Éditeur(s) : HAL CCSD
Résumé : 1 p.
For groundwater issues (potential leakages in waste repository, aquifer management ...), the development of modeling techniques is far ahead of the actual knowledge of aquifers. This raises two fundamental issues: 1) which and how much data are necessary to make predictions accurate enough for aquifer management issues; 2) which models remain relevant to describe the heterogeneity and complexity of geological systems. The French observatory H+ was created in 2002 with the twofold motivation of acquiring a large database for validating models of heterogeneous aquifers, and of surveying groundwater quality evolution in the context of environmental changes. H+ is a network of 4 sites (Ploemeur, Brittany, France; HES Poitiers, France; Cadarache, France; Campos, Mallorca, Spain) with different geological, climatic, and economic contexts. All of them are characterized by a highly heterogeneous structure (fractured crystalline basement for Ploemeur, karstified and fractured limestone for Poitiers, Cadarache and Mallorca), which is far to be taken into account by basic models. Ploemeur is exploited as a tap-water plant for a medium-size coastal city (15,000 inhabitants) for 20 years. Each site is developed for long term investigation and monitoring. They involves a dense network of boreholes, detailed geological and geophysical surveys, periodic campaigns and/or permanent measurements of groundwater flow, water chemistry, geophysical signals (including ground motions), climatic parameter, etc. Several large-scale flow experiments are scheduled per year to investigate the aquifer structure with combined geophysical, hydrogeological, and geochemical instruments. All this information is recorded in a database that has been developed to improve the sustainability and quality of data, and to be used as a collaborative tool for both site researchers and modelers. This project lasts now for 5 years. It is a short time to collect the amount of information necessary to apprehend the complexity of aquifers; but it is already enough to obtain a few important scientific results about the very nature of the flow heterogeneity, the origin and residence time of water elements, the kinetic of geochemical processes, etc. We have also developed new methods to investigate aquifers (in-situ flow measurements, flow experiment designs, groundwater dating, versatile in-situ probes, etc.). This experience aiming at building up long term knowledge appears extremely useful to address critical issues related to groundwater aquifers: the structure and occurrence of productive aquifer in crystalline basement, the assessment of aquifer protection area in the context of highly heterogeneous flow, the biochemical reactivity processes, the long term evolution of both water quantity and quality in the context of significant environmental changes, for instance.
AGU, Fall Meeting 2008
San Francisco, United States

insu-00375980
https://hal-insu.archives-ouvertes.fr/insu-00375980

Éditeur(s) : PSIC 11 - 11th Pacific Science Inter-Congress : Pacific Countries and their Ocean: Facing Local and Global Changes / 2nd Symposium on French Research in the Pacific. March 2 - 6, 2009 Tahiti, French Polynesia
Résumé : Shrimp farming in New Caledonia relies on the culture of a domesticated strain of Litopenaeus stylirostris introduced from Mexico at a time when genetic principles were of little or no consideration. Since then, advances in agriculture and for some aquatic species of importance led caledonian shrimp farmers to reconsider the appropriateness of a genetic improvement strategy adapted to local biotechnical and economical constraints. This questioning involves many different and interrelated aspects: scientific and technologic (genetics, biosecurity, quarantine, ), economic and organizational (financing, diffusion of genetic improvement) and pedagogic (awareness of farmers). Local institutions, producers associations, research centre and sanitary services associated to carry on the test of a first improvement strategy based on the crossing of different strains of L. stylirostris. This conceptually simple approach aimed at eliminating inbreeding, the first genetic limitating factor of improvement in captive populations. A second domesticated strain was obtained from Hawaii by the caledonian farmers, imported through a quarantine under the control of the zoosanitary local authorities, and reproduced and tested as pure or crossbred stocks by Ifremer within the framework of an interdisciplinary research project financed by caledonian institutions. Present results for hybrids (better growth and survival in the absence of virus) demonstrate the validity of this approach. They also bring out the importance to simultaneously integrate in a development scheme, a breeding centre to maintain and reproduce disease free breeders. This strategy and organization, tested in New Caledonia, could possibly be of benefit to other small scale aquaculture activities in the pacific islands.
La filière crevetticole de Nouvelle-Calédonie s’est développée jusqu’à aujourd’hui à partir d’un stock domestiqué de Litopenaeus stylirostris introduit d’Amérique à une époque où les principes de base en génétique n’étaient pas ou peu appliqués en aquaculture. Les avancées récentes en agriculture et chez quelques espèces aquacoles d’importance mondiale ont conduit les acteurs de cette filière à se poser la question de la mise en place d’une stratégie d’amélioration génétique adaptée aux contraintes biotechniques et économiques locales. Cette réflexion comportait à la fois des aspects scientifiques et technologiques (génétique, biosécurité, quarantaine, conservatoire), économiques et organisationnels (coût de l’opération, modalité de diffusion du progrès attendu), pédagogiques (sensibilisation des fermiers). Des acteurs d’horizons différents (institutions locales, association de producteurs, centre de recherche, police zoosanitaire) se sont associés pour monter une opération de testage d’une première stratégie d’amélioration par croisement de souches de la même espèce. Cette stratégie conceptuellement simple visait l’élimination du premier facteur génétique de limitation des performances d’élevage d’une population captive, à savoir une consanguinité d’autant plus élevée que le nombre de géniteurs fondateurs était faible. Une seconde souche domestiquée a ainsi été acquise à Hawaii par les producteurs calédoniens, contrôlée en quarantaine par les services vétérinaires calédoniens en charge de la réglementation sanitaire, reproduite et testée pure et en croisement par l’Ifremer dans le cadre d’un projet de recherche pluridisciplinaire plus large financé par les institutions du Pays. Les résultats obtenus démontrent l’intérêt de la démarche (meilleure croissance, meilleure survie en l’absence de virus). Mais ils montrent aussi l’utilité d’intégrer simultanément dans le plan de développement de la filière une stratégie de conservation des souches parentales afin de disposer de géniteurs exempts de pathogènes. Cette stratégie et cette organisation testées en Nouvelle-Calédonie pourraient vraisemblablement être profitables à d’autres filières aquacoles modestes, en particulier dans les pays insulaires du Pacifique.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00198/30879/29247.pdf
http://archimer.ifremer.fr/doc/00198/30879/

Éditeur(s) : Université de la Rochelle
Résumé : In order to better understand the functioning of the Brouage intertidal mudflat (Marennes- Oléron Basin, France), its carbon-based trophic web has been modelled and analyzed. The foodweb building is based on the 4 step method of Inverse Analysis: 1) conceive an a priori model as the graph of compartments (nodes) between which exist fluxes of material (vertices). These vertices are the unknowns for the problem; 2) gather all the existing knowledge about the ecosystem and translate it into linear equations and inequalities involving the fluxes; 3) complete this set of data by common knowledge on the behaviour of the compartments and translate it into inequalities, 4) solve the obtained linear system under the parsimony principle to find a unique solution vector. The food-web analysis is based on. The first purpose of this work was a methodological one: inverse analysis method has been adapted to consider the seasonal and spatial variability of the temperate ecosystem: two seasons have been coupled in the computation and the area has been divided into three geographical zones along a cross-shore gradient. Hence, two types of physical exchanges are involved: the benthicpelagic ones and the advection ones. Statistical results can also be obtained by coupling Monte Carlo methods to Inverse Analysis. To study the obtained networks, new indices based on Markov Chains take delay into account in describing integrative transfers of material between compartments. This lets emerge the systems' properties that are not obvious at first sight and emphasizes the role of peculiar components. The second purpose was to apply such methods to the Brouage mudflat ecosystem in order to better understand its functioning. As the knowledge and methods evolve, various food webs were computed and analyzed with the help such indices and existing ones. Sensitivity analyses allow to point at the most crucial lacks of knowledge, which can orientate future field research. New data would improve the quality of the model in two ways: one the one hand, they would validate or invalidate the outcomes and on the other hand, they would give useful information to better constrain some of the black boxes and most uncertain fluxes, especially the advection and vertical flows. The main results of the study show a strongly seasonal system in which benthic and pelagic components are linked with intensity. The system is driven by its high local benthic primary production, but also depends on imports from the basin. Each of the 3 geographic zones has a peculiar functioning. The central zone corresponds to the classical description of European intertidal mudflats: very productive, it can feed the other regions. It is a production zone. The upper part is less productive but is fed by the middle one via the water column and can be exploited by shorebirds. It is a degradation zone (material is transformed for less qualitative). The lower part strongly depends on the basin imports for its functioning, as the cultivated bivalves act as a pump for pelagic material of which a great part is deposited under the cultivation structures (oyster racks or mussels "bouchots"). It is a transformation zone.
Un double objectif (méthodologique et appliqué) a été visé par une modélisation du réseau trophique de la vasière de Brouage (Bassin de Marennes Oléron, France) à l'aide de l'analyse inverse, et son étude à l'aide de l'analyse des réseaux. L'Analyse Inverse permet en effet de reconstruire l'ensemble du réseau à partir de données éparses, le problème du manque de données étant récurrent en Ecologie. Au plan méthodologique, l'analyse inverse a été adaptée à la prise en compte des caractères saisonnier et spatialement hétérogène d'un écosystème tempéré de zone intertidale : deux saisons ont ainsi été couplées et la vasière a été considérée le long d'un transect perpendiculaire au rivage et divisé en trois zones spatiales. Deux types de flux physiques interviennent donc : les flux verticaux de dépôt et remise en suspension, et les flux d'advection via la colonne d'eau. Des pistes d'amélioration et de nouvelles méthodes sont proposées. Un résultat sous forme statistique peut être obtenu en couplant l'utilisation de méthodes de Monte Carlo à l'analyse inverse pour la construction des réseaux trophiques. Les moyens d'étude des modèles ont été enrichis par la mise au point d'indices issus de la construction de chaînes de Markov et prenant en compte le caractère temporel des transferts de matière entre compartiments. Enfin, la transformation mathématique du modèle statique pour une étude dynamique de la stabilité de l'équilibre décrit est abordée. Plusieurs modèles ont été construits au cours de l'évolution des méthodes et de l'acquisition de connaissances sur le site. Des méthodes d'analyses existantes et d'autres mises au point dans le cadre de cet ouvrage ont été appliquées aux réseaux obtenus afin de faire émerger les propriétés du fonctionnement de la vasière et de souligner le rôle de certains compartiments. Des analyses de sensibilité permettent d'évaluer la robustesse des résultats et d'orienter les recherches futures en mettant en évidence les manques les plus cruciaux. Des données supplémentaires, notamment concernant les foraminifères benthiques, le zooplancton ou les mouvements verticaux du microphytobenthos permettront de fournir de meilleures contraintes et de valider (ou non) les résultats obtenus. Les principaux résultats montrent un système au fort caractère saisonnier dont les compartiments benthiques et pélagiques sont très liés. La production primaire benthique locale est un moteur important, mais qui ne suffirait pas à suppléer l'indispensable importation de matériel détritique. Le découpage de la vasière en trois zones fait apparaître les particularités de chacune. La zone centrale correspond à la description classique des « vasières intertidales européennes » : très productive, elle peut alimenter les autres régions. C'est une zone de production et d'exportation. La partie supérieure est moins productive et reçoit de la matière de la zone de milieu d'estran via la colonne d'eau. Sa production secondaire peut alors être exploitée par les limicoles, nombreux en hiver. C'est une zone de dégradation et d'exportation. Le bas d'estran dépend fortement des importations extérieures, « pompées » par les bivalves cultivés qui sont ainsi directement responsables d'une forte sédimentation sous les structures mytilicoles et ostréicoles. C'est une zone de transformation.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2005/these-2260.pdf
http://archimer.ifremer.fr/doc/00000/2260/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
CXCL-test is a method that uses the estrogen-dependent secretion of the natural endogenous chemokine CXCL12 to evaluate the estrogenic activity of molecules. CXCL12 chemokine is involved in the estrogen dependent proliferation of breast cancer cells. Its measure is an indicator of cell proliferation and is used as an alternative test to classical proliferation test. Here we aimed to optimize this test, first to increase the number of tested molecules in a single assay and then to decrease the number of intermediate steps. The optimized CXCL-test was finally used for the evaluation of the estrogenic potency of emerging chemical pollutants: the UV filter benzophenones (BPs). The effect of BPs on CXCL12 secretion was also validated by real time quantitative RT-PCR. The optimized CXCL-test allowed a fast and direct assessment of estrogenic potency of molecules. The estrogenic activities of benzophenones were characterized and divided in two groups. The first one contains weak estrogenic compounds (BP, BP1, BP2, BP3, 234BP and 2344′BP). The second one contains medium estrogenic compounds (4BP, 44′BP, BP8, THB).
ISSN: 0045-6535

hal-01477205
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477205
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477205/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477205/file/Rapid%20assessment%20of%20estrogenic%20compounds_accepted.pdf
DOI : 10.1016/j.chemosphere.2017.01.037

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : Contaminant migration in aquifers is one of the most debated issues in hydrogeology, as most experimental results display large deviations from the standard (asymptotic) Fickian dispersion theories. Multi-scale investigation and high-resolution sensors are required to determine the origin of non-asymptotic dispersion and validate models. For this, a set of multi-scale Single-Well Injection-Withdrawal (SWIW) tracer tests using a new dual-packer probe CoFIS, including a high resolution optical sensor TELog, are presented. When compared to standard techniques such as salinity measurements, it is shown that high-resolution optical measurements allow an improved characterization of the long-lasting non-asymptotic dispersion mechanisms.
ISSN: 1631-0713

hal-00445250
https://hal.archives-ouvertes.fr/hal-00445250
DOI : 10.1016/j.crte.2009.07.012

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : La dégradation de l’arganeraie fait toujours l’objet d’un débat acharné et éclairé d’un intérêt considérable de la part du public, de la presse et des milieux universitaires. Plusieurs études ont été faites pour trouver des explications et des solutions à ce phénomène. La majorité des résultats de ces travaux avancent les conséquences négatives de l’élevage caprin sur l’écosystème arganeraie dont la réduction de la surface est importante et a tendance à s’accélérer sans être compensée spontanément parce que la régénération naturelle de l’arganier ne s’effectue plus, et ceci en raison de plusieurs facteurs : urbanisation, sécheresses, cultures intensives et extensives sous les arbres en plaine et sur les plateaux (en irrigué et en bour), et surtout, selon ces études, le surpâturage par les éleveurs de chèvres. Dans cette étude, nous n’allons pas jauger le bien-fondé de ces résultats. Cependant, l’argument et l’hypothèse que nous choisissons sont que la conjugaison du surpâturage avec d’autres facteurs parmi lesquels, essentiellement, le succès récent de l’huile d’argane à l’étranger, va bousculer les savoirs écologiques liés au troupeau et à sa conduite dans l’arganeraie. Cela entraîner leur forte érosion et contribue à déstabiliser l’équilibre séculaire de ce système agraire articulé autour de trois productions : l’arganier (argane), la culture d’orge (tomzine) et l’élevage de petits ruminants, surtout la chèvre (taghate).
The degradation of the arganeraie is always the object of a debate relentless and lit by a considerable interest on behalf of the public, of the press and by the university circles. Several studies have been made to find explanations and solutions to this phenomenon. The majority of the results of this work suggest the negative consequences of goat farming on the argan ecosystem including the reduction of the surface is important and tends to accelerate and is no longer compensated spontaneously because the natural regeneration of argan no longer takes place and this because of several factors: urbanization; droughts; intensive and extensive crops under trees in the plains and plateaus (irrigated and rainfed), and most importantly, according to these studies, overgrazing by goat herders. In this study, we will not assess the validity of these results. However, our argument and the assumption that we choose is that the combination of overgrazing with other factors among which retain essentially the recent success of argan oil abroad will upset the ecological knowledge related to herd and conduct in the argan tree and cause them severe erosion, destabilizing secular equilibrium of the agrarian system that revolves around three productions: argan (argan), the barley crop (tomzine) and breeding small ruminants especially goats (taghate).
Maroc

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.10342
http://journals.openedition.org/etudescaribeennes/10342

Éditeur(s) : HAL CCSD Springer Verlag
Résumé :  
Genetic variation for intrinsic water use efficiency (W i) and related traits was estimated in a full-sib family of Quercus robur L. over 3 years. The genetic linkage map available for this F1 family was used to locate quantitative trait loci (QTL) for W i, as estimated by leaf carbon stable isotope composition (δ 13C) or the ratio of net CO2 assimilation rate (A) to stomatal conductance to water vapour (g w) and related leaf traits. Gas exchange measurements were used to standardize estimates of A and g w and to model the sensitivity of g w to leaf-to-air vapour pressure deficit (sgVPD). δ 13C varied by more than 3‰ among the siblings, which is equivalent to 40% variation of W i. Most of the studied traits exhibited high clonal mean repeatabilities (>50%; proportion of clonal mean variability in global variance). Repeatabilities for δ 13C, leaf mass per area (LMA) and leaf nitrogen content were higher than 70%. For δ 13C, ten QTLs were detected, one of which was detected repeatedly for all 3 years and consistently explained more than 20% of measured variance. Four genomic regions were found in which co-localizing traits linked variation in W i to variations in leaf chlorophyll and nitrogen content, LMA and sgVPD. A positive correlation using clonal means between δ 13C and A/g w, as well as a co-localisation of QTL detected for both traits, can be seen as validation of the theoretical model linking the genetic architecture of these two traits.
ISSN: 1614-2942

hal-01032066
https://hal.archives-ouvertes.fr/hal-01032066
DOI : 10.1007/s11295-007-0107-z

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
Purpose of review Toxoplasmosis in immunocompromised patients is associated with a high mortality rate. Molecular techniques are important tools to diagnose acute disease in immunocompromised patients, but there are various methods with variable efficiency. Some of them have been validated for the diagnosis of congenital toxoplasmosis, but the impact of their use has not been evaluated in immunocompromised patients. Recent findings Toxoplasmosis is of increasing importance in non-HIV immunocompromised patients. In addition, the picture of disease shows greater severity in South America, both in immunocompetent study participants and in congenitally infected infants. These epidemiological differences could influence the sensitivity of diagnostic methods. This review analyzes recent data on molecular diagnosis and compares them with older ones, in light of progress gained in molecular techniques and of recent epidemiological findings. Most recent studies were conducted in South America and used PCR targeting the B1 gene. PCR on blood could allow diagnosing a significant proportion of patients with ocular toxoplasmosis in Brazil. Summary Quantitative PCR methods with specific probes should be used to improve sensitivity and warrant specificity. Performance of quantitative PCR targeting the repeated 529 bp sequence for the diagnosis of toxoplasmosis in immunocompromised patients needs evaluation in field studies in South America and in western countries.
ISSN: 0951-7375

hal-01390970
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390970
DOI : 10.1097/QCO.0000000000000275
PUBMED : 27191201

Éditeur(s) : HAL CCSD SAGE Publications (UK and US)
Résumé : International audience
Molecular evolutionary analysis is an efficient method to predict and/or validate amino acid substitutions that could lead to a genetic disease and to highlight residues and motifs that could play an important role in the protein structure and/or function. We have applied such analysis to amelotin (AMTN), a recently identified enamel protein in the rat, mouse, and humans. An in silico search for AMTN provided 42 new mammalian sequences that were added to the 3 published sequences with which we performed the analysis using a dataset representative of all lineages (circa 220 million years of evolution), including 2 enamel-less species, sloth and armadillo. During evolution, of the 209 residues of human AMTN, 17 were unchanged and 34 had conserved their chemical properties. Substituting these important residues could lead to amelogenesis imperfecta (AI). Also, AMTN possesses a well-conserved signal peptide, 2 conserved motifs whose function is certainly important but unknown, and a putative phosphorylation site (SXE). In addition, the sequences of the 2 enamel-less species display mutations revealing that AMTN underwent pseudogenization, which suggests that AMTN is an enamel-specific protein.
ISSN: 0022-0345

hal-01545488
https://hal.archives-ouvertes.fr/hal-01545488
DOI : 10.1177/0022034512460551

Éditeur(s) : HAL CCSD IRD
Résumé : International audience
The number of satellites and remote sensing sensors devoted to earth observation becomes increasingly high, providing more and more data and especially images. In the same time the access to such a data and to the tools to process them has been considerably improved. In the presence of such data flow - and regarding the necessity to follow up and predict environmental and societal changes in highly dynamic socio-environmental contexts - we need automatic image interpretation methods. This could be accomplished by exploring some strengths of artificial intelligence. Our main idea consists in inducing classification rules that explicitly take into account structural knowledge, using Aleph, an Inductive Logic Programming (ILP) system. We applied our proposed methodology to three land cover/use maps of the French Guiana littoral. One hundred and forty six classification rules were induced for the 39 land-cover classes of the maps. These rules are expressed in first order logic language which make them intelligible and interpretable by non-experts. A ten-fold cross validation gave average values for classification accuracy, specificity and sensibility equal to, respectively, 98.82 %, 99.65% and 70%. The proposed methodology could be valuably exploited to automatically classify new objects and/or help operators using object-based classification procedures.
Symposium of the Latin American Society for Remote Sensing and Spatial Information Systems (SELPER)
Cayenne, French Guiana

ird-00797337
http://hal.ird.fr/ird-00797337
http://hal.ird.fr/ird-00797337/document
http://hal.ird.fr/ird-00797337/file/Bayoudh_et_al_2012_FP_SELPER-086.pdf
IRD : fdi:010058343

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Alkali feldspar thermochronologic modeling with the 40Ar/39Ar method has generated marked advances in knowledge of the mechanisms for argon diffusion in feldspars. While the goal in many cases has been to extrapolate the observed and modeled argon behavior in feldspars to natural geological settings, scientific debate surrounding the true feasibility of such extrapolations and indeed, the validity of thermochronologic modeling in itself, have provided much impetus to improve laboratory techniques to test, and increase basic understanding of, argon diffusion. Two cornerstones for the debate over the feasibility of alkali feldspar thermochronology for modeling natural, geologic processes have been: 1. is volume diffusion the main mechanism for argon movement in feldspars? and 2. if volume diffusion is a viable mechanism, does argon then reside in discrete ‘domains' within the feldspar lattice? We describe a study of alkali feldspars from a profile through a well-controlled brittle fault zone in western Norway; the feldspars document argon loss during deformation and strongly suggest the existence of argon ‘domains' within the feldspars, at least during laboratory step heating. The progressive change in the character of argon diffusion is recognizable in the logr/ro diffusion data from the feldspars and is mimicked by physical changes observed optically in the feldspars through progressive degrees of brittle deformation. Modeling results indicate a reduction in size of the biggest domains and the appearance of smaller domains during the strongest stages of deformation. Whether or not this reveals the existence and the transformation of the domain structure in naturo is difficult to prove from our data alone, but interestingly, this behaviour corresponds directly to the physical (optical) appearance of more intense crack networks and subgrains in progressively more brecciated feldspars. Because the thermochronologic histories derived from modeling the feldspar data conform very well to the known tectonic history of the area, the feldspars appear to have successfully retained physical (optical and isotopic) records of episodic tectonic processes operating from ductile through lowtemperature brittle regimes in rocks with a Caledonian history overprinted by several later (younger) geologic events. However, because the ‘cold' brecciation is the last tectonothermal event recorded by these rocks, it is impossible to truly test for the existence of diffusion domains in naturo. Argon loss appears to have been effective only in the most highly brecciated (deformed) samples where the combination of the connected crack network, increased fluid flow and higher temperatures enhanced diffusion via fast diffusion pathways and thus, volume diffusion from the lattice. Only minor argon loss occurred in zones of lower brittle strain, although some development of cracks and brittle features is evident. Independent of the existence of diffusion domains, this study highlights the possible pitfalls when cooling histories are deduced from brecciated feldspars in which age and diffusion charateristics have been decoupled: while the geochronological memory has survived and is identical to that of nonbrecciated feldspars (suggesting no loss and minor effects of deformation), the diffusion characteristics have been completely transposed by brecciation and the appearance of new domains. Modeling feldspars with these latter characteristics would effectively utilise a new feldspar diffusion structure with an ‘old' (relict) age memory.
ISSN: 0016-7037

hal-00198283
https://hal.archives-ouvertes.fr/hal-00198283
https://hal.archives-ouvertes.fr/hal-00198283/document
https://hal.archives-ouvertes.fr/hal-00198283/file/KsparBreccia_Arnaud_Eide_GCA_2000.pdf

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : International audience
We show first results of 3D simulation of sea currents in a realistic context. We use the full Navier-Stokes equations for incompressible viscous fluid. The problem is solved using a second order incremental projection method associated with the finite volume of the staggered (MAC) scheme for the spatial discretization. After validation on classical cases, it is used in a numerical simulation of the Pointe à Pitre harbour area. The use of the fictious domain method permits us to take into account the complexity of bathymetric data and allows us to work with regular meshes and thus preserves the efficiency essential for a 3D code.
ISSN: 1270-900X
Guidel, France

hal-00728894
https://hal.archives-ouvertes.fr/hal-00728894
DOI : 10.1051/proc/201235025

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
People are exposed to multiple pollutants, especially indoors. In the perspective of a cumulative risk assessment, a multi-residue analytical method was developed to assess the contamination of indoor suspended particulate matter by 55 semi-volatile organic compounds (SVOCs) including musk fragrances, organochlorines (OCs), organophosphates (OPs), polycyclic aromatic hydrocarbons (PAHs), polybromodiphenylethers (PBDEs), polychlorobiphenyls (PCBs), phthalates and pyrethroids. It is based on thermal desorption (TD) coupled with gas chromatography/mass spectrometry (GC/MS). Once the thermal desorption conditions were optimized, the method was validated in terms of quantification limits and accuracy using a standard reference material (SRM 2585). Instrumental quantification limits were 10pg (some OCs, some pyrethroids, musk fragrances, OPs, PAHs, PBDEs and PCBs), 100pg (phthalates and other OCs) and 1000pg (other pyrethroids) corresponding respectively to method quantification limits of 1, 10, and 100pg/m(3) for a sampled air volume of 20m(3). Calibration quadratic curves for ranges of 10-1000, 100-10,000, and 1000-100,000pg, depending on the substance, exhibit determination coefficients above 0.999. Recoveries were between 61 and 96% for chlorinated pesticides, PAHs, PBDEs and PCBs present in the SRM 2585. A test of the method on indoor particulate matter samples (PM(10)) collected on quartz fiber filters in French dwellings demonstrated its ability to quantify SVOCs from a small amount of PM.
ISSN: 0021-9673

hal-00732133
https://hal.archives-ouvertes.fr/hal-00732133
DOI : 10.1016/j.chroma.2012.07.025
PUBMED : 22840824

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : Geodynamic models incorporating metamorphic phase transformations almost invariably assume the validity of the Boussinesq approximation that violates conservation of mass. In such models metamorphic density changes take place without volumetric effects. We assess the impact of the Boussinesq approximation by comparing models of orogeny accompanied by lower crustal eclogitization both with and without the approximation. Our results demonstrate that the approximation may cause errors approaching 100 per cent in characteristic measures of orogenic shape. Mass conservation errors in Boussinesq models amplify with model time. Mass conservative models of metamorphism are therefore essential to understand long-term tectonic evolution and to assess the importance of the different geodynamic processes.
ISSN: 0956-540X

hal-00617480
https://hal.archives-ouvertes.fr/hal-00617480
DOI : 10.1111/j.1365-246X.2011.05052.x

Éditeur(s) : HAL CCSD Human Kinetics
Résumé : International audience
OBJECTIVE: The aim was to examine the relationship between physical activity pattern and dietary profile. Although some clustering of the variables related to these major determinants of cardiovascular risk has been demonstrated, they have not been extensively studied together. PARTICIPANTS, DESIGN, AND SETTING: Two hundred two female university students from the main Guadeloupe (French West Indies) campus participated. They self-administered a validated Food Frequency Questionnaire and the 1-yr recall Modifiable Activity Questionnaire. Principal-component analysis was performed on the scores and the variables related to the physical activity pattern and dietary profile. RESULTS: A model including 10 variables explained 84.9% of the total variance. The physical activity pattern was not associated with the dietary profile, apart from fruit intake. The physical activity level was homogeneously low (median 1.58, first and last quartile cutoffs 1.54 and 1.66, respectively). There was no correlation between the physical activity level and the Food Frequency Questionnaire score (r=-.005). CONCLUSIONS: The absence of a strong relationship between the food and physical activity profiles is interpreted as a possible reflection of a dysregulation of the quality of food intake in this population with a sedentary lifestyle.
ISSN: 1526-484X

hal-00748203
https://hal.archives-ouvertes.fr/hal-00748203
DOI : 10.1123/ijsnem.20.5.401
PUBMED : 20975108

Éditeur(s) : HAL CCSD Elsevier
Résumé : The Gulf of Aigues-Mortes (NW Mediterranean Sea) is a midshelf zone whose scale is an intermediate between the nearshore scale (0–10 m depth) and the coastal scale (including the whole continental shelf). Its hydrodynamics is investigated for the first time. ADCP, CTD and thermosalinograph data were collected during three short cruises (HYGAM; March 6–7, 20–21, April 5–6, 2005). They were scheduled approximately every 15 days to sample the gulf circulation under different weather conditions. Moreover, the cruise data were used to validate the Symphonie model, a 3D primitive equations circulation model. The circulation features displayed by in situ data were well reproduced by Symphonie. A downscaling modelling approach was implemented, the largest scale being obtained by the replay of the MFSTEP regional model of the North-Western Mediterranean Sea. The analysis, closely coupling in situ measurements and model results, provides information that would not have been obtained using data separately. The great variability of the oceanic circulation at this scale is well evidenced. Winds are the main forces, not only locally but also at a larger scale. North winds generate coherent structures interacting with the general Mediterranean circulation. The explanation of the induced currents is then not straightforward, some of them being, for example, northward. South and southeast winds reinforce the sloping surface, the latter allowing the geostrophic equilibrium with longshore currents. This study, focused on the end of winter 2004–2005, also enhances the heat fluxes from offshore to nearshore, as well as the initiation of shelf dense waters. The knowledge of the midshelf oceanic circulation is then applied to run a numerical experiment which describes both the dispersion of a fictive contaminant from a point S (at the centre of the GAM), and evaluates the risk of contamination of the beaches along the GAM shores.
ISSN: 0278-4343

hal-00196620
https://hal.archives-ouvertes.fr/hal-00196620
DOI : 10.1016/j.csr.2007.06.006

Éditeur(s) : HAL CCSD
Résumé : International audience
We propose an algorithm based on a model of visual perception that is meant to reflect the human judgment about the similarity of handwritten samples. The algorithm builds upon the Fuzzy Feature Contrast model and proposes an implementation of such a model in the domain of handwriting. The algorithm has been validated on the RIMES dataset, by comparing its performance with those of a panel of human experts. The experimental results show that the performance of the proposed algorithm is almost indistinguishable from the expert one and therefore may be a viable tool for handwriting comparison.
17th Biennial Conference of the International Graphonomics Society
Pointe-à-Pitre, Guadeloupe

hal-01165766
https://hal.univ-antilles.fr/hal-01165766
https://hal.univ-antilles.fr/hal-01165766/document
https://hal.univ-antilles.fr/hal-01165766/file/IGS_2015_submission_5.pdf

Éditeur(s) : HAL CCSD SAGE Publications (UK and US)
Résumé : International audience
In this article, we focus on hypomaturation autosomal-recessive-type amelogenesis imperfecta (type IIA2) and describe 2 new causal Matrix metalloproteinase 20 (MMP20) mutations validated in two unrelated families: a missense mutation p.T130I at the expected homozygous state, and a compound heterozygous mutation having the same mutation combined with a nucleotide deletion, leading to a premature stop codon (p.N120fz*2). We characterized the enamel structure of the latter case using scanning electron microscopy analysis and microanalysis (Energy-dispersive X-ray Spectroscopy, EDX) and confirmed the hypomaturation-type amelogenesis imperfecta as identified in the clinical diagnosis. The mineralized content was slightly decreased, with magnesium substituting for calcium in the crystal structure. The anomalies affected enamel with minimal inter-rod enamel present and apatite crystals perpendicular to the enamel prisms, suggesting a possible new role for MMP20 in enamel formation.
ISSN: 0022-0345

hal-01545484
https://hal.archives-ouvertes.fr/hal-01545484
DOI : 10.1177/0022034513488393

Éditeur(s) : HAL CCSD
Résumé :  
For a comprehensive evaluation of human influences on the genetic system, the simulation model EGO-GENE was developed. The model combines population genetic and population dynamic processes with forest growth models. The dynamics of genetic structures (single locus and multilocus genotypes up to 200 loci) can be simulated. Spatial and temporal genetic dynamics are included in the model. Overlapping or separated generations can be created and different modes of mating systems can be implemented. The model can be run with empirical and fictitious input data. The simulated genetic structures can be directly analysed with established genetic analysis programmes. An example demonstrates the use of the model far validation of interactions among components of the mating system. Another example demonstrates the applicability of the model in decision-making for seed sampling strategies. The genetic differences between the adult trees and the harvested seeds and the danger of genetic drift regarding to different seed sampling strategies are investigated by use of the genetic distance and the reproductively effective population size.
Silvae genetica

hal-01032083
https://hal.archives-ouvertes.fr/hal-01032083

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Introduction: The selection of patients with metastatic clear cell renal cell carcinoma (ccRCC) who may benefit from targeted tyrosine kinase inhibitors has been a challenge, even more so now with the advent of new therapies. Hilar fat infiltration (HFI) is a validated prognostic factor in nonmetastatic ccRCC (TNM 2009 staging system) but has never been studied in metastatic patients. We aimed to assess its phenotype and prognostic effect in patients with metastatic ccRCC treated with first-line sunitinib.Materials and methods: In a multicentric study, we retrospectively included 90 patients and studied the corresponding ccRCC at the pathological, immunohistochemical, and molecular levels. Patient and tumor characteristics were compared using univariate and multivariate analysis. All the features were then studied by Cox models for prognostic effect.Results: HFI was found in 42 patients (46.7%), who had worse prognosis (Heng criteria) (P = 0.003), liver metastases (P = 0.036), and progressive diseases at first radiological evaluation (P = 0.024). The corresponding ccRCC was associated with poor pathological prognostic factors that are well known in nonmetastatic ccRCC. For these patients, median progression-free survival was 4 months vs. 13 months (P = 0.02), and median overall survival was 14 months vs. 29 months (P = 0.006). In a multivariate Cox model integrating all the variables, only poor prognosis, according to the Heng criteria and HFI, remained independently associated with both progression-free survival and overall survival.Conclusion: HFI was demonstrated for the first time to be an independent poor prognostic factor. Its potential role in predicting resistance to antiangiogenic therapy warrants further investigation.
ISSN: 1078-1439

hal-01632553
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01632553
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01632553/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01632553/file/Hilar%20fat%20infiltration_accepted.pdf
DOI : 10.1016/j.urolonc.2017.05.015