Éditeur(s) : HAL CCSD Universites de L'ouest
Résumé : International audience
The agricultural productivism which was decades ago the only prevailing model is now questioned. New perspectives are given to rural development because of the leisure and dweilling functions of the counrtyside.The F.G.R. is intended for the inhabitants professionals, and can promote employment.
Alors que le productivisme agricole qui a prévalu tout au long des décennies précédentes est remis en cause, le développement dans les campagnes des fonctions récréatives et résidentielles donne lieu à une nouvelle réflexion sur l'aménagement rural.Dans ce contexte, le Fonds de Gestion de l'Espace Rural peut constituer un outil original qu s'adresse à la fois aux usagers et aux partenaires de cet espace tout en accordant de nouvelles perspectives de rémunération aux acteurs du monde rural.
ISSN: 0029-182X

hal-01406048
https://hal.univ-antilles.fr/hal-01406048
https://hal.univ-antilles.fr/hal-01406048/document
https://hal.univ-antilles.fr/hal-01406048/file/1998%20Le%20fonds%20de%20gestion%20de%20l%27espace%20rural.pdf

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
BACKGROUND: Chronic HCV infection is associated with the development of hepatic fibrosis. The direct role of HCV in the fibrogenic process is unknown. Specifically, whether HCV is able to infect hepatic stellate cells (HSCs) is debated. OBJECTIVE: To assess whether human HSCs are susceptible to HCV infection. DESIGN: We combined a set of original HCV models, including the infectious genotype 2a JFH1 model (HCVcc), retroviral pseudoparticles expressing the folded HCV genotype 1b envelope glycoproteins (HCVpp) and a subgenomic genotype 1b HCV replicon, and two relevant cellular models, primary human HSCs from different patients and the LX-2 cell line, to assess whether HCV can infect/replicate in HSCs. RESULTS: In contrast with the hepatocyte cell line Huh-7, neither infectious HCVcc nor HCVpp infected primary human HSCs or LX-2 cells. The cellular expression of host cellular factors required for HCV entry was high in Huh-7 cells but low in HSCs and LX-2 cells, with the exception of CD81. Finally, replication of a genotype 2a full-length RNA genome and a genotype 1b subgenomic replicon was impaired in primary human HSCs and LX-2 cells, which expressed low levels of cellular factors known to play a key role in the HCV life-cycle, suggesting that human HSCs are not permissive for HCV replication. CONCLUSIONS: Human HSCs are refractory to HCV infection. Both HCV entry and replication are deficient in these cells, regardless of the HCV genotype and origin of the cells. Thus, HCV infection of HSCs does not play a role in liver fibrosis. These results do not rule out a direct role of HCV infection of hepatocytes in the fibrogenic process.
ISSN: 0017-5749

hal-01063909
https://hal.archives-ouvertes.fr/hal-01063909
DOI : 10.1136/gutjnl-2013-305634
PUBMED : 25063678

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BACKGROUND: Recent studies suggest that a Mediterranean dietary pattern during pregnancy may influence pregnancy outcomes. The aim of this study was to evaluate the effect of adherence to a Mediterranean diet (MD) during pregnancy on fetal growth restriction (FGR) and preterm delivery (PTD) in a French Caribbean island where the population is largely of African descent and presents dietary patterns similar to MD. METHODS: Using data from the TIMOUN Mother-Child Cohort Study conducted in Guadeloupe (French West Indies) between 2004 and 2007, we analysed data for 728 pregnant women who delivered liveborn singletons without any major congenital malformations. Degree of adherence to MD during pregnancy was evaluated with a semi-quantitative food frequency questionnaire based on nine dietary criteria. Multiple logistic regression models were used to analyse birth outcomes while taking potential confounders into account. RESULTS: Overall there was no association between MD adherence during pregnancy and the risk of PTD or FGR. However, pre-pregnancy body mass index was a strong effect modifier, and MD adherence was associated with a decreased risk of PTD specifically in overweight and obese women (adjusted odds ratio 0.7, 95% confidence interval 0.6, 0.9) (P heterogeneity <0.01). CONCLUSIONS: These results suggest that Caribbean diet during pregnancy may carry some benefits of MD and may contribute to reduce the risk of PTD in overweight and obese pregnant women.
ISSN: 0269-5022

hal-00988172
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00988172
DOI : 10.1111/ppe.12113
PUBMED : 24754337

Éditeur(s) : HAL CCSD Oxford University Press (OUP): Policy B1 - Oxford Open Option B Oxford University Press (OUP)
Résumé : International audience
BACKGROUNDA very large proportion of the literature on the endocrine disruptors categorized as anti-androgens deals with phthalates, which are produced in large amounts for use as plastic emollients and additives. In this review, we bring together and analyse work on the effects of phthalates in animals and humans at different stages of their development to assess whether or not their possible anti-androgenic properties represent a significant threat to human health.METHODSThe database PubMed was systematically searched for all English language articles until July 2013 in each subject area discussed.RESULTSWe provide an up-to-date exhaustive, comparative and critical assessment of both in vivo and in vitro studies undertaken to explore the effects of phthalates on the human testis from fetal life to adulthood. These results are compared and discussed in the light of the key data reported in the literature for mice and rats.CONCLUSIONSThe current literature highlights the fact that (i) there is a huge difference between the number of studies performed in animals and in humans, with many fewer for humans; (ii) there are differences in the way rats, mice, primates and humans respond to phthalates, for reasons that need to be further explored; (iii) more work is required to clarify the contradictions, in the few existing human epidemiological studies at all stages of development, which may be partly explained by varying methods of exposure assessment; (iv) in accordance with recent findings in rodents, it cannot be excluded that transgenerational effects of phthalates and/or epigenetic changes exist in humans; (v) a number of methodological limitations need to be solved for the in vitro and xenografting models using human fetal testis to fulfil their 'missing link' role between epidemiological studies in humans and rodent models; and (vi) epidemiological and in vitro studies generally converge sufficiently to conclude that phthalate anti-androgenicity is plausible in adult men.
ISSN: 1355-4786

inserm-00869540
http://www.hal.inserm.fr/inserm-00869540
DOI : 10.1093/humupd/dmt050
PUBMED : 24077978

Éditeur(s) : HAL CCSD
Résumé : International audience
Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a key role in reproduction and exerting functions in numerous nonreproductive tissues. In this review, we attempt to summarize the in vitro studies that are the basis of our current understanding of the mechanisms of action of ERα as a nuclear receptor and the key roles played by its two activation functions (AFs) in its transcriptional activities. We then depict the consequences of the selective inactivation of these AFs in mouse models, focusing on the prominent roles played by ERα in the reproductive tract and in the vascular system. Evidence has accumulated over the two last decades that ERα is also associated with the plasma membrane and activates non-nuclear signaling from this site. These rapid/nongenomic/membrane-initiated steroid signals (MISS) have been characterized in a variety of cell lines, and in particular in endothelial cells. The development of selective pharmacological tools that specifically activate MISS and the generation of mice expressing an ERα protein impeded for membrane localization have begun to unravel the physiological role of MISS in vivo. Finally, we discuss novel perspectives for the design of tissue-selective ER modulators based on the integration of the physiological and pathophysiological roles of MISS actions of estrogens.
Physiological Reviews

hal-01533249
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01533249
DOI : 10.1152/physrev.00024.2016
PUBMED : 28539435

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
The number and amount of man-made chemicals present in the aquatic environment has increased considerably over the past 50 years. Among these contaminants, endocrine-disrupting chemicals (EDCs) represent a significant proportion. This family of compounds interferes with normal hormonal processes through multiple molecular pathways. They represent a potential risk for human and wildlife as they are suspected to be involved in the development of diseases including, but not limited to, reprotoxicity, metabolic disorders, and cancers. More precisely, several studies have suggested that the increase of breast cancers in industrialized countries is linked to exposure to EDCs, particularly estrogen-like compounds. Estrogen receptors alpha (ERα) and beta (ERβ) are the two main transducers of estrogen action and therefore important targets for these estrogen-like endocrine disrupters. More than 70% of human breast cancers are ERα-positive and estrogen-dependent, and their development and growth are not only influenced by endogenous estrogens but also likely by environmental estrogen-like endocrine disrupters. It is, therefore, of major importance to characterize the potential estrogenic activity from contaminated surface water and identify the molecules responsible for the hormonal effects. This information will help us understand how environmental contaminants can potentially impact the development of breast cancer and allow us to fix a maximal limit to the concentration of estrogen-like compounds that should be found in the environment. The aim of this review is to provide an overview of emerging estrogen-like compounds in the environment, sum up studies demonstrating their direct or indirect interactions with ERs, and link their presence to the development of breast cancer. Finally, we emphasize the use of in vitro and in vivo methods based on the zebrafish model to identify and characterize environmental estrogens.
ISSN: 2073-4425

hal-01616486
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616486
DOI : 10.3390/genes8090229
PUBMED : 28914763
PUBMEDCENTRAL : PMC5615362

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999
Résumé : Since the early 1980's, the Secretariat of the Pacific Community (SPC, formerly the South Pacific Commission) has contributed to the development of FAD programmes for the artisanal fisheries sector in the Pacific region. In particular, it has put considerable efforts into developing technology that would assure a two-year average FAD lifespan, while maintaining costs under US$ 4,000 per FAD unit. From 1996 to 1998, this work led to the publication of three volumes of the SPC FAD Manual. Volume 2 of this manual, "Rigging Deep-Water FAD Moorings", describes in great detail two FAD models that were developed from the original 1983 SPC-recommended model, and gives precise instructions on the way to construct them. Despite SPC's work, the objectives set, in particular the two-year average lifespan for FADs, have not been consistently met, resulting in many FAD programmes in the region being suspended. An analysis of the reasons why this has occurred is presented, along with a short description of the practical research that could be pursued, using different objectives, to introduce new FAD programmes in the region.Original Abstract: Depuis le debut des annees quatre-vingt, le secretariat general de la communaute du Pacifique (SPC, anciennement commission du Pacifique Sud) a soutenu et accompagne le developpement de programmes DCP destines au secteur de la peche artisanale, dans la region Pacifique. Il s'est en particulier efforce de mettre au point des modeles de DCP repondant principalement aux deux criteres suivants: duree de vie superieure a deux ans et cout unitaire moyen inferieur a 4 000 dollars US. Entre 1996 et 1998, ces travaux ont abouti a la publication en trois volumes du manuel de la SPC sur les DCP. Le volume 2 de ce manuel, " La fabrication de DCP pour grandes profondeurs ", presente deux evolutions d'un modele concu en 1983 et en detaille tres precisement les methodes de fabrication. Le present document analyse les raisons pour lesquelles, malgre les efforts deployes, les objectifs fixes, et en particulier la duree de vie minimum de deux ans pour les DCP, n'ont pas ete pleinement atteints et la plupart des programmes DCP de la region ont ete interrompus. Il donne egalement une breve description des axes de recherche appliquee qui pourraient etre suivis, en se fixant d'autres objectifs, pour relancer des programmes DCP dans la region.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00042/15291/12648.pdf
http://archimer.ifremer.fr/doc/00042/15291/

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
We use lithospheric-scale analog models to study the reactivation of pre-existing heterogeneities under oblique shortening and its relation to the origin of arcuate orogens. Reactivation of inherited rheological heterogeneities is an important mechanism for localization of deformation in compressional settings and consequent initiation of contractional structures during orogenesis. However, the presence of an inherited heterogeneity in the lithosphere is in itself not sufficient for its reactivation once the continental lithosphere is shortened. The heterogeneity orientation is important in determining if reactivation occurs and to which extent. This study aims at giving insights on this process by means of analog experiments in which a linear lithospheric heterogeneity trends with various angles to the shortening direction. In particular, the key parameter investigated is the orientation (angle α) of a strong domain (SD) with respect to the shortening direction. Experimental results show that angles α ≥ 75° (high obliquity) allow for reactivation along the entire SD and the development of a linear orogen. For α ≤ 60° (low obliquity) the models are characterized by the development of an arcuate orogen, with the SD remaining partially non-reactivated. These results provide a new mechanism for the origin of some arcuate orogens, in which orocline formation was not driven by indentation or subduction processes, but by oblique shortening of inherited heterogeneities, as exemplified by the Ouachita orogen of the southern U.S.
ISSN: 0278-7407

insu-01498544
https://hal-insu.archives-ouvertes.fr/insu-01498544
https://hal-insu.archives-ouvertes.fr/insu-01498544/document
https://hal-insu.archives-ouvertes.fr/insu-01498544/file/Calignano_et_al-2017-Tectonics.pdf
DOI : 10.1002/2016TC004424

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
An exploration 3D seismic data set from the Gjallar Ridge off mid-Norway images a giant fluid seep structure 3 × 5 km wide, which connects to late Palaeocene magmatic sills at depth. Two of the pipes that have developed as hydrothermal vents reach all the way to the modern seafloor implying that they either were active much longer than the original hydrothermal activity or have been reactivated. We combine detailed seismic analysis of the northern pipe and sandbox modeling to constrain pipe initiation and propagation. Although both the seismic data and the sandbox models suggest that fluids at depth are focused through a vertical conduit, sandbox models show that fluids ascend and reach a critical depth migration where focused migration abruptly transforms into distributed fluid flow through unconsolidated sediments. This indicates that at this level the sediments are intensely deformed during pipe propagation, creating a V-shaped structure, i.e. an inverted cone at depth and a positive relief anomaly, 5 to 10 m high, at the seafloor, which is clearly identified on 3D seismic data. Comparison of the geometries observed in sandbox modeling with the seismically observed geometries of the Giant Gjallar Vent suggests that the Giant Gjallar Vent may be a proto-fluid seep at an early stage of its development, preceding the future collapse of the structure forming a seafloor depression. Our results imply that the Gjallar Giant Vent can be used as a window into the geological processes active in the deep parts of the Vøring Basin.
ISSN: 0025-3227

hal-00772465
https://hal.archives-ouvertes.fr/hal-00772465
DOI : 10.1016/j.margeo.2012.08.010

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : L’image idyllique du tourisme de luxe dans certains territoires de la Caraïbe, de l’océan Indien et du Pacifique fait souvent rêver et attire depuis longtemps une clientèle fortunée. Pour autant, les dépenses effectuées sur place par cette clientèle induisent-elles véritablement des retombées positives sur la croissance et le développement économique de ces territoires, sur le niveau de vie de la population, contribue-t-il à combattre le chômage et à réduire la pauvreté ? Quels en sont les impacts au plan environnemental et humain ? En deux mots, les principes du développement durable trouvent-ils sur place un terrain d’application favorable et conforme à ce concept ? Pour y répondre, Anguilla, petite destination touristique de luxe de la Caraïbe, fréquentée majoritairement par une clientèle de séjour en provenance des États-Unis est utilisée comme étude de cas. Aussi, cette étude a pour but d’analyser les relations complexes entre le tourisme et la problématique du développement local dans ce microterritoire, en se fixant deux objectifs : en premier lieu, voir si l’hypothèse de la croissance tirée par le tourisme est une option concevable dans cette petite destination touristique. En second lieu, vérifier si l’activité touristique exerce un impact positif sur le développement économique inclusif d’Anguilla, par sa capacité ou non à stimuler les autres secteurs d’activité. À cet effet, deux modèles de régression employés dans un cadre de cointégration sont utilisés successivement. D’une part, les résultats montrent qu’un accroissement de 1 % de la recette touristique à Anguilla se traduit à long terme par une augmentation de 0,6 % de son PIB, confirmant ainsi l’hypothèse de la croissance tirée par le tourisme. De plus, les tests de causalité de Granger révèlent l’existence d’une causalité bidirectionnelle entre activité touristique et croissance économique. D’autre part, ces résultats montrent que la croissance du secteur touristique s’accompagne par une contraction de l’activité agricole à Anguilla, engendrant de ce fait une perte de ressources pour le pays, ainsi qu’un accroissement de « fuites » liées aux importations dérivées. En conséquence, le potentiel du tourisme en tant que facteur de développement inclusif devient une hypothèse irrecevable dans ce petit territoire, et ce, en raison des effets multiplicateurs et de liaison limités sur les producteurs locaux.
The romantic image of luxury tourism in Caribbean, Indian Ocean, and pacific islands make you often dream and attracts for many years a high profile customer. Would the expenses incurred by the visitors lead to a positive impacts on economic growth? What are the impacts on environment and human aspects? Briefly, does the principles of sustainable and inclusive development a concept applicable in these islands? Anguilla, a small luxury island in the Caribbean area is used as case study. The purpose of this study is to determine the role of tourism in the economy of Anguilla. More specifically, this investigation attempts to verify the presence of the tourism-led growth hypothesis (TLGH) in the case of Anguilla, also to explore the nature of the linkage between the tourism sector and the agriculture, manufacturing and other service industries in the long-run and the short-run. In so doing, two regression models are used in a cointegration framework. The long-run relation indicates that a 1% change in tourism revenues in Anguilla would lead to a 0.6% increase in real GDP in the long-run, ceteris paribus. Our findings have also empirically verified the presence of the tourism-led growth hypothesis. However, the application of the error-correction methodology, produced results which suggested that the agriculture sector has contracted as the tourism sector expanded. In conclusion, the economic growth in Anguilla is positively affected by growth in the tourism sector as the latter sector loses resources to the expanding sector.
Anguilla
Caraïbes

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.7409
http://journals.openedition.org/etudescaribeennes/7409

Éditeur(s) : HAL CCSD
Résumé : Dans le cadre d'un renouveau de la défense des races locales, cet article analyse les schémas de pensées et les projets collectifs autour du cabri Créole aux Antilles où existent simultanément deux modèles de développement, l'élevage « traditionnel » et l'élevage « moderne ». Le premier utilise la race locale, la Créole et des systèmes d'élevage traditionnels comme l'attache au piquet; il a été souvent appelé à disparaître mais en réalité, il présente une réelle capacité de résistance et d'adaptation. L'élevage moderne à base de races exotiques importées utilise des systèmes d'élevage de type intensif qui s'inspirent des modèles européens et qui ont été soutenus par la politique du gouvernement ; c'est donc le modèle dominant. De ce fait, la filière caprine en Guadeloupe voit cohabiter des exploitations de polyculture-élevage souvent valorisant des zones difficiles et des grosses structures d'élevage qui se spécialisent en production de viande caprine semi-intensive. On assiste actuellement au paradoxe où un type racial viande (génotypes à base de sang Boer ou autres croisements viande) devient dominant au détriment de la race locale. Or la race Créole gagnerait à être soutenue en raison de sa résistance et son adaptation au milieu. Mais sur cette question, l'aspect strictement technique est dépassé par le débat sociétal avec ses dimensions historiques, humaines et culturelles. Toutefois en Guadeloupe, il n'y a pas de vision collective unanime pour soutenir la race locale, ce qui est dû a des intérêts divergents et une difficulté de mise en cohérence de l'ensemble du projet. Ainsi, l'une des questions principales qui se posent est : comment infléchir les pratiques des éleveurs pour qu'ils s'approprient leur race locale qui est un élément d'ancrage au territoire, au savoir-faire et à la culture antillaise ? La démarche d'une production d'un cabri Créole AOC permettrait de relier la race locale au terroir en favorisant l'identité locale amenée à être portée par les acteurs territoriaux. Donc pour aboutir à un véritable modèle de développement à l'avenir, il conviendrait de mettre en place un véritable processus d'appropriation de la race locale dans son territoire.
ISSN: 0397-6572

hal-01600973
https://hal.archives-ouvertes.fr/hal-01600973
PRODINRA : 397825

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The extinct Odontopterygiformes are the sole birds known to possess strong and sharp bony pseudoteeth, the shape and location of which are closely mimetic of real teeth. The structure of the pseudoteeth is investigated here in a late Pliocene/early Pleistocene species, Pelagornis mauretanicus, using X-ray microtomography and thin sections. The results are interpreted with regard to the pseudotooth mode of growth, and have implications concerning aspects of Pelagornis ecology. The larger pseudoteeth are hollow and approximately cone-shaped, and the smaller ones are rostro-caudally constricted. The walls of pseudoteeth are composed of bone tissue of the fibro-lamellar type, which is intensively remodeled by Haversian substitution. The jaw bones display the same structure as the pseudoteeth, but their vascular canals are oriented parallel to the long axis of the bones, whereas they are perpendicular to this direction in the pseudoteeth. There is no hiatus or evidence of a fusion between the pseudoteeth and the jaw bones. Two possible models for pseudotooth growth are derived from the histological data. The most plausible model is that pseudotooth growth began after the completion of jaw bone growth, as a simple local protraction of periosteal osteogenic activity. Pseudotooth development thus occurred relatively late during ontogeny. The highly vascularized structure and the relative abundance of parallel-fibered bone tissue in the pseudoteeth suggest poor mechanical capabilities. The pseudoteeth were most likely covered and protected by the hardened, keratinized rhamphotheca in the adult during life. The late development of the pseudoteeth would involve a similarly late and/or partial hardening of the rhamphotheca, as displayed by extant Anseriformes, Apterygiformes and some Charadriiformes. This would add support to the hypothesis of a close phylogenetic relationship between Odontopterygiformes and Anseriformes. The late maturation of the Pelagornis feeding apparatus, and hence the delayed capability for efficient prey catching, suggests that Pelagornis was altricial.
ISSN: 1932-6203

hal-01545486
https://hal.archives-ouvertes.fr/hal-01545486
DOI : 10.1371/journal.pone.0080372

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Saccharomyces cerevisiae is an established model organism for the molecular analysis of fundamental biological processes. The genomes of numerous strains have been sequenced, and the transcriptome and proteome ofmajor phases during the haploid and diploid yeast life cycle have been determined. However, much less is known about dynamic changes of the proteome when cells switch from mitotic growth to meiotic development. We report a quantitative protein profiling analysis of yeast cell division and differentiation based on mass spectrometry. Information about protein levels was integrated with strand-specific tiling array expression data. We identified a total of 2366 proteins in at least one condition, including 175 proteins showing a statistically significant > 5-fold change across the sample set, and 136 proteins detectable in sporulating but not respiring cells. We correlate protein expression patterns with biological processes and molecular function by Gene Ontology term enrichment, chemoprofiling, transcription interference and the formation of double stranded RNAs by overlapping sense/antisense transcripts. Our work provides initial quantitative insight into protein expression in diploid respiring and differentiating yeast cells. Critically, it associates developmentally regulated induction of antisense long noncoding RNAs and double stranded RNAs with fluctuating protein concentrations during growth and development.
ISSN: 1874-3919

hal-01485858
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01485858
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01485858/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01485858/file/Becker%20et%20al.%20-%20The%20protein%20expression%20landscape%20of%20mitosis%20and%20me.pdf
DOI : 10.1016/j.jprot.2016.12.016

Éditeur(s) : HAL CCSD American Society for Biochemistry and Molecular Biology
Résumé : International audience
alpha- and beta-spectrins are components of molecular scaffolds located under the lipid bilayer and named membrane skeletons. Disruption of these scaffolds through mutations in spectrins demonstrated that they are involved in the membrane localization or the maintenance of proteins associated with them. The ubiquitous alphaII-spectrin chain bears in its central region a unique domain that is sensitive to several proteases such as calpains or caspases. The conservation of this region in vertebrates suggests that the proteolysis of alphaII-spectrin by these enzymes could be involved in important functions. To assess the role of alphaII-spectrin cleavage in vivo, we generated a murine model in which the exons encoding the region defining this cleavage sensitivity were disrupted by gene targeting. Surprisingly, homozygous mice expressing this mutant alphaII-spectrin appeared healthy, bred normally, and had no histological anomaly. Remarkably, the mutant alphaII-spectrin assembles correctly into the membrane skeleton, thus challenging the notion that this region is required for the stable biogenesis of the membrane skeleton in nonerythroid cells. Our finding also argues against a critical role of this particular alphaII-spectrin cleavage in either major cellular functions or in normal development.
ISSN: 0021-9258

inserm-00284621
http://www.hal.inserm.fr/inserm-00284621
http://www.hal.inserm.fr/inserm-00284621/document
http://www.hal.inserm.fr/inserm-00284621/file/Meary_-_JBC_2007.pdf
PUBMED : 17374614

Éditeur(s) : Littoral 2004, Aberdeen, Scotland, UK, September 2004
Résumé : NAMIBIE (a french acronym for Integrated Multimedia Navigator Within Coastal Environment Data Bases) is a specific tool which first concept has been established by Ifremer and has been developped by an association between research in the field of coastal environment, innovation in the field of new information and communication technologies and services in the field of coastal integrated management and impact studies. The objectives of this tool are to facilitate research, direct access and display of relevant multimedia coastal integrated data and information according to an interactive, widely opened and playfull interface. The principles are based upon the fact that sustainable decision making needs an optimized unterstanding of coastal processes and better consultation between actors. In this purpose the development of the tool has considered that the end-user should and could be free to look after the data and the information he needs for a particular site or environment of interest and for a specific ICZM question according to easy navigation interfaces. That is why NAMIBIE concept is based upon : - a coherent 3D representation of the coasts (i.e. from catchement areas to continental shelf and deep sea), which considers a coherent DEM from land to sea and textural representation of the environment using satellite imagery textural displays, - a 3D navigator which allows the user to fly or dive over and within the coastal environment of interest, - a multimedia database (text, graphs, image, maps, geographic objects, modelling results...) specific to the territory of interest, - an interactive interface which helps in finding relevant information associated to specific questions. The technologies used include VRML data format, integration of standard GIS format (shp, grid, img) within the navigator, integration and display of modelling data. The production chain is realized in C++ and Java scripts allow dialogue between web pages and 3D windows. Applications are presented on the coasts of Languedoc Roussillon region (French Mediterranean border) in the framework of ICZM problematics

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00089/20055/17696.pdf
http://archimer.ifremer.fr/doc/00089/20055/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Maternal affective disorders are frequently treated with selective serotonin reuptake inhibitor medications (SSRIs); with up to 10% of women being prescribed these medications during pregnancy. Infant development depends on the early serotonergic environment, which is altered by perinatal SSRIs, raising concern about how these medications affect neural outcomes. While clinical and preclinical research suggests an impact of SSRIs on the developing brain, more research is needed to determine the effects on neuroplasticity, the serotonergic system, and the hypothalamic-pituitary-adrenal axis in neural regions mediating behavior. The current work investigated the effects of the SSRI, fluoxetine, on the serotonergic system in the prefrontal cortex (PFC) during pre-adolescence, and changes to synaptic markers and glucocorticoid receptor density in the cingulate cortex (medial PFC) of pre-adolescent and adult Sprague-Dawley male and female rats. To model aspects of Perinatal Depression and maternal anxiety, pre-gestational maternal stress was used resulting in male and female offspring from 4 groups: 1) control, 2) perinatal fluoxetine exposed, 3) pre-gestational maternal stress exposed, and 4) pre-gestational maternal stress + fluoxetine. Perinatal fluoxetine prevented the effects of maternal stress on 5-HT levels and 5-HT turnover ratio in the PFC of pre-adolescent offspring, particularly in females. However, pre-gestational stress reduced synaptophysin and PSD-95 densities in the cingulate cortex, effects that were more pronounced in males. Interestingly, perinatal fluoxetine exposure reduced GR density in adult males in this same brain area. Together, results show differential effects of perinatal SSRIs and pre-gestational maternal stress on neurodevelopment in the PFC of males and females.
ISSN: 0028-3908

hal-01647158
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647158
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647158/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647158/file/Gemmel%20-%20Perinatal%20fluoxetine%20prevents%20the%20effect.pdf
DOI : 10.1016/j.neuropharm.2017.10.009

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Les îles sont devenues les principaux marchés mondiaux pour le tourisme balnéaire en profitant de leur richesse naturelle et culturelle. Dans le même temps, les îles sont des territoires fragiles avec des ressources limitées, raison pour laquelle un développement durable de l’activité touristique est une nécessité. L'étude de la consommation des ressources naturelles par le tourisme est une étape essentielle pour détecter les menaces que cette activité cause à l'environnement et donc la mise en œuvre de mesures plus durables. Dans cet article, nous analysons la consommation des ressources naturelles dans cinq régions touristiques de Minorque. Les données ont été recueillies auprès des fournisseurs, des établissements touristiques et au travail d’enquête terrain, ainsi cela nous a permis d'estimer la consommation d'eau et d'électricité, la production et la collecte des déchets pour les études de cas. Les consommations élevées d’eau et de déchets observés indiquent la nécessité d'entreprendre des actions. D'autre part, les résultats montrent que les coûts environnementaux les plus élevés proviennent des établissements touristiques fondés sur la faible densité de ménage.
Islands have become world’s leading markets for sun and sand tourism taking advantage of their natural and cultural richness. At the same time, islands are fragile territories with limited resources, reason why a sustainable development of tourism is a necessity. The study of natural resources consumption by tourism is an essential step to detect the threats that this activity is causing to the environment and thus implement measures to go towards a more sustainable direction. In this article we analyze the natural resources consumption in five tourist areas of Menorca. Data were gathered from supplier companies, tourist establishments and through fieldwork, and allowed us to estimate water and electricity consumption, generation and collection of waste for the case studies. The high observed ratios of water consumption as well as waste generation and collection ratios indicate the need to undertake actions. The results showed the higher environmental costs of tourism settlements based on low density of household.
Espagne
Minorque

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.6267
http://journals.openedition.org/etudescaribeennes/6267

Éditeur(s) : Université de Bucarest - Université de Bretagne occidentale
Résumé : This study is focusing on the architecture and recent sedimentary evolution of the Danube channel, the youngest channel-levee system in the Danube deep-sea fan. The study was conducted as part of the BlaSON French-Romanian Project, and combined high-resolution seismic-reflection profiles and chirp profiles with multibeam bathymetry and piston cores. This data set was acquired in 1998 during a joint survey IFREMER-GeoEcoMar of the north-western Black Sea. Previous seismic and acoustic data were also used. The Danube deep-sea fan is a large passive-margin mud-rich fan. Like the other systems of this type (Amazon fan, Mississippi fan or Indus fan) the Danube fan consists of stacked channel-levee systems intercalated with mass-transport deposits. Seismic and sedimentary facies in the Danube fan are similar to those identified in most of the mud-rich systems. Nevertheless, the Danube fan is distinguished by a specific feature: its development in a freshwater environment. This is due to the peculiar water-level history of the Black Sea controlled by the link to the Mediterranean through the Strait of Bosphorus and the Sea of Marmara. This connexion was successively interrupted (during sea level lowstands) and re-established (when the sea level was rising above the Bosphorus). Temporary absence of marine water influx during lowstands together with large freshwater inputs from the Danube and other major rivers changed the Black Sea into a freshwater lake during times of fan activity. This peculiarity possibly favourised the development of hyperpycnal flow at the Danube mouth and the initiation of turbidity currents in the deep-sea fan. The Danube channel is directly connected to the large shelf-indenting Danube canyon (also known as Viteaz canyon). The Danube canyon is deeply incised into the shelf margin for 26 km landward of the shelfbreak. During lowstands this canyon acted as the most important path for sediment supply to the deep sea in this part of the continental margin. It consists of a main trough with steep flanks, and a meandering thalweg cut into the flat canyon floor, attesting for the development of the canyon by erosion in the entrenched axial thalweg. Sections with specific morphology, orientation and gradient identified along the canyon, are interpreted as phases of landward expansion of the canyon. Internal structure of the canyon shows several erosional surfaces, which indicate that the present morphology of the canyon is the result of its polyphasic evolution. Instability in the zone of the canyon is related to the important sediment supply at the Danube mouth, to the presence of the gas in the surficial sediment, and possibly under a structural control. The upper part of the Danube channel (between the Danube canyon and ~1400 m depth) consists in a single leveed-channel that has undergone significant overbank deposition, as attested by the well-developed levees. The levees are strongly asymmetrical, being higher and wider on the right-hand side looking downstream. This type of asymmetry is rather common in deep-sea fans, and is generally attributed to the Coriolis effect (Menard, 1955). The channel is slightly sinuous, partially filled and incised by an entrenched thalweg, connected to the axial thalweg of the Danube canyon. Detailed seismic investigation inside the channel trough documented several depositional phases within the channel fill, separated by erosional surfaces. These surfaces are associated with distinct terraces identified on the multibeam bathymetry, that can be followed downward along the main trough axis. The valley fill deposits (where not removed by the subsequent erosional event) show an axial HAR (High Amplitude Reflections) seismic facies with lateral lower amplitude continuous reflections consisting in a levee facies, as proved by sampling. This indicates that filling up was associated with flow within the channel, and not with interruption of fan activity. On the middle slope below 1400 m, this single channel bifurcates through repeated avulsions. As a result, several highly meandering channels developed. The onlap relationships between these channels indicate that only one channel was active at a time. Each phase of avulsion resulted in a depositional unit consisting in a basal unchannelized lobe defined as High Amplitude Reflection Packets (HARP, Flood et al., 1991) that underlies a channel-levee system. The deposition of HARPs was associated with the readjustment of the longitudinal profile of the channel after the breaching of a levee, which resulted in remobilization of upslope channel deposits and eroded levees. When this adjustment was complete, erosion ceased and levees began to develop above the HARPs (Pirmez et al., 1997). All the identified phases of avulsion followed the same pattern: (1) breaching of the lower and narrower left levee; (2) building of a unit of High Amplitude Reflector Packets (HARP) basinward of the bifurcation point by the unchannelized flow, while the former channel was abandoned; and (3) initiation of a new meandering leveed channel. The northward migration of the resulting units through repeated bifurcations is influenced by the asymmetry between levees (hence by the Coriolis effect), and confined between the high levees of the initial phase of the Danube channel (to the south) and the steep relief of the Dniepr fan (to the north). Structure of the fan valley fill indicate that the erosional surfaces inside the upper channel could be formed in response of successive avulsions, by the adjustment of the longitudinal profile of the channel following the breaching of a levee wall. Sediments removed by erosion formed the HARP lobes basinward of the avulsion point. When this adjustment was complete, a channel-levee system developed downward of the bifurcation, overlying the HARPs, but also upward of this point, as a confined channel-levee system inside the erosional trough of the fan valley. Fluvial incisions identified on the continental shelf, together with the coastline location during the last active period of the Danube channel, indicated that the paleo-Danube was directed towards the head of the Danube canyon. Paleo-Danube mouth was fairly close (ca. 10 km) to the Danube canyon, supplying sediment to the Danube channel. Furthermore, hyperpycnal flow probably prevailed in the freshwater environment that characterized the Black Sea during times of fan activity. These conditions would have enabled the development of a quasi-continuous river-canyon-deep-sea fan system, ensuring the effective transfer of the sediment between the coastal zone and the deep sea.
Ce travail est consacré à l'étude de l'architecture et de l'évolution sédimentaire récente de l'éventail profond du Danube, en particulier de son dernier système chenal-levée: le chenal du Danube. L'étude a été réalisée dans le cadre du projet de coopération franco-roumaine BlaSON, à partir des données sismiques, bathymétriques-acoustiques et sédimentologiques acquises en 1998 lors d'une campagne en mer Noire réalisée par IFREMER et GeoEcoMar. Des données sismiques et acoustiques antérieures ont été également utilisées. L'éventail profond du Danube s'enserre dans la catégorie des grands éventails vaseux. Comme les autres systèmes de ce genre (tel que les éventails de l'Amazone, du Mississippi ou de l'Indus) il est constitué d'une succession de systèmes chenaux-levées intercalés avec des dépôts de transport en masse. Le fonctionnement de l'éventail était conditionné par la baisse du niveau marin lors des périodes glaciaires. Ses faciès sismiques et sédimentaires s'apparentent aux faciès qui caractérisent la plupart des éventails de ce type. L'éventail du Danube constitue néanmoins un cas particulier parmi les autres systèmes étudiés, du fait de son fonctionnement dans un bassin lacustre. Ceci est dû à la situation spécifique de la mer Noire dont la connexion avec la Méditerranée, par le détroit de Bosphore et la mer de Marmara, a été successivement interrompue (au cours de périodes de bas niveau) et reprise (quand le niveau marin remontait en dépassant le seuil du Bosphore). L'absence de l'apport d'eau salée pendant les périodes glaciaires, associée avec l'augmentation de l'apport fluvial, ont déterminé l'installation d'un milieu d'eau douce dans la mer Noire à chaque fois que la baisse du niveau permettait la reprise du fonctionnement de l'éventail profond. Cette situation particulière aurait favorisé la formation des courants hyperpycnaux à l'embouchure d'un fleuve du débit du Danube qui déversait ses eaux turbides dans un bassin lacustre, et aurait donc influencé l'apparition de courants de turbidité dans l'éventail profond. Le chenal du Danube s'est développé sur la pente continentale en prolongation du canyon du Danube (ou Viteaz) auquel il est directement connecté. Le canyon est incisé de manière significative (26 km) dans la plate-forme continentale. Au cours de bas-niveaux marins il constituait la principale voie de transfert des sédiments terrigènes vers le bassin profond dans cette partie de la marge. Le canyon est constitué par une entaille avec des flancs abrupts et un talweg axial incisé, qui montre l'importance du processus d'érosion du fond pour le développement du canyon. Les segments qui ont été identifiés le long du canyon, avec des morphologies, des orientations et des pentes spécifiques, sont interprétés comme des phases d'avancement du canyon vers la côte. Plusieurs incisions sont visibles dans la structure interne du canyon et témoignent que la morphologie actuelle du canyon est le résultat de son évolution polyphasée. L'instabilité de la zone du canyon est en relation avec les apports sédimentaires importants à l'embouchure du Danube, avec la présence du gaz dans les sédiments superficiels, et possiblement sous un contrôle structural. Sur la pente supérieure (entre le canyon du Danube et environ 1400 m de profondeur) le chenal du Danube présente des levées bien développées et fortement asymétriques, avec la levée droite plus haute et plus large que la levée gauche. Ce type d'asymétrie, fréquemment décrit dans les éventails profonds est généralement attribué à l'effet Coriolis (Menard, 1955). Le chenal est légèrement sinueux, partiellement comblé et incisé par un talweg axial qui représente la continuation sur la pente du talweg incisé dans le canyon du Danube. L'analyse sismique détaillée du remplissage de la vallée montre plusieurs phases de dépôt, séparées par des discontinuités érosives. Ces surfaces d'érosion correspondent à des terrasses emboîtées, relativement parallèles le long de la vallée, visibles dans la bathymétrie. Les dépôts qui constituent le remplissage du chenal présentent un faciès sismique de type HAR (High Amplitude Reflections) dans l'axe du chenal, partiellement (ou parfois totalement) enlevé par les phases d'érosion subséquentes, qui continue latéralement avec des réflexions litées correspondant à un faciès sédimentaire de levée. Le remplissage de la vallée a été donc associé avec des écoulements dans le chenal, et non pas avec l'interruption de son fonctionnement. Sur la pente inférieure, le chenal unique bifurque plusieurs fois par avulsion et forme de nouveaux systèmes chenaux-levées méandriformes. Ces systèmes se succèdent verticalement en onlap, ce qui montre qu'un seul chenal a été actif à la fois. Chaque phase d'avulsion a eu comme résultat la mise en place d'une unité constituée par un lobe défini comme "High Amplitude Reflection Packets" (HARP, Flood et al., 1991) à la base, et un système chenal-levée au sommet. Le dépôt d'un lobe HARP est associé avec de l'érosion dans le chenal en amont du point d'avulsion pour l'ajustement de son profil après la rupture de la levée. Quand le chenal a retrouvé son profil d'équilibre, l'érosion a cessé et des levées ont commencé à se développer au-dessus des HARPs (Pirmez et al., 1997). Toutes les phases d'avulsion se sont développées d'après le même modèle: (1) la rupture de la levée gauche, plus étroite; (2) le dépôt d'un lobe HARP par les écoulements non-chenalisés en aval du point d'avulsion, et l'abandon de l'ancien chenal; (3) l'initiation d'un nouveau système chenal-levée. La migration systématique du chenal vers le nord est influencée par l'assymétrie des levées (donc par la force de Coriolis), et confinée entre les grandes levées de la phase initiale du chenal du Danube, au sud, et le relief abrupt de l'éventail du Dniepr au nord. La structure sédimentaire du chenal du Danube indique que les surfaces érosives à l'intérieur du remplissage du chenal se seraient formées en réponse aux avulsions, du fait de l'ajustement du profil du chenal après la rupture d'une levée. Les sédiments du chenal érodés au cours de ce processus ont formé les lobes HARP. Quand le chenal a retrouvé son profil d'équilibre, un système chenal-levée s'est développé en aval du point d'avulsion au dessus du lobe HARP, mais aussi en amont de ce point, où il se trouve confiné dans la vallée érosive. Les incisions fluviatiles identifiés sur la plate-forme continentale et la position de la ligne de côte pendant la dernière période d'activité du chenal du Danube montrent que le paléo-Danube se dirigeait directement vers la tête du canyon du Danube. Son embouchure était située à proximité du canyon, qui alimentait le chenal du Danube. Cependant, les courants hyperpycnaux devaient prévaloir dans le milieu de salinité réduite qui caractérisait la mer Noire lors des périodes actives de l'éventail. Ces conditions auraient favorisé la mise en place d'un système quasi-continu fleuve-canyon-éventail profond, qui contrôlait le transfert des sédiments entre la côte et le bassin profond.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2002/these-1206.pdf
http://archimer.ifremer.fr/doc/00000/1206/

Éditeur(s) : HAL CCSD Endocrine Society
Résumé : International audience
The Developmental Origins of Health and Disease (DOHaD) paradigm is one of the most rapidly expanding areas of biomedical research. Environmental stressors that can impact on DOHaD encompass a variety of environmental and occupational hazards as well as deficiency and oversupply of nutrients and energy. They can disrupt early developmental processes and lead to increased susceptibility to disease/dysfunctions later in life. Presentations at the fourth Conference on Prenatal Programming and Toxicity in Boston, in October 2014, provided important insights and led to new recommendations for research and public health action. The conference highlighted vulnerable exposure windows that can occur as early as the preconception period and epigenetics as a major mechanism than can lead to disadvantageous "reprogramming" of the genome, thereby potentially resulting in transgenerational effects. Stem cells can also be targets of environmental stressors, thus paving another way for effects that may last a lifetime. Current testing paradigms do not allow proper characterization of risk factors and their interactions. Thus, relevant exposure levels and combinations for testing must be identified from human exposure situations and outcome assessments. Testing of potential underpinning mechanisms and biomarker development require laboratory animal models and in vitro approaches. Only few large-scale birth cohorts exist, and collaboration between birth cohorts on a global scale should be facilitated. DOHaD-based research has a crucial role in establishing factors leading to detrimental outcomes and developing early preventative/remediation strategies to combat these risks
ISSN: 0013-7227

hal-01187409
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01187409
DOI : 10.1210/EN.2015-1350
PUBMED : 26241067

Résumé : La valorisation du patrimoine culturel, matériel et immatériel, trouve sa justification en tant que vecteur de différenciation, dans un contexte où le seul modèle touristique de type fordiste ne fait plus recette. Ce patrimoine dans lequel l’homme place du subjectif, des référents culturels et affectifs, voire même des symboles, serait donc à considérer comme une ressource, un vecteur de distinction des territoires, tant il est pourvoyeur d’authenticité. Ainsi, lorsqu’il joue un rôle de marqueur identitaire, le patrimoine peut-être mobilisé par les acteurs impliqués dans le développement local qui ont le souci de se démarquer et de mettre en avant leurs ressources les plus spécifiques, à des fins de développement économique.Les ressources culturelles festives, à l’image des carnavals antillais et guyanais et du Tour des yoles rondes de la Martinique, en plus de montrer un lien entre une identité locale, des traditions et un lieu, confèrent de la lisibilité et de la transparence aux territoires qu’elles investissent. Les fêtes locales sont, en effet, des formes spatiales vectrices de territorialité qui donnent à voir des formes d’enracinement et d’attachement aux lieux. C’est d’ailleurs la « cristallisation collective » (Jeudy, 2008) qui se joue autour de ces manifestations patrimoniales festives, qui contribue à leur conférer de la consistance ainsi qu’une non négligeable valeur marchande. A n’en point douter, elles ont la faculté d’établir la Guadeloupe, la Martinique et la Guyane dans le cadre de la distinction, de l’attractivité et de la compétitivité. Néanmoins, n’est ce point utopique de croire, que la valorisation du patrimoine culturel festif des départements étudiés pourrait significativement participer à asseoir la pérennisation du tourisme ? En effet, l’organisation de la fête, surtout lorsqu’elle a une dimension identitaire poussée à son paroxysme, peut conduire au repli d’une société localisée sur elle-même. Partant de ce postulat, la rencontre entre touristes et populations locales peut s’avérer compromise, alors même que ces manifestations culturelles disposent de nombreux atouts à même de satisfaire un public touristique en quête d’authenticité et de vacances divertissantes. Cette rencontre est-elle souhaitée par les uns et les autres ? Est-elle seulement souhaitable ? Le patrimoine culturel festif peut-il sous-tendre une vraie activité touristique, tout en demeurant le garant d’une certaine stabilité sociale ? La prudence ne voudrait-elle pas qu’il faille plutôt craindre la menace qui pèse sur les biens culturels devenus trop rapidement des produits touristiques ?En réalité, les relations sont complexes entre une culture mise en fête et le développement du secteur touristique. Faut-il pour autant les considérer comme un « pari de l’inutile » (Lazzarotti, 2011) ?Le tourisme doit continuer à se penser comme un secteur économique indispensable au développement local, dans une perspective de durabilité. C’est d’ailleurs à ce titre que le volet social du développement durable trouve sa place au cœur même de notre réflexion, tant il constitue une composante majeure de ce que devrait être un produit touristique attractif et adapté aux substrats locaux. C’est ainsi que cette thèse explore et approfondit la problématique de la mise en relation entre un secteur touristique à pérenniser, et le riche patrimoine culturel festif dont disposent la Martinique, la Guadeloupe et la Guyane. Ce travail de recherche poussent encore un peu plus loin la réflexion autour du développement de pratiques touristiques renouvelées et durables.
Enhancement of cultural heritage, both tangible and intangible, is justified as a vector of differentiation, in a context where the only tourist Fordist model no longer recipe. Heritage in which man instead of subjective, cultural and emotional referents and even symbols, would be regarded as a resource, a vector distinction territories, as it is provider of authenticity. Thus, when a role marker of identity , heritage can be mobilized by the actors involved in local development that have the desire to stand out and highlight their most specific resources for economic development purposes . festive cultural resources, like the Caribbean and Guyanese carnivals and Tour round skiffs from Martinique, in addition to showing a link between a local identity, traditions and place , give the clarity and transparency territories they invest . Local festivals are indeed of vector spatial forms of territoriality that give rooting see shapes and place attachment. This is also the "collective crystallization" (Jeudy, 2008) that plays around these festive heritage demonstrations, which helps give them substance and a significant market value. A no doubt, they have the ability to establish Guadeloupe, Martinique and Guyana as part of the award, the attractiveness and competitiveness. However, this is unrealistic enough to believe that the enhancement of cultural heritage festive departments surveyed could significantly participate in sit sustainability of tourism? Indeed, the organization of the party, especially when it has a dimension of identity pushed to its limits, can lead to the decline of localized on society itself. Based on this assumption, the encounter between tourists and local populations may be compromised, even though these cultural events have many assets to satisfy even a tourist public in search of authenticity and fun holiday. This meeting it is desired by each other? Is it just desirable? The festive cultural heritage may underlie it a real tourist activity, while remaining a guarantor of social stability? Prudence does not she want that rather we should fear the threat to cultural property became too quickly tourism products? Actually, relationships are complex between a culture festival setting and development of the tourism sector. Should we all be regarded as a "bet the useless" (Lazzarotti, 2011)? Tourism must continue to think as an essential local economic development sector, with a view to sustainability. It is also for this reason that the social pillar of sustainable development finds its place at the heart of our thinking, as it is a major component of what should be an attractive tourism product adapted to local substrates. Thus this thesis explores and deepens the problem of linking between tourism to sustain, and the rich cultural heritage festive available Martinique, Guadeloupe and Guyana. This research push a little further reflection on the development of tourism practices renewed and sustained.

http://www.theses.fr/2013AGUY0703