Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
ISSN: 1779-0980

hal-01624740
https://hal.archives-ouvertes.fr/hal-01624740
DOI : 10.4000/etudescaribeennes.414

Éditeur(s) : HAL CCSD Taylor & Francis (Routledge)
Résumé : International audience
The French Antilles (Martinique, Saint Martin and Guadeloupe) and French Guiana are the French territories most affected by the HIV epidemic. Some population groups such as men who have sex with men (MSM), especially those involved in transactional sex, are thought to be particularly vulnerable to HIV but few data exist to help characterize their health-related needs and thus implement relevant prevention interventions. To fill this knowledge gap, we used data collected from an HIV/AIDS Knowledge, Attitudes, Behaviours and Practices survey conducted in 2012 among MSM living in the French Antilles and French Guiana and recruited through snowball sampling. Our objectives were to compare social and demographic characteristics and sexual behaviours between MSM engaging in transactional sex and MSM not engaging in transactional sex and to identify factors associated with transactional sex involvement using a logistic regression model. A total of 733 MSM were interviewed, 21% of whom reported to undergo transactional sex. Their behaviour and social and demographic characteristics were different from other MSMs’ and they were more exposed to factors that are recognized to potentiate HIVvulnerability, at the individual, community, network and structural levels. The variables positively associated with sex trade involvement were having ever consumed drug (OR = 2.84 [1.23–6.52]; p = .002), having a greater number of sex partners than the median (OR = 8.31 [4.84–14.30]; p < .001), having experienced intimate partner violence (OR = 1.72 [0.99–3.00]; p = .053) and having undergone physical aggression because of sexual orientation (OR = 2.84 [1.23–6.52];p = .014). Variables negatively associated with sex trade involvement were being older (OR = 0.93 [0.90–0.97] per year; p = .001), having a stable administrative situation (OR = 0.10 [0.06–0.19]; p < .001), having a stable housing (OR = 0.29 [0.15–0.55]; p < .001) and being employed full-time (OR = 0.29 [1.23–6.52]; p = .002).
ISSN: 0954-0121

inserm-01407263
http://www.hal.inserm.fr/inserm-01407263
http://www.hal.inserm.fr/inserm-01407263/document
http://www.hal.inserm.fr/inserm-01407263/file/AIDS%20Care%20final%20version.pdf
DOI : 10.1080/09540121.2016.1234680

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Are bisphenol A (BPA) and BPA analogs (BPA-A) safe for male human reproductive function? The endocrine function of human testes explants [assessed by measuring testosterone and insulin-like factor 3 (INSL3)] was impacted by exposure of the human adult testis explants to BPA/BPA-A. The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption. Adult human testis explants in culture were exposed to BPA and the analogs bisphenol F (BPF), bisphenol S (BPS), bisphenol E (BPE), bisphenol B (BPB) and bisphenol A diglycidyl ether (BADGE) at 10(-9)-10(-5) M for 24 or 48 h. Human adult testes were obtained from prostate cancer patients who had no hormone therapy, or from multiorgan donors. After ex vivo exposure to the investigated bisphenols, the measured outcomes were related to histopathology (gross morphology and germ cell viability determined by anti-caspase three immunohistochemistry), and the levels of testosterone, INSL3 and inhibin B were measured using immunoassays. The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase). A significant dose-dependent inhibition was found between testosterone levels measured in the culture medium and concentrations of BPA (P = 0.00778 at 24 h and P = 0.0291 at 48 h), BPE (P = 0.039) and BPF (P = 0.00663). The observed BPA and BPA-A-induced inhibition of testosterone production varied according to duration of exposure and BPA/BPA-A concentrations. BPA (10(-9) M; P < 0.05), BPB (10(-9) M; P < 0.05), BPS (10(-9) and 10(-8) M; P < 0.05) and BADGE (10(-5) M; P < 0.05) increased Leydig cell INSL3 production. By contrast, BPE dose dependently inhibited INSL3 (P = 0.0372). Conversely, Sertoli cell function (inhibin B) and germ cell viability were not significantly affected by either bisphenols. N/A. Environmental compounds cannot be deliberately administered to men, justifying the use of an ex vivo approach. A relatively low number of testes samples were available for analysis (n = 3, except for testosterone secretion with n = 5). The active concentrations of BPA and BPA-A used in the study were higher than those found in human biological fluids. Under our experimental conditions, direct exposure to BPA or BPA-A can result in endocrine disturbance in the adult human testis.
ISSN: 0268-1161

hal-01578582
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578582
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578582/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578582/file/Parallel%20assessment%20of%20the%20effects%20of%20bisphenol%20A_accepted.pdf
DOI : 10.1093/humrep/dex093

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Predictive toxicology aims at developing methodologies to relate the results obtained from in vitro experiments to in vivo exposure. In the case of polycyclic aromatic hydrocarbons (PAHs), a substantial amount of knowledge on effects and modes of action has been recently obtained from in vitro studies of gene expression. In the current study, we built a physiologically based toxicokinetic (PBTK) model to relate in vivo and in vitro gene expression in case of exposure to benzo(a)pyrene (BaP), a referent PAH. This model was calibrated with two toxicokinetic datasets obtained on rats exposed either through intratracheal instillation or through intravenous administration and on an in vitro degradation study. A good agreement was obtained between the model's predictions and the concentrations measured in target organs, such as liver and lungs. Our model was able to relate correctly the gene expression for two genes targeted by PAHs, measured in vitro on primary human macrophages and in vivo in rat macrophages after exposure to BaP. Combining in vitro studies and PBTK modeling is promising for PAH risk assessment, especially for mixtures which are more efficiently studied in vitro than in vivo.
Toxicology Letters

hal-00873317
https://hal.archives-ouvertes.fr/hal-00873317
https://hal.archives-ouvertes.fr/hal-00873317/document
DOI : 10.1016/j.toxlet.2010.11.017
PUBMED : 21134426

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Coral reefs are among the most species-rich and threatened ecosystems on Earth, yet the extent to which human stressors determine species occurrences, compared with biogeography or environmental conditions, remains largely unknown. With ever-increasing human-mediated disturbances on these ecosystems, an important question is not only how many species can inhabit local communities, but also which biological traits determine species that can persist (or not) above particular disturbance thresholds. Here we show that human pressure and seasonal climate variability are disproportionately and negatively associated with the occurrence of large-bodied and geographically small-ranging fishes within local coral reef communities. These species are 67% less likely to occur where human impact and temperature seasonality exceed critical thresholds, such as in the marine biodiversity hotspot: the Coral Triangle. Our results identify the most sensitive species and critical thresholds of human and climatic stressors, providing opportunity for targeted conservation intervention to prevent local extinctions.
ISSN: 2041-1723

hal-01282870
https://hal-univ-perp.archives-ouvertes.fr/hal-01282870
https://hal-univ-perp.archives-ouvertes.fr/hal-01282870/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01282870/file/ncomms10491.pdf
DOI : 10.1038/ncomms10491

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Purpose The purpose of this review was to examine the comprehensively accumulated data regarding potential therapeutic aspects of exogenous administration of interleukin 33 (IL-33) or its antagonists in allergic, cancerous, infectious, and inflammatory diseases. Methods A selected review was undertaken of publications that examined the protective and exacerbating effects of IL-33 or its inhibitors in different diseases. Mechanisms of action are summarized to examine the putative role of IL-33 in various diseases. Findings IL-33 promoted antibacterial, antiviral, anti-inflammatory, and vaccine adjuvant functions. However, in TH2-biased respiratory, allergic, parasitic, and inflammatory conditions, IL-33 exhibited disease-sensitizing effects. The alarmin cytokine IL-33 induced protective effects in diseases via recruitment of regulatory T cells; antiviral CD8+ cells, natural killer cells, γδ T cells, and nuocytes; antibacterial and antifungal neutrophils or macrophages; vaccine-associated B/T cells; and inhibition of nuclear factor–κB–mediated gene transcription. In contrast, IL-33 exacerbated the disease process by increasing TH2 cytokines, IgE and eosinophilic immune responses, and inhibition of leukocyte recruitment in various diseases. Implications The protective or exacerbated aspects of use of IL-33 or its inhibitors are dependent on the type of infection or inflammatory condition, duration of disease (acute or chronic), organ involved, cytokine microenvironment, dose or kinetics of IL-33, and genetic predisposition. The alarmin cytokine IL-33 acts at cellular, molecular, and transcriptional levels to mediate pluripotent functions in various diseases and has potential therapeutic value to mitigate the disease process
ISSN: 0149-2918

hal-01295637
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01295637
PUBMED : 26992663
DOI : 10.1016/j.clinthera.2016.02.021

Éditeur(s) : HAL CCSD American Society for Biochemistry and Molecular Biology
Résumé : International audience
Chronic low grade inflammation is closely linked to obesity-associated insulin resistance. To examine how administration of the anti-inflammatory compound indomethacin, a general cyclooxygenase inhibitor, affected obesity development and insulin sensitivity, we fed obesity-prone male C57BL/6J mice a high fat/high sucrose (HF/HS) diet or a regular diet supplemented or not with indomethacin (±INDO) for 7 weeks. Development of obesity, insulin resistance, and glucose intolerance was monitored, and the effect of indomethacin on glucose-stimulated insulin secretion (GSIS) was measured in vivo and in vitro using MIN6 β-cells. We found that supplementation with indomethacin prevented HF/HS-induced obesity and diet-induced changes in systemic insulin sensitivity. Thus, HF/HS+INDO-fed mice remained insulin-sensitive. However, mice fed HF/HS+INDO exhibited pronounced glucose intolerance. Hepatic glucose output was significantly increased. Indomethacin had no effect on adipose tissue mass, glucose tolerance, or GSIS when included in a regular diet. Indomethacin administration to obese mice did not reduce adipose tissue mass, and the compensatory increase in GSIS observed in obese mice was not affected by treatment with indomethacin. We demonstrate that indomethacin did not inhibit GSIS per se, but activation of GPR40 in the presence of indomethacin inhibited glucose-dependent insulin secretion in MIN6 cells. We conclude that constitutive high hepatic glucose output combined with impaired GSIS in response to activation of GPR40-dependent signaling in the HF/HS+INDO-fed mice contributed to the impaired glucose clearance during a glucose challenge and that the resulting lower levels of plasma insulin prevented the obesogenic action of the HF/HS diet.
ISSN: 0021-9258

hal-01074835
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01074835
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01074835/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01074835/file/JBC-2013-525220v2-Kristiansen-POSTPRINT.pdf
DOI : 10.1074/jbc.M113.525220

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The deep structure and deformation mechanisms of the Longmen Shan thrust belt (Sichuan, China), at the eastern border of the Tibetan plateau, were largely debated after the devastating Mw 7.9 Wenchuan earthquake (2008). Recent geophysical studies and field investigations have been focused on the active motion of the major Beichuan fault, which ruptured during the earthquake. However, the total exhumation across the fault still remains unclear. In the hanging wall of the Beichuan fault, the South China block is exhumed in the Pengguan massif. Close to the Beichuan fault, the rocks of the Pengguan massif underwent greenschist facies metamorphism associated with brittle-ductile deformation. No metamorphism is observed in the footwall of the fault. In this study, we characterize and date the metamorphic history recorded in the hanging wall of the Beichuan fault in order to constrain the depth and timing of exhumation of the rocks of the Pengguan massif along the fault. A high-resolution petrological approach involving chemical analyses and X-ray maps was used to analyze the micrometric metamorphic minerals. The P-T conditions of the greenschist facies metamorphic event were estimated by an inverse multi-equilibrium thermodynamic approach. The results, 280 ± 30 °C and 7 ± 1 kbar, suggest that the rocks of the Pengguan massif were exhumed from ca. 20 km depth. Our results underline the importance of the thrusting component in the long-term behavior of the Beichuan fault and provide a minimal depth at which the fault is rooted. In situ laser ablation 40Ar/39Ar dating of metamorphic white mica revealed that the greenschist overprint occurred at 135–140 Ma.The Pengguan massif was therefore partially thrusted along the Beichuan fault during the Lower Cretaceous, long before the Eocene-Miocene exhumation phase which is well-constrained by low-temperature thermochronology. Our results provide the first independent depth information for the exhumation history of the Pengguan massif and reveal a previously undocumented Lower Cretaceous tectonic event that marks the onset of the thick-skinned deformation in the external domain of the Longmen Shan (East of the Wenchuan Fault).
ISSN: 0743-9547

hal-01685556
https://hal.archives-ouvertes.fr/hal-01685556
DOI : 10.1016/j.jseaes.2017.04.003

Éditeur(s) : HAL CCSD
Résumé : This paper develops a two-way director-firm fixed effect model to study the relationship between independent directors’ individual heterogeneity and firm operating performance, using French data. This strategy allows considering and differentiating in a unified empirical framework mechanisms related to board functioning and mechanisms related to director selection. We first show that the independence status, netted out unobservable individual heterogeneity, is negatively related to performance. This result suggests that independent board members experience a strong informational gap that outweighs other monitoring benefits. However, we show that industry-specific expertise as well as informal connections inside the boardroom may help to bridge this gap. Second, we provide evidence that independent directors have higher intrinsic ability as compared to affiliated board members, consistent with a reputation-based selection process.
https://hal.archives-ouvertes.fr/hal-01060211

hal-01060211
https://hal.archives-ouvertes.fr/hal-01060211
https://hal.archives-ouvertes.fr/hal-01060211v2/document
https://hal.archives-ouvertes.fr/hal-01060211/file/cahier%202014-29.pdf

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
The aim of this article is to propose the basis for an open reflection on the sources of colonization through the literary approach proposed by Ngugi. In this context, it has been repetitively noted that the relations between Colonized and Colonizer (Memmi) are tenacious in our nature and everyday ways of thinking. And, contradictorily, the term "colonization" seems to evoke the days of yore, already accomplished, in our minds - one of the closed chapters in history - while the colonial-type armed conflicts and the process of recolonization have burst out again by the beginning of XXI century. Conquering the African resources, then to chase with all haste - using many stratagems - the least conciliatory leaders! The colonization is a process of the politico-economic exploitation that requires a mind control, of both the colonized and the colonizers.
L’objectif de cet article est de proposer les bases d’une réflexion ouverte sur les ressorts de la colonisation à travers la démarche littéraire proposée par Ngugi. Dans le prolongement de sa réflexion, il s’agit de rappeler que les rapports colonisé-colonisateur (Memmi) sont fortement ancrés dans nos logiques et raisonnements ordinaires du quotidien. Et, paradoxalement, alors que le terme de colonisation semble évoquer dans nos consciences un lointain passé, révolu – l’un des dossiers clos de l’histoire -, les guerres de type colonial et les processus de recolonialisation se précipitent en ce début de XXIème siècle. Haro sur les ressources du continent africain et qu’on chasse au plus vite -sous moult habillages- les dirigeants les moins conciliants! La colonisation est un processus d’exploitation politico-économique qui nécessite de contrôler les esprits, du colonisé comme du colonisateur.
ISSN: 1779-0980

Droits : http://creativecommons.org/licenses/by-nc/
hal-01368530
https://hal.univ-antilles.fr/hal-01368530
https://hal.univ-antilles.fr/hal-01368530/document
https://hal.univ-antilles.fr/hal-01368530/file/osez-decoloniser-l-esprit-rencontre-autour-de-l-ouvre-de-ngugi-wa-thiong-o.pdf

Éditeur(s) : HAL CCSD Taylor & Francis
Résumé : International audience
INTRODUCTION: Membrane drug transporters are well recognized as important contributing factors to pharmacokinetics, notably involved in drug-drug interactions. Besides drugs, environmental chemicals, to which humans are commonly exposed, are also substrates, inhibitors or inducers of drug transporters, which may have notable consequences toward toxicokinetics, toxicity and pharmacokinetics. AREA COVERED: This review summarizes key data about the interactions of main environmental contaminants with drug transporters, including the nature of drug transporters involved in contaminant transport, or inhibited or induced by these chemicals. Implications for toxicokinetics and toxicity of pollutants and pharmacokinetics of drugs administrated to pollutant-exposed humans are also discussed. EXPERT OPINION: Although various structurally unrelated environmental chemicals have been already demonstrated to interact with drug transporters, further in vitro and in vivo studies are probably required to characterize pollutant-transporter interplays in a more extensive and accurate way. Data obtained should be next confronted with known exposure levels of humans to pollutants, with the aim to fully determine the relevance of environmental contaminant-transporter interactions in terms of toxicokinetics, toxicity and putative pollutant-drug interactions.
ISSN: 1742-5255

inserm-00872876
http://www.hal.inserm.fr/inserm-00872876
DOI : 10.1517/17425255.2012.637918
PUBMED : 22176607

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
Political declarations and manuals to combat poverty occur while poverty is sustainable within our society. Then, economic and political leaders consider tourism as a tool for poverty reduction. Policies that judiciously use tourism must allow a catch-up in favor of the poorest.The article emphasizes the complexity of tourism and the need to take into account the tourism project in its entirety. The host territory is the support for tourist consumption which require specific improvements. But the distribution of revenues from tourism, the international movement and the final distribution of the profits must be considered across all local, national and international actors involved in the field of tourism.
Les déclarations politiques et les modes d’emploi destinés à combattre la pauvreté se succèdent tandis que la pauvreté s’inscrit durablement dans notre société. Désormais, les leaders politiques et économiques du moment considèrent le tourisme comme un outil privilégié pour réduire la pauvreté. Des politiques touristiques judicieuses doivent permettre un rattrapage économique en faveur des plus pauvres.L’article insiste sur la complexité du tourisme et la nécessité de prendre en compte le projet touristique dans sa globalité. Le territoire d’accueil est le support de consommations touristiques qui nécessitent des aménagements spécifiques. Mais la répartition des revenus du tourisme, la circulation internationale et la distribution finale des bénéfices doivent être considérées à l’échelle de tous les acteurs locaux, nationaux et internationaux qui interviennent dans le champ du tourisme.
ISSN: 1779-0980

Droits : http://creativecommons.org/licenses/by-nc/
hal-01368478
https://hal.univ-antilles.fr/hal-01368478
https://hal.univ-antilles.fr/hal-01368478/document
https://hal.univ-antilles.fr/hal-01368478/file/lorsque-le-tourisme-se-preoccupe-de-la-pauvrete.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
To study the associations between occupation, industry and prostate cancer risk in Guadeloupe, a high incidence area. Incident cases of prostate cancer (707 cases) and 722 population controls were included. Information on lifetime occupational history and other potential risk factors was collected by interview. Logistic regression was used to estimate adjusted odds-ratios (OR) and their 95% confidence intervals (CI). A significantly decreased risk was observed in farmers (OR=0.5; CI 0.4-0.7), whereas marginally elevated ORs were found for farm workers, especially in sugarcane and banana farming. Banana plantation workers had been exposed to chlordecone, an estrogenic insecticide previously found to be associated with prostate cancer risk in this population. Significantly increased risks of prostate cancer were found in stock clerks (OR=2.7; CI 1.0-7.2), fishermen (OR=2.0; CI 1.0-4.0), mail distribution clerks (OR=7.7; CI 1.7-34.4) and electricians employed for more than 20 years (OR=4.0; CI 1.0-15.8), as well as in public administration (OR=1.8; CI 1.2-2.9), retail trade (OR=2.6; CI 1.1-6.0) and manufacture of food products (OR=2.0; CI 1.1-3.9), particularly sugar (OR=13.2; IC 1.6-108). Non-significantly elevated ORs were also seen for construction workers and transport equipment operators. Although the overall findings suggest that occupational factors have only a limited role in prostate cancer aetiology, elevated risks of prostate cancer were found in several occupations or industries. Exposure to pesticides, solvents, traffic-related air pollution, low physical activity, whole-body vibration may explain some of these increased risks.
Challenges for Occupational Epidemiology in the 21st Century EPICOH 2014
Chicago, United States

hal-01118558
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118558
DOI : 10.1136/oemed-2014-102362.312
PUBMED : 25018167

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
ISSN: 1779-0980

hal-01624741
https://hal.archives-ouvertes.fr/hal-01624741
DOI : 10.4000/etudescaribeennes.381

Éditeur(s) : HAL CCSD Universites de L'ouest
Résumé : International audience
Lors du dernier contrat de plan Etat-Région, le Conseil régional de Midi-Pyrénées a opté pour une procédure originale avec la mise en place des contrats de développement reposant sur une nouvelle dimension territoriale: le "terroir".L'aménagement actuel de l'espace régional s'organise autour de trois démarches complémentaires donnant lieu à des contrats spécifiques en fonction des types de territoires. Le premier voler concerne la métropole toulousaine qui fait l'object d'une contractualisation spécifique. Viennent ensuite les contrats d'agglomération qui concernent les villes moyennes de la région, c'est-à-dire les préfectures des différents départements et quelques villes secondaires. Enfin, pour soutenir l'aménagement des campagnes et le développement de ces territoires, la Région met en place ces fameux contrats de terroirs.
ISSN: 0029-182X

hal-01406645
https://hal.archives-ouvertes.fr/hal-01406645
https://hal.archives-ouvertes.fr/hal-01406645/document
https://hal.archives-ouvertes.fr/hal-01406645/file/1999%20Des%20contrats%20de%20terroirs%20pour%20les%20Pays%20de%20la%20Gascogne%20gersoise.pdf

Éditeur(s) : HAL CCSD European Geosciences Union
Résumé : International audience
The exchanges of carbon, water and energy between the atmosphere and the Amazon basin have global implications for the current and future climate. Here, the global atmospheric inversion system of the Monitoring of Atmospheric Composition and Climate (MACC) service is used to study the seasonal and interannual variations of biogenic CO 2 fluxes in Amazonia during the period 2002–2010. The system assimilated surface measurements of atmospheric CO 2 mole fractions made at more than 100 sites over the globe into an atmospheric transport model. The present study adds measurements from four surface stations located in tropical South America, a region poorly covered by CO 2 observations. The estimates of net ecosystem exchange (NEE) optimized by the inversion are compared to an independent estimate of NEE upscaled from eddy-covariance flux measurements in Amazonia. They are also qualitatively evaluated against reports on the seasonal and interannual variations of the land sink in South America from the scientific literature. We attempt at assessing the impact on NEE of the strong droughts in 2005 and 2010 (due to severe and longer-than-usual dry seasons) and the extreme rainfall conditions registered in 2009. The spatial variations of the seasonal and in-terannual variability of optimized NEE are also investigated. While the inversion supports the assumption of strong spatial heterogeneity of these variations, the results reveal critical limitations of the coarse-resolution transport model, the surface observation network in South America during the recent years and the present knowledge of modelling uncertainties in South America that prevent our inversion from capturing the seasonal patterns of fluxes across Amazonia. However, some patterns from the inversion seem consistent with the anomaly of moisture conditions in 2009.
ISSN: 1680-7316

hal-01557375
https://hal.univ-lorraine.fr/hal-01557375
https://hal.univ-lorraine.fr/hal-01557375/document
https://hal.univ-lorraine.fr/hal-01557375/file/acp-15-8423-2015.pdf
DOI : 10.5194/acp-15-8423-2015-supplement

Éditeur(s) : HAL CCSD
Résumé : International audience
INTRODUCTION: Alpha-1 antitrypsin, secreted by the liver, inhibits neutrophil elastase. Its deficiency favours the development of emphysema. Restoring a "protective" serum level in deficient patients should make it possible to inhibit the development of emphysema. STATE OF THE ART: Human plasma-derived alpha-1 antitrypsin is a blood-derived drug sold in France under the name Alfalastin(®). The recommended posology is an I.V. administration of 60mg/kg once a week. Human plasma-derived alpha-1 antitrypsin restores anti-elastase protection in the lower lung and prevents experimental emphysema induced by the elastasis of human neutrophils in hamster. The low number of patients with alpha-1 antitrypsin deficiency is one of the difficulties to perform sufficiently powerful randomised studies. However, randomised studies have reported the efficacy of human plasma-derived alpha-1 antitrypsin perfusions on mortality, FEV1 decline and the frequency of exacerbations. Randomised control trials have demonstrated the efficacy of human plasma-derived alpha-1 antitrypsin perfusions on the loss of lung density assessed by CT scan. CONCLUSION: Augmentation therapy is simple in its conception and implementation, but it is expensive. However, there are currently no other solutions.
Revue Des Maladies Respiratoires

hal-01146841
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146841
DOI : 10.1016/j.rmr.2014.10.001
PUBMED : 25908241

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
Develop tourism as a tool in the fight against poverty requires first to agree on the meaning of the word poverty and to clarify the political intentions of the project. Reflection on the reduction of poverty through the tourism can be synthesized in three steps: first, the beneficial effects of runoff from tourist revenues in host societies, then the collateral damage resulting from tourism and, finally, to define the conditions necessary to integrate positively tourism project in the host territories.In the end, it is indispensable to develop a proactive policy, because the poorest will not benefit from famous income runoff. Taking into account complex and contradictory impact of international tourism (including inflation, revenue leakage, deconstruction accelerated of local societies), it is necessary to include it in a sustained and coherent territorial project by local communities to identify real benefits.
Concevoir le tourisme comme un outil de lutte contre la pauvreté nécessite en premier lieu de s’entendre sur le sens du mot pauvreté et de clarifier les intentions politiques d’un tel projet. La réflexion sur la réduction de la pauvreté grâce au tourisme peut être synthétisée en trois temps : tout d’abord, les effets bénéfiques du ruissellement des revenus touristiques dans les sociétés d’accueil, ensuite les dommages collatéraux qui résultent du tourisme et, finalement, définir les conditions nécessaires pour intégrer favorablement le projet touristique dans les territoires hôtes. Au final, il apparaît indispensable de développer une politique volontariste, car le fameux ruissellement de revenus ne va pas naturellement profiter aux plus démunis. Compte tenu des impacts complexes et contradictoires du tourisme international (notamment en matière d’inflation, de fuites des revenus, de déstructuration accélérée des sociétés locales), il faut l’inscrire dans un projet d’un territorial cohérent et soutenu par les communautés locales afin de dégager de réels bénéfices.
ISSN: 1779-0980

Droits : http://creativecommons.org/licenses/by-nc/
hal-01368491
https://hal.univ-antilles.fr/hal-01368491
https://hal.univ-antilles.fr/hal-01368491/document
https://hal.univ-antilles.fr/hal-01368491/file/tourisme-et-lutte-contre-la-pauvrete-opportunites-et-defis.pdf
DOI : 10.4000/etudescaribeennes.6601

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
The Caribbean Sea is emblematic of the cruise, it is known for its international routes, scenic postcards touting the charms of the region. The analysis of the cruise industry will highlight some limits and contradictions of current development patterns. The product "cruise" has evolved considerably. It’s now the cruise ship itself (temple of consumption and enclave floating) that became the object of the Cruise, the “Destination” of the cruise line.The cruise is part of mass tourism. It’s characterized by its huge boats, rationalization and cost optimization in the context of a market increasingly globalized capital. All data that must be analyzed to understand recent developments in the cruise and repeated challenges to the host territories.
El Mar Caribe es un emblema de la travesía. Esta conocido por sus rutas internacionales, postales escénicas explicando en detalle los encantos de la región. El análisis de la industria de los cruceros pondrán de relieve algunos límites y contradicciones de los patrones actuales de desarrollo. El producto "crucero" ha evolucionado considerablemente. Ahora es el crucero en sí (el templo del consumo y el enclave flotante) que se convirtió en el objeto del Crucero, el Destino "de la línea de cruceros. El crucero es parte del turismo de masas. Se caracteriza por sus grandes barcos, la racionalización y optimización de costes en el contexto de un mercado de capitales cada vez más globalizado. Todos los datos que se deben analizar para comprender la evolución reciente en el crucero y constantes desafíos a los territorios de acogida.
La mer des Caraïbes est un espace emblématique de la croisière. Au-delà de la réputation mondiale de ses destinations, des cartes postales qui vantent les charmes de la région, l’analyse de l’industrie de la croisière permet de souligner certaines limites et contradictions des modalités de développement actuelles. Le produit « croisière » a considérablement évolué : désormais c’est le paquebot en lui-même (temple de la consommation et enclave flottante) qui est devenu la destination du croisiériste. Ouverture au tourisme de masse, gigantisme des bateaux, rationalisation et optimisation des coûts dans le cadre d’un marché de plus en plus globalisé et capitalistique sont autant de données qui doivent être analysées pour comprendre l’évolution récente de la croisière et les défis renouvelés pour les territoires d’accueil.
ISSN: 1779-0980

hal-01624772
https://hal.archives-ouvertes.fr/hal-01624772
DOI : 10.4000/etudescaribeennes.3843

Éditeur(s) : [S.l.] : Ateliers Printory
Description : Description vivante et réaliste des moeurs, coutumes et habitudes du peuple martiniquais, de la découverte de leur île aux années 30
Siècle(s) traité(s) : 20
Droits : Domaine public
Provenance : Ville de Pointe-à-Pitre. Réseau des bibliothèques
Permalien : http://www.manioc.org/patrimon/PAP11048
PAP11048