Éditeur(s) : HAL CCSD WB Saunders
Résumé : International audience
: The apicomplexan parasite Toxoplasma gondii was discovered a little over one hundred years ago and was soon recognized as a pathogen responsible for congenital infection. But detailed understanding of its epidemiology emerged only after 1970 with the discovery of its life cycle. In the last ten years, high resolution molecular tools have allowed the characterization of various strain types with different virulence patterns, and current studies are exploring the distribution of these different genotypes. In parallel, sophisticated diagnostic tools have been developed and awareness of disease burden has led some European countries with high prevalence rates to implement screening of pregnant women. In this article, the screening options and therapies used to prevent congenital toxoplasmosis are dissected in the light of recent data from cohort studies and other epidemiological data.
ISSN: 0163-4453

hal-00875492
https://hal.archives-ouvertes.fr/hal-00875492
https://hal.archives-ouvertes.fr/hal-00875492/document
https://hal.archives-ouvertes.fr/hal-00875492/file/Robert-Gangneux_-_It_is_not_only_the_cat_that_did_it_-_how_to_prevent_and_treat_congenital_toxoplasmosis_HAL.d.pdf
DOI : 10.1016/j.jinf.2013.09.023

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Zebrafish, Danio rerio, is increasingly used as an animal model to study the effects of pharmaceuticals and environmental estrogens. As most of these estrogens have only been tested on human estrogen receptors (ERs), it is necessary to measure their effects on zebrafish ERs. In humans there are two distinct nuclear ERs (hERα and hERβ), whereas the zebrafish genome encodes three ERs, zfERα and two zfERβs (zfERβ1 and zfERβ2). In this study, we established HeLa-based reporter cell lines stably expressing each of the three zfERs. We first reported that estrogens more efficiently activate the zfERs at 28°C as compared to 37°C, thus reflecting the physiological temperature of zebrafish in wildlife. We then showed significant differences in the ability of agonist and antagonist estrogens to modulate activation of the three zfER isotypes in comparison to hERs. Environmental compounds (bisphenol A, alkylphenols, mycoestrogens) which are hER panagonists and hERβ selective agonists displayed greater potency for zfERα as compared to zfERβs. Among hERα selective synthetic agonists, PPT did not activate zfERα while 16α-LE2 was the most zfERα selective compound. Altogether, these results confirm that all hER ligands control in a similar manner the transcriptional activity of zfERs although significant differences in selectivity were observed among subtypes. The zfER subtype selective ligands that we identified thus represent new valuable tools to dissect the physiological roles of the different zfERs. Finally, our work also points out that care has to be taken in transposing the results obtained using the zebrafish as a model for human physiopathology.
Toxicology and Applied Pharmacology

hal-01063914
https://hal.archives-ouvertes.fr/hal-01063914
DOI : 10.1016/j.taap.2014.07.020

Éditeur(s) : HAL CCSD
Résumé : International audience
Home health care workers interventions have been implemented in western countries to improve health status of patients with respiratory diseases especially asthma and allergic illnesses. Twenty-six controlled studies dealing with prevention and control of these diseases through home environmental interventions were reviewed. After a comprehensive description of the characteristics of these studies, the effectiveness of each intervention was then evaluated in terms of participants' compliance with the intervention program, improvement of quality of the indoor environment, and finally improvement of health outcomes, in detailed tables. Limitations and biases of the studies are also discussed. Overall, this review aims at giving a toolbox for home health care workers to target the most appropriate measures to improve health status of the patient depending on his and/or her environment and disease. Only a case-by-case approach with achievable measures will warrant the efficacy of home interventions. This review will also provide to the research community a tool to better identify targets to focus in future evaluation studies of home health care workers action.
Journal of allergy and clinical immunology. In practice

hal-01477202
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477202
DOI : 10.1016/j.jaip.2016.07.011
PUBMED : 27665387

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : National audience
OBJECTIVES: Medical tools to determine the imminence of unplanned out-of-hospital birth have not been validated. The main goal of this study was to analyze assessments of the imminence of these deliveries, by methods such as the Manilas score and the need to push. PATIENTS AND METHODS: All calls made to the Emergency Medical Aid Service in Guadeloupe concerning risks of unplanned delivery between January 1st and June 30th 2011 were reviewed retrospectively, and 69 of the 85 cases cared for by the hospital mobile emergency unit were included. RESULTS: Risks of unplanned out-of-hospital deliveries represented 1.9% of the calls during the study period. The Malinas score was used for dispatching in only 13% and was not used for intervention in any case. It was estimated that the need-to-push feeling was used for 58% (dispatching) and 54.5% (intervention) of patients. Its sensitivity, specificity and predictive values were higher than those of the Malinas score in dispatching and substantially higher in intervention. CONCLUSION: These results argue for the development of tools for estimating the imminence of unplanned delivery. Such tools should be applicable in extra-hospital emergency situations to ensure their use in practice.
ISSN: 0368-2315

hal-01063667
https://hal.archives-ouvertes.fr/hal-01063667
DOI : 10.1016/j.jgyn.2013.01.009
PUBMED : 23490410

Éditeur(s) : HAL CCSD
Résumé : International audience
Estrogens and progestins are widely used in combination in human medicine and both are present in aquatic environment. Despite the joint exposure of aquatic wildlife to estrogens and progestins, very little information is available on their combined effects. In the present study we investigated the effect of ethinylestradiol (EE2) and Levonorgestrel (LNG), alone and in mixtures, on the expression of the brain specific ER-regulated cyp19a1b gene. For that purpose, recently established zebrafish-derived tools were used: (i) an in vitro transient reporter gene assay in a human glial cell line (U251-MG) co-transfected with zebrafish estrogen receptors (zfERs) and the luciferase gene under the control of the zebrafish cyp19a1b gene promoter and (ii) an in vivo bioassay using a transgenic zebrafish expressing GFP under the control of the zebrafish cyp19a1b gene promoter (cyp19a1b-GFP). Concentration-response relationships for single chemicals were modeled and used to design the mixture experiments following a ray design. The results from mixture experiments were analyzed to predict joint effects according to concentration addition and statistical approaches were used to characterize the potential interactions between the components of the mixtures (synergism/antagonism). We confirmed that some progestins could elicit estrogenic effects in fish brain. In mixtures, EE2 and LNG exerted additive estrogenic effects both in vitro and in vivo, suggesting that some environmental progestin could exert effects that will add to those of environmental (xeno-)estrogens. Moreover, our zebrafish specific assays are valuable tools that could be used in risk assessment for both single chemicals and their mixtures. © 2016 Elsevier Inc.
Toxicology and Applied Pharmacology

hal-01367151
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367151
DOI : 10.1016/j.taap.2016.07.023
PUBMED : 27491593

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Invasive aspergillosis is a major cause of mortality in allogeneic bone marrow transplant recipients and patients treated for blood malignancies. The diagnostic tools, treatments and preventive strategies, essentially developed for neutropaenic patients, have not been assessed in populations whose immune systems are considered to be competent. Beside the standard picture of chronic Aspergillus infection, the incidence of invasive aspergillosis is increasing in non neutropaenic patients, such as those with chronic lung diseases or systemic disease treated with long-term immunosuppressive drugs and solid organ transplant recipients. This study reviews the specific features of invasive aspergillosis in non neutropaenic subjects (NNS) and discusses the value of the diagnostic tools and treatment in this population. A better understanding of the pathophysiology and the epidemiological characteristics of invasive aspergillosis would provide a means of adapting the staging and classification of the disease for NNS. Invasive aspergillosis is under diagnosed in NNS who may already be colonised when they receive immunosuppressive treatment; this can lead to an adverse outcome in patients who are considered to be a moderate risk population.
ISSN: 0761-8425

hal-01118185
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118185
DOI : 10.1016/j.rmr.2010.01.004
PUBMED : 20965392

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Because many biological processes related to the dynamics of infectious diseases are caused by complex interactions between the environment, the host(s) and the agent(s), the necessity to address the methodological implications of this inherent complexity has recently emerged in epidemiology. Most epidemiologists now acknowledge that most human infectious diseases are likely to have complex dynamics. However, this knowledge still percolates with difficulty in their statistical "modus operandi". Indeed, for the study of complex systems, the traditional first-line statistical toolbox of epidemiologists (mainly built around the Generalized Linear Model family), despite its undeniable practicality and robustness, has structural limitations deprecating its usefulness. Three major sources of complexity neglected or not taken into account by this first-line statistical toolbox and having deep statistical implications are the multi-level organization of data, the non-linear relationships between variables and the complex interactions between variables. Three promising candidates to incorporate along with traditional tools for a new first-line statistical toolbox more suitable to apprehend these sources of complexity are the generalized linear mixed models, the generalized additive models, and the structural equation models. The aforementioned methodologies have the advantage to be generalizations of GLM models and are relatively easy to implement. Their assimilation and implementation would thus be greatly facilitated for epidemiologists. More globally, this text underlines that an improved use of other methods as such described here compared to traditional ones has to be performed to better understand the complexity challenging epidemiologists every day. This is particularly true in the field of infectious diseases for which major public health challenges will have to be addressed in the coming decades.
ISSN: 1567-1348

inserm-00872354
http://www.hal.inserm.fr/inserm-00872354
http://www.hal.inserm.fr/inserm-00872354/document
http://www.hal.inserm.fr/inserm-00872354/file/main_document.pdf
DOI : 10.1016/j.meegid.2013.09.006

Éditeur(s) : Elsevier
Résumé : Because Vibrio aestuarianus is known to cause serious infections in Pacific oyster Crassostrea gigas, a real-time PCR assay was developed targeting the dnaJ gene of this bacterium. Only V. aestuarianus strains isolated from C. gigas mortality events in different geographic areas and the reference strain tested positive, whereas no amplification products was obtained with type strains belonging to 23 other species of Vibrio. Sensitivity and reproducibility of the method were assessed using either seawater or oyster homogenate samples spiked with one V aestuarianus strain. All these samples were stored at -20 degrees C in order to mimic retrospective or grouped natural sample analysis without quantification bias due to prolonged freezing. Analysis of standard curves revealed excellent correlation values between light microscopy cell enumerations and PCR Threshold Cycle (Ct) values, and acceptable PCR reaction efficiencies for all type of samples. Quantification curves of both sample types were equivalent, with a detection level as low as 1.6 V. aestuarianus cells in the PCR reaction tube, corresponding to 1.6.10(2) cells ml(-1) and 1.6.10(2) cells mg(-1) in seawater and entire oyster samples, respectively, taking into account the dilution factor used for appropriate template DNA preparation. Comparison of PCR assay reproducibility according to the complexity of samples revealed that seawater samples gave more reproducible quantification measures than samples from oyster homogenate, with precision of measured Ct values inferior to 0.4 and 0.6 respectively at 99% confidence. Use of the real-time PCR assay allowed us to monitor V. aestuarianus load in oysters naturally infected with this pathogen. Furthermore, we were able to detect V aestuarianus in samples of seawater in which oysters had been reared and in algal cultures used for feeding oysters. Because of the rapidity and reliability of the real-time PCR assay method used in this study, just a few hours are needed compared with the two days required using the classic culture method, this technique will be particularly valuable in mollusc pathology laboratories, for monitoring the source and course of infections by V. aestuarianus in pathogenesis and epidemiologic studies, as well as for designing appropriate prophylactic control measures. (C) 2009 Elsevier B.V. All rights reserved.
Journal of Microbiological Methods (0167-7012) (Elsevier), 2009-05 , Vol. 77 , N. 2 , P. 191-197

Droits : 2009 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/2009/publication-6447.pdf
DOI:10.1016/j.mimet.2009.01.021
http://archimer.ifremer.fr/doc/00000/6447/

Éditeur(s) : Oxford Univ Press
Résumé : Biological reference points are important tools for fisheries management. Reference points are not static, butmay change when a population's environment or the population itself changes. Fisheries-induced evolution is one mechanism that can alter population characteristics, leading to "shifting" reference points by modifying the underlying biological processes or by changing the perception of a fishery system. The former causes changes in "true" reference points, whereas the latter is caused by changes in the yardsticks used to quantify a system's status. Unaccounted shifts of either kind imply that reference points gradually lose their intended meaning. This can lead to increased precaution, which is safe, but potentially costly. Shifts can also occur in more perilous directions, such that actual risks are greater than anticipated. Our qualitative analysis suggests that all commonly used reference points are susceptible to shifting through fisheries-induced evolution, including the limit and "precautionary" reference points for spawning-stock biomass, B-lim and B-pa, and the target reference point for fishing mortality, F-0.1. Our findings call for increased awareness of fisheries-induced changes and highlight the value of always basing reference points on adequately updated information, to capture all changes in the biological processes that drive fish population dynamics.
Ices Journal Of Marine Science (1054-3139) (Oxford Univ Press), 2013-07 , Vol. 70 , N. 4 , P. 707-721

Droits : 2013 International Council for the Exploration of the Sea. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com
http://archimer.ifremer.fr/doc/00151/26228/24302.pdf
DOI:10.1093/icesjms/fst077
http://archimer.ifremer.fr/doc/00151/26228/

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : During the 2003 summer monsoon, the Hi-CLIMB seismological stations deployed across the Himalayan Range detected bursts of high-frequency seismic noise that lasted several hours to days. On the basis of the cross correlation of seismic envelopes recorded at 11 stations, we show that the largest transient event on 15 August was located nearby a village partially destroyed on that day by a devastating debris flow. This consistency in both space and time suggests that high-frequency seismic noise analysis can be used to monitor debris flow generation as well as the evacuation of the sediment. A systematic study of one year of seismic noise, focusing on the detection of similar events, provides information on the spatial and temporal occurrence of mass movements at the front of the Himalayas. With a 50% probability of occurrence of a daily event, a total of 46 debris flows are seismically detected. Most of them were generated in regions of steep slopes, large gullies, and loose soils during the 2003 summer monsoon storms. These events are compared to local meteorological data to determine rainfall thresholds for slope failures, including the cumulative rainfall needed to bring the soil moisture content to failure capacity. The inferred thresholds are consistent with previous estimates deduced from soil studies as well as sediment supply investigations in the area. These results point out the potential of using seismic noise as a dedicated tool for monitoring the spatiotemporal occurrence of landslides and debris flows on a regional scale.
ISSN: 0148-0227

hal-00464177
https://hal.archives-ouvertes.fr/hal-00464177
DOI : 10.1029/2008JF001198

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide a unified interface to biomedical databases that are distributed worldwide. The portal provides access to numerous database projects supported by 30 scientific organizations. It includes over 800 different biological datasets spanning genomics, proteomics, model organisms, cancer data, ontology information and more. All resources available through the portal are independently administered and funded by their host organizations. The BioMart data federation technology provides a unified interface to all the available data. The latest version of the portal comes with many new databases that have been created by our ever-growing community. It also comes with better support and extensibility for data analysis and visualization tools. A new addition to our toolbox, the enrichment analysis tool is now accessible through graphical and web service interface. The BioMart community portal averages over one million requests per day. Building on this level of service and the wealth of information that has become available, the BioMart Community Portal has introduced a new, more scalable and cheaper alternative to the large data stores maintained by specialized organizations.
ISSN: 0305-1048

hal-01146849
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146849
DOI : 10.1093/nar/gkv350
PUBMED : 25897122

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : On the basis of an existing multiparameter borehole fluid sensor(p, T Cw, pH, Eh), a new downhole tool designed for 200 bars and 75 degrees C was developed to measure the spontaneous electrical potential in situ with great precision (better than a mu V). To this end, the new sensor is based on the use of unpolarizable Pb/PbCl2 electrodes either at the surface or downhole. In situ testing has demonstrated a capacity to identify several subsurface sources of natural electrical potential such as diffusion ones (membrane potential in the presence of clays, Fickian processes due to pore fluid salinity gradients), or else the electrokinetic mechanisms with gradients in pore fluid pressure. As a consequence, Multi-Sensors Electrical Tool (MuSET) might be used as an "electrical flow meter" sensitive to both horizontal and vertical fluid flow in a vertical borehole.
ISSN: 1631-0713

hal-00445251
https://hal.archives-ouvertes.fr/hal-00445251
DOI : 10.1016/j.crte.2009.07.009

Éditeur(s) : HAL CCSD Geological Society of America
Résumé : International audience
Lakes are major depositional systems for which the related depositional processes have long been considered relatively simple. Breaking this statement, this study presents a detailed analysis of deposits in Lake Saint-Jean, the third largest natural lake in Québec. In addition to postglacial deltaic and coastal depositional systems fringing the lake, current-controlled features such as a large subaqueous prograding wedge and three sediment drifts have been identifi ed in its central portion based on two-dimensional (2-D) acoustic high-resolution subbottom profiles. The large subaqueous prograding wedge is a 4-km-long and up to 15-m-thick heterolithic shelf-like construction in the southeastern part of the lake. The three sediment drifts are 0.1–0.5-km-long and 2–5-mthick mud mounds distributed on the lake floor in the central portion of the lake. Diatom analyses and radiocarbon dating show that the development of these current-controlled features occurred during the lacustrine phase, after the disconnection with the postglacial marine Laflamme Gulf at 8.5 cal. k.y. B.P. Depositional facies show evidence of recurrent bottom-current activity. Related deposits alternate with pelagic sedimentation stages characterized by the settling of mud and biogenic accumulations. We investigated the origin of bottom currents using a numerical simulation (SYMPHONIE, an oceanographic model), with the aim of modeling wind-induced lake-scale water circulation. Simulations suggest that the subaqueous prograding wedge and the three sediment drifts result from wind-induced bottom currents generated by storm events having wind speed greater than 10 m s–1. Such strong winds are able to significantly affect sedimentation in the central portion of Lake Saint-Jean. Theresulting wind-induced sedimentary features were integrated into a refi ned lacustrine depositional model that summarizes the evolution of a group of water bodies referred to as “wind-driven water bodies.” This study applies a new tool for lake strata characterization and highlights the potential diffi cultyin differentiating them from marine deposits in the geological record.
ISSN: 0016-7606

insu-01184724
https://hal-insu.archives-ouvertes.fr/insu-01184724
DOI : 10.1130/B31145.1

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Transport of liquid and gaseous hydrocarbons through focused fluid flow systems is a widespread process in continental margins and sedimentary basins, which is gaining increased attention in the assessment of geohazards, environment conservation, and securing fossil energy resources. Studying the abundance, distribution and drivers for this process is crucial for understanding its role in 1) the dynamics of gas hydrate accumulation and destabilization, 2) submarine slope stability and related tsunamis, 3) the plethora of chemosynthetic benthic ecosystems that develop in deep seep sites, and 4) the input of greenhouse gases (e.g. methane) into the ocean/atmosphere system, which may influence the atmospheric carbon budget and Earth's paleo- and present climate. New ocean exploration tools provide ever more data and improve our understanding of these systems. However, the subject still suffers from a lack of interdisciplinary knowledge dissemination. The ongoing international debate about the timing and the processes that control fluid expulsion in sedimentary basins is fuelled by their implications for structural and petroleum geology. Because fluids expelled at cold seeps originate at depth they represent open windows into the underlying petroleum systems and are valuable indicators for the reservoir systems. They may also help in deciphering past and predicting future climate change because worldwide release of large amounts of fluids may have an impact on the chemistry of the ocean and atmosphere.
ISSN: 0025-3227

hal-00772472
https://hal.archives-ouvertes.fr/hal-00772472
DOI : 10.1016/j.margeo.2012.10.012

Éditeur(s) : Elsevier Science Bv
Résumé : We developed a growth model for Crassostrea gigas oyster shells based on the use of in situ temporal manganese markings to calibrate natural cathodoluminescence (CL) changes in the shell hinge sections. A 30 min to 4-h exposure period with Mn2+ (90-120 mg l(-1)) was sufficient to create a detectable mark in the shells. This makes the Mn2+ markings the fastest mollusc shells marking technique to date. The natural CL from juvenile and adult shells cultured in four standard shellfish-farming locations along the English Channel and French Atlantic coasts, exhibited a seasonal pattern (maximum CL intensity occurring during summer periods, minimum CL intensity occurring during winter). Hydrobiological data recorded at Baie des Veys site allows us to attribute the seawater temperature as the main parameter controlling CL of shells. Chlorophyll a and seawater manganese concentration were not decisive in the luminescence intensity of the shells. A relationship between oyster hinge growth and the length of shells makes the umbo investigations a promising tool for oyster-farming and/or wild stock assessments. Shell growth varied at spatial and temporal scales (higher growth rates were observed during summer-autumn and lower during the winter period), depending on seawater temperature changes. Sub-monthly Mn2+ markings support the fact that shell deposition can occur under temperatures below 6 degrees C, which has to be taken into account for both shellfish production and environmental monitoring derived from chemical compositions of the shells. Finally, our results point out the efficiency of age and shell growth rate determination by CL analysis in further shellfish ecosystem researches.
Aquaculture (0044-8486) (Elsevier Science Bv), 2010-02 , Vol. 300 , N. 1-4 , P. 206-217

Droits : 2010 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/00002/11300/7912.pdf
DOI:10.1016/j.aquaculture.2009.12.018
http://archimer.ifremer.fr/doc/00002/11300/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Experimentally Assisted Molecular Modelling (EAMM) is an original approach for predicting the structure of organic micro-crystals and deducing their habit in the presence of various solvents and additives. It is applied here in the case of n-octylamino-nitrobenzoxadiazole (nOA-NBD), a fluorescent compound. This general approach is first of all described and validated by its blind application to three known and closely-related crystals. Then, the whole process is applied to predict the molecular crystal generated by n-octylamino-NBD, including the molecule conformation, its structure (cell parameters, molecular packing, X-ray powder diagrams) and its theoretical plus actual habits in the presence of a solvent (p-xylene) and two additives (acetic acid and n-dodecane). The conformation of the predicted molecule is validated by comparison with two similar molecules embedded in observable crystals. Then, the choice between two proposed structures (with the same energy and two equiprobable packings) is based on the comparison between experimental and re-computed X-ray powder diffraction diagrams, and also on the interpretation of an actual TEM image in the light of the proposed cell parameters. This choice is confirmed by the comparison between the vapour-grown face development (proposed by the BFDH or the attachment energy models) and the actual face development in a pure solvent. Finally, the actual habit deduced from comparing the crystal attachment energy with the adsorption energy of solvent or additive molecules is validated by SEM images of NBD micro-crystals in presence of the solvent alone or in presence of both additives. In conclusion, the EAMM approach appears to be a decisive tool for quickly simulating structural and habit properties of the molecular crystals, accessible or not by experimentation. Thus, a numerical selection of molecules becomes possible in view of deriving organic materials with predetermined properties, such as the fluorescence properties of the compound considered in the present study.
ISSN: 0022-0248

hal-00857894
https://hal.archives-ouvertes.fr/hal-00857894
DOI : 10.1016/j.jcrysgro.2011.07.035

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Subduction processes play a major role in plate tectonics and the subsequent geological evolution of Earth. This special issue focuses on ongoing research in subduction dynamics to a large extent (oceanic subduction, continental subduction, obduction…) for both past and active subduction zones and into mountain building processes and the early evolution of orogens. It puts together various approaches combining geophysics (imaging of subduction zones), petrology/geochemistry (metamorphic analysis of HP-UHP rocks, fluid geochemistry and magmatic signal, geochronology), seismology and geodesy (present-day evolution of subduction zones, active tectonics), structural geology (structure and evolution of mountain belts), and numerical modelling to provide a full spectrum of tools that can be used to constrain the nature and evolution of subduction processes and orogeny. Studies presented in this special issue range from the long-term (orogenic cycle) to short-term (seismic cycle).
ISSN: 0264-3707

insu-01287985
https://hal-insu.archives-ouvertes.fr/insu-01287985
https://hal-insu.archives-ouvertes.fr/insu-01287985/document
https://hal-insu.archives-ouvertes.fr/insu-01287985/file/rolland-2016.pdf
DOI : 10.1016/j.jog.2016.03.006

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Coral reef resource systems are complex adaptive social-ecological systems providing vital and valuableecosystem services for human societies such as food provision, coastal protection and recreational activities.Their sustainability is questioned in many places around the world as they experience combined effects ofmultiple chronic anthropogenic and natural drivers at local to global scales. From a management perspective,there is a crucial need to understand how the impact of these drivers cascade through the social-ecologicalsystem components. This study develops a transdisciplinary and participatory approach to investigating thesocial-ecological dynamics of a Polynesian coral reef coastal system. A preliminary conceptual model using theDriver-Pressure-State-Impact (DPSI) framework is first being built through participatory modeling workshops.Then, pressure-state relationships are assessed with the help of empirical datasets as a first step towards thevalidation of the DPSI model. Results shows striking social-ecological interactions with different patterns in thelagoon and in the fore reef. Local management should be: (1) less resource-focused to account more specificallyto the existing typology of actors; (2) more spatially-explicit to better distinguish management objectives andactions for the lagoon and the fore reef sub-systems; and (3) more coordinated with terrestrial agencies for acoherent land-sea connection and integration that would both (i) account for existing land-sea interactions and(ii) better reflect the Polynesian cultural heritage that considers nature from ridge to reef as a whole. Suchconceptual models of social-ecological systems are a useful tool to build exploratory scenarios to ultimatelysupport planning decision-making processes.
ISSN: 0308-597X

hal-01491968
https://hal-univ-perp.archives-ouvertes.fr/hal-01491968
DOI : 10.1016/j.marpol.2017.01.014

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
CMAS 3D, developed in MATLAB (R), is a program to support visualization of major element chemical data in three dimensions. Such projections are used to discuss correlations, metamorphic reactions and the chemical evolution of rocks, melts or minerals. It can also project data into 2D plots. The CMAS 3D interface makes it easy to use, and does not require any knowledge of Matlab (R) programming. CMAS 3D uses data compiled in a Microsoft Excel (TM) spreadsheet. Although useful for scientific research, the program is also a powerful tool for teaching.
ISSN: 0098-3004

hal-00413570
https://hal.archives-ouvertes.fr/hal-00413570
DOI : 10.1016/j.cageo.2008.07.002

Éditeur(s) : HAL CCSD
Résumé : National audience
Endometriosis is a common gynecological estrogen-dependent disorder, affecting more than 10 % of women in reproductive age. This disease results in chronic pelvic pain and infertility and is characterized by the presence of functional endometrial tissue outside of uterine cavity. To date, the diagnosis of endometriosis takes many years because of the lack of non-invasive diagnostic tools. Interestingly, "Omics" technologies demonstrated their relevance for the search, identification and characterization of potential disease biomarkers with significant achievements in many areas in the field of human health. Use a panel of Omics approaches seems to be a good way to improve our knowledge about endometriosis. Despite several studies on the subject, the potential biomarkers obtained are still not used in the clinical practice, as it calls for large-scale validation. Combined approaches based on strong interdisciplinary collaborations should improve our knowledge of endometriosis, and allow the identification of specific predictive markers, thus leading to the development of therapeutic solutions for a non-invasive and early diagnosis of this debilitating disease. Copyright © 2017 John Libbey Eurotext.
Medecine Therapeutique Medecine de la Reproduction, Gynecologie et Endocrinologie

hal-01467551
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467551
DOI : 10.1684/mte.2016.0632