plant, thereby affecting food webs and functional diversity at the community level. 3. Aechmea mertensii (Bromeliaceae) is both a phytotelm ('plant-held water') and an ant-garden epiphyte. We sampled 111 bromeliads (111 aquatic invertebrate communities) associated with either the ant Pachycondyla goeldii or Camponotus femoratus. The relationships between ants, bromeliads and invertebrate abundance data were examined using a redundancy analysis. Biological traits information for invertebrates was structured using a fuzzy-coding technique, and a co-inertia analysis between traits and abundance data was used to interpret functional differences in bromeliad ecosystems. 4. The vegetative traits of A. mertensii depended on seed dispersion by C. femoratus and P. goeldii along a gradient of local conditions. The ant partner selected sets of invertebrates with traits that were best adapted to the bromeliads' morphology, and so the composition of the biological traits of invertebrate phytotelm communities depends on the identity of the ant partner. Biological traits suggest a bottom-up control of community structure in C. fenaoratus-associated phytotelmata and a greater structuring role for predatory invertebrates in P. goeldii-associated plants. 5. This study presents new information showing that two-species mutualisms affect the functional diversity of a much wider range of organisms. Most biological systems form complex networks where nodes (e.g. species) are more or less closely linked to each other, either directly or indirectly, through intermediate nodes. Our observations provide community-level information about biological interactions and functional diversity, and perspectives for further observations intended to examine whether large-scale changes in interacting species/community structure over broad geographical and anthropogenic gradients affect ecosystem functions.
Functional Ecology

hal-01096909
https://hal-agroparistech.archives-ouvertes.fr/hal-01096909
DOI : 10.1111/j.1365-2435-2011.01863.x

Éditeur(s) : HAL CCSD Society of Economic Geologists
Résumé : International audience
The ~8-Moz Sadiola Hill gold deposit is located in the Kédougou-Kénieba inlier, a window of deformed ca. 2200 to 2050 Ma rocks that crop out in eastern Senegal and western Mali. The geology of the inlier differs from other Paleoproterozoic granite-greenstone belts and sedimentary basins by the abundance of carbonate rocks. The Sadiola Hill gold deposit occurs within 3 km of the Senegal-Mali shear zone, and country rocks in the region have undergone polycyclic deformation. The lithostratigraphy of the open pit consists of impure limestones overlain by younger sequences of detrital sedimentary rocks, which include arenite, wacke, and siltstone. The sedimentary rocks have been subjected to regional greenschist-facies metamorphism and have been intruded by multiple generations of synkinematic, calc-alkaline stocks and dikes. The bulk of the ore is hosted within a N-S- to NNW-trending, 10- to 50-m-wide, brittle-ductile dilational shear zone defined as the Sadiola shear zone. Gold lodes also occur along an array of steep NNE-trending shear zones. Geometric and kinematic analyses indicate that the ore-hosting structures were undergoing sinistral displacement at the time of mineralization, locally defined as the D3s NNW-SSE-shortening event. Hydrothermal alteration is polyphase and includes an early high-temperature calc-silicate phase (i.e., porphyroblastic growth of actinolite-tremolite) followed by a potassic phase (i.e., biotite-calcite-quartz ± K-feldspar-tourmaline-actinolite) that was synchronous with ore mineral deposition. Paragenetic studies reveal a multistage ore development that includes an As-rich sulfide stage, followed by an Au-Sb stage. The ore is associated with a metal enrichment suite of Au-As-Sb ± Cu-Fe-W-Mo-Ag-Bi-Zn-Pb-Te. The Sadiola Hill deposit shares a similar relative timing and structural setting to that of other world-class orogenic gold systems in the West African craton (e.g., Ashanti, Loulo), with gold deposition occurring during a period of transcurrent tectonics, after the cessation of region-wide compressional deformation. The high-temperature paragenesis at Sadiola Hill is atypical of gold mineralization in the craton and indicates that the late Eburnean tectono-magmatic activity between ca. 2080 and 2060 Ma played an important role in the dynamics of hydrothermal fluid circulation along the Senegal-Mali shear zone.
ISSN: 0361-0128

hal-01583358
https://hal.archives-ouvertes.fr/hal-01583358
DOI : 10.2113/econgeo.112.1.23

Éditeur(s) : HAL CCSD Oxford University Press (OUP): Policy P - Oxford Open Option A Oxford University Press (OUP)
Résumé : International audience
The Pyrenean mountain range is a slowly deforming belt with continuous and moderate seismic activity. To quantify its deformation field, we present the velocity field estimated from a GPS survey of the Pyrenees spanning 18 yr. The PotSis and ResPyr networks, including a total of 85 GPS sites, were installed and first measured in 1992 and 1995–1997, respectively, and remeasured in 2008 and 2010. We obtain a deformation field with velocities less than 1 mm yr−1 across the range. The estimated velocities for individual stations do not differ significantly from zero with 95 per cent confidence. Even so, we estimate a maximum extensional horizontal strain rate of 2.0 ± 1.7 nanostrain per year in a N–S direction in the western part of the range. We do not interpret the vertical displacements due to their large uncertainties. In order to compare the horizontal strain rates with the seismic activity, we analyse a set of 194 focal mechanisms using three methods: (i) the ‘r’ factor relating their P and T axes, (ii) the stress tensors obtained by fault slip inversion and (iii) the strain-rate tensors. Stress and strain-rate tensors are estimated for: (i) the whole data set, (ii) the eastern and western parts of the range separately, and (iii) eight zones, which are defined based on the seismicity and the tectonic patterns of the Pyrenees. Each of these analyses reveals a lateral variation of the deformation style from compression and extension in the east to extension and strike-slip in the west of the range. Although the horizontal components of the strain-rate tensors estimated from the seismic data are slightly smaller in magnitude than those computed from the GPS velocity field, they are consistent within the 2σ uncertainties. Furthermore, the orientations of their principal axes agree with the mapped active faults.
ISSN: 0956-540X

hal-01171752
https://hal.archives-ouvertes.fr/hal-01171752
DOI : 10.1093/gji/ggv052

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
Les risques hydrométéorologiques sont au coeur du programme de recherche HyMeX sur le cycle de l'eau en Méditerranée. HyMeX a pour ambition d'améliorer leur prévision, de mieux connaître leur variabilité à l'échelle pluriannuelle et de renseigner sur leur évolution, dans le contexte du changement climatique. À cette fin, deux campagnes de mesures dédiées à ces événements extrêmes (SOP1 : pluies intenses et crues rapides ; SOP2 : vents forts et formation d'eaux denses) sont organisées en Méditerranée nord-occidentale, entre septembre 2012 et mars 2013.
ISSN: 0026-1181

hal-00829760
https://hal.archives-ouvertes.fr/hal-00829760
DOI : 10.4267/2042/48793

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The current interpretation of the Messinian Salinity Crisis (MSC) involves the deposition of peripheral or marginal evaporites in onshore basins as well as the erosion of the margin and the deposition of thick evaporites in deep basins. The so-called intermediate basins are formed in domains between the onland outcrops and the deep basins. The Balearic Promontory is a bathymetric high located between the deep Algerian and Liguro-Provençal basins and the onland Spanish basin. The SIMBAD project aims to investigate the spatial variability of the MSC-related deposits and to assess the extent of post-MSC reactivation over the Balearic Promontory. We present here the first results of the SIMBAD high-resolution seismic survey (January 2013) which imaged for the first time a thin MSC-related unit widely distributed in small sub-basins over the Balearic Promontory.Borehole analyses have shown that this unit could be correlated with primary gypsum formations linked to the peripheral evaporites. Locally, in the Central Depression between Mallorca and Ibiza islands, a thicker MSC unit is observed whose lowermost transparent part could correspond to a salt layer. Geometrical relationships suggest that the MSC in the Central Depression could postdate the primary gypsum. The occurrence of a halite layer in the Central Depression, at depths of 1000 to 1500 m, favours the hypothesis that the evaporites precipitated passively in closed or partially closed perched sub-basins, possibly as a result of evaporative drawdown at different depths and possibly diachronously, at least with respect to the deep-basin evaporites.
ISSN: 0264-8172

hal-01364255
https://hal.archives-ouvertes.fr/hal-01364255
DOI : 10.1016/j.marpetgeo.2014.09.008

Éditeur(s) : HAL CCSD Elsevier
Résumé : DNA metabarcoding on soil samples is increasingly used for large-scale and multi-taxa biodiversity studies. However, DNA extraction may be a major bottleneck for such wide uses. It should be cost/time effective and allow dealing with large sample volumes so as to maximise the representativeness of both micro- and macro-organisms diversity. Here, we compared the performances of a fast and cheap extracellular DNA extraction protocol with a total DNA extraction method in retrieving bacterial, eukaryotic and plant diversity from tropical soil samples of ca. 10 g. The total DNA extraction protocol yielded more high-quality DNA. Yet, the extracellular DNA protocol provided similar diversity assessments although it presented some differences in clades relative abundance and undersampling biases. We argue that extracellular DNA is a good compromise between cost, labor, and accuracy for high throughput DNA metabarcoding studies of soil biodiversity.
ISSN: 0038-0717

hal-01532638
https://hal.archives-ouvertes.fr/hal-01532638
DOI : 10.1016/j.soilbio.2016.01.008
PRODINRA : 384522

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ISSN: 0884-8173

hal-00858729
https://hal.archives-ouvertes.fr/hal-00858729

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In French Guiana, Quassia amara L. (Simaroubaceae) leaf tea is a well-known widely used traditional antimalarial remedy. Impact of the vegetal sampling condition on in vivo and in vitro antimalarial activity was assessed. Traditional infusions were prepared with juvenile or mature leaves, both either fresh or dried. Results showed that growing stage and freshness of vegetal material exert a striking effect on antimalarial activity, both in vitro and in vivo. By far, leaf tea made from fresh juvenile (FJ) Quassia amara leaves was the most active. In vitro, active component (simalikalactone D) concentration correlates biological activities, although unexplained subtle variations were observed. In vivo, tea made with dried juvenile (DJ) leaves displays a peculiar behavior, meaning that some components may help simalikalactone D delivery or may be active in vivo only, therefore enhancing the expected curative effect of the traditional preparation.
ISSN: 0378-8741

hal-00384338
https://hal.archives-ouvertes.fr/hal-00384338
DOI : 10.1016/j.jep.2006.10.028

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
D'initiative française, le projet international HyMeX a pour objectif d'améliorer la compréhension du cycle de l'eau en Méditerranée, de sa variabilité, de l'échelle de l'événement météorologique aux échelles saisonnières et interannuelles, et de ses caractéristiques sur une décennie, dans un contexte de changement global. Le projet est motivé par le rôle déterminant des processus de mésoéchelle, couplés entre l'atmosphère, la mer et la terre, sur la variabilité du système climatique et sur le déclenchement d'événements hydrométéorologiques extrêmes (précipitations et inondations, vents forts et convection océanique, canicules et sécheresses). Le projet vise enfin à évaluer les conséquences de ces événements extrêmes sur la vulnérabilité sociale et économique de cette région et sa capacité d'adaptation.
ISSN: 0026-1181

hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758/document
https://hal.archives-ouvertes.fr/hal-00828758/file/meteo_2013_80_23%20%281%29.pdf
DOI : 10.4267/2042/48792

Éditeur(s) : HAL CCSD Société nationale de protection de la nature (France)
Résumé : International audience
Les plantes qui présentent des structures anatomiques permettant de retenir de l'eau en permanence sont assez répandues en milieu tropical. Si beaucoup sont maintenant cultivées pour être vendues en jardineries, faisant le bonheur des amateurs, elles forment en milieu naturel des écosystèmes aquatiques encore très peu étudiés et renferment une biodiversité que l'on est loin d'avoir recensée. En Amérique centrale et du Sud, les broméliacées-citerne, qui représentent les plus nombreuses et les plus diversifiées de ces " plantes-mares ", permettent à des organismes très variés d'accomplir leur cycle de vie
ISSN: 0011-0477

hal-00849049
https://hal.archives-ouvertes.fr/hal-00849049
https://hal.archives-ouvertes.fr/hal-00849049/document
https://hal.archives-ouvertes.fr/hal-00849049/file/Carrias2013_Des_plantes.pdf

Éditeur(s) : HAL CCSD Nordic Ecological Society
Résumé : Niche differentiation and ecological filtering are primary ecological processes that shape community assembly, but their relative importance remains poorly understood. Analyses of the distributions of functional traits can provide insight into the community structure generated by these processes. We predicted the trait distributions expected under the ecological processes of niche differentiation and environmental filtering, then tested these predictions with a dataset of 4672 trees located in nine 1-ha plots of tropical rain forest in French Guiana. Five traits related to leaf function (foliar N concentration, chlorophyll content, toughness, tissue density and specific leaf area), and three traits related to stem function (trunk sapwood density, branch sapwood density, and trunk bark thickness), as well as laminar surface area, were measured on every individual tree. There was far more evidence for environmental filtering than for niche differentiation in these forests. Furthermore, we contrasted results from species-mean and individual-level trait values. Analyses that took within-species trait variation into account were far more sensitive indicators of niche differentiation and ecological filtering. Species-mean analyses, by contrast, may underestimate the effects of ecological processes on community assembly. Environmental filtering appeared somewhat more intense on leaf traits than on stem traits, whereas niche differentiation affected neither strongly. By accounting for within-species trait variation, we were able to more properly consider the ecological interactions among individual trees and between individual trees and their environment. In so doing, our results suggest that the ecological processes of niche differentiation and environmental filtering may be more pervasive than previously believed.
ISSN: 0030-1299

hal-01032397
https://hal.archives-ouvertes.fr/hal-01032397
DOI : 10.1111/j.1600-0706.2010.19110.x

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Mutualisms, or interactions between species that lead to net fitness benefits for each species involved, are stable and ubiquitous in nature mostly due to "byproduct benefits" stemming from the intrinsic traits of one partner that generate an indirect and positive outcome for the other. Here we verify if myrmecotrophy (where plants obtain nutrients from the refuse of their associated ants) can explain the stability of the tripartite association between the myrmecophyte Hirtella physophora, the ant Allomerus decemarticulatus and an Ascomycota fungus. The plant shelters and provides the ants with extrafloral nectar. The ants protect the plant from herbivores and integrate the fungus into the construction of a trap that they use to capture prey; they also provide the fungus and their host plant with nutrients. During a 9-month field study, we over-provisioned experimental ant colonies with insects, enhancing colony fitness (i.e., more winged females were produced). The rate of partial castration of the host plant, previously demonstrated, was not influenced by the experiment. Experimental plants showed higher δ¹⁵N values (confirming myrmecotrophy), plus enhanced vegetative growth (e.g., more leaves produced increased the possibility of lodging ants in leaf pouches) and fitness (i.e., more fruits produced and more flowers that matured into fruit). This study highlights the importance of myrmecotrophy on host plant fitness and the stability of ant-myrmecophyte mutualisms.
PLoS ONE

hal-00913754
https://hal.archives-ouvertes.fr/hal-00913754
https://hal.archives-ouvertes.fr/hal-00913754/document
DOI : 10.1371/journal.pone.0059405
OATAO : 10202

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Within the framework of the international field campaign COPS (Convective and Orographically induced Precipitation Study), a large suite of state-of-the-art meteorological instrumentation was operated, partially combined for the first time. This includes networks of in situ and remote-sensing systems such as the Global Positioning System as well as a synergy of multi-wavelength passive and active remote-sensing instruments such as advanced radar and lidar systems. The COPS field phase was performed from 01 June to 31 August 2007 in a low-mountain area in southwestern Germany/eastern France covering the Vosges mountains, the Rhine valley and the Black Forest mountains. The collected dataset covers the entire evolution of convective precipitation events in complex terrain from their initiation, to their development and mature phase until their decay. Eighteen Intensive Observations Periods with 37 operation days and eight additional Special Observations Periods were performed, providing a comprehensive dataset covering different forcing conditions. In this article, an overview of the COPS scientific strategy, the field phase, and its first accomplishments is given. Highlights of the campaign are illustrated with several measurement examples. It is demonstrated that COPS research provides new insight into key processes leading to convection initiation and to the modification of precipitation by orography, in the improvement of quantitative precipitation forecasting by the assimilation of new observations, and in the performance of ensembles of convection-permitting models in complex terrain.
ISSN: 0035-9009

hal-00565513
https://hal.archives-ouvertes.fr/hal-00565513
DOI : 10.1002/qj.752

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Ethnopharmacological relevancePsidium acutangulum Mart. ex DC is a small tree used by the Wayana Amerindians from the Upper-Maroni in French Guiana for the treatment of malaria.Aim of the studyIn a previous study, we highlighted the in vitro antiplasmodial, antioxidant and anti-inflammatory potential of the traditional decoction of P. acutangulum aerial parts. Our goal was then to investigate on the origin of the biological activity of the traditional remedy, and eventually characterize active constituents.Materials and methodsLiquid-liquid extractions were performed on the decoction, and the antiplasmodial activity evaluated against chloroquine-resistant FcB1 ([3H]-hypoxanthine bioassay) and 7G8 (pLDH bioassay) P. falciparum strains, and on a chloroquine sensitive NF54 ([3H]-hypoxanthine bioassay) P. falciparum strain. The ethyl acetate fraction (D) was active and underwent bioguided fractionation. All the isolated compounds were tested on P. falciparum FcB1 strain. In vitro anti-inflammatory activity (IL-1β, IL-6, IL-8, TNFα) of the ethyl acetate fraction and of an anti-Plasmodium active compound, was concurrently assessed on LPS-stimulated human PBMC and NO secretion inhibition was measured on LPS stimulated RAW murine macrophages. Cytotoxicity of the fractions and pure compounds was measured on VERO cells, L6 mammalian cells, PBMCs, and RAW cells.ResultsFractionation of the ethyl acetate soluble fraction (IC50 ranging from 3.4 to <1 µg/mL depending on the parasite strain) led to the isolation of six pure compounds: catechin and five glycosylated quercetin derivatives. These compounds have never been isolated from this plant species. Two of these compounds (wayanin and guaijaverin) were found to be moderately active against P. falciparum FcB1 in vitro (IC50 5.5 and 6.9 µM respectively). We proposed the name wayanin during public meetings organized in June 2015 in the Upper-Maroni villages, in homage to the medicinal knowledge of the Wayana population. At 50 µg/mL, the ethyl acetate fraction (D) significantly inhibited IL-1β secretion (−46%) and NO production (−21%), as previously observed for the decoction. The effects of D and guiajaverin (4) on the secretion of other cytokines or NO production were not significant.ConclusionsThe confirmed antiplasmodial activity of the ethyl acetate soluble fraction of the decoction and of the isolated compounds support the previous results obtained on the P. acutangulum decoction. The antiplasmodial activity might be due to a mixture of moderately active non-toxic flavonoids. The anti-inflammatory activities were less marked for ethyl acetate fraction (D) than for the decoction.
ISSN: 0378-8741

hal-01313006
http://hal.upmc.fr/hal-01313006
http://hal.upmc.fr/hal-01313006/document
http://hal.upmc.fr/hal-01313006/file/Houel_Wayanin_and.pdf
DOI : 10.1016/j.jep.2016.04.053

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
We studied the patterns, rates and evolution of fluvial terraces and fault system during the building process of an intracontinental transpressional mountain in the Gobi-Altay (Mongolia). By analyzing incisions and offsets of fluvial terraces and alluvial fans, we show that the massif has grown by outward migration of thrust faults through time. On the northern flank, the present bounding thrust fault began its activity ~600 ka ago, while a more internal sub-parallel fault was still active until ~200-100 ka. Vertical offset of an alluvial fan abandoned ~100 ka ago allows an estimate of 0.1 mm/yr Upper Pleistocene - Holocene uplift rate. The morphology of the catchment-piedmont system strongly suggests a periodical formation of the alluvial surfaces, controlled by the climatic pulses, at the beginning of the wet interglacial periods. The abandonment of the alluvial terraces lags by several thousand years the abandonment of the alluvial fans, showing a diachronous incision propagating upstream. The incision rate deduced from the different elevations of straths exceeds of one order of magnitude the rock uplift rate. This excess is mostly due to ongoing drainage network growth at the core of the massif, and incision due to alluvial apron entrenchment near the outlet. This implies that fluvial response is mainly controlled by drainage growth, interaction with piedmont and cyclic climatic variations, rather than by rock uplift.
ISSN: 0278-7407

hal-00323558
https://hal.archives-ouvertes.fr/hal-00323558
https://hal.archives-ouvertes.fr/hal-00323558v2/document
https://hal.archives-ouvertes.fr/hal-00323558/file/Vassallo2007.pdf
DOI : 10.1029/2006TC002081

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Although ants may induce community-wide effects via changes in physical habitats in terrestrial environments, their influence on aquatic communities living in plant-held waters remains largely underexplored. The neotropical tank-bromeliad Aechmea mertensii (Bromeliaceae) occurs along forest edges in ant-gardens initiated by Camponotus femoratus or by Pachycondyla goeldii. Its leaves form wells that hold rainwater and provide suitable habitats for many aquatic organisms. We postulated that these ant-plant mutualisms indirectly affect the microbial community structure via changes in the environmental conditions experienced by the plants. To test this hypothesis, we analyzed the protist communities from 63 tank-bromeliads associated with either C. femoratus or P. goeldii (hereafter Cf-Aechmea and Pg-Aechmea) along a forest edge in French Guiana. For each plant, a large number of environmental variables (including habitat structure, food resources, incident radiation and the presence of aquatic invertebrates) were quantified to determine their relative importance in driving any observed differences across ant-associated plants. Pg-Aechmea are located in sun-exposed areas and hold low volumes of water and low amounts of detritus, whereas Cf-Aechmea are located in partially shaded areas and accumulate higher amounts of water and detritus. Protists (i.e., protozoa and algae) inhabiting Cf-Aechmea exhibit greater richness and abundances than those in Pg-Aechmea. Variations in detritus content, number of leaves, incident radiation, and the epiphyte richness of the ant-garden were the main factors explaining the variation in protist richness. A shift in the functional group composition of protists between bromeliads tended by different ant species suggested that mutualistic ants indirectly mediate changes in the microbial food web.
Basic and Applied Ecology

hal-00913126
https://hal.archives-ouvertes.fr/hal-00913126
https://hal.archives-ouvertes.fr/hal-00913126/document
DOI : 10.1016/j.baae.2012.10.002
OATAO : 10190

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Zelus annulosus is an assassin bug species mostly noted on Hirtella physophora, a myrmecophyte specifically associated with the ant Allomerus decemarticulatus known to build traps on host tree twigs to ambush insect preys. The Z. annulosus females lay egg clutches protected by a sticky substance. To avoid being trapped, the first three instars of nymphs remain grouped in a clutch beneath the leaves on which they hatched, yet from time to time, they climb onto the upper side to group ambush preys. Long-distance prey detection permits these bugs to capture flying or jumping insects that alight on their leaves. Like some other Zelus species, the sticky substance of the sundew setae on their forelegs aids in prey capture. Group ambushing permits early instars to capture insects that they then share or not depending on prey size and the hunger of the successful nymphs. Fourth and fifth instars, with greater needs, rather ambush solitarily on different host tree leaves, but attract siblings to share large preys. Communal feeding permits faster prey consumption, enabling small nymphs to return sooner to the shelter of their leaves. By improving the regularity of feeding for each nymph, it likely regulates nymphal development, synchronizing molting and subsequently limiting cannibalism.
ISSN: 0028-1042

hal-01091981
https://hal.archives-ouvertes.fr/hal-01091981
https://hal.archives-ouvertes.fr/hal-01091981/document
https://hal.archives-ouvertes.fr/hal-01091981/file/Dejean_11543.pdf
DOI : 10.1007/s00114-013-1091-9

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: Phthalic acid esters are widely used in the manufacture of plastics. Numerous studies have shown that these phthalates impair testicular testosterone production in the rat. However, the scarce and contradictory data concerning humans have cast doubt over whether these compounds are also anti-androgenic in man. We therefore investigated the direct effects of di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) on organo-cultured adult human testis and a human cell line. METHODS: Adult human testis explants or NCI-H295R adrenocortical human cells were cultured with DEHP or MEHP. The effects of ketoconazole, used as a reference molecule, were also assessed. RESULTS: In both models, DEHP and MEHP significantly inhibited testosterone production. The effects of both phthalates appeared to be specific for steroidogenesis, as INSL3 production by Leydig cells was not altered. Furthermore, the phthalates of interest had no effect on inhibin B production by Sertoli cells or on germ cell apoptosis. As only a small fraction of the phthalates added was found in the testis explants, and as these compounds were found to be metabolized, we estimate that the anti-androgenic effects observed occurred at concentrations of phthalates that are of the same order of magnitude as exposures reported in the literature for men. CONCLUSIONS: We provide the first evidence that DEHP and MEHP can inhibit testosterone production in the adult human testis. This is consistent with recent epidemiological findings of an inverse correlation between exposure to MEHP and testosterone concentrations.
ISSN: 0268-1161

hal-00876965
https://hal.archives-ouvertes.fr/hal-00876965
DOI : 10.1093/humrep/des069
PUBMED : 22402212

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
We provide new constraints on the modes of mantle exhumation and denudation in the pre-orogenic Pyrenees by investigating the poorly known peridotites located east of the Lherz body, in eastern Ariè ge (Vicdessos, Urs, Bestiac, Caussou and Prades main peridotitic bodies). We show that: (1) numerous peridotite bodies, not described so far, are constituted by decametric to sub-metric outcrops scattered between and around the main outcrops identified by Monchoux (1970); (2) most of the peridotites form blocks and lenses of various sizes, from millimetric monocrystalline grains to hectometric olistoliths, embedded in debris flows involving mainly Mesozoic metasediments; these peridotites can therefore be linked to the S-type peridotites of Lagabrielle et al. (2010), and share similarities with the peridotites of Lherz region (Clerc et al., 2012). All originated from tectono-sedimentary processes associated with mantle exhumation in relation with extreme thinning and breakoff of the continental basement; (3) the various petrographic characters of these peridotites and their heterogeneity in serpentinisation degree imply a peculiar mode of exhumation, which merges mantle fragments inherited from different structural levels; (4) the lack of tectonic structures such as faults and shear planes associated with the ultramafic-rich breccia formation and the presence of neoformation of metamorphic minerals within the matrix preclude their origin as cataclasites related to the Latest Cretaceous and Tertiary Pyrenean contractional deformation. The peridotites of eastern Ariè ge are indisputable witnesses of the presence of an inverted hyper-extended Cretaceous passive margin forming the current North Pyrenean zone. The geometry of the extensional system was complex and probably associated with strike-slip faults and transcurrent motion. ß 2016 The Authors. Published by Elsevier Masson SAS on behalf of Acadé mie des sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).
ISSN: 1631-0713

Droits : http://creativecommons.org/licenses/by-nc-nd/
insu-01280502
https://hal-insu.archives-ouvertes.fr/insu-01280502
https://hal-insu.archives-ouvertes.fr/insu-01280502/document
https://hal-insu.archives-ouvertes.fr/insu-01280502/file/1-s2.0-S1631071316000043-main.pdf
DOI : 10.1016/j.crte.2015.12.003

Éditeur(s) : HAL CCSD
Résumé : International audience
GEOBIA 2012
Rio de Janeiro, France

hal-01107866
https://hal.archives-ouvertes.fr/hal-01107866