Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : National audience
Objectif Analyser les caractéristiques virologiques et les complications des syndromes grippaux chez les diabétiques en période hivernale. Patients et Méthodes Étude conduite dans 6 hôpitaux (Montpellier, Lyon, Cochin, Bichat, Limoges, Rennes) au cours de 3 saisons grippales (2012-2013, 2013-2014 et 2014-2015), sur 1 451 adultes hospitalisés avec syndrome grippal récent (début ≤ 7 jours), associant un signe respiratoire (toux, dys-pnée) et un signe systémique (fièvre, céphalées, malaise, myalgies). Les virus respiratoires étaient recherchés par RT-PCR sur prélèvement naso-pharyngé ou LBA (Centre National de Référence, Lyon). La vaccination anti-grippale, la présence d'un diabète, les comorbidités, les complications en cours d'hospitalisation (insuffisance rénale, cardiaque, respiratoire, pneumonie, décès) et la durée moyenne de séjour (DMS) étaient enregistrées. Les facteurs de risque de complications ont été étudiés par régression logistique multivariée ajustée sur âge, sexe, infection grippale, vaccination, diabète et antécédents de pathologies rénale, cardiaque ou respiratoire. Résultats Les hospitalisations ont eu lieu dans des services de maladies respiratoires, médecine interne, MIT et réanimation. Un diabète était présent chez 368 sujets (non traités : 15 %, ADO : 41 %, insuline : 27 %, mixte : 17 %). Les diabétiques étaient plus âgés (71 ± 15 vs 65 ± 20 ans, P < 0,001) et présentaient plus souvent un antécédent de pathologie rénale (18 % vs 8 %, P < 0,00001) ou cardiaque (19 % vs 11 %, P < 0,001). Leur couverture vaccinale était meilleure (60 % vs 46 %). Les données virologiques étaient comparables : grippe 38,9 % (76,1 % type A) vs 39,2 % ; (74,1 % type A) ; autres virus respiratoires : 17,0 % vs 19,9 %. La DMS était un peu plus élevée chez les diabétiques (9,1 ± 9 vs 8,9 ± 11, P = 0,015), avec une tendance à un risque de décès plus élevé (6,25 % vs 3,97 %, P 0,07). En analyse multivariée, le diabète était un facteur de risque de complications à type d'insuffisance rénale (OR : 1,66, IC 95 % : 1,10-2,52) mais pas d'insuffisance cardiaque, respiratoire ou de décès. Les complications n'étaient pas modi-fiées par les résultats virologiques. Conclusions Le diabète est un facteur de risque de complications rénales chez les patients hospitalisés avec syndrome grippal
ISSN: 1262-3636

hal-01300779
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01300779
DOI : 10.1016/S1262-3636(16)30020-9

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : Fire-free forest conversion with organic inputs as an alternative to slash-and-burn could improve agro-ecosystem sustainability. We assessed soil carbon mass changes in a sandy-clayey and well-drained soil in French Guiana after forest clearing by the chop-and-mulch method and crop establishment. At the experimental site of Combi, native forest was cut down in October 2008; woody biomass was chopped and incorporated into the top 20 cm of soil. After about one year of legume and grass cover, three forms of land management were compared: grassland (Urochloa ruziziensis), maize/soybean crop rotation with disk tillage and in direct seeding without tillage. There were four replicates. We measured 14.16 kg m(-2) of carbon in 2 mm-sieved soil down to 2 m depth for the initial forest. Forest clearing did not induce significant soil compaction; neither did any specific agricultural practice. In converted soils, C stocks were measured in the 0-30 cm layer after each crop for three years. Carbon mass changes for soil fractions <2 mm (soil C stock) and >2 mm (soil C pool) in the 0-5, 5-10, 10-20 and 20-30 cm soil layers were assessed on an equivalent soil mass basis. One year and 1.5 years after deforestation, higher C stocks (+0.64 to 1.16 kg C m(-2) yr(-1)) and C pools (+0.52 to 0.90 kg C m(-2) yr(-1)) were measured in converted soils, compared to those of the forest into the top 30 cm of soil. However, the masses of carbon in these converted soils declined later. The highest rates of carbon decrease were measured between 1.5 and 2 years after forest conversion in the <2 mm soil fraction, from 0.46 kg Cm-2 yr(-1) (in grassland soils) to 0.71 kg C m(-2) yr(-1) (in cropland under no tillage). The carbon pool declined during the third year at rates of 0.41 kg C m(-2) yr(-1) (cropland under disk tillage) to 0.76 kg C m(-2) yr(-1) (grassland soils). Three years after forest conversion, C masses in the top 30 cm of soils for grassland showed similar values than for forest. In comparison, the carbon stock in cropped soils managed under no tillage in direct seeding (without mulch) was significantly 17% and 16% lower than in forest and grassland soils, respectively. None of the studied agricultural practices succeeded in accumulating carbon from the chopped forest biomass.
ISSN: 0167-8809

hal-01032438
https://hal.archives-ouvertes.fr/hal-01032438
DOI : 10.1016/j.agee.2013.11.009

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Symbioses with the dinoflagellate Symbiodinium are widespread among marine invertebrates and protists, especially in nutritionally demanding habitats, such as tropical coral reefs, where they play a major role in ecosystem survival. Moreover, apart from corals and sea anemones, many of the Symbiodinium species and clades involved in these partnerships remain to be characterized. This study provides new insights into nudibranch and sponge associations with Symbiodinium by sequencing regions of the Symbiodinium 28S rDNA and the host mitochondrial COI oxidase. Specimens were sampled between 2011 and 2013 from locations around the islands of Moorea and Tahiti, French Polynesia. Our results revealed that some of the sponges and nudibranchs harbored typical Symbiodinium from clade B or C while others harbored new, undescribed Symbiodinium-like dinoflagellates. A detailed analysis of the different life stages of the nudibranch Phestilla lugubris and of its specific coral prey, Porites rus, suggests a prey-predator horizontal transfer of the symbiont and its vertical inheritance from the parent to the eggs.
Les symbioses à zooxanthelles, dinoflagellés du genre Symbiodinium, sont largement répandues chez les invertébrés marins et les protozoaires, notamment dans les eaux oligotrophes, où ils jouent un rôle important dans la survie des récifs coralliens. De plus, excepté chez les coraux et les anémones, les différentes espèces et clades de Symbiodinium impliqués dans ces associations restent à être caractérisés. Notre étude, grâce à l’utilisation des marqueurs génétiques 28S ADNr des Symbiodinium et la sous-unité 1 de la cytochrome oxydase mitochondriale (COI) de l’hôte, procure de nouvelles données quant aux associations des éponges et des nudibranches avec les Symbiodinium. L’échantillonnage a eu lieu autour de Moorea et de Tahiti (Polynésie française), entre 2011 et 2013. Nos résultats révèlent que certaines espèces d’éponges et de nudibranches possèdent les clades B et C communément retrouvés, chez les coraux notamment, alors que d’autres présentent de nouveaux dinoflagellés « Symbiodinium-like ». Une analyses détaillée des Symbiodinium à différents stades du cycle de vie du nudibranche corallivore Phestilla lugubris et de son corail hôte Porites rus suggèrent l’existence d’un transfert horizontal de Symbiodinium proie–prédateur et un transfert vertical du parent P. lugubris à ses œufs.
ISSN: 1631-0691

hal-01145518
https://hal.archives-ouvertes.fr/hal-01145518
DOI : 10.1016/j.crvi.2015.01.005

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Adult lymphatic filariae (Wuchereria bancrofti, Brugia malayi) can cause blocking of lymphatics producing obliterating endolymphitis lesions. The subsequent extravasation of lymph (or chyle when the obstruction is canal) is at the origin of the formation of lymphedema or elephantiasis, in which the main histological finding is great hypertrophy of collagen elements. This theory involving filaria only is not the full picture, and bacterial infection, mainly by streptococci, is an important factor. The association of filaria with microbes is particularly dangerous because the presence of the latter, or its toxins, causes death of local microfilariae and even adult worms, which are known to be more harmful dead than alive. The progression of the disease, especially in cases with lymphedema, which mainly affects the limbs and the genital organs, depends on three factors: the species of filaria, the degree of transmission, and the receptivity of the patient to the parasite. Large differences are found according to the region involved, and in the same endemic zone, according to the individuals affected. However, they almost always occur progressively in areas where there have been recurrent attacks of acute lymphangitis.
ISSN: 0398-0499

hal-00715440
https://hal.univ-antilles.fr/hal-00715440
PUBMED : 7007545

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
ISSN: 0761-8425

hal-01117908
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117908
DOI : 10.1016/j.rmr.2013.09.015
PUBMED : 25239580

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
The diagnosis of diabetic foot infections is difficult due to limitations of conventional culture-based techniques. The objective of this study was to evaluate the contribution of denaturing gradient gel electrophoresis (DGGE) in the microbiological diagnosis of diabetic foot ulcers in comparison to conventional techniques, and also to evaluate the need to perform a biopsy sample for this diagnosis. Twenty diabetic patients (types 1 and 2) with foot ulcers (grades 1-4) were included. After debridement of their wounds, samples were taken in duplicate by surface swabbing and deep-tissue biopsy. The samples were analyzed by conventional culture and by a new molecular biology tool, DGGE technology. Polymerase chain reaction (PCR)-DGGE led to the identification of more bacteria than did conventional cultures (mean: 2.35 vs 0.80, respectively). In 11 cases, the technology detected pathogenic species not isolated by classical cultures. PCR-DGGE also identified significantly more pathogenic species at deep levels compared with species detected at superficial levels (87% vs 58%, respectively; P = 0.03). In 9/20 cases, pathogenic bacteria were detected only in deep samples, revealing the need to perform tissue biopsy sampling. DGGE, achievable in 48h, could be a useful technique for the bacteriological diagnosis of diabetic foot infections. It may help to identify pathogenic bacteria in deeply infected ulcers, thereby contributing to a more appropriate use of antibiotics.
ISSN: 1262-3636

hal-01122240
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122240
DOI : 10.1016/j.diabet.2014.03.002
PUBMED : 24751989

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : National audience
Objectifs Évaluer les connaissances des médecins généralistes et des pharmaciens d'officine en matière de dopage sportif, Populations et méthodes Deux études descriptives transversales par questionnaire anonyme ont été menées en 2006 et 2009 respectivement chez 280 pharmaciens et 992 médecins. Résultats Ils estiment que la plupart des records sont battus grâce au dopage et que les champions y recourent. Selon eux, les sports les plus touchés sont le cyclisme, l'athlétisme, le football, l'haltérophilie et la natation. Ils méconnaissent la liste des produits interdits. Pour eux, les personnes proches des sportifs et Internet sont les principales sources d'approvisionnement en dopants. Seuls 42 % des médecins et 35 % des pharmaciens pensent informer un patient sportif sur les produits pouvant positiver un contrôle antidopage. On note que 51,5 % des médecins ne connaissent pas les autorisations d'usage à des fins thérapeutiques et 90 % ignorent l'existence des antennes médicales de prévention du dopage. Ils déclarent ne pas avoir reçu d'enseignement universitaire spécifique sur le dopage et s'estiment mal informés. Conclusion Les médecins généralistes et les pharmaciens d'officine ne semblent pas disposer de connaissances suffisantes pour assurer leurs missions et pour prendre conscience de leurs responsabilités dans la lutte antidopage.
ISSN: 0765-1597

hal-01010769
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010769
DOI : 10.1016/j.scispo.2013.10.004

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
ISSN: 0033-2984

hal-01678151
https://hal.univ-antilles.fr/hal-01678151
DOI : 10.1016/j.psfr.2014.04.002

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : National audience
INTRODUCTION:The AIRBAg study screens for bronchial obstruction in dairy farmers. We present the preliminary results after one year.METHODS:A prospective screening study based on questionnaires and electronic mini-spirometry (Néo-6(®)) that includes a representative sample of dairy farmers from the departments of Morbihan and Île-et-Vilaine in Brittany. The dairy farmers had an occupational medicine appointment and, if they demonstrated at least one marker of possible bronchial obstruction (chronic cough, chronic bronchitis, dyspnoea, wheezing, FEV1/FEV6<0.8), they were referred to a pulmonologist. The data we present here were extracted from the occupational medicine appointments because the pulmonologists' appointments are still running.RESULTS:Among the 277 dairy farmers included, 125 (45%) demonstrated "possible bronchial obstruction". The total score of the CAT questionnaire was higher in these farmers (9.1±6.2 versus 5.8±4.0; P<0.0001). In multivariate analysis markers of "possible bronchial obstruction" were eczema, manual foddering and duration of mechanical straw litter spreading.CONCLUSION:Occupational medicine appointments identified markers of "possible bronchial obstruction". We will have the complete results from AIRBAg study in 2015.
ISSN: 0761-8425

hal-01117944
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117944
DOI : 10.1016/j.rmr.2014.03.014
PUBMED : 25847201

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : Le cancer de la prostate est le cancer le plus fréquent chez l'homme dans la majorité des pays occidentaux. Certains facteurs de risque sont bien identifiés (âge, antécédents familiaux, origine ethnique) mais son étiologie reste largement méconnue. Les substances chimiques d'origine anthropique suscitent de nombreuses interrogations quant à leur rôle dans la survenue de la maladie. Divers travaux ont montré, de manière consistante, la présence d'un excès de risque de cancer de la prostate chez les populations agricoles par rapport à la population générale. Cependant, l'hypothèse qu'un tel excès de risque soit relié à l'utilisation de pesticides n'a pas encore été formellement démontrée.
ISSN: 1166-7087

hal-00671956
https://hal.archives-ouvertes.fr/hal-00671956

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : Reconstruction of Northern African monsoon between 6.2 and 4.9 Ma and possible relationships with Late Miocene events. Mineralogical and geochemical investigations have been realized on ODP Site 659 in order to better understand the detrital sedimentation of the Cap Verde plateau and to reconstruct African monsoon intensity variations between 6.2 and 4.9 Ma. Time intervals corresponding to an intensification of the summer African monsoon rainfall are associated to a reduction of eolian input from the Sahara and an intensification of the African river input. The reflooding of the Mediterranean Sea at the end of the Messinian salinity crisis (MSC) (5.33 Ma) is correlated to a greater aridity in the Sahara.
ISSN: 1631-0713

hal-00412151
https://hal.archives-ouvertes.fr/hal-00412151
DOI : 10.1016/j.crte.2008.07.005

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Autostatic ureteral stents have been commonly used in urology for more than 20 years. Encrustation is a frequent and well described phenomenon that sometimes makes stent removal difficult. The main predisposing factors are: duration of stenting, history or concomitant stone disease, urinary tract infection or bacterial colonization, pregnancy and chemotherapy. Treatment depends on the degree of encrustation, especially when it involves the proximal loop. Extracorporeal lithotripsy alone or combined with endoscopic treatment is very effective, but open surgery may sometimes be necessary. The authors report a case in which drainage was exceptionally prolonged as the stent was removed after a period of 10 years. Stent removal required 3 operations, including one open procedure. The steps of treatment are described and the aetiologies of encrustation and the therapeutic strategy are discussed.
ISSN: 1166-7087

hal-00697503
https://hal.archives-ouvertes.fr/hal-00697503
PUBMED : 16734247

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Une surface d'émersion majeure (S1) au sein de l'unité récifale Pliocène supérieur à Pléistocène inférieur des « calcaires supérieurs » de Grande-Terre (avant-arc des Petites Antilles) révèle une baisse du niveau marin relatif d'au moins 60 m et permet de définir un nouveau découpage stratigraphique. S1 est surmontée par un cortège transgressif sablo-calcaire, puis par une formation récifale à Acropora. L'ensemble représente l'enregistrement d'un cycle eustatique complet par cette plateforme carbonatée de marge active. La comparaison avec la plate-forme carbonatée de marge stable du banc des Bahamas permet d'estimer que S1 correspond à l'émersion majeure de 1,66 Ma et qu'elle est d'origine glacio-eustatique.
ISSN: 1631-0713

hal-00180663
https://hal.archives-ouvertes.fr/hal-00180663
DOI : 10.1016/j.crte.2005.01.012

Éditeur(s) : HAL CCSD Paris, Masson et Cie
Résumé : National audience
Decreased frequency of pulmonary exacerbations, mainly related to immunomodulatory effects of macrolide antibiotics, has been demonstrated in bronchiectasis and chronic obstructive pulmonary diseases (COPD). Due to its tolerance, azithromycin is the antibiotic of choice for maintenance therapy at the dose of 250 mg per day or 500 mg × 3 per week (for body weight >55 kg). Maintenance therapy with macrolide could be proposed in selected patients with bronchiectasis or COPD with more than 3 acute exacerbations in the previous year or decreased lung function despite compliance with optimum treatment. The risk of sudden cardiac death with azithromycin is rare and controversial. It should be avoided in patients with a high baseline risk of cardiovascular disease, QT>450 msec, pulse rate>100 bpm and potential drug interactions, particularly those known to cause QT prolongation. It is recommended to search for hearing deficit (audiometry) and sputum culture positive for mycobacteria. Patients must also be aware that it can rapidly lead to macrolide resistance in commensal or pathogenic flora. Follow-up evaluation every 3 month can be proposed with medical history (hearing deficit) and electrocardiography. After one year, the treatment should be stopped in the absence of reduction in the frequency of exacerbations.
Points essentielsLes macrolides administrés au long cours permettent, grâce en partie à leurs propriétés anti-inflammatoires, de diminuer la fréquence des exacerbations dans la DDB et la BPCO.Du fait de sa tolérance, l’azithromycine est le macrolide de choix, pouvant être utilisé à la dose de 250 mg/j ou 500 mg 3 fois par semaine chez les patients de plus de 55 kg.Un traitement par macrolides au long cours pourrait être proposé à des patients atteints de DDB ou de BPCO ayant eu plus de 3 exacerbations l’année précédente ou ayant une dégradation de leur fonction respiratoire malgré un traitement de fond bien conduit.Du fait d’un risque rare et controversé de mort subite d’origine cardiaque, il ne doit pas être proposé en cas de pathologie cardiovasculaire évoluée, d’intervalle QT > 450 ms, de traitement pouvant allonger l’intervalle QT, de tachycardie > 100/min.Il est recommandé de s’assurer de l’absence de troubles auditifs (audiogramme) et de mycobactérie atypique dans les cultures des expectorations. Les patients doivent aussi être informés du risque d’apparition de résistance aux macrolides de la flore commensale et pathogène.Une surveillance clinique, avec en particulier la recherche de troubles auditifs et électrocardiographique, peut être proposée tous les 3 mois. L’absence de diminution de la fréquence des exacerbations, lors du bilan annuel, justifie l’arrêt du traitement.
ISSN: 0032-7867

hal-01073027
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01073027
DOI : 10.1016/j.lpm.2013.08.006
PUBMED : 24631048

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : In Vietnam, the Triassic Indosinian collision affected coevally the Truong Son belt and the Kontum Massif,which were not independent tectonic units, but parts of the same Gondwana-derived Indochina continental block. This thermotectonic event took place synchronously throughout Vietnam, during the Lower Triassic 250-240-Ma time interval, as demonstrated by numerous geochronological data, combining Ar-Ar and U-Pb dating methods. Structural and kinematic investigations, in the Indosinian metamorphic rocks, reveal that the collisional process resulted from a consistent northwest-striking convergence of Indochina with respect to the adjacent blocks. It is suggested that this motion was taken up by a pair of opposite subduction zones: to the north, beneath South China, and to the west, beneath western Indochina, along the Song Ma and Po Ko sutures, respectively. Tectonic markers, calc-alkaline subduction-related volcanism and granitic intrusions and the generation of high-pressure rocks that have been recently discovered support this geodynamic setting, at least along Po Ko. Along the northwest-trending Song Ma zone, the obliquity of the convergence during subduction and subsequent collision resulted in the development, within the Truong Son Belt, of a set of subparallel dextral mylonitic shear zones, under amphibolite-facies metamorphism. The intermediate segments remained weakly metamorphic or even almost devoid of metamorphism. Along Po Ko, the convergence was near-orthogonal, with a left-lateral strike-slip component; the ongoing continental subduction resulted in the reworking of the Kontum granulitic basement and the development of Indosinian HP granulitic conditions; the subsequent extension-related exhumation operated approximately in the same northwestwards direction. This Indosinian evolution, applied on a continental crust that had been probably affected, as in South China, by a Caledonian-related event, as judged by the general unconformity of the Lower Devonian sediments, the widespread occurrence of magmatic crystallisation ages of ca 450 Ma (Ordovician-Silurian), and by the approximately similar age of the primary granulitic episode in the Kontum Massif. The similarities of the Devonian facies over central, northern Vietnam and South China imply a land connection, possibly as a consequence of a Caledonian collision along Song Ma, but this does not preclude a further oceanic opening and a closure during the Indosinian.
ISSN: 1631-0713

hal-00411591
https://hal.archives-ouvertes.fr/hal-00411591
DOI : 10.1016/j.crte.2007.10.005

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : Extension fractures of two types defined by the mean stress σ were generated in a synthetic rock analogue material. When σ is very small, the fractures are mode I cracks with smooth surfaces. At higher σ, these surfaces have plumose topography, with the amplitude increasing with σ. Both SEM observations and mechanical measurements show that fractures/discontinuities in the latter case are initiated as dilatancy localization bands. They form under tensile or slightly compressive normal stress and can be seen as running constitutive instabilities. The similarity between the plumose fractography of the experimental fractures and natural joints suggests similarity in the formation mechanism.
ISSN: 1631-0721

hal-00585886
https://hal.archives-ouvertes.fr/hal-00585886
DOI : 10.1016/j.crme.2011.01.002

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Objectifs. - Évaluer les effets du triathlon classique (1,5 km natation, 40 km cyclisme, 10 km course à pied) sur la capacité de diffusion pulmonaire (DLCO) 24 heures après la compétition. Méthodes et résultats. - Dix triathlètes masculins (21,5 ± 2,8 ans) ont effectué une spirométrie et une mesure de la capacité de diffusion pulmonaire avant la compétition (pré-T) et 24 heures après l'épreuve (post-T). Les résultats montrent une diminution significative du volume expiratoire maximal en 1 s (5,17 ± 0,4 L.s-1 contre 4,09 ± 0,6 L.s-1) et du débit expiratoire maximal 25-75 % de la capacité vitale (6,98 ± 0,2 L.s-1 contre 4,90 ± 0,2 L.s-1). En revanche, les résultats ne montrent pas de différence significative entre les DLCO pré-T et post-T (38,1 ± 3,3 mL.min-1.mmHg-1 contre 37,1 ± 3,7 mL.min-1.mmHg-1) ni les ratios DLCO/VA (5,59 ± 0,5 mL.min-1.mmHg-1.A-1 contre 5,55 ± 0,7 ml.min-1.mmHg-1.A-1). Conclusion. - La DLCO est normale chez les triathlètes 24 heures après une compétition classique. Ceci peut traduire l'absence de lésions alvéolocapillaires pendant le triathlon. La baisse de la DLCO rapportée deux heures après un exercice dans la littérature peut s'expliquer par la baisse du volume sanguin pulmonaire qui apparaît comme un phénomène transitoire. Cependant, la baisse des débits pulmonaires observée 24 heures après le triathlon suggère la persistance chez les triathlètes d'un syndrome obstructif bronchique.
ISSN: 0765-1597

hal-00720522
https://hal.univ-antilles.fr/hal-00720522
https://hal.univ-antilles.fr/hal-00720522/document
https://hal.univ-antilles.fr/hal-00720522/file/Article_3_.pdf

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
The Chaînons Béarnais ranges (North-Pyrenean Zone, west-central Pyrenees) display a fold-and-thrust structure involving the Mesozoic sedimentary cover, decoupled from its substratum at the Keuper evaporites level and associated with a few peridotite bodies and scarce Palaeozoic basement lenses. In the western part of the Chaînons Béarnais, the newly described recumbent fold of the Saraillé massif comprises a peridotite body and several lenses of Palaeozoic basement wrapped by the Triassic to Aptian sedimentary cover. This structure represents a remnant of the distal portion of the Pyrenean paleo-rifted margin where mantle rocks have been exhumed during Albian–Cenomanian times. In this paper, we present the first detailed mapping and microstructural analysis of the Saraillé massif, providing new geological basis for reconstructing the evolution of this part of the paleo-margin. Our mapping (i) shows that the pre-rift Mesozoic cover forms a recumbent fold cored by mantle and crustal rocks and (ii) confirms that the prerift cover was detached from its bedrock along a layer of Triassic evaporites and slid onto the exhumed mantle rocks. Sliding of the prerift cover was associated with extreme crustal thinning and mantle exhumation along a major detachment fault, together with intense metasomatism affecting both the continental basement and the sedimentary cover. We show for the first time (1) that the Mesozoic pre-rift sediments experienced syn-metamorphic ductile thinning during mantle exhumation, and (2) that during its extreme attenuation, the continental basement was reduced to tectonic lenses some ten meters thick by ductile shearing.
ISSN: 1631-0713

insu-01265777
https://hal-insu.archives-ouvertes.fr/insu-01265777
https://hal-insu.archives-ouvertes.fr/insu-01265777/document
https://hal-insu.archives-ouvertes.fr/insu-01265777/file/corre-CRGeosc-2016.pdf
DOI : 10.1016/j.crte.2015.11.007

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
INTRODUCTION: Hydroxyurea is an antimetabolite drug used in the treatment of myeloproliferative disorders. Common adverse effects include haematological, gastrointestinal cutaneous manifestations, and fever. Hydroxyurea-induced pneumonitis is unusual. CASE REPORT: A female patient was treated with hydroxyurea for polycythemia vera. She was admitted 20 days after commencing treatment with a high fever, productive cough, clear sputum and nausea. A chest CT-scan showed diffuse ground-glass opacities. Microbiological investigations were negative. The symptoms disappeared a few days after discontinuation of the drug and rechallenge led to a relapse of symptoms. CONCLUSION: Our case and 15 earlier cases of hydroxyurea-induced pneumonitis are reviewed. Two patterns of this disease may exist: an acute febrile form occurring within 1 month of introduction of hydroxyurea and a subacute form without fever. Even if uncommon, one should be aware of this complication of hydroxyurea.
Revue des Maladies Respiratoires

hal-01072996
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01072996
DOI : 10.1016/j.rmr.2013.09.001
PUBMED : 24878159

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Late Jurassic coral reefs are present in the Western High Atlas of Morocco along the eastern paleomargin of the young Atlantic Ocean. The Izwarn section shows two reef units made of scleractinian corals and microbialites, included in a progradational shallowing-upward succession. Changes in reefal composition and structure observed in a ca. 50 cm-thick interval at the base of the reef unit 1 are interpreted to represent the first well-documented ecological succession in Late Jurassic reefs. Bioclastic deposits, sparse and poorly diversified corals (five genera) preserved in life position, and finally a more diversified coral assemblage (11 genera) building a reef framework with stromatolitic crusts reflect pioneer, colonization and diversification stages, respectively. A specific depth window, where light was reduced but sufficient for a catch-up growth mode and below the erosive action of waves, probably at the lower slope of a fore-reef area, has made possible the development and the record of this ecological succession. With a more diversified coral assemblage (16 genera), the reef unit 2 reflects shallower and well-agitated waters of a fore-reef area. Overlaying this second reef unit, the upper part of the section reveals back-reef deposits made of reworked reef elements, whereas a putative reef crest area is not recorded.
ISSN: 0016-6995

hal-00795549
https://hal.archives-ouvertes.fr/hal-00795549
DOI : 10.1016/j.geobios.2012.05.002