Éditeur(s) : HAL CCSD Société géologique de France
Résumé : International audience
The Messinian salinity crisis (MSC) is characterized by gigantic erosion that remodels the margins while a thick, essentially evaporitic and detrital, sedimentary sequence forms in the deep basins. Based on recent (MAURESC, 2003) and earlier (MESEA 1, 1990; MAGIRAA, 1996; GEOBREST, 2002) seismic reflection data, this work brings to light the record of the MSC on the Provençal margin, which has until now been rarely explored from this perspective. Beyond its strictly regional interest, this study fits into a larger synthesis of MSC seismic markers in the Mediterranean and Black Sea marine domain [Lofi et al., 2011] and employs the new nomenclature established on this occasion. The results obtained reveal a Messinian detrital body (CU unit) of 625 metres maximum thickness at the foot of the margin, accumulating at the mouths of the principal canyons. Its form, facies and extension assimilate it to clastic fans, fed by subaerial erosion linked to the MSC. The relative geometry of CU and the Messinian units MU and UU deposited in the deep basin give indications to their chronostratigraphic relations. The deposition of the CU unit is posterior to the basal part of the mobile unit consisting of halite (MU), but contemporary to its top. These results agree with the recent scenarii, which propose that the precipitation of MU in the basin began early, during the lowering of the sea level, and ended at a low level during the MSC [Blanc, 2000; Martin et al., 2001; Sage et al., 2005; Ryan, 2009]. The UU unit surmounts MU and is subdivided into two sub-units with perceptibly different seismic facies : UU1 at the base and UU2 at the summit. UU1 could correspond to a unit containing more halite and/or more clastic material than UU2. The UU1 sub-unit could be partially contemporary to the CU unit. Concerning salt tectonics and its markers, three structural provinces have been evidenced in the sector of study, respectively : an upslope domain in extension (normal faults), an intermediary domain in translation (tabular MU) and a downslope domain in contraction (salt diapirs). These domains are directly linked to the gravity spreading and/or gliding of the brittle sedimentary cover formed by the CU, UU and Plio-Quatenary units and of the mobile level, MU. In the study area, a close relation between the distribution and thickness of CU and salt tectonics has additionally been evidenced at the mouths of the large Messinian canyons, being best expressed where CU is thick.
EISSN: 1777-5817

hal-00498286
https://hal.archives-ouvertes.fr/hal-00498286

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
S U M M A R Y Over the last decade, thermomechanical models have revealed the control of both tectonics and erosion on the morphology of continental plateaus margins. However, unravelling the specific effects of these two coupled processes has been difficult in practice. Here, to assess the control of erosion, we investigate the dynamics of the eastern and the northern borders of the Tibetan Plateau, which are characterized by a low convergence rate and a steep topographic escarpment adjacent to the Sichuan and Tarim basins, respectively. Thermomechanical modelling of continental lithosphere coupled with fluvial denudation reveals that important crustal deformation with large-scale horizontal displacements can occur, without any convergence, as a response to mass transfer due to gravitational collapse and to erosional unloading. These processes are sensitive to crustal structure, geothermal gradient as well as surface erosion. At a timescale of several million years, our results suggest that this denudation-triggered deformation exerts a primary control on the evolution of those plateau margins by counterbalancing the mass removal due to erosion and stabilizing the topographic escarpment. This finding supports a possible explanation for the morphology of the Longmen Shan, eastern Tibet, in which the paradoxical combination of persistent high-topographic gradients close to the foreland and low convergence rates can be related to the influence of erosion on deformation patterns.
ISSN: 0956-540X

hal-01577060
https://hal-amu.archives-ouvertes.fr/hal-01577060
https://hal-amu.archives-ouvertes.fr/hal-01577060/document
https://hal-amu.archives-ouvertes.fr/hal-01577060/file/godard2009erosional.pdf
DOI : 10.1111/j.1365-246X.2009.04324.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Second harmonic generation (SHG) microscopy is a powerful tool for studying submicron architecture of muscles tissues. Using this technique, we show that the canonical single frequency sarcomeric SHG intensity pattern (SHG-IP) of premetamorphic xenopus tadpole tail muscles is converted to double frequency (2f) sarcomeric SHG-IP in metamorphic climax stages due to massive physiological muscle proteolysis. This conversion was found to rise from 7% in premetamorphic muscles to about 97% in fragmented muscular apoptotic bodies. Moreover a 66% conversion was also found in non-fragmented metamorphic tail muscles. Also, a strong correlation between predominant 2f sarcomeric SHG-IPs and myofibrillar misalignment is established with electron microscopy. Experimental and theoretical results demonstrate the higher sensitivity and the supra resolution power of SHG microscopy over TPEF to reveal 3D myofibrillar misalignment. From this study, we suggest that 2f sarcomeric SHG-IP could be used as signature of triad defect and disruption of excitation–contraction coupling. As the mechanism of muscle proteolysis is similar to that found in mdx mouse muscles, we further suggest that xenopus tadpole tail resorption at climax stages could be used as an alternative or complementary model of Duchene muscular dystrophy.
ISSN: 1047-8477

hal-01134174
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134174
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134174/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134174/file/Recher%20et%20al_JSB-2015_hal.pdf
DOI : 10.1016/j.jsb.2015.03.003

Éditeur(s) : Springer
Résumé : The compilation of results obtained on three giant piston cores from the Whittard, Shamrock and Guilcher turbidite levees reveals a high-resolution stratigraphic record for the Bay of Biscay. Due to the abundance of reworked sediments in these sedimentary environments, a specific methodological approach, based on an X-ray-assisted subsampling phase associated with sedimentological, geochemical and micropalaeontological analyses, was implemented. With an accurate chronological framework, this multi-proxy investigation provides observations on the 'Fleuve Manche' palaeoriver and the British-Irish Ice Sheet (BIS) histories over the last 20,000 years. The results obtained highlight the direct influence of the decay of the BIS on the Bay of Biscay deep-sea clastic sedimentation during the last European deglacial phase. During this period, the annual BIS cycle of meltwater seems enough to generate seasonal turbidity currents associated with exceptional sedimentation rates in all the Celtic and Armorican turbidite systems. With very high sedimentation rates, the turbidite levees represent the main deep-sea clastic depositional area. Long coring combined with a very careful subsampling method can provide continuous high-resolution palaeoenvironmental signals.
Geo-Marine Letters (0276-0460) (Springer), 2006-12 , Vol. 26 , N. 6 , P. 317-329

Droits : 2006 Springer Science+Business Media
http://archimer.ifremer.fr/doc/2006/publication-2142.pdf
DOI:10.1007/s00367-006-0048-9
http://archimer.ifremer.fr/doc/00000/2142/

Éditeur(s) : HAL CCSD
Résumé : The territory of Armenia was located in the collision zone between Arabia and Eurasia, and is the seat of active intercontinental deformations, which was attested by the many historical earthquakes that have occurred in this region. All these destructive earthquakes show a strong regional seismic activity, and therefore it is important to evaluate the seismic hazard associated with active structures that generates this seismicity.This study presents the results of the analysis of the active tectonics within the northwestern and southeastern extensions of the Pambak-Sevan-Syunik fault (PSSF), a major right-lateral strike-slip fault cutting through Armenia (NW - SE). Quantifying the deformations in terms of geometry, kinematics, slip rates and earthquake activity, using cosmogenic 3He, OSL/IRSL and radiocarbon dating techniques, reveal different behaviors between the two regions.Within the northwestern extension, in the region of Amassia, the PSSF bends to the west and splits into two main WNW-ESE trending reverse faults defining a compressional pop-up structure. We estimate an uplift rate and a shortening rate of 0.5 ± 0.1 mm/y and 1.4 ± 0.6 mm/y, respectively. This suggests that most of the ~2 mm/y right lateral movement of the PSSF seems to be absorbed within the Amasia pop-structure.Within the southeastern extension, in the region of Tsghuk volcano, the PSSF shows signs of dying out at the southernmost tip of the Syunik graben. A very slow NS trending normal faulting associated with a slight right-lateral movement characterizes the tectonic activity in the region of Tsghuk volcano. We estimate vertical slip rates, EW stretching rate, and right-lateral slip rate of ~0.2 mm/y, ~0.1 mm/y and ~0.05 mm/y, respectively. These results lead to the conclusion that the right lateral movement observed further north along the PSSF is mainly transferred within other active faults further west within the Karabagh (Hagari fault or other structures further northwestwards).
L’Arménie se situe dans la zone de collision entre Arabie et Eurasie et est le siège d’une déformation intracontinental active comme l’atteste les nombreux tremblements de terre historiques qui s’y sont produits. Tous ces séismes, destructeurs, attestent d’une forte activité sismique régionale, et il est par conséquent important d'évaluer l’aléa sismique associé aux structures actives qui génère cette sismicité.Le travail présenté ici, expose les résultats de l’analyse de la tectonique active au niveau des terminaisons nord-ouest et sud-est de la faille de Pambak-Sevan-Syunik (PSSF), une des failles décrochant majeure qui traverse l'Arménie du NW au SE. La quantification des déformations en termes de géométrie, cinématique, vitesse de glissement et paléosismicité, en utilisant les méthodes de datation 3He cosmogénique, OSL/IRSL et radiocarbone, révèlent des comportements différents entre les deux régions.Au niveau de la terminaison nord-ouest, dans la région d’Amassia, la faille PSSF s’incurve vers l'ouest et se subdivise en deux branches de direction WNW-ESE, et de cinématique inverse, définissant une structure en pop-up. Nous estimons une vitesse de soulèvement de 0.5 ± 0.1 mm/an et une vitesse de raccourcissement NNE-SSW de 1.4 ± 0.6 mm/an. Ces résultats suggère que l’essentiel des ~2 mm/an de mouvement dextre estimés le long de la faille de PSSF sont absorbés au niveau du pop-up d’Amassia.Au niveau de la terminaison sud-est, dans la région du volcan Tsghuk, la faille PSSF semble disparaitre. Le peu d’activité tectonique est caractérisée par des failles normales sub-méridiennes associées à une légère composante décrochant dextre. Nous déterminons une vitesse de glissement vertical de ~0,2 mm/an, une vitesse d’extension ~EW de ~0,1 mm/an associée à une composante dextre de ~0,05 mm/an. Ces résultats suggèrent que le mouvement dextre observé le long de la faille de PSSF plus au nord, a été transféré sur d'autres failles plus à l'ouest dans le Karabakh (faille Hagari ou autres structures situés encore plus au NW).
https://tel.archives-ouvertes.fr/tel-01621440

NNT : 2016MONTT152
tel-01621440
https://tel.archives-ouvertes.fr/tel-01621440
https://tel.archives-ouvertes.fr/tel-01621440v2/document
https://tel.archives-ouvertes.fr/tel-01621440/file/2016_MKRTCHYAN_archivage.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
A prospective study on randomized patients was conducted to determine how morphokinetic parameters are altered in embryos grown in sequential versus global culture media. Eleven morphokinetic parameters of 160 single embryos transferred were analyzed by time lapse imaging involving two University-affiliated in vitro fertilization (IVF) centers. We found that the fading of the two pronuclei occurred earlier in global (22.56±2.15 hpi) versus sequential media (23.63±2.71 hpi; p=0.0297). Likewise, the first cleavage started earlier at 24.52±2.33 hpi vs 25.76±2.95 hpi (p=0.0158). Also, the first cytokinesis was shorter in global medium, lasting 18±10.2 minutes in global versus 36±37.8 minutes in sequential culture medium (p <0.0001). We also observed a significant shortening in the duration of the 2-cell stage in sequential medium: 10.64 h±2.75 versus 11.66 h±1.11 in global medium (p=0.0225) which suggested a faster progression of the embryos through their first mitotic cell cycle. In conclusion, morphokinetic analysis of human embryos by Time lapse imaging reveals significant differences in five kinetic variables according to culture medium. Our study highlights the need to adapt morphokinetic analysis accordingly to the type of media used to best support human early embryo development.
Annales de Biologie Clinique

hal-01579406
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579406
DOI : 10.1684/abc.2017.1259
PUBMED : 28751285

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : L’incendie de forêt reste incontestablement un des facteurs de dégradation les plus dévastateurs dans le bassin méditerranéen, lequel est caractérisé par une végétation très inflammable et des conditions climatiques chaudes et sèches. Le Maroc, pays du pourtour méditerranéen, n’est pas épargné par ce fléau, avec 3000 ha de forêts qui partent annuellement en fumée ; cette situation est aggravée par les difficultés de régénération et de restauration des espaces, marqués par une vulnérabilité naturelle telle que celle de la Mâamora. Pour répondre à cela, la conception d’un plan d’aménagement anti-feux visant à conférer à la forêt de la Mâamora une immunité élevée contre les incendies, nécessite non seulement une connaissance approfondie du milieu, mais aussi une analyse appropriée du phénomène « incendie ». La présente étude qui se penche sur le diagnostic et l’analyse des incendies survenus en Mâamora, a permis de constater que les zones d’interface homme-forêt (routes, douars, etc.) n’ont pas d’influence sur l’occurrence des incendies. Il ressort également que l’activité pastorale, pratiquée d’une certaine façon, pourrait jouer un rôle important dans la diminution des risques d’incendie. En outre l’étude révèle que la charge du combustible représente le facteur prépondérant qui régit à la fois l’éclosion des incendies et leur propagation, cette charge étant étroitement liée à la qualité de la station (sol et pluviométrie).
Forest fires are the main disturbance and the degradation factor most devastating that can affect forested areas, especially in the Mediterranean basin when species are highly flammable and climate conditions are marginal. Morocco as a Mediterranean country is not spared from this phenomenon, thus 3000 ha of forest are burned every year, and this situation is aggravated by the low rate of regeneration and restoration of the unbalanced ecosystems such as the Mâamora. To mitigate this situation, the establishment of an effective management plan for forest fire prevention requires not only an intimate knowledge of environment but also a perfect analysis of fire phenomenon. Therefore in this study, we focused our diagnosis on the analysis of old fires occurred in the past in Mâamora forest. The study highlighted that human-forest interface areas (roads, villages) have no influence on fires occurrence. Besides it was shown that grazing practiced in a well-balanced way, could play a key role in reducing fire hazards. In addition the study reveals that fuel load of is the major factor that governs both fire ignition and fire spread of, this load is closely related to site quality (soil and rainfall)
Maroc

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.10978
http://journals.openedition.org/etudescaribeennes/10978

Éditeur(s) : HAL CCSD Elsevier
Résumé : This manuscript is an extended version, including an updated bibliography, of the article: Hierarchical cooperativity mediated by chromatin remodeling; the model of the MMTV transcription regulation. Michel, D. 2011. J. Theor. Biol. 287, 74-81
International audience
Chromatin remodeling machineries are abundant and diverse in eukaryotic cells. They have been involved in a variety of situations such as histone exchange and DNA repair, but their importance in gene expression remains unclear. Although the influence of nucleosome position on the regulation of gene expression is generally envisioned under the quasi-equilibrium perspective, it is proposed that given the ATP-dependence of chro-matin remodeling enzymes, certain mechanisms necessitate non-equilibrium treatments. Examination of the celebrated chromatin remodeling system of the mouse mammary tumor virus, in which the binding of transcription factors opens the way to other ones, reveals that breaking equilibrium offers a subtle mode of transcription factor cooperativity, avoids molecular trapping phenomena and allows to reconcile previously conflicting experimental data. This mechanism provides a control lever of promoter responsiveness to transcription factor combinations, challenging the classical view of the unilateral influence of pioneer on secondary transcription factors.
ISSN: 0022-5193

hal-01211233
https://hal.archives-ouvertes.fr/hal-01211233
https://hal.archives-ouvertes.fr/hal-01211233/document
https://hal.archives-ouvertes.fr/hal-01211233/file/nucleosome.pdf
ARXIV : 1509.07440

Éditeur(s) : HAL CCSD Springer
Résumé : International audience
Playbacks are a useful tool for conducting well-controlled and replicated experiments on the effects of anthropogenic noise, particularly for repeated exposures. However, playbacks are unlikely to fully reproduce original sources of anthropogenic noise. Here we examined the sound pressure and particle acceleration of boat noise playbacks in a field experiment and reveal that although there remain recognized limitations, the signal-to-noise ratios of boat playbacks to ambient noise do not exceed those of a real boat. The experimental setup tested is therefore of value for use in experiments on the effects of repeated exposure of aquatic animals to boat noise.
The Effects of Noise on Aquatic Life II

ISBN : 978-1-4939-2980-1 (Print) 978-1-4939-2981-8 (Online)
hal-01270660
https://hal-univ-perp.archives-ouvertes.fr/hal-01270660
DOI : 10.1007/978-1-4939-2981-8_55

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
The 1415 m deep IODP Hole U1309D (Mid-Atlantic Ridge, 30 degrees N) is the second deepest hole drilled into slow spreading oceanic lithosphere. The recovered section comprises essentially gabbroic rocks, with a large range of compositions. The most primitive end-members of the gabbroic sequence, herein referred to as olivine-rich troctolites (ol > similar to 70%), have textures and geochemical compositions intermediate between that of mantle peridotites and primitive cumulates, indicative of melt impregnation processes. We carried out a detailed microstructural study to further characterize the petrogenetic processes leading to their formation, as well as discuss their mode of emplacement and relationship with neighboring mantle lithosphere. In olivine-rich troctolites, olivines range from coarse-grained subhedral crystals, commonly containing well-developed subgrains, to medium-grained rounded crystals with fewer or no substructures. They are embedded in large, undeformed pyroxene and plagioclase poikiloblasts. Olivine substructures reveal dislocation creep that is consistent with activation of the main high-temperature slip systems, dominantly (010)[100]. Olivine crystallographic preferred orientation is very weak but generally shows a relatively stronger, uncommon [001] concentration. These unusual olivine fabrics are interpreted as resulting from melt impregnation of a previously deformed olivine matrix: the solid olivine framework is disrupted by olivine corrosion along grain and subgrain boundaries, and the high-temperature plastic fabric is modified in a liquid-dominated regime. Based on mineral composition and fabrics and in comparison with what is observed in impregnated mantle rocks elsewhere, we posit that olivine represents relicts of mantle peridotites disaggregated by large melt influx, although the mantle origin of olivine is not unequivocally demonstrated yet. Whatever the initial lithology, impregnation by large volumes of melt has strongly modified the original composition and microstructure. If the mantle origin hypothesis is correct, the original olivine fabric could have been efficiently weakened by dunitization prior to disruption of the olivine framework by melt impregnation. Incorporation, at the base of the lithosphere, of small slivers of impregnated dunite into gabbroic sections, trapped between successive igneous units, may be a common mechanism of lower crustal accretion at slow spreading ridges. Extensive melt-rock interaction processes are expected to contribute significantly to the final chemical composition of erupted lavas.
ISSN: 1525-2027

hal-00496391
https://hal.archives-ouvertes.fr/hal-00496391
DOI : 10.1029/2009GC002995

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : A study combining very high resolution seismic and sediment core data has been carried out on the Thau lagoon (Mediterranean coast, microtidal setting, SE France) in order to understand more clearly the dynamics and Holocene chronology of its closure through the different stages of its filling. One main seismic unit (U2) has been defined into the infill, above the rocky basement (U0) and a composite unit U1, which is interpreted as remnants of Pleistocene fluvial terraces or/and to early marine Holocene deposits. Unit U2, that reaches locally 9 m in thickness, rests conformably on U1 in the central part of the lagoon and onlaps U0 or U1 close to the edge of the lagoon. It is divided in two sub-units, U2-1 and U2-2. U2-2 rests paraconformably on U2-1 in the central part of the lagoon where the infill is the thickest, while a marked erosional unconformity is observed between U2-1 and U2-2 on topographic highs of the basement and on the seaward edge of the lagoon. A total of seven elementary sequences have been observed in U2-1 and U2-2.;According to core data, U2 consists in a series of mud-dominated sequences, with shell fragments dispersed at the base. The vertical distribution of the fauna into U2-1 and U2-2 reveals a lagoonal environment. However in U2-1, marine species are more abundant in the south of the lagoon. C-14 AMS dating provides three ages: similar to 6000 cal yr B.P. in the lower part of U2-1 on CAL1, 5400 cal yr B.P. just above the boundary between U2-1 and U2-2 on CAL4, similar to 3000 cal yr B.P. in the middle of U2-2 on CAL4.;A scenario to explain the lagoon infill stratigraphy and geometry is proposed. The beginning of the lagoon infill occurred with the initiation of the barrier construction, as soon as the sea-level rise slowed down significantly, i.e. between 7000-6000 yr B.P. The sediment-fill began into the back-barrier system, with a high rate of sedimentation for U2-1, according to the radiocarbon data. At 5400 yr B.P., the barrier is assumed to be totally closed leading to the deposition of the fully lagoonal U2-2 succession. The unconformity between U2-1 and U2-2 is interpreted as the result of a rapid landward retreat of the barrier. This severe retreat could be related to climate forcing and/or brutal change in sediment discharge driven by the Rhone River, which is the main sediment source of the longshore drift. In this scenario, the last sub-unit, U2-2, represents most of the late Holocene infill. In this framework, the elementary sequences observed in U2-2 could be related to high frequency climate changes of about 1000-1500 years periodicity according to C-14 dates.
EISSN: 1777-5817

hal-00486386
https://hal.archives-ouvertes.fr/hal-00486386
DOI : 10.2113/gssgfbull.181.2.197

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Miradouro da Lua cliffs, which are 60 km south of Luanda, record the building and uplift of the late Neogene Palaeo-Cuanza delta. The detailed study of the sedimentary architecture and stacking pattern permitted separation of the pile into five depositional units bounded by erosional surfaces and characterised by separate facies associations (genetic sequences = units in this paper). At the base of the series, aeolian deposits (Unit 1) mark the development of a possible coastal desert during the late Miocene aridification. The major Pliocene sea-level rise (Transgressive Systems Tract) led to the drowning of the continental platform into a discrete shoreface-foreshore sequence (Unit 2), followed by an expanded deltaic sequence (Unit 3) that represents the main outcrop of the area. The sedimentary fabric of this prograding wedge during the Highstand Systems Tract reveals laterally stacked pluri-hectometic mouth bars built by the abrupt switching of a bird-foot delta during the Pliocene highstand. The clinoforms are deeply incised by submarine gullies filled both by periodic river-driven turbidite and tidal currents (Unit 4) during the coeval growing of the delta. The topset of the prograding wedge and associated gullies infill is truncated by an overall erosional unconformity that marks the widespread development of an extensive braid-delta system (Unit 5) during the lower Pleistocene sea-level drop (Lowstand Systems Tract). The last 6 m of the Braid-delta unit is overprinted by a ferallitic profile, forming the surface of the plateau and indicating long-term subaerial exposure and weathering processes consistent with the maximum warming of the middle to late Pleistocene interglacial periods. The successive abrupt shifts of the depositional systems through the sedimentary pile indicate a high-amplitude sea level amplified by major coastal uplifts and the reorganisation of the fluvial network. In this context, the palaeo-Cuanza prograding wedge signals the westward tilting and 60 m total uplift of the coastal plain during the Pliocene. A new uplift pulse by differential tilt and slope increase is deduced from the widespread development of the braid-delta complex during the early Pleistocene. The last tectonic event corresponds to the 80- to 100-m uplift and ferallitic paedogenesis during the middle to late Pleistocene interglacial stages.
ISSN: 0899-5362

hal-01053716
https://hal.archives-ouvertes.fr/hal-01053716
DOI : 10.1016/j.jafrearsci.2014.01.013

Éditeur(s) : HAL CCSD Mineralogical Society of America
Résumé : International audience
Wadsleyites with various iron contents were synthesized at ~12-14 GPa and 1400 °C under oxidizing and hydrous conditions in coexistence with enstatite. The samples were studied using micro-X-ray absorption near edge structure (XANES) and micro-Mössbauer spectroscopy to determine the ferric iron contents in polyphasic samples and secondary ion mass spectrometry (SIMS) to determine the water concentrations. XANES and Mössbauer analyses show that ferric iron content increases with increasing total iron content, and reaches a maximum of ~30% Fe3+/Fetotal. Two XANES results were cross-checked by Mössbauer analysis and both methods are in reasonable agreement. The use of Fourier transform infrared spectroscopy reveals a new protonation scheme in wadsleyite, with a significant proportion of protons associated with the high-frequency band at 3611 cm−1 and a new band located at 3500 cm−1. The intensity of these two bands is higher for Fe3+-rich wadsleyite. SIMS analyses show that water contents in wadsleyite vary from 4500 to 9400 ppm H2O by weight. Pyroxene water contents range from 790 to 1600 ppm wt H2O. The concentration of water in both phases decreases with increasing iron content. The partition coefficient of water between wadsleyite and pyroxene varies between 5 and 9 and increases with increasing Fe-number of wadsleyite [i.e., XFe/(XFe + XMg) × 100 ratio]. The divalent cation concentrations (i.e., Mg2+ + Fe2+), the Si as well as the H content in wadsleyite decrease with increasing Fe3+ content, indicating an incorporation mechanism via substitution into the metal (Me = Mg2+ and Fe2+) and Si sites with a ratio of 5/3 for (Fe3++H+):Me and of 5/1 for (Fe3++H+):Si, similarly as in the dry system. Thus, coupled substitution of Fe3+ and H+ does not affect the incorporation mechanism of Fe3+, but does affect the location of H+, which is partly incorporated at tetrahedral edges forming [FeSi′-(OH)o*]X neutral defects substituting for Si. In this model 25% of the ferric iron occupies the tetrahedral sites.
ISSN: 0003-004X

hal-00758071
https://hal.archives-ouvertes.fr/hal-00758071
DOI : 10.2138/am.2012.3869

Éditeur(s) : HAL CCSD
Résumé : International audience
The hierarchical architecture of biopolymers induces remarkable behaviour. Wood mechanical properties mainly originate from the organization of wood tissue and interactions of cellwall components. The respective contribution on components inside those networks occurs at nanometric scale and still challenging to investigate in-situ. X-ray scattering techniques are now used as a routine technique to investigate internal organization of material components. For that purpose large-scale synchrotron facilities like ESRF offer leading X-ray sources capabilities (large energy range, high brilliance, high intensity, dedicated setups). ESRF's ID13 beamline serves high spacial resolution scanning setups to expertise in elastic scattering of monochromatic X-rays. Since analytical description of the scattering signal of cellulose have been well describe wood material benefit wide range of exposure conditions and sample environment. During this conference, we will present our achievements based on transverse sections of poplar specimens exposed to micrometric beam (1.2 μm side, 12.6 keV energy) to reveal crystalline cellulose distribution within wood tissue and to nanometric beam (100 nm side, 12 6 keV energy) to map the evolution of cellulose orientation within double cell wall over combined Wide-Angle (WAXS) and Small-Angle (SAXS) X-ray Scattering configuration. Within those setups hygrometric sample environment and stretching solicitations will be approached based on-going developments.
COST FP0802 Workshop 'Micro Characterisation of Wood Material'
Edimbourg, United Kingdom

hal-01113298
https://hal.archives-ouvertes.fr/hal-01113298

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
Enhancers are developmentally controlled transcriptional regulatory regions whose activities are modulated through histone modifications or histone variant deposition. In this study, we show by genome-wide mapping that the newly discovered deoxyribonucleic acid (DNA) modification 5-hydroxymethylcytosine (5hmC) is dynamically associated with transcription factor binding to distal regulatory sites during neural differentiation of mouse P19 cells and during adipocyte differentiation of mouse 3T3-L1 cells. Functional annotation reveals that regions gaining 5hmC are associated with genes expressed either in neural tissues when P19 cells undergo neural differentiation or in adipose tissue when 3T3-L1 cells undergo adipocyte differentiation. Furthermore, distal regions gaining 5hmC together with H3K4me2 and H3K27ac in P19 cells behave as differentiation-dependent transcriptional enhancers. Identified regions are enriched in motifs for transcription factors regulating specific cell fates such as Meis1 in P19 cells and PPARγ in 3T3-L1 cells. Accordingly, a fraction of hydroxymethylated Meis1 sites were associated with a dynamic engagement of the 5-methylcytosine hydroxylase Tet1. In addition, kinetic studies of cytosine hydroxymethylation of selected enhancers indicated that DNA hydroxymethylation is an early event of enhancer activation. Hence, acquisition of 5hmC in cell-specific distal regulatory regions may represent a major event of enhancer progression toward an active state and participate in selective activation of tissue-specific genes.
ISSN: 0305-1048

inserm-00716879
http://www.hal.inserm.fr/inserm-00716879
http://www.hal.inserm.fr/inserm-00716879/document
http://www.hal.inserm.fr/inserm-00716879/file/nar.gks595.full.pdf
DOI : 10.1093/nar/gks595

Éditeur(s) : HAL CCSD Geological Society of London
Résumé : International audience
Low-velocity zones ('bright spots') imaged by the INDEPTH seismic experiment in southern Tibet are extensively interpreted as widespread partial melt within the crust, which has given a strong support for the channel flow model. These suggest that a continuous seismic low-velocity zone underlies Tibet on the large scale. Here we take advantage of the Hi-CLIMB seismic experiment which includes a dense south-north profile and a lateral 2D seismic network to assess the vertical and the horizontal extension of low-velocity zones in southern Tibet. Several approaches including migration, amplitude analysis and waveform inversion of receiver functions are performed to detect crustal low-velocity zones using this new seismological dataset. Our results reveal localized and discontinuous low-velocity zones in Tibet. They indicate that the vertical extension of the low-velocity zones is about 10 km, and their maximum horizontal length appears to be c. 50 km. Our study suggests a partial correlation between the location of these low-velocity zones and the spatial distribution of Tibetan grabens. These results, especially the non-continuity of low-velocity zones, together with the observed regular value of mean crustal VP/VS ratio, question the existence of widespread partial melt of the southern Tibetan crust and, therefore, the viability of the channel flow model.
Growth and Collapse of the Tibetan Plateau

hal-00853971
https://hal.archives-ouvertes.fr/hal-00853971
DOI : 10.1144/SP353.6

Éditeur(s) : HAL CCSD Frontiers Media
Résumé : The disease, Heartwater, caused by the Anaplasmataceae E. ruminantium, represents a major problem for tropical livestock and wild ruminants. Up to now, no effective vaccine has been available due to a limited cross protection of vaccinal strains on field strains and a high genetic diversity of Ehrlichia ruminantium within geographical locations. To address this issue, we inferred the genetic diversity and population structure of 194 E. ruminantium isolates circulating worldwide using Multilocus Sequence Typing based on lipA, lipB, secY, sodB, and sucA genes. Phylogenetic trees and networks were generated using BEAST and SplitsTree, respectively, and recombination between the different genetic groups was tested using the PHI test for recombination. Our study reveals the repeated occurrence of recombination between E. ruminantium strains, suggesting that it may occur frequently in the genome and has likely played an important role in the maintenance of genetic diversity and the evolution of E. ruminantium. Despite the unclear phylogeny and phylogeography, E. ruminantium isolates are clustered into two main groups: Group 1 (West Africa) and a Group 2 (worldwide) which is represented by West, East, and Southern Africa, Indian Ocean, and Caribbean strains. Some sequence types are common between West Africa and Caribbean and between Southern Africa and Indian Ocean strains. These common sequence types highlight two main introduction events due to the movement of cattle: from West Africa to Caribbean and from Southern Africa to the Indian Ocean islands. Due to the long branch lengths between Group 1 and Group 2, and the propensity for recombination between these groups, it seems that the West African clusters of Subgroup 2 arrived there more recently than the original divergence of the two groups, possibly with the original waves of domesticated ruminants that spread across the African continent several thousand years ago.
ISSN: 2235-2988

hal-01594501
https://hal.archives-ouvertes.fr/hal-01594501
https://hal.archives-ouvertes.fr/hal-01594501/document
https://hal.archives-ouvertes.fr/hal-01594501/file/paper_MLST_ER_2016_%7B51027B58-C2C7-41C8-9746-BD8A9F387C87%7D.pdf
DOI : 10.3389/fcimb.2016.00111

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
No major earthquake occurred in North Chile since the 1877 Mw 8.6 subduction earthquake that produced a huge tsunami. However, geodetic measurements conducted over the last decade in this area show that the upper plate is actually deforming, which reveals some degree of locking on the subduction interface. This accumulation of elastic deformation is likely to be released in a future earthquake. Because of the long elapsed time since 1877 and the rapid accumulation of deformation (thought to be 6-7 cm yr−1), many consider this area is a mature seismic gap where a major earthquake is due and seismic hazard is high. We present a new Global Positioning System (GPS) velocity field, acquired between 2008 and 2012, that describes in some detail the interseismic deformation between 18°S and 24°S. We invert for coupling distribution on the Nazca-South America subduction interface using elastic modelling. Our measurements require that, at these latitudes, 10 to 12 mm yr−1 (i.e. 15 per cent of the whole convergence rate) are accommodated by the clockwise rotation of an Andean block bounded to the East by the subandean fold-and-thrust belt. This reduces the accumulation rate on the subduction interface to 56 mm yr−1 in this area. Coupling variations on the subduction interface both along-strike and along-dip are described. We find that the North Chile seismic gap is segmented in at least two highly locked segments bounded by narrow areas of weak coupling. This coupling segmentation is consistent with our knowledge of the historical ruptures and of the instrumental seismicity of the region. Intersegment zones (Iquique, Mejillones) correlate with high background seismic rate and local tectonic complexities on the upper or downgoing plates. The rupture of either the Paranal or the Loa segment alone could easily produce a Mw 8.0-8.3 rupture, and we propose that the Loa segment (from 22.5°S to 20.8°S) may be the one that ruptured in 1877.
ISSN: 0956-540X

hal-00941279
https://hal.archives-ouvertes.fr/hal-00941279
DOI : 10.1093/gji/ggt183

Éditeur(s) : HAL CCSD
Résumé : International audience
Necroptosis is a regulated form of cell death involved in several disease models including in particular liver diseases. Receptor-interacting protein kinases, RIPK1 and RIPK3, are the main serine/threonine kinases driving this cell death pathway. We screened a noncommercial, kinase-focused chemical library which allowed us to identify Sibiriline as a new inhibitor of necroptosis induced by tumor necrosis factor (TNF) in Fas-associated protein with death domain (FADD)-deficient Jurkat cells. Moreover, Sib inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis. By using competition binding assay and recombinant kinase assays, we demonstrated that Sib is a rather specific competitive RIPK1 inhibitor. Molecular docking analysis shows that Sib is trapped closed to human RIPK1 adenosine triphosphate-binding site in a relatively hydrophobic pocket locking RIPK1 in an inactive conformation. In agreement with its RIPK1 inhibitory property, Sib inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis. Finally, Sib protects mice from concanavalin A-induced hepatitis. These results reveal the small-molecule Sib as a new RIPK1 inhibitor potentially of interest for the treatment of immune-dependent hepatitis. © 2017 Federation of European Biochemical Societies
ISSN: 1742464X

hal-01616420
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616420
DOI : 10.1111/febs.14176
PUBMED : 28715128

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
In France, reducing social health inequalities has become an explicit goal of health policies over the past few years, one of its objectives is specifically the reduction of the perinatal mortality rate. This study investigates the association between infant mortality and social deprivation categories at a small area level in the Lille metropolitan area, in the north of France, to identify census blocks where public authorities should prioritize appropriate preventive actions. We used census data to establish a neighbourhood deprivation index whose multiple dimensions encompass socioeconomic characteristics. Infant mortality data were obtained from the Lille metropolitan area municipalities to estimate a death rate at the census tract level. We used Bayesian hierarchical models in order to reduce the extra variability when computing relative risks (RR) and to assess the associations between infant mortality and deprivation. Between 2000 and 2009, 668 cases of infant death occurred in the Lille metropolitan area (4.2 per 1,000 live births). The socioeconomic status is associated with infant mortality, with a clear gradient of risk from the most privileged census blocks to the most deprived ones (RR = 2.62, 95 % confidence interval [1.87; 3.70]). The latter have 24.6 % of families who were single parents and 29.9 % of unemployed people in the labor force versus 8.5 % and 7.7 % in the former. Our study reveals socio-spatial disparities in infant mortality in the Lille metropolitan area and highlights the census blocks most affected by the inequalities. Fine spatial analysis may help inform the design of preventive policies tailored to the characteristics of the local communities.
ISSN: 1092-7875

hal-00876255
https://hal.archives-ouvertes.fr/hal-00876255
DOI : 10.1007/s10995-013-1251-8
PUBMED : 23479336