Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
The Lanzo peridotite massif is a fragment of oceanic lithosphere generated in an ocean-continent transition context and eclogitized during alpine collision. Despite the subduction history, the massif has preserved its sedimentary oceanic cover, suggesting that it may have preserved its oceanic structure. It is an exceptional case for studying the evolution of a fragment of the lithosphere from its oceanization to its subduction and then exhumation. We present a field and petrological study retracing the different serpentinization episodes and their impact on the massif structure. The Lanzo massif is composed of slightly serpentinized peridotites (<20% serpentinization) surrounded by an envelope of foliated serpentinites (100% serpentinization) bordered by oceanic metabasalts and metasedimentary rocks. The limit between peridotites and serpentinites defines the front of serpentinization. This limit is sharp: it is marked by the presence of massive serpentinites (80% serpentinization) and, locally, by dykes of metagabbros and mylonitic gabbros. The deformation of these gabbros is contemporaneous with the emplacement of the magma. The presence of early lizardite in the peridotites testifies that serpentinization began during the oceanization, which is confirmed by the presence of meta-ophicarbonates bordering the foliated serpentinite envelope. Two additional generations of serpentine occur in the ultramafic rocks. The first is a prograde antigorite that partially replaced the lizardite and the relict primary minerals of the peridotite during subduction, indicating that serpentinization is an active process at the ridge and in the subduction zone. Locally, this episode is followed by the deserpentinization of antigorite at peak P-T (estimated in eclogitized metagabbros at 2-2.5 GPa and 550-620 °C): it is marked by the crystallization of secondary olivine associated with chlorite and/or antigorite and of clinopyroxene, amphibole and chlorite assemblages. A second antigorite formed during exhumation partially to completely obliterating previous textures in the massive and foliated serpentinites. Serpentinites are an important component of the oceanic lithosphere generated in slow to ultraslow spreading settings, and in these settings, there is a serpentinization gradient with depth in the upper mantle. The seismic Moho limit could correspond to a serpentinization front affecting the mantle. This partially serpentinized zone constitutes a less competent level where, during subduction and exhumation, deformation and fluid circulation are localized. In this zone, the reaction kinetics are increased and the later steps of serpentinization obliterate the evidence of this progressive zone of serpentinization. In the Lanzo massif, this zone fully recrystallized into serpentinite during alpine subduction and collision. Thus, the serpentinite envelope represents the oceanic crust as defined by geophysicists, and the sharp front of serpentinization corresponds to an eclogitized seismic palaeo-Moho.
ISSN: 0263-4929

hal-00823051
https://hal.archives-ouvertes.fr/hal-00823051
DOI : 10.1111/jmg.12008

Éditeur(s) : HAL CCSD
Résumé : International audience
OBJECTIVE: To analyze complications of endoscopic transsphenoidal surgery (ETS) for nonfunctioning pituitary macroadenomas (NFPAs).ăMETHODS: A retrospective study of 300 NFPAs was performed. Complications and factors that could influence these complications were analyzed.ăRESULTS: Visual and pituitary functions worsened in 2.4% and 13.7% of cases, respectively. Postoperative diabetes insipidus was permanent in 6.2% of cases. Postoperative meningitis occurred in 3.3% of patients. Meningitis was strongly associated with intraoperative cerebrospinal fluid (CSF) leaks (P = 0.01), postoperative CSF leaks (P = 0.0001), and operation times longer than 1 hour (P = 0.023). Detection of Staphylococcus aureus and preoperative treatment with mupirocin in the nostrils did not impact the occurrence of meningitis. Two patients with meningitis died (unique causes of death). Postoperative CSF leaks occurred in 2.7% of cases and were associated with intraoperative CSF leaks (P = 0.007) and permanent diabetes insipidus (P = 0.028). The rate of CSF leak decreased from 4% to 0.8% (P = 0.048) after we moved from a soft to hard reconstruction of the sella. The rate of postoperative epistaxis decreased from 6.7% to 1.25% after we stopped using monopolar coagulation (P = 0.013).ăCONCLUSIONS: ETS permits a wide view, allowing good conditions for a satisfactory resection in the majority of NFPAs. Some pitfalls of endoscopy can lead to complications that improve with modification of the operative technique (i.e., CSF leak and postoperative epistaxis). This study confirms an acceptable rate of complications associated with ETS.
World Neurosurgery

hal-01474296
https://hal.archives-ouvertes.fr/hal-01474296
DOI : 10.1016/j.wneu.2016.02.059
PUBMED : 26902781

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
The influence of magnetic interactions on the anisotropy of magnetic susceptibility (AMS) have been largely studied by several theoretical models or experiments. Numerical models have shown that when magnetostatic interactions occur, the distributions of particles over the volume rather than their individual orientations control the AMS. We have shown recently from a comprehensive rock magnetic study and from a theoretical 2-dimensional (2-D) model that single domain particles closely packed in globule aggregates could produce strong local random interaction magnetic fields which could influence the magnetic susceptibility and decrease the degree of anisotropy. In this paper, we first present in detail this 2-D theoretical model and then we extend it to the 3-D case. The possible distribution function of the magnetostatic interaction fields comprises two extreme states: it is either isotropic or ordered. The former case corresponds to the thermal-demagnetized state while the second case corresponds to the alternating field (AF) demagnetized state. We show that when easy axes of magnetization are not uniformly distributed, the degree of anisotropy decreases as the interaction field increases in both AF- and thermal-demagnetized states in 2-D and 3-D geometry. Thus we conclude that random magnetic fields generated by a random arrangement of magnetic particles over the sample volume decrease the degree of anisotropy of AMS and may alter the magnetic fabric.
ISSN: 0039-3169

hal-00758113
https://hal.archives-ouvertes.fr/hal-00758113
https://hal.archives-ouvertes.fr/hal-00758113/document
https://hal.archives-ouvertes.fr/hal-00758113/file/SGEG-2012-HAL.pdf
DOI : 10.1007/s11200-010-9097-7

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Background We conducted this systematic review and meta-analysis to address the open question of a possible association between the socioeconomic level of the neighborhoods in which pregnant women live and the risk of Congenital Heart Defects (CHDs), Neural Tube Defects (NTDs) and OroFacial Clefts (OFCs). Methods We searched MEDLINE from its inception to December 20th, 2015 for case-control, cohort and ecological studies assessing the association between neighborhood socioeconomic level and the risk of CHDs, NTDs and the specific phenotypes Cleft Lip with or without Cleft Palate (CLP) and Cleft Palate (CP). Study-specific risk estimates were pooled according to random-effect and fixed-effect models. Results Out of 245 references, a total of seven case-control studies, two cohort studies and two ecological studies were assessed in the systematic review; all studies were enrolled in the meta-analysis with the exception of the two cohort studies. No significant association has been revealed between CHDs or NTDs and neighborhood deprivation index. For CLP phenotype subgroups, we found a significantly higher rate in deprived neighborhoods (Odds Ratios (OR) = 1.22, 95% CI: 1.10, 1.36) whereas this was not significant for CP phenotype subgroups (OR = 1.20, 95%CI: 0.89, 1.61). Conclusion In spite of the small number of epidemiological studies included in the present literature review, our findings suggest that neighborhood socioeconomic level where mothers live is associated only with an increased risk of CLP phenotype subgroups. This finding has methodological limitations that impede the formulation of firm conclusions, and further investigations should confirm this association. © 2016 Deguen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ISSN: 1932-6203

hal-01406070
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01406070
DOI : 10.1371/journal.pone.0159039
PUBMED : 27783616

Éditeur(s) : Neidine editeurs
Résumé : This article calls back first of all a set of facts relative to the main stakes considering sea and ocean so much on the economic point of view, in the scientific technological and innovative fields, in the governance aspects as also in the culture and international prestige ones. Then the article synthesizes several of the elements of the European study on the blue growth, the established priorities, the results of the study and its recommendations. The case of New Caledonia is then analyzed which shows that considering the 11 economic priorities identified by the European Union, 10 interest or may interest this ultra-marine country. A focus is proposed on a second European study which concerns the implementation of a Blue Society (Sea for Society Project) and in synthesis and perspectives the authors wonder about the possibilities and the profits which New Caledonia could take advantage of the implementation of a maritime and marine strategy based on the principles of blue growth and blue society.
Cet article rappelle tout d’abord un ensemble de faits relatifs aux grands enjeux de la maritimisation tant au plan de l’économie, de la science, de la technologie et de l’innovation, de la gouvernance comme également de la culture et du rayonnement international. Ensuite l’article synthétise plusieurs des éléments de l’étude européenne sur la croissance bleue, les priorités établies, les résultats de l’étude et ses recommandations. Le cas de la Nouvelle-Calédonie est alors abordé qui montre que sur les 11 priorités économiques identifiées par l’Europe, 10 intéressent ou sont susceptible d’intéresser ce pays ultra-marin. Un focus est proposé sur une seconde étude européenne qui concerne la mise en place d’une Société Bleue et en synthèse et perspectives les auteurs s’interrogent sur les possibilités et bénéfices que la Nouvelle-Calédonie pourrait tirer de la mise en place d’une stratégie maritime et marine basée sur les principes de croissance et de société bleues.
Tai Kona (2269-7535) (Neidine editeurs), 2013-11 , N. 5 , P. 12-35

Droits : Tai Kona
http://archimer.ifremer.fr/doc/00174/28505/26854.pdf
http://archimer.ifremer.fr/doc/00174/28505/

Éditeur(s) : HAL CCSD
Résumé : This work is devoted to the theoritical research and to the numerical calculus of weak solutions (in the sens of generalized functions) for the non linear transport equation((∂u)/(∂t))(x,y,t)+a(x,y,t)((∂f(u))/(∂x))(x,y,t)+b(x,y,t)((∂g(u))/(∂y))(x,y,t)=0 pour t>0with the initial condition u(x,y,0)=u₀(x,y) where the functions {(x,y,t)→a(x,y,t)} and {(x,y,t)→b(x,y,t)} belong to L^{∞}(R²×R⁺) (but can be discontinuous), the functions f and g are smooth and monotonous, the function {(x,y)→u₀(x,y)} belongs to L^{∞}(R²). We recall the necessary notions on nonlinear generalized functions for introducing their tensorial product. The main results (to determine the weak solutions) are sufficient conditions so that, when a sum of généralized functions (like Heaviside or Dirac products) is associated with zero, each terms of the sum is equal to zero. Thanks to these theoretical results, we can solve the Riemann problem with the help of a solver written like tensorial product of Heaviside functions (or like a sum of tensorial product of Heaviside functions) in order to obtain the weak solutions. These weak solutions allow to develop two dimensional numerical Godunov type schemes. Then, numerical tests are performed which give a comparison between the results obtained by these 2D schemes and the ones of the splitting method. These tests prove that the 2D numerical schemes are as reliable as the ones obtained by splitting. They are also more simple in their expression. Moreover, a more detailed comparative study of the two types of numerical schemes show that the 2D schemes are far less expensive in the linear case as well as in the non linear case. They are stable for the L^{∞} norm, unlike the splitting schemes. At least some perspectives as well as an existence theorem of a strong solution "almost eveywhere" for linear hyberbolic systems are studied.
Nous nous intéressons à la recherche et au calcul numérique de solutions faibles (au sens des fonctions généralisées) de l'équation de transport non linéaire((∂u)/(∂t))(x,y,t)+a(x,y,t)((∂f(u))/(∂x))(x,y,t)+b(x,y,t)((∂g(u))/(∂y))(x,y,t)=0 pour t>0complétée de la condition initiale : u(x,y,0)=u₀(x,y) où les fonctions {(x,y,t)→a(x,y,t)} et {(x,y,t)→b(x,y,t)} appartiennent à L^{∞}(R²×R⁺) (mais peuvent être discontinues), les fonctions f et g sont lisses et monotones, la fonction {(x,y)→u₀(x,y)} appartient à L^{∞}(R²). Des rappels sur les fonctions généralisées nous permettent d'introduire leur produit tensoriel. Un des résultats clés (pour déterminer ultérieurement les solutions faibles cherchées) donne des conditions suffisantes pour que, lorsqu'une somme de fonctions généralisées (de type produit d'Heaviside ou de Dirac) est associée à 0, chacun des termes de la somme est nul. Grâce à ces résultats théoriques, on résout le problème de Riemann 2D à l'aide d'un solveur s'écrivant comme produit tensoriel de fonctions type Heaviside (ou comme somme de produit tensoriel de fonctions type Heaviside) afin d'obtenir les solutions faibles. Ces solutions faibles permettent la construction des schémas numériques de type Godunov 2D. Nous les validons par des test numériques comparant les résultats obtenus par ces schémas 2D et ceux de la méthode du splitting. Ces tests montrent que les schémas numériques 2D sont aussi fiables que ceux par splitting, alors qu'ils sont plus simples dans leur écriture. Une étude comparative plus complète entre les deux types de schémas numériques montre de plus que les schémas 2D sont nettement moins coûteux à la fois dans les cas linéaire et non linéaire et qu'ils sont stables pour la norme L^{∞}, contrairement aux schémas par splitting. Enfin des perspectives ainsi qu'un théoréme d'existence de solutions fortes "presque partout" pour des systèmes hyperboliques linéaires sont abordés.
https://hal.archives-ouvertes.fr/tel-01487366

Droits : info:eu-repo/semantics/OpenAccess
tel-01487366
https://hal.archives-ouvertes.fr/tel-01487366
https://hal.archives-ouvertes.fr/tel-01487366/document
https://hal.archives-ouvertes.fr/tel-01487366/file/th%C3%A8se_olivier_jouannelle_HAL.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Home health care workers interventions have been implemented in western countries to improve health status of patients with respiratory diseases especially asthma and allergic illnesses. Twenty-six controlled studies dealing with prevention and control of these diseases through home environmental interventions were reviewed. After a comprehensive description of the characteristics of these studies, the effectiveness of each intervention was then evaluated in terms of participants' compliance with the intervention program, improvement of quality of the indoor environment, and finally improvement of health outcomes, in detailed tables. Limitations and biases of the studies are also discussed. Overall, this review aims at giving a toolbox for home health care workers to target the most appropriate measures to improve health status of the patient depending on his and/or her environment and disease. Only a case-by-case approach with achievable measures will warrant the efficacy of home interventions. This review will also provide to the research community a tool to better identify targets to focus in future evaluation studies of home health care workers action.
Journal of allergy and clinical immunology. In practice

hal-01477202
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477202
DOI : 10.1016/j.jaip.2016.07.011
PUBMED : 27665387

Éditeur(s) : World Aquaculture Society, Aquaculture 2006
Résumé : Oysters are among the most familiar of all marine invertebrate taxa. However our knowledge of oyster phylogeny and systematics is fragmentary. This is principally due to the plastic growth patterns of these animals, which result in a wide range of overlapping, ecophenotypic variants that greatly reduce the value of analysis based on shell morphology. Besides that, many intentional or accidental anthropogenic transfers have emphasised this situation. In several cases of misclassification or misidentification of oysters, DNA molecular data, have provided valuable new insights on the tracing of introductions or more generally on the phylogeographic relationships between oyster species. We will illustrate this issue with recent case studies from our lab on several flat and cupped oysters: (1) the Crassostrea gigas – Crassostrea angulata couple of Asian species and their successive introductions in Europe, (2) the new species of cupped oysters, Crassostrea honkongensis, described in Hong-Kong and very divergent from the species Crassostrea gigas it was initially supposed to be, (3) the mangrove oyster Crassostrea gasar that was shown not only to be present along the coasts of Western Africa but also along the Atlantic coasts of South America, and (4) the geographic disjunction between Ostreola stentina, described in the Mediterranean Sea, and the genetically closely related species Ostrea aupouria (from New Zealand) and Ostreola equestris (from Mexico Gulf/Atlantic). At the intra specific level, we will focus on one of the main documented case in Europe, the flat oyster, Ostrea edulis. It is a marine bivalve whose natural geographical distribution ranges along the European Atlantic coast from Norway to Morocco, in addition to the Mediterranean and Black Sea. Studies of allozymes, microsatellites and mitochondrial differentiation over the whole range concluded that a significant divergence existed between Mediterranean and Atlantic populations, together with an isolation-by-distance pattern. However, the average mitochondrial haplotypic diversity displayed a high among populations variance, reflecting smaller effective population size in some locations. Additionally, a ten-fold quantitative difference was observed in the same study in Fst between the mitochondrial and the nuclear genomes, which could be due to sex biased differential reproductive success between males and females. In order to further document this hypothesis, two experiments at the population level were conducted. First, brooding females were sampled in a wild population and the number of males fertilizing a given female estimated. Then, parentage analyses were achieved under experimental conditions: successive mass spawnings were collected from a population of potential genitors kept in hatchery, whose genotypes were known, in order to infer a posteriori the relative contribution of each genitor. Moreover, we aimed to better understand the reproduction dynamics of this species. Several patterns of spawning could be distinguished: unique, successive or extended in time. The different parental contributions and reproductive behaviors observed in these experiments are discussed in the context of the hypothesis of a variance in the reproductive success of males and females and consequences in local and temporal reduced effective population sizes.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2006/acte-3475.pdf
http://archimer.ifremer.fr/doc/00000/3475/

Éditeur(s) : University of Tasmania, Université de Bretagne Occidentale
Résumé : Empirical evidence and the theoretical literature both point to stock sustainability and the protection of marine biodiversity as important fisheries management issues. Decision-support tools are increasingly required to operationalize the ecosystem-based approach to fisheries management. These tools need to integrate (i) ecological and socio-economic drivers of changes in fisheries and ecosystems; (ii) complex dynamics; (iii) deal with various sources of uncertainty; and (iv) incorporate multiple, rather than single objectives. The stochastic co-viability approach addresses the trade-offs associated with balancing ecological, economic and social objectives throughout time, and takes into account the complexity and uncertainty of the dynamic interactions which characterize exploited ecosystems and biodiversity. This thesis proposes an application of this co-viability approach to the sustainable management of mixed fisheries, using two contrasting case studies: the French Bay of Biscay (BoB) demersal mixed fishery and the Australian Northern Prawn Fishery (NPF). Both fisheries entail direct and indirect impacts on mixed species communities while also generating large economic returns. Their sustainability is therefore a major societal concern. A dynamic bio-economic modelling approach is used to capture the key biological and economic processes governing these fisheries, combining age- (BoB) or size- (NPF) structured models of multiple species with recruitment uncertainty, and multiple fleets (BoB) or fishing strategies (NPF). Economic uncertainties relating to input and output prices are also considered. The bioeconomic models are used to investigate how the fisheries can operate within a set of constraints relating to the preservation of Spawning Stock Biomasses (BoB) or Spawning Stock Size Indices (NPF) of a set of key target species, maintenance of the economic profitability of various fleets (BoB) or the fishery as a whole (NPF), and limitation of fishing impacts on the broader biodiversity (NPF), under a range of alternative scenarios and management strategies. Results suggest that under a status quo strategy both fisheries can be considered as biologically sustainable, while socio-economically (and ecologically in the NPF case) at risk. Despite very different management contexts and objectives, viable management strategies suggest a reduction in the number of vessels in both cases. The BoB simulations allow comparison of the trade-offs associated with different allocations of this decrease across fleets. Notably, co-viability management strategies entail a more equitable allocation of effort reductions compared to strategies aiming at maximizing economic yield. In the NPF, species catch diversification strategies are shown to perform well in controlling the levels of economic risk, by contrast with more specialized fishing strategies. Furthermore analyses emphasize the importance to the fishing industry of balancing global economic performance with inter-annual economic variability. Promising future developments based on this research involve the incorporation of a broader set of objectives including social dimensions, as well as the integration of ecological interactions, to better address the needs of ecosystem-based approaches to the sustainable harvesting of marine biodiversity.
L’objectif général de la thèse est de modéliser les principaux processus biologiques et économiques régissant des pêcheries multi-espèces et multi-flottilles afin de proposer des stratégies viables pour la gestion durable de ces pêcheries mixtes, dans un contexte stochastique et multiobjectif. Plus spécifiquement, cette thèse utilise des analyses de co-viabilité stochastique pour étudier les arbitrages entre des objectifs contradictoires de gestion (conservation, et viabilité économique et sociale) des pêcheries mixtes. Deux pêcheries mixtes sont analysées dans cette thèse: la pêcherie française mixte démersale du golfe de Gascogne et la pêcherie crevettière australienne du Nord (NPF). Ces deux pêcheries sont multi-espèces, et utilisent des stratégies multiples de pêche, induisant des impacts directs et indirects sur les écosystèmes. Cette thèse propose une application de la co-viabilité stochastique à ces deux cas, en prenant en compte leur histoire, leur contexte socio-politique et les différences dans les stratégies et objectifs de gestion. Les résultats suggèrent que le status quo peut être considéré comme une stratégie biologiquement durable mais socio économiquement à risque dans les deux pêcheries (ainsi qu’à risque écologique dans le cas de la pêcherie australienne). Les simulations réalisées pour le golfe de Gascogne permettent de comparer les arbitrages associés à différentes réductions de capacités par flottille et de montrer qu’il existe des solutions de gestion permettant la co-viabilité du système (viabilité biologique des différentes espèces considérées et viabilité socio-économique des flottilles) contrairement à des stratégies de gestion mono-spécifiques ou basées sur la maximisation de la rente. Dans la pêcherie crevettière australienne, l’analyse montre que les stratégies de diversification permettent de limiter le risque économique contrairement aux stratégies plus spécialisées.

Droits : UBO, Univ. Tasmania
http://archimer.ifremer.fr/doc/00206/31731/30134.pdf
http://archimer.ifremer.fr/doc/00206/31731/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Humans are exposed to a large number of contaminants, many of which may have similar health effects. This paper presents a framework for identifying pollutants to be included in a cumulative risk assessment approach. To account for the possibility of simultaneous exposure to chemicals with common toxic modes of action, the first step of the traditional risk assessment process, i.e. hazard identification, is structured in three sub-steps: (1a) Identification of pollutants people are exposed to, (1b) identification of effects and mechanisms of action of these pollutants, (1c) grouping of pollutants according to similarity of their mechanism of action and health effects. Based on this exposure-based grouping we can derive "multi-pollutant" toxicity reference values, in the "dose-response assessment" step. The approach proposed in this work is original in that it is based on real exposures instead of a limited number of pollutants from a unique chemical family, as traditionally performed. This framework is illustrated by the case study of semi-volatile organic compounds in French dwellings, providing insights into practical considerations regarding the accuracy of the available toxicological information. This case study illustrates the value of the exposure-based approach as opposed to the traditional cumulative framework, in which chemicals with similar health effects were not always included in the same chemical class.
ISSN: 0013-9351

hal-00982315
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00982315
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00982315/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00982315/file/An_exposure-based_framework_for_grouping_pollutants_accepted.pdf
DOI : 10.1016/j.envres.2014.01.007

Éditeur(s) : HAL CCSD
Résumé : This paper presents a collection of wood species with important uses in musical instruments, in reference to historical and geographical cultural specificities, with ranges of viscoelastic vibrational properties by species. Data combine our experimental characterizations and extensive literature review, gathered in a specific relational database. An overview of vibrational properties' distribution on c.400 species is introduced. Two case studies of wood choices for a given function in different epochs or regions are presented: woods for European historical bows, and woods for idiophone bodies in different continents. Trends are contrasted: very different properties associated to historical changes in the first case; some common features over different regions in the second one.
Proceedings of the International Conference of COST Action IE0601 Wood Science for the Preservation of Cultural Heritage
Braga, Portugal

hal-00808403
https://hal.archives-ouvertes.fr/hal-00808403
https://hal.archives-ouvertes.fr/hal-00808403/document
https://hal.archives-ouvertes.fr/hal-00808403/file/Vibrational_properties_tropical_wood_Bremaud_al.pdf

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Cette étude emploie la théorie de la cointégration d’Engels et Granger pour analyser les relations entre développement touristique, croissance économique et réduction de la pauvreté en Haïti. Elle permet de tirer des enseignements et déduire des implications sur les liens de causalité entre ces trois variables. Les résultats montrent que ces dernières sont cointégrées et qu’au seuil de 5 %, les relations, d’une part entre croissance économique et développement touristique sont unidirectionnelles, c’est-à-dire que la croissance économique engendre du développement touristique en Haïti et non l’inverse. D’autre part, il existe également une relation unidirectionnelle entre réduction de la pauvreté et développement touristique. Autrement dit, la réduction de la pauvreté qui, souvent, mais pas toujours dépend de la croissance économique se traduirait ici par du développement touristique et non l’inverse.
This study, using cointegration and causality tests, investigates the relationship among tourism development, economic expansion, and poverty reduction in Haiti. fmpirical studies have shown that the three variables are cointegrated with a long-run stable relationship among the three. At 5% level, the causality tests suggest one-way Granger causal relation between economic growth and tourism development, and between poverty reduction and tourism development. On the other hand, the paper presents arguments in support of the proposition that poverty reduction as a source of tourism development, offers a convincing case for the use of policy instruments focused to drive a tourism-based economy.
Haïti

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.3780
http://journals.openedition.org/etudescaribeennes/3780

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Care for malaria patients in endemic areas has been improved through the increasing use of Rapid Diagnostic Tests (RDTs). Most RDTs target the histidine-rich protein-2 antigen (PfHRP2) to detect P. falciparum, as it is abundant and shows great heat stability. However, their use in South America has been widely questioned following a recent publication that pinpoints the high prevalence of Peruvian field isolates lacking the gene encoding this protein. In the remote rural health centers of French Guiana, RDTs are the main diagnosis tools. Therefore, a study of PfHRP2 RDT performances and pfhrp2 genotyping was conducted to determine whether a replacement of the current pLDH-based kit could be considered. The performance study compared the SD Malaria Ag test P.f/Pan® kit with the current gold standard diagnosis by microscopy. The prevalence of pfhrp2 and pfhrp3 deletions were evaluated from 221 P. falciparum isolates collected between 2009 and 2011 in French Guiana. Between January 2010 and August 2011, 960 suspected cases of malaria were analyzed using microscopy and RDTs. The sensitivity of the SD Malaria Ag test P.f/Pan® for detection of P. falciparum was 96.8% (95% CI: 90.9-99.3), and 86.0% (95% CI: 78.9-91.5) for the detection of P. vivax. No isolates (95% CI: 0-4.5) lacking either exon of the pfhrp2 gene were identified among the 221 P. falciparum isolates analyzed, but 7.4% (95% CI: 2.8-15.4) lacked the exon 2 part of the pfhrp3 gene. Field isolates lacking either exon of the pfhrp2 gene are absent in this western part of South America. Despite its sensibility to detect P. vivax, the SD Malaria Ag test P.f/Pan® kit is a satisfying alternative to microscopy in remote health centers, where it is difficult to provide highly skilled microscopists and to maintain the necessary equipment.
ISSN: 1932-6203

pasteur-01109596
https://hal-riip.archives-ouvertes.fr/pasteur-01109596
https://hal-riip.archives-ouvertes.fr/pasteur-01109596/document
https://hal-riip.archives-ouvertes.fr/pasteur-01109596/file/journal.pone.0074269.pdf
DOI : 10.1371/journal.pone.0074269

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
TMPRSS2/ERG fusion resulting in ERG overexpression occurs in 30 to 50% of prostate cancer (PCa) in Caucasian patients, but its prognostic relevance remains controversial. In the present study, we investigated ERG expression in all stages of PCa progression, and evaluated the prognostic impact of ERG status in clinically localized PCa (CLC) and in castration resistant disease (CRPC). ERG and AR expressions were evaluated by immunohistochemistry on tissue microarrays containing samples of high grade PIN (n = 57), CLC surgically treated (n = 299, including 185 Caucasians and 114 African-Caribbeans), metastases (n = 17), and CRPC (n = 41). In Caucasians, ERG expression significantly increased from high grade PIN (17.5%) to pT2 (27%) and pT3 CLC (43%), then to metastases (53%). In CLC, stainings for ERG and AR were correlated, and ERG expression was less frequent in African-Caribbeans compared to Caucasians (11.5% vs. 33%). In Caucasians CLC, ERG was associated with longer recurrence free survival, after adjusting for classical prognostic markers. In CRPC, ERG was expressed in 29% of cases, and was associated with a longer overall survival. Our results confirm that ERG expression is less frequent in PCa from patients of African descent. Although ERG expression increases during PCa natural history, positive ERG status is associated with better outcome in both CLC and CRPC. This paradox could be explained in part by the fact that ERG expression is AR dependant, then ERG positive cancers are likely to progress in a rich androgen environment, with a better response to androgen suppression.
ISSN: 0270-4137

hal-01118555
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118555
DOI : 10.1002/pros.22863
PUBMED : 25175352

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
Congenital anomalies are the main causes of preterm and neonatal mortality and morbidity. We investigated the association between congenital anomalies and mothers' exposure to air pollution during pregnancy by combining risk estimates for a variety of air pollutants (SO2, NO2, PM10, PM2.5, CO and O3) and anomaly defect outcomes. Seventeen articles were included in the systematic review and thirteen studies were taken into account in the meta-analysis. Combined estimated were calculated separately according to whether the exposure metric was continuous or categorical. Only one significant combination was; NO2 concentrations were significantly associated with coarctation of the aorta (OR = 1.20 per 10 ppb, 95% CI, (1.02, 1.41)). This finding could stem from strong heterogeneity in study designs. Improved exposure assessment methods, in particular more accurate spatial measurements or modeling, standardized definition of cases and of better control of confounders are highly recommended for future congenital anomalies research in this area.
ISSN: 1660-4601

hal-01118609
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118609
PUBMED : 25089772
DOI : 10.3390/ijerph110807642
PUBMEDCENTRAL : PMC4143824

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Background and Aims: In rain forests, sapling survival is highly dependent on the regulation of trunk slenderness (height/diameter ratio): shade-intolerant species have to grow in height as fast as possible to reach the canopy but also have to withstand mechanical loadings (wind and their own weight) to avoid buckling. Recent studies suggest that mechanosensing is essential to control tree dimensions and stability-related morphogenesis. Differences in species slenderness have been observed among rainforest trees; the present study thus investigates whether species with different slenderness and growth habits exhibit differences in mechanosensitivity. Methods: Recent studies have led to a model of mechanosensing (sum-of-strains model) that predicts a quantitative relationship between the applied sum of longitudinal strains and the plant's responses in the case of a single bending. Saplings of five different neotropical species (Eperua falcata, E. grandiflora, Tachigali melinonii, Symphonia globulifera and Bauhinia guianensis) were subjected to a regimen of controlled mechanical loading phases (bending) alternating with still phases over a period of 2 months. Mechanical loading was controlled in terms of strains and the five species were subjected to the same range of sum of strains. The application of the sum-of-strain model led to a dose-response curve for each species. Dose-response curves were then compared between tested species. Key Results: The model of mechanosensing (sum-of-strain model) applied in the case of multiple bending as long as the bending frequency was low. A comparison of dose-response curves for each species demonstrated differences in the stimulus threshold, suggesting two groups of responses among the species. Interestingly, the liana species B. guianensis exhibited a higher threshold than other Leguminosae species tested. Conclusions: This study provides a conceptual framework to study variability in plant mechanosensing and demonstrated interspecific variability in mechanosensing.
ISSN: 0305-7364

halsde-00454145
https://hal.archives-ouvertes.fr/halsde-00454145
DOI : 10.1093/aob/mcp286

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : The Caribbean has always been viewed as a tourist attraction for pleasure seeking individuals. Over several years, there has been evolved a rather intimate and interactive relationship between visitors and their hosts. The culmination of which is the rather romantic fascination of tourists toward locals in many Caribbean destinations. This is not a new phenomenon, as this pattern is one that evolved at the advent of tourism in the region. Economic and social factors are some of the competing contributors to this phenomenon.It would appear that with the increased influx of tourists in Caribbean destinations, that an astronomical increase in the reported cases of HIV/AIDS and other sexually related transmitted diseases are also witnessed. Trinidad and Tobago (T&T) is amongst the worst exposed in the Caribbean outside of the Dominican Republic and Haiti. Latest reports by the UNAIDS indicates that the number of reported cases in T&T has reached unprecedented levels (over 20,000 in 2009) and continues to increase. This study looks critically at the extent to which tourism and other related leisure activities including carnival, and the cultural diffusion it brings may be contributing to this epidemic. It is also hoped that this study will try to articulate possible suggestions to contain what is increasingly leading to a myriad of cultural, social and economic challenges for the country.
Les Caraïbes ont toujours exercé un attrait touristique sur les personnes en quête de plaisir. Depuis plusieurs années, il a été développé une relation plutôt intime et interactif entre les visiteurs et leurs hôtes dont le point culminant est la fascination plutôt romantique des touristes envers de nombreuses destinations dans les Caraïbes. Il ne s’agit pas d’un phénomène nouveau, ce phénomène repose sur des facteurs économiques et sociaux concurrents. Il convient de s’interroger sur les relations entre que l'afflux croissant de touristes dans ces destinations caribéennes et l'augmentation considérable des cas de VIH/sida et autres maladies sexuellement transmissibles. Trinité-et-Tobago (T & T) est l'une des destinations les plus exposées au sein de la Caraïbe. Les derniers rapports de l'ONUSIDA indiquent que le nombre de cas signalés de T & T a atteint des niveaux sans précédent (plus de 20.000 en 2009) et continue d'augmenter. Cette étude porte un regard critique sur les corrélations établies entre le tourisme et les autres activités de loisirs connexes, comme le carnaval, et la diffusion culturelle pourrait contribuer à cette épidémie. Cette étude vise à articuler des suggestions possibles pour répondre à la myriade de défis culturels, sociaux et économiques) à laquelle est exposé le pays.
Caraïbes
Trinité-et-Tobago

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.5314
http://journals.openedition.org/etudescaribeennes/5314

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Diagnosis of toxoplasmic encephalitis (TE) in patients with AIDS is not straightforward because clinicians rely initially on an empiric diagnosis based on clinical and radiographic improvement to specific anti-Toxoplasma gondii therapy. There is therefore a need for biological tools to improve the diagnosis of TE, especially in tropical areas where this diagnosis is likely to be underestimated. The use of PCR testing in blood samples for the diagnosis of TE has been limited by its poor sensitivity in the studies conducted in Europe. In tropical South America, the results of PCR sensitivity in blood samples were controversial. Considering that T. gondii strains from tropical South America have substantial genetic and pathogenic differences with those from USA and Europe, it is therefore important to re-evaluate the performance of the PCR assay in blood samples for the diagnosis of TE in AIDS patients from this region. Our results showed that the only interest of PCR would be in the most severe forms of TE with altered consciousness because PCR is more likely to be positive. We also provided important genotyping data on T. gondii strains isolated in human cases of toxoplasmosis in the Caribbean and in South America.
ISSN: 1935-2727

hal-01503761
https://hal-unilim.archives-ouvertes.fr/hal-01503761
https://hal-unilim.archives-ouvertes.fr/hal-01503761/document
https://hal-unilim.archives-ouvertes.fr/hal-01503761/file/journal.pntd.0004790.pdf
DOI : 10.1371/journal.pntd.0004790

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
A nested case-control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51-0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07-1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner.
ISSN: 1470-0328

hal-00875955
https://hal.archives-ouvertes.fr/hal-00875955
DOI : 10.1111/j.1471-0528.2012.03400.x
PUBMED : 22676722

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
The seismic behavior of the Himalayan arc between central Nepal and Arunachal Pradesh remains poorly understood due to the lack of observations concerning the timing and size of past major and great earthquakes in Bhutan. We present here the first paleoseismic study along the Himalayan topographic front conducted at two sites in southern central Bhutan. Paleoseismological excavations and related OxCal modeling reveal that Bhutan experienced at least two great earthquakes in the last millennium: one between the seventeenth and eighteenth century and one during medieval times, producing a total cumulative vertical offset greater than 10 m. Along with previous studies that reported similar medieval events in Central Nepal, Sikkim, and Assam, our investigations support the occurrence of either (i) a series of great earthquakes between A.D. 1025 and A.D. 1520 or (ii) a single giant earthquake between A.D. 1090 and A.D. 1145. In the latter case, the surface rupture may have reached a total length of ~800 km and could be associated with an earthquake of magnitude Mw = 8.7–9.1.
ISSN: 0148-0227

hal-01622276
https://hal.archives-ouvertes.fr/hal-01622276
DOI : 10.1002/2015JB012733