Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0003-4975

hal-01563338
http://hal.univ-brest.fr/hal-01563338
DOI : 10.1016/j.athoracsur.2016.03.093
PUBMED : 27262916

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
ISSN: 0959-8049

hal-01666517
https://hal.univ-lorraine.fr/hal-01666517
DOI : 10.1016/j.ejca.2015.11.024

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the whole HIV population and in various risk groups over the next 10 years in France using a transmission dynamic compartmental model.Methods: The model was based on epidemiological data from the French Dat’AIDS cohort. Eight risk groups wereconsidered, including high-risk (HR) and low-risk (LR) men who have sex with men (MSM) and male/female heterosexuals,intra-venous drug users, or patients from other risk groups. The model was calibrated on prevalence and incidence dataobserved in the cohort between 2012 and 2015.Results: On January 1, 2016, 156,811 patients were registered as infected with HIV in France (24,900 undiagnosedpatients) of whom 7938 (5.1%) had detectable HCV-RNA (722 undiagnosed patients). Assuming a treatmentcoverage (TC) rate of 30%/year (i.e., the observed rate in 2015), model projections showed that HCV prevalenceamong HIV patients is expected to drop to 0.81% in 2026. Sub-analyses showed a similar decrease of HIV-HCVprevalence in most risk groups, including LR MSM. Due to higher infection and reinfection rates, predicted prevalencein HR MSM remained stable from 6.96% in 2016 to 6.34% in 2026. Increasing annual TC rate in HR MSM to 50/70%would decrease HCV prevalence in this group to 2.35/1.25% in 2026. With a 30% TC rate, undiagnosed patients wouldaccount for 34% of HCV infections in 2026.Conclusions: Our model suggests that DAA could nearly eliminate coinfection in France within 10 years for most riskgroups, including LR MSM. Elimination in HR MSM will require increased TC.
ISSN: 1741-7015

Droits : info:eu-repo/semantics/OpenAccess
inserm-01685739
http://www.hal.inserm.fr/inserm-01685739
http://www.hal.inserm.fr/inserm-01685739/document
http://www.hal.inserm.fr/inserm-01685739/file/2017%2C%20Virlogeux%20-%20Modeling%20HIV-HCV%20coinfection.pdf
DOI : 10.1186/s12916-017-0979-1

Éditeur(s) : Wiley-blackwell Publishing, Inc
Résumé : Recent theoretical and field studies conducted in both terrestrial and marine ecosystems have suggested that diversity could be a more complex and multi-component concept than previously thought. However, it is still poorly understood to what extent the information provided by the various indices is complementary with regard to diversity, and to what extent this complementarity is reproducible in different situations or at different scales of observation. In the present work, we have analysed the reproducibility of the empirical relationships between 11 diversity indices related to four major aspects (components) of species diversity (species richness, rarity, evenness and species taxonomy) in order to determine whether there is a general pattern of redundancy or complementarity in diversity measures that holds across years, areas and spatial scales. We have applied this approach to groundfish diversity through the analysis of 2404 trawl hauls collected during the first large-scale annual surveys carried out using a single sampling design throughout the northern Mediterranean Sea (ranging from 36.3 to 45.7 degrees N, and 5.3 degrees W to 28 degrees E). Whatever the years, areas and scales studied, we found a strong reproducibility in the number and the nature of the main complementary components of diversity. The whole set of diversity indices considered may be roughly split into 6 complementary groups of descriptors. This result highlights that, in contrast to what is still the usual practice, monitoring diversity should not be based on only one or two of the most widely used components, even at large scale. Finally, in a context where developing tools for monitoring diversity is considered as a high priority worldwide, the strong reproducibility of the relationships between diversity indices we observed offers a basis for discussion of the feasibility and relevance of proposing a general shortlist of indices for monitoring diversity at different management scales.
Ecography (0906-7590) (Wiley-blackwell Publishing, Inc), 2010-12 , Vol. 33 , N. 6 , P. 1123-1135

Droits : 2010 The Authors / Ecography
http://archimer.ifremer.fr/doc/00029/14064/11382.pdf
DOI:10.1111/j.1600-0587.2009.06259.x
http://archimer.ifremer.fr/doc/00029/14064/

Résumé : Ce document présente l'état des principaux stocks exploités par les flottes françaises en termes de mortalité par pêche et de biomasse de reproducteurs. La situation fin 2010 (début 2011) par rapport aux points de référence (de précaution et Fmsy) est indiqué lorsque les indicateurs sont estimés et que les références sont définies. Les grandes tendances en matière d'évolution des mortalités et biomasses sont également indiquées.

Droits : 2011 Ifremer
http://archimer.ifremer.fr/doc/00035/14656/11956.pdf
http://archimer.ifremer.fr/doc/00035/14656/

Éditeur(s) : Société Française d’Ichtyologie
Résumé : Following the volcanic eruption of April 2007 at Reunion Island, 12 specimens of the pomacentrid genus Chromis were collected at sea surface. One of these fishes was a C. chrysura known from the reef Island fauna. The others have enlarged eyes. Among them were one C. axillaris (Bennett, 1831), new for the Island fauna, and ten specimens of a new Chromis species, described here under the name C. durvillei. This new species of deep dwelling Chromis is distinguishable by large sized eyes 1.9 to 2.4 in the head length, D. XIII, 12-13, 25 to 26 gill-rakers on the first gill arch, three spiniform procurrent caudal rays, without black or dark brown spot or band on the body, pectorals or caudal peduncle. C. axillaris, C. woodsi, C. unipa, C. okamurai, C. struhsakeri and generally C. mirationis have 14 spinous dorsal rays. C. abyssicola and rarely C. mirationis have 13 spinous dorsal rays but two spiniform procurrent caudal rays and a dark axillary spot on pectorals.
Parmi les poissons récoltés en surface à l’île de la Réunion (océan Indien sud-ouest), après l’éruption volcanique d’avril 2007, se trouvaient 12 exemplaires du genre Chromis. Un C. chrysura connu de la faune récifale de l’île et 11 exemplaires présentant des yeux de grande taille : un C. axillaris (Bennett, 1831), nouveau pour la faune de l’île de La Réunion et 10 Chromis distinguables des autres espèces du genre par des yeux de grande taille (1,9 à 2,4 fois dans la longueur de la tête), D. XIII , 12-13, 25 à 26 branchicténies sur le premier arc branchial, trois rayons caudaux procurrents épineux et l’absence de tache ou de bande de couleur foncée sur le corps, les pectorales ou le pédoncule caudal. C. axillaris, C. woodsi, C. unipa, C. okamurai, C. struhsakeri et C. mirationis ont 14 rayons épineux à la dorsale, alors que C. abyssicola et rarement C. mirationis n’en ont que 13, mais deux rayons caudaux procurrents et une tache axillaire noire sur les pectorales. Cette espèce nouvelle de Chromis est décrite sous le nom de C. durvillei.
Cybium (0399-0974) (Société Française d’Ichtyologie), 2009-12 , Vol. 33 , N. 4 , P. 321-326

Droits : 2009 Société Française d’Ichtyologie
http://archimer.ifremer.fr/doc/00003/11382/8006.pdf
http://archimer.ifremer.fr/doc/00003/11382/

Éditeur(s) : ISTPM
Résumé : L'essor de la pêche aux Antilles représente un atout important dans le développement économique et social des Petites Antilles, encore faut-il en déterminer les possibilités, les limites et les moyens. C'est à cette tâche que l'Institut Scientifique et Technique des Pêches Maritimes s'est appliqué depuis son implantation en Martinique. Pour les espèces pélagiques, il s'agissait, en premier lieu, de faire l'inventaire des ressources qu'offrent les eaux antillaises, et d'en préciser le niveau d'exploitation actuel.
Science et Pêche (0036-8350) (ISTPM), 1981-04 , Vol. 312 , P. 1-15

Droits : Ifremer
http://archimer.ifremer.fr/doc/1981/publication-7178.pdf
http://archimer.ifremer.fr/doc/00000/7178/

Éditeur(s) : HAL CCSD Ferrata Storti Foundation
Résumé : International audience
BackgroundRecent evidence suggests that autonomic nervous system activity could be involved in thepathophysiology of sickle cell disease, but it is unclear whether differences in autonomic nervoussystem activity are detectable during steady state in patients with mild and severe disease.The aim of the present study was to compare the autonomic nervous system activity, bloodrheology, and inflammation in patients with sickle cell anemia according to the frequency ofacute pain crisis.Design and MethodsTwenty-four healthy volunteers, 20 patients with sickle cell anemia with milder disease, and15 patients with sickle cell anemia with more severe disease were recruited. Milder disease wasdefined as having no pain crisis within the previous year. More severe disease was defined ashaving had within the previous year three or more pain crises which were documented by aphysician and required treatment with narcotics. The autonomic nervous system activity wasdetermined by spectral analysis of nocturnal heart rate variability. Blood viscosity determinationand measurements of several inflammatory markers (interleukin-6, soluble vascular celladhesion molecule-1, soluble CD40 ligand and sL-selectin) were made on blood samples collectedin steady-state conditions.ResultsResults showed that: 1) patients who had suffered more frequent pain crises had lowerparasympathetic activity and greater sympatho-vagal imbalance than both controls andpatients with milder disease. However, when adjusted for age, no significant difference wasdetected between the two sickle cell anemia patient groups; 2) patients who had suffered morefrequent pain crises had higher blood viscosity than patients with milder disease, and this wasnot dependent on age.ConclusionsResults from the present study indicate that both the autonomic nervous system activity andblood viscosity are impaired in patients with sickle cell anemia exhibiting high frequency ofpain crisis in comparison with those who did not experience a crisis within the previous year.
ISSN: 0390-6078

hal-01163973
https://hal.univ-antilles.fr/hal-01163973
DOI : 10.3324/haematol.2011.047365

Éditeur(s) : HAL CCSD
Résumé : International audience
Radiocarbon dating and "old wood problem" in the Antilles : the state of the artAmong the many effects that may distort the interpretation of radiocarbon dates are those for which the age of the archaeological event is different from the radiocarbon age of the sample or "14C event" age. This type of problem arises in many cases, notably in the "old wood effect”, and occurs in various regions of the world where very long-lived trees species are common. In the Caribbean anthracological studies indicate a very high frequency of some indigenous centuries-old species such as Guaiacum, Guaiacum officinale L. However the absence of tree-ring data in humid tropical zones deprives us of an accurate inventory of long-lived species and especially the assessment of their longevity. Here we present measurements which enable us to estimate the longevity of archaeological Guaiacum wood posts. They highlight a gap of several centuries between wood from the outer edge and the heart of the tree. This example illustrates the additional uncertainty that can result from dating archeological events when dates are realized on unidentified botanical species from which the area that was sampled is unknown. Another source of error could arise from the use of rot-proof dead wood as fuel if we take into consideration that major hurricanes can produce large amounts of dead wood that may be collected for decades, even centuries. To improve chronometric data used in archaeological interpretations, it is necessary to ensure the quality of the dating process by following a protocol similar to those used in other regions of the world based on a better understanding of the material to be dated by preliminary identifications of wood samples: species, anatomical part, wood moisture content (unseasoned or seasoned).
Radiocarbono y "problema madera vieja", que data de las Antillas: estado del arteEntre los muchos efectos que pueden distorsionar la interpretación de fechas de radiocarbono, destacan aquellos para los que la edad de la prueba arqueológica es diferente de la edad de radiocarbono de la muestra, o la edad del "evento de radiocarbono." Este tipo de problema se presenta en muchos casos, especialmente uno llamado "efecto madera vieja." Esto se refleja en diversas regiones del mundo donde las especies de plantas de mucha longevidad son comunes. En el Caribe, los estudios antracológicos disponibles indican una muy alta frecuencia de algunas especies autóctonas como el guayaco, Guaiacum officinale L. Sin embargo, la casi ausencia de datos de anillos de árboles en los trópicos húmedos, nos impide realizar un inventario exacto de especies de mucha longevidad y sobre todo la evaluación de la longevidad. Algunas de las pruebas presentadas aquí permitieron una estimación de la longevidad de de unos postes de guayaco de origen arqueológico. Ponen de manifiesto una brecha de varios siglos entre las partes externas y el corazón del tronco. Este ejemplo ilustra la aparición de una incertidumbre adicional en la datación de los eventos arqueológicos cuando no conocemos la especie botánica y tampoco la zona de la muestra en el árbol. Otra fuente de error puede surgir de la utilización de la madera muerta de calidad duradera como combustible ya que los grandes huracanes pueden producir grandes cantidades de madera muerta, que puede ser requerida durante décadas, incluso siglos. Para mejorar los datos cronométricos utilizados en interpretaciones arqueológicas, es necesario asegurarse de la calidad de las fechas, y por lo tanto seguir un protocolo similar a los utilizados en otras regiones fundado en una mejor comprensión de los elementos: especie, parte anatómica, humedad de la madera usada (verde o seco).
Parmi les nombreux effets susceptibles de fausser l’interprétation des datations par le radiocarbone, figurent ceux pour lesquels l’âge de l’événement archéologique est différent de l’âge radiocarbone de l’échantillon, ou âge de l’« événement radiocarbone ». Ce type de problème se pose dans de nombreux cas, en particulier celui dénommé « effet vieux bois ». Cette question est prise en compte dans diverses régions du monde où des espèces végétales très longévives sont fréquentes. Dans les Antilles les études anthracologiques disponibles indiquent une fréquence très importante de certaines espèces autochtones multiséculaires dont le gaïac, Guaiacum officinale L.. Cependant, la quasi absence de données dendrochronologiques dans la zone tropicale humide, nous privent d’un inventaire précis des espèces longévives et surtout de l’évaluation de leur longévité. Quelques tests présentés ici ont permis une estimation de la longévité de poteaux d’origine archéologique en bois de gaïac. Ils mettent en évidence un décalage de plusieurs siècles entre les parties externes et le cœur du tronc. Cet exemple illustre l’apparition d’une incertitude supplémentaire dans la datation de l’événement archéologique lorsque que l’on ne connaît ni l’espèce botanique ni la zone de prélèvement dans l’arbre. Une autre source d’erreur pourrait provenir de l’utilisation de bois mort de qualité très durable comme combustible, sachant que les grands cyclones peuvent produire d’importantes quantités de bois mort susceptible d’être récolté pendant des décennies, voire des siècles. Afin d’améliorer les données chronologiques utilisées dans les interprétations archéologiques, il apparaît nécessaire de s’assurer de la qualité des datations, et donc de suivre un protocole similaire à ceux utilisés dans d’autres régions basé sur une meilleure connaissance des éléments datés : espèce, partie anatomique, humidité du bois utilisé (vert ou sec).
Puerto Rico 2013 : Actas del 25to Congreso Internacional de Arqueología del Caribe - Proceeding of the 25th International Congress for Caribbean Archeology - Comptes rendus des communications du 25e Congrés International de l'Archéologie de la Caraïbe
San-Juan, Puerto Rico

hal-01198567
https://hal.archives-ouvertes.fr/hal-01198567
https://hal.archives-ouvertes.fr/hal-01198567/document
https://hal.archives-ouvertes.fr/hal-01198567/file/Stouvenot%20et%20al.%202015.%20Effet%20vieux%20bois%20radiocarbone%20Antilles%20HD.pdf

Éditeur(s) : HAL CCSD
Résumé : Présentation orale
Q7
besancon, France

hal-00481847
https://hal.archives-ouvertes.fr/hal-00481847

Éditeur(s) : Edp Sciences S A
Résumé : This work aims to define a typology of trawler f1eet in Sète, the main fishing harbour along the French Mediterranean coast, using several multivariate analysis methods. The fishing ships taken to account are represented by annual profiles of landing specific compositions. Five fishing strategies have been identified. A segmentation method using symbolic objects allows a formaI characterisation of the different strategies. These strategies are studied according to several general characteristics usually used for management rules elaboration (power, length, ship age). The typological analysis allows to characterise two main exploitation ways, one directed to the catch of a few species (Engraulis encrasicolus, Sardina pilchardus), the other characterised by the exploitation of a great diversity of species. By this way, it is possible to estimate how the catch of low represented species can significantly contribute to the exploitation of a resource.
Cette étude s'appuie sur l'utilisation successive de plusieurs méthodes d'analyses multivariées pour réaliser une typologie de la flottille chalutière du port de Sète, principal port de pêche français de la Méditerranée. Les unités de pêche étudiées sont représentées à l'aide d'un profil annuel de la composition spécifique de leurs débarquements. Cinq stratégies de pêche ont ainsi pu être identifiées. La mise en oeuvre d'une méthode de segmentation permet une caractérisation formelle de ces différentes stratégies à l'aide d'objets symboliques. Les stratégies sont étudiées en référence à plusieurs caractéristiques générales couramment utilisées en gestion des flottilles de pêche (puissance, longueur, âge du bateau, etc.). L'analyse typologique mise en oeuvre au cours de l'étude permet de caractériser nettement deux grandes logiques d'exploitation, l'une orientée vers la recherche d'un très petit nombre d'espèces (Engraulis encrasicolus, Sardina pilchardus), l'autre déterminée par une grande diversité des captures. Elle permet également d'apprécier comment les captures d'espèces peu représentées dans certaines stratégies peuvent contribuer significativement à l'exploitation d'une ressource
Aquatic Living Resources (0990-7440) (Edp Sciences S A), 1997 , Vol. 10 , N. 3 , P. 137-148

Droits : IFREMER-Gauthier-Villars
http://archimer.ifremer.fr/doc/00113/22404/20101.pdf
DOI:10.1051/alr:1997015
http://archimer.ifremer.fr/doc/00113/22404/

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
OBJECTIVE: The WEGENT trial and other short-term studies suggested that azathioprine or methotrexate could effectively maintain granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) remission. Whether differences in relapse or adverse event rates would appear after discontinuation of those 2 maintenance regimens and longer follow-up remains unknown. METHODS: Long-term outcomes for the patients enrolled in the WEGENT trial were analyzed according to their randomization group. Parameters at trial entry were evaluated as potential prognostic factors for death, relapse or damage in multivariate models. RESULTS: Data were returned for 88.8% of the 126 original participants. Median [95% confidence interval] followup was 11.9 [11.3-12.5] years. For the azathioprine and methotrexate arms, respectively, the 10-year overall survival rates were 75.1% [64.8-86.9] and 79.9% [70.3-90.8] (P = 0.56), and relapse-free survival rates 26.3% [17.3-40.1] and 33.5% [23.5-47.7] (P = 0.29). No between-arm differences were observed for relapse, adverse events, damage, survival rates without severe side effects and survival rates without relapse and severe side effects. Considering only the 97 GPA patients, no between-arm survival differences were observed. Relapse-free survival was shorter for GPA than MPA patients but the multivariate analysis retained anti-PR3-ANCA-positivity, and not GPA, as being independently associated with relapse. CONCLUSION: This long-term analysis confirms that azathioprine and methotrexate are comparable options for maintaining GPA or MPA remission. Despite good overall survival, relapses, adverse events and damage remain matters of concern and further studies are needed to reduce them.
ISSN: 2326-5205

hal-01217989
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217989
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217989/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217989/file/Long-term%20outcomes%20of%20the%20WEGENT%20trial_accepted.pdf
DOI : 10.1002/art.39450

Éditeur(s) : HAL CCSD
Résumé : International audience
New guidelines have been produced by the CNSF and the CNGOF regarding the use of oxytocin after spontaneous onset of labor in France. This clinical practices were designed to redefine the normal and abnormal obstetrical labor; specify the indications, dosage, procedures, and effects of oxytocin administration; and describe the adverse maternal and perinatal effect associated with oxytocin administration.
31st International Confederation of Midwives (ICM) trienal congress
Toronto, France

Droits : http://creativecommons.org/licenses/by-nc/
hal-01564458
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01564458
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01564458/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01564458/file/Poster%20CNSF%20pour%20ICM%20Toronto%20-%20Juin%202017.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Plio-Pleistocene diatomitic sequences in the Shamb paleo-lake (South Armenia, Lesser Caucasus) offer a rare opportunity to give new insights on the paleo-climate of Western Asia. We present an integrated palynological, 40Ar/39Ar geochronologic and magnetostratigraphic study for the most complete section in the sedimentary deposits of the Shamb paleo-lake. 40Ar/39Ar dating of two volcaniclastic layers provided ages of 1.24 ± 0.03 and 1.16 ± 0.02 Ma (2. Magnetostratigraphic data show that the entire Shamb section is of reversed polarity which, combined with 40Ar/39Ar dating, suggests that the entire section correlates with part of the Matuyama period (1.785-1.070 Ma). Pollen assemblages and macroremains diversity clearly show an alternation of glacial and interglacial phases. Age calibrations and accumulation rate extrapolation allow a direct correlation of climate changes with the global isotopic curve, and show that the Shamb section probably ranges from approximately 1.300 to 1.080 Ma (marine isotopic stages 40 to 31). The vegetation of the Lesser Caucasus developed in a mosaic pattern in a Pleistocene continental, mostly arid climate, comparable to the present-day climate. The observed vegetation changes record a dominant climate response to the obliquity orbital parameter, but the influence of precession could not be established from the Shamb data. Pollen and macroflora both indicate that glacial periods were cold and dry and that interglacials were warm with local humidity. The early Pleistocene climatic model for Western Asia is thus similar to the climatic model for the Mediterranean area.
ISSN: 0012-821X

hal-00470353
https://hal.archives-ouvertes.fr/hal-00470353
DOI : 10.1016/j.epsl.2010.01.007

Éditeur(s) : HAL CCSD Blackwell Publishing
Résumé : International audience
Pliocene and Pleistocene deposits from Grande-Terre (Guadeloupe archipelago, French Lesser Antilles) provide a remarkable example of an isolated carbonate system built in an active margin setting, with sedimentation both controlled by rapid sea-level changes and tectonic movements. Based on new field, sedimentological and palaeontological analyses, these deposits have been organized into four sedimentary sequences (S1 to S4) separated by three subaerial erosion surfaces (SB0, SB1 and SB2). Sequences S1 and S2 ('Calcaires inférieurs à rhodolithes') deposited during the late Zanclean to early Gelasian (planktonic foraminiferal Zones PL2 to PL5) in low subsidence conditions, on a distally steepened ramp dipping eastward. Red algal-rich deposits, which dominate the western part of Grande-Terre, change to planktonic foraminifer-rich deposits eastward. Vertical movements of tens of metres were responsible for the formation of SB0 and SB1. Sequence S3 ('Formation volcano-sédimentaire', 'Calcaires supérieurs à rhodolithes' and 'Calcaires à Agaricia') was deposited during the late Piacenzian to early Calabrian (Zones PL5 to PT1a) on a distally steepened, red algal-dominated ramp that changes upward into a homoclinal, coral-dominated ramp. Deposition of Sequence S3 occurred during a eustatic cycle in quiet tectonic conditions. Its uppermost boundary, the major erosion surface SB2, is related to the Cala1 eustatic sea-level fall. Finally, Sequence S4 ('Calcaires à Acropora') probably formed during the Calabrian, developing as a coral-dominated platform during a eustatic cycle in quiet tectonic conditions. The final emergence of the island could then have occurred in late Calabrian times.
ISSN: 1469-3496

hal-00760906
https://hal.archives-ouvertes.fr/hal-00760906
DOI : 10.1111/j.1365-3091.2011.01311.x

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The increased expression of the Disintegrin and Metalloprotease ADAM12 has been associated with human cancers, however its role remain unclear. We have previously reported that ADAM12 expression is induced by the transforming growth factor, TGF-β and promotes TGF-β-dependent signaling through interaction with the type II receptor of TGF-β. Here we explore the implication of ADAM12 in TGF-β-mediated epithelial to mesenchymal transition (EMT), a key process in cancer progression. We show that ADAM12 expression is correlated with EMT markers in human breast cancer cell lines and biopsies. Using a non-malignant breast epithelial cell line (MCF10A), we demonstrate that TGF-β-induced EMT increases expression of the membrane-anchored ADAM12L long form. Importantly, ADAM12L overexpression in MCF10A is sufficient to induce loss of cell-cell contact, reorganization of actin cytoskeleton, up-regulation of EMT markers and chemoresistance. These effects are independent of the proteolytic activity but require the cytoplasmic tail and are specific of ADAM12L since overexpression of ADAM12S failed to induce similar changes. We further demonstrate that ADAM12L-dependent EMT is associated with increased phosphorylation of Smad3, Akt and ERK proteins. Conversely, inhibition of TGF-β receptors or ERK activities reverses ADAM12L-induced mesenchymal phenotype. Together our data demonstrate that ADAM12L is associated with EMT and contributes to TGF-β-dependent EMT by favoring both Smad-dependent and Smad-independent pathways
ISSN: 1932-6203

hal-01207281
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207281
DOI : 10.1371/journal.pone.0139179
PUBMED : 26407179

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Late Jurassic coral reefs are present in the Western High Atlas of Morocco along the eastern paleomargin of the young Atlantic Ocean. The Izwarn section shows two reef units made of scleractinian corals and microbialites, included in a progradational shallowing-upward succession. Changes in reefal composition and structure observed in a ca. 50 cm-thick interval at the base of the reef unit 1 are interpreted to represent the first well-documented ecological succession in Late Jurassic reefs. Bioclastic deposits, sparse and poorly diversified corals (five genera) preserved in life position, and finally a more diversified coral assemblage (11 genera) building a reef framework with stromatolitic crusts reflect pioneer, colonization and diversification stages, respectively. A specific depth window, where light was reduced but sufficient for a catch-up growth mode and below the erosive action of waves, probably at the lower slope of a fore-reef area, has made possible the development and the record of this ecological succession. With a more diversified coral assemblage (16 genera), the reef unit 2 reflects shallower and well-agitated waters of a fore-reef area. Overlaying this second reef unit, the upper part of the section reveals back-reef deposits made of reworked reef elements, whereas a putative reef crest area is not recorded.
ISSN: 0016-6995

hal-00795549
https://hal.archives-ouvertes.fr/hal-00795549
DOI : 10.1016/j.geobios.2012.05.002

Éditeur(s) : Société des Sciences Naturelles de la Charente-Maritime
Résumé : The authors give data on the catches during 1991 of some rare fishes to the French harbours : some fishes are recorded for the first time: Dibranchus atlanticus from the North-eastern Atlantic, Paralepis atlantica and Seriola rivoliana from the Baya of Biscay, Lepidocybium flavobrunneum from the statistical ICES Division 8 E. With the growth of the net-fishing for tunna, some pelagic rare species (Taractes asper; Luvarus imperialis, Istiophorid fishes are caught. Tetragonurus cuvieri is recorded for the second time from the Bay of Biscay. NOT CONTROLLED OCR
En 1991, les auteurs ont observé des poissons rares dans les ports français de l'Atlantique. Certains sont signalés pour la première fois dans les zones de capture concernées: Dibranchus atlanticus dans l'Atlantique nord-est, Paralepis atlantica et Seriola rivoliana dans le golfe de Gascogne, Lepidocybium flavobrunneum dans la zone CIEM Large Gascogne. Avec le développement de la pêche au thon au filet, des espèces pélagiques rares (Taractes asper; Luvarus imperialis, des lstiophoridés) ont été également observées. Tetragonurus cuvieri est signalé pour la seconde fois dans le golfe de Gascogne. OCR NON CONTROLE
Annales de la Société des Sciences Naturelles de la Charente-Maritime (Société des Sciences Naturelles de la Charente-Maritime), 1992 , Vol. 8 , N. 1 , P. 51-57

Droits : 1992 Société des Sciences Naturelles de la Charente-Maritime
http://archimer.ifremer.fr/doc/1992/publication-3683.pdf
http://archimer.ifremer.fr/doc/00000/3683/

Éditeur(s) : HAL CCSD
Résumé : International audience
INTRODUCTION: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is characterized by imaging features consisting of the association of centrilobular and/or paraseptal emphysema and pulmonary fibrosis. Virtually all patients are smokers and thus at high risk of developing lung cancer. METHODS: This retrospective multicentre study was conducted by the Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P). RESULTS: A total of 47 patients presenting with lung cancer and CPFE syndrome were identified. All patients were smokers, with a mean of 47 pack-years. A pathological diagnosis of lung cancer was obtained for 38 (81%) patients. Histological type was squamous cell carcinoma in 17 (36%) patients, adenocarcinoma in 14 (30%), non-small-cell lung cancer not otherwise specified in three (6%), small-cell lung cancer in three (6%), and sarcomatoid carcinoma in one (2%). Overall, 20 of the 47 patients could not receive standard-of-care treatment for lung cancer, as per international recommendations or guidelines; this limitation was considered to be directly related to the CPFE syndrome in eight (40%) cases. CONCLUSION: Lung cancer in patients with CPFE syndrome represents a specific entity with a poor prognosis, that further represents the most characteristic and severe model of tobacco-related disease.
Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer

hal-01063912
https://hal.archives-ouvertes.fr/hal-01063912
DOI : 10.1097/JTO.0000000000000209
PUBMED : 25157769