Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The contourite depositional system (CDS) along the southwestern Iberian Margin (SIM), within the Gulf of Cadiz and offshore areas of western Portugal bear the unmistakable signal of Mediterranean Outflow Water (MOW) exiting the Strait of Gibraltar. This locality records key information concerning the effects of tectonic activity on margin sedimentation, the effects of MOW dynamics on Atlantic circulation, and how these factors may have influenced global climate. Over the last four decades, numerous studies have been conducted on the late Miocene, Pliocene and Quaternary sedimentary stacking pattern of Neogene basins along the SIM for both academic and resources exploration purposes. However, understanding of the region rests primarily on basic seismic stratigraphy calibrated with limited data from only a few exploration wells. The Integrated Ocean Drilling Program (IODP) Expedition 339 recently drilled five sites in the Gulf of Cadiz and two sites on the western Iberian margin. The integration of core and borehole data with other geophysical databases leads us to propose a new stratigraphic framework. Interpretation of IODP Exp. 339 data along with that from industry sources and onshore outcrop analysis helps refine our understanding of the SIM's sedimentary evolution.We identify significant changes in sedimentation style and dominant sedimentary processes, coupled with widespread depositional hiatuses along the SIM within the Cadiz, Sanlucar, Doñana, Algarve and Alentejo basins. Following the 4.5 Ma cessation of a previous phase of tectonic activity related to the Miocene–Pliocene boundary, tectonics continued to influence margin development, downslope sediment transport and CDS evolution. Sedimentary features indicate tectonic pulses of about 0.8–0.9 Ma duration with a pronounced overprint of ~ 2–2.5 Ma cycles. These more protracted cycles relate to the westward rollback of subducted lithosphere at the convergent Africa-Eurasia plate boundary as its previous NW–SE compressional regime shifted to a WNW–ESE direction. Two major compressional events affecting to the Neogene basins at 3.2–3 Ma and 2–2.3 Ma help constrain the three main stages of CDS evolution. The stages include: 1) the initial-drift stage (5.33–3.2 Ma) with a weak MOW, 2) a transitional-drift stage (3.2–2 Ma) and 3) a growth-drift stage (2 Ma-present time) with enhanced MOW circulation into the Atlantic and associated contourite development due to greater bottom-current velocity. Two minor Pleistocene discontinuities at 0.7–0.9 Ma and 0.3–0.6 Ma record the effects of renewed tectonic activity on basin evolution, appearing most prominently in the Doñana basin. Several discontinuities bounding major and minor units appear on seismic profiles. Quaternary records offer the clearest example of this, with major units of about 0.8–0.9 Ma and sub-units of 0.4–0.5 Ma. Sedimentation is controlled by a combination of tectonics, sediment supply, sea-level and climate. This research identifies time scales of tectonic controls on deep-marine sedimentation, specifically over periods of 2.5–> 0.4 Ma. Shorter-term climatic (orbital) mechanisms control sedimentation at time scales of ≤ 0.4 Ma. The role of bottom water circulation and associated processes in shaping the seafloor and controlling the sedimentary stacking pattern on continental margins has to be seriously reconsidered in future multidisciplinary studies. This is not only because of the common occurrence of sandy contourite deposits in deep water setting and their economic interest for hydrocarbon exploration, but principally because they archive the heartbeat of the interior Earth and therefore have important sedimentary and paleoceanographic implications.
ISSN: 0025-3227

hal-01356166
https://hal.archives-ouvertes.fr/hal-01356166
DOI : 10.1016/j.margeo.2015.09.013

Éditeur(s) : HAL CCSD Springer
Résumé : International audience
This contribution is an attempt to present a self-contained and comprehensive survey of the mathematics and physics of material behavior of rocks in terms of texture and anisotropy. Being generally multi-phase and poly-crystalline, where each single crystallite is anisotropic with respect to its physical properties, texture, i.e., the statistical and spatial distribution of crystallographic orientations becomes a constitutive characteristic and determines the material behavior except for grain boundary effects, i.e., in first order approximation. This chapter is in particular an account of modern mathematical texture analysis, explicitly clarifying terms, providing definitions and justifying their application, and emphasizing its major insights. Thus, mathematical texture analysis is brought back to the realm of spherical Radon and Fourier transforms, spherical approximation, spherical probability, i.e., to themathematics of spherical tomography
Handbook of Geomathematics

hal-00564939
https://hal.archives-ouvertes.fr/hal-00564939

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ISSN: 0022-2720

hal-01682104
https://hal.univ-antilles.fr/hal-01682104
DOI : 10.1046/j.1365-2818.2003.01170.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Tsavorite, the vanadian variety of green grossular, is a high value economic gemstone. It is hosted exclusively in the metasedimentary formations from the Neoproterozoic Metamorphic Mozambique Belt. The deposits are mined in Kenya, Tanzania and Madagascar and other occurrences are located in Pakistan and East Antarctica. They are located within metasomatized graphitic rocks such as graphitic gneiss and calc-silicates, intercalated with meta-evaporites. Tsavorite is found as primary deposits either in nodule (type I) or in quartz vein (type II), and in placers (type III). The primary mineralizations (types I and II) are controlled by lithostratigraphy and/or structure. For the African occurrences, the protoliths of the host-rocks were deposited at the beginning of the Neoproterozoic within a marine coastal sabkha environment, located at the margin of the Congo-Kalahari cratons in the Mozambique Ocean. During the East African-Antarctican Orogeny, the rocks underwent high amphibolite to granulite facies metamorphism and the formation of tsavorite deposits occurred between 650 and 550 Ma. The nodules of tsavorite were formed during prograde metamorphism, calcium coming from sulphates and carbonates, whereas alumina, silicates, vanadium and chromium probably came from clays and chlorite. The veins were formed during the deformation of the metasedimentary platform units which experienced shearing, leading to the formation of fault-filled veins. Metasomatism developed during retrograde metamorphism. The metasedimentary sequences are characterized by the presence of evaporitic minerals such as gypsum and anhydrite, and scapolite. Evaporites are essential as they provide calcium and permit the mobilization of all the chemical elements for tsavorite formation. The H2S-S8 metamorphic fluids characterized in primary fluid inclusions of tsavorites and the δ11B values of coeval dravite confirm the evaporitic origin of the fluids. The V2O3 and Cr2O3 contents of tsavorite range respectively from 0.05 to 7.5 wt.%, while their δ18O values are in the range of 9.5-21.1‰. The genetic model proposed for tsavorite is metamorphic, based on chemical reactions developed between an initial assemblage composed of gypsum and anhydrite, carbonates and organic matter deposited in a sabkha-like sedimentary basin.
ISSN: 0169-1368

hal-00853279
https://hal.archives-ouvertes.fr/hal-00853279
DOI : 10.1016/j.oregeorev.2013.01.016

Éditeur(s) : HAL CCSD
Résumé : International audience
L’asthme chez les agriculteurs est un phénomène contradictoire, puisque le milieu agricole est à la fois décrit comme étant à risque d’asthme inflammatoire et comme étant protecteur d’asthme allergique.Une étude ancillaire d’AIRBAg (Analyse Incidence et facteurs de Risque de BPCO Agricole) a permis l’analyse de 603 agriculteurs laitiers d’Ille et Vilaine et du Morbihan, afin de définir la prévalence de l’asthme dans cette population, et d’identifier des facteurs de risque et/ou protecteurs de la maladie asthmatique. Pour cela, les patients asthmatiques ont été comparés au reste de la population agricole selon des critères cliniques, professionnels et environnementaux.Nous avons mis en évidence une prévalence de 6 % d’asthme. Aucun facteur professionnel n’était significativement associé au risque d’être asthmatique. Il semble que les facteurs protecteurs principaux soient pour la plupart retrouvés dans notre population d’asthmatique, hormis l’allaitement maternel, présent chez seulement un quart des patients.La prévalence de l’asthme dans notre cohorte d’agriculteur est donc semblable à celle de la population générale, et l’asthme est la maladie obstructive la plus fréquente dans l’échantillon. Aucun facteur professionnel n’a été identifié comme facteur de risque.
Revue des Maladies Respiratoires
Lille, France

hal-01122830
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122830
DOI : 10.1016/j.rmr.2014.10.695

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The high proportion of crystallized apatite forming the bones and teeth should theoretically allow the use of fission track analysis to date vertebrate fossils when burying of the fossiliferous series did not subject them to temperatures exceeding 60 degrees C. However several major obstacles arise such as the complexity of fossils' internal structures, diagenetic modifications and substitutions of the hydroxyapatite by other minerals, and massive U uptake or loss during diagenesis. In this work, those various problems are addressed combining optical microscope observation of the fossils, a systematic fission track analysis of the best samples, alpha and gamma spectrometry and Secondary Ion Mass Spectrometry. Even if the problems caused by internal structures and mineral substitutions can be solved, U movements in and out of the fossils are generally too complex to allow fission track analysis dating of the fossils.
ISSN: 0009-2541

hal-00411880
https://hal.archives-ouvertes.fr/hal-00411880
DOI : 10.1016/j.chemgeo.2007.10.009

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Moore proposes in his Comment (Moore, 2017) that marginal zones in olivine grains in kimberlites (Fig. 1a) are produced by crystallization from kimberlite melt. He suggests that the chemical zones observed in these marginal zones (inner transition zones and outer margins, illustrated in his fig. 1) result from abrupt changes in distribution coefficients during crystallization. He proposes that the transition zones, characterized by variable Fo at constant and high Ni contents, are produced by crystallization with high KdFe–Mg (= 0·45) and low DNi (= 4) whereas the margins, characterized by a sharp drop in Ni content at nearly constant Fo (Fig. 1b), are produced by crystallization with higher DNi owing to a sudden change in physical conditions of crystallization (P,...
ISSN: 0022-3530

hal-01685633
https://hal.archives-ouvertes.fr/hal-01685633
DOI : 10.1093/petrology/egx013

Éditeur(s) : HAL CCSD
Résumé : International audience
Necroptosis is a regulated form of cell death involved in several disease models including in particular liver diseases. Receptor-interacting protein kinases, RIPK1 and RIPK3, are the main serine/threonine kinases driving this cell death pathway. We screened a noncommercial, kinase-focused chemical library which allowed us to identify Sibiriline as a new inhibitor of necroptosis induced by tumor necrosis factor (TNF) in Fas-associated protein with death domain (FADD)-deficient Jurkat cells. Moreover, Sib inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis. By using competition binding assay and recombinant kinase assays, we demonstrated that Sib is a rather specific competitive RIPK1 inhibitor. Molecular docking analysis shows that Sib is trapped closed to human RIPK1 adenosine triphosphate-binding site in a relatively hydrophobic pocket locking RIPK1 in an inactive conformation. In agreement with its RIPK1 inhibitory property, Sib inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis. Finally, Sib protects mice from concanavalin A-induced hepatitis. These results reveal the small-molecule Sib as a new RIPK1 inhibitor potentially of interest for the treatment of immune-dependent hepatitis. © 2017 Federation of European Biochemical Societies
ISSN: 1742464X

hal-01616420
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616420
DOI : 10.1111/febs.14176
PUBMED : 28715128

Éditeur(s) : HAL CCSD
Résumé : National audience
Introduction Les données sur l’efficacité virologique et la tolérance à long terme de l’association abacavir/lamivudine (ABC/3TC) et nevirapine (NVP) sont rares.
Médecine et maladies infectieuses 46 (2016) 5-7
Lille, France

Droits : info:eu-repo/semantics/OpenAccess
inserm-01414591
http://www.hal.inserm.fr/inserm-01414591
http://www.hal.inserm.fr/inserm-01414591/document
http://www.hal.inserm.fr/inserm-01414591/file/2016%2C%20de%20Boissieu%20-%20COL%203-04.pdf
PUBMED : 27495405

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Among pregnant women ibuprofen is one of the most frequently used pharmaceutical compounds with up to 28% reporting use. Regardless of this, it remains unknown whether ibuprofen could act as an endocrine disruptor as reported for fellow analgesics paracetamol and aspirin. To investigate this, we exposed human fetal testes (7-17 gestational weeks (GW)) to ibuprofen using ex vivo culture and xenograft systems. Ibuprofen suppressed testosterone and Leydig cell hormone INSL3 during culture of 8-9 GW fetal testes with concomitant reduction in expression of the steroidogenic enzymes CYP11A1, CYP17A1 and HSD17B3, and of INSL3. Testosterone was not suppressed in testes from fetuses younger than 8 GW, older than 10-12 GW, or in second trimester xenografted testes (14-17 GW). Ex vivo, ibuprofen also affected Sertoli cell by suppressing AMH production and mRNA expression of AMH, SOX9, DHH, and COL2A1. While PGE2 production was suppressed by ibuprofen, PGD2 production was not. Germ cell transcripts POU5F1, TFAP2C, LIN28A, ALPP and KIT were also reduced by ibuprofen. We conclude that, at concentrations relevant to human exposure and within a particular narrow â €' early window' of sensitivity within first trimester, ibuprofen causes direct endocrine disturbances in the human fetal testis and alteration of the germ cell biology. © The Author(s) 2017.
ISSN: 2045-2322

hal-01517095
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01517095
DOI : 10.1038/srep44184
PUBMED : 28281692

Éditeur(s) : HAL CCSD
Résumé : 17 pages
We look at the number of solutions of an equation of the form f_1*f_2*...*f_k=a in a finite field, where each f_i is a multilinear polynomial. We use two methods to construct a solution of this problem for the cases a=0, a<>0, and we generally get a semi-explicit formula. We show that this formula can generate a more efficient algorithm than the traditional algorithm which consists to make a systematic computation. We also give explicit formulas in some special cases, and an application of our main result to the search of the weight hierarchy of the multilinear code with separated variables.
https://hal.univ-antilles.fr/hal-00772478

hal-00772478
https://hal.univ-antilles.fr/hal-00772478
ARXIV : math.NT/0603057

Éditeur(s) : HAL CCSD National Academy of Sciences
Résumé : International audience
ISSN: 0027-8424

halsde-00335837
https://hal.archives-ouvertes.fr/halsde-00335837
DOI : 10.1073/pnas.0708015105

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : absent
ISSN: 0168-1923

hal-01032365
https://hal.archives-ouvertes.fr/hal-01032365

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Prediction of ice mass flow and associated dynamics is pivotal at a time of climate change. Ice flow is dominantly accommodated by the motion of crystal defects – the dislocations. In the specific case of ice, their observation is not always accessible by means of the classical tools such as X-ray diffraction or transmission electron microscopy (TEM). Part of the dislocation population, the geometrically necessary dislocations (GNDs) can nevertheless be constrained using crystal orientation measurements via electron backscattering diffraction (EBSD) associated with appropriate analyses based on the Nye (1950) approach. The present study uses the Weighted Burgers Vectors, a reduced formulation of the Nye theory that enables the characterization of GNDs. Applied to ice, this method documents, for the first time, the presence of dislocations with non-basal or Burgers vectors. These or dislocations represent up to of the GNDs observed in laboratory-deformed ice samples. Our findings offer a more complex and comprehensive picture of the key plasticity processes responsible for polycrystalline ice creep and provide better constraints on the constitutive mechanical laws implemented in ice sheet flow models used to predict the response of Earth ice masses to climate change.
ISSN: 0012-821X

hal-01685565
https://hal.archives-ouvertes.fr/hal-01685565
DOI : 10.1016/j.epsl.2017.06.020

Éditeur(s) : HAL CCSD Wiley
Résumé : absent
ISSN: 0140-7791

hal-01032203
https://hal.archives-ouvertes.fr/hal-01032203

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Varicella zoster virus (VZV) is a leading cause of acute viral encephalitis but little is known about its clinical, biological and imaging features. Furthermore, the most favourable treatment regimen has not been determined. We studied a prospective cohort of 20 HIV-negative patients presenting with acute VZV encephalitis caused by primary infection or reactivation. VZV was identified in 16 of 20 cases by PCR detection of the DNA in the cerebrospinal fluid. The four remaining cases occurred during or soon after a VZV rash. The median age of the 17 adults was 76 (19-86) years; the three other patients were children (0.5-5 years). Three patients were immunocompromised. Nine adult patients presented with a rash. Eighteen patients presented with fever and an acute encephalitic syndrome: diffuse brain dysfunction, focal neurological signs, seizures and cranial nerve palsies. Three patients presented with either ventricular or subdural haemorrhage, one with myelitis, and one with asymptomatic stenosis of the middle cerebral artery. The imaging was either normal or revealed non-specific abnormalities such as cortical atrophy but no evidence of stroke. All patients were given acyclovir at various dosages and durations but the case fatality rate remained high (15%) and sequelae were frequently observed either at discharge or at follow-up 3 years later.
ISSN: 1198-743X

hal-00875232
https://hal.archives-ouvertes.fr/hal-00875232
PUBMED : 22085160
DOI : 10.1111/j.1469-0691.2011.03705.x

Éditeur(s) : HAL CCSD IOP Publishing
Résumé : The Bureau International des Poids et Mesures (BIPM), Sevres, France, hosted the 7th International Comparison of Absolute Gravimeters (ICAG) and the associated Relative Gravity Campaign (RGC) from August to September 2005.;ICAG 2005 was prepared and performed as a metrological pilot study, which aimed:;(1) To determine the gravity comparison reference values;;(2) To determine the offsets of the absolute gravimeters; and;(3) As a pilot study to accumulate experience for the CIPM Key Comparisons.;This document presents a complete and extensive review of the technical protocol and data processing procedures. The 1st ICAG-RGC comparison was held at the BIPM in 1980-1981 and since then meetings have been organized every 4 years.;In this paper, we present an overview of how the meeting was organized, the conditions of BIPM gravimetric sites, technical specifications, data processing strategy and an analysis of the final results. This 7th ICAG final report supersedes all previously published reports.;Readings were obtained from participating instruments, 19 absolute gravimeters and 15 relative gravimeters. Precise levelling measurements were carried out and all measurements were performed on the BIPM micro-gravity network which was specifically designed for the comparison.
ISSN: 0026-1394

hal-00644529
https://hal.archives-ouvertes.fr/hal-00644529
DOI : 10.1088/0026-1394/48/5/003

Éditeur(s) : HAL CCSD
Résumé : International audience
New inclinometers devoted to hydrological studies were set up in the Vosges Mountains (France). Two orthogonal 100-meter base hydrostatic inclinometers were installed in December 2004 as well as a hydrometeorological monitoring system for the 100-km² hydrological unit around the inclinometer. As inclinometers are very sensitive to environmental influences, this observatory is a test site to confront hydrological modelling and geodetic observations. Physical modelling to remove hydrological effects without calibrating on geodetic data is tested on these instruments. Specifically, two deformation processes are most important: fluid pressure variations in nearby hydraulically active fractures and surface loading at regional scale.
International Association of Geodesy Symposia
Perugia, Italy

hal-00710442
https://hal.archives-ouvertes.fr/hal-00710442
https://hal.archives-ouvertes.fr/hal-00710442/document
https://hal.archives-ouvertes.fr/hal-00710442/file/2007IUGG_proceedingsIAG.pdf
DOI : 10.1007/978-3-540-85426-5_63

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ISSN: 0933-7407

hal-01659242
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01659242
DOI : 10.1111/myc.12674

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
We examine absolute gravity (AG) and vertical Global Positioning System (GPS) time series between 1995 and 2010 at eight collocated sites in mid-continent North America. The comparison of AG and GPS rates aligned to ITRF2005 yields a gravity/uplift ratio of -0.17 +/- 0.01 mu Gal mm(-1) (1 mu Gal = 10 nm s(-2)) and an intercept of -0.1 +/- 0.5 mm yr(-1). In contrast, aligning the GPS velocities to ITRF2000 results in a gravity/uplift intercept of -1.3 +/- 0.5 mm yr(-1). The near-zero gravity/uplift offset for the ITRF2005 (or ITRF2008) results shows a good alignment of the GPS vertical velocities to Earth's center of mass, and confirms that GPS velocities in this reference frame can be compared to predictions of geodynamic processes such as glacial isostatic adjustment (GIA) or sea-level rise. The observed gravity/uplift ratio is consistent with GIA model predictions. The ratio remains constant in regions of fast and slow uplift, indicating that GIA is the primary driving process and that additional processes such as local hydrology have a limited impact on a decadal time-scale. Combining AG and GPS measurements can provide significant constraints for geodetic, geodynamic, and hydrological studies. Citation: Mazzotti, S., A. Lambert, J. Henton, T. S. James, and N. Courtier (2011), Absolute gravity calibration of GPS velocities and glacial isostatic adjustment in mid-continent North America, Geophys. Res. Lett., 38, L24311, doi:10.1029/2011GL049846.
ISSN: 0094-8276

hal-00689010
https://hal.archives-ouvertes.fr/hal-00689010
DOI : 10.1029/2011GL049846