Éditeur(s) : HAL CCSD Wiley-VCH Verlag
Résumé : International audience
Saccharopolyspora rectivirgula is the principal cause of farmer's lung disease (FLD). Serodiagnosis is based on immunoprecipitation techniques or enzyme immunoassays with homemade crude antigens and is not standardized. We aimed to produce specific recombinant antigens for the development of a standardized ELISA. We recruited 41 patients and 43 healthy exposed controls from five university hospital pneumology departments in France and Switzerland. S. rectivirgula proteins were extracted, separated by 2D electrophoresis, and subjected to Western blotting, with sera from FLD patients or controls. FLD-specific proteins were identified by MS and were produced as recombinant antigens. The diagnostic performance of ELISA tests using the recombinant antigens was assessed with all the sera from FLD patients and controls. We identified 25 FLD-specific proteins, some of which play important roles in transport, nutrition, or virulence. We produced 17 of these proteins as recombinant antigens and assessed their suitability for inclusion in the ELISA test. A combination of three of these proteins (SR1FA, SR17, and SR22) proved remarkably effective at discriminating between patients and controls, with a sensitivity of 83% and a specificity of 77%. The recombinant antigens produced in this study constitute a major step toward the improvement of diagnostic performance and the standardization of FLD serodiagnosis.
ISSN: 1862-8346

hal-01115880
https://hal.archives-ouvertes.fr/hal-01115880
DOI : 10.1002/prca.201400024
PUBMED : 25264606

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : Plant litter diversity effects on decomposition rates are frequently reported, but with a strong bias towards temperate ecosystems. Altered decomposition and nutrient recycling with changing litter diversity may be particularly important in tree species-rich tropical rainforests on nutrient-poor soils. Using 28 different mixtures of leaf litter from 16 Amazonian rainforest tree species, we tested the hypothesis that litter mixture effects on decomposition increase with increasing functional litter diversity. Litter mixtures and all single litter species were exposed in the field for 9 months using custom-made microcosms with soil fauna access. In order to test the hypothesis that the long-term presence of tree species contributing to the litter mixtures increases mixture effects on decomposition, microcosms were installed in a plantation at sites including the respective tree species composition and in a nearby natural forest where these tree species are absent. We found that mixture decomposition deviated from predictions based on single species, with predominantly synergistic effects. Functional litter diversity, defined as either richness, evenness, or divergence based on a wide range of chemical traits, did not explain the observed litter mixture effects. However, synergistic effects in litter mixtures increased with the long-term presence of tree species contributing to these mixtures as the home field advantage hypothesis assumes. Our data suggest that complementarity effects on mixed litter decomposition may emerge through long-term interactions between aboveground and belowground biota.
ISSN: 0029-8549

hal-01032393
https://hal.archives-ouvertes.fr/hal-01032393
DOI : 10.1007/s00442-011-1966-4

Éditeur(s) : HAL CCSD
Résumé : International audience
INTRODUCTION: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is characterized by imaging features consisting of the association of centrilobular and/or paraseptal emphysema and pulmonary fibrosis. Virtually all patients are smokers and thus at high risk of developing lung cancer. METHODS: This retrospective multicentre study was conducted by the Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P). RESULTS: A total of 47 patients presenting with lung cancer and CPFE syndrome were identified. All patients were smokers, with a mean of 47 pack-years. A pathological diagnosis of lung cancer was obtained for 38 (81%) patients. Histological type was squamous cell carcinoma in 17 (36%) patients, adenocarcinoma in 14 (30%), non-small-cell lung cancer not otherwise specified in three (6%), small-cell lung cancer in three (6%), and sarcomatoid carcinoma in one (2%). Overall, 20 of the 47 patients could not receive standard-of-care treatment for lung cancer, as per international recommendations or guidelines; this limitation was considered to be directly related to the CPFE syndrome in eight (40%) cases. CONCLUSION: Lung cancer in patients with CPFE syndrome represents a specific entity with a poor prognosis, that further represents the most characteristic and severe model of tobacco-related disease.
Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer

hal-01063912
https://hal.archives-ouvertes.fr/hal-01063912
DOI : 10.1097/JTO.0000000000000209
PUBMED : 25157769

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Two antifibrotic drugs, pirfenidone and nintedanib, are approved by the European Medicines Agency and the US Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis (IPF). In this analysis, treatment patterns of European patients with IPF were investigated to understand antifibrotic prescribing and identify unmet needs in IPF treatment practice. Methods: Between February and March 2016, respiratory physicians from France, Germany, Italy, Spain, and the UK participated in an online questionnaire designed to collect information on IPF treatment patterns in patients under their care. Patients were categorized as treated (received approved antifibrotics) or untreated (did not receive approved antifibrotics, but may have received other unapproved therapies). Classification of IPF diagnosis (confirmed/suspected) and severity ('mild'/'moderate'/'severe') for each patient was based on the individual physician's report. Patients' perspectives were not recorded in this study. Results: In total, 290 physicians responded to the questionnaire. Overall, 54% of patients with IPF did not receive treatment with an approved antifibrotic. More patients had a confirmed IPF diagnosis in the treated (84%) versus the untreated (51%) population. Of patients with a confirmed diagnosis, 40% did not receive treatment. The treated population was younger than the untreated population (67 vs 70 years, respectively; p = 0.01), with more frequent multidisciplinary team evaluation (83% vs 57%, respectively; p = 0.01). A higher proportion of untreated patients had forced vital capacity > 80% at diagnosis versus treated patients. Of patients with 'mild' IPF, 71% did not receive an approved antifibrotic versus 41% and 60% of patients with 'moderate' and 'severe' IPF, respectively. Conclusions: Despite the availability of antifibrotic therapies, many European patients with confirmed IPF do not receive approved antifibrotic treatment. Importantly, there appears to be a reluctance to treat patients with 'mild' or 'stable' disease, and instead adopt a 'watch and wait' approach. More education is required to address diagnostic uncertainty, poor understanding of IPF and its treatments, and issues of treatment access. There is a need to increase physician awareness of the benefits associated with antifibrotic treatment across the spectrum of IPF severity.
ISSN: 1471-2466

hal-01616061
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616061
DOI : 10.1186/s12890-017-0468-5
PUBMED : 28915874

Éditeur(s) : HAL CCSD
Résumé : International audience
o abstract
Journal of Thoracic Disease

hal-01319894
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01319894
DOI : 10.21037/jtd.2016.03.34
PUBMED : 27162684
PUBMEDCENTRAL : PMC4842784

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Gulf of Cadiz lies astride the complex plate boundary between Africa and Eurasia west of the Betic-Rif mountain belt. We report on the results of recent bathymetric swathmapping and multi-channel seismic surveys carried out here. The seafloor is marked by contrasting morphological provinces, spanning the SW Iberian and NW Moroccan continental margins, abyssal plains and an elongate, arcuate, accretionary wedge. A wide variety of tectonic and gravitational processes appear to have shaped these structures. Active compressional deformation of the wedge is suggested by folding and thrusting of the frontal sedimentary layers as well as basal duplexing in deeper internal units. There is evidence for simultaneous gravitational spreading occurring upslope. The very shallow mean surface and basal slopes of the accretionary wedge (1° each) indicate a very weak decollement layer, geometrically similar to the Mediterranean Ridge accretionary complex. Locally steep slopes (up to 10°) indicate strongly focused, active deformation and potential gravitational instabilities. The unusual surface morphology of the upper accretionary wedge includes “raft-tectonics” type fissures and abundant sub-circular depressions. Dissolution and/or diapiric processes are proposed to be involved in the formation of these depressions.
ISSN: 0264-8172

insu-00401683
https://hal-insu.archives-ouvertes.fr/insu-00401683
DOI : 10.1016/j.marpetgeo.2007.11.008

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
ISSN: 1754-6834

hal-01592860
http://hal.upmc.fr/hal-01592860
http://hal.upmc.fr/hal-01592860/document
http://hal.upmc.fr/hal-01592860/file/s13068-017-0897-7.pdf

Éditeur(s) : HAL CCSD Frontiers
Résumé : International audience
o abstract
ISSN: 1663-4365

hal-01384003
https://hal.archives-ouvertes.fr/hal-01384003
DOI : 10.3389/fnagi.2016.00169
PUBMED : 27462266

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Two of the crucial aspects of human immunodeficiency virus (HIV) infection are (i) viral persistence in reservoirs (precluding viral eradication) and (ii) chronic inflammation (directly associated with all-cause morbidities in antiretroviral therapy (ART)-controlled HIV-infected patients). The objective of the present study was to assess the potential involvement of adipose tissue in these two aspects. Adipose tissue is composed of adipocytes and the stromal vascular fraction (SVF); the latter comprises immune cells such as CD4+ T cells and macrophages (both of which are important target cells for HIV). The inflammatory potential of adipose tissue has been extensively described in the context of obesity. During HIV infection, the inflammatory profile of adipose tissue has been revealed by the occurrence of lipodystrophies (primarily related to ART). Data on the impact of HIV on the SVF (especially in individuals not receiving ART) are scarce. We first analyzed the impact of simian immunodeficiency virus (SIV) infection on abdominal subcutaneous and visceral adipose tissues in SIVmac251 infected macaques and found that both adipocytes and adipose tissue immune cells were affected. The adipocyte density was elevated, and adipose tissue immune cells presented enhanced immune activation and/or inflammatory profiles. We detected cell-associated SIV DNA and RNA in the SVF and in sorted CD4+ T cells and macrophages from adipose tissue. We demonstrated that SVF cells (including CD4+ T cells) are infected in ART-controlled HIV-infected patients. Importantly, the production of HIV RNA was detected by in situ hybridization, and after the in vitro reactivation of sorted CD4+ T cells from adipose tissue. We thus identified adipose tissue as a crucial cofactor in both viral persistence and chronic immune activation/inflammation during HIV infection. These observations open up new therapeutic strategies for limiting the size of the viral reservoir and decreasing low-grade chronic inflammation via the modulation of adipose tissue-related pathways
ISSN: 1553-7366

Droits : http://creativecommons.org/licenses/by/
hal-01207287
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207287
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207287/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207287/file/journal.ppat.1005153.pdf
DOI : 10.1371/journal.ppat.1005153

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The growth of relief in active tectonic areas is mainly controlled by the interactions between tectonics and surface processes (erosion and sedimentation). The study of long-lived morphologic markers formed by these interactions can help in quantifying the competing effects of tectonics, erosion and sedimentation. In regions experiencing active extension, river-long profiles and faceted spurs (triangular facets) can help in un- derstanding the development of mountainous topography along normal fault scarps. In this study, we devel- oped analogue experiments that simulate the morphologic evolution of a mountain range bounded by a normal fault. This paper focuses on the effect of the fault slip rate on the morphologic evolution of the foot- wall by performing three analogue experiments with different fault slip rates under a constant rainfall rate. A morphometric analysis of the modelled catchments allows comparing with a natural case (Tunka half- graben, Siberia). After a certain amount of fault slip, the modelled footwall topographies of our models reaches a dynamic equilibrium (i.e., erosion balances tectonic uplift relative to the base level) close to the fault, whereas the topography farther from the fault is still being dissected due to regressive erosion. We show that the rates of vertical erosion in the area where dynamic equilibrium is reached and the rate of re- gressive erosion are linearly correlated with the fault throw rate. Facet morphology seems to depend on the fault slip rate except for the fastest experiment where faceted spurs are degraded due to mass wasting. A stream-power law is computed for the area wherein rivers reach a topographic equilibrium. We show that the erosional capacity of the system depends on the fault slip rate. Finally, our results demonstrate the pos- sibility of preserving convex river-long profiles on the long-term under steady external (tectonic uplift and rainfall) conditions.
ISSN: 0040-1951

hal-00646966
https://hal.archives-ouvertes.fr/hal-00646966
https://hal.archives-ouvertes.fr/hal-00646966/document
https://hal.archives-ouvertes.fr/hal-00646966/file/preprint_Strak_2011.pdf
DOI : 10.1016/j.tecto.2011.10.005

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The modern high topography of the Tianshan resulted from the reactivation of a Paleozoic orogenic belt by the India/Asia collision. Today, the range exhibits tectonically active forelands and intermontane basins. Based on quantitative morphotectonic observations and age constraints derived from cosmogenic 10Be dating, single-grain post-infrared infrared stimulated luminescence (p-IR IRSL) dating and modeling of fault scarp degradation, we quantify the deformation in the Nalati and Bayanbulak intermontane basins in the central Eastern Tianshan. Our results indicate that at least 1.4 mm/yr of horizontal crustal shortening is accommodated within these two basins. This shortening represents over 15% of the 8.5 ± 0.5 mm/yr total shortening rate across the entire range at this longitude. This shortening rate implies that the Eastern Central Tianshan is thickening at a mean rate of ∼1.4 mm/yr, a rate that is significantly higher than the average denudation rate of 0.14 mm/yr derived from our cosmogenic analysis. This discrepancy suggests that the Tianshan range has not yet reached a steady-state topography and remains in a transient state of topographic growth, most likely due to limited denudation rates driven by the arid climate of Central Asia.
ISSN: 0012-821X

insu-01610154
https://hal-insu.archives-ouvertes.fr/insu-01610154
DOI : 10.1016/j.epsl.2017.09.025

Éditeur(s) : HAL CCSD Elsevier
Résumé :  
Previous studies in lowland tropical rainforests of French Guiana showed that, among non-N2-fixing trees, two groups of late successional species contrasting in their leaf 15N natural abundance coexist, suggesting two different main ways of nitrogen acquisition. Two abundant late-successional species typically co-occurring in rainforests in French Guiana, namely Eperua falcata and Dicorynia guianensis, were chosen as representative of each group. Stable isotope techniques and measurements of potentials of microbial N transformation were performed to assess to what extent leaf 15N natural abundance of these species could be related to (i) d15N signatures of soil mineral N sources and (ii) the capacity of soil to express nitrification and denitrification (both processes being directly involved in the balance between NH4 + and NO3 - ). Soil d15N-NH4 + was roughly similar to leaf d15N of D. guianensis (around 3.5%), suggesting a preferential use of NH4 +, whereas in E. falcata, leaf d15N values were closer to root d15N-NO3 _ values (0.2 and _2.0%, respectively), suggesting a preferential use of NO3 _. These differences in N source utilization were not accompanied by differences in availability in soil NO3 _ or in intensity of microbial functions responsible for soil N mineral evolution. However, (i) under both tree species, these functions showed clear spatial partitioning, with denitrification occurring potentially in soil and nitrification in the litter layer, and (ii) E. falcata fine roots colonized the litter layer much more strongly than D. guianensis fine roots. This strongly suggests that (i) the contrasted leaf d15N values found in the two late-successional species reveal distinct N acquisition strategies and (ii) the ability of roots to predominantly exploit the litter layer (E. falcata) or the soil (D. guianensis) may constitute an important explanation of the observed differences. A complementarity between tree species, based on mineral N resource partitioning (itself resulting from a spatially structured location of the microbial functions responsible for the balance between NH4 + and NO3 - ), can thus be supposed.
ISSN: 0038-0717

hal-01032035
https://hal.archives-ouvertes.fr/hal-01032035
DOI : 10.1016/j.soilbio.2007.09.011

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
Marine micro-and macroorganisms are well known to produce metabolites with high biotechnological potential. Nearly 40 years of systematic prospecting all around the New Caledonia archipelago and several successive research programs have uncovered new chemical leads from benthic and planktonic organisms. After species identification, biological and/or pharmaceutical analyses are performed on marine organisms to assess their bioactivities. A total of 3582 genera, 1107 families and 9372 species have been surveyed and more than 350 novel molecular structures have been identified. Along with their bioactivities that hold promise for therapeutic applications, most of these molecules are also potentially useful for cosmetics and food biotechnology. This review highlights the tremendous marine diversity in New Caledonia, and offers an outline of the vast possibilities for natural products, especially in the interest of pursuing collaborative fundamental research programs and developing local biotechnology programs.
EISSN: 1660-3397

Droits : http://creativecommons.org/licenses/by/
hal-01292225
http://hal.upmc.fr/hal-01292225
http://hal.upmc.fr/hal-01292225/document
http://hal.upmc.fr/hal-01292225/file/marinedrugs-14-00058.pdf
DOI : 10.3390/md14030058

Éditeur(s) : HAL CCSD
Résumé : International audience
Sharks International
Durban, South Africa

hal-01487162
http://hal.univ-reunion.fr/hal-01487162

Éditeur(s) : HAL CCSD
Résumé : International audience
Over the past few years, genetics has significantly improved the understanding of interstitial lung diseases (ILD)...
European Respiratory Journal

hal-01534151
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01534151
DOI : 10.1183/13993003.00407-2017
PUBMED : 28495697

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In French Guiana, severe cases of toxoplasmosis in immunocompetent patients are associated with atypical strains of Toxoplasma gondii linked to a wild neotropical rainforest cycle and a higher genetic diversity than usually observed for T. gondii isolates from anthropized environment. This raises the question of the impact of anthropization of the natural environment, on genetic diversity and on the population structure of T. gondii. However, few data are available on strains circulating in the anthropized areas from French Guiana. Seropositive animals originating mainly from anthropized sub-urban areas and punctually from wild environment in French Guiana were analyzed for T. gondii isolation and genotyping. Thirty-three strains were obtained by bioassay in mice and compared with 18 previously reported isolates chiefly originating from the Amazon rainforest. The genotyping analysis performed with 15 microsatellite markers located on 12 different chromosomes revealed a lower genetic diversity in the anthropized environment. Results were analyzed in terms of population structure by clustering methods, Neighbor-joining trees reconstruction based on genetic distances, F(ST,) Mantel's tests and linkage disequilibrium. They clearly showed a genetic differentiation between strains associated to the anthropized environment and those associated to the wild, but with some inbreeding between them. The majority of strains from the anthropized environment were clustered into additional lineages of T. gondii that are common in the Caribbean. In conclusion the two environmental populations "wild" and "anthropized" were genetically well differentiated. The anthropization of the environment seems to be accompanied with a decreased diversity of T. gondii associated with a greater structure of the populations. We detected potential interpenetration and genetic exchanges between these two environmental populations. As a higher pathogenicity in human of "wild" genotypes has been described, the interpenetration of both environments leads to hybridization between strains that may be at risk for human health.
ISSN: 1567-1348

pasteur-00654105
https://hal-riip.archives-ouvertes.fr/pasteur-00654105
https://hal-riip.archives-ouvertes.fr/pasteur-00654105/document
https://hal-riip.archives-ouvertes.fr/pasteur-00654105/file/Mercier_et_al_IGE2011.pdf
DOI : 10.1016/j.meegid.2011.05.003

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
Type IB DNA topoisomerases can eliminate torsional stresses produced during replication and transcription. These enzymes are found in all eukaryotes and a short version is present in some bacteria and viruses. Among prokaryotes, the long eukaryotic version is only observed in archaea of the phylum Thau-marchaeota. However, the activities and the roles of these topoisomerases have remained an open question. Here, we demonstrate that all available thaumar-chaeal genomes contain a topoisomerase IB gene that defines a monophyletic group closely related to the eukaryotic enzymes. We show that the topIB gene is expressed in the model thaumarchaeon Ni-trososphaera viennensis and we purified the recom-binant enzyme from the uncultivated thaumarchaeon Candidatus Caldiarchaeum subterraneum. This enzyme is active in vitro at high temperature, making it the first thermophilic topoisomerase IB characterized so far. We have compared this archaeal type IB enzyme to its human mitochondrial and nuclear counterparts. The archaeal enzyme relaxes both negatively and positively supercoiled DNA like the eukaryotic enzymes. However, its pattern of DNA cleavage specificity is different and it is resistant to camptothecins (CPTs) and non-CPT Top1 inhibitors, LMP744 and lamellarin D. This newly described ther-mostable topoisomerases IB should be a promising new model for evolutionary, mechanistic and structural studies.
ISSN: 0305-1048

Droits : http://creativecommons.org/licenses/by/
hal-01327354
http://hal.upmc.fr/hal-01327354
http://hal.upmc.fr/hal-01327354/document
http://hal.upmc.fr/hal-01327354/file/Nucl.%20Acids%20Res.-2016-Dahmane-2795-805.pdf
DOI : 10.1093/nar/gkw097

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc=0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc=0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.
ISSN: 0198-8859

inserm-00864639
http://www.hal.inserm.fr/inserm-00864639
http://www.hal.inserm.fr/inserm-00864639/document
http://www.hal.inserm.fr/inserm-00864639/file/HLA-G_and_BD_manuscript_-1.pdf
DOI : 10.1016/j.humimm.2012.11.032

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
While the effects of deforestation and habitat fragmentation on parasite prevalence or richness are well investigated, host-parasite networks are still understudied despite their importance in understanding the mechanisms of these major disturbances. Because fragmentation may negatively impact species occupancy, abundance and co-occurrence, we predict a link between spatiotemporal changes in habitat and the architecture of host-parasite networks. For this, we used an extensive data set on 16 rodent species and 29 helminth species from seven localities of South-East Asia. We analysed the effects of rapid deforestation on connectance and modularity of helminth-parasite networks. We estimated both the degree of fragmentation and the rate of deforestation through the development of land uses and their changes through the last 20 to 30years in order to take into account the dynamics of habitat fragmentation in our statistical analyses. We found that rapid fragmentation does not affect helminth species richness per se but impacts host-parasite interactions as the rodent-helminth network becomes less connected and more modular. Our results suggest that parasite sharing among host species may become more difficult to maintain with the increase of habitat disturbance.
ISSN: 0021-8790

hal-01355307
https://hal.archives-ouvertes.fr/hal-01355307
DOI : 10.1111/1365-2656.12368
IRD : fdi:010064927

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Iron is an essential micronutrient involved in many biological processes and is often limiting for primary production in large regions of the World Ocean. Metagenomic and physiological studies have identified clades or ecotypes of marine phytoplankton that are specialized in iron depleted ecological niches. Although less studied, eukaryotic picophytoplankton does contribute significantly to primary production and carbon transfer to higher trophic levels. In particular, metagenomic studies of the green picoalga Ostreococcus have revealed the occurrence of two main clades distributed along coast-offshore gradients, suggesting niche partitioning in different nutrient regimes. Here, we present a study of the response to iron limitation of four Ostreococcus strains isolated from contrasted environments. Whereas the strains isolated in nutrient-rich waters showed high iron requirements, the oceanic strains could cope with lower iron concentrations. The RCC802 strain, in particular, was able to maintain high growth rate at low iron levels. Together physiological and transcriptomic data indicate that the competitiveness of RCC802 under iron limitation is related to a lowering of iron needs though a reduction of the photosynthetic machinery and of protein content, rather than to cell size reduction. Our results overall suggest that iron is one of the factors driving the differentiation of physiologically specialized Ostreococcus strains in the ocean.
ISSN: 2045-2322

Droits : http://creativecommons.org/licenses/by/
hal-01502140
http://hal.upmc.fr/hal-01502140
http://hal.upmc.fr/hal-01502140/document
http://hal.upmc.fr/hal-01502140/file/acclimation.pdf
DOI : 10.1038/s41598-017-00216-6