Résumé : From the PNCR, GAP MPs free to vote conscience on gay rights bill By Johann Earle Stabroek News June 11, 2003 The PNCR will allow its members to vote their conscience on the controversial Constitution (Amendment) Act of 2001 which seeks to prevent discrimination against persons on the basis of their sexual orientation and other grounds. A number of religious organisations are opposed to the passage of the bill because it includes sexual orientation as one of the grounds. They are concerned that it could lead to a legalisation of homosexual relations and demands for recognition of gay marriages among other things. PNCR Member of Parliament (MP) Vincent Alexander told a forum at the National Library on Saturday, that the Bill did not seek to legalise homosexuality, but to ensure that persons would not be discriminated against based on their sexual preferences. He was one of two parliamentarians who showed up - the other being PNCR member, Myrna Peterkin. The forum was organised by Students Against Sexual Orientation Discrimination (SASOD), a group comprising fifteen students from the University of Guyana which was formed about two weeks ago. Alexander expects the vote on the bill to come up before the National Assembly in a matter of months. Paul Hardy, Leader of the Guyana Action Party (GAP), told Stabroek News that his party would not be using the so-called parliamentary whip. He added that GAP took a decision that every member should vote according to his or her own conscience. “We have no right to deny the rights of others based on sexual orientation. [The Bill] will guarantee rights to the homosexual.” GAP is in Parliament as part of an alliance with the Working People’s Alliance. GAP/WPA has two MPs. The bill was met with rejection from some members of the religious community in 2001 and as a result of this, the President did not assent to it. In a statement on Monday, the Central Islamic Organisa-tion of Guyana (CIOG) said that it stood in firm opposition to the Bill. The CIOG says the general purpose of the bill may be commendable and that the organisation’s objection is not based on a willingness to promote discrimination. Rather, the CIOG said, it was based on the fact that specific legal protection on the basis of sexual orientation without definition or qualification gives tacit legitimacy to practices which are considered criminal in Islam. “It is foreseeable that such a legal nod of approval (subtle as it may be) of these practices may pave the way for greater social (or even legal) acceptability in the future which, from the perspective of all Muslims including those in Guyana, is an undesirable and sinful outcome,” the CIOG statement said. At Saturday’s event, Muslim teacher Moulana Mohamed Ali Zenjibari spoke of instances of abuse, discrimination and harsh penalties meted out to gay and lesbian persons in countries such as Iran and Saudi Arabia and noted that the Quran did not sanction such punishments for homosexual behaviour. President of the CIOG, Fazeel Ferouz told Stabroek News that a meeting to discuss a strategy with regards to the bill was planned for tomorrow with various religious groups. Stabroek News tried to get a comment on the issue from the PPP/C but to no avail. ROAR leader, Ravi Dev said that his party was now having discussions on the issue. ROAR feels that it is an important question which has to do with morality and should be discussed across the country. He added legislators had to be in tune with their constituents on the issue. SASOD is lobbying for the legislation through the sensitisation of MPs. Keimo Benjamin, a law student at UG, gave a presentation based on the jurisprudential aspects of the discussion on sexual orientation. He argued that morality should not be the only guiding principle on which to base the laws. Sexual activities between two consenting male adults in private could not be equated with a violation of a person’s rights, he said, making the point that the thrust of his presentation was not whether homosexuality was wrong, but whether it violated the rights of others. He said that the attitudes of some towards this subject were based on preconceived notions and prejudices. He cited studies to show that the suppression of certain perceived deviant sexual impulses in persons might do more harm than good. One Harvard University study of teens who said they were gay indicated that those teens were three times more likely to commit suicide. Vidyaratha Kissoon, of Help and Shelter, in his contribution on Saturday, expressed his displeasure at the low turnout at the forum and urged the parliamentarians who showed up to take the message to their colleagues. He noted that because of homophobia, the numerical minority was terrified of speaking out against instances of discrimination. Gays and lesbians in Guyana were subjected to ridicule and abuse, and walk the streets at night not looking for sex necessarily, but for the companionship of persons who empathise with them. During his presentation, Joel Simpson, another member of SASOD, outlined a number of changes made within national jurisdictions that had international implications. One such crucial change was South Africa’s 1996 adoption of a new constitution, making that country the first in the world to expressly include sexual orientation as a prohibited ground of discrimination. It was the first time a developing country had taken the lead with respect to the rights of sexual minorities. He also said that according to Douglas Sanders, a Canadian jurist, the rights of homosexual, bisexual or transsexual men and women had never been officially recognised by the United Nations, despite the fact that international laws on the issue began to emerge at the close of the Second World War. Simpson said that under Article 170 (5), as amended by Section 8 of the Constitution (Amendment) (No. 4) Act 2000, the President is required to assent to any bill which is returned by the National Assembly unaltered after a two-thirds majority within 90 days of its presentation to him. To the parliamentarians present, Simpson stressed that the onus was now on them to adequately represent their constituents which include lesbian, gay, bisexual and transsexual Guyanese. http://www.landofsixpeoples.com/news301/ns306115.htm and Vote on sexual orientation should be a matter of conscience - MP Alexander By Esther Elijah Guyana Chronicle June 8, 2003 PEOPLE’S National Congress (PNC/R) Member of Parliament Mr. Vincent Alexander, said the Opposition will vote on “conscience” when the piece of legislation on sexual orientation is again brought before the National Assembly. “With specific reference to my party, when this Bill gets back to the Parliament in the spirit of the arguments here, we will not use the `whip’. Our party will not say we have to vote for the provision (in the Sexual Orientation Bill). We will allow our members to vote as a matter of conscience,” he told participants gathered in the Conference Room of the National Library. “We feel this is a matter of conscience. You may end up with a collective position but you have to deal with us individually,” Alexander said at a poorly attended public consultation aimed at gaining support for sexual orientation to be considered a fundamental right in Guyana. Alexander, one of the main persons who sat on the Constitutional Reform Commission that addressed this controversial clause, said the legislation was not meant to legalise homosexual activities in Guyana. “It was intended to ensure that persons who have an orientation - a way of thinking - which may or may not lead to a certain activity, to not be discriminated against, in terms of their rights,” he explained. Alexander noted that very often, discussions on the sexual orientation provision in the Bill have led to seepages into other areas where debates centre on the “right to be homosexual.” “I am saying the Bill does not comment on that… However, law is peculiar, especially in a Common Law system. Once you venture out and change the law, very often you open other windows which we cannot definitively say exist or does not exist in advance,” he said. “The fear of some people is that the legislators might say one thing and the Courts will eventually say something else. While some people can’t argue against the law, per say, they will say this has opened a window of opportunity not meant to be opened. So, it is better to stay without a window than open it and then have a possibility of something you didn’t intend to happen - happening sometime in the future.” Alexander added: “I want to say I’ve found this activity to have been rich from the perspective of the amount of research which was done by student (speakers). Without any comment as to whether I agree with the arguments, I would wish that much more research on other issues be done by students, and that at the University (of Guyana) students would find it convenient to have forums on other issues, with the same depth of research for their own intellectual development.” Alexander and other Opposition M.P, Lurlene Nestor were the only three Parliamentarians in attendance at the session organised by the recently formed `Students Against Sexual Orientation Discrimination’ (SASOD), a group that has a membership of 15 mostly University of Guyana (UG) students from various faculties. SASOD was established two weeks ago. With the exception of members of the press, the consultation only managed to attract 11 persons, a handful of who were SASOD members. While congratulating the students for an “insightful” presentation, Nestor pointed out that whether or not she chooses to agree with their position is “another issue” and she is entitled to her “own view”. “The issue of sexual orientation is very `toucheous’ …while we agree with the human rights provisions and all that as a society, we must also revert to our own society. Some of the very critical questions that I would want to ask is whether or not at the society (level) we are ready for that kind of thing,” she remarked. “We cannot, at (any) time, ignore the religious groups in our society. If we look at statistics going back to 1992 from a survey done by the Bureau of Statistics, we would see that a small section of the Guyanese population might be considered as people who do not subscribe to a religious view. While the laws are not necessarily based on moral values, we must acknowledge the fact that we might want to revert to many of the cases that (concern) laws that protect public morality.” Nestor told the speakers at the consultation these were some of the issues that they needed to deal with. She highlighted, too, that what must be examined is the effects of same-sex marriages on society and how this issue must be tackled. “These are some of the things we should consider and I don’t think you dealt with that in the presentations,” Nestor stated, adding that the issues must be addressed “frontally.” “Do we think that with the coming to being of this Bill that there might be quite a number of challenges to the Constitution in relation to the same issue of a man marrying a man? What do we do at the society (level)? Do we recognise that?” were the questions directed at the five speakers at the session. Nestor continued: “There is some argument that says, `Oh the Bill does not promote homosexuality or does not encourage a man to marry (another) man, but if you look at Section (15) that talks about `non-discrimination’ then how can we not, with the passage of this Bill, allow a man not to marry (another) man.” According to Nestor, matters of this nature constitute some of the “inconsistencies” of the Bill. On the argument raised by presenters at the session on who determines what is morality, Nestor said in the concept of democracy it is the people who are the determinants based on a “line of thinking.” She also rebutted on grounds that put the spotlight on teachers who may have been caught “interfering” with their young students and who may subsequently be dismissed from their jobs. “Could you imagine such a person interfering with a boy below age 10 - and by virtue of the fact that the Bill is there, the judges (in the case) will have to use their discretion in terms of what happens. We will have more Constitutional changes and problems (arising with the passage of the Bill).” SASOD member and law student, Joel Simpson, in reply, said he doesn’t think any homosexual in Guyana wants to “run into a church and ask that people marry them or anything of that sort.” At one point likening the church to a “club”, Simpson claimed the church has the right to exclude whomever it wants. He further stated that in accordance with the Constitution, people of the same sex do not currently have the right to marry, and will also not be able to do such an act with the passage of the Bill. However, Simpson said it is possible that the law, with the passage of the Bill, would have to recognise same-sex domestic partnerships in relation to employment benefits, sharing of properties, etc. Simpson said he believes there should be a realm of “public” and “private” morality between consenting adults, and implied that the Bill did not fully give “rights” to homosexuals. But, Nestor interjected: “I am informing you further…that the Sexual Orientation provision has, in fact, in some way recognised the rights of homosexuals and we must accept that.” Meanwhile, there was no vocal Christian representative(s) at the consultation and apart from the two Opposition representatives none other participant gave comments or directed questions at the presenters. Other speakers in support of the sexual orientation clause were: Moulana Mohammed Ali Zenjiban, Assistant Director of the International Islamic College; Denuka Radzik from Red Thread, Keimo Benjamin, UG law student and Vidyartha Kissoon from Help & Shelter. The Sunday Chronicle has been reliably informed that the Georgetown Ministers Fellowship, representing groups of Christian leaders staunchly against sexual orientation as a right in Guyana, have recently prepared a detailed 16-page document outlining issues arising from research to further boost their argument against the inclusion of the clause. The document is yet to be made public. http://www.landofsixpeoples.com/news301/nc306083.htm

Droits : All rights reserved by the source institution.
http://ufdc.ufl.edu/AA00014700/00001

Éditeur(s) : HAL CCSD Impact journals
Résumé : International audience
Targeted therapies have substantially changed the management of non-small cell lung cancer (NSCLC) patients with driver oncogenes. Given the high frequency, EGFR and ALK aberrations were the first to be detected and paved the way for tyrosine kinase inhibitor (TKI) treatments. Other kinases such as ROS1 and more recently RET have emerged as promising targets, and ROS1 and RET TKIs are already available for precision medicine. We screened a large cohort of 713 Caucasian non-squamous NSCLC patients lacking EGFR/KRAS/BRAF/HER2/PI3KCA/ALK aberrations for ROS1 and RET rearrangements using fluorescence in situ hybridization to determine the frequency and clinicopathological characteristics of ROS1- and RET-positive patients. Frequencies of ROS1 and RET rearrangements were 2.1% and 2.52%, respectively. Contrary to common belief, both ROS1 and RET rearrangements were detected in patients with a history of smoking, and the RET-positive patients were not younger than the negative patients. Moreover, RET but not ROS1 rearrangement was associated with the female gender. Nearly half of the ROS1-rearranged patients were successfully treated with ROS1 TKIs. In contrast, only 5/18 RET-positive patients received off-label RET TKIs. Two patients had stable disease, and three experienced disease progression. In addition to the 18 RET-positive cases, 10 showed isolated 5' signals. The clinical relevance is unknown but if the frequency is confirmed by other groups, the question whether these patients are eligible to TKIs will arise. More potent RET TKIs are under development and may improve the response rate in RET-positive patients. Therefore, we recommend the routine implementation of RET testing in non-squamous NSCLC patients, including those with a history of smoking.
ISSN: 1949-2553

hal-01578586
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578586
DOI : 10.18632/oncotarget.18408
PUBMED : 28881815

Résumé : The boundaries of territorial waters are not as stable as boundaries on land. Nowadays, indeed they are characterised by their very mobility. No doubt the reason for this is political. A state which sought to further her own interests by enlarging her domain within her own waters would encounter no sovereign opposition. Additonally, with the collapse of the traditional "understanding" regarding the conception of -and the criteria governing -maritime boundaries. nations chose the most effective methods of appeasing their own needs and appetites. This was achieved with the maximum ingenuity. The natural boundary myth was shaken sometimes before and sometimes simultaneously with, the cultivation of negotiating skills or, from a position of strength. the imposition of "political limits". Fruitful sources of approximation were provided by phenomena such as low-water mark, the continental shelf. the Humboldt current and so on. As for accuracy. however. this was obtained by the application of geometrical methods such as calculation on a straight line basis or by equidistance or. again. by numeric evaluation : expression of distance in nautical miles. The general effect of this medley of arguments - or pretexts - has been to add to the fluctuating nature of sea boundaries rather than contribute to their stability. In fact. the only way stabilisation of these boundaries is usually achieved is by confrontation between two or more adjacent and competing sovereign states once the question of demarcation has been hammered out. The ocean, "man's common heritage", seems to have entered a phase of parcelling out, of sharing. [NOT CONTROLLED OCR]
Les frontières maritimes n'ont pas la stabilité des frontières terrestres. Dans la présente époque, au contraire, elles se caractérisent essentiellement par leur mobilité. La principale raison de ce phénomène est sans doute d'ordre politique : au large de sa mer territoriale, l'État ne rencontre pas d'autre souveraineté lorsque ses intérêts le portent à étendre son emprise. Aussi, lorsque le « consensus » international traditionnel sur la conception et le critère de la frontière maritime fut ruiné. les États laissèrent libre cours à leur ingéniosité pour choisir les techniques les plus adéquates à la pleine satisfaction de leurs besoins et de leurs appétits. Tour à tour, et, parfois. simultanément. fut agité le mythe de la « frontière naturelle » et cultivé l'art de négocier ou d'imposer, selon les rapports de force. des "limites politiques". La "laisse de basse mer", la "marge continentale ", le courant de Humboldt. etc. fournirent des approximations fécondes. Mais la certitude est venue des techniques géométriques (lignes de base droites, équidistance) ou des évaluations chiffrées (distance exprimée en milles marins). De façon générale. ces divers arguments, ou prétextes. ont puissamment alimenté le dynamisme des frontières maritimes et fort peu contribué à leur stabilisation. Celle-ci ne procède finalement que de la rencontre de deux ou plusieurs souverainetés voisines et concurrentes. une fois tranchées les querelles de "bornage". L'océan, "héritage commun de l'humanité", est entré, semble-t-il, dans une phase de liquidation et de partage... [OCR NON CONTRÔLE]

Droits : 1979 CNEXO
http://archimer.ifremer.fr/doc/1979/rapport-4798.PDF
http://archimer.ifremer.fr/doc/00000/4798/

Éditeur(s) : HAL CCSD Geological Society of America
Résumé : If the net flux to the island arc crust is primitive arc basalt, the evolved composition of most arc magmas entails the formation of complementary thick ultramafic keels at the root of the island arc crust. Dunite, wehrlite, and Cr-rich pyroxenite from the Jijal complex, constituting the Moho transition zone of the Kohistan paleo–island arc (northern Pakistan), are often mentioned as an example of high-pressure cumulates formed by intracrustal fractionation of mantle-derived melts, which were later extracted to form the overlying mafic crust. Here we show that calculated liquids for Jijal pyroxenites-wehrlites are strongly rare earth element (REE) depleted and display flat or convex-upward REE patterns. These patterns are typical of boninites and are therefore unlike those of the overlying mafic crust that have higher REE concentrations and are derived from light rare earth element (LREE)–enriched melts similar to island arc basalt. This observation, along with the lower 208Pb/204Pb and 206Pb/204Pb ratios of Jijal pyroxenites-wehrlites relative to gabbros, rejects the hypothesis that gabbros and ultramafic rocks derive from a common melt via crystal fractionation. In the 208Pb/204Pb versus 206Pb/204Pb diagram, ultramafic rocks and gabbros lie on the same positive correlation, suggesting that their sources share a common enriched mantle 2 (EM2) signature but with a major depleted component contribution for the ultramafic rocks. These data are consistent with a scenario whereby the Jijal ultramafic section represents a Moho transition zone formed via melt-rock reaction between subarc mantle and incoming melt isotopically akin to Jijal gabbroic rocks. The lack in the Kohistan arc of cogenetic ultramafic cumulates complementary to the evolved mafic plutonic rocks implies either (1) that a substantial volume of such ultramafic cumulates was delaminated or torn out by subcrustal mantle flow from the base of the arc crust in extraordinarily short time scales (0.10–0.35 cm/yr), or (2) that the net flux to the Kohistan arc crust was more evolved than primitive arc basalt.
ISSN: 0091-7613

hal-00406688
https://hal.archives-ouvertes.fr/hal-00406688
DOI : 10.1130/G23675A.1

Résumé : After a period of rapid development of the sites (an increase in both reared surface area and production), tropical shrimp aquaculture is currently being faced with critical problems due to economical and ecological constraints. In many countries with favourable conditions for shrimp aquaculture such as indonesia or Vietnam, sites are often badly selected and/or over-exploited. This conducts to sorne extent to decreases or collapses in the production due to the difficulty in predicting the maximum production capacity of the sites. Furthermore, it appears that production sustainability depends on many factors among which socio-economy and ecolo gy are of prime importance. The STD3 project titled « Assessment of tropical shrimp aquaculture impact on the environment in tropical countries using hydrobiology, ecology and remote sensing as helping tools for diagnosis )) was initiated in 1994, with the aim to study the sustainability of marine shrimp aquaculture in tropical areas, main! y Indonesia and Vietnam, through the following tasks: (i) improve site selection and study the impact of aquaculture on marine environments presenting a variable sensitivity to organic sewage, (ii) analyse the socio-economical aspects and profitability of the aquaculture industry and of common resources (iii) use remote sensing and geographical data bases for diagnosis and monitoring of site degradation (iv) reinforce the capacity of Asian scientists through training. Severa! aquaculture sites have been investigated in the Lampung region (South Sumatra, Indonesia), the Mekong delta (Vietnam) and on the West coast of New-Caledonia, providing a large range of typical ecosystems encountered in Asia and in the Pacifie, from coralline sites to coastal plains with mangrove and deltaic areas. The study concerned the spatial structure and seasonal influence of these ecosystems, the temporal variation during the course of the project (3 years) and the relation between the ecological structure and farm productions. Remote sensing provides a synoptic vision over large land expanses. Severa! scenes were processed for landuse mapping using conventional classification techniques. Concerning water quality assessment, a general relation for the Java sea was found between image and field data in terms of total suspended matter. Applying this relation to a new site in Sumatra has provided an initial approach to water type and, together with land use mapping, a preliminary assessment of the suitability of the area to shrimp aquaculture development. Socio-economic research has been focused on the identification ofneeds for collective action, including public policy, in the perspective of shrimp farming sustainability. The main concern is in the regulation of shrimp farming intensification and extensification at the scale of coastal ecosystemic entities in a common property resource management perspective. The common considered here is coastal water quality. Comparing the local development profiles and the institutional grounds for the design and implementation of collective management rules shows that variables such as land tenure system, farm owner socio-economic profile, social homogeneity or heterogeneity of the farmers are key factors to analyse the potential for sustainability. The defmition of water quality and the possible means to ensure its collective management are discussed. The main conclusion is that the economie incentives to farming development are strong but there is no significant difference among traditional, semi-intensive and intensive systems in terms of economie efficiency or wealth distribution. The description of the functioning of the different kinds of ecosystems make it possible to give an advice concerning the positioning of the activity inside the ecosystem, and furthermore to have a reference state in order to determine the impact of the activity on the coastal environnement. This impact can be summarized as an increase in the concentration of total suspended matt€?r, of particulate organic matter and of sulfate reducing bacterias. This organic ma~.er is either issued from rearing activities or from telluric origine, due to mangrove eradication when building the ponds. An evaluation of the relationship existing between productivity and characteristics of each ecosystem bas been conducted by correlating ecological indicators data (concentration of total suspended matter, particulate organic matter, chlorophyll, percentage of pheopigments in total pigments and cyanobacteria and sulfatereducing bacteria in water and sediments) with the average production of the farms. This comparison lead to the compilation of a scale of observed production integrating the range of these environmental parameters with shrimp production levels, bound to facilitate the positioning of shrimp farming in relation with the confmement leve! of each ecosystem. Lastly, ali geographie data originated from the various compartments of the study have been geo-referenced and loaded into a geographical information system. This allows to display any query made on spatial variables and their related statistical data, including the ir variations over the last few years and to reveal patterns and phenomena otherwise not obvious.
Le programme mis en oeuvre par la DRV (Paris, CREMA-L'Houmeau, DELIAO Brest, COP Tahiti, GIE/RA Nouvelle Calédonie), dans le cadre d'un projet européen STD3 «(Sciences et Technique au Service du Développement», en collaboration avec l'Université de Montpellier II, l'Ecole Nationale d'Agronomie de Rennes, l'ITC (Hollande), l'Institut Océanographique de Nha Trang (Vietnam), le BADC de Jepara et le BPPT de Jakarta (Indonésie), avait pour but la mise au point de méthodes permettant d'améliorer la sélection des sites ainsi que le suivi du développement et de l'impact de l'aquaculture des crevettes Péneides en milieu tropical pour éviter la surexploitation. Quatre axes de recherche ont été défmis : a) identifier la nature et quantifier les rejets de déchets issus de ce type d'aquaculture, b) définir les caractéristiques écologiques des écosystèmes susceptibles d'accueillir l'activité aquacole et suivre leur évolution sous l'influence des rejets, c) déterminer l'influence de la gestion des fermes et des ressources (aspects économiques) sur les performances de productivité, d) déterminer la capacité de la télédétection comme outil de diagnostic d'impact à l'échelle de la région, e) mener un programme de formation d'étudiants et jeunes chercheurs Vietnamiens et Indonésiens.

Droits : 1998 Ifremer
http://archimer.ifremer.fr/doc/00132/24357/22357.pdf
http://archimer.ifremer.fr/doc/00132/24357/

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Motivation: Gene fusion is an important evolutionary process. It can yield valuable information to infer the interactions and functions of proteins. Fused genes have been identified as non-transitive patterns of similarity in triplets of genes. To be computationally tractable, this approach usually imposes an a priori distinction between a dataset in which fused genes are searched for, and a dataset that may have provided genetic material for fusion. This reduces the `genetic space' in which fusion can be discovered, as only a subset of triplets of genes is investigated. Moreover, this approach may have a high-false-positive rate, and it does not identify gene families descending from a common fusion event. Results: We represent similarities between sequences as a network. This leads to an efficient formulation of previous methods of fused gene identification, which we implemented in the Python program FusedTriplets. Furthermore, we propose a new characterization of families of fused genes, as clique minimal separators of the sequence similarity network. This well-studied graph topology provides a robust and fast method of detection, well suited for automatic analyses of big datasets. We implemented this method in the C++ program MosaicFinder, which additionally uses local alignments to discard false-positive candidates and indicates potential fusion points. The grouping into families will help distinguish sequencing or prediction errors from real biological fusions, and it will yield additional insight into the function and history of fused genes.
ISSN: 1367-4803

hal-01544795
https://hal.archives-ouvertes.fr/hal-01544795
DOI : 10.1093/bioinformatics/btt049

Éditeur(s) : Actes du 6e colloque national BRG, La Rochelle, 2-3-4 octobre 2006
Résumé : Previous studies have shown heritable variation in larval developmental traits in the Pacific oyster Crassostrea gigas. In order to study the genetic consequences of production of oyster larvae in hatcheries, two factors, specific to hatcheries, were examined: the effect of discarding the smallest larvae (i.e. culling) and the effect of temperature (20°C versus 26°C). A mixed-family approach was used in order to infer the genetic composition of larval populations and family assignment, limiting possible environmental bias and allowing the study of a relatively large number of families using a limited number of larval tanks. Our results show that three multiplexed highly polymorphic microsatellite markers are a powerful tool for family assignment and, consequently, for the study of bivalve larvae genetics. Culling, by selective sieving of the smallest larvae is an advantageous practice at a phenotypic scale as it reduced variance in larval size, variance of developmental rate and time to settlement. Culling of 50% of the larval population only led to 15% less spat, showing a positive phenotypic correlation between larval growth and settlement success. However, culling represents a substantial risk for diversity loss, because it increases the variance of reproductive success among parental oysters. The effective population sizes of early settling cohorts of settlement were lower than those of later ones. Our results show that the settlement of slow growing larvae significantly contributes to minimizing the variability of reproductive success and therefore to maximizing genetic diversity. These results corroborate the low estimations of variability of broodstocks sampled in several French commercial hatcheries, relative to natural populations. The genetic composition of the larval population and the resulting spat was significantly different between the two tested temperatures, revealing genotype x environment interaction for survival. Similarly, genotype x environment interaction was also observed for larval growth as a higher temperature exerted a positive influence on the expression of genetic variability for this trait. Consequently, we can conclude that a temperature of 26°C coupled with culling, to common practice in oyster hatcheries, is likely to amplify the selection pressure for fast growing larvae. To test for this hypothesis, we compared larval developmental traits in the progeny of a hatchery broodstock closed for 7 generations, with the progeny of wild oysters and the two possible hybrids. Our results show that selection of fast growing larvae can counteract presumed inbreeding depression, due to higher mean relatedness among hatchery broodstock than in the wild. Genetic effects of intensive rearing conditions at larval stage are significant and should be taken into account in hatchery practices, especially in terms of genetic diversity management.
Afin d'étudier les conséquences génétiques des pratiques de production en écloserie d'huître creuse, deux facteurs ont été examinés : l'élimination des petites larves et la température. Nos résultats montrent que l'assignation de parenté par marqueurs microsatellites est un outil performant pour les études génétiques en phase larvaire de familles élevées en mélange. Bien qu'avantageux d'un point de vue phénotypique, le tamisage sélectif représente un risque de perte de diversité. La fixation des larves à croissance lente permet en effet de minimiser la variabilité du succès reproducteur et de fait, de maximiser la variabilité génétique. Ces résultats corroborent les estimations de variabilité sur les stocks d'écloseries françaises où l'on constate une diversité allélique inférieure à celle de populations issues du milieu naturel. La température exerce également une influence sur la précocité de l'expression de la variabilité génétique pour la croissance larvaire. Ainsi une température élevée associée à une procédure de tamisage peut amplifier l'effet sélectif. Enfin, la sélection de larves à croissance rapide semble démontrée, s'opposant à la dépression de consanguinité présumée. Les conditions d'élevage peuvent donc avoir un effet génétique significatif qui devrait être pris en considération dans les pratiques d'écloserie, notamment dans la gestion de la diversité génétique.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2006/acte-1505.pdf
http://archimer.ifremer.fr/doc/00000/1505/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The non-classical human leukocyte antigen-G, HLA-G, plays an important role in inducing tolerance, through its immunosuppressive effects on all types of immune cells. Immune tolerance is a key issue in the liver, both in liver homeostasis and in the response to liver injury or cancer. It would therefore appear likely that HLA-G plays an important role in liver diseases. Indeed, this molecule was recently shown to be produced by mast cells in the livers of patients infected with hepatitis C virus (HCV). Furthermore, the number of HLA-G-positive mast cells was significantly associated with fibrosis progression. The generation of immune tolerance is a role common to both HLA-G, as a molecule, and the liver, as an organ. This review provides a summary of the evidence implicating HLA-G in liver diseases. In the normal liver, HLA-G transcripts can be detected, but there is no HLA-G protein. However, HLA-G protein is detectable in the liver tissues and/or plasma of patients suffering from hepatocellular carcinoma, hepatitis B or C, or visceral leishmaniasis and in liver transplant recipients. The cells responsible for producing HLA-G differ between diseases. HLA-G expression is probably induced by microenvironmental factors, such as cytokines. The expression of HLA-G receptors, such as ILT2, ILT4, and KIRD2L4, on liver cells has yet to be investigated, but these receptors have been detected on all types of immune cells, and such cells are present in liver. The tolerogenic properties of HLA-G explain its deleterious effects in cancers and its beneficial effects in transplantation. Given the key role of HLA-G in immune tolerance, new therapeutic agents targeting HLA-G could be tested for the treatment of these diseases in the future.
ISSN: 0168-8278

hal-01134468
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468/file/Biology%20of%20the%20immunomodulatory%20molecule%20HLA-G.pdf
DOI : 10.1016/j.jhep.2015.03.007

Éditeur(s) : HAL CCSD
Résumé : International audience
We present a new 3-D GPS velocity solution for 182 sites for the region encompassing the Western Alps, Pyrenees, and southern France. The velocity field is based on a Precise Point Positioning (PPP) solution, to which we apply a common-mode filter, defined by the 26 longest time series, in order to correct for network-wide biases (reference frame, unmodeled large-scale processes, etc.). We show that processing parameters, such as troposphere delay modeling, can lead to systematic velocity variations of 0.1–0.5 mm yr−1 affecting both accuracy and precision, especially for short (< 5 years) time series. A velocity convergence analysis shows that minimum time-series lengths of  ∼  3 and  ∼  5.5 years are required to reach a velocity stability of 0.5 mm yr−1 in the horizontal and vertical components, respectively. On average, horizontal residual velocities show a stability of  ∼  0.2 mm yr−1 in the Western Alps, Pyrenees, and southern France. The only significant horizontal strain rate signal is in the western Pyrenees with up to 4  ×  10−9 yr−1 NNE–SSW extension, whereas no significant strain rates are detected in the Western Alps (< 1  ×  10−9 yr−1). In contrast, we identify significant uplift rates up to 2 mm yr−1 in the Western Alps but not in the Pyrenees (0.1 ± 0.2 mm yr−1). A correlation between site elevations and fast uplift rates in the northern part of the Western Alps, in the region of the Würmian ice cap, suggests that part of this uplift is induced by postglacial rebound. The very slow uplift rates in the southern Western Alps and in the Pyrenees could be accounted for by erosion-induced rebound.
ISSN: 1869-9529

hal-01395116
https://hal.archives-ouvertes.fr/hal-01395116
https://hal.archives-ouvertes.fr/hal-01395116/document
https://hal.archives-ouvertes.fr/hal-01395116/file/nguyen2016.pdf
DOI : 10.5194/se-7-1349-2016

Éditeur(s) : HAL CCSD Elsevier
Résumé : High-precision Ni isotopic variations are reported for the metal phase of equilibrated and unequilibrated ordinary chondrites, carbonaceous chondrites, iron meteorites, mesosiderites, and pallasites. We also report new Zn and Cu isotopic data for some of these samples and combine them with literature Fe, Cu, and Zn isotope data to constrain the fractionation history of metals during nebular (vapor/solid) and planetary (metal/sulfide/silicate) phase changes. The observed variations of the Ni-62/Ni-58, Ni-61/Ni-58, and Ni-60/Ni-58 ratios vary linearly with mass difference and define isotope fractionation lines in common with terrestrial samples. This implies that Ni was derived from a single homogeneous reservoir. While no Ni-60 anomaly is detected within the analytical uncertainties, Ni isotopic fractionation up to 0.45 parts per thousand per mass-difference unit is observed. The isotope compositions of Ni and Zn in chondrites are positively correlated. We suggest that, in ordinary chondrites, exchange between solid phases, in particular metal and silicates, and vapor followed by mineral sorting during accretion are the main processes controlling these isotopic variations. The positive correlation between Ni and Zn isotope compositions contrasts with a negative correlation between Ni (and Zn) and Cu isotope compositions, which, when taken together, do not favor a simple kinetic interpretation. The observed transition element similarities between different groups of chondrites and iron meteorites are consistent with the genetic relationships inferred from oxygen isotopes (IIIA/pallasites and IVA/L chondrites). Copper is an exception, which we suggest may be related to separate processing of sulfides either in the vapor or during core formation. (C) 2007 Elsevier Ltd. All rights reserved.
ISSN: 0016-7037

hal-00408304
https://hal.archives-ouvertes.fr/hal-00408304
DOI : 10.1016/j.gca.2007.06.049

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Avril 2011. L’agitation dans les rues est le signe qu’un événement capital pour l’avenir du pays se prépare : Raoul Castro a convoqué la réunion du 6e congrès du Parti Communiste Cubain. Après des années de revendication d’un système social égalitaire échappant à la tutelle étasunienne, les structures économiques de la perle des Caraïbes sont remises en question. L’arrivée des printemps arabes, qui symbolisent la révolte des peuples vis-à-vis d’une gouvernance politique et économique autoritaire et rigide, n’est probablement pas étrangère à ce soudain besoin de modifier les structures économiques existantes à Cuba. Au menu, ce sont 291 mesures qui sont annoncées pour améliorer le quotidien des cubains, dont le salaire moyen mensuel est de 12 euros. Quant à la relation qu’entretient Cuba avec l’UE, elle revêt aujourd’hui une dimension surtout bilatérale : la position commune de 1996 n’a en effet jamais été modifiée, les Etats Membres adoptant une attitude différente selon les relations qu’ils entretiennent avec Cuba, tant d’un point de vue politique qu’historique.
April, 2011. The excitement in streets is the sign that a major event for the future of the country gets ready: Raoul Castro convened the meeting of the 6th congress of the Cuban Communist Party. After years of defending an equalitarian social system escaping the American guardianship, the economic structures of the pearl of Caribbean islands are questioned. The arrival of Arab Springs, which symbolize the revolt of the peoples towards authoritarian and stiff political and economic governance, is most probably linked to this sudden need to modify the economic structures existing in Cuba. To the menu, 291 measures are announced to improve the everyday life of Cubans, the monthly average wage of which is 12 euro. As for the relation which maintains Cuba with the EU, it takes on an especially bilateral dimension today: the common position of 1996 was modified indeed never, Member States adopting a different attitude according to the relations which they maintain with Cuba, from a political point of view as well as from a historic one.
Abril de 2011. La agitación en las calles testimonia que un evento capital para el futuro del país está preparándose: Raúl Castro convoco la reunión del 6to congreso del Partido Comunista Cubano. Después de anos reivindicando un sistema social igualitario que escapó a la tutela estadounidense, las estructuras económicas de la perla del Caribe están siendo cuestionadas. La llegada de las primaveras árabes, símbolo de la rebelión de los pueblos frente de una gobernanza política y económica autoritaria y rígida, probablemente no es ajena extranjera a esta necesidad súbita de modificar las estructuras económicas existentes en Cuba. Como parte del programa, 291 medidas son anunciadas para mejorar la vida diaria del cubano, cuyo salario medio mensual es de 12 euros. En cuanto a la relación que tiene Cuba con la UE, reviste hoy una dimensión sobre todo bilateral: en efecto, la posición común de 1996 no ha sido modificada, dado que los Estados Miembros adoptan una actitud diferente según las relaciones que mantienen) con Cuba, tanto desde un punto de vista político como histórico.
Cuba
Martinique

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.6297
http://journals.openedition.org/etudescaribeennes/6297

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The formation age of the Siberian cratonic mantle is not well established as yet. Re–Os data on various mantle-derived materials have shown that it contains Archaean components, but the reported Re-depletion ages show a broad variation range (3.4 to 1 Ga) and are commonly ≤ 2 Ga for peridotite xenoliths. We report Hf and Nd isotope data for cpx and garnet separated from nine refractory spinel and garnet peridotite xenoliths from the Udachnaya kimberlite. The cpx from low-opx spinel harzburgites show extremely high εHf values, from + 607 to + 2084, which testify to long-term evolution of these rocks with high Lu/Hf ratios, consistent with their residual origin and near absence of post-melting enrichments in the Lu–Hf system. Such high εHf values are unusual for cpx from other cratonic peridotites and are higher than those reported for depleted cpx in off-cratonic peridotites. The clinopyroxenes from low-opx spinel harzburgites yield Hf model ages from 1.9 to 1.7 Ga while the cpx from high-opx spinel harzburgites yield Hf model ages from 3.0 to 1.9 Ga. When plotted together, they define a Lu/Hf isochron with an age of 1.80 Ga, which we consider as a robust estimate of the formation age (melt extraction event) because it is obtained on residual rocks that show no evidence for HREE and Hf enrichments and because the model ages for three out of four individual samples are similar to each other. The cpx have high εNd of + 94 to + 123, which are inconsistent with their low Sm/NdPM of < 1 and yield no meaningful age estimates. The consistently high, positive εNd in these cpxs can be interpreted in terms of long-term evolution of refractory peridotites with high Sm/Nd, followed by relatively recent LREE enrichments.We infer that a significant part of the lithospheric mantle in the central Siberian craton may have been formed during a major event (or a series of events) at around 1.8 Ga. Older ages reported for the central Siberian craton may refer to less common materials from cratonic or other domains formed in the Archaean that were later incorporated into the cratonic roots. The transition from the “Archaean” to “modern” tectonic regimes in Siberia and possibly elsewhere may have taken place at 1.8–1.9 Ga rather than at ~ 2.5 Ga, i.e. in the second half of the Paleoproterozoic rather than at the Archaean–Proterozoic boundary, at which time the asthenospheric mantle became generally too cold to experience high-degree melting on a large scale. The ~ 1.8 Ga formation age of the Siberian cratonic mantle is coeval with that for a major part of the ancient continental crust in the central Siberian craton. The temporal crust–mantle links may be explained either by the generation of the initial source materials for continental crust in the same melting event that formed the residual peridotites or, alternatively, by subduction and melting of pre-existing proto-lithosphere destabilized by a major mantle upwelling that formed the residual mantle.
ISSN: 0009-2541

hal-01115519
https://hal.archives-ouvertes.fr/hal-01115519
DOI : 10.1016/j.chemgeo.2014.10.018

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The mycotoxin alternariol (AOH), a frequent contaminant in fruit and grain, is known to induce cellular stress responses such as reactive oxygen production, DNA damage and cell cycle arrest. Cellular stress is often connected to autophagy, and we employed the RAW264.7 macrophage model to test the hypothesis that AOH induces autophagy. Indeed, AOH treatment led to a massive increase in acidic vacuoles often observed upon autophagy induction. Moreover, expression of the autophagy marker LC3 was markedly increased and there was a strong accumulation of LC3-positive puncta. Increased autophagic activity was verified biochemically by measuring the degradation rate of long-lived proteins. Furthermore, AOH induced expression of Sestrin2 and phosphorylation of AMPK as well as reduced phosphorylation of mTOR and S6 kinase, common mediators of signaling pathways involved in autophagy. Transmission electron microscopy analyzes of AOH treated cells not only clearly displayed structures associated with autophagy such as autophagosomes and autolysosomes, but also the appearance of lamellar bodies. Prolonged AOH treatment resulted in changed cell morphology from round into more star-shaped as well as increased β-galactosidase activity. This suggests that the cells eventually entered senescence. In conclusion, our data identify here AOH as an inducer of both autophagy and senescence. These effects are suggested to be to be linked to AOH-induced DSB (via a reported effect on topoisomerase activity), resulting in an activation of p53 and the Sestrin2-AMPK-mTOR-S6K signaling pathway.
ISSN: 0300-483X

hal-01117627
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117627
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117627/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117627/file/Autophagy%20and%20senescence_accepted.pdf
PUBMED : 25456271

Éditeur(s) : Oxford university press
Résumé : There is increasing evidence from previous studies, and from fishers' observations, that coastal dolphins use fishing nets as an easily accessible feeding source, damaging or depredating fish caught in the nets. This study investigates the impact of dolphin depredation on artisanal trammelnets by analysing the catch composition of 614 artisanal fishing operations in the Bonifacio Strait Natural Reserve (France). Common bottlenose dolphins (Tursiops truncatus) attacked, on average, 12.4% of the nets and damaged 8.3% of the catch. However, attacked nets were characterized by statistically significantly higher catch per unit effort than unattacked ones. Catch composition also differed significantly after dolphin attacks; bentho-pelagic fish were more represented and reef-associated fish less represented. Our results suggest that (i) dolphins are attracted by high fish densities in the fishing area and/or nets, and (ii) their attacks induce specific fish-avoidance behaviour, according to the fish position in the water column. Although dolphins depredate a small part of the catch, damage to nets, not yet assessed in this area, could weaken the benefits that reserves can provide to artisanal fisheries.
ICES Journal of Marine Science (1054-3139) (Oxford university press), 2009-05 , Vol. 66 , N. 4 , P. 699-707

Droits : 2009 ICES/CIEM. Oxford Journals
http://archimer.ifremer.fr/doc/2009/publication-6808.pdf
DOI:10.1093/icesjms/fsp036
http://archimer.ifremer.fr/doc/00000/6808/

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999
Résumé : French Polynesia started it's Fish Aggregating Device programme in June 1981 with the positioning of the first buoy offshore of the main island of Tahiti. Since then, 251 structures have been installed throughout the 5 archipelagoes of this French overseas territory. The shape and size of the devices have evolved 8 times over this period, however, a single model has not yet been adopted. Trials are currently underway using lighter structures similar to those found in the Indian Ocean. The anchoring lines have progressively been modified through better knowledge of material and product availability, as well as better understanding of environmental constraints. The programme is entirely financed by the territorial government and managed by the public sector. This ongoing technical assistance, aimed towards the local small-scale coastal fishery, is considered an important factor to maintaining this activity alive. Up until 1997, this economical support policy of outer island populations far from the metropolis central town, along with incidental fishing methods around FADs, have given mitigated results without nevertheless putting into cause this programme. The use of 'drifting handlines' retained at the surface by small indicator floats are one of the contributing factors to the degradation of the anchor lines. It is now commonly accepted that a new fishing strategy must be adopted so that professional coastal fishermen become more aware with regards to an expensive work tool due to local bathymetric conditions, so that fishing effort is increased through the development of better adapted fishing techniques, and finally so that community spirit rules over individualism.Original Abstract: Le programme d'ancrage de DCP en Polynesie francaise a vu le jour en juin 1981 avec l'implantation d'un premier dispositif au large des cotes de Tahiti. Depuis cette date, ce sont 251 structures qui ont ete installees dans les cinq archipels de ce pays d'outre-mer. La forme et la taille des bouees ont evolue huit fois sans etre definitivement arretees a un seul modele et des essais sur des structures legeres de type " Ocean Indien " sont en cours. Les lignes d'ancrage ont fait l'objet de modifications progressives en raison de meilleures connaissances des produits ainsi que des contraintes du milieu environnant. Ce programme est finance en totalite par le territoire de la Polynesie francaise et gere par le secteur public. Il s'adresse a la pecherie artisanale et cotiere qui considere depuis de nombreuses annees cette assistance technique comme un atout indispensable au maintien de son activite. La politique d'engagement de ce soutien economique jusqu'en 1997 aupres des populations d'iles et atolls tres eloignes de la capitale ainsi que l'incidence de la technique de peche la plus repandue autour des DCP ont abouti a des resultats mitiges sans pour autant remettre en cause ce programme. En effet, les lignes a main derivantes et retenues en surface par une petite bouee temoin sont un des principaux facteurs de degradation des lignes d'ancrage. Il est desormais reconnu par tous les intervenants qu'une nouvelle strategie doit etre deployee afin que les pecheurs cotiers professionnels soient mieux responsabilises face a un outil de travail onereux en raison de la bathymetrie environnante, pour que l'effort de peche soit accru par l'utilisation de techniques de peche mieux adaptees, et enfin que l'esprit communautaire prime sur l'individualisme.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00042/15292/12649.pdf
http://archimer.ifremer.fr/doc/00042/15292/

Éditeur(s) : PSIC 11 - 11th Pacific Science Inter-Congress : Pacific Countries and their Ocean: Facing Local and Global Changes / 2nd Symposium on French Research in the Pacific. March 2 - 6, 2009 Tahiti, French Polynesia.
Résumé : Meiofauna is a functional group made of small benthic metazoans 45 to 500µm in size. Although protista, foraminifera living in this kind of environment are often put in to the meiofauna. Meiofauna has been studied in New Caledonia for its double role as biological indicator for monitoring pond health status and as shrimp forage. Suitability of EOM (easily oxidized material), SOD(sediment oxygen demand),as new biochemical tools for monitoring shrimp pond health was assessed in an environmental survey aiming to assess the role of the water/sediment interface in the occurrence of the summer syndrome vibriosis. EOM, SOD and redox were correlated with shrimp survivals. Lowest meiofauna biomass and abundance were concomitantly found in the most polluted station. Proportion of abnormal tests over exceeding the one found in areas subjected to natural ecological stress were collected and were positively related to EOM and SOD and negatively to redox. Shrimp pond dominant species are common to estuaries and lagoons. But foraminifera abnormal behaviour indicates specific shrimp pond conditions

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00198/30876/29244.pdf
http://archimer.ifremer.fr/doc/00198/30876/

Éditeur(s) : HAL CCSD
Résumé : International audience
BackgroundTree above ground biomass (AGB) is currently estimated by tree-level allometrical models that take into account, tree volume estimated from proxy variables of tree size (DBH) and species average wood specific gravity (WSG). These methods are common and realistic from a practical point of view. However, they do not take into account deviance from fixed allometrical trajectories and species or tree level WSG variations. Here, we present Xtrawood software that allows computation of tree AGB according to structure and WSG variations.MethodXtrawood reconstructs tree structure and integrates WSG variations by merging tree structure and WSG data measured at different position in trees, leading to the computation of global AGB and visualization of WSG variation along tree structure. Tree structure is measured according to stem dimensions (length, diameter) and positions within tree, and encoded in Multiscale Tree Graph format (MTG). WSG data is made of radial WSG profiles (1 measure each 0,5 cm from pith to bark) sampled at different heights within whole tree. Xtrawood output are illustrated using a dataset collected on an Amazonian forest ‘biomass dominant species’, Dicorynia guianensis Amsh., also known to exhibit substantial WSG gradients along both radial and vertical axis. 9 trees ranging from 15 to 60 cm DBH were measured by climbers. Each tree was felled and samples were collected at different positions (3 in trunk, 1 to 5 in crown) to record WSG radial profiles.ResultsXtrawood allows computation of tree volume, but also visualization of WSG variations in tree as well as inference of WSG radial profiles at different heights. Output variables are decomposed according to different tree scale and locations (axis, trunk/crown) and easy to extract. Xtrawood results will be compared to those of standard estimation method and can be used to identify positions in trees where WSG value leads to the better estimate of tree AGB.Conclusion/perspectiveXtrawood produces AGB estimate with data from intensive measurements practices. The sampling protocol, used here, remains destructive and time-consuming because Xtrawood is not directly dedicated to forest managers, but to help calibration of realistic sampling strategies. Moreover, Xtrawood offers a way to understand relationships between tree development, WSG variations within tree structure and biomass accumulation in the context of natural forests or plantations. A software demo is available at coffee break.
53rd Annual Meeting of the Association for Tropical Biology and Conservation (ATBC 2016)
Montpellier, France

Droits : http://creativecommons.org/licenses/by/
hal-01349613
https://hal.archives-ouvertes.fr/hal-01349613

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Neonatal infection constitutes one of Senegal’s most important public health problems, with amortality rate of 41 deaths per 1,000 live births.Methods: Between January 2007 and March 2008, 242 neonates with suspected infection were recruited at threeneonatal intensive care units in three major tertiary care centers in Dakar, the capital of Senegal. Neonatal infections wereconfirmed by positive bacterial blood or cerebrospinal fluid culture. The microbiological pattern of neonatal infectionsand the antibiotic susceptibility of the isolates were characterized. In addition, the genetic basis for antibiotic resistanceand the genetic background of third-generation cephalosporin-resistant (3GC-R) Enterobacteriaceae were studied.Results: A bacteriological infection was confirmed in 36.4 % (88/242) of neonates: 22.7 % (30/132) during the early-onsetand 52.7 % (58/110) during the late-onset periods (p > 0.20). Group B streptococci accounted for 6.8 % of the 88 collectedbacterial isolates, while most of them were Enterobacteriaceae (n = 69, 78.4 %). Of these, 55/69 (79.7 %) were 3GC-R. TheblaCTX-M-15 allele, the blaSHV and the blaTEM were highly prevalent (63.5, 65.4 and 53.8 %, respectively), usually associatedwith qnr genes (65.4 %). Clonally related strains of 3GC-R Klebsiella pneumoniae and 3GC-R Enterobacter cloacae, the twomost commonly recovered 3GC-R Enterobacteriaceae (48/55), were detected at the three hospitals, underlining the roleof cross-transmission in their spread. The overall case fatality rate was 18.6 %.Conclusions:Measures should be taken to prevent nosocomial infections and the selection of resistant bacteria
ISSN: 1471-2334

Droits : http://creativecommons.org/licenses/by/
hal-01473613
https://hal.archives-ouvertes.fr/hal-01473613
https://hal.archives-ouvertes.fr/hal-01473613/document
https://hal.archives-ouvertes.fr/hal-01473613/file/High%20third-generation%20cephalosporin%20resistant%20Enterobacteriaceae%20prevalence%20rate%20among%20neonatal%20infections%20in%20Dakar%2C%20Senegal.pdf
DOI : 10.1186/s12879-016-1935-y

Éditeur(s) : HAL CCSD Elsevier Academic Press
Résumé : International audience
Marines Protected Areas (MPAs) are commonly used around the world as management tools to promote the sustainable use of marine resources. It is assumed that MPAs secure human livelihoods and well-being by protecting marine ecosystems and ecosystem services. However, the links between ecological effects of MPAs and services have rarely been explored. Here we review the different impacts of MPAs on ecosystem functioning and service provision. Results highlight that empirical evidence for positive effects of MPAs on ecosystem service provision by coastal marine ecosystems is accumulating. Finally, we identified knowledge gaps on which future research efforts could focus and empower marine resource managers to make more informed decisions and maximize the value derived from their natural resource base.
Aquatic Functional Biodiversity: an Ecological and Evolutionary Perspective

ISBN : 978-0-12-417015-5
hal-01199217
https://hal-univ-perp.archives-ouvertes.fr/hal-01199217
DOI : 10.1016/B978-0-12-417015-5.00009-8

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Ctenophores are a phylum of non-bilaterian marine (mostly planktonic) animals, characterised by several unique synapomorphies (e.g., comb rows, apical organ). Relationships between and within the nine recognised ctenophore orders are far from understood, notably due to a paucity of phylogenetically informative anatomical characters. Previous attempts to address ctenophore phylogeny using molecular data (18S rRNA) led to poorly resolved trees but demonstrated the paraphyly of the order Cydippida. Here we compiled an updated 18S rRNA data set, notably including a few newly sequenced species representing previously unsampled families (Lampeidae, Euryhamphaeidae), and we constructed an additional more rapidly evolving ITS1 + 5.8S rRNA + ITS2 alignment. These data sets were analysed separately and in combination under a probabilistic framework, using different methods (maximum likelihood, Bayesian inference) and models (e.g., doublet model to accommodate secondary structure; data partitioning). An important lesson from our exploration of these datasets is that the fast-evolving internal transcribed spacer (ITS) regions are useful markers for reconstructing high-level relationships within ctenophores. Our results confirm the paraphyly of the order Cydippida (and thus a ``cydippid-like'' ctenophore common ancestor) and suggest that the family Mertensiidae could be the sister group of all other ctenophores. The family Lampeidae (also part of the former ``Cydippida'') is probably the sister group of the order Platyctenida (benthic ctenophores). The order Beroida might not be monophyletic, due to the position of Beroe abyssicola outside of a clade grouping the other Beroe species and members of the ``Cydippida'' family Haeckeliidae. Many relationships (e.g. between Pleurobrachiidae, Beroida, Cestida, Lobata, Thalassocalycida) remain unresolved. Future progress in understanding ctenophore phylogeny will come from the use of additional rapidly evolving markers and improvement of taxonomic sampling.
ISSN: 0944-2006

hal-01544475
https://hal.archives-ouvertes.fr/hal-01544475
DOI : 10.1016/j.zool.2014.06.004