Éditeur(s) : Université des Antilles Bibliothèque Universitaire
Extrait de : Les rencontres culturelles de la BU 2017-2018. Université des Antilles
Description : Co-fondateur de la compagnie Art & Fact, Laurent Troudart produit une libre adaptation chorégraphiée et dansée de La Nuit caribéenne et de Le Patron, deux pièces de l'écrivain Alfred Alexandre. Pour Laurent Troudart, "dans la littérature d'Alfred Alexandre les corps sont tiraillés, disloqués ou au contraire enfermés dans des lieux rêvés ou trop réels. L'espace et le temps se télescopent en permanence rejoignant les thèmes, très prégnants dans nos îles, de l'exil, du paradis perdu ou rêvé, de l'ici honni et de l'ailleurs fantasmé". Dans cette réalisation où sont intégrées musiques et voix off, des séquences des deux pièces sont entremêlées, juxtaposées, jusqu'à produire une oeuvre nouvelle. La représentation est suivie d'un échange avec Alfred Alexandre et Karine Bénac-Giroux, Maître de conférences en littérature à l'Université des Antilles.

Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V18171
V18171

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0003-4975

hal-01563338
http://hal.univ-brest.fr/hal-01563338
DOI : 10.1016/j.athoracsur.2016.03.093
PUBMED : 27262916

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
ISSN: 0959-8049

hal-01666517
https://hal.univ-lorraine.fr/hal-01666517
DOI : 10.1016/j.ejca.2015.11.024

Éditeur(s) : Elsevier Science Bv
Résumé : The present study focused on turbidite sedimentation in the Cilaos turbidite system, a volcaniclastic deep-sea fan recently recognized offshore La Réunion Island. A set of piston cores was collected in order to establish the stratigraphy of this fan and to examine the processes controlling the turbidite sedimentation off the Cilaos cirque (Piton des Neiges volcanic massif) over the last climatic cycle. Two main phases of turbidite activity were identified, during the ca 140–127 ka and 30–0 ka periods, coinciding with the two last glacial–interglacial transitions (i.e., Terminations II and I). In addition to changes in climate and eustatic sea-level, these periods coincide with a low effusive volcanic activity of the Piton des Neiges volcano. The high erosional rates identified in the Cilaos cirque during these intervals of both low effusive volcanic activity and enhanced rainfall level are probably the main driver of sediment supply to the deep‐sea depositional system. These new findings also highlight the important capacity of volcaniclastic turbidite systems to record rapid paleoenvironmental changes.
Sedimentary Geology (0037-0738) (Elsevier Science Bv), 2012-12 , Vol. 281 , P. 180-193

Droits : 2012 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/00105/21659/19383.pdf
DOI:10.1016/j.sedgeo.2012.09.010
http://archimer.ifremer.fr/doc/00105/21659/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We review the geodynamic evolution of the Aegea-Anatolia region and discuss strain localisation there over geological times. From Late Eocene to Present, crustal deformation in the Aegean backarc has localised progressively during slab retreat. Extension started with the formation of the Rhodope Metamorphic Core Complex (Eocene) and migrated to the Cyclades and the northern Menderes massif (Oligocene and Miocene), accommodated by crustal-scale detachments and a first series of core complexes (MCCs). Extension then localised in Western Turkey, the Corinth Rift and the external Hellenic arc after Messinian times, while the North Anatolian Fault penetrated the Aegean Sea. Through time the direction and style of extension have not changed significantly except in terms of localisation. The contributions of progressive slab retreat and tearing, basal drag, extrusion tectonics and tectonic inheritance are discussed and we favour a model (1) where slab retreat is the main driving engine, (2) successive slab tearing episodes are the main causes of this stepwise strain localisation and (3) the inherited heterogeneity of the crust is a major factor for localising detachments. The continental crust has an inherited strong heterogeneity and crustal-scale contacts such as major thrust planes act as weak zones or as zones of contrast of resistance and viscosity that can localise later deformation. The dynamics of slabs at depth and the asthenospheric flow due to slab retreat also have influence strain localisation in the upper plate. Successive slab ruptures from the Middle Miocene to the Late Miocene have isolated a narrow stripe of lithosphere, still attached to the African lithosphere below Crete. The formation of the North Anatolian Fault is partly a consequence of this evolution. The extrusion of Anatolia and the Aegean extension are partly driven from below (asthenospheric flow) and from above (extrusion of a lid of rigid crust).
ISSN: 0040-1951

insu-00715950
https://hal-insu.archives-ouvertes.fr/insu-00715950
https://hal-insu.archives-ouvertes.fr/insu-00715950/document
https://hal-insu.archives-ouvertes.fr/insu-00715950/file/Jolivet-Aegean_Tectonophysics-2012.pdf
DOI : 10.1016/j.tecto.2012.06.011

Éditeur(s) : HAL CCSD Mary Ann Liebert
Résumé : International audience
Little information is available on the molecular epidemiologic profile of HIV-1 in French Guiana, the French department with the highest HIV/AIDS incidence. To follow the evolution of HIV-1 diversity, we carried out a molecular analysis of HIV-1 isolates from 305 treatment-naive patients between 2006 and 2012. Protease and reverse-transcriptase sequences were obtained for subtype characterization, polymorphism analysis, and identification of drug resistance mutations. Of 305 HIV-1 strains, 95.1% were subtype B viruses. The overall prevalence of transmitted drug-resistance mutations (TDRMs) was 4.6% (14/305), ranging from 1.9% to 7.1% depending on the year. This study shows a low level of HIV-1 genetic diversity and a moderate prevalence of TDRMs with no evidence of an increasing trend over the study period. Nevertheless, the strong genetic polymorphism observed on both genes may be of concern for long-term treatment of people living with HIV-1 and thus deserves continuous monitoring.
ISSN: 0889-2229

pasteur-01583613
https://hal-riip.archives-ouvertes.fr/pasteur-01583613
https://hal-riip.archives-ouvertes.fr/pasteur-01583613/document
https://hal-riip.archives-ouvertes.fr/pasteur-01583613/file/2016%20Darcissac%20et%20al.%20ARHR.pdf
DOI : 10.1089/aid.2016.0048

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case-control study comprised 410 patients who had surgery for a pituitary tumour with long-term follow-up. Using pituitary magnetic resonance imaging for diagnosis of cavernous or sphenoid sinus invasion, immunocytochemistry, markers of the cell cycle (Ki-67, mitoses) and p53, tumours were classified according to size (micro, macro and giant), type (PRL, GH, FSH/LH, ACTH and TSH) and grade (grade 1a: non-invasive, 1b: non-invasive and proliferative, 2a: invasive, 2b: invasive and proliferative, and 3: metastatic). The association between patient status at 8-year follow-up and age, sex, and classification was evaluated by two multivariate analyses assessing disease- or recurrence/progression-free status. At 8 years after surgery, 195 patients were disease-free (controls) and 215 patients were not (cases). In 125 of the cases the tumours had recurred or progressed. Analyses of disease-free and recurrence/progression-free status revealed the significant prognostic value (p < 0.001; p < 0.05) of age, tumour type, and grade across all tumour types and for each tumour type. Invasive and proliferative tumours (grade 2b) had a poor prognosis with an increased probability of tumour persistence or progression of 25- or 12-fold, respectively, as compared to non-invasive tumours (grade 1a). This new, easy to use clinicopathological classification of pituitary endocrine tumours has demonstrated its prognostic worth by strongly predicting the probability of post-operative complete remission or tumour progression and so could help clinicians choose the best post-operative therapy.
ISSN: 0001-6322

hal-00875723
https://hal.archives-ouvertes.fr/hal-00875723
DOI : 10.1007/s00401-013-1084-y
PUBMED : 23400299

Éditeur(s) : Amer Assoc Advancement Science
Science (0036-8075) (Amer Assoc Advancement Science), 2013-05 , Vol. 340 , N. 6134 , P. 810-811

Droits : 2013 American Association for the Advancement of Science. All Rights Reserved.
http://archimer.ifremer.fr/doc/00139/25068/23186.pdf
DOI:10.1126/science.340.6134.810-b
http://archimer.ifremer.fr/doc/00139/25068/

Éditeur(s) : HAL CCSD
Résumé : International audience
The challenge is to implement research that can estimate the consequences ofclimate changes in terms of impact on terrestrial environments and resources.Emphasis should be placed on regions dependent on natural resources and forwhich demographic pressure is strong. Simulations obtained from climate modelprojections (using different Representative Concentration Pathways (RCPs))predict that the Mediterranean basin and its southern periphery are particularlyvulnerable to water resources and environmental impact (IPCC, AR5, 2013).An annual rainfall decrease by 30% is found for the projection period 2070-2099(IPCC, AR5, 2013) associated with a decrease in water resources by 30 to 50%(Milano, 2012). In addition, several studies using regional atmospheric modelsindicate an increase in the precipitation inter-annual variability with extremeevents and a spatial heterogeneous signature, superimposed on a decrease in thetotal precipitation amount (Giorgi and Lionello, 2008; Raible et al. 2010).Currently, regional climate projections are highly sensitive to the climate modelused. In particular, spatial resolution as well as local climate conditions seemto impact significantly on the simulations (Jacob et al. 2014).The Mediterranean region, at the interface between arid and temperate climateswith several mountainous areas, is a complex climate system affected by theinteractions between mid-latitude and sub-tropical processes. In this context,Morocco, located at the transition between a temperate climate to the North anda tropical climate to the south constitutes a key area for an impact and sensitivitystudy to global climate changes. The climate is influenced by the Atlantic Ocean,the Mediterranean Sea and the Sahara, together with a very steep orography inthe Atlas region. The precipitation distribution is therefore characterised by greatspatial variability, and exhibits a marked seasonality, a strong inter-annualvariability (Ouda et al. 2005) and in general a pronounced gradient from northto south and west to east. At a broader scale, Morocco is located on the subtropicalsubsidence path and between the Acores High and the Saharan Low (Agoussine,2003). Several studies have also identified strong links with inter-annualprecipitation variability and NAO index (Knippertz, 2003) as well as remoteclimate modes (Esper et al. 2007).Continental climate variability at a local/regional scale, if it is to be integratedin climate predictions, needs to be supported by long-term observation.Meteorological stations in Morocco provide climatic data mainly for the last40 years with only a few stations located in the mountainous region (Tramblayet al. 2012; 2013; Driouech et al. 2010). This climate database is also supportedby the IAEA network providing stations for which isotope tracers have beenapplied to daily/monthly rain and water vapour samples over 2 to 3 years between2000 and 2004. Besides the poor coverage of instrumented areas, lacustrinesystems can provide a climatic data set that offers access to short and long-termtime series of climate parameters when knowledge of modern lake water balanceis combined with lacustrine sedimentary-climate records. Lake sediment recordsideally provide high resolution climate/environmental information of the last10,000 years (Magny et al. 2013). This time interval (corresponding to theHolocene) is a key period to investigate short and long-term climate variabilityand to improve prediction in a warming climate.In this study we present an integrated approach focusing on a mountainous lake(Aguelmam Azigza). The modern lake system study is based on site monitoring(2012-2016) and available regional hydro-climatic data. These data show thatlake level changes during the instrumented period were mainly driven byprecipitation following the high inter-annual variability. These data are thencompared with accurately dated short sediment cores retrieved in the same lake.Micro-scale geochemical and sedimentological analyses of these sequencesenable us to identify various sedimentary facies that can be linked with periodsof high (low) lake levels over the past decades.
The Mediterranean Region under Climate ChangeLa méditerranée face au changement climatique

insu-01394690
https://hal-insu.archives-ouvertes.fr/insu-01394690
https://hal-insu.archives-ouvertes.fr/insu-01394690/document
https://hal-insu.archives-ouvertes.fr/insu-01394690/file/Vidaletal.2016-COP22-Chap1.pdf

Éditeur(s) : Elsevier Science Bv
Résumé : The Var turbiditic system located in the Ligurian Sea (SE France) is an intermediate mud/sand-rich system. The particularity of the Var deep-sea fan is its single channel with abrupt bends and its asymmetric and hyper-developed levee on the right hand side: the Var Sedimentary Ridge. Long-term sediment accumulation on the Var Sedimentary Ridge makes this an ideal target for studying the link between onshore climate change and deep-sea turbidite stratigraphy. This paper focuses on the establishment of the first detailed stratigraphy of the levee, which is used to analyze the timing of overbank deposition throughout the last deglaciation. Main results indicate that high variability in turbidite frequencies and deposition rates along the Var Sedimentary Ridge are determined by two main parameters: 1) the progressive decrease of the levee height controlling the ability of turbidity currents to spill out from the channel onto the levee, and 2) climatic variations affecting the drainage basin, in particular changes in glacial condition since late Last Glacial Maximum to early Holocene. Compared to other deep-water areas, this study confirms the ability of turbiditic systems to record past climatic events on millennial timescales, and underlines the influence of European deglaciation on the observed decrease in turbidite activity in the Var canyon. The presence of a very narrow continental shelf and a single, large channel-levee system makes the Var Sedimentary Ridge a unique example of climate-controlled turbiditic accumulations. (C) 2010 Elsevier B.V. All rights reserved.
Marine Geology (0025-3227) (Elsevier Science Bv), 2011-01 , Vol. 279 , N. 1-4 , P. 148-161

Droits : 2010 Elsevier Ltd All rights reserved.
http://archimer.ifremer.fr/doc/00030/14104/11370.pdf
DOI:10.1016/j.margeo.2010.10.021
http://archimer.ifremer.fr/doc/00030/14104/

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
Le premier volet du projet Cyprim vise à mieux identifier les précurseurs des cyclogenèses et des précipitations intenses en région méditerranéenne. Cet article en présente les principaux résultats. Il est question des ingrédients météorologiques à l'origine de ces systèmes, de la grande à la mésoéchelle, des causes des fortes intensités, localisations et parfois stationnarité des récipitations associées. Le coeur de l'article présente des méthodes d'identification des anomalies de tourbillon potentiel liées à l'occurrence d'événements précipitants intenses et dresse une climatologie de ces anomalies. Les perspectives d'exploitation de cette information pour améliorer la qualité des prévisions sont évoquées. ENGLISH VERSION: The first part of the CYPRIM project (Cyclogenesis and intense precipitations in the Mediterranean region) aims at a better identification of the precursor structures of cyclogenesis and heavy precipitation in the Mediterranean region. This article presents the main results. It mentions the meteorological ingredients from which these systems originate from the large to themesoscale, the reasons for large intensities, the localization and sometimes stationarity of the associated precipitations. The heart of the article shows methods for identifiying potential vorticity anomalies involved in the occurrence of heavy precipitation events and sets up a climatology of these anomalies.The perspectives of the usefulness of this information for improving forecast quality are discussed.
ISSN: 0026-1181

insu-00448250
https://hal-insu.archives-ouvertes.fr/insu-00448250
DOI : 10.4267/2042/28828

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Bone Morphogenetic Protein 9 (BMP9) has been recently found to be the physiological ligand for the activin receptor-like kinase 1 (ALK1), and to be a major circulating vascular quiescence factor. Moreover, a soluble chimeric ALK1 protein (ALK1-Fc) has recently been developed and showed powerful anti-tumor growth and anti-angiogenic effects. However, not much is known concerning BMP9. This prompted us to investigate the human endogenous sources of this cytokine and to further characterize its circulating form(s) and its function. Analysis of BMP9 expression reveals that BMP9 is produced by hepatocytes and intrahepatic biliary epithelial cells. Gel filtration analysis combined with ELISA and biological assays demonstrate that BMP9 circulates in plasma (1) as an unprocessed inactive form that can be further activated by furin a serine endoprotease, and (2) as a mature and fully active form (composed of the mature form associated with its prodomain). Analysis of BMP9 circulating levels during mouse development demonstrates that BMP9 peaks during the first 3 weeks after birth and then decreases to 2 ng/mL in adulthood. We also show that circulating BMP9 physiologically induces a constitutive Smad1/5/8 phosphorylation in endothelial cells. Taken together, our results argue for the role of BMP9 as a hepatocyte-derived factor, circulating in inactive (40%) and active (60%) forms, the latter constantly activating endothelial cells to maintain them in a resting state.
ISSN: 1420-682X

hal-00681969
https://hal.archives-ouvertes.fr/hal-00681969
DOI : 10.1007/s00018-011-0751-1
PUBMED : 21710321

Éditeur(s) : HAL CCSD
Résumé : International audience
Reports on dengue morbidity in patients with sickle cell disease (SCD) are scarce. Dengue is arthropod-borne viroses due to dengue virus (DENV) and affects populations with a high prevalence of SCD; therefore, the risk of morbidity may be increased.To determine the impact of dengue infection in SCD patients, we reviewed medical records during a vast outbreak of dengue virus serotype-2 (DENV-2) in French Guiana in 2012-2013. We identified 10 cases of laboratory-confirmed dengue infection;these were classified into A, B and C categories based on levels of severity of dengue according to World Health Organisation (WHO). The average age of SCD patients was 18.2 years. 1, 6 and 3 cases were classified as A, B and C WHO severity criteria, respectively. All patients had an important decrease in haematocrit (while one of the WHO severity criteria is the increase of haematocrit). Only one patient had decreased platelet count. Seven cases had vaso-occlusive crisis (VOC), six patients developed acute hepatitis and eight had a simultaneous bacterial infection. Six of them needed a blood transfusion. The results suggested that the WHO severity laboratory criteria of hemoconcentration and platelet counts were not helpful in themanagement of SCD patients. The morbidity was mainly caused by specific complications of SCD, especially VOC, likely facilitated by vascular endothelial damages consecutive to dengue fever, severe haemolysis, hepatitis and bacterial co-infections.
Journal of Virology and Retrovirology

Droits : info:eu-repo/semantics/OpenAccess
inserm-01419456
http://www.hal.inserm.fr/inserm-01419456
http://www.hal.inserm.fr/inserm-01419456/document
http://www.hal.inserm.fr/inserm-01419456/file/2015%2C%20Mosnier%20-%20Dengue%20infection%20in%20sickle%20cell%20patients%20in%20French%20Guiana.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Background Orodental diseases include several clinically and genetically heterogeneous disorders that can present in isolation or as part of a genetic syndrome. Due to the vast number of genes implicated in these disorders, establishing a molecular diagnosis can be challenging. We aimed to develop a targeted next-generation sequencing (NGS) assay to diagnose mutations and potentially identify novel genes mutated in this group of disorders. Methods We designed an NGS gene panel that targets 585 known and candidate genes in orodental disease. We screened a cohort of 101 unrelated patients without a molecular diagnosis referred to the Reference Centre for Oro-Dental Manifestations of Rare Diseases, Strasbourg, France, for a variety of orodental disorders including isolated and syndromic amelogenesis imperfecta (AI), isolated and syndromic selective tooth agenesis (STHAG), isolated and syndromic dentinogenesis imperfecta, isolated dentin dysplasia, otodental dysplasia and primary failure of tooth eruption. Results We discovered 21 novel pathogenic variants and identified the causative mutation in 39 unrelated patients in known genes (overall diagnostic rate: 39%). Among the largest subcohorts of patients with isolated AI (50 unrelated patients) and isolated STHAG (21 unrelated patients), we had a definitive diagnosis in 14 (27%) and 15 cases (71%), respectively. Surprisingly, COL17A1 mutations accounted for the majority of autosomal-dominant AI cases. Conclusions We have developed a novel targeted NGS assay for the efficient molecular diagnosis of a wide variety of orodental diseases. Furthermore, our panel will contribute to better understanding the contribution of these genes to orodental disease. Trial registration numbers NCT01746121 and NCT02397824
Journal of Medical Genetics

hal-01272929
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01272929
DOI : 10.1136/jmedgenet-2015-103302
PUBMED : 26502894

Éditeur(s) : HAL CCSD
Résumé :  
Improvement of wood quality related traits is currently hampered by costly chemical and technological assays and the necessity to wait until the trees are nearly mature to evaluate wood properties. The availability of a vast quantity of genomic data opens now a new avenue to identify early selection criteria based on molecular information and therefore increase selection efficiency. Association mapping is becoming a method of choice to identify QTN (quantitative trait nucleotide) that contribute to complex trait variation. The implementation of this approach requires on the one hand knowledge of the molecular mechanisms underlying trait variation and polymorphism within candidate genes, and on the other hand the availability of phenotypically well characterized genetic material. We are developing this strategy in the frame of the French maritime pine breeding program, an economically important forest tree species in the South Western Europe. About 500 trees from the breeding population were evaluated for wood physical and chemical properties through the analysis of 2,800 half-sib progenies and 1,500 clones in 8 field tests. These same trees are being genotyped at 185 SNPs obtained from the sequencing of 41 candidate genes, and an additional set of 200 eSNPs detected in 147 EST-contigs (to be used as control). Statistical association between the breeding values of the 500 trees and their respective genotypes will be tested using mixed models accounting for relatedness among individuals of the breeding population.
IUFRO-CTIA joint conference, "Adaptation, Breeding and Conservation in the Era of Forest Tree Genomics and Environmental Change"
Québec City, Canada

hal-01032075
https://hal.archives-ouvertes.fr/hal-01032075

Éditeur(s) : HAL CCSD John Libbey Eurotext
Résumé : International audience
ISSN: 1635-0421

hal-01118630
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118630
DOI : 10.1684/ers.2012.0511

Éditeur(s) : HAL CCSD American Medical Association (AMA)
Résumé : International audience
IMPORTANCE Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome. OBJECTIVE To determine whether empirical micafungin reduces invasive fungal infection (IFI)-free survival at day 28. DESIGN, SETTING, AND PARTICIPANTS Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill patients with ICU-acquired sepsis, multiple Candida colonization, multiple organ failure, exposed to broad-spectrum antibacterial agents, and enrolled between July 2012 and February 2015 in 19 French ICUs. INTERVENTIONS Empirical treatment with micafungin (100mg, once daily, for 14 days) (n = 131) vs placebo (n = 129). MAIN OUTCOMES AND MEASURES The primary end pointwas survival without proven IFI 28 days after randomization. Key secondary end points included new proven fungal infections, survival at day 28 and day 90, organ failure, serum (1-3)-beta-D-glucan level evolution, and incidence of ventilator-associated bacterial pneumonia. RESULTS Among 260 patients (mean age 63 years; 91 [35%] women), 251 (128, micafungin group; 123, placebo group) were included in the modified intent-to-treat analysis. Median values were 8 for Sequential Organ Failure Assessment (SOFA) score, 3 for number of Candida-colonized sites, and 99 pg/mL for level of (1-3)-beta-D-glucan. On day 28, there were 82 (68%) patients in the micafungin group vs 79 (60.2%) in the placebo group who were alive and IFI free (hazard ratio [HR], 1.35 [95% CI, 0.87-2.08]). Results were similar among patients with a (1-3)-beta-D-glucan level of greater than 80 pg/mL (n = 175; HR, 1.41 [95% CI, 0.85-2.33]). Day-28 IFI-free survival in patients with a high SOFA score (> 8) was not significantly different when compared between the micafungin vs placebo groups (HR, 1.69 [95% CI, 0.96-2.94]). Use of empirical micafungin decreased the rate of new invasive fungal infection in 4 of 128 patients (3%) in the micafungin group vs placebo (15/123 patients [12%]) (P =.008). CONCLUSIONS AND RELEVANCE Among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure, empirical treatment with micafungin, compared with placebo, did not increase fungal infection-free survival at day 28.
ISSN: 0098-7484

hal-01405822
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01405822
DOI : 10.1001/jama.2016.14655
PUBMED : 27706483

Éditeur(s) : Pergamon-elsevier Science Ltd
Résumé : We report rare earth element (REE) and neodymium (Nd) isotope data for the organic fraction of sediments collected from various depositional environments, i.e. rivers (n=25), estuaries (n=18), open-ocean settings (n=15), and cold seeps (n=12). Sedimentary Organic Matter (SOM) was extracted using a mixed hydrogen peroxide/nitric acid solution (20%-H2O2 – 0.02M-HNO3), after removal of carbonate and oxy-hydroxide phases with dilute hydrochloric acid (0.25M-HCl). A series of experimental tests indicate that extraction of sedimentary organic compounds using H202 may be complicated occasionally by partial dissolution of sulphide minerals and residual carbonates. However, this contamination is expected to be minor for REE because measured concentrations in H2O2 leachates are about two-orders of magnitude higher than in the above mentioned phases. The mean REE concentrations determined in the H2O2 leachates for samples from rivers, estuaries, coastal seas and open-ocean settings yield relatively similar levels, with ΣREE = 109 ± 86 ppm (mean ± s; n=58). The organic fractions leached from cold seep sediments display even higher concentration levels (285 ± 150 ppm; mean ± s; n=12). The H2O2 leachates for most sediments exhibit remarkably similar shale-normalized REE patterns, all characterized by a mid-REE enrichment compared to the other REE. This suggests that the distribution of REE in leached sedimentary organic phases is controlled primarily by biogeochemical processes, rather than by the composition of the source from which they derive (e.g. pore, river or sea- water). The Nd isotopic compositions for organic phases leached from river sediments are very similar to those for the corresponding detrital fractions. In contrast, the SOM extracted from marine sediments display εNd values that typically range between the εNd signatures for terrestrial organic matter (inferred from the analysis of the sedimentary detrital fractions) and marine organic matter (inferred from the analysis of local surface seawater). A notable exception is the case of organic matter (OM) fractions leached from cold seep sediment samples, which sometimes exhibit εNd values markedly different from both terrigenous and surface seawater signatures. This suggests that a significant fraction of organic compounds in these sediments may be derived from chemosynthetic processes, recycling pore water REE characterized by a distinct isotopic composition. Overall, our results confirm that organic matter probably plays an important role in the oceanic REE budget, through direct scavenging and remineralization within the water column. Both the high REE abundances and the shape of shale-normalized patterns for leached SOM also suggest that OM degradation in sub-surface marine sediments during early diagenesis could control, to a large extent, the distribution of REE in pore waters. Benthic fluxes of organic-bound REE could hence substantially contribute to the exchange processes between particulates and seawater that take place at ocean margins. Neodymium isotopes could provide useful information for tracing the origin (terrestrial versus marine) and geographical provenance of organic matter, with potential applications in paleoceanography. In particular, future studies should further investigate the potential of Nd isotopes in organic compounds preserved in sedimentary records for reconstructing past variations of surface ocean circulation.
Geochimica Et Cosmochimica Acta (0016-7037) (Pergamon-elsevier Science Ltd), 2014-09 , Vol. 140 , P. 177-198

Droits : 2014 Elsevier Ltd. All rights reserved.
http://archimer.ifremer.fr/doc/00191/30250/28682.pdf
DOI:10.1016/j.gca.2014.05.016
http://archimer.ifremer.fr/doc/00191/30250/

Éditeur(s) : Elsevier Science Bv
Résumé : We developed a growth model for Crassostrea gigas oyster shells based on the use of in situ temporal manganese markings to calibrate natural cathodoluminescence (CL) changes in the shell hinge sections. A 30 min to 4-h exposure period with Mn2+ (90-120 mg l(-1)) was sufficient to create a detectable mark in the shells. This makes the Mn2+ markings the fastest mollusc shells marking technique to date. The natural CL from juvenile and adult shells cultured in four standard shellfish-farming locations along the English Channel and French Atlantic coasts, exhibited a seasonal pattern (maximum CL intensity occurring during summer periods, minimum CL intensity occurring during winter). Hydrobiological data recorded at Baie des Veys site allows us to attribute the seawater temperature as the main parameter controlling CL of shells. Chlorophyll a and seawater manganese concentration were not decisive in the luminescence intensity of the shells. A relationship between oyster hinge growth and the length of shells makes the umbo investigations a promising tool for oyster-farming and/or wild stock assessments. Shell growth varied at spatial and temporal scales (higher growth rates were observed during summer-autumn and lower during the winter period), depending on seawater temperature changes. Sub-monthly Mn2+ markings support the fact that shell deposition can occur under temperatures below 6 degrees C, which has to be taken into account for both shellfish production and environmental monitoring derived from chemical compositions of the shells. Finally, our results point out the efficiency of age and shell growth rate determination by CL analysis in further shellfish ecosystem researches.
Aquaculture (0044-8486) (Elsevier Science Bv), 2010-02 , Vol. 300 , N. 1-4 , P. 206-217

Droits : 2010 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/00002/11300/7912.pdf
DOI:10.1016/j.aquaculture.2009.12.018
http://archimer.ifremer.fr/doc/00002/11300/

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : Cette communication présente les principaux résultats du projet ExtraFlo sur l'estimation des pluies et crues extrêmes. A partir d'un jeu de données conséquent de plusieurs milliers de stations, une procédure d'inter-comparaison a permis d'évaluer les performances d'une trentaine d'implémentations différentes issues de différentes combinaisons (modèle probabiliste, méthode d'estimation, cadre local / régional / mixte local et régional). Le projet ExtraFlo a permis de mettre en évidence le manque de robustesse des approches basées sur le traitement statistique d'une série de quelques dizaines d'années d'observation. Des alternatives intéressantes existent, basées sur l'exploitation des records de pluie et de débit à l'échelle d'une région, de la collecte de données historiques quand cela est possible, de méthodes de simulation basées sur le couplage d'un générateur d'averses avec un modèle hydrologique pour la transformation des pluies en débit, ou des traces morphologiques laissées par les crues anciennes.
ISSN: 0018-6368

hal-01054313
https://hal.archives-ouvertes.fr/hal-01054313
DOI : 10.1051/1hb/2014010