Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Background & Aims: The severity of liver diseases is exacerbated by the death of hepatocytes, which can be induced by the sensing of pathogen associated molecular patterns (PAMPs) derived from the gut microbiota. The molecular mechanisms regulating these cell death pathways are poorly documented. In this study, we investigated the role of the receptor interacting protein kinase 1 (RIPK1), a protein known to regulate cell fate decisions, in the death of hepatocytes using two in vivo models of PAMP-induced hepatitis. Methods: Hepatitis was induced in mice by independent injections of two different bacterial PAMPs: lipopolysaccharide (LPS) and unmethylated CpG oligodeoxynucleotide (CpG-DNA) motifs. The role of RIPK1 was evaluated by using mice specifically lacking RIPK1 in liver parenchymal cells (Ripk1(LPC-KO)). Administration of liposome-encapsulated clodronate served to investigate the role of Kupffer cells in the establishment of the disease. Etanercept, a tumor necrosis factor (TNF)-decoy receptor, was used to study the contribution of TNF-alpha during LPS-mediated liver injury. Results: Whereas RIPK1 deficiency in liver parenchymal cells did not trigger basal hepatolysis, it greatly sensitized hepatocytes to apoptosis and liver damage following a single injection of LPS or CpG-DNA. Importantly, hepatocyte death was prevented by previous macrophage depletion or by TNF inhibition. Conclusions: Our data highlight the pivotal function of RIPK1 in maintaining liver homeostasis in conditions of macrophage-induced TNF burst in response to PAMPs sensing. Lay summary: Excessive death of hepatocytes is a characteristic of liver injury. A new programmed cell death pathway has been described involving upstream death ligands such as TNF and downstream kinases such as RIPK1. Here, we show that in the presence of LPS liver induced hepatic injury was due to secretion of TNF by liver macrophages, and that RIPK1 acts as a powerful protector of hepatocyte death. This newly identified pathway in the liver may be helpful in the management of patients to predict their risk of developing acute liver failure. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
ISSN: 0168-8278

hal-01532060
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01532060
DOI : 10.1016/j.jhep.2017.01.005
PUBMED : 28088582

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Fungi are major contributors to the opportunistic infections that affect patients with HIV/AIDS. Systemic infections are mainly with Pneumocystis jirovecii (pneumocystosis), Cryptococcus neoformans (cryptococcosis), Histoplasma capsulatum (histoplasmosis), and Talaromyces (Penicillium) marneffei (talaromycosis). The incidence of systemic fungal infections has decreased in people with HIV in high-income countries because of the widespread availability of antiretroviral drugs and early testing for HIV. However, in many areas with high HIV prevalence, patients present to care with advanced HIV infection and with a low CD4 cell count or represent with persistent low CD4 cell counts because of poor adherence, resistance to antiretroviral drugs, or both. Affordable, rapid point-of-care diagnostic tests (as have been developed for cryptococcosis) are urgently needed for pneumocystosis, talaromycosis, and histoplasmosis. Additionally, antifungal drugs, including amphotericin B, liposomal amphotericin B, and flucytosine, need to be much more widely available. Such measures, together with continued international efforts in education and training in the management of fungal disease, have the potential to improve patient outcomes substantially.
ISSN: 1473-3099

inserm-01574426
http://www.hal.inserm.fr/inserm-01574426
http://www.hal.inserm.fr/inserm-01574426/document
http://www.hal.inserm.fr/inserm-01574426/file/2017%2C%20Limper%20-%20Fungal%20infections%20in%20HIV%20AIDS.pdf
DOI : 10.1016/S1473-3099(17)30303-1

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Cyanobacteria and cyanotoxins have been more and more studied during the last decades with regard to environment and health issues. More recently the consequences of climate change reinforced the need for research in view of a better management of cyanobacteria blooms. In this context the exploitation of the water quality survey of 26 recreational lakes in Brittany (north western France) between 2004 and 2011 is reported in this paper in order to encompass spatial and interannual patterns of cyanobacteria development at a regional scale. Starting from weekly data principally acquired during summertime, the links between cyanobacteria cell densities, toxin occurrences and interannual meteorological factors can give insights on the potential evolution of cyanobacterial crisis in the future. This study is part of a project aiming at a better understanding of potentially toxic cyanobacteria crisis occurrences in recreational waters, in order to improve predictive monitoring routines.
Environment International

hal-00877892
https://hal.archives-ouvertes.fr/hal-00877892
https://hal.archives-ouvertes.fr/hal-00877892/document
DOI : 10.1016/j.envint.2013.09.018

Éditeur(s) : Edp Sciences S A
Résumé : Moored FADs (MFADs) have been a key area for development in Guadeloupe (Lesser Antilles) since the late 1980's. The main objectives underpinning the development of MFADs were to (i) reduce fishing pressure on coastal fishing resources; (ii) boost fishermen's incomes; and (iii) increase local consumption of locally generated fishery products as a proportion of overall consumption. This paper gives an overview of the current structure of Guadeloupe's fishing fleet and fisheries, with a specific focus on MFAD fleets in a relatively unstructured environment with regard to regulation, and so how these fleets operate in a context of unrestricted development of private MFADs. In addressing the following key issues, this paper aims to: assess the economic performance of fleets operating on MFADs, understand why the MFAD fishing activity has not developed more than it has, and suggest how better MFAD management could improve the situation. Socio-economic information on a trip and fleet level basis were collected and stored on a fisheries information system to analyse the relative attractiveness of MFAD fishing and assess the overall economic performance of MFAD fleets as compared to other non-MFAD fleets. Non-monetary variables were also tested to explain the degree of dependence on MFADs. In 2008, economic returns from FADs were relatively low, both in terms of wages for the crews and in terms of profit for vessel owners. Earnings were higher than coastal fishing activities, but seem to have been very sensitive to the indicators used in our analysis. MFADs are expected to become much more attractive as a result of MFAD regulation, especially through the establishment of collective MFADs.
Aquatic Living Resources (0990-7440) (Edp Sciences S A), 2013-01 , Vol. 26 , N. 1 , P. 97-105

Droits : EDP Sciences, IFREMER, IRD 2013
http://archimer.ifremer.fr/doc/00137/24836/22914.pdf
DOI:10.1051/alr/20013044
http://archimer.ifremer.fr/doc/00137/24836/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Decreasing growth rate (Feeley et al., 2007) and large die-back due to drought (Phillips et al., 2009) suggest that tropical forests are suffering recent climate changes. Forest vulnerability to external factors (e.g. air pollution, acid rain) is widely studied in northern countries, while only a few attempts have investigated crown integrity in the Tropics. The method needs to be generic enough to account for the large number of species and crown shapes encountered in tropical forests. In the present study, we developed and tested a novel field method that estimates crown fragmentation (main branch mortality (MB) and secondary branch mortality (SB)), liana infestation (LI) and crown position (CP) in the canopy. The relationship between crown fragmentation and annual growth rate (agr) was investigated through multiple regression. Six out of eight canopy tree species showed significant growth decline with increasing crown fragmentation. Higher probability of death was also found in trees with severe crown fragmentation. The capacity of such crown assessment to depict tree vitality in a forest stand is discussed along with potential applications in both forest science and management
ISSN: 0378-1127

halsde-00611465
https://hal.archives-ouvertes.fr/halsde-00611465
DOI : 10.1016/j.foreco.2010.10.025

Éditeur(s) : HAL CCSD Thai Society of Higher Education Institutes on Environment
Résumé : International audience
Due to the high level of endemic species that they support and the high threats they are facing, such as unsustainable limestone quarrying, hunting and urbanization, limestone karsts are recognized as biodiversity hotspots needing urgent protection. The first aim of our study was to investigate the mammal rodent diversity of Thai limestone karsts. Our second aim was to examine the diversity at a finer scale than the species level (intraspecific biodiversity) using phylogeographic approaches. Therefore, we studied the phylogeographic structure of a threatened rodent, endemic to limestone karsts of Thailand, the Murinae Leopoldamys neilli. We sampled 76 limestone karsts in whole Thailand and live-trapped 444 rodents including 115 Leopoldamys neilli. Our study revealed an important rodent diversity in Thai limestone karsts. Besides endemic rodent species, karsts also host typical forest species to which they provide forest refugia in deforested regions. At the intraspecific level, our study revealed an unexpected high level of genetic differentiation within the rodent species L. neilli. As each limestone area of Thailand is characterized by a particular genetic lineage of L. neilli, the destruction of these karsts would lead to the disappearance of unique intraspecific strains not found elsewhere. Our results highlight the importance of protecting limestone habitats to preserve not only their interspecific but also intraspecific rodent diversity that is highly threatened as more than 20% of limestone karsts in Thailand have already been quarried. Management plans of limestone, a non-renewable resource, should urgently take into account this high biological importance of karsts.
The 1st EnvironmentAsia International Conference on "Environmental Supporting in Food and Energy Security: Crisis and Opportunity"
Bangkok, Thailand

ird-00714455
http://hal.ird.fr/ird-00714455
http://hal.ird.fr/ird-00714455/document
IRD : fdi:010056152

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Increasingly frequent severe coral bleaching is among the greatest threats to coral reefs posed by climate change. Global climate models (GCMs) project great spatial variation in the timing of annual severe bleaching (ASB) conditions; a point at which reefs are certain to change and recovery will be limited. However, previous model-resolution projections (~1 × 1°) are too coarse to inform conservation planning. To meet the need for higher-resolution projections, we generated statistically downscaled projections (4-km resolution) for all coral reefs; these projections reveal high local-scale variation in ASB. Timing of ASB varies >10 years in 71 of the 87 countries and territories with >500 km 2 of reef area. Emissions scenario RCP4.5 represents lower emissions mid-century than will eventuate if pledges made following the 2015 Paris Climate Change Conference (COP21) become reality. These pledges do little to provide reefs with more time to adapt and acclimate prior to severe bleaching conditions occurring annually. RCP4.5 adds 11 years to the global average ASB timing when compared to RCP8.5; however, >75% of reefs still experience ASB before 2070 under RCP4.5. Coral reef futures clearly vary greatly among and within countries, indicating the projections warrant consideration in most reef areas during conservation and management planning.
ISSN: 2045-2322

hal-01441969
https://hal-univ-perp.archives-ouvertes.fr/hal-01441969
https://hal-univ-perp.archives-ouvertes.fr/hal-01441969/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01441969/file/local%20scale.pdf
DOI : 10.1038/srep39666

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : El turismo náutico se concibe como un segmento estratégico para el desarrollo turístico de España y sus destinos costeros. En Canarias existe una apuesta pública por la especialización del Archipiélago y su reposicionamiento como destino líder europeo de escala en el Atlántico, por las múltiples cualidades naturales que posee la región para el deporte náutico, y su posición geográfica estratégica en el cruce desde Europa hacia el Caribe. Así, se viene planteando una renovación y desarrollo del sector de la náutica de recreo y el turismo de yates, con estrategias enfocadas a la diversificación y el crecimiento. Los altos costes sociales y medioambientales asociados a este tipo de desarrollo justifican la necesidad de una mayor atención académica, que permita comprender las particularidades y complejidades de la actividad y este mercado turístico. En la misma medida en que esta actividad es vista como un factor de riesgo para el medioambiente, la comunidad local y la franja litoral, también son crecientes las preocupaciones y sensibilidad por parte de los turistas hacia estos fenómenos. Dada la carencia de investigaciones en el área, este estudio se propone identificar los determinantes de la satisfacción de los navegantes europeos con los puertos de escala de Canarias. Como resultado de encuestar a 185 navegantes europeos durante su escala en seis puertos deportivos del archipiélago en 2014 y 2015, y la validación de un sistema de ecuaciones estructurales, se ha podido demostrar, entre otros aspectos, que existe una predilección en el mercado de navegantes europeos por presenciar esfuerzos y políticas de gestión ambiental sostenible en las marinas, siendo éste un factor determinante de su satisfacción. Los hallazgos permiten elaborar una serie de recomendaciones a gestores y operadores turísticos del sector, en aras de contribuir al diseño de estrategias que garanticen un desarrollo más sostenible y razonable de la actividad, basados en el efecto positivo que producen estas estrategias en la demanda, y el potencial valor de diferenciación turística que otorga, en el entorno competitivo del sector.
The nautical activiity has great potential for the socio-economic development of tourism. In Spain, the sector is a priority concern, especially for the Canary Islands, which show a clear commitment to specialise and reposition the destination as a top quality nautical destination on a European level. These aspects, together with the prior experience and tradition these islands have as a stopover destination for vessels in the Atlantic, when crossing Europe towards the Caribbean, represent strengths that have not yet been taken advantage of in the archipelago’s attempt to move away from its image as a traditional sun and beach destination. The Governmental Authorities in the Canary Islands have clear strategies in place to promote the yachting tourism growth. However, renewing the sector is believed to be a difficult process because of the large number of factors that interact within the same. This is a phenomenon of sufficient social and environmental significance to justify academic attention. This research analyses therefore the determinants of the European yachtsmen´s satisfaction with the ports of call of the Canary Islands. Data results of questioning 185 European yachtsmen crossing the Atlantic during 2014 and 2015 reveal that, among other aspects, proper environmental management of marinas leads to an increasing yachtsmen´s satisfaction. The findings provide the opportunity for developing recommendations for tourism managers and practitioners, in the attempt to contribute to a more sustainable and reasoned development and growth in the sector. Based on the current preferences of the European market of yachtsmen, it is possible to assure that environmental and social responsibility policies are a key differentiation factor for the competitiveness of the sector.
Canaries

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.10584
http://journals.openedition.org/etudescaribeennes/10584

Éditeur(s) : HAL CCSD Springer International Publishing
Résumé : Industrial agriculture has clearly reached its limits. Industrial agriculture is not able anymore to satisfy the basic needs of the growing worldwide population while ensuring the conditions of reproduction of natural assets. New production models have to be designed to protect and reclame polluted and degraded agricultural areas. Agroecology is considered as a promising way to achieve ecologically-intensive agrosystems, since the seminal contribution of Altieri in 1995. Nevertheless agroecology has not fully emerged as a scientific discipline yet. Agroecology is more that a traditional scientific discipline because agroecology breaks the frontiers between biophysical sciences and social sciences. This chapter reviews the roots and evolution of agroecology in the first section. Here we propose a mathematical theory of viability to handle uncertainty and complexity within agrosystems. This theory allows to define a kern of viability in which the agrosystem stay viable in the long term (section “Scientific stakes: New frontiers”). However, agroecological innovations create new uncertainties and controversies that must be solved. Some solutions can be found individually while other solutions must by co-constructed using innovative collective actions and hydrid forums (Callon et al. 2001, section “Scientific controversy and uncertainty”). Such collective knowledge makes agroecology as the starting point of a representative democracy by setting up adaptive governance on territories (section “How to manage agrosystems in the context of global changes?”).
Sustainable Agriculture Reviews 14

ISBN : 978-3-319-06015-6
hal-01195372
https://hal.archives-ouvertes.fr/hal-01195372
DOI : 10.1007/978-3-319-06016-3_1
PRODINRA : 270790

Éditeur(s) : HAL CCSD
Résumé : International audience
Au cours de l'année 2014, de nouvelles données publiées dans la BPCO vont nous permettre d'améliorer la prise en charge de nos patients. Le retrait progressif des corticoïdes inhalés (CSI) sous couvert d'une double bronchodilatation en traitement de fond (étude WISDOM) n'a pas été accompagné d'une majoration des exacerbations. Une étude transversale rétrospective canadienne a montré l'intérêt tout particulier des CSI chez les patients de plus de 65 ans. Un travail soulignait l'intérêt probable de la corticothérapie systémique lors des exacerbations traitées par ventilation mécanique, invasive ou non. L'étude COLUMBUS a confirmé l'intérêt des macrolides avec une indication privilégiée de l'azithromycine au long cours chez les patients BPCO présentant des exacerbations fréquentes (≥3/an), ayant un traitement inhalé maximaliste (trithérapie) et sevrés du tabac. Le timing de la réhabilitation respiratoire a été précisé et il semblerait qu'elle ne doive pas être initiée à la phase aiguë (i.e., avant la fin de l'exacerbation chez le patient hospitalisé), ce qui ne remet pas en cause l'intérêt démontré de la réhabilitation respiratoire initiée précocement après exacerbation. Enfin, l'étude STATCOPE retire toute place aux statines dans le traitement de fond des patients atteints de BPCO post-tabagique sans comorbidité cardiovasculaire. Tous ces travaux sont détaillés dans ce manuscrit. , Abstract In 2014 new data on COPD were published that allow us to improve the management of patients. The gradual withdrawal of inhaled corticosteroids (ICS) under the cover of double bronchodilatation in baseline treatment (WISDOM study) was not accompanied by an increase in exacerbations. A Canadian retrospective cross sectional study has shown the particular role of ICS in patients over 65 years old. A study underlined the probable role of systemic corticosteroids during exacerbations treated by mechanical ventilation, invasive or not. The COLUMBUS study confirmed the role of macrolides, in particular azithromycin, in the long term treatment of patients with COPD who have frequent exacerbations (3 or more per year) despite taking maximal inhaled therapy and stopping smoking. The timing of pulmonary rehabilitation has been clarified and it seems that it should not be started in the acute phase (i.e. before the end of the exacerbation in hospitalized patients). This questions the demonstrated role of initiation of pulmonary rehabilitation soon after an exacerbation. Finally, the STATCOPE study removes any place for statins in the baseline treatment of COPD patients without cardiovascular comorbidity. All these studies are detailed in this paper.
Mission CPLF 2015. Congrès de Pneumologie de Langue Française
Denver, United States

hal-01198647
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01198647
DOI : 10.1016/S1877-1203(15)30036-7

Éditeur(s) : HAL CCSD American Society for Microbiology
Résumé : International audience
Human leishmaniasis are widely spread diseases with different clinical forms caused by about 20 species within the Leishmania genus. Leishmania species identification is relevant for therapeutic management and prognosis, especially for cutaneous and muco-cutaneous forms. Several methods are available to identify Leishmania species from culture, but they have not been standardized for the majority of the currently described species, with the exception of MultiLocus Enzyme Electrophoresis. Moreover, these techniques are expensive, time-consuming and not available in all laboratories. Within the last decade, mass spectrometry (MS) has been adapted for microorganism identification, including Leishmania However, no commercial reference mass spectral database is available. In this study, a reference mass spectral library (MSL) for Leishmania isolates, accessible through a free web-based application (mass spectral identification, MSI), was constructed and tested. It includes mass spectral data for 33 different Leishmania species, including species that infect humans, animals and phlebotomine vectors. Four laboratories on two continents evaluated MSI performance using 268 samples of which 231 were Leishmania strains. All Leishmania strains, but one, were correctly identified at least at the complex level. A risk of species misidentification within the L. donovani, L. guyanensis and L. braziliensis complexes was observed, as already reported with other techniques. The tested application was reliable, with identification results comparable to those obtained with reference methods, but with a more favorable cost-efficiency ratio. This free online identification system relies on a scalable database and can be implemented directly in the user's computers.
ISSN: 0095-1137

hal-01571305
https://hal.archives-ouvertes.fr/hal-01571305
DOI : 10.1128/JCM.00845-17
PUBMED : 28724559

Éditeur(s) : HAL CCSD Groupe français de géomorphologie (GFG)
Résumé : International audience
This study aims at assessing the vulnerability of populations in the Pasig-Potrero River basin, who are threatened by the recurrent lahars of Mt Pinatubo volcano (Philippines) in the aftermath of its 1991 eruption. A survey, carried out between February and March 1998, enabled us to define and to map different levels of risk perception, the quality of potential behavioural patterns in the event of further lahars, and attitudes in the event of an evacuation order. It was then possible to work out a classification and to map the patterns of human vulnerability in the study area. This study points out that, while risk perception is quite high, some problems remain, notably concerning the warning systems and the behaviour of the population in the case of an evacuation. Theses results should assist in elaborating risk and disaster scenarios. They are intended to be used for operational purposes in crisis management such as the organization of disaster relief, and in land use planning.
ISSN: 1266-5304

hal-01169334
https://hal.archives-ouvertes.fr/hal-01169334
https://hal.archives-ouvertes.fr/hal-01169334/document
https://hal.archives-ouvertes.fr/hal-01169334/file/article_morfo_1266-5304_2001numéro 7_3_1103.pdf
DOI : 10.3406/morfo.2001.1103

Résumé : L’importance du rôle des petites agricultures dans les processus de sécurité alimentaire et de souveraineté alimentaire est de plus en plus reconnue. A Sainte-Lucie comme en Martinique, un certain nombre d’acteurs s’engagent officiellement pour une agriculture diversifiée s’appuyant sur les préceptes du développement durable. C’est en tenant compte de ce contexte qu’en partie l’idée de réaliser une étude sur la petite agriculture de Sainte-Lucie et de la Martinique a germé. Aussi, le présent travail se veut-il avant tout une contribution au diagnostic de la petite agriculture face à la modernisation des systèmes agricoles intensifs dans chacune de ces deux îles. Il s’agit de mettre à l’évidence les richesses et les insuffisances de cette petite agriculture, mais aussi les atouts et les contraintes de l’environnement. En grande partie elle prend appui sur le jardin créole, système agricole considéré par bien d’acteurs comme un fondement culturel et une base culturale. Dans chacune des deux îles, beaucoup de petits agriculteurs font de la biodiversité une composante primordiale de la gestion de leurs systèmes agricoles. Les enjeux visés ici portent sur la contribution d’une gestion optimale de cette biodiversité à la promotion des agrosystèmes paysans durables à différentes échelles spatio-temporelles. Dès lors, tout dépend des méthodes d’accompagnement des agriculteurs à mettre en œuvre. Va-t-on poursuivre avec des approches descendantes basées sur la logique de transfert ? Si non, le moment n’est-il pas venu de réunir les conditions pouvant permettre la mise en œuvre des véritables démarches de co-construction ?
The important role of small farmers in the process in food security and of food sovereignty is increasingly recognized. In St. Lucia as in Martinique, a number of actors officially committed to a diverse agriculture based on the precepts of sustainable development. It is in the light on this context that partially, the idea of a study on small holder St Lucia and Martinique germinated. Also, the present work is first and foremost a contribution to the diagnosis of small-scale agriculture to modernization of the intensive agricultural systems in each of these two islands. It is put clearly the richness and the inadequacies of this small scale-agriculture, but also the advantages and constraints of the environment. In large part it builds on the creole garden, agricultural system considered by many actors as a cultural foundation and a base of farming practices. In each of the two islands, many small farmers make biodiversity an essential component of management of their farm systems. The stakes referred here relate to the optimal management contribution of biodiversity to promote sustainable peasant agro-ecosystems at different spatial and temporal scales. Therefore, everything depends on farmer coaching methods to set up. Will we continue with down approaches based on logic of transfer ? Otherwise, isn’t time to create the conditions that could allow the development of real co-construction steps ?

http://www.theses.fr/2015AGUY0866/document

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Benthic cyanobacterial mats (BCMs) are impacting coral reefs worldwide. However, the factors and mechanisms driving their proliferation are unclear. We conducted a multi-year survey around the Caribbean island of Curaçao, which revealed highest BCM abundance on sheltered reefs close to urbanised areas. Reefs with high BCM abundance were also characterised by high benthic cover of macroalgae and low cover of corals. Nutrient concentrations in the water-column were consistently low, but markedly increased just above substrata (both sandy and hard) covered with BCMs. This was true for sites with both high and low BCM coverage, suggesting that BCM growth is stimulated by a localised, sub-strate-linked release of nutrients from the microbial degradation of organic matter. This hypothesis was supported by a higher organic content in sediments on reefs with high BCM coverage, and by an in situ experiment which showed that BCMs grew within days on sediments enriched with organic matter (Spirulina). We propose that nutrient runoff from urban-ised areas stimulates phototrophic blooms and enhances organic matter concentrations on the reef. This organic matter is transported by currents and settles on the seabed at sites with low hydrodynamics. Subsequently, nutrients released from the organic matter degradation fuel the growth of BCMs. Improved management of nutrients generated on land should lower organic loading of sediments and other benthos (e.g. turf and macroalgae) to reduce BCM proliferation on coral reefs.
ISSN: 1932-6203

hal-01159626
https://hal-univ-perp.archives-ouvertes.fr/hal-01159626
https://hal-univ-perp.archives-ouvertes.fr/hal-01159626/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01159626/file/journal.pone.0125445.pdf
DOI : 10.1371/journal.pone.0125445

Éditeur(s) : HAL CCSD American Society for Investigative Pathology
Résumé : International audience
Recent studies suggest that psoriasis may be more severe in patients with nonalcoholic fatty liver disease, particularly in those with the inflammatory stage of steatohepatitis [nonalcoholic steatohepatitis (NASH)]. Herein, we investigated the impact of diet-induced steatohepatitis on the severity of imiquimod-induced psoriasiform dermatitis. Mice fed with a high-fat diet developed steatohepatitis reminiscent of human NASH with ballooning hepatocytes and significant liver fibrosis. Mice with steatohepatitis also displayed moderate cutaneous inflammation characterized by erythema, dermalinfiltrates of CD45(+) leukocytes, and a local production of IL-17A. Moreover, steatohepatitis was associated with an epidermal activation of caspase-1 and cutaneous overexpression of IL-1 beta. Imiquimod-induced psoriasiform dermatitis was exacerbated in mice with steatohepatitis as compared to animals fed with a standard diet. Scale formation and acanthosis were aggravated, in correlation with increased IL-17A and IL-22 expression in inflamed skins. Finally, intradermal injection of IL-17A in standard diet-fed mice recapitulated the cutaneous pathology of mice with steatohepatitis. The results show that high-fat diet induced steatohepatitis aggravates the inflammation in psoriasiform dermatitis, via the cutaneous production of IL-17A. In agreement with clinical data, this description of a novel extrahepatic manifestation of NASH should sensitize dermatologists to the screening and the management of fatty liver in psoriatic patients.
ISSN: 0002-9440

hal-01390977
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390977
DOI : 10.1016/j.ajpath.2016.05.012
PUBMED : 27423696

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : La perspective d’un classement en « cœur de parc » des îlets Pigeon, haut lieu de la plongée sous-marine, relance les débats autour de la place des sports de nature dans le Parc national de la Guadeloupe. Faut-il craindre une interdiction de la plongée sous-marine en cœur de parc, comme ce fut le cas pour le canyoning, suite au conflit environnemental entourant cette pratique ? La réglementation est-elle toujours de mise, alors que la loi sur les parcs de 2006 exhorte les parcs à s’engager dans des démarches partenariales, afin de bâtir un projet de territoire reposant sur les principes du développement durable et de solidarité écologique entre le cœur de parc et ses espaces environnants ? Parallèlement, si le Parc doit passer d’une gestion de crises, souvent hésitante et parfois arbitrale, à une gestion concertée, de quel potentiel de coopération dispose-t-il pour dépasser des situations de conflits potentiels comme celle des îlets Pigeon ? Existe-t-il un effet d’apprentissage du conflit du canyoning capable de modeler ce potentiel de coopération ?
The probability that the Pigeon Islands, a Mecca for diving, will be classified as a protected “heart of park”, reopens the debate about outdoor sports in the National Park of Guadeloupe. Should we be worried about the prohibition of diving in this “heart of park”, as has happened in the case of canyoning, following an environmental conflict around this practice? Are regulations always acceptable, when at the same time the law on the national parks of 2006 exhorts the parks to make a commitment to participatory initiatives, and to create projects based on the principles of sustainable development and ecological solidarity between the heart of park and its surrounding spaces? At the same time, if the Park has to develop from a crisis management style, with hesitating and arbitrary decisions, to a more cooperative management style, what potential is there to use cooperation to overcome possible conflict situations such as the Pigeon Islands? Are there lessons to be learned from the conflict surrounding the canyoning, which would help model the process and benefits of cooperation?
Guadeloupe

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.3608
http://journals.openedition.org/etudescaribeennes/3608

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Marine Protected Areas (MPAs), if well designed and managed, can produce conservation benefits to fish assemblages within no-take zones and fishery benefits in neighboring areas through ‘spillover’. However, although plenty of studies have provided evidence of the benefits produced within MPA boundaries, overall benefits to local fisheries, especially via spillover, seem to be still unclear. Because of the lost fishing grounds following an MPA establishment, local fishermen usually oppose MPAs. There is, therefore, the urgent need for a better understanding of the mechanism(s) through which MPAs can export fishable fish biomass towards adjacent fished areas, a process that could counterbalance the loss of fishing grounds. Here we review the literature on spillover for refining the terminology, detailing the underlying mechanisms and identifying both the existing and needed methodological approaches to measure spillover. Operationally, two types of spillover should be considered: ecological spillover (i.e. the net export of juvenile, subadult and adult biomass from MPAs outwards driven by density-dependent processes) and the fishery spillover (i.e. the proportion of this biomass that can be fished, taking into account regulations and accessibility). Underwater visual census and tagging/tracking may allow getting evidence of ecological spillover, while experimental catch data are essential to assess and monitor fishery spillover, which is the main component of MPAs that can provide direct benefit to local fisheries.
ISSN: 1617-1381

hal-01325478
https://hal-univ-perp.archives-ouvertes.fr/hal-01325478
DOI : 10.1016/j.jnc.2016.04.004

Éditeur(s) : HAL CCSD American Medical Association (AMA)
Résumé : International audience
IMPORTANCE Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome. OBJECTIVE To determine whether empirical micafungin reduces invasive fungal infection (IFI)-free survival at day 28. DESIGN, SETTING, AND PARTICIPANTS Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill patients with ICU-acquired sepsis, multiple Candida colonization, multiple organ failure, exposed to broad-spectrum antibacterial agents, and enrolled between July 2012 and February 2015 in 19 French ICUs. INTERVENTIONS Empirical treatment with micafungin (100mg, once daily, for 14 days) (n = 131) vs placebo (n = 129). MAIN OUTCOMES AND MEASURES The primary end pointwas survival without proven IFI 28 days after randomization. Key secondary end points included new proven fungal infections, survival at day 28 and day 90, organ failure, serum (1-3)-beta-D-glucan level evolution, and incidence of ventilator-associated bacterial pneumonia. RESULTS Among 260 patients (mean age 63 years; 91 [35%] women), 251 (128, micafungin group; 123, placebo group) were included in the modified intent-to-treat analysis. Median values were 8 for Sequential Organ Failure Assessment (SOFA) score, 3 for number of Candida-colonized sites, and 99 pg/mL for level of (1-3)-beta-D-glucan. On day 28, there were 82 (68%) patients in the micafungin group vs 79 (60.2%) in the placebo group who were alive and IFI free (hazard ratio [HR], 1.35 [95% CI, 0.87-2.08]). Results were similar among patients with a (1-3)-beta-D-glucan level of greater than 80 pg/mL (n = 175; HR, 1.41 [95% CI, 0.85-2.33]). Day-28 IFI-free survival in patients with a high SOFA score (> 8) was not significantly different when compared between the micafungin vs placebo groups (HR, 1.69 [95% CI, 0.96-2.94]). Use of empirical micafungin decreased the rate of new invasive fungal infection in 4 of 128 patients (3%) in the micafungin group vs placebo (15/123 patients [12%]) (P =.008). CONCLUSIONS AND RELEVANCE Among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure, empirical treatment with micafungin, compared with placebo, did not increase fungal infection-free survival at day 28.
ISSN: 0098-7484

hal-01405822
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01405822
DOI : 10.1001/jama.2016.14655
PUBMED : 27706483

Éditeur(s) : HAL CCSD Springer Verlag/EDP Sciences
Résumé : International audience
Chlorophyll meters such as the SPAD-502 offer a simple, inexpensive and rapid method to estimate foliar chlorophyll content. However, values provided by SPAD-502 are unitless and require empirical calibrations between SPAD units and extracted chlorophyll values. * Leaves of 13 tree species from the tropical rain forest in French Guiana were sampled to select the most appropriate calibration model among the often-used linear, polynomial and exponential models, in addition to a novel homographic model that has a natural asymptote.* The homographic model best accurately predicted total chlorophyll content (μg cm−2) from SPAD units (R2 = 0.89). Interspecific differences in the homographic model parameters explain less than 7% of the variation in chlorophyll content in our data set. * The utility of the general homographic model for a variety of research and management applications clearly outweighs the slight loss of model accuracy due to the abandon of the species' effect.
ISSN: 1286-4560

Droits : info:eu-repo/semantics/OpenAccess
hal-00883628
https://hal.archives-ouvertes.fr/hal-00883628
https://hal.archives-ouvertes.fr/hal-00883628/document
https://hal.archives-ouvertes.fr/hal-00883628/file/hal-00883628.pdf
DOI : 10.1051/forest/2010020

Éditeur(s) : Wiley-blackwell
Résumé : Managing fisheries resources to maintain healthy ecosystems is one of the main goals of the ecosystem approach to fisheries (EAF). While a number of international treaties call for the implementation of EAF, there are still gaps in the underlying methodology. One aspect that has received substantial scientific attention recently is fisheries-induced evolution (FIE). Increasing evidence indicates that intensive fishing has the potential to exert strong directional selection on life-history traits, behaviour, physiology, and morphology of exploited fish. Of particular concern is that reversing evolutionary responses to fishing can be much more difficult than reversing demographic or phenotypically plastic responses. Furthermore, like climate change, multiple agents cause FIE, with effects accumulating over time. Consequently, FIE may alter the utility derived from fish stocks, which in turn can modify the monetary value living aquatic resources provide to society. Quantifying and predicting the evolutionary effects of fishing is therefore important for both ecological and economic reasons. An important reason this is not happening is the lack of an appropriate assessment framework. We therefore describe the evolutionary impact assessment (EvoIA) as a structured approach for assessing the evolutionary consequences of fishing and evaluating the predicted evolutionary outcomes of alternative management options. EvoIA can contribute to EAF by clarifying how evolution may alter stock properties and ecological relations, support the precautionary approach to fisheries management by addressing a previously overlooked source of uncertainty and risk, and thus contribute to sustainable fisheries.
Fish And Fisheries (1467-2960) (Wiley-blackwell), 2014-03 , Vol. 15 , N. 1 , P. 65-96

Droits : 2012 John Wiley & Sons Ltd
http://archimer.ifremer.fr/doc/00124/23522/21409.pdf
DOI:10.1111/faf.12007
http://archimer.ifremer.fr/doc/00124/23522/