Éditeur(s) : Université de Bretagne Occidentale
Résumé : Study of mineral suspended particulate matter (SPM) is essential to understand ecosystem dynamics. SPM influences light penetration which is closely related to primary production and carries pollutants and nutrients within the water masses. This work aims to study near-surface mineral SPM dynamics in the English Channel using two complementary methods: remote-sensing by satellites and numerical modelling. Firstly, MODIS and MERIS satellite images processed by the IFREMER semi-analytical algorithm and describing non-algal SPM, are analysed to build three statistical models which are able to estimate near-surface SPM using simple variables, e.g., tidal coefficient, significant wave height and mean chlorophyll-a concentration. Secondly, the three-dimensional hydrosedimentary model ROMS (Regional Ocean Modeling System) is applied in the English Channel. It considers tidal forcing along open boundaries, wind stress at the sea-surface, wave-current interactions in the bottom boundary layer and realistic heterogeneous bottom sediments. Results of the more sophisticated statistical model is also used to impose SPM concentrations at open boundaries. Sensitivity tests on SPM boundary conditions show the importance of prescribing realistic sediment concentrations to improve the model predictions. Biological influences on mineral SPM are also tested using settling velocity and critical shear stress for erosion which vary with seasons. Both statistical and numerical models highlight and locate respective influences of tide, waves and biology on mineral SPM. Numerical predictions indicate that near-surface SPM is mainly composed of silts (>70%). Near-surface suspended silts come largely from seabed resuspension alongshore in the Eastern Channel and from the open boundaries of our limited-area coastal model at the West of Cotentin Peninsula and offshore. Near-surface SPM variations are investigated at semi-diurnal, neap-spring tidal cycle time scales and during a wave event. Finally, dynamics of sediments in the turbidity maximum zone around the Isle of Wight is examined depending on hydrodynamical conditions in order to distinguish the role played by advection and local erosion/settling processes in this area. Keywords: Suspended particulate matter, satellite, remote-sensing, modelling, English Channel, sediments, turbidity, tide, wave
L'étude des matières en suspension (MES) minérales est essentielle pour comprendre le fonctionnement des écosystèmes en Manche : les MES influencent la pénétration de la lumière dans la colonne d'eau, paramètre clé pour la production biologique, et sont susceptibles de transporter des polluants et nutriments. Lors de ce travail, la dynamique des MES minérales de surface en Manche est étudiée à l'aide de deux méthodes complémentaires : l'observation par satellite et la modélisation numérique tridimensionnelle. Dans un premier temps, les images satellite MODIS et MERIS, traitées par l'algorithme semi-analytique développé par l'IFREMER et représentant les MES non-algales de surface, sont analysées afin d'élaborer trois modèles statistiques permettant d'estimer la MES de surface en fonction de variables basiques telles que le coefficient de marée, la hauteur significative des vagues et la concentration moyenne en chlorophylle-a. Dans un deuxième temps, le modèle hydrosédimentaire multiclasse tridimensionnel ROMS (Regional Ocean Modeling System) est implémenté en Manche. Il prend en considération le forçage par la marée aux frontières ouvertes, la contrainte exercée par le vent à la surface de la mer, l'interaction houle-courant en couche limite de fond et l’hétérogénéité spatiale réaliste du lit sédimentaire. Les résultats du modèle statistique le plus sophistiqué sont également utilisés pour forcer la concentration en MES aux frontières ouvertes du domaine de calcul. Des tests de sensibilité sur les conditions limites montrent l'importance de considérer de manière réaliste les sédiments entrant en Manche par les frontières ouvertes lors de la modélisation numérique. L'influence de la biologie sur les MES minérales est testée en utilisant une formulation de la vitesse de chute et de la contrainte critique d'érosion variant saisonnièrement. Grâce à ces deux outils associés, les influences respectives de la marée, de la houle et de la biologie sur les MES minérales sont mises en avant et localisées en Manche. Le modèle numérique prédit que les MES de surface sont composées principalement de silts (>70%). Les silts en suspension en surface proviennent majoritairement du lit sédimentaire près des côtes en Manche orientale et des frontières ouvertes du domaine de calcul à l'ouest de la presqu'île du Cotentin et au large en Manche centrale et orientale. Les variations des MES de surface sont ensuite étudiées aux échelles des cycles de marée semi-diurnes, vive-eau/morte-eau et autour d'un épisode de houles. Enfin, l'évolution de la concentration de sédiments dans la zone de forte turbidité autour de l'île de Wight peut être analysée suivant les conditions hydrodynamiques afin d'évaluer les rôles respectifs des processus locaux d'érosion/dépot et d'advection dans la génération de ces turbidités remarquables. Mots-clés : Matière en suspension, télédétection, satellite, modélisation, Manche, sédiments, turbidité, marée, houle

Droits : 2013 UBO
http://archimer.ifremer.fr/doc/00157/26783/24884.pdf
http://archimer.ifremer.fr/doc/00157/26783/

Éditeur(s) : Elsevier
Résumé : Dissolved and particulate Hg fluxes in the Lot-Garonne-Gironde fluvial-estuarine system were obtained from observation of daily discharge and suspended particulate matter (SPM) concentrations. In addition to the measurements of the total dissolved (< 0.45 gm) and particulate Hg (> 0.45 gm), called HgTD and HgTp respectively, the dissolved inorganic Hg species (HgRD) were determined monthly. Geochemical background values for HgTp in sediments and SPM were similar to crustal values and to typical concentrations in SPM of non-contaminated river systems, respectively. The Riou Mort watershed already known as the origin of important historical polymetallic (e.g., Cd, Zn) pollution was identified as an important Hg point source. In the downstream Lot River, Hg concentrations were clearly higher than those in other moderately contaminated systems. The mean relative contribution of HgRD to HgTD in the Lot River and in the Garonne River was close to 25% and 50%, respectively, and showed no correlation with water discharge or SPM concentration. Depending on the origin and nature of SPM, HgTp concentrations were correlated or not with particulate organic C (POC). Maximum HgTp concentrations were measured in samples containing low POC concentrations and were attributed to sediment resuspension. In contrast, high POC concentrations (6-17%) during algal blooms were associated with low/moderate HgTp concentrations (< 0.5 mg kg(-1)) at different sites, suggesting that Hg concentrations in fluvial phytoplankton may be limited by bioavailability of dissolved Hg and/or physiologically controlled Hg accumulation. Mercury was mostly (up to 98%) transported in the particulate phase with estimated annual Hg fluxes at the outlet of the Lot River system ranging from 35 to 530 kg a(-1) for the past decade. The minimum anthropogenic component (58-84% of total Hg fluxes) could not be explained by present Riou Mort point source contributions, suggesting important Hg release from contaminated sediment as a major source and from downstream point sources (e.g., coal-fired power plants and/or metal processing industries). HgTp concentrations and fluxes were strongly related to hydrologic variations and were clearly increased by riverbed dredging during lock construction. Therefore, the estimated Hg stocks in the Lot River sediment (5-13 tons) represent an important potential Hg source for the downstream fluvial-estuarine system.
Applied Geochemistry (0883-2927) (Elsevier), 2006-03 , Vol. 21 , N. 3 , P. 515-527

Droits : 2006 Elsevier Ltd All rights reserved
http://archimer.ifremer.fr/doc/2006/publication-1343.pdf
DOI:10.1016/j.apgeochem.2005.12.004
http://archimer.ifremer.fr/doc/00000/1343/

Éditeur(s) : Pergamon-elsevier Science Ltd
Résumé : Sites of monomethylmercury (MMHg) production in Amazonian regions have been identified in hydraulic reservoirs, lake sediments and wetlands, but tailings ponds have not yet received sufficient attention for this purpose. This work evidenced high MMHg production within the water column and the interstitial water of two tailings ponds of French Guiana Au mines located; (i) in a small scale exploitation (Combat) where Hg was used for Au amalgamation, and (ii) in an industrial on-going Au mine (Yaoni) processing without Hg. The (MMHg)(D) maximum (2.5 ng L-1) occurred in the oxic water column above the sediment-water interface (SWI) of the most recent tailings pond (Combat), where the substrate was fresh, the redox transition was sharp and the pool of total Hg was large. In the Yaoni pond, the (MMHg)(D) maximum concentration (1.4 ng L-1) was located at the SWI where suboxic conditions prevailed. Using the (MMHg)(D) concentration as a proxy for Hg methylation rates, the present results show that Hg methylation may occur in various redox conditions in tailings ponds, and are favored in areas where the organic matter regeneration is more active. A 3-month long laboratory experiment was performed in oxic and anoxic boxes filled with high turbidity waters from the Combat Au mine to simulate tailings ponds. Slaked lime was added in an experimental set (2 mg L-1)and appeared to be very efficient for the reduction of suspended particulate matter (SPM) to environmentally acceptable concentrations. However, at the end of the experiment, large (MMHg)(D) concentrations were monitored under treated anoxic conditions with the (MMHg)(D) maximum located at the SWI above the Fe-reducing zones. No (MMHg)(D) was detected in oxic experiments. The use of slaked lime for SPM decantation appears to be an efficient and non-onerous process for Au miners to avoid Hg methylation in tailings ponds when it is combined with rapid drainage of the mine waters. A subsequent human intervention is however necessary for the recovery of soil structure through the cover of dried ponds with organic rich materials and reforestation to avoid the stagnation of rain waters and the occurrence of anoxia. (C) 2010 Elsevier Ltd. All rights reserved.
Applied Geochemistry (0883-2927) (Pergamon-elsevier Science Ltd), 2011-02 , Vol. 26 , N. 2 , P. 222-229

Droits : 2010 Elsevier Ltd All rights reserved.
http://archimer.ifremer.fr/doc/00030/14117/12133.pdf
DOI:10.1016/j.apgeochem.2010.11.022
http://archimer.ifremer.fr/doc/00030/14117/

Éditeur(s) : Elsevier
Résumé : In biological modelling of the coastal phytoplankton dynamics, the light attenuation coefficient is often expressed as a function of the concentrations of chlorophyll and mineral suspended particulate matter (SPM). In order to estimate the relationship between these parameters over the continental shelf of the northern Bay of Biscay, a set of in situ data has been gathered for the period 1998-2003 when SeaWiFS imagery is available. These data comprise surface measurements of the concentrations of total SPM, chlorophyll, and irradiance profiles from which is derived the attenuation coefficient of the photosynthetically available radiation, K-PAR. The performance of the IFREMER look-up table used to retrieve the chlorophyll concentration from the SeaWiFS radiance is evaluated on this new set of data. The quality of the estimated chlorophyll concentration is assessed from a comparison of the variograms of the in situ and satellite-derived chlorophyll concentrations. Once the chlorophyll concentration is determined, the non living SPM, which is defined as the SPM not related to the dead or alive endogenous phytoplankton, is estimated from the radiance at 555 nm by inverting a semi-analytic model. This method provides realistic estimations of concentrations of chlorophyll and SPM over the continental shelf all over the year. Finally, a relationship, based on non living SPM and chlorophyll, is proposed to estimate K-PAR on the continental shelf of the Bay of Biscay. The same formula is applied to non living SPM and chlorophyll concentrations, observed in situ or derived from SeaWiFS radiance.
Remote Sensing of Environment (0034-4257) (Elsevier), 2005-03 , Vol. 95 , N. 1 , P. 29-46

Droits : 2004 Elsevier Inc. All rights reserved
http://archimer.ifremer.fr/doc/2005/publication-1172.pdf
DOI:10.1016/j.rse.2004.11.007
http://archimer.ifremer.fr/doc/00000/1172/

Éditeur(s) : HAL CCSD
Résumé : This paper studies the biological and economic effects of globalwarming on the French Guiana shrimp …fishery. The sea surface tem-perature is explicitly introduced into four natural growth functions,among which the Cobb-Douglas function best adjusts the availabledata. Besides, a Cobb-Douglas harvest function is also estimated, in-dicating that shrimp production in French Guiana is highly sensitive tothe shrimp stock, which implies that global warming may have strongeconomic implications. We …nally consider a centralized resource man-agement of the French Guiana shrimp …shery, that is undertaken invarious trend scenarios concerning the sea surface temperature. Un-der the most plausible scenario, in which the sea surface temperaturefollows the trend of the last decades, pro…ts and biomass respectivelydecrease and collapse around the end of the 2020’s.
https://hal.univ-antilles.fr/hal-01243305

hal-01243305
https://hal.univ-antilles.fr/hal-01243305
https://hal.univ-antilles.fr/hal-01243305/document
https://hal.univ-antilles.fr/hal-01243305/file/Diop%20et%20al.%20%282015%29.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Background: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. Methods: We enrolled 14,005 mothers (2002-2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities was recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case-control studies. Results: Average levels of trihalomethanes ranged from around 10 μg/L to above the regulatory limits in the EU of 100 μg/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (β = 2.2 g in birth weight per 10 μg/L of trihalomethane, 95% confidence interval = 3.3, 7.6). Birth weight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (odds ratio [OR] per 10 μg/L = 1.02, 95% confidence interval = 0.95, 1.10), small-for-gestational age (OR = 0.99, 0.94, 1.03) and preterm births (OR = 0.98, 0.9, 1.05). We found no gene-environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. Conclusions: In this large European study, we found no association between birth outcomes and trihalomethane exposures during pregnancy in the total population or in potentially genetically susceptible subgroups. © 2016 Wolters Kluwer Health, Inc.
Epidemiology

hal-01392115
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01392115
DOI : 10.1097/EDE.0000000000000544
PUBMED : 27468006

Éditeur(s) : HAL CCSD
Résumé : National audience
Objective of the study An estimation of burden of serious fungal diseases in France is essential data to inform public health priorities on the importance of resources and research needed on these infections. In France, precise data are available for invasive fungal diseases but estimates for several other diseases such as chronic and immunoallergic diseases are by contrast less known. Materials and methods A systematic literature search was conducted using the Web of Science Platform. Published epidemiology papers reporting fungal infection rates from France were identified. Where no data existed, we used specific populations at risk and fungal infection frequencies in those populations to estimate national incidence or prevalence, depending on the condition. Results The model predicts high prevalences of severe asthma with fungal sensitization episodes (189 cases/100,000 adults per year), of allergic bronchopulmonary aspergillosis (145/100,000) and of chronic pulmonary aspergillosis (5.24/100,000). Besides, estimated incidence for invasive aspergillosis is 1.8/100,000 annually based on classical high risk factors. Estimates for invasive mucormycosis, pneumocystosis and cryptococcosis are 0.12/100,000, 1/100,000 and 0.2/100,000, respectively. Regarding invasive candidiasis, more than 10,000 cases per year are estimated, and a much higher number of recurrent vaginal candidiasis is probable but must be confirmed. Finally, this survey was an opportunity to report a first picture of the frequency of tinea capitis in France. Conclusion Using local and literature data of the incidence or prevalence of fungal infections, approximately 1,000,000 (1.47%) people in France are estimated to suffer from serious fungal infections each year. © 2016 Elsevier Masson SAS
Journal de Mycologie Medicale

hal-01467554
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467554
DOI : 10.1016/j.mycmed.2016.11.001
PUBMED : 27887809

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0168-583X

hal-01685803
https://hal.univ-antilles.fr/hal-01685803
DOI : 10.1016/0168-583X(93)90750-Z

Éditeur(s) : HAL CCSD Optical Society of America
Résumé : International audience
We present a theoretical simulation of the sarcomeric SHG intensity pattern (SHG-IP) that takes into account myofibrillar misalignment that is experimentally observed in SHG images of proteolysed muscles. The model predicts that myofibrillar displacement results in the conversion from one peak (1P) to two peaks (2P) sarcomeric SHG-IP in agreement with experimental results. This study suggests that sarcomeric SHG-IP is a powerful tool for mapping spatial myofibrillar displacement and its related excitation-contraction disruption that could occur during muscle physiological adaptation and disease.
ISSN: 1094-4087

hal-00820260
https://hal.archives-ouvertes.fr/hal-00820260
https://hal.archives-ouvertes.fr/hal-00820260/document
https://hal.archives-ouvertes.fr/hal-00820260/file/Studysur the_effect-accepted.pdf
DOI : 10.1364/OE.21.011404

Éditeur(s) : HAL CCSD
Résumé : National audience
Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire
Paris, France

hal-01122677
https://hal.archives-ouvertes.fr/hal-01122677

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0257-8972

hal-01685814
https://hal.univ-antilles.fr/hal-01685814
DOI : 10.1016/0257-8972(92)90273-D

Éditeur(s) : HAL CCSD
Résumé : International audience
Two fluorescent galactofuranosides were synthesized and their biological activities evaluated on non-infected and Leishmania infected macrophages. Both tagged scaffolds were able to penetrate macrophages. Compared to the activity of the parent octyl galactofuranoside used as a reference, the fluorescein-conjugate showed altered biological properties while the rhodamine 6G one synergistically acted with the lipid chain to significantly increase antiparasitic activity.
Bioorganic & Medicinal Chemistry Letters

hal-01446721
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01446721
PUBMED : 27956346
DOI : 10.1016/j.bmcl.2016.11.090

Éditeur(s) : HAL CCSD Royal Society of Chemistry
Résumé : International audience
Although leishmaniasis has been studied for over a century, the fight against cutaneous, mucocutaneous and visceral forms of the disease remains a hot topic. This review refers to the parasitic cell wall and more particularly to the constitutive glycoconjugates. The structures of the main glycolipids and glycoproteins, which are species-dependent, are described. The focus is on the disturbance of the lipid membrane by existing drugs and possible new ones, in order to develop future therapeutic agents
ISSN: 1477-0520

hal-01174899
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01174899
DOI : 10.1039/c5ob00563a
PUBMED : 26130402

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Because many biological processes related to the dynamics of infectious diseases are caused by complex interactions between the environment, the host(s) and the agent(s), the necessity to address the methodological implications of this inherent complexity has recently emerged in epidemiology. Most epidemiologists now acknowledge that most human infectious diseases are likely to have complex dynamics. However, this knowledge still percolates with difficulty in their statistical "modus operandi". Indeed, for the study of complex systems, the traditional first-line statistical toolbox of epidemiologists (mainly built around the Generalized Linear Model family), despite its undeniable practicality and robustness, has structural limitations deprecating its usefulness. Three major sources of complexity neglected or not taken into account by this first-line statistical toolbox and having deep statistical implications are the multi-level organization of data, the non-linear relationships between variables and the complex interactions between variables. Three promising candidates to incorporate along with traditional tools for a new first-line statistical toolbox more suitable to apprehend these sources of complexity are the generalized linear mixed models, the generalized additive models, and the structural equation models. The aforementioned methodologies have the advantage to be generalizations of GLM models and are relatively easy to implement. Their assimilation and implementation would thus be greatly facilitated for epidemiologists. More globally, this text underlines that an improved use of other methods as such described here compared to traditional ones has to be performed to better understand the complexity challenging epidemiologists every day. This is particularly true in the field of infectious diseases for which major public health challenges will have to be addressed in the coming decades.
ISSN: 1567-1348

inserm-00872354
http://www.hal.inserm.fr/inserm-00872354
http://www.hal.inserm.fr/inserm-00872354/document
http://www.hal.inserm.fr/inserm-00872354/file/main_document.pdf
DOI : 10.1016/j.meegid.2013.09.006

Résumé : Face aux difficultés d’identification des arbres de la famille des Lauracées et dans un but d’établissement d’une production durable et certifiée d’huiles essentielles, l’entreprise KLR a voulu mettre en place un nouvel outil d’identification multi-critères qui consiste à croiser plusieurs types de caractères afin d’obtenir une détermination taxonomique fiable.Trois méthodes d’identification ont été utilisées : la chimie (analyse de l’odeur de l’écorce), le code barre génétique et l’anatomie du bois. Une analyse par positionnement multidimensionnel non-métrique a permis de faire un tri des critères anatomiques du bois pertinents dans l’identification des Lauracées étudiées, au final 14 critères ont été retenus. D’après les données anatomiques dont nous disposons, nous proposons une clé de détermination au genre. En génétique, la technique de code barres de la région chloroplastique intergénique trnH-psbA a été appliquée aux individus récoltés. En comparant les séquences de tous les individus, 40% des individus peuvent être identifiés au genre car ils présentent des haplotypes uniques. Des haplotypes au sein des genres ont été déterminés et permettent d’identifier l’espèce pour 40 à 100 % des individus selon le genre. L’analyse SPME de l’odeur des écorces a permis de définir pour chaque espèce une carte d’identité chimique à partir des molécules majoritaires. Des chémotypes ont été définis au sein des espèces Licaria cannella, Ocotea indirectinervia et Sextonia rubra. Ces trois domaines d’observation ont permis de constituer une base de type Xper2 pour l’identification.Un criblage des essences intéressantes de par leur rendement en huile essentielle a été effectué. En ce qui concerne la partie extraction de l’huile essentielle, trois espèces montrent un rendement en huile essentielle de l’écorce supérieur à 0,3% et 5 espèces montrent un rendement en huile essentielle du bois supérieur à 0,3%. Les évaluations olfactives menées par un expert ont permis de séparer les huiles distillées en 5 différentes notes. Nous avons jugé intéressant de savoir si l’outil d’identification multicritère pouvait prédire les compositions et rendements en huile essentielle de l’espèce identifiée avant l’abattage de l’arbre. Des études complémentaires ont donc été menées. Pour plus de la moitié des arbres, la signature de l’écorce, la composition de l’huile essentielle de l’écorce et la composition de l’huile essentielle du bois sont similaires. La tentative d’établir un lien entre les caractéristiques des cellules à huile et le rendement s’est avérée infructueuse.
In order to develop a sustainable production of certified essential oils extracts, the compangy KLR has struggled with the identification of the trees from the family of Lauraceae. This is the main reason that led to the project of creating an identification tool for this family.This tool would be based on three approaches: chemistry (chemical signature of the dark), wood anatomy and genetic barcoding. By means of a non-metric multidimensional scaling analysis, we selected a list of 14 relevant wood anatomical features that can identify the trees to the genera. For the genetics, the barcoding of trnH-psbA an intergenic region of the DNA has been used. When comparing all the sequences from all the individuals, 40% of the individuals can be identified to the genera because of their specific haplotype. Haplotypes within the genera have also been established. Chemical identity cards have been set with the SPME analysis technique and chemotypes have been defined inside the species Licaria cannella, Ocotea indirectinervia and Sextonia rubra. These three identification approaches allowed us to construct an identification tool on Xper².During the study, we aimed to screen what species would be interesting for its essential oil yield. Three species showed an essential oil bark yield above 0.3%. five species showed an essential oil wood yield above 0.3%. An expert held an olfactory evaluation on the oils and divided the essential oils in five olfactory groups. We found it relevant to improve the identification tool by trying to predict the compositions of the oils before the three was cut down. In the case of the half of trees studied by SPME analyses, the composition of the wood and the bark essential oils were similar. On the other hand, no link was found between the oil cells dimensions and the essential oil yield.

http://www.theses.fr/2012AGUY0516/document

Éditeur(s) : HAL CCSD American Chemical Society
Résumé : International audience
Constitutive activation of the PI3K/mTOR signaling pathway contributes to carcinogenesis and metastasis in most, if not all, breast cancers. From a chromene backbone reported to inhibit class I PI3K catalytic subunits, several rounds of chemical syntheses led to the generation of a new collection of chromologues that showed enhanced ability to kill PI3K-addicted cancer cells and to inhibit Akt phosphorylation at serine 473, a hallmark of PI3K/mTOR activation. This initial screen uncovered a chromene designated DHM25 that exerted potent antitumor activity against breast tumor cell lines. Strikingly, DHM25 was shown to be a selective and covalent inhibitor of mTOR using biochemical and cellular analyses, modeling, and a large panel of kinase activity assays spanning the human kinome (243 kinases). Finally, in vivo, this novel drug was an efficient inhibitor of growth and metastasis of triple-negative breast cancer cells, paving the way for its clinical application in oncology
ISSN: 0022-2623

hal-01187307
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01187307
DOI : 10.1021/acs.jmedchem.5b00991
PUBMED : 26237138

Éditeur(s) : HAL CCSD Society of Nuclear Medicine
Résumé : International audience
ISSN: 0161-5505

hal-01117641
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117641

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0168-583X

hal-01685818
https://hal.univ-antilles.fr/hal-01685818
DOI : 10.1016/0168-583X(91)95793-D

Éditeur(s) : HAL CCSD Centers for Disease Control and Prevention
Résumé : International audience
To determine when risk for Buruli ulcer is highest, we examined seasonal patterns in a highly disease-endemic area of Cameroon during 2002-2012. Cases peaked in March, suggesting that risk is highest during the high rainy season. During and after this season, populations should increase protective behaviors, and case detection efforts should be intensified.
ISSN: 1080-6040

Droits : http://creativecommons.org/licenses/by-nc-nd/
hal-01307147
https://hal-amu.archives-ouvertes.fr/hal-01307147
https://hal-amu.archives-ouvertes.fr/hal-01307147/document
https://hal-amu.archives-ouvertes.fr/hal-01307147/file/14-1336.pdf
DOI : 10.3201/eid2108.141336

Éditeur(s) : HAL CCSD springer Link
Résumé : International audience
Experimental Astronomy

hal-01094521
https://hal.archives-ouvertes.fr/hal-01094521
BIBCODE : 2014ExA...tmp...41R
DOI : 10.1007/s10686-014-9383-4
ARXIV : 1310.0696