Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : CCBY
National audience
ISSN: 0761-8425

hal-01117879
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117879
PUBMED : 24314711
DOI : 10.1016/j.rmr.2013.09.007

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BACKGROUND:Sickle cell anaemia (SCA) is a severe hereditary haemoglobinopathy characterised by haemorheological abnormalities, which play a role in the occurrence of several acute and chronic clinical complications. While βS -haplotypes and alpha-thalassaemia modulate SCA clinical severity, their effects on blood rheology have been incompletely described. The aim of this study was to test the effects of these genetic modifiers on the haemorheological properties and clinical complication of children with SCA.PROCEDURE:Steady-state haemorheological profile, biological parameters, βS -haplotypes, alpha-globin status, vaso-occlusive crisis (VOC) and acute chest syndrome frequencies were analysed in 128 children (aged 5 to 18 years) with SCA.RESULTS:Patients with alpha-thalassaemia showed increased red blood cell (RBC) deformability and aggregation compared to those without. Median VOC rate was higher in patients with homozygous alpha-thalassaemia compared to those with a normal alpha genotype. Conversely, the haemorheological profile and clinical complications were not influenced by the βS -haplotypes in our study.CONCLUSION:Our results demonstrate that alpha-thalassaemia is associated with higher risk for VOC events in children with SCA, which may be due in part to its effects on RBC deformability and aggregation.
ISSN: 1545-5009

hal-01668317
https://hal.univ-antilles.fr/hal-01668317
DOI : 10.1002/pbc.26455
PUBMED : 28097791

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The morphogenetic evolution of the Lesser Caucasus has been strongly influenced by Plio-Quaternary volcanic and tectonic events and Pleistocene glaciations. Fluvio-lacustrine environments, indicated by diatomaceous deposits, prevailed in the Syunik region of southern Armenia during the Pliocene and Pleistocene. The Pleistocene diatomaceous deposits studied contain leaf impressions and pollen, allowing local palaeoclimatic reconstructions. The chronology of morphogenetic events has been determined by 17 radiometric dates (K/Ar, Ar/Ar, U/Th), palaeomagnetic investigations and is placed in a spatial context by a detailed geomorphological map and a 24-km geological transect of the Vorotan valley, the main area studied. Before 1.21 Ma, tectonic movements (antecedents of the lower part of the Vorotan valley) generated extensive lake formations with diatomaceous deposits. From 993 ka, volcanic eruptions produced lava flows that covered the fluvio-lacustrine accumulations. During Marine Isotopic Stages 12, 6 and 4, glaciers and fluvio-glacial deposits were probably present overall the principal uplands and valleys of southern Armenia. At 53.68 ka (MIS 3), 12.6 ka, 10.78 ka and 4.14 ka (MIS 1), the development of travertines on some slopes and in some valleys highlights temperate and humid climatic phases. Palaeobotanical studies of leaf and pollen floras show that the vegetation changed several times from forested to steppic phases in response to the climate oscillations of the Lower Pleistocene. This work proposes a first morphogenic and palaeoclimatic reconstruction from the lower Pleistocene to the Postglacial period, when the first settlements of the population in the Lesser Caucasus were influenced by tectono-volcanic events, lake level changes and glacialeinterglacial oscillations forced by the obliquity orbital parameter (41 ky cycles).
ISSN: 1040-6182

hal-00481939
https://hal.archives-ouvertes.fr/hal-00481939
DOI : 10.1016/j.quaint.2010.02.008

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
OBJECTIVE:To identify local meteorological drivers of dengue fever in French Guiana, we applied an original data mining method to the available epidemiological and climatic data. Through this work, we also assessed the contribution of the data mining method to the understanding of factors associated with the dissemination of infectious diseases and their spatiotemporal spread.METHODS:We applied contextual sequential pattern extraction techniques to epidemiological and meteorological data to identify the most significant climatic factors for dengue fever, and we investigated the relevance of the extracted patterns for the early warning of dengue outbreaks in French Guiana.RESULTS:The maximum temperature, minimum relative humidity, global brilliance, and cumulative rainfall were identified as determinants of dengue outbreaks, and the precise intervals of their values and variations were quantified according to the epidemiologic context. The strongest significant correlations were observed between dengue incidence and meteorological drivers after a 4-6-week lag.DISCUSSION:We demonstrated the use of contextual sequential patterns to better understand the determinants of the spatiotemporal spread of dengue fever in French Guiana. Future work should integrate additional variables and explore the notion of neighborhood for extracting sequential patterns.CONCLUSIONS:Dengue fever remains a major public health issue in French Guiana. The development of new methods to identify such specific characteristics becomes crucial in order to better understand and control spatiotemporal transmission.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
ISSN: 1067-5027

lirmm-01379072
https://hal-lirmm.ccsd.cnrs.fr/lirmm-01379072
DOI : 10.1136/amiajnl-2013-002348
PUBMED : 24549761

Résumé : Le programme d'amélioration des techniques d'élevage de la Chevrette Macrobrachium rosenbergii en Guyane constitue la deuxième phase du programme d'expérimentation mené sur la station IFREMER de Kourou. Jusqu'en 1988, l'effort a porté sur l'analyse du système continu classique utilisé par l'ensemble des producteurs de Macrobrachium aux Antilles et en Guyane. A partir de 1988, il apparut que la résolution des problèmes posés par son application passait par l'utilisation de schémas de gestion de la population en mode discontinu. Les expérimentations ont donc porté sur les principales conditions d'élevage susceptibles d'améliorer l'efficacité du schéma d'exploitation de la population. En prégrossissement, il s'agissait d'obtenir le meilleur compromis densité/croissance en jouant sur des facteurs tels que l'aliment artificiel ou la stimulation de la productivité naturelle, tout en produisant un juvénile pour toute post larve ensemencée. En grossissement, la contrainte essentielle est l'organisation sociale de la population qui se traduit par une croissance rapide et hétérogène des mâles et une croissance lente mais homogène des femelles. Nous avons essayé de dégager les schémas permettant de tirer le maximum de profit de ces spécificités de croissance avec un minimum de coût. Pour cela nous avons testé différentes procédures en jouant sur le poids moyen initial, les caractéristiques de la population introduite (monosexe, lot de tête ou de queue issus d'un tri), la densité et la durée d'élevage,le mode de récolte.

Droits : 1992 Ifremer
http://archimer.ifremer.fr/doc/00041/15262/12611.pdf
http://archimer.ifremer.fr/doc/00041/15262/

Résumé : En 1987, la filière de production de chevrettes Macrobrachium rosenbergii en Guyane Française a fait l'objet d'intervention du laboratoire d'aquaculture de l'IFREMER à 2 niveaux : un appui technique à la profession, et des expérimentations à la station expérimentale gérée en commun par IFREMER et INRA, à KOUROU. L'appui technique a porté sur la formation d'éleveurs notamment pour le démarrage des exploitations, l'amélioration des techniques d'exploitation et de choix des classes détaillées commerciales, la maîtrise des caractéristiques du milieu d'élevage par l'utilisation des amendements classiques, la lutte contre la contamination des produits par les germes coliformes. Le programme de recherche a porté en 1987 sur l'analyse du milieu d'élevage et tenté d'identifier un bon estimateur de la qualité du milieu, nécessaire pour l'exploitation des bassins par la méthode en «continu». Au plan de la production, l'année 1987 est marquée par un arrêt brutal de la dynamique de la production qui caractérisait les années précédentes, en raison de l'échec de la commercialisation à l'exploitation, allant jusqu'à l'arrêt de quatre exploitations représentant une vingtaine d'hectares.

Droits : 1989 Ifremer
http://archimer.ifremer.fr/doc/00041/15267/12619.pdf
http://archimer.ifremer.fr/doc/00041/15267/

Résumé : En 1987, l'analyse du système d'élevage en continu menée par l' IFREMER tant sur les fermes guyanaises que sur la station expérimentale de Kourou a permis de mettre en évidence les limites et les faiblesses de ce mode d'élevage. Elle a montré la nécessité d'un meilleur contrôle du cheptel depuis l'ensemencement jusqu'à la commercialisation afin de pouvoir atteindre de manière fiable des rendements de l'ordre de 2,5 T/ha/an.

Droits : 1990 Ifremer
http://archimer.ifremer.fr/doc/00041/15266/12618.pdf
http://archimer.ifremer.fr/doc/00041/15266/

Éditeur(s) : HAL CCSD
Résumé : International audience
o abstract
Revue Des Maladies Respiratoires

hal-01647079
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647079
DOI : 10.1016/j.rmr.2017.07.019
PUBMED : 28939154

Éditeur(s) : HAL CCSD
18th European Congress of Clinical Microbiology an Infectious Diseases (ECCMID)
Barcelone, Spain

hal-00676899
https://hal.archives-ouvertes.fr/hal-00676899

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0040-1951

hal-00843380
https://hal-mines-paristech.archives-ouvertes.fr/hal-00843380
DOI : 10.1016/j.tecto.2013.05.043

Éditeur(s) : HAL CCSD
Résumé : International audience
Proceedings of the European Symposium on Artificial Neural Networks
Bruges, Belgium

halshs-00410041
https://halshs.archives-ouvertes.fr/halshs-00410041

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Oxidative stress and haemolysis-associated nitric oxide (NO) depletion plays a crucial role in the development of vasculopathy in sickle cell anaemia (SS). However it remains unknown whether oxidative stress and haemolysis levels influence vascular function in patients with sickle haemoglobin C disease (SC). Microvascular response to heat (using Laser Doppler flowmetry on finger), oxidative stress biomarkers, NO metabolites, endothelin-1 and haematological parameters were compared between patients with SS and SC. Vascular function, oxidative and nitrosative markers were also measured in healthy (AA) children. SS and SC had increased plasma advanced oxidation protein products (AOPP), malondialdehyde, plasma antioxidant activities and NO end products, compared to AA. SC had lower catalase activity compared to AA and SS. Haemolytic rate, glutathione peroxidase and nitrotyrosine concentrations were significantly increased in children with SS compared to SC and AA. SS and SC had impaired microvascular reactivity compared to AA. In SS, the plateau phase of the response to local thermal heating was negatively associated with nitrotyrosine and AOPP. No association between vascular function parameters and oxidative stress markers was observed in SC. Mild haemolysis in SC, compared to SS, may limit oxidative and nitrosative stress and could explain the better preserved microvascular function in this group.
ISSN: 0007-1048

hal-01668314
https://hal.univ-antilles.fr/hal-01668314
DOI : 10.1111/bjh.14693

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The chronostratigraphy of the lower Miocene deposits of northwestern Sardinia is refined in the Castelsardo Basin. The combination of new 40Ar/39Ar isotopic datings, 19 micropalaeontological datings (calcareous nannofossils, planktonic and large benthic foraminifers) and 16 palaeomagnetic polarity measurements led to a new chronostratigraphic framework. The continental deposits of the first megasequence (Valledoria and Casteldoria members) are possibly Aquitanian. The overlying marine sediments are early Burdigalian (Vaginella depressa Molasse). The marine transgression can be dated to around 19.7 Ma. Marine conditions ceased 18.83 ± 0.13 Ma, the age of the index aerial τ2 ignimbrite. The continental part of the second megasequence (“Lacustre” unit) is early–middle Burdigalian, between 18.8 and 18 Ma. The overlying marine part (Campulandu and Sedini members) is middle–late Burdigalian. The second marine transgression began in the earliest–late Burdigalian, during the Chron C5Dr reversal, at the time of the eustatic Bur 4 event. The Castelsardo basin went through two main extensional tectonic episodes. The first one occurred as the Valledoria Member was deposited and possibly dates back to the Aquitanian. The second one occurred as the uppermost part of the Vaginella depressa Molasse was deposited during the early Burdigalian. The second extensional episode is related to a rapid rotation of Sardinia. Palaeomagnetic results confirm that Corsica and Sardinia acted as a single block which suffered a 28 ± 17° ccw rotation after 19.2 Ma. The Castelsardo basin is held to be an Aquitanian–early Burdigalian intra-arc rift basin that later evolved in a thermally controlled subsident margin of the Ligurian-Provençal Basin during the middle–late Burdigalian.
ISSN: 0031-0182

hal-00498288
https://hal.archives-ouvertes.fr/hal-00498288
DOI : 10.1016/j.palaeo.2010.06.007

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
The Sivas Basin, located in the Central Anatolian Plateau of Turkey, is a foreland basin that records a complex interaction between sedimentation, salt tectonics and regional shortening during the Oligo-Miocene leading to the formation of numerous mini-basins. The Oligocene sedimentary infill of the mini-basins consists of a thick continental succession, the Karayün Formation, comprising a vertical succession of three main sub-environments: (i) playa-lake, (ii) fluvial braided, and (iii) saline lacustrine. These sub-environments are seen as forming a large Distributive Fluvial System (DFS) modified through time as a function of sediment supply and accommodation related to regional changes in climate and tectonic regime. Within neighbouring mini-basins and despite a similar vertical stratigraphic succession, subtle variations in facies assemblages and thickness are observed in stratigraphic units of equivalent age, thus demonstrating the local control exerted by halokinesis. Stratigraphic and stratal patterns reveal in great detail the complex interaction between salt tectonics and sedimentation including different types of halokinetic structures such as hooks, wedges and halokinetic folds. The regional variations of accommodation/sediment supply led to coeval changes in the architectural patterns recorded in the mini-basins. The type of accommodation regime produces several changes in the sedimentary record: (i) a regime dominated by regional accommodation limits the impact of halokinesis, which is recorded as very small variations in stratigraphic thickness and facies distribution within and between mini-basins; (ii) a regime dominated by localized salt-induced accommodation linked to the subsidence of each individual mini-basin enhances the facies heterogeneity within the DFS, causing sharp changes in stratigraphic thickness and facies assemblages within and between mini-basins.
ISSN: 0950-091X

hal-01685659
https://hal.archives-ouvertes.fr/hal-01685659
DOI : 10.1111/bre.12171

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : International audience
In this paper we present and discuss new investigations performed on both the magmatic basement and the sedimentary formations of La Désirade. We report structural and sedimentary evidences for several episodes of deformation and displacement occurring prior to the present day tectonics. The main faults, respectively N130 ± 10°, N040 ± 10° and N090 ± 10°, previously considered as marker of the current tectonic regime corresponds to reactivated tectonic structures developed first during late Cretaceous compression and second during Pliocene to early Pleistocene extension. We demonstrate also the importance of late Pliocene-early Pleistocene and middle-late Pleistocene vertical movements in this part of the Lesser Antilles fore-arc as well as the role of compressive tectonics in the over thickened character of the arc basement in the Guadeloupe archipelago
EISSN: 1777-5817

hal-00830329
https://hal.archives-ouvertes.fr/hal-00830329
DOI : 10.2113/gssgfbull.184.1-2.21

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
Le premier volet du projet Cyprim vise à mieux identifier les précurseurs des cyclogenèses et des précipitations intenses en région méditerranéenne. Cet article en présente les principaux résultats. Il est question des ingrédients météorologiques à l'origine de ces systèmes, de la grande à la mésoéchelle, des causes des fortes intensités, localisations et parfois stationnarité des récipitations associées. Le coeur de l'article présente des méthodes d'identification des anomalies de tourbillon potentiel liées à l'occurrence d'événements précipitants intenses et dresse une climatologie de ces anomalies. Les perspectives d'exploitation de cette information pour améliorer la qualité des prévisions sont évoquées. ENGLISH VERSION: The first part of the CYPRIM project (Cyclogenesis and intense precipitations in the Mediterranean region) aims at a better identification of the precursor structures of cyclogenesis and heavy precipitation in the Mediterranean region. This article presents the main results. It mentions the meteorological ingredients from which these systems originate from the large to themesoscale, the reasons for large intensities, the localization and sometimes stationarity of the associated precipitations. The heart of the article shows methods for identifiying potential vorticity anomalies involved in the occurrence of heavy precipitation events and sets up a climatology of these anomalies.The perspectives of the usefulness of this information for improving forecast quality are discussed.
ISSN: 0026-1181

insu-00448250
https://hal-insu.archives-ouvertes.fr/insu-00448250
DOI : 10.4267/2042/28828

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Karukéra spur is an easternmost submerged rise of the Lesser Antilles fore-arc in the Guadeloupe archipelago, culminating about 4000 m above the fore-arc basin 150 km west of the deformation front. The analysis of 3500 km 2D high-resolution multichannel seismic reflection and multibeam bathymetric data, and the study of 14 core samples, allow for the first time to reconstruct its sedimentary anatomy and tectonic evolution. Seven seismic units (US1 to US7) are evidenced, organised into four major depositional sequences separated by erosional surfaces. Units US1 to US4 thicken to the south-southeast on the spur. The sedimentary deposits rest upon a deeply eroded metamorphic basement of the Caribbean Plate as in La Désirade Island. Sequence 1 (units US1 and US2) remains unknown in its lower part because it does not outcrop. Its upper part comprises early Miocene shallow water carbonates. Sequence S2 (Unit US3) only comprises an upper Miocene transgressive systems tract deposited into basinal environment. It is bounded by major erosional surfaces SB2 and SB3. Sequence 3 (US4 to US6) is Zanclean to Pleistocene. It is dominantly composed of shallow water, reefal deposits. Sequence 4 corresponds to recent deposits. The Karukéra spur experienced three main extensional episodes with alternations between uplift and subsidence periods. Uplifts are responsible for emersions and erosions. Subsidence severely drowned shallow water deposits. The first extensional episode led to the formation of horsts and grabens in the basement, prior to early Miocene deposits. The second extensional episode occurred during upper Miocene, in accordance with data in surrounding islands. The third tectonic episode developed since Calabrian. Noticeable is the constant reactivation of N130°–N150°, N150°–N180° and N40° trending faults since early Miocene and the neoformation of E–W trending faults since Calabrian. Our results suggest that at the latitude of Guadeloupean archipelago the Lesser Antilles subduction zone is an erosional margin because of the successive sweepings of the Santa Lucia then Tiburon Ridges.
ISSN: 0025-3227

hal-01172231
https://hal.archives-ouvertes.fr/hal-01172231
DOI : 10.1016/j.margeo.2015.02.007

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Treacher Collins/Franceschetti syndrome (TCS; OMIM 154500) is a disorder of craniofacial development belonging to the heterogeneous group of mandibulofacial dysostoses. TCS is classically characterized by bilateral mandibular and malar hypoplasia, downward-slanting palpebral fissures, and microtia. To date, three genes have been identified in TCS:,TCOF1, POLR1D, and POLR1C. We report a clinical and extensive molecular study, including TCOF1, POLR1D, POLR1C, and EFTUD2 genes, in a series of 146 patients with TCS. Phenotype-genotype correlations were investigated for 19 clinical features, between TCOF1 and POLR1D, and the type of mutation or its localization in the TCOF1 gene. We identified 92/146 patients (63%) with a molecular anomaly within TCOF1, 9/146 (6%) within POLR1D, and none within POLR1C. Among the atypical negative patients (with intellectual disability and/or microcephaly), we identified four patients carrying a mutation in EFTUD2 and two patients with 5q32 deletion encompassing TCOF1 and CAMK2A in particular. Congenital cardiac defects occurred more frequently among patients with TCOF1 mutation (7/92, 8%) than reported in the literature. Even though TCOF1 and POLR1D were associated with extreme clinical variability, we found no phenotype-genotype correlation. In cases with a typical phenotype of TCS, 6/146 (4%) remained with an unidentified molecular defect.
ISSN: 1098-3600

hal-01134364
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134364
DOI : 10.1038/gim.2015.29
PUBMED : 25790162

Éditeur(s) : HAL CCSD American Society for Investigative Pathology
Résumé : International audience
Recent studies suggest that psoriasis may be more severe in patients with nonalcoholic fatty liver disease, particularly in those with the inflammatory stage of steatohepatitis [nonalcoholic steatohepatitis (NASH)]. Herein, we investigated the impact of diet-induced steatohepatitis on the severity of imiquimod-induced psoriasiform dermatitis. Mice fed with a high-fat diet developed steatohepatitis reminiscent of human NASH with ballooning hepatocytes and significant liver fibrosis. Mice with steatohepatitis also displayed moderate cutaneous inflammation characterized by erythema, dermalinfiltrates of CD45(+) leukocytes, and a local production of IL-17A. Moreover, steatohepatitis was associated with an epidermal activation of caspase-1 and cutaneous overexpression of IL-1 beta. Imiquimod-induced psoriasiform dermatitis was exacerbated in mice with steatohepatitis as compared to animals fed with a standard diet. Scale formation and acanthosis were aggravated, in correlation with increased IL-17A and IL-22 expression in inflamed skins. Finally, intradermal injection of IL-17A in standard diet-fed mice recapitulated the cutaneous pathology of mice with steatohepatitis. The results show that high-fat diet induced steatohepatitis aggravates the inflammation in psoriasiform dermatitis, via the cutaneous production of IL-17A. In agreement with clinical data, this description of a novel extrahepatic manifestation of NASH should sensitize dermatologists to the screening and the management of fatty liver in psoriatic patients.
ISSN: 0002-9440

hal-01390977
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390977
DOI : 10.1016/j.ajpath.2016.05.012
PUBMED : 27423696

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study aimed to identify factors associated with virological response (VR) to raltegravir (RAL)-containing regimens in 468 treatment-experienced but integrase inhibitor-naive HIV-1 patients receiving a RAL-containing regimen. VR was defined at Month 6 (M6) as HIV-1 RNA viral load (VL) <50 copies/mL. The impacts on VR of baseline integrase mutations, VL, CD4 count, genotypic sensitivity score for nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors, and the number of new antiretrovirals used for the first time associated with RAL were investigated. For patients with VL >50 copies/mL at M6, integrase mutations selected were characterised. Median baseline VL was 4.2 log(10)copies/mL (IQR 3.3-4.9 log(10) copies/mL) and CD4 count was 219 cells/mm(3) (IQR 96-368 cells/mm(3)). At M6, 71% of patients were responders. In multivariate analysis, baseline VL and CD4 count and ≥ 2 new antiretrovirals among darunavir, etravirine, maraviroc and enfuvirtide were associated with VR to RAL. Neither HIV-1 subtype nor baseline integrase polymorphisms were associated with VR to RAL. Among 63 failing patients at M6, selection of ≥ 1 change in the integrase gene was observed in 49 (77.8%), and 27/63 (42.9%) were considered as RAL-associated resistance mutations. Factors independently associated with the occurrence of ≥ 1 RAL-associated resistance mutation were VL at failure >3 log(10) and having no new drugs associated with RAL. RAL showed great potency in treatment-experienced patients. The number of new drugs associated with RAL was an important factor associated with VR. HIV-1 subtype and baseline integrase polymorphisms do not influence the RAL VR.
ISSN: 0924-8579

hal-00875083
https://hal.archives-ouvertes.fr/hal-00875083
DOI : 10.1016/j.ijantimicag.2013.02.016
PUBMED : 23562640