Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
Among 103 patients with multidrug-resistant HIV who initiated raltegravir, etravirine, and darunavir/ritonavir-containing regimen in the ANRS 139 TRIO trial, 100 participated in extended follow-up and continued study treatment until week 96. Among them, 87 (87%) received an optimized background therapy including either nucleoside reverse transcriptase inhibitors or enfuvirtide, they were 78 (78%) at week 96. At week 96, 88% achieved durable virologic response (<50 copies/mL). CD4 response was maintained (median change of +150 cells/mm(3)). No major toxicity was reported. This triple drug combination showed sustained efficacy and thus should be strongly considered for patients with multiclass-resistant virus.
ISSN: 1525-4135

hal-00875207
https://hal.archives-ouvertes.fr/hal-00875207
DOI : 10.1097/QAI.0b013e31824bb720
PUBMED : 22293546

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case-control study comprised 410 patients who had surgery for a pituitary tumour with long-term follow-up. Using pituitary magnetic resonance imaging for diagnosis of cavernous or sphenoid sinus invasion, immunocytochemistry, markers of the cell cycle (Ki-67, mitoses) and p53, tumours were classified according to size (micro, macro and giant), type (PRL, GH, FSH/LH, ACTH and TSH) and grade (grade 1a: non-invasive, 1b: non-invasive and proliferative, 2a: invasive, 2b: invasive and proliferative, and 3: metastatic). The association between patient status at 8-year follow-up and age, sex, and classification was evaluated by two multivariate analyses assessing disease- or recurrence/progression-free status. At 8 years after surgery, 195 patients were disease-free (controls) and 215 patients were not (cases). In 125 of the cases the tumours had recurred or progressed. Analyses of disease-free and recurrence/progression-free status revealed the significant prognostic value (p < 0.001; p < 0.05) of age, tumour type, and grade across all tumour types and for each tumour type. Invasive and proliferative tumours (grade 2b) had a poor prognosis with an increased probability of tumour persistence or progression of 25- or 12-fold, respectively, as compared to non-invasive tumours (grade 1a). This new, easy to use clinicopathological classification of pituitary endocrine tumours has demonstrated its prognostic worth by strongly predicting the probability of post-operative complete remission or tumour progression and so could help clinicians choose the best post-operative therapy.
ISSN: 0001-6322

hal-00875723
https://hal.archives-ouvertes.fr/hal-00875723
DOI : 10.1007/s00401-013-1084-y
PUBMED : 23400299

Éditeur(s) : HAL CCSD MDPI AG, Basel, Switzerland
Résumé : International audience
Abstract View references (46)This work shows the preparation of silica membranes by a two-step sol-gel method using tetraethyl orthosilicate in ethanolic solution by employing nitric acid and ammonia as co-catalysts. The sols prepared in pH 6 resulted in the lowest concentration of silanol (Si-OH) species to improve hydrostability and the optimized conditions for film coating. The membrane was tested to desalinate 0.3-15 wt % synthetic sodium chloride (NaCl) solutions at a feed temperature of 22 °C followed by long term membrane performance of up to 250 h in 3.5 wt % NaCl solution. Results show that the water flux (and salt rejection) decrease with increasing salt concentration delivering an average value of 9.5 kg m-2 h-1 (99.6%) and 1.55 kg m-2 h-1 (89.2%) from the 0.3 and 15 wt % saline feed solutions, respectively. Furthermore, the permeate salt concentration was measured to be less than 600 ppm for testing conditions up to 5 wt % saline feed solutions, achieving below the recommended standard for potable water. Long term stability shows that the membrane performance in water flux was stable for up to 150 h, and slightly reduced from thereon, possibly due to the blockage of large hydrated ions in the micropore constrictions of the silica matrix. However, the integrity of the silica matrix was not affected by the long term testing as excellent salt rejection of >99% was maintained for over 250 h. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
ISSN: 2077-0375

hal-01683203
https://hal.univ-antilles.fr/hal-01683203
DOI : 10.3390/membranes3030136

Éditeur(s) : HAL CCSD
Résumé : During the course of their life cycle organisms are exposed to natural environment variations capable of inducing physiological, morphological and behaviour changes, thus a phenotypic plasticity. Phenotypic plasticity is the ability of a genotype to generate a new phenotype following exogeneous or endogeneous stress. Here, we investigated the phenotypic plasticity of the non-calcifying symbiotic cnidarian Anemonia viridis at multiple levels of structural complexity, in vivo and in vitro. In vivo, we determined the mechanisms behind the phenotypic plasticity under expected future climate change (i.e. ocean acidification and ocean warming). Our results show physiological changes in the inorganic carbon use of the sea anemone A. viridis exposed to high pCO2 during a long-term stress in natura or a short-term stress in controlled conditions. We then observed an equivalent decrease in carbonic anhydrase activity, a key enzyme of cnidarian carbon concentrating mechanisms. Also, we demonstrated that an increase in seawater temperature modified the response observed during a high pCO2 scenario. In vitro, we established a viable primary cell culture from regenerating tentacles of A. viridis. We determined the gastrodermal tissue origin of the cultivated cells and validated the use of this new tool to the in vitro study of stress response at the cellular level. The set-up of this powerful in vitro tool will open a multitude of perspectives for the study of cellular responses to exogeneous stress (as global change perturbations) and to endogeneous stress (as the symbiosis constraints experienced by symbiotic cnidarians)
Durant leur cycle de vie, les organismes sont exposés à des variations environnementales capables d'induire des changements physiologiques, morphologiques et comportementaux, résultant d’une plasticité phénotypique. La plasticité phénotypique est la capacité d'un génotype à générer un nouveau phénotype suite à un stress. Ici, nous avons étudié la plasticité phénotypique d’un Cnidaire symbiotique et non-calcifiant, l’anémone de mer Anemonia viridis, à de multiples niveaux de complexité structurale, in vivo et in vitro. In vivo, nous avons identifié les mécanismes sous-jacents de la plasticité phénotypique potentiellement induits par les futurs changements climatiques (acidification et réchauffement des océans). Nos résultats montrent des modifications dans l'utilisation du carbone inorganique par A. viridis exposée à une forte pCO2 lors d’un stress chronique in natura ou lors d’un stress court en conditions contrôlées. Nous avons ainsi observé une diminution des activités anhydrase carbonique, une enzyme clé des mécanismes de concentration du carbone chez les Cnidaires. Nous avons aussi démontré que l'augmentation concomittante de la température modifie la réponse observée lors d'une élévation seule de la pCO2. In vitro, nous avons établi une culture de cellules primaires viables issue de tentacules d’A. viridis en régénération. Nous avons déterminé l'origine gastrodermale des cellules cultivées et validé l'utilisation de ce nouvel outil pour l'étude de la réponse au stress au niveau cellulaire. Ce nouvel outil ouvre une multitude de perspectives pour l'étude des réponses cellulaires aux stress exogènes (changement climatique) et endogènes (contraintes dues à la symbiose)
https://tel.archives-ouvertes.fr/tel-01674220

Droits : info:eu-repo/semantics/OpenAccess
NNT : 2016AZUR4136
tel-01674220
https://tel.archives-ouvertes.fr/tel-01674220
https://tel.archives-ouvertes.fr/tel-01674220/document
https://tel.archives-ouvertes.fr/tel-01674220/file/2016AZUR4136.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Up-to-date estimates of the health outcomes of preterm children are needed for assessing perinatal care, informing parents, making decisions about care, and providing evidence for clinical guidelines. To determine survival and neonatal morbidity of infants born from 22 through 34 completed weeks' gestation in France in 2011 and compare these outcomes with a comparable cohort in 1997. The EPIPAGE-2 study is a national, prospective, population-based cohort study conducted in all maternity and neonatal units in France in 2011. A total of 2205 births (stillbirths and live births) and terminations of pregnancy at 22 through 26 weeks' gestation, 3257 at 27 through 31 weeks, and 1234 at 32 through 34 weeks were studied. Cohort data were collected from January 1 through December 31, 1997, and from March 28 through December 31, 2011. Analyses for 1997 were run for the entire year and then separately for April to December; the rates for survival and morbidities did not differ. Data are therefore presented for the whole year in 1997 and the 8-month and 6-month periods in 2011. Survival to discharge and survival without any of the following adverse outcomes: grade III or IV intraventricular hemorrhage, cystic periventricular leukomalacia, severe bronchopulmonary dysplasia, retinopathy of prematurity (stage 3 or higher), or necrotizing enterocolitis (stages 2-3). A total of 0.7% of infants born before 24 weeks' gestation survived to discharge: 31.2% of those born at 24 weeks, 59.1% at 25 weeks, and 75.3% at 26 weeks. Survival rates were 93.6% at 27 through 31 weeks and 98.9% at 32 through 34 weeks. Infants discharged home without severe neonatal morbidity represented 0% at 23 weeks, 11.6% at 24 weeks, 30.0% at 25 weeks, 47.5% at 26 weeks, 81.3% at 27 through 31 weeks, and 96.8% at 32 through 34 weeks. Compared with 1997, the proportion of infants surviving without severe morbidity in 2011 increased by 14.4% (P < .001) at 25 through 29 weeks and 6% (P < .001) at 30 through 31 weeks but did not change appreciably for those born at less than 25 weeks. The rates of antenatal corticosteroid use, induced preterm deliveries, cesarean deliveries, and surfactant use increased significantly in all gestational-age groups, except at 22 through 23 weeks. The substantial improvement in survival in France for newborns born at 25 through 31 weeks' gestation was accompanied by an important reduction in severe morbidity, but survival remained rare before 25 weeks. Although improvement in survival at extremely low gestational age may be possible, its effect on long-term outcomes requires further studies. The long-term results of the EPIPAGE-2 study will be informative in this regard.
ISSN: 2168-6211

hal-01258705
http://hal.univ-brest.fr/hal-01258705
PUBMED : 25621457
DOI : 10.1001/jamapediatrics.2014.3351

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999 15-19 octobre 1999
Résumé : In Curacao, deep-water fads with grp surface buoys were developed and tested. The first fad was deployed in 1993. Up to now, a total of 5 fads were deployed at the following depths: 730, 685, 700, 754 and 574 metres. Changes were made to the surface buoy, resulting in an improved design, the mkii surface buoy. One fad lasted three years and one month. The main features of the design used are: the use of a sparbuoy design with constant tension on the moving chain to avoid slamming and jerking of the surface buoy; liberal use of sacrificial anodes, and maintenance to replace these anodes about once a year; the use of a short anchor chain with depth buoys, that does not touch bottom; a one-piece inverted mushroom anchor. With the grp surface buoy, a reserve buoyancy of approximately 800 kg is obtained with chain as external ballast about 610 kg of net buoyancy remains (it would seem that the reserve buoyancy needed where strong currents occur, has been underestimated in many designs). Five new grp mkii buoys are now under construction. Utilizing the experience gained with the deep-water fads, two new types of fads made of 500 mm diameter pvc tubes were designed to be used in waters of shallow and medium depth (150-400 m). One design uses a 3-m length of pvc tube, the other a 5-m tube (500 mm diameter). One fad with 3-m pvc buoy has been tested succesfully, two 5-m pvc buoys are under construction. The use of pvc results in a buoy which is substantially less expensive than a grp buoy. On the other hand, this type of buoy can probably not withstand the same forces as a grp buoy and we assume that for use in deeper waters the grp mkii buoy will still be needed.

Droits : Ifremer
http://archimer.ifremer.fr/doc/00042/15288/12674.pdf
http://archimer.ifremer.fr/doc/00042/15288/

Éditeur(s) : HAL CCSD
Résumé : International audience
In this work, we have led an analysis of the error of different global solar radiation prediction models according to the global solar radiation variability. Different predictions models where performed such as machine learning techniques (Neural Networks, Gaussian processes and support vector machines) in order to forecast the Global Horizontal solar Irradiance (GHI). We also include in this study a simple linear autoregressive (AR) model as well as two naive models based on persistence of the GHI and persistence of the clear sky index (denoted herein scaled persistence model). The models are calibrated and tested with data from three 3 French islands: Corsica (42.15°N ; 9.08°E), Guadeloupe (16.25°N ; 61.58°W) and Reunion (21.15°S ; 55.5°E). Guadeloupe and Reunion are located in a subtropical climatic zone whereas Corsica is in a tempered climatic zone. Hence the global solar radiation variation differs significantly. The output error of the different models was quantified by the nRSME. In order to quantify the influence of the global solar radiation variability on the forecasting models error we performed a classification of typical days according to different typical days. Each class of typical day is defined by a variation of global solar radiation rate. For each class and for each location, the selected forecasting models where performed and the error was quantified. With this analysis a global solar radiation forecasting models can be selected according to the location, the global solar radiation fluctuations and hence the meteorological conditions. INTRODUCTION Large and frequent variations of solar radiation can be observed in tropical climates with amplitudes reaching 800 W/m² and occurring within a short time interval, from few seconds to few minutes, according to the geographical location. Such fluctuations can be due for example to the dynamic of clouds which can be very complex and depend on cloud type, size, speed and spatial distribution and, more generally, due to some specific local meteorological conditions. Thus, the solar energy forecasting, a process used to predict the amount of solar energy available in the current and near terms, might be a difficult task. Some of the best predictors found in literature are Autoregressive and moving average (ARMA) [5,7,8], Bayesian inferences [9,10], Markov chains [11], k-Nearest-Neighbors predictors [12] or artificial intelligence techniques as the Artificial Neural Network (ANN) [9-11]. Although these methodologies are potentially good in many areas, we observed in our previous studies on global radiation prediction [9,13,14] that the simple model based on the persistence of the clear sky index gives often very good results with acceptable errors [15] for short term forecasting time horizon (<= 1 hour). The goal of this paper is to determinate the influence of solar radiation variability regarding different classes of days on the expected error provided by different forecasting methods that the modeller can possibly implement. The paper is organized as follow: Section 2 describes the data we have used. Section 3 exposes the classification methodology and the results obtained for the three studied locations. In the two following sections, the forecasting methods are exposed and then 3 the errors on the forecasting results for each location and for each class are exposed.
The Third Southern African Solar Energy Conference (SASEC2015)
Kruger National Park, South Africa

Droits : info:eu-repo/semantics/OpenAccess
hal-01099487
https://hal.archives-ouvertes.fr/hal-01099487
https://hal.archives-ouvertes.fr/hal-01099487/document
https://hal.archives-ouvertes.fr/hal-01099487/file/article%20SASEC.pdf

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
Malaria remains one of the most common vector-borne diseases in the world and the definition of novel control strategies can benefit from the modeling of transmission processes. However, data-driven models are often difficult to build, as data are very often incomplete, heterogeneous in nature and in quality, and/or biased. In this context, a knowledge-based approach is proposed to build a robust and general landscape-based hazard index for malaria transmission that is tailored to the Amazonian region. A partial knowledge-based model of the risk of malaria transmission in the Amazonian region, based on landscape features and extracted from a systematic literature review, was used. Spatialization of the model was obtained by generating land use and land cover maps of the cross-border area between French Guiana and Brazil, followed by computing and combining landscape metrics to build a set of normalized landscape-based hazard indices. An empirical selection of the best index was performed by comparing the indices in terms of adequacy with the knowledge-based model, intelligibility and correlation with P. falciparum incidence rates. The selected index is easy to interpret and successfully represents the current knowledge about the role played by landscape patterns in malaria transmission within the study area. It was significantly associated with P. falciparum incidence rates, using the Pearson and Spearman correlation coefficients (up to 0.79 and 0.75, respectively; p-value < 0.001), and the linear regression coefficient of determination (reaching 0.63; p-values < 0.001). This study establishes a spatial knowledge-driven, landscape-based hazard malaria index using remote sensing that can be easily produced on a regular basis and might be useful for malaria prediction, surveillance, and control. Keywords: remote sensing; land use and land cover; landscape metric; knowledge-based hazard modeling; malaria; cross-border area between French Guiana and Brazil
ISSN: 2072-4292

hal-01355255
https://hal.archives-ouvertes.fr/hal-01355255
https://hal.archives-ouvertes.fr/hal-01355255/document
https://hal.archives-ouvertes.fr/hal-01355255/file/010066865.pdf
IRD : fdi:010066865

Éditeur(s) : HAL CCSD European Respiratory Society
Résumé : IF 8.332
International audience
The respiratory manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) have not been studied in detail. In this retrospective multicentre study, EGPA was defined by asthma, eosinophilia and at least one new onset extra-bronchopulmonary organ manifestation of disease. The study population included 157 patients (mean±SD age 49.4±14.1 years), with a mean±SD blood eosinophil count of 7.4±6.4×109 L-1 at diagnosis. There was a mean±SD of 11.8±18.2 years from the onset of asthma to the diagnosis of EGPA, of 1.4±8.4 years from the first onset of peripheral eosinophilia to the diagnosis of EGPA, and of 7.4±6.4 years from EGPA diagnosis to the final visit. Despite inhaled and oral corticosteroid treatment, the severity of asthma increased 3-6 months before the onset of the systemic manifestations. Asthma was severe in 57%, 48%, and 56% of patients at diagnosis, at 3 years, and at the final visit, respectively. Persistent airflow obstruction was present in 38%, 30%, and 46% at diagnosis, at 3 years, and at the final visit, respectively. In EGPA, asthma is severe, antedates systemic manifestations by a mean of 12 years, and progresses to long-term persistent airflow obstruction despite corticosteroids in a large proportion of patients, which affects long-term management and morbidity. Copyright © 2016 ERS.
ISSN: 0903-1936

hal-01406073
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01406073
DOI : 10.1183/13993003.00097-2016
PUBMED : 27587545

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Le changement climatique et le développement durable du tourisme représentent des enjeux majeurs pour l’avenir du tourisme dans plusieurs régions du monde, notamment aux Antilles françaises. Aussi, la présente étude se propose d’analyser et d’évaluer les effets économiques de la variation climatique sur le secteur touristique à la Guadeloupe et à la Martinique, pour quatre raisons essentielles : (a) le secteur du tourisme et les petites économies insulaires qui en dépendent, comme celles de la Guadeloupe et de la Martinique, sont fortement sensibles à la variabilité et au changement du climat. (b) la vulnérabilité intrinsèque de ces petites destinations et de leurs infrastructures à l’élévation du niveau de la mer et aux évènements climatiques extrêmes (cyclones, inondations, sécheresse), (c) la haute dépendance de l’industrie touristique régionale à l’utilisation des énergies fossiles, (d) enfin, en raison du fait qu’aucune évaluation économique chiffrée n’a été produite à ce jour sur les effets économiques de la la variation climatique sur le secteur touristique à la Guadeloupe et à la Martinique. Par conséquent, il importe de cerner dans ces deux régions les conséquences possibles de ce changement au plan touristique et d’envisager le cas échéant des stratégies d’adaptation et d’atténuation. Ce faisant, cette étude se fixe quatre objectifs principaux : (a) examiner les facteurs qui influencent la demande et l’offre de tourisme aux Antilles Françaises ; (b) effectuer à l’aide d’un modèle de demande touristique, l’impact économique de ces facteurs sur le nombre d’arrivées ainsi que sur la dépense touristique dans ces régions ; (c) évaluer et projeter en termes de coût, les effets du changement climatique sur l’activité touristique ; et (d) proposer aux autorités locales, des stratégies d’adaptation et d’atténuation face au défi du changement climatique.L’évaluation de ces différents effets est abordée ici à l’aide d’un modèle structurel de base (MSB) et d’un modèle structurel général (MSG), inspirés tous deux des travaux de Harvey (1990) pour capter à l’aide d’un indice climato-touristique, les éléments du climat qui impactent l’activité touristique. Cet indice synthétique est calculé en se basant sur les données climatiques du passé selon deux scénarios climatiques proposés par le groupe d’experts intergouvernemental sur l’évolution du climat (GIEC) – un scénario pessimiste A2, et un scénario optimiste B2-. Les résultats issus de l’application de ces modèles montrent que les caractéristiques climato-touristiques de la Guadeloupe et de la Martinique subiront vraisemblablement un déclin à long terme, et devraient au plan économique impacter négativement le secteur touristique de ces destinations, se traduisant par des pertes à la fois d’attractivité et de chiffre d’affaires du secteur. Les pertes subies par le tourisme en raison du changement climatique s’élèveraient à l’horizon 2100, et selon le scénario A2, à 45 millions d’euros à la Guadeloupe soit 0,7% de son PIB 2004, et à 60 millions d’euros à la Martinique soit 0,8% de son PIB 2004.
Climate change and the tourism sustainable development are important challenges for tourism future trends of many countries, including the French West Indies. Therefore, this study provides an evaluation of the likely economic effects of climate change on tourism sector in Guadeloupe and Martinique, and identifies four reasons why these countries should be concerned about the potential effects of climate change on tourism: (a) Guadeloupe and Martinique are island destinations very sensitive to climate change; (b) their intrinsic vulnerability and their infrastructure to sea level rise and extreme climatic events (e.g. hurricanes and floods); (c) the high dependence of their tourist industry on carbon-based fuels; and (d) up to date, no economic evaluation of climate change on tourism sector in Guadeloupe and Martinique is provided. Therefore, this study attempted to quantify the likely effects of the changes in the climatic factors on the economy of the French West Indies. There are four main objectives in this study. The first is to examine the factors that influence the demand and supply tourism in Guadeloupe and Martinique. The second is to forecast the impact of climate change to tourism arrivals until 2050 under two scenarios from the intergovernmental panel on climate change (IPCC) – A2: pessimistic scenario and B2: optimistic scenario-. Third is to evaluate and forecast the cost of climate change to the tourism sector until 2100. The fourth is to recommend to authorities the adaptation and mitigation strategies that can be undertaken by the tourism sector to French West Indies to address climate change.Following Harvey (1990), a Basic Structural Model (BSM) and a General structural Model (GSM), are employed to model tourist arrivals to Martinique. A tourism climatic index (TCI) conceptualized by Mieczkowski (1985) is used in this model to capture the elements of climate that impact on a destination’s experience. The results suggest that under both scenarios, the island’s key tourism climatic features will probably decline, and therefore, negatively impact on the destination experience of visitors. Tourism losses due to climate change are projected in 2100 to 45 millions euros in Guadeloupe, or 0.7% of its GDP, and to 60 millions euros in Martinique, or 0,8% of its GDP.
Guadeloupe
Martinique

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.6750
http://journals.openedition.org/etudescaribeennes/6750

Éditeur(s) : HAL CCSD
Résumé : International audience
Continental erosion and weathering destroy parts of the stratigraphic record. Analyses of the sedimentary filling of paleokarsts help completing the geological record of regions that have been submitted to post-depositional, long-term, continental evolution. Jurassic carbonate platform of Languedoc (South of France) has undergone several karstification phases from Cretaceous to Neogene. Later incision of canyons through the carbonate massifs allows to observe paleokarsts over 400m depth, within the massifs. Paleokarsts are partly filled with sediments. Some have yielded marine bioclasts (echinoderms, radiolars), foraminifera and nannofossils; others are composed of polygenic detrital sediments, including sources from the upstream Paleozoic basement (Cevennes). The age of the filling of successive paleokarsts can be constrained by structural relationships and by biostratigraphy. These findings suggests 1) the marine elements of the karstic filling relate to a Late Cretaceous to Early Paleocene interval, while 2) the Paleozoic basement-sourced-sediments were trapped in the karst during Miocene to Present. Karstic sediment containing Early Paleocene foraminifera and nannofossils are found in paleokarsts cavities distributed across the entire thickness of the carbonate massif (≥350m). This requires base-level lowering and associated karstification, followed by base-level rise and karst filling of at least 350 m amplitude, respectively. The time interval corresponding to the occurrence of foraminifera and nannofossils in karsts covers 10 Myrs ; surprisingly, no equivalent marine sediments are preserved on the surface. In addition, analyses of the different forams species suggests several (up to 3) distinct karstification and marine filling cycles. Finally, sedimentological facies analysis of the karst filling reveals the following succession of processes: low energy settling of mudstone, high energy reworking, transport and deposition of silts and sandstones within the karst system. Integration of geological, paleontological and sedimentological data, leads to a polyphase scenario in response to repeated base-level variations, more than 350m amplitude. Such an amplitude excludes eustacy, and the improbable repeated sequence of uplift and subsidence rules out tectonics, as driving forces for base-level change, respectively. We propose that the high-amplitude base-level changes results from a succession of desiccation-flooding events of an endorheic, silled, basin during Early Paleogene. The later detrital assemblage sourced in the Cevennes occurs on perched paleosurfaces and in karst cavities across the whole 350m-deep canyon walls. When found on paleosurfaces, they correspond to the south-flowing Early Miocene fluvial drainage, and can be correlated downstream with the marine, well dated, Early Miocene, sediments. When found within the karst cavities, they correspond to successive base-level surfaces connected to the progressive incision of the canyon. This canyon incision is coeval with a Late Miocene uplift of the hinterland.
24th International Karstological School "Classical karst" : Paleokarst
Postojna, Slovenia

hal-01306683
https://hal-brgm.archives-ouvertes.fr/hal-01306683
https://hal-brgm.archives-ouvertes.fr/hal-01306683/document
https://hal-brgm.archives-ouvertes.fr/hal-01306683/file/Abstract_IKS.pdf

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
PURPOSE: Multiple myeloma, a hematological malignancy generally affecting elderly people, was diagnosed at the beginning of the pregnancy of a 33-year-old woman. We carried out a literature review in order to evaluate the consequences of this cancer on pregnancy and of pregnancy on multiple myeloma, as to determine the specific follow-up required. METHODS: A systematic search for articles of interest published between 1949 and 16 November 2010 was performed in MEDLINE, SCOPUS and EMBASE, using the words "multiple myeloma" and "pregnancy". We identified 398 publications of potential interest, 20 of which were selected and included in the analysis. RESULTS: The selected articles included 26 cases. No specific risk factors were identified in pregnant women. The most common presentations were bone pain and/or anemia, as in the general population. Pregnancy seemed to have no effect on multiple myeloma progression. Most pregnancies went to term, with only two medical terminations and six cesareans performed before term, due to the severity of the cancer. No effect of the cancer or its treatment by chemotherapy during pregnancy was found in the children. CONCLUSION: Pregnancy does not seem to be contraindicated in women with multiple myeloma. Nevertheless, the management of pregnant patients with multiple myeloma is a diagnostic, therapeutic and social challenge, requiring a multidisciplinary approach and regular follow-up. Decisions should be taken based on the severity of the disease, its prognosis and maternal choice.
ISSN: 0932-0067

hal-00682571
https://hal.archives-ouvertes.fr/hal-00682571
DOI : 10.1007/s00404-011-1985-8
PUBMED : 21786002

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
OBJECTIVE: The WEGENT trial and other short-term studies suggested that azathioprine or methotrexate could effectively maintain granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) remission. Whether differences in relapse or adverse event rates would appear after discontinuation of those 2 maintenance regimens and longer follow-up remains unknown. METHODS: Long-term outcomes for the patients enrolled in the WEGENT trial were analyzed according to their randomization group. Parameters at trial entry were evaluated as potential prognostic factors for death, relapse or damage in multivariate models. RESULTS: Data were returned for 88.8% of the 126 original participants. Median [95% confidence interval] followup was 11.9 [11.3-12.5] years. For the azathioprine and methotrexate arms, respectively, the 10-year overall survival rates were 75.1% [64.8-86.9] and 79.9% [70.3-90.8] (P = 0.56), and relapse-free survival rates 26.3% [17.3-40.1] and 33.5% [23.5-47.7] (P = 0.29). No between-arm differences were observed for relapse, adverse events, damage, survival rates without severe side effects and survival rates without relapse and severe side effects. Considering only the 97 GPA patients, no between-arm survival differences were observed. Relapse-free survival was shorter for GPA than MPA patients but the multivariate analysis retained anti-PR3-ANCA-positivity, and not GPA, as being independently associated with relapse. CONCLUSION: This long-term analysis confirms that azathioprine and methotrexate are comparable options for maintaining GPA or MPA remission. Despite good overall survival, relapses, adverse events and damage remain matters of concern and further studies are needed to reduce them.
ISSN: 2326-5205

hal-01217989
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217989
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217989/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217989/file/Long-term%20outcomes%20of%20the%20WEGENT%20trial_accepted.pdf
DOI : 10.1002/art.39450

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: A prospective study of infectious encephalitis was conducted in France in 2007. In total, 253 patients were enrolled with a proven etiological diagnosis for 52%. The cohort of surviving patients with encephalitis was assessed for sequelae and impairment 3 years after enrollment. METHODS: Patients, their family, and general practitioners (GPs) were interviewed by phone to document persisting symptoms, return to work, and past and current leisure activities, with standardized questionnaires. The IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly) was completed with relatives. The global outcome was determined in all patients with the Glasgow outcome scale. RESULTS: In 2010, 20 patients (10%) were unavailable for follow-up, 2 (1%) were excluded, and 18 (9%) had died since hospital discharge. Data were available for 167 survivors and 9 patients whose death was related to the encephalitis. The outcome was favorable in 108 of 176 patients (61%) (71 with complete resolution), 31 (18%) were mildly impaired, 25 (14%) were severely impaired, and 3 (1%) were in a vegetative state. The most frequent symptoms were difficulty concentrating (42%), behavioral disorders (27%), speech disorders (20%), and memory loss (19%). Fifteen of 63 patients (24%) previously employed were still unable to resume work. Long-term outcome was significantly associated with comorbid conditions, age, level of education, and the causative agent of encephalitis. CONCLUSIONS: Most patients with encephalitis experienced a favorable outcome 3 years after hospital discharge. However, minor to severe disability persists in a high number of cases with consequences for everyday life. Physical and mental impairment should be evaluated in all patients with encephalitis, and neuropsychological rehabilitation implemented whenever needed.
ISSN: 1058-4838

hal-00875190
https://hal.archives-ouvertes.fr/hal-00875190
DOI : 10.1093/cid/cis226
PUBMED : 22460967

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999
Résumé : A new programme concerning the experimentation of about thirty Fish Aggregating Devices (FADs) is to start in the Cape Verde Islands at the end of 1999. In this context, this communication is intended: - to evaluate the halieutic, economic and social conditions of the artisanal fishery in this archipelago, notably in terms of assets and constraints. Although these conditions are very heterogeneous depending on islands, the fads seem to be able to help the stabilization and the development of the fishing activities, disadvantaged by a low productivity, limited operating ranges of boats, and very irregular outings at sea. But the narrowness of the domestic market is likely to cause drops in the fish prices if the production increases, while the absence of institutional framework may be a handicap at the level of the management (of the programme itself, and/or of some possible conflicts of uses); - to carry out an assessment of the former experiments. It emphasized the insufficiency of the follow-up and the maintenance of the structures, of which the lifespan varied at the most between four and six months, as well as the positive effects of the concentration, and the interest of the fishermen already sensitized with these structures.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00042/15317/12644.pdf
http://archimer.ifremer.fr/doc/00042/15317/

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
OBJECTIVE: To evaluate the incidence and determinants of diabetes in a cohort of HIV-infected adults initiated with combination antiretroviral treatment (cART) in 1997-1999 and followed up to 2009. DESIGN: Prospective study of 1046 patients at 47 French clinical sites. METHODS: Potential determinants of diabetes occurrence, defined by confirmed increased glycemia and/or initiation of antidiabetic treatment, were assessed by a proportional hazards model, including time-updated metabolic parameters and ART exposure. RESULTS: Among the cohort, representing 7846 person-years of follow-up (PYFU), 54% received indinavir, 75% stavudine and 52% didanosine. Overall, 111 patients developed diabetes, with an incidence of 14.1/1000 PYFU (14.6 in men, 12.6 in women). Incidence peaked in 1999-2000 (23.2/1000 PYFU) and decreased thereafter. The incidence of diabetes was associated [adjusted hazard ratio (aHR), all P<0.02] with older age (hazard ratio = 2.13 when 40-49 years, hazard ratio = 3.63 when ≥50 years), overweight (hazard ratio = 1.91 for a BMI 25-29 kg/m(2), hazard ratio = 2.85 >30 kg/m(2)), waist-to-hip ratio (hazard ratio = 3.87 for ≥0.97 male/0.92 female), time-updated lipoatrophy (hazard ratio = 2.14) and short-term exposure to indinavir (0-1 year: hazard ratio = 2.53), stavudine (0-1 year: hazard ratio = 2.56, 1-2 years: hazard ratio = 2.65) or didanosine (2-3 years: hazard ratio = 3.16). Occurrence of diabetes was not associated with HIV-related markers, hepatitis C, hypertension or family history of diabetes. Insulin resistance was predictive for incident diabetes. CONCLUSIONS: In this nationwide cohort, followed for 10 years after cART initiation, diabetes incidence peaked in 1990-2000, was markedly higher than that reported for European uninfected or other HIV-infected populations (4-6/1000 PYFU) and linked with age and adiposity. Adiposity and glycemic markers should be monitored in aging HIV-infected patients.
ISSN: 0269-9370

hal-00875222
https://hal.archives-ouvertes.fr/hal-00875222
DOI : 10.1097/QAD.0b013e32834e8776
PUBMED : 22089377

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : Aim The aim of the present study was to examine whether listening to music during warming-up might influence short-term maximal performance (STMP), cognitive anxiety, self-confidence, and enjoyment during Ramadan, and whether these affects might predict STMP. Methods Nine male physical education students (age: 21 ± 1.1 years; height: 1.8 ± 0.04 m; body mass: 83 ± 5 kg) volunteered to participate in the present study. A within-subjects design consisted of four experimental sessions: Two sessions occurred one week before Ramadan and two others took place during Ramadan. They were scheduled at 5 p.m. and were conducted as follows: After a 10-minute warm-up either with or without listening to music, each participant performed a 5-m multiple shuttle run test, after which he was asked to answer items intended to assess his affective state during the experimental task. Results Our findings revealed that STMP was lower during Ramadan than before Ramadan in the no-music condition. Additionally, it was found that STMP was higher in the music condition than in the no-music condition during Ramadan, and that STMP measured before Ramadan did not differ from that measured during Ramadan in the music condition. Regarding affects, the findings revealed that enjoyment was lower during Ramadan than before Ramadan in the music condition, and that cognitive anxiety was lower in the music condition than in the no-music condition before Ramadan. Self-confidence was not influenced by the experimental conditions. Conclusion This study showed that listening to music during warming-up not only would be beneficial for STMP in Ramadan fasters, but also would counteract the negative effects of Ramadan observance on STMP.
ISSN: 1932-6203

hal-01467699
https://hal-univ-paris10.archives-ouvertes.fr/hal-01467699
DOI : 10.1371/journal.pone.0136400

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Mixtures of polybrominated diphenyl ethers (PBDEs) are present in indoor environments. Studies of the developmental effects of exposure to these chemicals in large prospective mother-child cohorts are required, with data on prenatal exposure and long-term follow-up of the children. We aimed to investigate the relationship between prenatal and childhood exposure to PBDEs and neurodevelopment at the age of six years. We determined the levels of PBDEs and other neurotoxicants in cord blood and dust collected from the homes of children for 246 families included in the PELAGIE mother-child cohort in France. We assessed two cognitive domains of the six-year-old children using the Wechsler Intelligence Scale for Children-IV. Verbal comprehension scores were lower in children from homes with higher concentrations of BDE99 (βDetects < median_vs_NonDetects = −1.6; 95% CI: −6.1, 2.9; βDetects≥median_vs_NonDetects = −5.4; −9.9, −1.0; ptrend = 0.02) and of BDE209 (β2nd_vs₁st_tertile = −1.8; 95% CI: −6.1, 2.5; β3rd_vs₁st_tertile = −3.2; −7.5, 1.2; ptrend = 0.15) in dust, particularly for boys (ptrend = 0.02 and 0.04, respectively). Working memory scores seemed to be lower in children with higher BDE99 concentrations in dust (ptrend = 0.10). No association was observed with cord blood levels of BDE209. Our findings are in agreement with those of four previous studies suggesting adverse cognitive outcomes among children associated with early-life exposure to penta-BDE mixtures, and provide new evidence for the potential neurotoxicity of BDE209. Several countries are in the process of banning the use of PBDE mixtures as flame-retardants. However, these compounds are likely to remain present in the environment for a long time to come
ISSN: 0161-813X

hal-01286255
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01286255
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01286255/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01286255/file/Childhood%20exposure%20to%20polybrominated%20diphenyl-accepted.pdf
DOI : 10.1016/j.neuro.2016.03.002

Résumé : This study aims to integrate the problems associated with port development and related activities in an economic monitoring programme that surveys all the activities associated with the marine environment. The economic monitoring programme in this sector also includes studying coastal spatial planning. This type of study concerns the creation and remodelling of sites that involve investments. We can consider two types of coastal spatial planning: one which integrates port development, tourism, aquaculture and fisheries and one that deals with the marine environment (Abric, 1989). Economic surveys of port development on French coasts supposes that the problem of identifying information sources have been resolved and the sectors and the activities that should be accounted for have been characterised. In what follows, the limits of available information and the problems pertaining to the proposed classification of activities according to statistical nomenclature will be discussed. The absence of structured and localised data is aggravated in certain cases by the rules of confidentiality. In light of these difficulties, the first part of this report is devoted to the inventory of general information sources and to the characterisation of existing data. As information forms the basis of any economic monitoring programme, it is necessary to know where, how and by whom information is processed and the limits that one comes up against. This report does not pretend to be exhaustive given the deadlines and the duration of this study. The second part of this report constitutes a summary of the recent trends discerned in terms of port development, from a legal, as well as economic and financial, point of view. This study should be considered as the first step to establishing a basis for a more in-depth study.
Cette étude a pour but d'intégrer les problèmes d'aménagement portuaire et les activités qui y sont liées dans un suivi conjoncturel de l'ensemble des activités économiques en relation avec le milieu maritime. Le suivi conjoncturel de ce secteur économique passe aussi par l'étude de l'aménagement physique du littoral. Celui-ci concerne la création et le remodelage de sites impliquant des investissements. On peut considérer deux types d'aménagements physiques -l'aménagement du littoral : portuaire, touristique, aquacole, halieutique; -l'aménagement du mineur marin (Abric, 1989). Un suivi conjoncturel de l'aménagement portuaire du littoral français, suppose en préalable la résolution du problème de l'identification des sources d'information et la caractérisation des secteurs et activités en prendre en compte. On verra par la suite les limites de l'information disponible et les problèmes afférents a la classification des activités selon les nomenclatures statistiques proposées. L'absence de données structurées et localisées est aggravée dans certains cas par des règles de confidentialité. Du fait de ces difficultés, la première partie de ce rapport est consacrée au recensement des sources d'information générale et à la caractérisation des données existantes. L'information étant à la base de tout suivi conjoncturel, il convient en effet d'être en mesure de savoir où, par qui et comment elle est traitée et les limites auxquelles on se heurte. Ce rapport ne peut prétendre à l'exhaustivité compte tenu des délais et de la période d'exécution de cette étude. La seconde partie constitue une première synthèse sur les évolutions récentes saisies en termes d'aménagements portuaires, tant d'un point de vue juridique qu'économique et financier. Cette étude est à considérer comme une première étape destinée à poser les bases pour une étude plus approfondie. [OCR NON CONTRÔLE]

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1992/rapport-4169.pdf
http://archimer.ifremer.fr/doc/00000/4169/

Éditeur(s) : Proceedings of the 60th GCFI Conference, Punta Cana, Dominican Republic, 5 - 9 Nov 2007. pp.1-11
Résumé : The development of the ecosystemic approach for fisheries supposes to improve integrated analysis of fisheries by considering the biological as well as the socio-economic dimensions of the exploitation. A prerequisite for integrated analysis is the improvement in the knowledge of fleets structure, fleet evolution and allocation of fishing effort in the different fisheries. However, small scale fisheries are often characterized by a lack of knowledge on the vessel fishing activity. This paper first presents a data collection methodology recently applied in the French West (Guadeloupe and Martinique) for the follow up of the whole vessel population. Based on a statistical analysis of these data sets, the paper develops a fleet-metier matrix giving the possibility to identify the structure of the fleet, the metier polyvalence of the vessels but also the origin of fishing mortality on the different exploited fishing resources. We then discuss the interest of this methodology for fisheries analysis and the perspective in terms of fisheries management at regional levels.
Le développement de l’approche écosystémique des pêches suppose de renforcer les analyses couplant les dimensions biologiques et socio-économiques de l’exploitation. Cela passe en particulier par une meilleure connaissance des flottilles de pêche, de leur évolution et l’allocation de l’effort de pêche dans les différentes pêcheries. Dans un contexte de connaissance souvent très limitée sur l’activité de navires de petite pêche, ce papier présente la méthodologie de collecte de données utilisée, dans le cas des îles des Antilles françaises (Guadeloupe et Martinique). Sur la base d’une collecte de données minimale mais exhaustive de l’activité des navires, le papier propose le développement une analyse matricielle (flottilles-métiers) permettant de caractériser la structure des flottilles de pêche, d’identifier leur polyvalence en termes de métiers pratiqués et l’origine de la mortalité par pêche. On discute enfin l’intérêt de ce type d’approche pour l’analyse de pêcheries ainsi que les perspectives pour la gestion des pêches.
El desarollo del estudio del ecosistema de las pescas supone que hay que intensificar los análisis considerando a la vez las dimensiones biológicas y socio-económicas de la explotación. Esto supone un mejor conocimiento de las flotillas de pesca, de su evolucíon y de la atribución del esfuerzo de pesca en las diferentes pesquerías. Sabiendo que los conocimientos sobre la actividad de los buques de pequeña pesca son muchas veces limitados, este documento presenta la metodología de recolección de informaciones estadísticas dada en el caso de las islas de las antillas francesas (Guadeloupe y Martinique). Basándose en una recoleccíon de informaciones estadísticas mínima pero eschaustiva de la actividad de los buques, este documento propone el desarollo de un análisis de las matrices (flotillas-metiers) que permite caracterizar la estructura de las flotillas de pesca y de identificar su caracter polivalente en términos de metiers practicados. No solo permite discutir sobre el impacto de las políticas que tienden a reorientar el esfuerzo de pesca de las especies de los bancos insulares hacia las especies pelágicas, sino también permite discutir sobre el interés de generalizar este tipo de recolección de informaciones estadísticas en los sistemas de observación de las pesquerías a escala de las pequeñas Antillas o de otros espacios pertinentes para la gestión de las pescas. Palabras llaves : flotillas, metiers, actividad de pesca, pequeña pesca, gestión de las pescas

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00243/35456/33985.pdf
http://archimer.ifremer.fr/doc/00243/35456/