Éditeur(s) : HAL CCSD European Respiratory Society
Résumé : IF 8.332
International audience
The respiratory manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) have not been studied in detail. In this retrospective multicentre study, EGPA was defined by asthma, eosinophilia and at least one new onset extra-bronchopulmonary organ manifestation of disease. The study population included 157 patients (mean±SD age 49.4±14.1 years), with a mean±SD blood eosinophil count of 7.4±6.4×109 L-1 at diagnosis. There was a mean±SD of 11.8±18.2 years from the onset of asthma to the diagnosis of EGPA, of 1.4±8.4 years from the first onset of peripheral eosinophilia to the diagnosis of EGPA, and of 7.4±6.4 years from EGPA diagnosis to the final visit. Despite inhaled and oral corticosteroid treatment, the severity of asthma increased 3-6 months before the onset of the systemic manifestations. Asthma was severe in 57%, 48%, and 56% of patients at diagnosis, at 3 years, and at the final visit, respectively. Persistent airflow obstruction was present in 38%, 30%, and 46% at diagnosis, at 3 years, and at the final visit, respectively. In EGPA, asthma is severe, antedates systemic manifestations by a mean of 12 years, and progresses to long-term persistent airflow obstruction despite corticosteroids in a large proportion of patients, which affects long-term management and morbidity. Copyright © 2016 ERS.
ISSN: 0903-1936

hal-01406073
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01406073
DOI : 10.1183/13993003.00097-2016
PUBMED : 27587545

Éditeur(s) : Elsevier
Résumé : We examined the potential for producing the large numbers of sandfish (Holothuria scabra) needed for restocking programmes by co-culturing juveniles with the shrimp Litopenaeus stylirostris in earthen ponds. Our experiments in hapas within shrimp ponds were designed to detect any deleterious effects of sandfish on shrimp, and vice versa. These experiments showed that a high stocking density of juvenile sandfish had no significant effects on growth and survival of shrimp. However, survival and growth of sandfish reared with shrimp for 3 weeks were significantly lower than for sandfish reared alone. Increased stocking density of shrimp also had a significant negative effect on survival and/or growth of sandfish. A grow-out trial of juvenile sandfish in 0.2-ha earthen ponds stocked with 20 shrimp post-larvae m(-2), and densities of sandfish between 0.8 and 1.6 individuals m(-2), confirmed that co-culture is not viable. All sandfish reared in co-culture were dead or moribund after a month. However, sandfish stocked alone into 0.2-ha earthen ponds survived well and grew to mean weights of similar to 400 g within 12 months without addition of food. The grow-out trial demonstrated that there is potential for profitable pond farming of sandfish in monoculture. Further research is now needed to identify the optimal size of juveniles, stocking densities and pond management regimes. (C) 2007 Elsevier B.V. All rights reserved.
Aquaculture (0044-8486) (Elsevier), 2007-12 , Vol. 273 , N. 4 , P. 509-519

Droits : 2007 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/2007/publication-3590.pdf
DOI:10.1016/j.aquaculture.2007.07.015
http://archimer.ifremer.fr/doc/00000/3590/

Observing the Oceans in the 21st Century

Droits : GODAE project office
http://archimer.ifremer.fr/doc/00090/20096/17735.pdf
http://archimer.ifremer.fr/doc/00090/20096/

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide a unified interface to biomedical databases that are distributed worldwide. The portal provides access to numerous database projects supported by 30 scientific organizations. It includes over 800 different biological datasets spanning genomics, proteomics, model organisms, cancer data, ontology information and more. All resources available through the portal are independently administered and funded by their host organizations. The BioMart data federation technology provides a unified interface to all the available data. The latest version of the portal comes with many new databases that have been created by our ever-growing community. It also comes with better support and extensibility for data analysis and visualization tools. A new addition to our toolbox, the enrichment analysis tool is now accessible through graphical and web service interface. The BioMart community portal averages over one million requests per day. Building on this level of service and the wealth of information that has become available, the BioMart Community Portal has introduced a new, more scalable and cheaper alternative to the large data stores maintained by specialized organizations.
ISSN: 0305-1048

hal-01146849
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146849
DOI : 10.1093/nar/gkv350
PUBMED : 25897122

Éditeur(s) : HAL CCSD
Résumé : International audience
Chronic obstructive pulmonary disease (COPD) is the chronic respiratory disease with the most important burden on public health in terms of morbidity, mortality and health costs. For patients, COPD is a major source of disability because of dyspnea, restriction in daily activities, exacerbation, risk of chronic respiratory failure and extra-respiratory systemic organ disorders. The previous French Language Respiratory Society (SPLF) guidelines on COPD exacerbations were published in 2003. Using the GRADE methodology, the present document reviews the current knowledge on COPD exacerbation through 4 specific outlines: (1) epidemiology, (2) clinical evaluation, (3) therapeutic management and (4) prevention. Specific aspects of outpatients and inpatients care are discussed, especially regarding assessment of exacerbation severity and pharmacological approach.
Revue Des Maladies Respiratoires

hal-01560287
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01560287
DOI : 10.1016/j.rmr.2017.03.034
PUBMED : 28552256

Éditeur(s) : HAL CCSD Springer
Résumé : Third International Workshop, MLMI 2012, Held in Conjunction with MICCAI 2012
International audience
Universal Nearest Neighbours (unn) is a classifier recently proposed, which can also effectively estimates the posterior probability of each classification act. This algorithm, intrinsically binary, requires the use of a decomposition method to cope with multiclass problems, thus reducing their complexity in less complex binary subtasks. Then, a reconstruction rule provides the final classification. In this paper we show that the application of unn algorithm in conjunction with a reconstruction rule based on the posterior probabilities provides a classification scheme robust among different biomedical image datasets. To this aim, we compare unn performance with those achieved by Support Vector Machine with two different kernels and by a k Nearest Neighbours classifier, and applying two different reconstruction rules for each of the aforementioned classification paradigms. The results on one private and five public biomedical datasets show satisfactory performance.
Machine Learning in Medical Imaging
Nice, France

hal-00958909
https://hal.archives-ouvertes.fr/hal-00958909
https://hal.archives-ouvertes.fr/hal-00958909/document
https://hal.archives-ouvertes.fr/hal-00958909/file/Miccai.pdf
DOI : 10.1007/978-3-642-35428-1_15

Éditeur(s) : HAL CCSD
Résumé : International audience
South-east Iran is the site of a rare case of young transition between subduction and collision. We synthesized recent results in geodesy, tectonics, seismology and magnetism to understand the structure and kinematics of the Zagros-Makran transition. Surface observations (tectonics, magnetism and geodesy) draw a transpressive discontinuity consisting of several faults striking obliquely to the convergent plate motion, whereas deeper observations (seismology) support a smooth transition across the fault system. No lithospheric transform fault has been created, even though the transition already behaves like a major boundary in terms of tectonic style, seismic structure, lithology and magnetism. The Zendan-Minab-Palami fault system consists of several faults that accommodate a transpressive tectonic regime. It is the surface expression of a southward propagation of the N-trending right-lateral strike-slip fault system of Jiroft-Sabzevaran. Within each system the numerous faults will coalesce into a single, lithospheric, wrench fault.
ISSN: 0375-6440

hal-00356532
https://hal.archives-ouvertes.fr/hal-00356532
https://hal.archives-ouvertes.fr/hal-00356532/document
https://hal.archives-ouvertes.fr/hal-00356532/file/Regard_MinabSynthese_revised_AvecFigs.pdf
DOI : 10.1144/SP330.4

Éditeur(s) : HAL CCSD
Résumé : International audience
Objective To guide nosology and classification of patients with eosinophilic granulomatosis with polyangiitis (EGPA) based on phenotype and presence or absence of ANCA. Methods Organ manifestations and ANCA status were retrospectively analyzed based on the presence or not of predefined definite vasculitis features or surrogates of vasculitis in patients asthma, eosinophilia, and at least one systemic organ manifestation attributable to systemic disease. Results The study population included 157 patients (mean age 49.4 ± 14.1), with a follow-up of 7.4 ± 6.4 years. Patients with ANCA (31%) more frequently had weight loss, myalgias, arthralgias, biopsy-proven vasculitis, glomerulonephritis on biopsy, hematuria, leukocytoclastic capillaritis and/or eosinophilic infiltration of arterial wall on biopsy, and other renal disease. A total of 41% of patients had definite vasculitis manifestations (37%) or strong surrogates of vasculitis (4%), of whom only 53% had ANCA. Mononeuritis multiplex was associated with systemic vasculitis (p = 0.005) and with the presence of ANCA (p < 0.001). Overall, 59% of patients had polyangiitis as defined by definite vasculitis, strong surrogate of vasculitis, mononeuritis multiplex, and/or ANCA with at least one systemic manifestation other than ENT or respiratory. Patients with polyangiitis had more systemic manifestations including arthralgias (p = 0.02) and renal disease (p = 0.024), had higher peripheral eosinophilia (p = 0.027), and a trend towards less myocarditis (p = 0.057). Using predefined criteria of vasculitis and surrogates of vasculitis, ANCA alone were found to be insufficient to categorise patients with vasculitis features. Conclusion We suggest a revised nomenclature and definition for EGPA and a new proposed entity referred to as hypereosinophilic asthma with systemic (non vasculitic) manifestations. © 2016 Elsevier B.V.
Autoimmunity Reviews

hal-01467544
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467544
DOI : 10.1016/j.autrev.2016.09.018
PUBMED : 27671089

Éditeur(s) : HAL CCSD
Résumé : International audience
Recent studies have shown that accounting for intraspecific trait variation (ITV) may better address major questions in community ecology. However, a general picture of the relative extent of ITV compared to interspecific trait variation in plant communities is still missing. Here, weconducted a meta-analysis of the relative extent of ITV within and among plant communities worldwide, using a data set encompassing 629 communities (plots) and 36 functional traits. Overall, ITV accounted for 25% of the total trait variation within communities and 32% of the totaltrait variation among communities on average. The relative extent of ITV tended to be greater for whole-plant (e.g. plant height) vs. organ-level traits and for leaf chemical (e.g. leaf N and P concentration) vs. leaf morphological (e.g. leaf area and thickness) traits. The relative amount of ITV decreased with increasing species richness and spatial extent, but did not vary with plant growth form or climate. These results highlight global patterns in the relative importance of ITV in plant communities, providing practical guidelines for when researchers should include ITV in trait-based community and ecosystem studies.
Ecology Letters

hal-01237101
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237101
DOI : 10.1111/ele.12508
PUBMED : 26415616

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
P>The Strait of Hormuz area is a transition zone between the continental collision of the Zagros (west) and the subduction of an oceanic part of the Arabian Plate beneath the Makran wedge (east). Geology and recent GPS measurements indicate that about 15 mm yr-1 of relative motion in N10 degrees E direction is accommodated by two major fault systems: (1) the NNW-trending Minab-Zendan-Palami (MZP) fault system that connects the Main Zagros Thrust (MZT) to the inner Makran thrust system and the Frontal subduction thrust and (2) the N-trending Sabzevaran-Kahnuj-Jiroft (SKJ) fault system that bounds the Jazmurian depression to the west. We use dense GPS measurements along four transects across these fault systems in order to determine the strains spatial distribution. The northern GPS transect confirms the total fault slip rates for both fault systems estimated by the tectonic analyses (about 10 and 7.3 mm yr-1 in N10 degrees direction across the MZP and SKJ fault systems, respectively). For both fault systems, the elastic deformation spreads over shear zones that are several tens of kilometres wide. However, transects located close to latitude 27 degrees N reveal a much narrower shear zone (similar to 10 km) for the MZP fault system. Moreover, we confirm that most of the present-day strain is transferred towards the frontal subduction thrust rather than towards the inner Makran thrusts. In order to complement this new GPS velocity field with spatially dense measurements, we processed a set of ERS radar images by the radar interferometry (InSAR) technique. We used both a 'stacking' and a 'persistant-scatterers' approach to differentiate the ground deformation signal which spatial gradient is expected to be very low, from the atmospheric signal. Results from these interferograms appear to be relatively in agreement with the GPS-determined strain distribution. Nevertheless, they confirm the absence of any superficial creep behaviour since no sharp discontinuity on interferometric phase can be noted on any interferogram. Finally, we use a purely kinematic 'block model' inversion process to calculate slip rates and locking depths for each fault system from our GPS measurements. These models suggest that the relative quiescence over the last 200 yr has certainly produced a slip deficit as high as 2 m. So, we may wonder if the MZP fault system is not late in the interseismic phase of its earthquake cycle.
ISSN: 0956-540X

hal-00429386
https://hal.archives-ouvertes.fr/hal-00429386
DOI : 10.1111/j.1365-246X.2009.04321.x