Éditeur(s) : HAL CCSD
Résumé : International audience
The strength of the lithospheric mantle controls the mode of lithosphere deformation: the presence or absence ofa high strength brittle mantle respectively leads to localized or distributed rifting. However, first order geophysicaldata question the existence of such a brittle mantle. Here we use 2-D finite-element large strain modelling toquantify the impact of a ductile localizing mantle – instead of brittle – in triggering continental rifting. As a novelty,the mantle rheology considers the effect of grain boundary sliding during strain-induced grain size reduction,which may promote a significant strength drop and subsequent strain localization at low mantle temperature (<700-800°C). Our results reveal that such ductile localizing mantle implies varying modes of continental rifting thatmainly depend on both the amount of weakening in the ductile mantle and the strength of the lower ductile crust. Amedium to strong lower crust implies coupling between the upper crust and ductile localizing mantle, yielding tonarrow continental rifting. In contrast, a weak lower crust implies decoupling between the upper crust and ductilelocalizing mantle, giving rise to a switch from distributed faulting at incipient strain to localized faulting at largestrain. Ductile strain localization in the lithospheric mantle is therefore sufficient to trigger continental rifting,although a critical amount of weakening is required. Such ductile localizing mantle provides a relevant geologicaland mechanical alternative to the brittle mantle. It moreover provides a wider variety of modes of upper crustalfaulting that are commonly observed in nature.
EGU General Assembly 2014
Vienne, Austria

insu-01565161
https://hal-insu.archives-ouvertes.fr/insu-01565161

Éditeur(s) : HAL CCSD
Résumé : Dans une première partie est proposé un curriculum vitae commenté. Y est présenté notre cheminement, de la fatigue des muscles ventilatoires, thème développé en thèse puis approfondi dans un post-doctorat jusqu'à la régulation de l'appétit par l'activité physique d'une part, et la prise en charge par l'activité physique de populations à risque cardiovasculaire élevé d'autre part, thématiques de travail qui nous animent actuellement pour la partie fondamentale. Il s'agit de montrer les articulations et les cohérences, de faire émerger des régularités – dans les défauts et les qualités -, mais aussi de justifier les allers-retours entre des préoccupations plutôt fondamentales ou méthodologiques, et les interventions sur le terrain. Dans une deuxième partie sont développés l'approche théorique et des arguments permettant d'appréhender les comportements d'activité physique chez l'humain comme une cause possible de maladie cardiovasculaire ou métabolique, ce qui nécessite quelques réflexions sur la notion de facteur de risque, et sur les places respectives de l'épidémiologie et du paradigme expérimental dans l'élaboration de la connaissance dans ce champ. Les comportements sédentaires y sont présentés comme un stress pour l'organisme dans une perspective philogénétique, et nous présentons la promotion de l'activité physique comme une indispensable dimension des actions en santé publique relatives aux maladies métaboliques et cardiovasculaires, à leur prévention et à leur prise en charge.Enfin, dans une dernière partie sont présentés des travaux de terrain prévus ou terminés, sélectionnés parmi d'autres études et témoignant de notre implication en Guadeloupe et Martinique à promouvoir l'activité physique. Nous rendons compte d'éléments caractérisant des besoins d'intervention en activité physique dans des populations adolescentes et étudiantes en Guadeloupe, mais nous mettons aussi en évidence la spécificité du groupe des Guadeloupéens originaires d'Inde vis-à-vis de ces comportements d'activité physique. Nous rapportons également la mise en place et certaines observations issues d'un programme de promotion des activités physiques nautiques à destination d'adultes porteurs de maladie chronique. Enfin, nous traçons les grandes lignes d'un projet de réentrainement à l'effort de personnes à risque cardiovasculaire modéré ou élevé qui va nous mobiliser dans les mois à venir.
https://hal.archives-ouvertes.fr/tel-01487688

Droits : info:eu-repo/semantics/OpenAccess
tel-01487688
https://hal.archives-ouvertes.fr/tel-01487688
https://hal.archives-ouvertes.fr/tel-01487688/document
https://hal.archives-ouvertes.fr/tel-01487688/file/HDR_S_Antoine.pdf

Éditeur(s) : GREAL : Groupe de Recherches en Esthétiques, Arts et Littératures
Extrait de : "L'oeuvre de Joseph Zobel : portées, héritages et modernité" : colloque international, du 14 au 16 octobre 2015. Université des Antilles
Description : Marjory ADENET-LOUVET, doctorante en littérature comparée à l'Université des Antilles, propose une réflexion sur la mise en fiction du livre dans deux oeuvres de Joseph Zobel : "La Rue Case-Nègres" et "le Syllabaire". Elle rappelle que le savoir était de fait la propriété exclusive du colon jusqu'en 1848, date à partir de laquelle se créait une nouvelle mythologie de l'écrit. Grâce à un certain discours de l'école, le livre apparaît comme un média salvateur et pourvoyeur de promotion de social. L'apprentissage de l'écrit transforme alors en profondeur la société antillaise en créant un large champ de nouveaux possibles pour des populations jusque-là exclues de l'histoire et de toute participation sociale. Tel est le point de départ de l'analyse proposée de la mise en fiction dans les deux ouvrages étudiés.
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V15345
V15345

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : This paper examines the changing fortunes of Durban as a tourist city from the apartheid to the post apartheid eras. Durban has long earned its prime position as one of South Africa’s most popular year‑round tourist destination. In keeping with the dictates of apartheid, the city catered largely for the needs of the white minority, while that of the black majority was largely ignored. With political changes and shifts in both the international and domestic markets, an effort had to be made to reposition tourism in the city. In order to successfully promote its tourism opportunities, Durban attempted to enhance its image and appeal by promoting its sports, convention and cultural attractions. The democratic transition of the 1990s provided many challenges, the most enduring of which was the need to cater for the emerging black tourist market. There was also an urgency to address problems of crime and grime, disparities in the distribution of labour market opportunities, especially in terms of race and gender within the tourism sector. A serious threat to tourism in Durban is unemployment and alienation of the majority of African people from the industry.
Ce document examine l'évolution des dynamiques touristiques de la ville de Durban dans un contexte post-apartheided. La ville de Durban s’est imposée comme l'une des destinations touristiques les plus populaires d’'Afrique du Sud. En accord avec les diktats de l'apartheid, pour satisfaire les souhaits d’une minorité blanche, l’organisation de la ville avait ignoré les besoin de la majorité noire. Aujourd’hui la ville de Durban se repositionne sur l’échiquier touristique, portée par les changements politiques intérieurs et les opportunités des marchés touristiques internationaux et nationaux. Afin de se positionner avec succèssur ce marché, la ville de Durban renforce son image autour de la promotion son front de mer, des sports nautiques, du tourisme de congrés, et des animations culturelles. La transition démocratique des années 1990 a fourni de nombreux défis et oppportunités dans la première sur le plan touristique fut de se positionner sur le nouveau marché touristique noir. Cal passe aussi par les urgence à résoudre sur le plan de la criminalité, de l’hygiène et de la résorption des disparités sur le marché du travail, en particulier en termes de race et de l'égalité des sexes dans le secteur du tourisme. Les plus sérieuses limites pour le tourisme à Durban sont le chômage et la marginalisation de la majorité des African people.
Afrique du Sud
Durban

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.1192
http://journals.openedition.org/etudescaribeennes/1192

Éditeur(s) : Digital Library of the Caribbean Digital Library of the Caribbean ( Miami, Florida )

http://ufdc.ufl.edu/UF00094131/00003

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
We herein focus on understanding what controls the detachment and migration of oceanic crustal slices along subduction zones. We provide evidence for the coeval Middle to Late Cretaceous exhumation of oceanic blueschists in the same Neotethyan subduction zone, across more than 3000 km, from depths around 30-40 km, over a short time interval (similar to 25 Ma) compared to the duration of subduction (>100 Ma). We stress the importance of such a geodynamic process and suggest that this exhumation was promoted by a regional-scale change in the long-term interplate mechanical coupling. On the basis of geological and geophysical evidence, we propose that the upward migration of oceanic fragments in subduction zones is normally inhibited and only occurs discontinuously, as the subduction channel opens up in response to a major change in plate geodynamics, slab geometry and dynamics, mantle wedge and slab hydration, or a combination of these.
ISSN: 1525-2027

hal-00420898
https://hal.archives-ouvertes.fr/hal-00420898
DOI : 10.1029/2009GC002428

Éditeur(s) : HAL CCSD American Society for Microbiology
Résumé : International audience
Under physiological conditions, the liver sinusoidal endothelial cells (LSECs) mediate hepatic immune tolerance toward self or foreign antigens through constitutive expression of anti-inflammatory mediators. However, upon viral infection or Toll-like receptor 2 (TLR2) activation, LSECs can achieve proinflammatory functions, but their role in hepatic inflammation during acute viral hepatitis is unknown. Using the highly virulent mouse hepatitis virus type 3 (MHV3) and the attenuated variants 51.6-MHV3 and YAC-MHV3, exhibiting lower tropism for LSECs, we investigated in vivo and in vitro the consequence of LSEC infection on their proinflammatory profiles and the aggravation of acute hepatitis process. In vivo infection with virulent MHV3, in comparison to attenuated strains, resulted in fulminant hepatitis associated with higher hepatic viral load, tissue necrosis, and levels of inflammatory mediators and earlier recruitment of inflammatory cells. Such hepatic inflammatory disorders correlated with disturbed production of interleukin-10 (IL-10) and vascular factors by LSECs. We next showed in vitro that infection of LSECs by the virulent MHV3 strain altered their production of anti-inflammatory cytokines and promoted higher release of proinflammatory and procoagulant factors and earlier cell damage than infection by attenuated strains. This higher replication and proinflammatory activation in LSECs by the virulent MHV3 strain was associated with a specific activation of TLR2 signaling by the virus. We provide evidence that TLR2 activation of LSCEs by MHV3 is an aggravating factor of hepatic inflammation and correlates with the severity of hepatitis. Taken together, these results indicate that preservation of the immunotolerant properties of LSECs during acute viral hepatitis is imperative in order to limit hepatic inflammation and damage. IMPORTANCE Viral hepatitis B and C infections are serious health problems affecting over 350 million and 170 million people worldwide, respectively. It has been suggested that a balance between protection and liver damage mediated by the host's immune response during the acute phase of infection would be determinant in hepatitis outcome. Thus, it appears crucial to identify the factors that predispose in exacerbating liver inflammation to limit hepatocyte injury. Liver sinusoidal endothelial cells (LSECs) can express both anti- and proinflammatory functions, but their role in acute viral hepatitis has never been investigated. Using mouse hepatitis virus (MHV) infections as animal models of viral hepatitis, we report for the first time that in vitro and in vivo infection of LSECs by the pathogenic MHV3 serotype leads to a reversion of their intrinsic anti-inflammatory phenotype toward a proinflammatory profile as well to as disorders in vascular factors, correlating with the severity of hepatitis. These results highlight a new virus-promoted mechanism of exacerbation of liver inflammatory response during acute hepatitis.
ISSN: 0022-538X

hal-01390974
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390974
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390974/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390974/file/Mouse%20Hepatitis%20Virus%20Infection_accepted.pdf
DOI : 10.1128/JVI.01069-16

Éditeur(s) : HAL CCSD
Résumé : Staphylococcus aureus is an opportunistic pathogen of humans and warm-blooded animals. It is foundin healthy carriage and can cause a wide range of infections in its hosts. The epithelial surface is theprincipal site of staphylococcal infection. The pathogens have evolved sophisticated mechanisms tohijack the main function of the host cells, thus promoting their invasion and colonization. Amongstthese effects are, alteration of host cell apoptosis, promotion of cell proliferation or conversely,inhibition of cell growth. Using human cervix cancer HeLa and mammary gland bovine MAC-Tepithelial cells, we studied the cytopathic effect of S. aureus and its ability to affect host cell cycle.Using microscopic examination, we found that S. aureus induced the cytopathic effect resulting in theenlargement of the host cells 72 hours post infection. Our experiments showed that the proliferationrate of the epithelial cells was slowed down in S. aureus-infected culture. Three different S. aureusstrains from human and animal origins were used and showed similar effect on both human and bovinecells. Microscopic analysis of DAPI-stained cells revealed huge decrease of mitotic indexes in infectedHeLa and Mac-T cells, synchronized by Double Thymidine Block. Using flow cytometry analysis, wefound that S. aureus induces G2/M phase delay in synchronous HeLa cells. By Western blot analysis,we showed that the G2/M phase delay was associated with accumulation of inactive phosphorylatedcyclin-dependent kinase Cdk1/cdc2, a key inducer of mitosis entry, and dephosphorylation of corehistone H3, an important component of the epigenetic landscape.These results suggest that the delay in G2/M phase transition of the infected epithelial cells may beone of the mechanisms employed by S. aureus to survive and to propagate inside the host. A fullcomprehension of the mechanisms associated to S. aureus-host cell interactions will undoubtedly helpto discover novel targets to treat staphylococcal infections.
EMBO
Villars sur Ollon, Switzerland

hal-01454214
https://hal.archives-ouvertes.fr/hal-01454214
PRODINRA : 171657

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Few studies have considered using environmental amenities to explain social health inequalities.Nevertheless, Green spaces that promote good health may have an effect on socioeconomic health inequalities. In developed countries, there is considerable evidence that green spaces have a beneficial effect on the health of urban populations and recent studies suggest they can have a positive effect on pregnancy outcomes. To investigate the relationship between green spaces and the spatial distribution of infant mortality taking account neighborhood deprivation levels. METHODS: The study took place in Lyon metropolitan area, France. All infant deaths that occurred between 2000 and 2009 were geocoded at census block level. Each census block was assigned greenness and socioeconomic deprivation levels. The spatial--scan statistic was used to identify high risk cluster of infant mortality according to these neighborhood characteristics. RESULTS: The spatial distribution of infant mortality was not random with a high risk cluster in the south east of the Lyon metropolitan area (p<0.003). This cluster disappeared (p=0.12) after adjustment for greenness level and socioeconomic deprivation, suggesting that these factors explain part of the spatial distribution of infant mortality. These results are discussed using a conceptual framework with 3 hypothetical pathways by which green spaces may have a beneficial effect on adverse pregnancy outcomes: (i) a psychological pathway, (ii) a physiological disruption process and (iii) an environmental pathway. CONCLUSIONS: These results add some evidence to the hypothesis that there is a relationship between access to green spaces and pregnancy outcomes but further research is required to confirm this.
BMC Pregnancy and Childbirth

hal-00876083
https://hal.archives-ouvertes.fr/hal-00876083
https://hal.archives-ouvertes.fr/hal-00876083/document
DOI : 10.1186/1471-2393-13-191

Éditeur(s) : HAL CCSD American Public Health Association
Résumé : International audience
Sickle cell disease (SCD) is a significant problem in the Caribbean, where many individuals have African and Asian forebears. However, reliable prevalence data and specific health care programs for SCD are often missing in this region. Closer collaboration between Caribbean territories initiated in 2006 to set up strategies to promote better equity in the health care system for SCD patients led to the formation of CAREST: the Caribbean Network of Researchers on Sickle Cell Disease and Thalassemia. We present the effectiveness of collaborations established by CAREST to promote SCD newborn screening programs and early childhood care, to facilitate health worker training and approaches for prevention and treatment of SCD complications, and to carry out inter-Caribbean research studies.
ISSN: 0090-0036

hal-01668331
https://hal.univ-antilles.fr/hal-01668331
DOI : 10.2105/AJPH.2016.303078

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A set of four reactive flow-through experiments at temperature T = 100 degrees C and total pressure P=12 MPa was performed in limestone reservoir samples. By using various ranging from 0.7 to 10 MPa, these experiments mimic mass transfers occurring (1) near the injection well, where the brine is almost saturated with CO2 (i.e. P-CO2 approximate to P), and (2) at increasing distances from the injection well, where the fluid displays lower values and higher divalent cation concentrations due rock dissolution along the fluid pathway. Results for P-CO2 = 10 MPa show non-uniform dissolution features associated with transport-controlled mass transfer, while reaction-controlled uniform dissolution is observed for P-CO2 = 2.5 MPa. The experiment with P-CO2 = 6 MPa allows investigating in detail the transition from transport-to reaction-controlled dissolution. Conversely, the experiment reproducing conditions far from the injection well (P-CO2 = 0.7 MPa), shows a decrease of porosity triggered by the precipitation of Mg-rich calcite. For all the dissolution experiments, the time-resolved porosity phi(t) can be modeled by a simple non-linear equation including parameters that characterise the dissolution regime triggered by the reactivity of the inlet fluid (measured by the Damkohler number, Da). Furthermore, all dissolution experiments display power scaling between permeability (k) and porosity (phi) with distinctly different scaling exponents characterising the reactivity of the fluid percolating the sample, independently from the decrease with time of the reactive surface area. It is shown also that dissolution at moderate positive values of Da seems the most efficient to increase permeability and promote a rapid spreading of the reaction front, while inducing minimal modification of the porosity in the vicinity of the CO2 injection well. These results can be used to parameterize the k-phi function for modeling the earliest dissolution processes occurring in the vicinity of the reaction front.
ISSN: 0009-2541

hal-00445277
https://hal.archives-ouvertes.fr/hal-00445277
DOI : 10.1016/j.chemgeo.2009.03.028

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Few studies have considered using environmental amenities to explain social health inequalities.Nevertheless, Green spaces that promote good health may have an effect on socioeconomic health inequalities. In developed countries, there is considerable evidence that green spaces have a beneficial effect on the health of urban populations and recent studies suggest they can have a positive effect on pregnancy outcomes. To investigate the relationship between green spaces and the spatial distribution of infant mortality taking account neighborhood deprivation levels. METHODS: The study took place in Lyon metropolitan area, France. All infant deaths that occurred between 2000 and 2009 were geocoded at census block level. Each census block was assigned greenness and socioeconomic deprivation levels. The spatial--scan statistic was used to identify high risk cluster of infant mortality according to these neighborhood characteristics. RESULTS: The spatial distribution of infant mortality was not random with a high risk cluster in the south east of the Lyon metropolitan area (p<0.003). This cluster disappeared (p=0.12) after adjustment for greenness level and socioeconomic deprivation, suggesting that these factors explain part of the spatial distribution of infant mortality. These results are discussed using a conceptual framework with 3 hypothetical pathways by which green spaces may have a beneficial effect on adverse pregnancy outcomes: (i) a psychological pathway, (ii) a physiological disruption process and (iii) an environmental pathway. CONCLUSIONS: These results add some evidence to the hypothesis that there is a relationship between access to green spaces and pregnancy outcomes but further research is required to confirm this.
ISSN: 1471-2393

inserm-00878362
http://www.hal.inserm.fr/inserm-00878362
http://www.hal.inserm.fr/inserm-00878362/document
http://www.hal.inserm.fr/inserm-00878362/file/1471-2393-13-191.pdf
DOI : 10.1186/1471-2393-13-191

Éditeur(s) : HAL CCSD
Résumé : International audience
Primary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase. The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy. Many reports suggest that the mitogen-activated protein kinase (MAPK) ERK1/2 can support hepatocyte proliferation in vitro and in vivo and the MEK/ERK cascade acts as an essential element in hepatocyte responses induced by the EGF. Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma. Whereas the strict specificity of action of ERK1 and ERK2 is still debated, the MAPKs may have specific biological functions under certain contexts and according to the differentiation status of the cells, notably hepatocytes. In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells. The possible specificity of ERK1 and ERK2 in normal and transformed hepatocyte will be discussed in regard to other differentiated and undifferentiated cellular models.
International Journal of Hepatology

Droits : info:eu-repo/semantics/OpenAccess
hal-00875664
https://hal.archives-ouvertes.fr/hal-00875664
https://hal.archives-ouvertes.fr/hal-00875664/document
https://hal.archives-ouvertes.fr/hal-00875664/file/TheMAPKMEK12-accepted.pdf
DOI : 10.1155/2012/328372

Éditeur(s) : HAL CCSD
Résumé : In Taiwan , the subduction of the Chinese continental margin under the Luzon arc results in the progressive growth of an active orogenic wedge. It is one of the best places to study the complex relationships that occurs between the tectonic processes controlling deformation (plate rheology and kinematics, metamorphism and magmatism) and surface processes (erosion and sedimentation). In order to study the kinematics of the present day convergence of Philippine Sea plate to the Asian continent around Taiwan, we perform 2D and 3D sandbox modeling and we analyzed the models with PIV (Particle Image Velocimetry) software. In 2D experiments, a model Coulomb wedge is submitted to erosion and sedimentation under topography and flux steady state conditions. The 3D experiments are mainly used to study the escape tectonics occurring in the middle west and southwest Taiwan. A wedge shaped indenter and a basement relief were used to simulate the mechanical plate boundary between Philippine Sea plate and Eurasia plate and the basement topography to the west of Taiwan respectively. We examine the exhumation patterns, the mode of fault propagation and displacement patterns by strain partitioning of vertical vs. horizontal displacement and convergent parallel vs. orogen parallel components. The preliminary conclusions are: 1. The interactions between tectonics, erosion and sedimentation control geometry and kinematics of the doubly vergent transpressional orogen. 2. Exhumation processes are controlled by the balance between erosion, frontal accretion and underplating in different structural domains of the wedge. 3. Retrowedge erosion favorites backfolding and backthrusting, induces flower structures and fan shaped cleavage distribution. 4. Sedimentation promotes underplating and out-of sequences thrusting. 5. Continental subduction or subduction of topographic highs will enhance underthrusting/underplating, thick-skin tectonics and inversion of sedimentary basin.
Bolletino di Geofisica teorica ed applicata

hal-00411133
https://hal.archives-ouvertes.fr/hal-00411133

Éditeur(s) : HAL CCSD Taylor & Francis
Résumé : International audience
The retroviral genome consists of an intron-containing transcript that has essential cytoplasmic functions in the infected cell. This viral transcript can escape splicing, circumvent the nuclear checkpoint mechanisms and be transported to the cytoplasm by hijacking the host machinery. Once in the cytoplasm, viral unspliced RNA acts as mRNA to be translated and as genomic RNA to be packaged into nascent viruses. The murine leukemia virus (MLV) is among the first retroviruses discovered and is classified as simple Retroviridae due to its minimal encoding capacity. The oncogenic and transduction abilities of MLV are extensively studied, whereas surprisingly the crucial step of its nuclear export has remained unsolved until 2014. Recent work has revealed the recruitment by MLV of the cellular NXF1/Tap-dependent pathway for export. Unconventionally, MLV uses of Tap to export both spliced and unspliced viral RNAs. Unlike other retroviruses, MLV does not harbor a unique RNA signal for export. Indeed, multiple sequences throughout the MLV genome appear to promote export of the unspliced MLV RNA. We review here the current understanding of the export mechanism and highlight the determinants that influence MLV export. As the molecular mechanism of MLV export is elucidated, we will gain insight into the contribution of the export pathway to the cytoplasmic fate of the viral RNA
ISSN: 1547-6286

hal-01217990
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217990
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217990/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217990/file/Insights%20into%20the%20nuclear%20export%20of%20murine%20leukemia%20virus%20intron-containing%20RNA.pdf
DOI : 10.1080/15476286.2015.1065375

Éditeur(s) : Elsevier
Résumé : Beach sediment cementation (beachrock formation) is a sedimentary process that can transform significant sections of beaches into rock outcrops. This contribution reports the results of two questionnaire surveys (one focusing on foreign tourists and the other on local people) carried out in coastal resorts of the island of Lesbos (Greece), on the perceptions of beach users regarding the impacts of beachrocks on their recreational activities. The survey focusing on foreign tourists showed that the majority of the interviewees took notice of the formations and commented negatively on them. Although most of the interviewees did not consider beachrocks a significant safety risk, a considerable proportion of the sample stated that beachrocks influenced their beach ratings that they would prefer beachrock-free beaches and would be willing to contribute financially to preventative and protective measures. In contrast, the results of the survey focusing on local people, who are more familiar with the phenomenon, showed a high perception of beachrock-related risks and limited beachrock tolerance. In addition to the safety risks that the irregular, slippery, beachrock surfaces may pose to beach users, beachrocks may also degrade beach aesthetics. promote beach sediment erosion and decrease the beach carrying capacity. As beachrocks are a common attribute of tropical, subtropical and low-temperate beaches that are typically associated with major tourist destinations, and are likely to spread under global warming conditions, they may be considered as a significant threat to the coastal tourist industry. (c) 2008 Elsevier Ltd. All rights reserved.
Tourism Management (0261-5177) (Elsevier), 2009-08 , Vol. 30 , N. 4 , P. 544-552

Droits : 2009 Elsevier Ltd All rights reserved.
http://archimer.ifremer.fr/doc/2009/publication-6625.pdf
DOI:10.1016/j.tourman.2008.09.007
http://archimer.ifremer.fr/doc/00000/6625/

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
Although magmatism may occur during the earliest stages of continental rifting, its role in strain accommodation remains weakly constrained by largely 2-D studies. We analyze seismicity data from a 13 month, 39-station broadband seismic array to determine the role of magma intrusion on state-of-stress and strain localization, and their along-strike variations. Precise earthquake locations using cluster analyses and a new 3-D velocity model reveal lower crustal earthquakes beneath the central basins and along projections of steep border faults that degas CO2. Seismicity forms several disks interpreted as sills at 6-10 km below a monogenetic cone field. The sills overlie a lower crustal magma chamber that may feed eruptions at Oldoinyo Lengai volcano. After determining a new ML scaling relation, we determine a b-value of 0.87±0.03. Focal mechanisms for 65 earthquakes, and 13 from a catalogue prior to our array reveal an along-axis stress rotation of ∼60° in the magmatically active zone. New and prior mechanisms show predominantly normal slip along steep nodal planes, with extension directions ∼N90°E north and south of an active volcanic chain consistent with geodetic data, and ∼N150°E in the volcanic chain. The stress rotation facilitates strain transfer from border fault systems, the locus of early-stage deformation, to the zone of magma intrusion in the central rift. Our seismic, structural, and geochemistry results indicate that frequent lower crustal earthquakes are promoted by elevated pore pressures from volatile degassing along border faults, and hydraulic fracture around the margins of magma bodies. Results indicate that earthquakes are largely driven by stress state around inflating magma bodies.
ISSN: 1525-2027

hal-01667198
https://hal.archives-ouvertes.fr/hal-01667198
DOI : 10.1002/2017GC007027

Éditeur(s) : HAL CCSD
Résumé : International audience
The present study was conducted to assess the effects of Cd exposure on estrogen signaling in the zebrafish brain, as well as the potential protective role of Zn against Cd-induced toxicity. For this purpose, the effects on transcriptional activation of the estrogen receptors (ERs), aromatase B (Aro-B) protein expression and molecular expression of related genes were examined in vivo using wild-type and transgenic zebrafish embryos. For in vitro studies, an ER-negative glial cell line (U251MG) transfected with different zebrafish ER subtypes (ERα, ERβ1 and ERβ2) was also used. Embryos were exposed either to estradiol (E2), Cd, E2+Cd or E2+Cd+Zn for 72 h and cells were exposed to the same treatments for 30 h. Our results show that E2 treatment promoted the transcriptional activation of ERs and increased Aro-B expression, at both the protein and mRNA levels. Although exposure to Cd, does not affect the studied parameters when administered alone, it significantly abolished the E2-stimulated transcriptional response of the reporter gene for the three ER subtypes in U251-MG cells, and clearly inhibited the E2 induction of Aro-B in radial glial cells of zebrafish embryos. These inhibitory effects were accompanied by a significant downregulation of the expression of esr1, esr2a, esr2b and cyp19a1b genes compared to the E2-treated group used as a positive control. Zn administration during simultaneous exposure to E2 and Cd strongly stimulated zebrafish ERs transactivation and increased Aro-B protein expression, whereas mRNA levels of the three ERs as well as the cyp19a1b remained unchanged in comparison with Cd-treated embryos. In conclusion, our results clearly demonstrate that Cd acts as a potent anti-estrogen in vivo and in vitro, and that Cd-induced E2 antagonism can be reversed, at the protein level, by Zn supplement.
Journal of Applied Toxicology

Droits : info:eu-repo/semantics/OpenAccess
hal-01274217
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274217
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274217/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274217/file/Inhibitory%20effect%20of%20Cadmium%20on%20estrogen_accepted.pdf
DOI : 10.1002/jat.3285

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The emerging orbicular batfish (Platax orbicularis) aquaculture is the most important fish aquacultureindustry in French Polynesia. However, bacterial infections are causing severe mortality episodes.Therefore, there is an urgent need to find an effective management solution. Besides the supplyingdifficulty and high costs of veterinary drugs in French Polynesia, batfish aquaculture takes place close tothe coral reef, where use of synthetic persistent drugs should be restricted. Medicinal plants andbioactive algae are emerging as a cheaper and more sustainable alternative to chemical drugs. We havestudied the effect of local Polynesian plants and the local opportunistic algae Asparagopsis taxiformis onbatfish when orally administered. Weight gain and expression of two immune-related genes (lysozyme ge Lys G and transforming growth factor beta - TGF-b1) were studied to analyze immunostimulant activityof plants on P. orbicularis. Results showed that several plants increased Lys G and TGF-b1 expressionon orbicular batfish after 2 and 3 weeks of oral administration. A. taxiformis was the plant displaying themost promising results, promoting a weight gain of 24% after 3 weeks of oral administration andsignificantly increasing the relative amount of both Lys G and TGF-b1 transcripts in kidney and spleen ofP. orbicularis.
ISSN: 1050-4648

hal-01381334
https://hal-univ-perp.archives-ouvertes.fr/hal-01381334
DOI : 10.1016/j.fsi.2016.09.011

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Miocene (17-11 Ma) magmatic activity in the Kabylies emplaced K-rich (and minor medium-K) calc-alkaline plutonic and volcanic rocks in five zones, delineating a ∼450 km long EW trending strip located along the northern coast of Algeria, between Annaba and Algiers. Their most likely source is the Kabylian subcontinental lithospheric mantle previously metasomatized during the Paleogene subduction of the Tethys oceanic lithosphere. Our preferred tectono-magmatic model involves a Tethyan slab detachment combined with African mantle delamination and crustal stacking, leading to the superimposition of the African continental crust over the Kabylian metasomatized lithospheric mantle. At ca. 17 Ma, the asthenospheric upwelling arising from lithospheric delamination and Tethyan slab tear triggered the thermal erosion of the latter mantle, inducing its partial melting. The corresponding mafic medium-K calc-alkaline magmas interacted with the African basement units during their ascent, generating intermediate to felsic K-rich calc-alkaline melts that display a characteristic trace element and isotopic crustal signature. Later on, slab tears propagated eastward and westward, promoting slab rollback perpendicular to plate convergence and inducing the emplacement of magmatic rocks of decreasing ages from central-eastern Algeria towards Tunisia and Morocco.
ISSN: 0899-5362

hal-01467997
https://hal.archives-ouvertes.fr/hal-01467997
DOI : 10.1016/j.jafrearsci.2016.10.005