Extrait de : Les aventuriers et les boucaniers d'Amérique (Page 209)
Résumé : Gravure
Siècle(s) traité(s) : 17
Droits : Domaine public
Permalien : http://www.manioc.org/images/PAP110470217i1
PAP110470217i1

Extrait de : Les aventuriers et les boucaniers d'Amérique (Page 216)
Résumé : Plan
Siècle(s) traité(s) : 17
Droits : Domaine public
Permalien : http://www.manioc.org/images/PAP110470224i1
PAP110470224i1

Éditeur(s) : Paris : éditions Duchartre et Van Buggenhoudt
Extrait de : Les frères de La Coste, Flibustiers et Corsaires (p. 91)
Résumé : Homme et femme indiens caraïbes à côté d'un papayer.
Siècle(s) traité(s) : 17
Permalien : http://www.manioc.org/images/FCL18014-0113i1
FCL18014-0113i1

Éditeur(s) : Paris : éditions Duchartre et Van Buggenhoudt
Extrait de : Les frères de La Coste, Flibustiers et Corsaires (p. 85)
Résumé : Des flibustiers et des Indiens Caraibes en bord de mer.
Siècle(s) traité(s) : 17
Permalien : http://www.manioc.org/images/FCL18014-0107i1
FCL18014-0107i1

Éditeur(s) : Paris : éditions Duchartre et Van Buggenhoudt
Extrait de : Les frères de La Coste, Flibustiers et Corsaires (p. 195)
Résumé : Des esclaves travaillant une sucrerie.

Permalien : http://www.manioc.org/images/FCL18014-0219i1
FCL18014-0219i1

Éditeur(s) : HAL CCSD Impact journals
Résumé : International audience
Interleukin (IL)-33 has been recently reported to be strongly pro-fibrogenic in various models of liver disease. Our aim was to study the role of endogenous IL-33 in a diet-induced model of steatohepatitis. IL-33 deficient mice and wild type (WT) littermates received a high-fat diet (HFD), or a standard diet for 12 weeks. The HFD-induced steatohepatitis was associated with an upregulation of IL-33 transcripts and protein. An insulin tolerance test revealed lower systemic insulin sensitivity in IL33-/-HFD mice than in WT-HFD mice. Nevertheless, IL-33 deficiency did not affect the severity of liver inflammation by histological and transcriptomic analyses, nor the quantity of liver fibrosis. Livers from HFD mice had more myeloid populations, markedly fewer NKT cells and higher proportion of ST2+ Treg cells and ST2+ type 2 innate lymphoid cells (ILC2), all unaffected by IL-33 deficiency. In conclusion, deficiency of endogenous IL-33 does not affect the evolution of experimental diet-induced steatohepatitis towards liver fibrosis.
ISSN: 1949-2553

hal-01578584
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578584
DOI : 10.18632/oncotarget.18335
PUBMED : 28611297

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
We make this reply to Philippe Oliver's comments on the deformation of the Mesozoic cover of the northern Agly massif.
ISSN: 0278-7407

hal-00903419
https://hal.archives-ouvertes.fr/hal-00903419
https://hal.archives-ouvertes.fr/hal-00903419/document
https://hal.archives-ouvertes.fr/hal-00903419/file/Vauchez_et_al-2013-Tectonics.pdf
DOI : 10.1002/tect.20061

Éditeur(s) : HAL CCSD
Résumé : National audience
Les lherzolites de l’étang de Lherz, de Freychinède et de Berqué sontassociées à des métasédiments détritiques contenant des fragments dominantsde manteau et de marbres issus du démantèlement de la couverturemétamorphique mésozoïque de la Zone Nord-Pyrénéenne(ZNP).Les relations originelles entre le socle ultrabasique et ces brèches etmicrobèches ne sont pas toujours accessibles, mais on peut observeren quelques endroits des caractères de contacts sédimentaires (surfaceirrégulière, anfractuosités emplies de microbrèches, remaniement dela lherzolite serpentinisée). La matrice des brèches est invariablementconstituée de grains issus du démantèlement du manteau serpentiniséou non (Ol, CPX, OPX, spinelles, serpentines). Ce cortège ultrabasiqueest associé à des fragments de marbres souvent foliés portant déjàl’empreinte du métamorphisme HT pyrénéen. On trouve également engrande quantité de petites phyllites dont l’origine est soit détritique, soitmétamorphique, par cuisson de la brèche lors d’un stade tardif métamorphismeHT crétacé. Sur le corps de Lherz, la composition des clastes desbrèches évolue entre un pôle 100% carbonaté et un pôle 100% ultrabasique.Par endroit, les carbonates envahissent la péridotite serpentiniséequi prend alors l’aspect typique des ophicalcites. En plusieurs points,à la périphérie immédiate des corps de Lherz et de Freychinède et dansles fentes au sein des lherzolites de Berqué, affleurent les roches à saphirine(voir Monchoux, 1973) faites de lits de minéraux souvent bien triéset de microbrèches dont la composition, surprenante, associe un cortègeultrabasique à un cortège singulier de débris de métaévaporites etde métaophites (phlogopites, anthophyllites, enstatites, hornblendes,...).La mise à nu du manteau dans la ZNP au Crétacé s’accompagne doncdu démantèlement de toute la couverture métamorphique prérift, depuisle Trias jusqu’au Crétacé. Cette contrainte est intégrée dans le modèled’exhumation proposé pour cette partie de la ZNP. Ce modèle tente derendre compte également de la présence au sein du corps principal desbrèches de Lherz (vallon de Fontête Rouge) de rares fragments d’uncroûte continentale à affinité granulitique
24 ème Réunion des sciences de la Terre 2014
Pau, France

insu-01080835
https://hal-insu.archives-ouvertes.fr/insu-01080835

Éditeur(s) : HAL CCSD
Résumé : National audience
Un ensemble de données sur l’environnement géologique despéridotites de la Zone Nord-Pyrénéenne a été obtenu dans lecadre des programmes ANR Pyramid et RGF-BRGM consacrésà l’évolution géodynamique des Pyrénées. Ces données représententdes contraintes indispensables pour l’étude des processus del’exhumation du manteau, de l’amincissement de la croûte continentaleet de sa disparition complète lors de l’ouverture desbassins transtensifs albo-cénomaniens. On y trouve : (1) de nouveauxlevés géologiques de détail autour des lherzolites de Lherz-Freychinède-Vicdessos-Bestiac-Prades et d’Urdach-Les Pernes et(2) des analyses multi-méthodes des métasédiments de la couvertureprérift et du socle paléozoïque adhérent au manteau :composition des assemblages du métamorphisme HT, températuresmaximales par spectrométrie RAMAN sur la m.o., fabriquede la calcite par EBSD, inclusions fluides et isotopes stables dansles marbres et veines associées, datations U-Th-Pb in situ. Cesdonnées permettent d’estimer les conditions thermiques lors de laremontée du manteau et de sa mise à l’affleurement. Nous montronsune variabilité remarquable de l’Ouest vers l’Est.A l’Ouest, le manteau est exhumé à l’Albien sup. - Cénomanieninf. en perçant une couverture mésozoïque prérift qui n’a pas étéchauffée à plus de 250C. La croûte continentale supérieure y estréduite en lames ductiles extrêmement amincies puis cataclaséeset remaniées sur le fond ultrabasique avec des fragments de manteauet de la couverture prérift, durant le dépôt du flysch noir. Latempérature augmente au cours du Cénomanien (480C) dans leszones où le manteau n’a pas été mis à l’affleurement. Le Triassupérieur se transforme profondément (talc-chlorites) et perd sacomposante évaporitique. La couverture prérift décollée joue unrôle majeur comme couvercle isotherme, suivi en cela par les flyschsalbiens puis cénomaniens.A l’Est, le manteau perce à travers une couverture chauffée localementà plus de 600C. Le Keuper y est réduit à quelquesdécimètres de grès et brèches riches en saphirine. La croûtesupérieure a été presque totalement éliminée tectoniquement, maisdes granulites sont remaniées à côté des péridotites et des marbresdans les brèches recouvrant le manteau exhumé.Ces données de terrain représentent les contraintes de base pourconstruire les modèles d’amincissement crustal. La variabilitémise en évidence (gradient thermique et présence ou absence decroûte profonde remaniée) ne permet pas de proposer un modèled’amincissement simple et unique. Cependant, toutes ces donnéesindiquent que la croûte moyenne à supérieure se comporteductilement sous les écrans thermiques de la couverture prériftet synrift, mobiles sur le Keuper. Un modèle de marge passivedistale faisant appel à des blocs continentaux rigides de type ”extensional allochthons ” ne peut s’appliquer ici. Sur la base deces données géologiques, nous mettons donc en avant un nouveaumodèle de type marge distale chaude plus ou moins transtensive.
RST 2016, livre des résumés
Caen, France

insu-01388463
https://hal-insu.archives-ouvertes.fr/insu-01388463

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
We provide new constraints on the modes of mantle exhumation and denudation in the pre-orogenic Pyrenees by investigating the poorly known peridotites located east of the Lherz body, in eastern Ariè ge (Vicdessos, Urs, Bestiac, Caussou and Prades main peridotitic bodies). We show that: (1) numerous peridotite bodies, not described so far, are constituted by decametric to sub-metric outcrops scattered between and around the main outcrops identified by Monchoux (1970); (2) most of the peridotites form blocks and lenses of various sizes, from millimetric monocrystalline grains to hectometric olistoliths, embedded in debris flows involving mainly Mesozoic metasediments; these peridotites can therefore be linked to the S-type peridotites of Lagabrielle et al. (2010), and share similarities with the peridotites of Lherz region (Clerc et al., 2012). All originated from tectono-sedimentary processes associated with mantle exhumation in relation with extreme thinning and breakoff of the continental basement; (3) the various petrographic characters of these peridotites and their heterogeneity in serpentinisation degree imply a peculiar mode of exhumation, which merges mantle fragments inherited from different structural levels; (4) the lack of tectonic structures such as faults and shear planes associated with the ultramafic-rich breccia formation and the presence of neoformation of metamorphic minerals within the matrix preclude their origin as cataclasites related to the Latest Cretaceous and Tertiary Pyrenean contractional deformation. The peridotites of eastern Ariè ge are indisputable witnesses of the presence of an inverted hyper-extended Cretaceous passive margin forming the current North Pyrenean zone. The geometry of the extensional system was complex and probably associated with strike-slip faults and transcurrent motion. ß 2016 The Authors. Published by Elsevier Masson SAS on behalf of Acadé mie des sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).
ISSN: 1631-0713

Droits : http://creativecommons.org/licenses/by-nc-nd/
insu-01280502
https://hal-insu.archives-ouvertes.fr/insu-01280502
https://hal-insu.archives-ouvertes.fr/insu-01280502/document
https://hal-insu.archives-ouvertes.fr/insu-01280502/file/1-s2.0-S1631071316000043-main.pdf
DOI : 10.1016/j.crte.2015.12.003

Éditeur(s) : HAL CCSD
Résumé : International audience
The alarmin IL-33 has been described to be upregulated in human and murine viral hepatitis. However, the role of endogenous IL-33 in viral hepatitis remains obscure. We aimed to decipher its function by infecting IL-33-deficient mice (IL-33 KO) and their wild-type (WT) littermates with pathogenic mouse hepatitis virus (L2-MHV3). The IL-33 KO mice were more sensitive to L2-MHV3 infection exhibiting higher levels of AST/ALT, higher tissue damage, significant weight loss, and earlier death. An increased depletion of B and T lymphocytes, NKT cells, dendritic cells, and macrophages was observed 48 h postinfection (PI) in IL-33 KO mice than that in WT mice. In contrast, a massive influx of neutrophils was observed in IL-33 KO mice at 48 h PI. A transcriptomic study of inflammatory and cell-signaling genes revealed the overexpression of IL-6, TNFα, and several chemokines involved in recruitment/activation of neutrophils (CXCL2, CXCL5, CCL2, and CCL6) at 72 h PI in IL-33 KO mice. However, the IFNγ was strongly induced in WT mice with less profound expression in IL-33 KO mice demonstrating that endogenous IL-33 regulated IFNγ expression during L2-MHV3 hepatitis. In conclusion, we demonstrated that endogenous IL-33 had multifaceted immunoregulatory effect during viral hepatitis via induction of IFNγ, survival effect on immune cells, and infiltration of neutrophils in the liver.
Mediators of Inflammation

hal-01544268
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01544268
DOI : 10.1155/2017/1359064
PUBMED : 28607531
PUBMEDCENTRAL : PMC5457781

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Background & Aims: The severity of liver diseases is exacerbated by the death of hepatocytes, which can be induced by the sensing of pathogen associated molecular patterns (PAMPs) derived from the gut microbiota. The molecular mechanisms regulating these cell death pathways are poorly documented. In this study, we investigated the role of the receptor interacting protein kinase 1 (RIPK1), a protein known to regulate cell fate decisions, in the death of hepatocytes using two in vivo models of PAMP-induced hepatitis. Methods: Hepatitis was induced in mice by independent injections of two different bacterial PAMPs: lipopolysaccharide (LPS) and unmethylated CpG oligodeoxynucleotide (CpG-DNA) motifs. The role of RIPK1 was evaluated by using mice specifically lacking RIPK1 in liver parenchymal cells (Ripk1(LPC-KO)). Administration of liposome-encapsulated clodronate served to investigate the role of Kupffer cells in the establishment of the disease. Etanercept, a tumor necrosis factor (TNF)-decoy receptor, was used to study the contribution of TNF-alpha during LPS-mediated liver injury. Results: Whereas RIPK1 deficiency in liver parenchymal cells did not trigger basal hepatolysis, it greatly sensitized hepatocytes to apoptosis and liver damage following a single injection of LPS or CpG-DNA. Importantly, hepatocyte death was prevented by previous macrophage depletion or by TNF inhibition. Conclusions: Our data highlight the pivotal function of RIPK1 in maintaining liver homeostasis in conditions of macrophage-induced TNF burst in response to PAMPs sensing. Lay summary: Excessive death of hepatocytes is a characteristic of liver injury. A new programmed cell death pathway has been described involving upstream death ligands such as TNF and downstream kinases such as RIPK1. Here, we show that in the presence of LPS liver induced hepatic injury was due to secretion of TNF by liver macrophages, and that RIPK1 acts as a powerful protector of hepatocyte death. This newly identified pathway in the liver may be helpful in the management of patients to predict their risk of developing acute liver failure. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
ISSN: 0168-8278

hal-01532060
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01532060
DOI : 10.1016/j.jhep.2017.01.005
PUBMED : 28088582

Éditeur(s) : HAL CCSD European Geosciences Union
Résumé : International audience
An increasing number of field examples in mountain belts show that the formation of passive margins during extreme continent thinning may occur under conditions of high to very high thermal gradient beneath a thin cover of syn-rift sediments. Orogenic belts resulting from the tectonic inversion of distal margins and regions of exhumed continental mantle may exhibit high-temperature, low-pressure (HT-LP) metamorphism and coeval syn-extensional, ductile deformation. Recent studies have shown that the northern flank of the Pyrenean belt, especially the North Pyrenean Zone, is one of the best examples of such inverted hot, passive margin. In this study, we provide a map of HT-LP metamorphism based on a data set of more than 100 peak-temperature estimates obtained using Raman spectroscopy of the carbona-ceous material (RSCM). This data set is completed by previous PT (pressure and temperature) estimates based on mineral assemblages, and new 40 Ar– 39 Ar (amphibole, micas) and U–Pb (titanite) ages from metamorphic and magmatic rocks of the North Pyrenean Zone. The implications on the geological evolution of the Cretaceous Pyrenean paleomar-gins are discussed. Ages range mainly from 110 to 90 Ma, and no westward or eastward propagation of the metamor-phism and magmatism can be clearly identified. In contrast, the new data reveal a progressive propagation of the thermal anomaly from the base to the surface of the continental crust. Focusing on the key localities of the Mauléon basin, Arguenos–Moncaup, Lherz, Boucheville and the Bas-Agly, we analyze the thermal conditions prevailing during the Cre-taceous crustal thinning. The results are synthetized into a series of three regional thematic maps and into two detailed maps of the Arguenos–Moncaup and Lherz areas. The results indicate a first-order control of the thermal gradient by the intensity of crustal thinning. The highest grades of metamor-phism are intimately associated with the areas where subcon-tinental mantle rocks have been unroofed or exhumed.
ISSN: 1869-9510

insu-01161826
https://hal-insu.archives-ouvertes.fr/insu-01161826
https://hal-insu.archives-ouvertes.fr/insu-01161826/document
https://hal-insu.archives-ouvertes.fr/insu-01161826/file/PL03457.pdf
DOI : 10.5194/se-6-643-2015

Éditeur(s) : HAL CCSD
Résumé : International audience
The geology of the North Pyrenean Zone in the central Pyrenees allows for the observation in the field of theentire section of the Pyrenean rift, from the mantle to the crust and the Mesozoic cover (pre, syn and post rift).The good knowledge we have of the pre-Alpine history of the Pyrenees allows us to properly constrain the Alpinegeological evolution of the pre-Triassic rocks which record both Variscan and Alpine orogenic cycles.The mantle outcrop as kilometric to centimetric fragments of peridotite dispersed within a carbonate metamorphicbreccia. The study of peridotite serpentinisation shows several events of low-temperature serpentinisation, incontact with seawater. In some locallities, we can observe a mixture of fragments of variously serpentinizedperidotites. This suggests a tectonic context where fragments of peridotites from different structural levels weresampled more or less synchronously.The granulitic basement is characterized by a Variscan syndeformational HT event (300-280 Ma). So farwe have not found any trace of a Cretaceous HT event (> 500C). On the other hand, the basement is affectedby a regional metasomatism that began during the Jurassic and became more spatially focused with time until itwas restricted to the Pyrenean rift during the Aptien, Albian and Cenomanian. The talc-chlorite metasomatism(120-95 Ma) shows an evolution from a static toward a syn-deformation hydrothermal event, under a more or lessnormal geothermal gradient. Extensional deformation is recorded by the reworking of several inherited low-angleVariscan tectonic contacts, but also by dispersed high-angle extensional shear zones formed under greenshistconditions.The metamorphic Mesozoic cover of the basement massifs, which constitute the so-called Internal MetamorphicZone, is an allochtonous unit made of lenses of Mesozoic rocks enclosed into the breccia, whichlocally contains peridotite and basement clasts. The Mesozoic metamorphic carbonates show a first phase ofsyn-metamorphic (450-600C, P < 2 kb) ductile deformation, and subsequent phases of folding and fracturing.The datation of neoformed minerals give a 108-85 Ma time span for the metamorphism. We interpret this brecciaas an abandonment breccia which marks the emergence of the main detachment. The basal contact of the Mesozoiccover has a complex 3D geometry traced by Triassic evaporites. It corresponds to a major pre- and synorogenicpolyphased tectonic contact.All these data show a geometrically complex hyper-extended rift where the crust was not stretched under ahigh geothermal gradient but thinned by the tectonic extraction of relatively thin lenses and perhaps cut by highangle low-grade shear zones. The 3D geometry, as well as the strain records and the breccia lithologies stronglysuggest a non-cylindricity for the exhumation process, probably within a transtentional system
Geophysical Research Abstracts
Vienne, Austria

insu-01510371
https://hal-insu.archives-ouvertes.fr/insu-01510371

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Cell death of hepatocytes is a prominent characteristic in the pathogenesis of liver disease, while hepatolysis is a starting point of inflammation in hepatitis and loss of hepatic function. However, the precise molecular mechanisms of hepatocyte cell death, the role of the cytokines of hepatic microenvironment and the involvement of intracellular kinases, remain unclear. Tumor necrosis factor alpha (TNF-α) is a key cytokine involved in cell death or survival pathways and the role of RIPK1 has been associated to the TNF-α-dependent signaling pathway. We took advantage of two different deficient mouse lines, the RIPK1 kinase dead knock-in mice (Ripk1K45A) and the conditional knockout mice lacking RIPK1 only in liver parenchymal cells (Ripk1LPC-KO), to characterize the role of RIPK1 and TNF-α in hepatitis induced by concanavalin A (ConA). Our results show that RIPK1 is dispensable for liver homeostasis under steady-state conditions but in contrast, RIPK1 kinase activity contributes to caspase-independent cell death induction following ConA injection and RIPK1 also serves as a scaffold, protecting hepatocytes from massive apoptotic cell death in this model. In the Ripk1LPC-KO mice challenged with ConA, TNF-α triggers apoptosis, responsible for the observed severe hepatitis. Mechanism potentially involves both TNF-independent canonical NF-κB activation, as well as TNF-dependent, but canonical NF-κB-independent mechanisms. In conclusion, our results suggest that RIPK1 kinase activity is a pertinent therapeutic target to protect liver against excessive cell death in liver diseases. © The Author(s) 2016.
ISSN: 2041-4889

hal-01414916
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01414916
DOI : 10.1038/cddis.2016.362
PUBMED : 27831558

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Brecciated and fractured peridotites with a carbonate matrix, referred to as ophicalcites, are common features of mantle rocks exhumed in passive margins and mid-oceanic ridges. Ophicalcites have been found in close association with massive peridotites, which form the numerous ultramafic bodies scattered along the North Pyrenean Zone (NPZ), on the northern flank of the Pyrenean belt. We present the first field, textural and stable isotopic characterization of these rocks. Our observations show that Pyrenean ophicalcites belong to three main types: (1) a wide variety of breccias composed of sorted or unsorted millimeter- to meter-sized clasts of fresh or oxidized ultramafic material, in a fine-grained calcitic matrix; (2) calcitic veins penetrating into fractured serpentine and fresh peridotite; and (3) pervasive substitution of serpentine minerals by calcite. Stable isotopic analyses (O, C) have been conducted on the carbonate matrix, veins and clasts of samples from 12 Pyrenean ultramafic bodies. We show that the Pyrenean ophicalcites are the product of three distinct genetic processes: (1) pervasive ophicalcite resulting from relatively deep and hot hydrothermal activity; (2) ophicalcites in veins resulting from tectonic fracturing and cooler hydrothermal activity; and (3) polymictic breccias resulting from sedimentary processes occurring after the exposure of subcontinental mantle as portions of the floor of basins which opened during the mid-Cretaceous. We highlight a major difference between the eastern and western Pyrenean ophicalcites belonging, respectively, to the sedimentary and to the hydrothermal types. Our data set points to a possible origin of the sedimentary ophicalcites in continental endorheic basins, but a post-depositional evolution by circulation of metamorphic fluids or an origin from relatively warm marine waters cannot be ruled out. Finally, we discuss the significance of such discrepancy in the characteristics of the NPZ ophicalcites in the frame of the variable exhumation history of the peridotites all along the Pyrenean realm.
ISSN: 1437-3254

insu-00944405
https://hal-insu.archives-ouvertes.fr/insu-00944405
https://hal-insu.archives-ouvertes.fr/insu-00944405/document
https://hal-insu.archives-ouvertes.fr/insu-00944405/file/clerc-etal-IJES-Review.pdf
DOI : 10.1007/s00531-013-0927-z

Éditeur(s) : HAL CCSD American Physiological Society
Résumé : International audience
Interleukin (IL)-33 is crucially involved in liver pathology and drives hepatoprotective functions. However, the regulation of IL-33 by cytokines of the IL-6 family, including oncostatin M (OSM) and IL-6, is not well studied. The aim of the present study was to determine whether OSM mediates regulation of IL-33 expression in liver cells. Intramuscular administration in mice of an adenovirus encoding OSM (AdOSM) leads to increase in expression of OSM in muscles, liver, and serum of AdOSM-infected mice compared with control mice. The increase of circulating OSM markedly regulated mRNA of genes associated with blood vessel biology, chemotaxis, cellular death, induction of cell adhesion molecules, and the alarmin cytokine IL-33 in liver. Steady-state IL-33 mRNA was upregulated by OSM at an early phase (8 h) following AdOSM infection. At the protein level, the expression of IL-33 was significantly induced in liver endothelial cells [liver sinusoidal endothelial cells (LSEC) and vascular endothelial cells] with a peak at 8 days post-AdOSM infection in mice. In addition, we found OSM-stimulated human microvascular endothelial HMEC-1 cells and human LSEC/TRP3 cells showed a significant increase in expression of IL-33 mRNA in a dose-dependent manner in cell culture. The OSM-mediated overexpression of IL-33 was associated with the activation/enrichment of CD4(+)ST2(+) cells in liver of AdOSM-infected mice compared with adenovirus encoding green fluorescent protein-treated control mice. In summary, these data suggest that the cytokine OSM regulates the IL-33 expression in liver endothelial cells in vivo and in HMEC-1/TRP3 cells in vitro and may specifically expand the target CD4(+)ST2(+) cells in liver
ISSN: 0193-1857

hal-01220632
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01220632
DOI : 10.1152/ajpgi.00398.2014
PUBMED : 26251474

Éditeur(s) : HAL CCSD
Résumé : National audience
Dans la région de Bestiac, en haute-Ariège, une coupe nord-sud d’àpeine plus d’un kilomètre de long centrée sur la zone nord-pyrénéennemétamorphique montre les relations entre le socle anté-alpin (gneissgranulitiques et série paléozoïque) du massif nord-pyrénéen du St Barthélémyet de la zone axiale, et la série mésozoïque constituée principalementde marbres et de brèches carbonatées à éléments de lherzolite,mais aussi du flysch crétacé supérieur.A partir de nouvelles données cartographiques, structurales, métamorphiqueset géochronologiques, nous montrons les modalités de l’extensiondans le socle varisque (comment ’escamoter’ la croûte sans ’trop’l’étirer ?), et comment celle-ci a précédé la mise à la surface du manteauet la formation du complexe bréchique. Ces données nous permettentde caractériser l’importance de l’héritage varisque dans la structurationalpine, mais aussi de poser la question de l’impact des déformations alpinesdans ce qui est considéré comme varisque. Enfin, la restaurationde la coupe nous permet d’aborder la question de la géométrie 3D dusystème au Crétacé, et des rôles respectifs des composantes extensiveset décrochantes.
24 ème Réunion des sciences de la Terre 2014
Pau, France

insu-01080833
https://hal-insu.archives-ouvertes.fr/insu-01080833