Éditeur(s) : HAL CCSD
Résumé : Hepatitis C virus (HCV) is one of the leading causes of hepatocellular carcinoma. Therapeutic treatment against the virus has been recently improved by a tritherapy including pegylated interferon, ribavirin and antiviral protease. Nevertheless, the importance of side effects and the emergence of resistant mutants require the development of new antivirals. In this context, our team has recently discovered that Type III phosphatidylinositol 4-kinases (PI4KIIIα and PI4KIIIβ) are essential for the propagation of the virus in a human hepatic cell line at the entry and replication steps. To further characterize these potential therapeutic targets, we investigate the implication of these kinases during the HCV entry, using primary human hepatocytes, a model closer to the in vivo conditions. Two lines of research were developed: Verification of the importance of the kinase activity of PI4KIIIs during HCV entry in primary human hepatocytes, through a chemical approach; Validation of the involvement of these kinases and their enzymatic activity during viral entry through a genetic approach based on RNA interference and phenotype rescue. In parallel, we studied the expression of PI4KIIIα in liver diseases. Our results suggest the involvement of PI4KIIIα in HCV entry; the involvement of PI4KIIIIβ needs to be confirmed. The analysis of PI4KIIIα expression in hepatocellular carcinoma led us to propose this kinase as a new molecular marker, which could improve the already established prognosis models and could lead to the development of new therapeutic approaches.
Le virus de l’hépatite C (VHC) est l’un des principaux facteurs étiologiques du carcinome hépatocellulaire. Le traitement des hépatites virales C a été récemment amélioré grâce à une trithérapie (interféron, ribavirine et anti-protéase virale). Néanmoins l’importance des effets secondaires et l’émergence de mutants résistants nécessitent de découvrir de nouveaux antiviraux. Dans ce contexte, notre équipe a récemment découvert que les phosphatidylinositol 4-kinases de type III (PI4KIIIα et PI4KIIIβ) étaient indispensables à la propagation du virus dans une lignée hépatique humaine, et ce, à 2 étapes de son cycle biologique : l’entrée et la réplication. L’objectif du présent travail était de poursuivre la validation de ces nouvelles cibles thérapeutiques potentielles, en approfondissant nos connaissances sur la dépendance du virus à l’égard de ces kinases au cours de son entrée. Pour cela, nous avons utilisé le modèle des hépatocytes humains primaires, système in vitro plus proche du contexte physiologique que les modèles utilisés jusqu’à présent et qui étaient basés sur l’exploitation de lignées. Deux axes ont été développés : Vérification de l’importance de l’activité kinase des PI4KIIIs au cours de l’entrée du VHC dans les hépatocytes humains primaires, à travers une approche chimique ; Validation de l’implication de ces kinases et de leur activité enzymatique au cours de l’entrée virale grâce à une approche génétique basée sur l’ARN interférence et la restauration de phénotype. En parallèle, nous avons étudié l’expression de PI4KIIIα au cours de pathologies hépatiques. Nos résultats suggèrent une implication de PI4KIIIα au cours de l’entrée du VHC dans les hépatocytes humains primaires, mais restent à confirmer quant à l’implication de PI4KIIIβ. Par ailleurs, l’analyse de l’expression de PI4KIIIα dans le carcinome hépatocellulaire (CHC) conduit à proposer cette kinase comme un nouveau marqueur moléculaire, qui pourrait améliorer les modèles de pronostic déjà établis et pourrait conduire au développement de nouvelles approches thérapeutiques pour les patients atteints d’un CHC, quelque soit l’étiologie.
https://tel.archives-ouvertes.fr/tel-00950335

Droits : info:eu-repo/semantics/OpenAccess
NNT : 2013REN1B006
tel-00950335
https://tel.archives-ouvertes.fr/tel-00950335
https://tel.archives-ouvertes.fr/tel-00950335/document
https://tel.archives-ouvertes.fr/tel-00950335/file/ILBOUDOAdeodat.pdf

Éditeur(s) : HAL CCSD
Résumé : This thesis is devoted to the study of the geodynamic evolution of the panafrican belt in NW Angola, lying on the western margin of the Congo craton. This orogenic belt, resulting from the late neoproterozoic - early paleozoic convergence of the São Francisco and Congo cratons, can be subdivided into two main domains: 1) an eastern foreland made of folded neoproterozoic sediments and 2) a western hinterland made of magmatic and metamorphic rocks. Our structural, petrological, geochemical and geochronological studies lead to the recognition of two main units within this hinterland : 1) an upper eastern unit made of gneiss and micaschists (PTmax : 8-12 kbar, 650-680°C) that preserves D1 deformation structures related to the ENE transport of nappes and 2) a western lower unit made of gneiss and migmatites (P-Tmax : 7-9 kbar, 700-750°C) that were affected by a polyphased deformation. Our geochronological study shows that this belt contains ~2Ga old granites that were involved in a polyphased panafrican evolution between 540 Ma for syn-D1 peak metamorphic conditions and 480 Ma for the last stages of recrystallization and exhumation of high grade rocks. The synthesis of all data leads to a precise reconstruction of P-T-D-t paths in both tectonometamorphic units and to comparison of this panafrican belt with similar belts distributed on both sides of the Atlantic ocean. This work attests of the complexity of the geodynamic processes resulting in the Gondwana assembly and implying both large cratonic landmasses and intercalated microplates.
Cette thèse est consacrée à l'étude de l'évolution géodynamique de la chaîne panafricaine au NW de l'Angola, sur la marge occidentale du craton du Congo. Ce segment orogénique, conséquence de la convergence des cratons du São Francisco et du Congo à la fin du Néoprotérozoïque et début du Paléozoïque, peut être subdivisé en un domaine externe plissé et peu métamorphique et un domaine interne formé de roches magmatiques et métamorphiques. Les études structurales, pétrologiques, géochimiques et géochronologiques conduisent à distinguer deux unités principales dans le domaine interne : - l'unité supérieure de gneiss et micaschistes (P-Tmax : 8-12 kbar, 650-680°C) dont la déformation D1 est synchrone de la mise en place des nappes vers l'ENE; - l'unité inférieure dans la partie occidentale constituée de gneiss et migmatites (P-Tmax : 7-9 kbar, 700-750°C) affectés par une déformation polyphasée. L'étude géochronologique démontre l'existence de protolithes granitiques datés à ~2 Ga impliqués dans l'orogénèse pan africaine caractérisée par une histoire polyphasée entre 540 Ma pour le pic du métamorphisme syn-D1 et 480 Ma pour les dernières phases de recristallisation et d'exhumation des roches métamorphiques de haut grade. La synthèse des données permet ainsi de reconstruire précisément les deux chemins P-T-D-t de ces deux unités tectono-métamorphiques et de comparer ce segment panafricain à ceux présents de part et d'autre de l'Atlantique Sud. Ce travail témoigne de la complexité des processus géodynamiques de convergence amenant à l'assemblage du Gondwana impliquant à la fois de larges masses cratoniques et des microplaques intercalées entre ces masses.
https://tel.archives-ouvertes.fr/tel-00770757

Droits : info:eu-repo/semantics/OpenAccess
tel-00770757
https://tel.archives-ouvertes.fr/tel-00770757
https://tel.archives-ouvertes.fr/tel-00770757/document
https://tel.archives-ouvertes.fr/tel-00770757/file/these2012-Nsungani.pdf

Éditeur(s) : HAL CCSD Oxford University Press (OUP): Policy B
Résumé : International audience
AIMS: Indications for surgery in acute infective endocarditis (IE) are detailed in guidelines, but their application is not well known. We analysed the agreement between the patient's attending physicians and European Society of Cardiology guidelines regarding indications for surgery. We also assessed whether surgery was performed in patients who had an indication. METHODS AND RESULTS: From the 2008 prospective population-based French survey on IE, 303 patients with definite left-sided native IE were identified. For each case, we prospectively recorded (i) indication for surgery according to the attending physicians and (ii) indication for surgery according to guidelines. Surgery was indicated in 194 (65%) patients according to attending physicians and in 221 (73%) according to guidelines, while 139 (46%) underwent surgery. Agreement was moderate between attending physicians and guidelines (kappa 0.41-0.59) and between indication according to guidelines and the performance of surgery (kappa 0.38). Of the 90 (30%) patients not operated despite indication, contraindication to surgery was reported by the attending physicians in 42 (47%), and indication was not identified in 48 (53%). One-year survival was 76% in patients with indication and surgery performed (n = 131), 69% in patients without indication and no surgery (n = 74), 56% in patients with identified indication and contraindication to surgery (n = 42), and 60% in patients with no identified indication (n = 48; P = 0.059). CONCLUSION: Cardiac surgery during acute IE was recommended in almost three out of four patients, although fewer than half were actually operated. Indication was not acknowledged by the attending physicians in one out of six patients
ISSN: 0195-668X

hal-01255874
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01255874
DOI : 10.1093/eurheartj/ehv650
PUBMED : 26685134

Éditeur(s) : Wiley / Blackwell
Résumé : For the first time, a deep seismic data set acquired in the frame of the Algerian-French SPIRAL program provides new insights regarding the origin of the westernmost Algerian margin and basin. We performed a tomographic inversion of traveltimes along a 100-km-long wide-angle seismic profile shot over 40 ocean bottom seismometers offshore Mostaganem (Northwestern Algeria). The resulting velocity model and multichannel seismic reflection profiles show a thin (3-4 km thick) oceanic crust. The narrow ocean-continent transition (less than 10 km wide) is bounded by vertical faults and surmounted by a narrow almost continuous basin filled with Miocene to Quaternary sediments. This fault system, as well as the faults organized in a negative-flower structure on the continent side, marks a major strike-slip fault system. The extremely sharp variation of the Moho depth (up to 45 +/- 3 degrees) beneath the continental border underscores the absence of continental extension in this area. All these features support the hypothesis that this part of the margin from Oran to Tenes, trending N65-N70 degrees E, is a fossil subduction-transform edge propagator fault, vestige of the propagation of the edge of the Gibraltar subduction zone during the westward migration of the Alboran domain.
Geophysical Journal International (0956-540X) (Wiley / Blackwell), 2015-02 , Vol. 200 , N. 2 , P. 1027-1043

Droits : The Authors 2014. Published by Oxford University Press on behalf of The Royal Astronomical Society
http://archimer.ifremer.fr/doc/00255/36670/35278.pdf
http://archimer.ifremer.fr/doc/00255/36670/35279.pdf
DOI:10.1093/gji/ggu454
http://archimer.ifremer.fr/doc/00255/36670/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The basement of central Madagascar displays two contrasted structural patterns. The first one (D1) is characterized by north-striking foliations that are gently dipping to the west and carry W- to WSW-plunging lineations, whereas the second one (D2) is characterized by steeper foliations that are striking to the NNE and lineations that are either subhorizontal or gently plunging to the SSW. The younger pattern is related to late-Panafrican tectonics along the major Angavo shear zone that is about 1000 km in length and 40 km in width with apparently little offset. Deformation in the Angavo zone induced interference folding on both sides. The D2 event is characterized by low pressures (ca 400 MPa) and high temperatures (up to 790 degrees C) responsible for prograde granulite facies conditions, that resulted from heat transfer due to magma and fluid advection in the Angavo shear zone. The D2 event is pinned at 550 +/- 11 Ma by a new monazite age from a reoriented Andringitrean granite near Ankaramena. A new suite of amphibole and biotite Ar-Ar geochronological data enables to retrace the thermochronogical evolution inside and outside the Angavo shear zone. Combined with new structural results from the western interference zone. these ages yield a better understanding of the late-Panafrican history of central Madagascar. No diachronism is observed along the strike of the Angavo shear zone. Conversely, amphibole and especially biotite ages decrease from West to East, i.e. towards the shear zone. These new ages range from 511 to 469 Ma. A 1-D conductive model constrains the thermal effect in relation with the Angavo shear zone to be restricted to a lateral distance of ca 60 km (in map view) for a maximum heating duration of 20 Myr. This is in agreement with the Ar-Ar data and with the width of the observed interference zone. Following this episode of deformation and heat transfer, the estimated cooling rates of the Angavo shear zone range from to 15 to 6 degrees C/Myr, respectively before and after 515 Ma. A post-collision intracontinental setting is suggested for the Angavo shear zone, which is regarded as a remote effect of the Kuunga Orogeny between India and Antarctica.
ISSN: 0040-1951

hal-00463507
https://hal.archives-ouvertes.fr/hal-00463507
DOI : 10.1016/j.tecto.2009.03.009

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
We analyze the kinematics of fault tip folding at the front of a fold-and-thrust wedge using a sandbox experiment. The analog model consists of sand layers intercalated with low-friction glass bead layers, deposited in a glass-sided experimental device and with a total thickness h = 4.8 cm. A computerized mobile backstop induces progressive horizontal shortening of the sand layers and therefore thrust fault propagation. Active deformation at the tip of the forward propagating basal décollement is monitored along the cross section with a high-resolution CCD camera, and the displacement field between pairs of images is measured from the optical flow technique. In the early stage, when cumulative shortening is less than about h/10, slip along the décollement tapers gradually to zero and the displacement gradient is absorbed by distributed deformation of the overlying medium. In this stage of detachment tip folding, horizontal displacements decrease linearly with distance toward the foreland. Vertical displacements reflect a nearly symmetrical mode of folding, with displacements varying linearly between relatively well defined axial surfaces. When the cumulative slip on the décollement exceeds about h/10, deformation tends to localize on a few discrete shear bands at the front of the system, until shortening exceeds h/8 and deformation gets fully localized on a single emergent frontal ramp. The fault geometry subsequently evolves to a sigmoid shape and the hanging wall deforms by simple shear as it overthrusts the flat ramp system. As long as strain localization is not fully established, the sand layers experience a combination of thickening and horizontal shortening, which induces gradual limb rotation. The observed kinematics can be reduced to simple analytical expressions that can be used to restore fault tip folds, relate finite deformation to incremental folding, and derive shortening rates from deformed geomorphic markers or growth strata.
ISSN: 2169-9313

hal-00138061
https://hal.archives-ouvertes.fr/hal-00138061
https://hal.archives-ouvertes.fr/hal-00138061/document
https://hal.archives-ouvertes.fr/hal-00138061/file/Bernard_et_al-2007-Journalsur Geophysical_Research__Solid_Earth_%281978-2012%29.pdf
DOI : 10.1029/2005JB004149

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Vascular resistance and tissue perfusion may be both affected by impaired vascular function and increased blood viscosity. Little is known about the effects of vascular function on the occurrence of painful vaso-occlusive crises (VOC) in children with sickle cell anemia (SCA). The aim of the present study was to determine which side of the balance (blood viscosity or vascular function) is the most deleterious in SCA and increases the risk for frequent hospitalized VOC. Microvascular function, microcirculatory oxygenation and blood viscosity were determined in a group of 22 SCA children/adolescents at steady state and a group of 13 healthy children/adolescents. Univariate analyses demonstrated blunted microvascular reactivity during local thermal heating test and decreased microcirculatory oxygenation in SCA children compared to controls. Multivariate analysis revealed that increased blood viscosity and decreased microcirculatory oxygenation were independent risk factors of frequent VOC in SCA. In contrast, the level of microvascular dysfunction does not predict VOC rate. In conclusion, increased blood viscosity is usually well supported in healthy individuals where vascular function is not impaired. However, in the context of SCA, microvascular function is impaired and any increase of blood viscosity or decrease in microcirculatory oxygenation would increase the risks for frequent VOC.
ISSN: 1079-9796

hal-01668335
https://hal.univ-antilles.fr/hal-01668335
DOI : 10.1016/j.bcmd.2015.10.005

Éditeur(s) : HAL CCSD Éditions de la Maison des sciences de l'homme
Résumé : International audience
For over a century, the complementary nature of fishing and farming activities in the floodplain of the Rufiji River (Tanzania) has formed the basis of the economy in its villages. Starting in the 1970s, the fishery evolved from a seasonal activity practiced on foot during flooding and using traditional traps to year-round dugout canoe operated lake fisheries using nets.The paper analyses the drivers of this change. After having rejected the simplistic technocratic hypothesis that technical innovation equals progress, the paper examines the relevance of the productivity of the different fishing techniques in the light of the evolution of the role of fisheries in the village economy. During the change-over period, the national and international economy deprives the villages of their main habitual sources of cash income. In the absence of any alternative, fisheries imposed themselves as the unique source of cash income, a function they can only fulfil if practiced year-round and this can only be achieved using canoes and nets. However, the perception of the causes of these changes in the villages is differentiated. For those who initiated the change-over, and who are now of an advanced age, the main driver of the transition to nets was the empowerment of the youth versus the elders. Such an interpretation resonates well with the economic determinants. However, it requires considering the modernisation process as a contextualised multi-sided expression of market globalisation.
Depuis plus d’un siècle, l’économie des villages de la plaine inondable du Rufiji (Tanzanie) est fondée sur la complémentarité des activités agricoles et des activités halieutiques. À partir de la fin des années 1970, les pêches traditionnelles à la nasse, pratiquées à pied saisonnièrement lors de la crue annuelle, sont supplantées par les pêches embarquées (pirogues monoxyles) au filet dans les lacs, pratiquées elles toute l’année. L’article s’interroge sur les déterminants de cette substitution.Après avoir rejeté l’hypothèse techniciste vulgaire qui voudrait que l’innovation technique soit synonyme de progrès, la pertinence du critère de productivité des différentes techniques de pêche est examinée à la lumière de l’évolution de la place des activités halieutiques dans l’économie villageoise. Il apparaît qu’à partir de cette époque, l’évolution économique nationale et internationale prive les villageois de leurs principales ressources monétaires habituelles. En l’absence de toute alternative, la pêche s’impose alors comme unique source de revenu monétaire, une fonction qu’elle ne peut remplir qu’à condition d’être pratiquée tout au long de l’année, ce que seules les techniques au filet permettent. Cependant, les représentations villageoises des causes de la généralisation de la pêche au filet sont différentes. Pour ceux d’entre eux, aujourd’hui très âgés, qui furent les pionniers de cette innovation, c’est le souci d’émancipation des cadets vis-à-vis des aînés qui aurait été le moteur de l’adoption de techniques de pêche au filet. Ce point de vue entre en résonance avec les déterminations économiques à condition de considérer le processus de modernisation comme manifestation multiforme contextualisée de la mondialisation marchande.
ISSN: 0248-6016

hal-01344410
https://hal.univ-antilles.fr/hal-01344410
https://hal.univ-antilles.fr/hal-01344410/document
https://hal.univ-antilles.fr/hal-01344410/file/Pauletal2015Version_Def.pdf

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Avril 2011. L’agitation dans les rues est le signe qu’un événement capital pour l’avenir du pays se prépare : Raoul Castro a convoqué la réunion du 6e congrès du Parti Communiste Cubain. Après des années de revendication d’un système social égalitaire échappant à la tutelle étasunienne, les structures économiques de la perle des Caraïbes sont remises en question. L’arrivée des printemps arabes, qui symbolisent la révolte des peuples vis-à-vis d’une gouvernance politique et économique autoritaire et rigide, n’est probablement pas étrangère à ce soudain besoin de modifier les structures économiques existantes à Cuba. Au menu, ce sont 291 mesures qui sont annoncées pour améliorer le quotidien des cubains, dont le salaire moyen mensuel est de 12 euros. Quant à la relation qu’entretient Cuba avec l’UE, elle revêt aujourd’hui une dimension surtout bilatérale : la position commune de 1996 n’a en effet jamais été modifiée, les Etats Membres adoptant une attitude différente selon les relations qu’ils entretiennent avec Cuba, tant d’un point de vue politique qu’historique.
April, 2011. The excitement in streets is the sign that a major event for the future of the country gets ready: Raoul Castro convened the meeting of the 6th congress of the Cuban Communist Party. After years of defending an equalitarian social system escaping the American guardianship, the economic structures of the pearl of Caribbean islands are questioned. The arrival of Arab Springs, which symbolize the revolt of the peoples towards authoritarian and stiff political and economic governance, is most probably linked to this sudden need to modify the economic structures existing in Cuba. To the menu, 291 measures are announced to improve the everyday life of Cubans, the monthly average wage of which is 12 euro. As for the relation which maintains Cuba with the EU, it takes on an especially bilateral dimension today: the common position of 1996 was modified indeed never, Member States adopting a different attitude according to the relations which they maintain with Cuba, from a political point of view as well as from a historic one.
Abril de 2011. La agitación en las calles testimonia que un evento capital para el futuro del país está preparándose: Raúl Castro convoco la reunión del 6to congreso del Partido Comunista Cubano. Después de anos reivindicando un sistema social igualitario que escapó a la tutela estadounidense, las estructuras económicas de la perla del Caribe están siendo cuestionadas. La llegada de las primaveras árabes, símbolo de la rebelión de los pueblos frente de una gobernanza política y económica autoritaria y rígida, probablemente no es ajena extranjera a esta necesidad súbita de modificar las estructuras económicas existentes en Cuba. Como parte del programa, 291 medidas son anunciadas para mejorar la vida diaria del cubano, cuyo salario medio mensual es de 12 euros. En cuanto a la relación que tiene Cuba con la UE, reviste hoy una dimensión sobre todo bilateral: en efecto, la posición común de 1996 no ha sido modificada, dado que los Estados Miembros adoptan una actitud diferente según las relaciones que mantienen) con Cuba, tanto desde un punto de vista político como histórico.
Cuba
Martinique

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.6297
http://journals.openedition.org/etudescaribeennes/6297

Éditeur(s) : HAL CCSD Presse Universitaire de Nancy
Résumé : International audience
Lorsqu’il apparaît au début des années 1980, le sida suscite l’effroi. Quel est ce mal inconnu qui renoue avec les anciennes épidémies mortelles que les progrès de la science avaient, dans la seconde moitié du 20e siècle, permis d’éradiquer ? Expression d’un mal renvoyant aux vieilles peurs, il devient vite une maladie de la marge et de la honte… Si l’infection au VIH est depuis bientôt deux décennies l’objet de traitements thérapeutiques efficaces, elle demeure néanmoins fréquemment dissimulée, y compris à la famille et aux proches. En Guadeloupe, cette dissimulation est souvent drastique. Car ici, le stigmate associé à l’infection revêt une force et une signification particulières. Pourquoi ? Cet ouvrage entend montrer combien l’expérience du VIH s’élabore dans un rapport à la prise en charge sanitaire marqué par la situation post-coloniale. Pour ce faire, il procède en plusieurs étapes. La première, qui repose sur l’analyse des bases politico-administratives et épistémologiques de la prise en charge, souligne les continuités qui s’opèrent avec le regard porté sur la lèpre (qui reste une préoccupation de santé publique jusqu’au début des années 1970 aux Antilles françaises) et le rôle joué par l’épidémiologie. La deuxième, qui se centre sur l’étude de la structuration de la prise en charge associative, montre la dépendance de cette dernière à l’égard des logiques institutionnelles. Les enjeux et tensions propres au vécu du VIH ne sont finalement appréhendés que dans un troisième et dernier temps, à la lumière de cette mise en contexte socio-historique. Ils apparaissent alors à la fois comme l’effet des traces laissées par l’imaginaire colonial (véhiculé par la culture impériale) et des dispositions socioculturelles produites en situation post-coloniale.
https://hal.archives-ouvertes.fr/hal-01681529

ISBN : 978-2-8143-0242-6
hal-01681529
https://hal.archives-ouvertes.fr/hal-01681529

Éditeur(s) : HAL CCSD Station Biologique
Résumé : International audience
The embryonic development of Tivela mactroides, from fertilization to straight-hinge veliger D-stage larva occurs in 18 hours at 25°C. Scanning electronic observations show that morphogenetic processes result in a gastrula with two depressions 4 hours after fertilization (T0 + 4h). Two hours later, one depression, located at the animal pole, develops into an open cave, the floor of which becomes the shell field located below the lower face of the prototrochal pad. The invagination located at the vegetal pole features the blastopore. At T0 + 6h, the late gastrula has differentiated into a typical motile trochophore with a shell field synthetizing the organic part of the shell. At T0 + 8h, the shell field, located between the prototroch and the telotroch, appears as a saddle-shaped region with a wrinkled surface extending on both sides of the embryo, establishing bilateral symmetry. At T0 + 12h, the prototroch slides toward the anterior region by outgrowth of the shell material. At T0 + 18h, the prodissoconch I formation is completed and the D-stage larvae possess a calcified shell. At this stage of development, the functional velum is composed of four bands of cilia. Our observations seem to confirm the interpretation of shell differentiation proposed recently by Mouëza et al. (2006) for bivalves even if Transmission Electronic observations will be necessary to validate definitively such a model in the Meretricinae sub-family.
ISSN: 0007-9723

hal-00753022
https://hal.univ-antilles.fr/hal-00753022

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Despite the increasing importance of cruise tourism worldwide, very little is known about the lives of cruise-ship employees, and how they use their free time at the ports of call. This paper presents the results of a small-scale exploratory research on the activities of cruise crew and staff members on the island of Cozumel, Mexico, an important port of call for Caribbean routes. Conducted in 2009, qualitative research for this paper included participant observation and several informal conversations and semi-structured interviews with twenty cruise-ship employees and six owners and employees of local businesses. Our conclusions confirm other authors' findings and provide fresh information on the factors that determine these individuals' choices of activities, places and company. Availability of time and money depends on each worker's place in the labor hierarchy, but choices are also influenced by cultural background. More in-depth research will be needed at the demand as well as the offer sides to complement these preliminary findings.
Malgré l'importance croissante du tourisme de croisière dans le monde, on sait très peu sur la vie des employés des navires de croisière, et comment ils utilisent leur temps libre dans les ports d'escale. Cet article présente les résultats d'une recherche exploratoire à petite échelle sur les activités de l'équipage et le staff de croisière sur l'île de Cozumel, au Mexique, un important port d'escale pour les voyages dans les Caraïbes. Réalisée en 2009, la recherche qualitative pour ce document comprenait l'observation participante, plusieurs conversations informelles et des entretiens semi-structurés avec vingt employés des navires de croisière et avec six propriétaires et employés des entreprises locales. Nos résultats confirment les conclusions d'autres auteurs mais apportent aussi de nouvelles informations sur les facteurs qui déterminent les choix individuelles concernant les activités, les lieux et ceux qui les accompagnent. La disponibilité de temps et d'argent, liées à la position de chaque travailleur dans la hiérarchie de l'emploi, sont importants, mais les choix sont également influencés par leur culture. Des investigations plus détaillées sont nécessaires en ce qui concerne l'offre et la demande pour compléter ces résultats préliminaires.
A pesar de la creciente importancia del turismo de cruceros en todo el mundo, se sabe muy poco sobre la vida de los empleados de cruceros, y cómo utilizan su tiempo libre en los puertos de escala. Este trabajo presenta los resultados de una investigación exploratoria a pequeña escala sobre las actividades de la tripulación de los cruceros en la isla de Cozumel, México, un puerto de escala importante para las rutas del Caribe. Realizado en 2009, la investigación cualitativa para este trabajo incluyó la observación participativa, varias conversaciones informales y entrevistas semi-estructuradas con veinte empleados de cruceros y seis propietarios y empleados de empresas locales. Nuestras conclusiones confirman las conclusiones de otros autores y aportan además nuevos datos sobre los factores que determinan las elecciones que se hace con respecto a las actividades, los lugares y la compañía. Disponibilidad de tiempo y dinero, relacionados con la posición de cada trabajador en la jerarquía laboral, son importante pero las opciones también están influidas por su cultura. Más investigación en profundidad se necesitará con respecto a la demanda, así como con respecto a la oferta, para complementar estos resultados preliminares.
Cozumel
Mexique

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.5133
http://journals.openedition.org/etudescaribeennes/5133

Éditeur(s) : HAL CCSD American Physical Society
Résumé : International audience
Using contact dynamics simulations, we compare the effect of rolling resistance at the contacts in granular systems composed of disks with the effect of angularity in granular systems composed of regular polygonal particles. In simple shear conditions, we consider four aspects of the mechanical behavior of these systems in the steady state: shear strength, solid fraction, force and fabric anisotropies, and probability distribution of contact forces. Our main finding is that, based on the energy dissipation associated with relative rotation between two particles in contact, the effect of rolling resistance can explicitly be identified with that of the number of sides in a regular polygonal particle. This finding supports the use of rolling resistance as a shape parameter accounting for particle angularity and shows unambiguously that one of the main influencing factors behind the mechanical behavior of granular systems composed of noncircular particles is the partial hindrance of rotations as a result of angular particle shape.
ISSN: 1539-3755

hal-00594891
https://hal.archives-ouvertes.fr/hal-00594891
https://hal.archives-ouvertes.fr/hal-00594891/document
https://hal.archives-ouvertes.fr/hal-00594891/file/Estrada2010ReSubmitV2.pdf
ARXIV : 1105.4418

Éditeur(s) : HAL CCSD American Association for the Advancement of Science
Résumé : International audience
Large earthquakes produce crustal deformation that can be quantified by geodetic measurements, allowing for the determination of the slip distribution on the fault. We used data from Global Positioning System (GPS) networks in Central Chile to infer the static deformation and the kinematics of the 2010 moment magnitude (M-w) 8.8 Maule megathrust earthquake. From elastic modeling, we found a total rupture length of similar to 500 kilometers where slip (up to 15 meters) concentrated on two main asperities situated on both sides of the epicenter. We found that rupture reached shallow depths, probably extending up to the trench. Resolvable afterslip occurred in regions of low coseismic slip. The low-frequency hypocenter is relocated 40 kilometers southwest of initial estimates. Rupture propagated bilaterally at about 3.1 kilometers per second, with possible but not fully resolved velocity variations.
ISSN: 0036-8075

hal-00783213
https://hal.archives-ouvertes.fr/hal-00783213
DOI : 10.1126/science.1204132

Éditeur(s) : HAL CCSD Federación Española de Asociaciones de Docentes de Educación Física (FEADEF)
Résumé : International audience
The scientific literature about AIDS and physical exercise has been traditionally dominated by biomedical approaches. The first studies which were published in the beginning of the nineties focused mainly on the transmission risks of the virus during sports. Later studies were concerned with the physiological logics of the exercise on HIV-positive persons. Since the end of the nineties the therapeutic progress contributed to envisage sport as a way to mediate the side effects of medical treatments. However the present review highlights a serious gap in the literature on Sport and HIV using a sociological point of view. The authors of this article argue that the time has come to consider sociological data linked to the experiences of HIV/AIDS in order to understand the difficulties and barriers that seropositive persons have to face when participating in sport.
ISSN: 1579-1726

hal-01681888
https://hal.archives-ouvertes.fr/hal-01681888

Éditeur(s) : Gauthier-Villars
Résumé : Analysis of Geosat sea level data over the period November 1986-November 1987 has evidenced long, low-frequency equatorial wave propagations over most of the equatorial Pacific basin (Delcroix et al.,1991). The succession of downwelling Kelvin, upwelling Kelvin, and upwelling Rossby waves has raised a series of questions. Is the observed upwelling Rossby wave due to a reflection process on the eastern boundary, or due to wind forcing near the equator? Why is there no evidence of a reflection of the downwelling Kelvin wave? Is this wave sequence a feature of the 1986-1987 El Nino phenomenon or is it to be found in the mean seasonal cycle? We used a linear model forced by the FSU wind stress to study these questions. The results, during the period November 1986-November 1987, show the successive downwelling/ upwelling Kelvin waves and upwelling Rossby wave as in the Geosat observations. Another test was made, using only the part of the forcing responsible for creating Kelvin waves, in order to evaluate the portion of the signals that was due to the reflection process and the part due to local forcing. It appears that wind forcing favourable to upwelling in the eastern part of the equatorial basin is the main mechanism which both generates the upwelling Rossby wave and inhibits the reflection of the downwelling Kelvin wave. However, the reflection of the upwelling Kelvin wave contributes to the upwelling Rossby wave signal, and makes it visible all the way from the eastern to the western sides of the equatorial Pacific. Results of a climatological run show that the successive downwelling/upwelling Kelvin and Rossby wave propagations are present in the mean seasonal cycle. However, the corresponding model signals, as well as the wind forcing anomalies, show a larger amplitude in 1986-1987.
Oceanologica Acta (0399-1784) (Gauthier-Villars), 1992 , Vol. 15 , N. 5 , P. 545-554

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00101/21180/18797.pdf
http://archimer.ifremer.fr/doc/00101/21180/

Éditeur(s) : HAL CCSD
Résumé : Patagonia is well known for spectacular occurrences of a variety of glacial-derived landforms and deposits and for a long history of ancient glaciations. In this paper, we first review the diverse evidence that demonstrates the development of glacial-related sedimentary units within the Central Patagonian Cordillera since 7 Ma. Well preserved glacial landforrns at the top surface of mesetas on both sides of the Lago General Carrera-Buenos Aires are described: the Meseta Guenguel to the north, and the volcanic Meseta del Lago Buenos Aires to the south. The latter meseta corresponds to a 3 Ma old, morphologically inverted paleo-piedmont, based on Ar/Ar dates of the uppermost lava flows. It shows evidence of glacier advances to the NE direction. Over a distance of 20 km, glacial landforms observed by remote sensing data and digital elevation model define glacial tongues that were fed by the Cordillera reliefs to the west. These lobes are now beheaded from their westward sources along a morpho-structural corridor that bounds the Meseta del Lago Buenos Aires to the west. These remnants can be correlated with the oldest glacial landforms recognized north of Lago General Carrera-Buenos Aires, on the Meseta Guenguel that form the Chipanque moraine system. From these features it is concluded that the glacial drainage network of Central Patagonia has been strongly modified following relief inversion in response to erosion processes and to tectonic causes. Changes occurred after 3 Ma, from a smooth piedmont surface covered by an extensive ice mantle ending with ample glacial lobes, to the current series of deeply incised glacial valleys such as the Lago General Carrera-Buenos Aires depression. These new data bear important constraints on the history and development of the first glaciations in southern South America.
ANDEAN GEOLOGY

hal-00512682
https://hal.archives-ouvertes.fr/hal-00512682

Résumé : Le fluide chaud produit par les forages de la centrale géothermique de Bouillante (Guadeloupe) est enrichi en espèces dissoutes telles que la silice qui peuvent précipiter sous forme de dépôts solides lors de son refroidissement et gêner fortement la production électrique. L’un des principaux objectifs de ce travail de thèse a donc été d’améliorer l’état des connaissances sur les conditions physiques, chimiques et cinétiques de la précipitation de la silice amorphe à Bouillante. Après une étude des caractéristiques physico-chimiques des fluides et des dépôts associés au champ de Bouillante, des expériences sur la cinétique de précipitation de la silice, sur site, pour une large gamme de température (25 - 90°C) et de pH (4 - 12) ont été menées et analysées en détail.Pour l’ensemble de ces expériences, seule la polymérisation (réversible) de la silice dissoute, sous forme de suspensions colloïdales très stables en solution, a été observée. La modélisation des données expérimentales de cinétique montre que la vitesse de polymérisation de la silice suit une loi d’ordre 2 vis-à-vis de la silice dissoute jusqu’à l’équilibre en accord avec une dimérisation de la silice. Par contre, durant l’étape initiale de la réaction, une loi d’ordre 4 semble mieux adaptée, suggérant des réactions de polymérisation plus complexes avec formation de tétramères. La température a un effet limité sur la cinétique de polymérisation de la silice comparé à l’effet du pH qui est beaucoup plus important. L’énergie d’activation de la réaction globale est de 41 - 54 kJ pour des pH compris entre 5 et 8.La caractérisation de la silice précipitée a mis en évidence des différences notables entre la structure poreuse de la silice solide prélevée sur les installations de surface et celle de la silice colloïdale obtenue par polymérisation lors des expériences de cinétique, ce qui semble indiquer que des mécanismes différents interviennent dans ces deux contextes de précipitation de la silice dissoute.Le deuxième objectif de cette thèse était d’évaluer la possibilité de valoriser la silice extraite de l’eau géothermale de Bouillante dans un procédé de traitement des eaux naturelles par adsorption. Pour cela, les propriétés d’adsorption de la silice géothermale brute et fonctionnalisée par le poly(ethylèneimine) (ou PEI) ont été étudiées pour deux polluants : un colorant, le bleu de méthylène et un métal lourd, le plomb. Les résultats obtenus montrent que la silice brute possède une grande capacité d’adsorption vis-à-vis du bleu de méthylène. En outre, la fonctionnalisation de la silice par le PEI permet d’améliorer sa capacité d’adsorption vis-à-vis du plomb en solution, en accord avec un modèle cinétique du pseudo-second ordre suggérant une chimisorption. Le modèle d’isotherme de Redlich-Peterson est également en très bon accord avec les données expérimentales.
The hot geothermal fluid produced by the geothermal power plant of Bouillante (Guadeloupe) contains various dissolved components such as silica that can precipitate as solid deposits during their cooling and cause serious problems on the electricity generation. One of the aim of this study is to improve the understanding on the physical, chemical and kinetics conditions of the amorphous silica precipitation in the Bouillante geothermal field. After a study on the physical and chemical characteristics of the Bouillante fluids and deposits which can form during their exploitation, experiments on the kinetics of silica precipitation, on site, under a large range of temperature (25 – 90°C) and pH (4 – 12) have been carried out and analyzed in detail.During on site kinetics experimentations only dissolved silica polymerization (reversible) as colloidal gel, very stable in solution, was observed. Modeling of the experimental data showed that the kinetics polymerization is characterized by a 2-order kinetic law relative to dissolved silica until the equilibrium that is consistent with silica dimerization. On the other side, the initial stage of the reaction is better characterized by a 4-order kinetic law that suggested more complex polymerization reactions with tetramers formation.Temperature has a little effect on the polymerization kinetics compared with the pH which has an effect more important. The activation energy of silica precipitation calculated between 25 and 90°C, is about 41 - 54 kJ for pH ranging to 5 - 8.The characterization of the silica precipitate reveals significant differences in the porous structure of the silica collected on the surface installations and the one obtained from kinetic experiments that suggests different precipitation mechanisms. The second objective of this thesis was to evaluate the possibility to promote geothermal silica for the treatment of natural waters containing contaminants by adsorption. Adsorption properties of the untreated and functionalized by poly(ethylèneimine) (ou PEI) geothermal silica have been investigated for two pollutants: a colorant, the methylene blue and a heavy metal, the lead.Results showed that untreated silica has a great adsorption capacity concerning the methylene blue. Besides, silica functionalization by the PEI allows improving the adsorption capacity for lead in solution. The adsorption kinetics curves followed a pseudo-second order model consistent with a chimisorption. The isotherm model of Redlich-Peterson fitted well the experimental data.

http://www.theses.fr/2014AGUY0698/document

Éditeur(s) : HAL CCSD Geological Society of America
Résumé : International audience
The post-rift denudation history of high-elevation divergent continentalmargins is central to deciphering source-to-sink systems acrosssuch margins and to unraveling their topographic evolution. We performed40Ar-39Ar dating of supergene K-Mn oxides from supergenemanganese ore deposits in order to constrain the age of in situ formedlaterites on both the lowland and highland sides of the Western GhatsEscarpment of Peninsular India. Documentation of laterites as oldas 53 Ma on the highland and 47 Ma at the foot of the escarpmentshows that the escarpment stabilized before 47 Ma (possibly 60 Ma).The topographic setting of the dated weathering mantles also constrainsdenudation of the lowland and the highland since ca. 50 Mato maximums of 5 m/m.y. and 15 m/m.y., respectively. Our resultschallenge denudation rates derived from apatite fission track thermochronologyby documenting the topography and relief longevityof the southwest Indian margin and its hinterland. The results precludelarge-magnitude uplift of Peninsular India after the Eocene,and more generally argue against late Neogene uplift and topographicrejuvenation of continental shields.
ISSN: 0091-7613

ird-01419633
http://hal.ird.fr/ird-01419633
http://hal.ird.fr/ird-01419633/document
http://hal.ird.fr/ird-01419633/file/GEOLOGY-S-15-00851_HAL.pdf
DOI : 10.1130/G37303.1

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
In Taiwan, about one third of the lithospheric plate convergence between Eurasia and the Philippine Sea plate is accommodated on the eastern coast across the narrow Longitudinal Valley (LV). The Longitudinal Valley Fault (LVF) is the main seismically active fault zone in this region. However, the spatial distribution of ground deformation due to interseismic loading on locked fault segments remains widely unknown. To address this problem, we use a "permanent scatterer" (PS) interferometric synthetic aperture radar (InSAR) approach for processing the ERS satellite archives. The PS mean velocity maps allow accurately mapping and quantifying the ground deformation all along the LV. Assuming that, close to the surface, the fault plane along the central LVF creeping segment dips 55 degrees to the east, we derive a slip vector at the surface of similar to 25 mm/yr with a mean rake of 70 degrees. In agreement with our PS observations, shallow seismicity indicates a clear change in the fault mechanical behavior of the creeping segment around Fuli town. Finally, we propose a combination of the PS velocity fields for estimating a 3-D map of ground deformation. In the southern part of the LV, the vertical component reveals an uplift of the Coastal Range with respect to the LV of similar to 10 mm/yr. Moreover, between Taitung and Luyeh, the vertical deformation is essentially accommodated along the Luyeh Strand. Finally, north of Rueisuei, the Coastal Range uniformly subsides at similar to 15 mm/yr relative to the western side of the LV. However, a local uplift pattern is detected around latitude 23 degrees 42'.
ISSN: 0148-0227

hal-00595532
https://hal.archives-ouvertes.fr/hal-00595532
DOI : 10.1029/2010JB007898