Éditeur(s) : HAL CCSD American Society of Tropical Medicine and Hygiene
Résumé : International audience
Two cases are reported which illustrate important epidemiological aspects of lymphatic filariasis--prolonged longevity of the adult parasite and the possibility of transmission by individuals with ultra-low level microfilaremia. These cases demonstrate that people can remain carriers of microfilariae in the peripheral blood for many years without reinfection, and even those with a low level microfilaremia can constitute a significant reservoir of mosquito infection. Such cases represent one of the most serious obstacles to the eradication of lymphatic filariasis in regions where control is based on chemotherapy.
ISSN: 0002-9637

hal-00715427
https://hal.univ-antilles.fr/hal-00715427
PUBMED : 373472

Résumé : Mondialisation et cultures populaires à Barbade et Trinidad (musique, Carnaval et danse) La culture caribéenne subit de plus en plus les assauts de la mondialisation. Et la question qui se pose concerne l'impact de la mondialisation sur la culture dans la région, c'est-à- dire le passage de la culture ethnique à la mondialisation. Au cours des siècles, le Caribéen, ce métis culturel, cet individu s'est façonné au contact d'influences diverses . Il faut attendre les années 1970 pour que la Barbade et Trinidad se forgent une nouvelle identité sous l'influence du Black Power venu des Etats - Unis et du mouvement Rastafari issu de la Jamaïque. Par ailleurs, l'influence de la télévision et de la musique américaine combinée aux migrations et aux effets de la mondialisation constitue des éléments majeurs à la formation de cette nouvelle identité. Aujourd 'hui après plus de cinquante ans d'indépendance, il y a une timide appréciation de la culture locale. Timide , parce qu'à radio, on entend plus de la musique internationale (américaine, anglais) que de musique locale (calypso, soca) saufpendant le Carnaval de Trinidad et le Crop Over de Barbade. Ce que regrettent les calypsoniens qui reprochent aux radios locales de ne diffuser cette musique que pendant cette période. De la musique caribéenne, les . jeunes de Barbade et de Trinidad plébiscitentures le reggae, la dancehall, le raggasoca, la musique soca. En fait, le calypso correspond à un moment de la vie. A Trinidad, la musique indienne joue un rôle important qui correspond à la population du pays. La musique de Rihanna, l'icône du moment n'a rien de caribéen. Mais son succès phénoménal à Barbade et ailleurs permet de mieux appréhender les facettes de l'identité caribéenne, en général et en particulier, celle de Barbadien et du Trinidadien. De nos jours, les nouvelles technologies accentuent les effets de la mondialisation et contribuent à l'émergence d'une « décréolisation » pour reprendre les termes de G. Létang et d'une nouvelle identité..
Globalization and popular cultures in Barbados and Trinidad Caribbean culture is under the influence ofglobalization. The question is here the impact ofglobalization on the culture in the region . Through centuries the Caribbean man has been made through different cultures. We must wait for the years 1970 to see Barbados and Trinidad which have been made a new identity under the influence of Black Power and the Rastafari movement coming from Jamaica. After more than 50 years ofindependence, there is a shy appreciation oflocal culture . There is more international music than calypso. In Trinidad the Indian music plays an important role corresponding ta the population of the country The new technologies increase the effect of the globalization. It constitutes the rise of the "decreolisation movement".

http://www.theses.fr/2013AGUY0681/document

Résumé : Les venins sont des armes sophistiquées, utilisées par les organismes venimeux pour se défendre des prédateurs, ainsi que pour paralyser et tuer leurs proies. Mais dans la nature, le bien n’est jamais très loin du mal, les toxines venimeuses pouvant se révéler être des agents thérapeutiques efficaces. Les peptides de venins de fourmis ont donc été étudiés dans cette thèse afin de déterminer le potentiel de ces toxines pour la découverte de molécules thérapeutiques innovantes. A l’instar des autres venins d’insectes, les venins de fourmis restent peu étudiés, principalement en raison de la petite taille de ces insectes et des quantités limitées de venins disponibles. Cependant, les fourmis offrent l’avantage d’être des insectes sociaux très abondants dans tous les milieux terrestres. En collectant les venins de plusieurs individus, il est donc possible d’obtenir des quantités suffisantes de venin pour les analyses biochimiques et pharmacologiques.Afin d’assurer la reproductibilité des analyses, une identification taxonomique correcte est nécessaire. Dans cette optique, un outil de chimiotaxonomie a été développé durant cette thèse (permettant ainsi de regrouper les venins provenant de plusieurs colonies afin de compenser les faibles quantités de matériel biologique par individu ou par colonie).Ensuite, nous nous sommes intéressés aux facteurs écologiques impliqués dans la diversification des venins de fourmis. Pour cela, la toxicité et la composition des venins de fourmis ont été analysés en relation avec le polyéthisme, la spécialisation alimentaire et la spécialisation défensive.La diversité écologique des fourmis a amplement contribuée à la diversification des venins. En étudiant les venins de 82 espèces de fourmis, nous avons révélé la grande diversité structurale des toxines. Bien que la majorité des peptidomes sont composés par de petits peptides linéaires, des peptides structurés par des ponts disulfure ont été révélés dans de nombreux venins et constituent de nouvelles familles structurales de toxines.La purification de certains de ces peptides à ponts disulfure a permis leur caractérisation biochimique et l’évaluation de leur rôle biologique. Ainsi nous avons décrit un groupe de peptides neurotoxiques, baptisés les formicitoxines qui sont capables de bloquer les canaux calcium humains de type L. La commutatoxine est, quant à elle, un peptide avec un pont disulfure qui semble activer les récepteurs humains TRPV1 et TRPV3 et laisse supposer une implication dans l’induction de la douleur chez les mammifères.La grande diversité des peptides mise en évidence dans les venins, associée à la grande diversité écologique et taxonomique des fourmis, suggère que les venins de fourmis constituent un nouveau champ d’exploration prometteur pour la recherche de molécules thérapeutiques et insecticides. Les venins de fourmis s’ajoutent à la chimiothèque conséquente déjà représentée par les venins des autres animaux venimeux.
Venoms are sophisticated weapons employed by venomous organisms to ward off predators, as well as to subdue and kill prey. However, in nature, good is never far from bad and venom toxins may prove to be efficient therapeutic agents. Ant venom peptides were investigated in the course of this thesis to evaluate their potential in the discovery of novel drugs. Like other insect venoms, ant venoms remain understudied, mainly due to the small size of individual ants and, so, the limited a mount of venom available. The ecological diversity of ants has largely contributed to venom diversification. By studying the venom peptidomes from 82 ant species, we have revealed the great structural diversity of the toxins. Although the majority of the peptidomes are comprised of small and linear peptides, peptides structured by disulfide bonds were also brought to light in numerous venoms and constitute novel structural classes of toxins. The purification of some of these disulfided peptides permitted their biochemical characterization and the assessment oft heir biological functions. The enormous peptide diversity revealed among venoms combined with the great ecological and taxonomical diversity of ants suggests that ant venoms constitute a promising new source in the search for both novel drugs and insecticides. Ant venom augments the vast bioactive molecules library represented by venoms from other venomous animals.

http://www.theses.fr/2015AGUY0829/document

Éditeur(s) : HAL CCSD
Résumé : International audience
This study compared the hemorheological profile at rest and in response to a short supramaximal exercise test between sickle cell trait (SCT) carriers and a control group. Eight SCT carriers and eight control subjects performed a ramp exercise test on a cycle ergometer conducted to maximal oxygen uptake ðV_ O2maxÞ: One week later, they performed a supramaximal exercise test consisting of pedaling for 1 min at 110% V_ O2max: Blood viscosity (gb), plasma viscosity (gp), hematocrit (Hct) and red blood cell (RBC) rigidity were assessed at rest, at the end of exercise and at the 15th, 30th and 60th min of recovery. Exercise increased gb, gp and Hct above resting values in both groups and these parameters remained higher until the 15th or 30th min of recovery as compared to resting values. RBC rigidity was unchanged from baseline values in both groups during exercise and recovery. No difference was observed between the two groups for gp and Hct but gb and RBC rigidity were higher in the SCT carriers at every time point compared with the control group. The higher RBC rigidity and gb found in SCT carriers at rest and in response to a brief supramaximal exercise might constitute a risk factor for microcirculatory complications. Indeed, a short supramaximal exercise test may not be completely inoffensive for SCT carriers.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

hal-00706158
https://hal.univ-antilles.fr/hal-00706158
DOI : 10.1007/s00421-006-0155-3

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Large organic falls to the benthic environment, such as dead wood or whale bones, harbour organisms relying on sulfide-oxidizing symbionts. Nothing is known however, concerning sulfide enrichment at the wood surface and its relation to wood colonization by sulfide-oxidizing symbiotic organisms. In this study we combined in situ hydrogen sulfide and pH measurements on sunken wood, with associated fauna microscopy analyses in a tropical mangrove swamp. This shallow environment is known to harbour thiotrophic symbioses and is also abundantly supplied with sunken wood. A significant sulfide enrichment at the wood surface was revealed. A 72 h sequence of measurements emphasized the wide fluctuation of sulfide levels (0.1->100 lM) over time with both a tidal influence and rapid fluctuations. Protozoans observed on the wood surface were similar to Zoothamnium niveum and to vorticellids. Our SEM observations revealed their association with ectosymbiotic bacteria, which are likely to be sulfide- oxidizers. These results support the idea that sunken wood surfaces constitute an environment suitable for sulfide-oxidizing symbioses.
ISSN: 0141-1136

hal-00751649
https://hal.univ-antilles.fr/hal-00751649

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study constitutes one of the few works conducted on the colonization of recent lava flows by fish communities in coral reef environment. It attempted to describe the mechanisms of colonization and environmental variables infuencing the structure of communities on the lava flows of the Piton de la Fournaise volcano at Reunion Island. It also proposed some hypotheses on the mechanisms of selection and speciation of endemic species of thesouthwestern Indian Ocean region, particularly diversified on the most recent lava flows of the Piton de la Fournaise, and provided a model of distribution of environmental and fish assemblage variables in four homogeneous patterns of colonization (landscapes) retained within the study area. The results showed fish community structure strongly related to measured environmental variables, of which depth, width of the island shelf, age of the lava flow and distance to the most recent lava flow were the most influential. It also appeared that the maximum endemic species richness was measured on the shallower stations, with narrow insular shelf, located on recent lava flows, near the lava flow from the eruption of 2007 (latest volcanic event). These characteristics define a harsh environment, to which endemic species seem well-adapted due in particular to their strong demographic and dietary flexibility. Finally, the patterns of colonization were characterized by significantly different environmental variables. The four homogeneous areas, defined by two geomorphological features, basalt blocks and drop-offs, nested within two locations, inside and outside the volcanic enclosure (current caldera), hosted fish communities whose dominant diets mainly depend on the nature, the abundance and the accessibility of available food resources. Overall, the study highlights that during early stages of ecological succession, site selection by fish communities is highly dependent on environmental constraints, specially of volcanic origin, but the physical habitat selection (geomorphology, substrate rugosity, percentage of soft substrate) seems to have littleimportance, while at least on the trophic structure and the distribution of endemic species.
ISSN: 0022-0981

hal-01253768
https://hal.archives-ouvertes.fr/hal-01253768
https://hal.archives-ouvertes.fr/hal-01253768/document
https://hal.archives-ouvertes.fr/hal-01253768/file/Pinault%20et%20al.%20-%202014%20-%20Fish%20community%20structure%20in%20relation%20to%20environmen_hal.pdf
DOI : 10.1016/j.jembe.2014.06.005

Éditeur(s) : Actes de colloques Ifremer, Tahiti, French Polynesia, 20 Feb - 4 Mar 1989, n°9, chap. 1, pp.3-9
Résumé : IFREMER, a French governmental agency, is engaged in research on tropical aquaculture since 1971, with the aims to develop new activities in French overseas territories and to export French technology to foreign countries. With 80 searchers and technicians the "Centre Oceanologique du Pacifique" is the main IFREMER's centre involved in tropical aquaculture. The research has been focused on the complete control of the whole cycle: constitution of broodstock, maturation and reproduction, larval rearing, and grow-out.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1989/acte-1500.pdf
http://archimer.ifremer.fr/doc/00000/1500/

Éditeur(s) : HAL CCSD
Résumé : International audience
Until the end of the 20th century, heritage was mainly defined in the Caribbean, as in the entire world, by an european conception (linked with the formation of national identities), founded on the value of tangible heritage (rare, ancient objects, monuments and materials) as an historic proof of the value of cultures and peoples. Poets in the Caribbean hardly criticize this evidence that contributed to inferiorized people. Memory and imagination played a central role in the building of a Caribbean cultural identity. Poets tried to show how the common could rise from different patterns, diversity instead of unity, creation instead of fixity. Nevertheless, In the 21st century, frameworks are not available to deal with Caribbean heritage in its diversity (monuments, material, natural and intangible...) and complexity whereas it constitute a challenge for a sustainable society and can play a fundamental role in education as in tourism.
Jusqu'à la fin du XXe siècle, le patrimoine dans la Caraïbe comme ailleurs dans le monde, répondait principalement à une conception européenne (liée à la formation des identités nationales) fondée sur la valeur positive du patrimoine matériel comme preuve historique de la valeur des cultures et des peuples. Les poètes caribéens ont déconstruit ce cadre, instrument de l'infériorisation des individus. La mémoire et l'imagination ont joué un rôle central dans la construction d'une identité culturelle caribéenne. Ils ont tenté de montrer que le commun pouvait émerger de modèles différents, opposant à l'unique, le divers et à la fixité, la création. Cependant, au XXIe siècle, la Caraïbe ne dispose pas d'un cadre pour traiter son patrimoine dans sa diversité (patrimoine matériel, immatériel, naturel) et sa complexité alors que le patrimoine constitue un défi pour le développement durable des sociétés et peut jouer un rôle fondamental dans l'éducation et le tourisme.
Caribbean Studies Association annual conference
Port-au-Prince, Haiti

hal-01612909
https://hal.univ-antilles.fr/hal-01612909

Éditeur(s) : HAL CCSD American Society for Biochemistry and Molecular Biology
Résumé : International audience
Chronic low grade inflammation is closely linked to obesity-associated insulin resistance. To examine how administration of the anti-inflammatory compound indomethacin, a general cyclooxygenase inhibitor, affected obesity development and insulin sensitivity, we fed obesity-prone male C57BL/6J mice a high fat/high sucrose (HF/HS) diet or a regular diet supplemented or not with indomethacin (±INDO) for 7 weeks. Development of obesity, insulin resistance, and glucose intolerance was monitored, and the effect of indomethacin on glucose-stimulated insulin secretion (GSIS) was measured in vivo and in vitro using MIN6 β-cells. We found that supplementation with indomethacin prevented HF/HS-induced obesity and diet-induced changes in systemic insulin sensitivity. Thus, HF/HS+INDO-fed mice remained insulin-sensitive. However, mice fed HF/HS+INDO exhibited pronounced glucose intolerance. Hepatic glucose output was significantly increased. Indomethacin had no effect on adipose tissue mass, glucose tolerance, or GSIS when included in a regular diet. Indomethacin administration to obese mice did not reduce adipose tissue mass, and the compensatory increase in GSIS observed in obese mice was not affected by treatment with indomethacin. We demonstrate that indomethacin did not inhibit GSIS per se, but activation of GPR40 in the presence of indomethacin inhibited glucose-dependent insulin secretion in MIN6 cells. We conclude that constitutive high hepatic glucose output combined with impaired GSIS in response to activation of GPR40-dependent signaling in the HF/HS+INDO-fed mice contributed to the impaired glucose clearance during a glucose challenge and that the resulting lower levels of plasma insulin prevented the obesogenic action of the HF/HS diet.
ISSN: 0021-9258

hal-01074835
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01074835
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01074835/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01074835/file/JBC-2013-525220v2-Kristiansen-POSTPRINT.pdf
DOI : 10.1074/jbc.M113.525220

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
The embryonic development in Chione cancellata, from fertilization to straighthinge D-stage veliger larva, occurs in 24 h at 251C. Transmission (TEM) and scanning (SEM) electron microscopy show that morphogenetic processes result in a gastrula with two depressions, 4 h after fertilization (T014 h). Two hours later, one depression, located at the animal pole, develops into an open cave, the floor of which becomes the shell field, characterized by scarce microvilli, located below the lower face of the prototrochal pad. The invagination located at the vegetal pole is characterized by regular microvilli and constitutes the digestive tract. At T018 h, the late gastrula differentiates into a typical motile trochophore, possessing a well-developed prototroch delimiting anterior and posterior embryonic regions. At T019h, the shell field, located between the prototroch and the telotroch, appears as a saddle-shaped region with a wrinkled surface extending on both sides of the embryo, establishing bilateral symmetry. From TEM observations, the apical surface of the underlying cells possesses a modified glycocalyx featuring a dense pellicle overlapping the cells of the shell field. At T0112 h, the prototroch is displaced toward the anterior region by outgrowth of the shell material. TEM views show that the wrinkled surface observed with SEM corresponds to the periostracum, attached dorsally to the hinge and ventrally to the cells of the future mantle edge. At T0115 h, an alveolar matrix of proteinaceous material, which could contain calcite crystals, appears between the periostracum and the mantle. At T0124 h, prodissoconch I formation is completed and the D-stage larvae possess a calcified shell. At this stage of development, only one mantle fold is present, representing the outer fold. The periostracumsecreting cells are in contact with the marginal cells of the velum. This functional velum is composed of four bands of cilia. Our TEMobservations confirm previous descriptions of the velum ciliary bands obtained only from SEM analyses, such as described in other bivalves. The apical sense organ and the digestive tract are poorly developed. From observations at the ultrastructural level of shell differentiation in C. cancellata, we propose a new interpretation of shell differentiation, including hinge and ligament for bivalves as opposed to that described for gastropods.
ISSN: 1077-8306

hal-00755283
https://hal.univ-antilles.fr/hal-00755283
DOI : 10.1111/j.1744-7410.2006.00036.x

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
We have analyzed shear wave splitting recorded by portable and permanent broadband and long-period stations located in the eastern United States. Teleseismic shear waves (SKS, SKKS, and PKS) were used to retrieve the splitting parameters: the orientation of the fast wave polarization plane ϕ and the delay time δt. In total, 120 seismic events were processed, allowing for more than 600 splitting measurements. Within the Appalachians, stations located in the western (external) part are characterized by δt≈1s and ϕ trending N50°– 70°E in the south and central regions and N30°–40°E in the north, closely following the trend of the orogenic belt in these areas. The transition region between north and central is characterized by δt≈1–1.3 s and by E-W trending ϕ that are at a high angle to the regional geologic trend. Measurements at two stations located in the eastern (internal) part of the belt indicate very weak anisotropy. The large-scale pattern of anisotropy is not consistent with that predicted for simple asthenospheric flow beneath the plate. Splitting along the southern and eastern margins of the continent is consistent with that expected for Grenvillian deformation, an alternative model of asthenospheric flow around the cratonic keel cannot be ruled out. Within the cratonic core, the correlation between δt and lithospheric thickness suggests a lithospheric anisotropy. Smaller-length-scale variations also argue for a significant contribution of lithospheric structures. The fabric responsible for shear wave splitting may have formed during tectonic episodes that affected the eastern United States, i.e., the Grenville and Appalachian orogenies and the subsequent rifting of the North Atlantic Ocean. Our observations in the western Appalachians suggest that the anisotropy may be preserved since the Grenvillian orogeny. The absence of detectable splitting in the two stations in the eastern Appalachians is attributed to the igneous intrusions related to the Atlantic rifting. The measurements in the transition between the northern and central southern Appalachians, constitute an intriguing anomaly, whose E-W ϕ have little obvious relation to the regional surface geology. We suggest two possible causes: (1) the local dominance of asthenospheric flow, motivated by the proximity of a pervasive low-velocity anomaly and (2) lithospheric deformation in a transcontinental strike-slip fault zone active during the Appalachian collision.
ISSN: 2169-9313

hal-01388859
http://hal.univ-reunion.fr/hal-01388859
http://hal.univ-reunion.fr/hal-01388859/document
http://hal.univ-reunion.fr/hal-01388859/file/Barruol_JGR_1997.pdf
DOI : 10.1029/96JB03800

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
INTRODUCTION: In order to study social health inequalities, contextual (or ecologic) data may constitute an appropriate alternative to individual socioeconomic characteristics. Indices can be used to summarize the multiple dimensions of the neighborhood socioeconomic status. This work proposes a statistical procedure to create a neighborhood socioeconomic index. METHODS: The study setting is composed of three French urban areas. Socioeconomic data at the census block scale come from the 1999 census. Successive principal components analyses are used to select variables and create the index. Both metropolitan area-specific and global indices are tested and compared. Socioeconomic categories are drawn with hierarchical clustering as a reference to determine "optimal" thresholds able to create categories along a one-dimensional index. RESULTS: Among the twenty variables finally selected in the index, 15 are common to the three metropolitan areas. The index explains at least 57% of the variance of these variables in each metropolitan area, with a contribution of more than 80% of the 15 common variables. CONCLUSIONS: The proposed procedure is statistically justified and robust. It can be applied to multiple geographical areas or socioeconomic variables and provides meaningful information to public health bodies. We highlight the importance of the classification method. We propose an R package in order to use this procedure.
ISSN: 1475-9276

inserm-00809310
http://www.hal.inserm.fr/inserm-00809310
http://www.hal.inserm.fr/inserm-00809310/document
http://www.hal.inserm.fr/inserm-00809310/file/1475-9276-12-21.pdf
DOI : 10.1186/1475-9276-12-21

Éditeur(s) : HAL CCSD
Résumé : International audience
Here, we synthesize conceptual frameworks, applied modeling approaches, and as case studies to highlight complex social-ecological system (SES) dynamics that inform environmental policy, conservation and management. Although a set of “good practices” about what constitutes a good SES study are emerging, there is still a disconnection between generating SES scientific studies and providing decision-relevant information to policy makers. Classical single variable/hypothesis studies rooted in one or two disciplines are still most common, leading to incremental growth in knowledge about the natural or social system, but rarely both. The recognition of human dimensions is a key aspect of successful planning and implementation in natural resource management, ecosystem-based management, fisheries management, and marine conservation. The lack of social data relating to human-nature interactions in this particular context is now seen as an omission, which can often erode the efficacy of any resource management or conservation action. There have been repeated calls for a transdisciplinary approach to complex SESs that incorporates resilience, complexity science characterized by intricate feedback interactions, emergent processes, non-linear dynamics and uncertainty. To achieve this vision, we need to embrace diverse research methodologies that incorporate ecology, sociology, anthropology, political science, economics and other disciplines that are anchored in empirical data. We conclude that to make SES research most useful in adding practical value to conservation planning, marine resource management planning processes and implementation, and the integration of resilience thinking into adaptation strategies, more research is needed on (1) understanding social-ecological landscapes and seascapes and patterns that would ensure planning process legitimacy, (2) costs of transformation (financial, social, environmental) to a stable resilient social-ecological system, (3) overcoming place-based data collection challenges as well as modeling challenges.
Ocean and Coastal Management

Droits : http://creativecommons.org/licenses/by-nc-nd/
hal-01224152
https://hal-univ-perp.archives-ouvertes.fr/hal-01224152
https://hal-univ-perp.archives-ouvertes.fr/hal-01224152/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01224152/file/1-s2.0-S096456911500126X-main.pdf
DOI : 10.1016/j.ocecoaman.2015.04.018

Résumé : Cette these etudie les effets de la conversion de la foret tropicale en parcelles agricoles, sur les emissions de n2o par les sols. Ce travail est realise a l’echelle du cycle cultural sur le dispositif experimental de combi (littoral guyanais), a l’aide de mesures in situ et de simulations (modele noe) des flux de n2o. La foret tropicale a ete comparee a des parcelles de foret converties en terres agricoles par la methode ‘chop-and-mulch’. La methode de deforestation ‘chop-and-mulch’ associe coupe mecanique de la vegetation, broyage puis enfouissement des residus forestiers dans le sol. Les terres agricoles etaient soient des parcelles de prairie non paturee soient des parcelles cultivees (maïs fertilise/soja) conduites en semis conventionnel (semis apres travail du sol, sans plante de couverture) ou en semis direct (sans travail du sol, avec plantes de couverture).Les principaux resultats de cette etude sont : le sol de la foret tropicale de combi est un faible emetteur de n2o ; la conversion par la methode ‘chop-and-mulch’ de cette foret en prairie ne conduit pas a une augmentation significative des emissions de n2o entre le 19eme et le 31eme mois suivant la conversion ; la conversion de la foret en parcelles cultivees induit une augmentation significative des emissions de n2o due a la fertilisation et a la modification des parametres edaphiques (densite apparente, temperature, humidite volumique) ; la technique sans travail du sol n’engendre pas de flux de n2o significativement plus eleves que la technique avec travail du sol ; l’introduction du phenomene d’hysterese hydrique dans le modele noe presente un reel potentiel pour l’estimation des emissions de n2o in situ.
This study investigates the effects of the conversion of tropical forest to cultivation on soil n2o emissions. The study was carried out over a complete crop cycle at the experimental site combi (french guianese coast). Nitrous oxide fluxes were obtained in the field and by conducting simulations with the noe model. Undisturbed tropical rainforest was compared to rainforest that had been converted to agricultural land using the ‘chop-and-mulch’ method. The ‘chop-and-mulch’ method is a fire-free method used for vegetation clearing combining the mechanical felling of trees with the mulching of small vegetation. Agricultural land included either mowed grassland or soybean/fertilised maize crop rotation. For croplands the two cultivation practices employed were: conventional seeding (using an offset disc harrow, without cover plants) or direct seeding (no till, with cover plants).The main results of this study are: rainforest soil at combi produced low n2o emissions; rainforest converted to mowed grassland using the 'chop-and-mulch’ method did not lead to a significant increase in n2o emissions between the 19th and 31st months after conversion; the conversion of rainforest to croplands induced a significant increase in soil n2o emissions due to the application of fertiliser and the modification of soil parameters (bulk density, temperature, volumetric moisture); n2o emissions from agricultural practices with no-till were no higher than those produced by conventional agricultural practices using an offset disc harrow; and, the introduction of an hydric hysteresis into the noe model constitutes a promising improvement to estimate in situ n2o emissions.

http://www.theses.fr/2013AGUY0610/document

Résumé : L'importance des forêts tropicales dans le cycle du carbone à l'échelle planétaire est majeure, tant en terme de stock qu’en terme de flux de CO2. Plusieurs études mettent en évidence des changements au sein des forêts tropicales au cours des 20 dernières années, notamment des changements de la dynamique forestière et une augmentation de la biomasse aérienne. Les déterminants de ces variations sont aujourd’hui discutés et nous proposons ici d’apporter une contribution à ce débat. Les données utilisées dans ce travail proviennent du dispositif de suivi forestier à long terme de Paracou, Guyane Française, mis en place en 1984 et qui recouvre plus de 120 ha de forêt tropicale humide. Les données météorologiques proviennent de la tour à flux du dispositif, Guyaflux. Les mesures de diamètre proviennent de la base Guyafor pour les données annuelles et bisannuelles, et des mesures de 260 arbres à proximité de la tour à flux pour les mesures diamétriques intra-annuelles.Cette thèse se divise en deux grandes parties. La première concerne l’analyse de la biomasse du dispositif de suivi forestier de Paracou en Guyane et l’implication des changements de structure de cette forêt sur le bilan de carbone. Cette partie est constituée de deux points. (i) Quelles échelles temporelles et spatiales sont pertinentes pour analyser les composantes de structure (biomasse, aire basale et nombre de tiges) et de dynamique (croissance, recrutement et mortalité) des forêts tropicales afin de minimiser les effets d’échantillonnage ? Nous avons établi une méthodologie permettant de relier les intervalles de temps et la surface de mesure aux coefficients de variation de chacune des variables de structure et de dynamique de la forêt. (ii) Quels processus démographiques sont prépondérants dans l’explication des variations de biomasse et comment se redistribue la biomasse accumulée dans le système ? L’augmentation de la biomasse observée sur le dispositif de Paracou serait liée à la rareté des évènements de mortalité des gros arbres qui portent une part très importante de la biomasse.La deuxième partie de la thèse concerne l’analyse de l’effet du climat à moyen terme, inter et intra-annuel, et les effets directs du climat dans les changements de dynamique de la forêt. Cette partie se divise en 3 points. (i) Comment quantifier le stress hydrique en forêt tropicale humide ? Nous avons réalisé un modèle journalier de réserve en eau du sol pour les arbres en forêt tropicale. (ii) Quelles variables sont explicatives de la croissance des arbres en forêt guyanaise ? Nous avons montré que l’eau dans le sol est le facteur le plus explicatif du déterminisme climatique parmi un panel de variables climatiques. (iii) Quels traits fonctionnels sont prédicteurs de la réponse des arbres aux variations climatique ? Nous avons déterminé que des traits spécifiques, densité du bois et la hauteur maximale, ainsi que le diamètre de l'arbre au moment de la mesure, modulent la croissance des arbres en réponse au climat.
At a global scale tropical forest play a major role in term of carbon stock as well as in term of CO2 fluxes. Several studies have highlighted changes in tropical forest functioning during the last 20 years including a faster turnover and an increase of above ground biomass. The drivers of these changes are discussed and throughout this thesis we propose to contribute to this debate. We use the data from the Paracou experimental site in French Guiana established in 1984 on 120 hectares of moist tropical forest. Meteorological data come from the flux tower of the site, Guyaflux. We use annual and bisannual diameter measurements from the Guyafor database, and intra-annual diameter increments from the measurements of 260 trees near the flux tower.This thesis has two main parts. In the first part we present the biomass analysis of the Paracou permanent plots and the impact of structural changes in this forest on the carbon budget. The first part is constituted by two points. (i) Which temporal and spatial scale used to analyze the structure (biomass, basal area and stem density) and dynamics (tree growth, recruitment and mortality)components of tropical forest in order to minimized sample bias ? We establish a simple method to rely measurement interval between census and surface of measurement to the coefficient of variation of forests structure and dynamic components (ii) Which demographic process are involved in the explanation of biomass variation and how the biomass is distributed in the system ? The observed increase of biomass at Paracou could be link to the rarity of big trees mortality events. These big trees represent the larger part of the biomass. In the second part, we present the analysis of intra and inter-annual climate variation effects on forest dynamic changes. This part is divided in two points. (i) How to model drought stress in moist tropical forest ? We built a daily water balance model for tropical trees. (ii) Which climate variables explain the tree growth in guianian forests? We shown that soil water availability is the determinant factor of tree growth among a panel of climate variables. (iii) Which functional traits are involved in the tropical tree growth responses to climate? In this analysis, we determined that wood specific gravity, maximum tree height and tree diameter modulate the tree growth response to climate variations.

http://www.theses.fr/2011AGUY0481/document

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Basal cell carcinoma (BCC) is the commonest tumor in human. About 70% sporadic BCCs bear somatic mutations in the PATCHED1 tumor suppressor gene which encodes the receptor for the Sonic Hedgehog morphogen (SHH). PATCHED1 germinal mutations are associated with the dominant Nevoid Basal Cell Carcinoma Syndrome (NBCCS), a major hallmark of which is a high susceptibility to BCCs. Although the vast majority of sporadic BCCs arises exclusively in sun exposed skin areas, 40 to 50% BCCs from NBCCS patients develop in non photo-exposed skin. Since overwhelming evidences indicate that microenvironment may both be modified by- and influence the- epithelial tumor, we hypothesized that NBCCS fibroblasts could contribute to BCCs in NBCCS patients, notably those developing in non photo-exposed skin areas. The functional impact of NBCCS fibroblasts was then assessed in organotypic skin cultures with control keratinocytes. Onset of epidermal differentiation was delayed in the presence of primary NBCCS fibroblasts. Unexpectedly, keratinocyte proliferation was severely reduced and showed high levels of nuclear P53 in both organotypic skin cultures and in fibroblast-led conditioning experiments. However, in spite of increased levels of senescence associated β-galactosidase activity in keratinocytes cultured in the presence of medium conditioned by NBCCS fibroblasts, we failed to observe activation of P16 and P21 and then of bona fide features of senescence. Constitutive extinction of P53 in WT keratinocytes resulted in an invasive phenotype in the presence of NBCCS fibroblasts. Finally, we found that expression of SHH was limited to fibroblasts but was dependent on the presence of keratinocytes. Inhibition of SHH binding resulted in improved epidermal morphogenesis. Altogether, these data suggest that the repertoire of diffusible factors (including SHH) expressed by primary NBCCS fibroblasts generate a stress affecting keratinocytes behavior and epidermal homeostasis. Our findings suggest that defects in dermo/epidermal interactions could contribute to BCC susceptibility in NBCCS patients.
ISSN: 1932-6203

Droits : http://creativecommons.org/licenses/by/
hal-01257867
http://hal.upmc.fr/hal-01257867
http://hal.upmc.fr/hal-01257867/document
http://hal.upmc.fr/hal-01257867/file/journal.pone.0145369.pdf
DOI : 10.1371/journal.pone.0145369

Résumé : La nécessité d'une approche intégrée des pêches est actuellement largement affirmée, notamment par la FAO, en particulier dans le contexte des pêcheries artisanales tropicales. Ces pêcheries à petites échelles, souvent multi-spécifiques sont très importantes en termes d'emploi et de production, y compris pour la sécurité alimentaire. Néanmoins ces pêcheries et la biodiversité exploitées sont souvent marquées, d'une part, par le manque de données rendant difficile leur gestion dans le cadre d'une approche écosystémique, d'autre part, par la complexité des systèmes écologiques et économiques sous-jacents incluant interactions trophiques et techniques.Cette thèse contribue à la mise au point d'outils bioéconomiques adaptés aux petites pêcheries tropicales dans la perspective d'une gestion durable des pêches fondée sur l'approche écosystémique. Dans cette perspective, la pêcherie côtière en Guyane Française constitue un cas d'étude particulièrement fécond. La thèse propose ainsi des évaluations multi-critères, des modèles bioéconomiques complexes et des scénarios de gestion viable pour cette pêcherie.Dans un premier temps l'analyse statistique multi-variée suggère un statut global satisfaisant de la pêcherie en termes de durabilité. Cependant des différences de performance sont notées au sein de la pêcherie, notamment au niveau des zones frontalières. Aussi des améliorations dans le mode de gestion sont proposées. Ensuite, à travers la modélisation bioéconomique, les projections des différents scénarios de pêche montrent qu'à long terme le niveau d'exploitation actuel peut ne pas être en adéquation avec la future augmentation de la demande locale et qu'une perte de biodiversité peut avoir lieu. Un scénario dit de « co-viabilité » conciliant des objectifs à la fois écologique, économique et social, avec une probabilité de réalisation satisfaisante, est mis en exergue. Enfin, la comparaison des comportements optimaux en situation coopératif et non coopératif, montre dans quelle mesure la viabilité est favorisée quand les acteurs coopèrent. Au-delà du diagnostic apporté pour le cas d'étude, la méthode utilisée s'avère prometteuse dans le contexte des petites pêcheries tropicales, tandis que l'approche de « co-viabilité » permet de trouver les modalités d'exploitation dans le cadre de compromis entre durabilité écologique et socio-économique, ce que les principes de gestion halieutiques traditionnels ne permettent généralement pas.
The need for an integrated approach to fisheries is now widely affirmed, including the FAO, in particular in the context of tropical artisanal fisheries. These small-scale fisheries, often multispecies are very important in terms of production, employment and food security. However these fisheries and the exploited resources are often characterized by a lack of data making difficult their management within an ecosystem approach, and by the ecological and economic system complexities including trophic and technological interactions.This thesis aims to contribute to the development of bioeconomic tools for small tropical fisheries in a sustainable management perspective based on the ecosystem approach. In this perspective, the French Guiana coastal fishery constitutes an interesting case study. The thesis proposes multi-criteria evaluations, complex bioeconomic models and viable management scenarios for this fishery. At first, multivariate statistical analysis suggests a satisfactory overall status of the fishery in terms of sustainability. However, some performance differences are noted within the fishery, particularly at border areas. Also, management improvements are proposed. Then, through bioeconomic modeling, projections of different fishing scenarios show that, in the long term, the current exploitation level may not be consistent with the future increase of local demand and a loss of biodiversity may occur. A scenario called "co-viability" reconciling ecological, economic and social objectives, with a high probability of achievement is exhibited. Finally, the comparison of optimal behavior in cooperative and non-cooperative conditions, confirms that harvest levels are greater when actors do not cooperate. Furthermore, it is shown that the state of the ecosystem depends on the fishing strategies and the type of interaction between species. Beyond the diagnosis made for the case study, the method is promising in the context of small tropical fisheries, while the co-viability approach allows finding the exploitation conditions under which ecological and socio-economic sustainability are meet, what the conventional fisheries management generally do not allow.

http://www.theses.fr/2013AGUY0620/document

Résumé : Au début du vingtième siècle, une rupture radicale et fondatrice de modernité artistique eut lieu au Brésil. Cette modernité se démarque de celle d’Europe par la prise de conscience des distances géographiques, culturelles et politiques vis à vis de l’Europe et surtout de l’ancienne puissance coloniale, le Portugal, par la recherche de son identité à travers la multiplicité des métissages du Nouveau Monde, ses mythes et son histoire réelle décolonisée. L’avant-garde brésilienne émerge autour de 1928, à travers les Manifestes anthropophages d’Oswald de Andrade (1890-1954) qui est donc le fondateur des anthropophagies, que l’on peut définir comme un indianisme à rebours. Le ″mauvais sauvage″ exerce sa critique contre les impostures du monde. « La ″Descente anthropophagique″ n’est pas une révolution littéraire, ni sociale, ni politique, ni religieuse. Elle est tout cela à la fois ! Sa loi est simple : Ne m’intéresse que ce qui n’est pas à moi ! Loi de l’homme, loi de l’anthropophagie ! » . Elle prescrit donc la dévoration des modèles importés et leur digestion dans l’hybridation au nom de l’identité brésilienne, par déplacement de concepts freudiens : « L’anthropophagie c’est la transformation permanente du Tabou (manger de l’homme) en Totem (de l’identité brésilienne) ! » . Ici l’influence notable de la psychanalyse et de l’anthropologie est à resituer : le déplacement du tabou anthropophage demeure une transgression symbolique, une métaphore, mais la référence anthropophagique ne concerne pas que la période précolombienne, car elle se réactualise. Nous nous proposons d’étudier ce phénomène à travers quatre questions : 1°- Quelles relations existent entre l’anthropophagie, l’histoire, l’esthétique et l’idéologie ? 2°- Quelle est la place des femmes artistes brésiliennes dans l’émergence de ce mouvement, compte tenu de leur présence décisive dès l’origine ?3°- Compte tenu de la résurgence rhizomique de l’anthropophagie dans la 2e moitié du XXe siècle, y compris jusqu’à aujourd’hui, quelle est la place des femmes artistes dans ce phénomène ? Y a-t-il continuité avec l’époque fondatrice ?4°- Etant donné ce qui précède, peut-on déduire qu’il existe un courant spécifiquement féminin dans l’anthropophagie d’hier et d’aujourd’hui ? Quelle est son importance réelle ? Quelles sont ses relations et postures par rapport à la postmodernité et à la mondialisation de l’art contemporain ?
At the beginning of the twentieth century, in Brazil, a radical artistic rupture took place, which marked the beginning of a new era. The resulting modernity differed from its European counterpart by the awareness of geographical, cultural and political distances that alienated Brazil from Europe and more specifically from its former colonial owner, Portugal. Brazilian modernity sought to define its identity through important basic elements that constitute the stuff that the New World is made of: cross-breeding, mythology and post-colonialism. The Brazilian avant-garde emerged around 1928 with the publication of The Anthropophagy Manifesto by Oswald de Andrade (1890-1954), who is thus the founder of the Anthropophagy, that we can define as a backward step into a reinvented form of ″Amerindianness″. The ″bad savage″ voices his criticism against impostures of the world. « Anthropophagy art is not a literary revolution, nor is it a social plea, nor a political pamphlet, nor a religious tract. It is all these things at the same time. Its law is simple: everything that is not me is of interest to me. The law of men is the law of Anthropophagy ». It thus prescribes eating up imported models and digesting them through the process of hybridization in the name of Brazilian identity. By displacing Freudian concepts, «Anthropophagy is the permanent transformation of the Taboo (man-eating) into a Totem (Brazilian identity) ». The permeating influences of psychoanalysis and anthropology need to be put in perspective: the displacement of the anthropophagous taboo remains a symbolic act of transgression, a metaphor, but the anthropophagic reference does not concern the pre-Columbian period, because it is updated. We propose to study this phenomenon through four questions: 1°- What are the relations between Anthropophagy, history, esthetics and ideology? 2°- What is the place of women Brazilian artists in the emergence of this movement, taking into account their decisive presence right from the start? 3°- Taking into account the resurgence of Anthropophagy from the second half of the 20th century onwards, what is the place of women artists in this phenomenon? Are they pursuing the same interests as the founders of the movement?4°- Can we deduce that there exists a specifically female genre within the anthropophagic movement of yesterday and of today? If so, what is its relevance? Where does it stand with respect to the contemporary concepts of post-modernity and globalization in the present-day art world?

http://www.theses.fr/2014AGUY0766/document

Éditeur(s) : HAL CCSD
Résumé : International audience
Background: Mounier-Kuhn syndrome (MKS) is a rare disorder characterized by enlargement of the trachea and main bronchi and associated with recurrent respiratory tract infections. Objective: This multicenter, retrospective study was carried out to describe respiratory conditions associated with tracheobronchomegaly. Methods: Nine institutions involved in the ‘Groupe d'Endoscopie de Langue Française' (GELF) participated in this study. A standard form was used to record patient characteristics, treatments and follow-up from medical charts. Results: Seventeen patients, 53% male, aged 58 ± 18 years at diagnosis were included. Recurrent infections revealed MKS in 88% of cases. Main comorbid conditions were diffuse bronchiectasis in 88% of patients and tracheobronchomalacia in 67% of cases. The exacerbation rate was 1.5 exacerbations/patient/year. The main non-respiratory morbid condition was gastroesophageal reflux disease in 29% of cases. Interventional bronchoscopy was performed in seven patients (41%), consisting of laser (n = 2) and tracheal stenting (n = 5). Complications related to stents were observed in 80% of cases with a mean stent duration of 8 months. Four deaths, including three due to respiratory causes, occurred during follow-up. Conclusions: This is the largest series of MKS reported in the literature, showing that bronchiectasis and tracheobronchomalacia are the main associated morbid conditions that constitute a challenge for treatment.
Respiration

hal-01331182
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01331182
DOI : 10.1159/000445029
PUBMED : 27022925

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Introduction In order to study social health inequalities, contextual (or ecologic) data may constitute an appropriate alternative to individual socioeconomic characteristics. Indices can be used to summarize the multiple dimensions of the neighborhood socioeconomic status. This work proposes a statistical procedure to create a neighborhood socioeconomic index. Methods The study setting is composed of three French urban areas. Socioeconomic data at the census block scale come from the 1999 census. Successive principal components analyses are used to select variables and create the index. Both metropolitan area-specific and global indices are tested and compared. Socioeconomic categories are drawn with hierarchical clustering as a reference to determine "optimal" thresholds able to create categories along a one-dimensional index. Results Among the twenty variables finally selected in the index, 15 are common to the three metropolitan areas. The index explains at least 57% of the variance of these variables in each metropolitan area, with a contribution of more than 80% of the 15 common variables. Conclusions The proposed procedure is statistically justified and robust. It can be applied to multiple geographical areas or socioeconomic variables and provides meaningful information to public health bodies. We highlight the importance of the classification method. We propose an R package in order to use this procedure.
International Journal for Equity in Health

hal-00854028
https://hal.archives-ouvertes.fr/hal-00854028
https://hal.archives-ouvertes.fr/hal-00854028/document
DOI : 10.1186/1475-9276-12-21