Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé :  
We explored the relationship between soil processes, estimated through soil respiration (Rsoil), and the spatial variation in forest structure, assessed through the distribution of tree size, in order to understand the determinism of spatial variations in Rsoil in a tropical forest. The influence of tree size was examined using an index (Ic) calculated for each tree as a function of (1) the trunk cross section area and (2) the distance from the measurement point. We investigated the relationships between Ic and litterfall, root mass and Rsoil, respectively. Strong significant relationships were found between Ic and both litterfall and root mass. Rsoil showed a large range of variations over the 1-ha experimental plot, from 1.5 to 12.6 gC m−2 d−1. The best relationship between Ic and Rsoil only explained 17% of the spatial variation in Rsoil. These results support the assumption that local spatial patterns in litter production and root mass depend on tree distribution in tropical forests. Our study also emphasizes the modest contribution of tree size distribution-which is mainly influenced by the presence of the biggest trees (among the large range size of the inventoried trees greater than 10 cm diameter at 1.30 m above ground level or at 0.5 m above the buttresses)-in explaining spatial variations in Rsoil.
Plant and Soil

hal-01032200
https://hal.archives-ouvertes.fr/hal-01032200
DOI : 10.1007/s11104-011-0848-1

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
Tight control of basal cytosolic Ca(2+) concentration is essential for cell survival and to fine-tune Ca(2+)-dependent cell functions. A way to control this basal cytosolic Ca(2+) concentration is to regulate membrane Ca(2+) channels including store-operated Ca(2+) channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca(2+) channels involved. It is well accepted that, in response to cell stimulation, opening of these Ca(2+) channels contributes to Ca(2+) entry and the transient increase in cytosolic Ca(2+) concentration involved in intracellular signaling. However, in various experimental conditions, Ca(2+) entry and/or Ca(2+) currents can be recorded at rest, without application of any experimental stimulation. This led to the proposition that some plasma membrane Ca(2+) channels are already open/activated in basal condition, contributing therefore to constitutive Ca(2+) entry. This article focuses on direct and indirect observations supporting constitutive activity of channels belonging to the Orai and TRP families and on the mechanisms underlying their basal/constitutive activities.
ISSN: 0175-7571

hal-01528591
https://hal.archives-ouvertes.fr/hal-01528591
DOI : 10.1007/s00249-017-1216-8
PUBMED : 28516266

Éditeur(s) : HAL CCSD Springer Verlag (Germany) Springer Verlag
Résumé : International audience
Peridotite xenoliths erupted by alkali basaltic volcanoes in the western Pannonian Basin can be divided into two fundamentally contrasting groups. Geochemical characteristics of the abundant protogranular, porphyroclastic and equigranular nodules suggest that these samples originate from an old consolidated and moderately depleted lithospheric mantle domain. In contrast, the geochemical features of the worldwide rare, but in the Pannonian Basin relatively abundant, poikilitic xenoliths attest to a more complex evolution. It has been argued that the origin of the peculiar texture and chemistry may be intimately linked to melt/rock reactions at successively decreasing liquid volumes in a porous melt flow system. The most likely site where such reactions can take place is the asthenosphere-lithosphere boundary. In this context, poikilitic xenoliths may provide petrological and geochemical evidence for reactions between magmatic liquids issued from the uprising asthenosphere and the solid mantle rocks of the lithosphere. These reactions are important agents of the thermal erosion of the lithosphere; thus, they could have considerably contributed to the thinning of the lithosphere in the Pannonian region. We suggest that in the Pannonian Basin, there could be a strong relation between the unusual abundance of poikilitic mantle xenoliths and the strongly eroded lithosphere.
ISSN: 0010-7999

hal-01107421
https://hal.archives-ouvertes.fr/hal-01107421
DOI : 10.1007/s00410-014-1054-y

Éditeur(s) : HAL CCSD Springer Verlag (Germany) Springer Verlag
Résumé : International audience
We report here U-series and trace element data for an olivine-melilitite lava flow, erupted in 1957 in the Virunga volcanic field and known as the Mugogo eruption. Petrological and geochemical data show that the Mugogo magma represents a primary mantle melt, derived from a low degree of melting of a metasomatised mantle source. It is highly enriched in very incompatible trace elements (e.g. more than 300-fold compared to primitive mantle for Th), with a distinctly lower enrichment in Rb, Ba and Sr. The high Th/U and low (230Th/232Th) ratios (4.4 and 0.750, respectively, with a (230Th/238U) ratio of 1.09) are close to the values found for the Nyamuragira basanites. But the most striking feature is the very low (226Ra/230Th) ratio of 0.48, the lowest ever measured in a mafic volcanic rock. The most probable origin of this Ra deficit is the presence of phlogopite (having a high Ra partition coefficient) in the lithospheric mantle, either as a residual phase during low-degree isobaric melting (in batch-melting or a diffusion-controlled melting models), or in a phlogopite-bearing upper mantle through which the melt migrates and equilibrates (in an equilibrium porous flow model commonly used to describe adiabatic melting). The disequilibrium pattern (230Th) > (238U) > (210Pb) ≫ (226Ra), reversed compared to the pattern observed in the Oldoinyo Lengai natrocarbonatite, suggests that a carbonatite melt might have been involved to explain the Ra deficit. We thus discuss the possibility of an early separation of a Ra-enriched carbonate melt either from the olivine-melilitite melt or from a carbonated mantle source, followed by the production of a low-degree melt of olivine-melilitite composition, but the lack of available experimental, petrological and geochemical evidences makes this process somewhat speculative at present. Further studies of recent (<5 ky) olivine-melilitites are needed to check whether the large Ra deficit is a general characteristic of this type of magma that can be used to constrain models of its formation.
ISSN: 0010-7999

hal-01174173
https://hal.archives-ouvertes.fr/hal-01174173
DOI : 10.1007/s00410-015-1124-9

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé :  
We present a plant trait database covering autecology for rain forest trees of French Guiana. The database comprises more than thirty traits including autecology (e.g., habitat associations and reproductive phenology), wood structure (e.g., density and tension characteristics) and physiology at the whole plant (e.g., carbon and nitrogen isotopes) and leaf level (e.g., specific leaf area, photosynthetic capacity). The current database describes traits for about nine hundred species from three hundred genera in one hundred families. For more than sixty species, data on twelve morphological and ecophysiological traits are provided for individual plants under different environmental conditions and at different ontogenetic stages. The database is thus unique in permitting intraspecific analyses, such as the effects of ontogenetic stages or environmental conditions on trait values and their relationships.
Annals of Forest Science

hal-01032196
https://hal.archives-ouvertes.fr/hal-01032196
DOI : 10.1051/forest:2007058

Éditeur(s) : HAL CCSD Springer Verlag (Germany) Springer Verlag
Résumé : Dehydration reactions result in minerals’ replacement and a transient fluid-filled porosity. These reactions involve interface-coupled dissolution–precipitation and might therefore lead to fixed crystallographic orientation relations between reactant (protolith) and product phases (i.e. topotaxy). We investigate these two phenomena in the dehydration of a foliated antigorite (atg) serpentinite by comparing the crystallographic preferred orientation (CPO) developed by olivine (ol), orthopyroxene (opx) and chlorite (chl) during high-pressure antigorite and chlorite dehydration in piston-cylinder experiments and in natural samples recording the dehydration of antigorite (Cerro del Almirez, Betic Cordillera, Spain). Experiments were performed under undrained conditions resulting in fluid-filled porosity and in strong CPO of the prograde minerals, controlled by the pre-existing antigorite CPO in the reactant foliated serpentinite. The orientation of a ol,opx and c∗chl is parallel to c∗atg from the protolith. The Cerro del Almirez samples show similar, locally well-developed topotactic relations between orthopyroxene, chlorite and antigorite, but the product CPOs are weaker and more complex at the thin section scale. In contrast to the experiments, olivine from natural samples shows a weak correlation between b ol and the former c∗atg. We relate the strengthening of local topotactic relations and the weakening of the inherited CPO at a larger scale in natural samples to compaction and associated fluid migration. Microstructural features that might be related to compaction in the natural samples include: (1) smooth bending of the former foliation, (2) gradual crystallographic misorientation (up to 16°) of prismatic orthopyroxene due to buckling by dislocation creep, (3) inversion of enstatite to low clinoenstatite (P21/c) along lamellae and (4) brittle fracturing of prismatic orthopyroxene enclosed by plastically deformed chlorite. The coexistence of orthopyroxene buckling and clinoenstatite lamellae enables estimating the local strain rates and shear stresses generated during compaction. An lower bound for the strain rates in the order of 10−12 to 10−13 s−1 and shear stresses of 60–70 MPa are estimated based on creep data. Lower shear stresses (20–40 MPa) are retrieved using a theoretical approach. These data point to slow compaction (and fluid extraction) in nature if the system is not perturbed by external forces, with rates only marginally higher than the viscoplastic deformation of the solid matrix.
ISSN: 0010-7999

hal-01174158
https://hal.archives-ouvertes.fr/hal-01174158
DOI : 10.1007/s00410-015-1129-4

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
A hybrid linear ion-trap Fourier-transform ion cyclotron resonance mass spectrometer was used for top-down characterization of the abundant human salivary Cystatins, including S, S1, S2, SA, SN, C, and D, using collisionally activated dissociation (CAD) after chromatographic purification of the native, disulfide intact proteins from saliva. Post-translational modifications and protein sequence polymorphisms arising from single nucleotide polymorphisms (SNPs) were assigned from precursor and product ion masses at a tolerance of 10 ppm allowing confident identification of individual intact mass tags. Cystatins S, S1, S2, SA and SN were cleaved of a N-terminal 20 amino-acid signal peptide, and Cystatin C a 26-residue peptide, to yield a generally conserved N-terminus. In contrast, Cystatin D isoforms with 24 and 28 amino-acid residue N-terminal truncations were found such that their N-termini were not conserved. Cystatin S1 was phosphorylated at Ser3, while S2 was phosphorylated at Ser1 and Ser3 of the mature protein, in agreement with previous work. Both Cystatin D isoforms carried the polymorphism C46R (SNP: rs1799841). The 14328 Da isoform of Cystatin SN previously assigned with polymorphism P31L due to a SNP (rs2070856) was found only in whole saliva. Parotid secretions contained no detectable Cystatins while whole saliva largely mirrored the contents of submandibular/sublingual (SMSL) secretions. Top-down high-resolution mass spectrometry is a powerful tool for the identification and characterization of potential protein biomarkers in saliva.
ISSN: 1044-0305

hal-00677483
https://hal.archives-ouvertes.fr/hal-00677483
DOI : 10.1016/j.jasms.2010.01.025

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
The Michaelis-Menten enzymatic reaction is sufficient to perceive many subtleties of network modeling, including the concentration and time scales separations, the formal equivalence between bulk phase and single-molecule approaches, or the relationships between single-cycle transient probabilities and steady state rates. Twelve methods proposed by different authors and yielding the same famous Michaelis-Menten equation, are selected here to illustrate the kinetic and probabilistic use of rate constants and to review basic techniques for handling them. Finally, the general rate of an ordered multistep reaction, of which the Michaelis-Menten reaction is a particular case, is deduced from a Markovian approach.
ISSN: 0259-9791

hal-00920806
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920806
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920806v2/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920806/file/12MM.pdf
ARXIV : 1312.5468

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
Naegleria fowleri is found in most geothermal baths of Guadeloupe and has been responsible for the death of a 9-year-old boy who swam in one of these baths in 2008. We wanted to determine the origin for the presence of this amoeba in the water.Water samples were taken at the origin of the geothermal sources and at the arrival in the baths. After filtration, cultures were made and the number of Naegleria present was determined using the most probable number method. Soil samples collected in the proximity of the baths were also tested for the presence of thermophilic amoebae. The species identification was obtained by PCR. During three consecutivemonths, no Naegleria could be found at the origin of any geothermal source tested. In contrast, N. fowleri was isolated at least once in all baths at the arrival of the water, except one. Thermophilic amoebae could be found in each soil sample, especially near the baths located at a lower altitude, but N. fowleri was only isolated near two baths, which were also the baths most often contaminated with this species. So it appears that the contamination of the water with N. fowleri occurs after emerging from the geothermal source when the water runs over the soil. Therefore, it should be possible to reduce the concentration of N. fowleri in thegeothermal baths of Guadeloupe to for example less than 1 N. fowleri/10 L by installing a pipeline between the geothermal sources and the baths and by preventing flooding water from entering the baths after rainfall. By taking these measures, we were able to eliminate N. fowleri from a poollocated inside a reeducation clinic.
ISSN: 0932-0113

pasteur-01136739
https://hal-riip.archives-ouvertes.fr/pasteur-01136739
DOI : 10.1007/s00436-014-4197-x.
PUBMED : 25352239

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
*Context Increased knowledge on diversity in wood properties would have implications both for fundamental research and for promoting a diversification of uses as material. *Aims The objective is to contribute to overcoming the critical lack of data on the diversity of wood dynamic mechanical/viscoelastic vibrational properties, by testing lesser-known species and categorizing sources of variability. *Methods Air-dry axial specific dynamic modulus of elasticity (E'/γ) and damping coefficient (tanδ) were measured on a wide sampling (1792 specimens) of 98 wood types from 79 species. An experimental device and protocol was designed for conducting systematic (i.e. rapid and reproducible) characterizations. *Results Diversity at the specimens' level corroborates the "standard" relationship between tanδ and E'/γ, which is discussed in terms of orientation of wood elements and of chemical composition. Diversity at the species level is expressed on the basis of results for normal heartwood, with specific gravity (γ) ranging from 0.2 to 1.3. Axial E'/γ ranges from 9 to 32 GPa and tanδ from 4×10-3 to 19×10-3. Properties distribution follows a continuum, but with group characteristics. The lowest values of tanδ are only found in certain tropical hardwoods. Results can also suggest alternative species for musical instruments making.
Annals of Forest Science

hal-00808242
https://hal.archives-ouvertes.fr/hal-00808242
https://hal.archives-ouvertes.fr/hal-00808242/document
DOI : 10.1007/s13595-011-0166-z

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : In this paper we study merosity in the genus Urospatha within the framework of a resolved phylogeny of the Araceae. We analyse how a transition from dimerous or tetramerous merosity to pentamerous or hexamerous merosity can occur developmentally in the Lasioideae. In Urospatha, initiation of floral primordia along the inflorescence is acropetal, while development of flowers is basipetal. This indicates the presence of two distinct phases in the development of the Urospatha inflorescence. The first phase corresponds to initiation of flowers and establishment of the phyllotactic pattern, and the second phase to differentiation of floral organs. Urospatha is characterized by the presence of trimerous, tetramerous, pentamerous and rarely hexamerous flowers. In all types of flowers, the stamens are closely associated and opposite to the tepals. Pentamerous flowers are formed by addition of a sector comprising a stamen and tepal. Likewise, in the case of hexamerous flowers, two sectors are added. In the Lasioideae, the increase in the number of tepals and stamens is linked with two developmental processes that have appeared independently in the subfamily: (1) addition of one or two stamen-petal sectors (Anaphyllopsis and Urospatha), and (2) independent increase in the number of tepals and stamens on whorls, more or less organized and inserted in alternate position (Dracontium). Tetramerous whorls as they occur in basal Lasioideae would be homologous to two dimerous whorls from an evolutionary point of view.
ISSN: 0378-2697

hal-01019867
https://hal.archives-ouvertes.fr/hal-01019867
DOI : 10.1007/s00606-011-0475-6

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
Environmental Science and Pollution Research

hal-01110873
https://hal.archives-ouvertes.fr/hal-01110873
DOI : 10.1007/s11356-014-3272-2

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : 5 pages
International audience
This study investigates the recent evolution of a rich parasite community associated with one of the world's most invasive species, the cichlid fish Oreochromis mossambicus. Populations from the species' native range (Mozambique) are compared to a population from New Caledonia (Wester Pacific), an island where the species was introduced in 1954. The results support the complete local extinction of the gill parasite community in the course of the invasion process. Up to six gill parasite species per locality were documented in the O. mossambicus native range, and previous surveys consistently reported at least one parasite species introduced along African cichlid species established out of Africa. The absence of parasites in New Caledonia is therefore exceptional. This can be attributed to local factors, such as a strong initial population bottleneck, the likely absence of multiple host introductions, and the frequent occurrence of brackish watersheds that might enhance the probability for natural deparasitation.
ISSN: 0932-0113

hal-01356378
https://hal.archives-ouvertes.fr/hal-01356378
PUBMED : 27334451
DOI : 10.1007/s00436-016-5168-1

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
Today, there is increasing concern regarding the capacity ofScleractinian corals to sustain the growing number of insultsassociated with global and local changes (e.g. global warming,ocean acidification, pollution). If corals are to exist, there is anurgent need to use indicators of coral health that provide insightinto early sub lethal shifts in corals before the irreversibleeffects of exposure manifest at the population and communitylevels. This paper will provide an overview of the most relevantand appropriate indicators of coral health currently usedin traditional monitoring programs (traditional approach) orthose that could be used in a near future to improve assessmentof coral health (new and proactive approach). In addition, byusing French Polynesia coral reefs as a study case, this paperwill present how coral health was assessed in the past and howit will be in a near future.
ISSN: 0948-4280

hal-01342777
https://hal-univ-perp.archives-ouvertes.fr/hal-01342777
DOI : 10.6119/JMST-013-0813-2

Éditeur(s) : HAL CCSD Springer Verlag (Germany) Springer Verlag
Résumé : Dihydroceramide ?4-desaturase 1 (DES1) catalyzes the last step of the de novo ceramide biosynthesis, which consists of the introduction of a trans ?4-double bond in the carbon chain of the dihydroceramide. It was previously observed that myristic acid binds DES1 through N-myristoylation. This N-terminal modification significantly increased the activity of the recombinant DES1 in COS-7 cells and targeted part of the enzyme initially present in the endoplasmic reticulum to the mitochondrial outer membrane, leading to an increase in ceramide levels. Since these results were obtained in a recombinant COS-7 cell model with high expression of rat DES1, the purpose of the present study was to investigate if the native DES1 enzyme was really upregulated by its N-myristoylation in cultured rat hepatocytes. We first showed that DES1 was the main dihydroceramide desaturase isoform expressed in rat hepatocytes. In this model, the wild-type myristoylable recombinant form of rat DES1 was found in both the endoplasmic reticulum and the mitochondria whereas the mutated non-myristoylable recombinant form (N-terminal glycine replaced by an alanine) was almost exclusively localized in the endoplasmic reticulum, which evidenced the importance of the myristoylation. Then, we showed that compared to other fatty acids, myristic acid was the only one to increase native DES1 activity, in both total cell lysates and mitochondrial fractions. The myristic acid-associated increase in DES1 activity was not linked to elevated mRNA or protein expression but more likely to its N-terminal myristoylation. Finally, the myristic acid-associated increase in DES1 activity slightly enhanced the number of apoptotic cells.
ISSN: 0024-4201

hal-00808026
https://hal-agrocampus-ouest.archives-ouvertes.fr/hal-00808026
DOI : 10.1007/s11745-011-3638-x

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
The Michaelis-Menten enzymatic reaction is sufficient to perceive many subtleties of network modeling, including the concentration and time scales separations, the formal equivalence between bulk phase and single-molecule approaches, or the relationships between single-cycle transient probabilities and steady state rates. Seven methods proposed by different authors and yielding the same famous Michaelis-Menten equation, are selected here to illustrate the kinetic and probabilistic use of rate constants and to review basic techniques for handling them. Finally, the general rate of an ordered multistep reaction, of which the Michaelis-Menten reaction is a particular case, is deduced from a Markovian approach.
Journal of Mathematical Chemistry

hal-00920806
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920806
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920806/document
ARXIV : 1312.5468
DOI : 10.1007/s10910-013-0237-5

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : We present a detailed rock-magnetic and archaeomagnetic study of two brick kilns, named OSA and OSB, discovered at the location of Osterietta, in northern Italy. The magnetic properties of representative samples have been investigated to identify the nature of the magnetic carriers, their domain state and thermal stability, and investigate their suitability for archaeomagnetic determinations. Thermally stable, mainly pseudosingle domain (PSD) magnetite is identified as the main magnetic carrier. The full geomagnetic field vector has been determined for the two kilns, including directional and intensity analysis. Archaeointensities have been recovered with both the classical Thellier and the multi-specimen protocols. The multi-specimen procedure was performed with a very fast-heating oven developed at Montpellier, France. A Matlab® code for anisotropy correction during the Thellier experiment is provided. The archaeointensity results obtained from both techniques for the OSA kiln are of high quality and in good mutual agreement. For the OSB kiln, Thellier results are characterized by large standard deviation and the multi-specimen (MSP) technique was not successful. The obtained full geomagnetic field vector (declination, inclination and intensity) has been used for the archaeomagnetic dating of the two structures suggesting that the OSA kiln was for the last time used between 1761?1841 A.D. and the OSB kiln between 1752?1831 A.D., at 95% probability. This study shows that intensity determinations do not restrict the dating results when referring to the last few centuries, as this period is characterized by very small intensity variations.
ISSN: 0039-3169

hal-01236052
https://hal.archives-ouvertes.fr/hal-01236052
DOI : 10.1007/s11200-015-0413-0

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
Myrmecophytic symbioses are widespread in tropical ecosystems and their diversity makes them useful tools for understanding the origin and evolution of mutualisms. Obligate ant-plants, or myrmecophytes, provide a nesting place, and, often, food to a limited number of plant-ant species. In exchange, plant-ants protect their host plants from herbivores, competitors and pathogens, and can provide them with nutrients.
Oecologia

hal-00955375
https://hal.archives-ouvertes.fr/hal-00955375
https://hal.archives-ouvertes.fr/hal-00955375/document
DOI : 10.1007/s00442-010-1739-5
OATAO : 11094

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : absent
Oecologia

hal-01032392
https://hal.archives-ouvertes.fr/hal-01032392
DOI : 10.1007/s00442-011-1966-4

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
Tight control of basal cytosolic Ca2+ concentration is essential for cell survival and to fine-tune Ca2+-dependent cell functions. A way to control this basal cytosolic Ca2+ concentration is to regulate membrane Ca2+ channels including store-operated Ca2+ channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca2+ channels involved. It is well accepted that, in response to cell stimulation, opening of these Ca2+ channels contributes to Ca2+ entry and the transient increase in cytosolic Ca2+ concentration involved in intracellular signaling. However, in various experimental conditions, Ca2+ entry and/or Ca2+ currents can be recorded at rest, without application of any experimental stimulation. This led to the proposition that some plasma membrane Ca2+ channels are already open/activated in basal condition, contributing therefore to constitutive Ca2+ entry. This article focuses on direct and indirect observations supporting constitutive activity of channels belonging to the Orai and TRP families and on the mechanisms underlying their basal/constitutive activities.
ISSN: 0175-7571

inserm-01526286
http://www.hal.inserm.fr/inserm-01526286
http://www.hal.inserm.fr/inserm-01526286/document
http://www.hal.inserm.fr/inserm-01526286/file/EBJO-D-16-00056_R1-2%20%282%29.pdf
PUBMED : 28516266