Résumé : From the PNCR, GAP MPs free to vote conscience on gay rights bill By Johann Earle Stabroek News June 11, 2003 The PNCR will allow its members to vote their conscience on the controversial Constitution (Amendment) Act of 2001 which seeks to prevent discrimination against persons on the basis of their sexual orientation and other grounds. A number of religious organisations are opposed to the passage of the bill because it includes sexual orientation as one of the grounds. They are concerned that it could lead to a legalisation of homosexual relations and demands for recognition of gay marriages among other things. PNCR Member of Parliament (MP) Vincent Alexander told a forum at the National Library on Saturday, that the Bill did not seek to legalise homosexuality, but to ensure that persons would not be discriminated against based on their sexual preferences. He was one of two parliamentarians who showed up - the other being PNCR member, Myrna Peterkin. The forum was organised by Students Against Sexual Orientation Discrimination (SASOD), a group comprising fifteen students from the University of Guyana which was formed about two weeks ago. Alexander expects the vote on the bill to come up before the National Assembly in a matter of months. Paul Hardy, Leader of the Guyana Action Party (GAP), told Stabroek News that his party would not be using the so-called parliamentary whip. He added that GAP took a decision that every member should vote according to his or her own conscience. “We have no right to deny the rights of others based on sexual orientation. [The Bill] will guarantee rights to the homosexual.” GAP is in Parliament as part of an alliance with the Working People’s Alliance. GAP/WPA has two MPs. The bill was met with rejection from some members of the religious community in 2001 and as a result of this, the President did not assent to it. In a statement on Monday, the Central Islamic Organisa-tion of Guyana (CIOG) said that it stood in firm opposition to the Bill. The CIOG says the general purpose of the bill may be commendable and that the organisation’s objection is not based on a willingness to promote discrimination. Rather, the CIOG said, it was based on the fact that specific legal protection on the basis of sexual orientation without definition or qualification gives tacit legitimacy to practices which are considered criminal in Islam. “It is foreseeable that such a legal nod of approval (subtle as it may be) of these practices may pave the way for greater social (or even legal) acceptability in the future which, from the perspective of all Muslims including those in Guyana, is an undesirable and sinful outcome,” the CIOG statement said. At Saturday’s event, Muslim teacher Moulana Mohamed Ali Zenjibari spoke of instances of abuse, discrimination and harsh penalties meted out to gay and lesbian persons in countries such as Iran and Saudi Arabia and noted that the Quran did not sanction such punishments for homosexual behaviour. President of the CIOG, Fazeel Ferouz told Stabroek News that a meeting to discuss a strategy with regards to the bill was planned for tomorrow with various religious groups. Stabroek News tried to get a comment on the issue from the PPP/C but to no avail. ROAR leader, Ravi Dev said that his party was now having discussions on the issue. ROAR feels that it is an important question which has to do with morality and should be discussed across the country. He added legislators had to be in tune with their constituents on the issue. SASOD is lobbying for the legislation through the sensitisation of MPs. Keimo Benjamin, a law student at UG, gave a presentation based on the jurisprudential aspects of the discussion on sexual orientation. He argued that morality should not be the only guiding principle on which to base the laws. Sexual activities between two consenting male adults in private could not be equated with a violation of a person’s rights, he said, making the point that the thrust of his presentation was not whether homosexuality was wrong, but whether it violated the rights of others. He said that the attitudes of some towards this subject were based on preconceived notions and prejudices. He cited studies to show that the suppression of certain perceived deviant sexual impulses in persons might do more harm than good. One Harvard University study of teens who said they were gay indicated that those teens were three times more likely to commit suicide. Vidyaratha Kissoon, of Help and Shelter, in his contribution on Saturday, expressed his displeasure at the low turnout at the forum and urged the parliamentarians who showed up to take the message to their colleagues. He noted that because of homophobia, the numerical minority was terrified of speaking out against instances of discrimination. Gays and lesbians in Guyana were subjected to ridicule and abuse, and walk the streets at night not looking for sex necessarily, but for the companionship of persons who empathise with them. During his presentation, Joel Simpson, another member of SASOD, outlined a number of changes made within national jurisdictions that had international implications. One such crucial change was South Africa’s 1996 adoption of a new constitution, making that country the first in the world to expressly include sexual orientation as a prohibited ground of discrimination. It was the first time a developing country had taken the lead with respect to the rights of sexual minorities. He also said that according to Douglas Sanders, a Canadian jurist, the rights of homosexual, bisexual or transsexual men and women had never been officially recognised by the United Nations, despite the fact that international laws on the issue began to emerge at the close of the Second World War. Simpson said that under Article 170 (5), as amended by Section 8 of the Constitution (Amendment) (No. 4) Act 2000, the President is required to assent to any bill which is returned by the National Assembly unaltered after a two-thirds majority within 90 days of its presentation to him. To the parliamentarians present, Simpson stressed that the onus was now on them to adequately represent their constituents which include lesbian, gay, bisexual and transsexual Guyanese. http://www.landofsixpeoples.com/news301/ns306115.htm and Vote on sexual orientation should be a matter of conscience - MP Alexander By Esther Elijah Guyana Chronicle June 8, 2003 PEOPLE’S National Congress (PNC/R) Member of Parliament Mr. Vincent Alexander, said the Opposition will vote on “conscience” when the piece of legislation on sexual orientation is again brought before the National Assembly. “With specific reference to my party, when this Bill gets back to the Parliament in the spirit of the arguments here, we will not use the `whip’. Our party will not say we have to vote for the provision (in the Sexual Orientation Bill). We will allow our members to vote as a matter of conscience,” he told participants gathered in the Conference Room of the National Library. “We feel this is a matter of conscience. You may end up with a collective position but you have to deal with us individually,” Alexander said at a poorly attended public consultation aimed at gaining support for sexual orientation to be considered a fundamental right in Guyana. Alexander, one of the main persons who sat on the Constitutional Reform Commission that addressed this controversial clause, said the legislation was not meant to legalise homosexual activities in Guyana. “It was intended to ensure that persons who have an orientation - a way of thinking - which may or may not lead to a certain activity, to not be discriminated against, in terms of their rights,” he explained. Alexander noted that very often, discussions on the sexual orientation provision in the Bill have led to seepages into other areas where debates centre on the “right to be homosexual.” “I am saying the Bill does not comment on that… However, law is peculiar, especially in a Common Law system. Once you venture out and change the law, very often you open other windows which we cannot definitively say exist or does not exist in advance,” he said. “The fear of some people is that the legislators might say one thing and the Courts will eventually say something else. While some people can’t argue against the law, per say, they will say this has opened a window of opportunity not meant to be opened. So, it is better to stay without a window than open it and then have a possibility of something you didn’t intend to happen - happening sometime in the future.” Alexander added: “I want to say I’ve found this activity to have been rich from the perspective of the amount of research which was done by student (speakers). Without any comment as to whether I agree with the arguments, I would wish that much more research on other issues be done by students, and that at the University (of Guyana) students would find it convenient to have forums on other issues, with the same depth of research for their own intellectual development.” Alexander and other Opposition M.P, Lurlene Nestor were the only three Parliamentarians in attendance at the session organised by the recently formed `Students Against Sexual Orientation Discrimination’ (SASOD), a group that has a membership of 15 mostly University of Guyana (UG) students from various faculties. SASOD was established two weeks ago. With the exception of members of the press, the consultation only managed to attract 11 persons, a handful of who were SASOD members. While congratulating the students for an “insightful” presentation, Nestor pointed out that whether or not she chooses to agree with their position is “another issue” and she is entitled to her “own view”. “The issue of sexual orientation is very `toucheous’ …while we agree with the human rights provisions and all that as a society, we must also revert to our own society. Some of the very critical questions that I would want to ask is whether or not at the society (level) we are ready for that kind of thing,” she remarked. “We cannot, at (any) time, ignore the religious groups in our society. If we look at statistics going back to 1992 from a survey done by the Bureau of Statistics, we would see that a small section of the Guyanese population might be considered as people who do not subscribe to a religious view. While the laws are not necessarily based on moral values, we must acknowledge the fact that we might want to revert to many of the cases that (concern) laws that protect public morality.” Nestor told the speakers at the consultation these were some of the issues that they needed to deal with. She highlighted, too, that what must be examined is the effects of same-sex marriages on society and how this issue must be tackled. “These are some of the things we should consider and I don’t think you dealt with that in the presentations,” Nestor stated, adding that the issues must be addressed “frontally.” “Do we think that with the coming to being of this Bill that there might be quite a number of challenges to the Constitution in relation to the same issue of a man marrying a man? What do we do at the society (level)? Do we recognise that?” were the questions directed at the five speakers at the session. Nestor continued: “There is some argument that says, `Oh the Bill does not promote homosexuality or does not encourage a man to marry (another) man, but if you look at Section (15) that talks about `non-discrimination’ then how can we not, with the passage of this Bill, allow a man not to marry (another) man.” According to Nestor, matters of this nature constitute some of the “inconsistencies” of the Bill. On the argument raised by presenters at the session on who determines what is morality, Nestor said in the concept of democracy it is the people who are the determinants based on a “line of thinking.” She also rebutted on grounds that put the spotlight on teachers who may have been caught “interfering” with their young students and who may subsequently be dismissed from their jobs. “Could you imagine such a person interfering with a boy below age 10 - and by virtue of the fact that the Bill is there, the judges (in the case) will have to use their discretion in terms of what happens. We will have more Constitutional changes and problems (arising with the passage of the Bill).” SASOD member and law student, Joel Simpson, in reply, said he doesn’t think any homosexual in Guyana wants to “run into a church and ask that people marry them or anything of that sort.” At one point likening the church to a “club”, Simpson claimed the church has the right to exclude whomever it wants. He further stated that in accordance with the Constitution, people of the same sex do not currently have the right to marry, and will also not be able to do such an act with the passage of the Bill. However, Simpson said it is possible that the law, with the passage of the Bill, would have to recognise same-sex domestic partnerships in relation to employment benefits, sharing of properties, etc. Simpson said he believes there should be a realm of “public” and “private” morality between consenting adults, and implied that the Bill did not fully give “rights” to homosexuals. But, Nestor interjected: “I am informing you further…that the Sexual Orientation provision has, in fact, in some way recognised the rights of homosexuals and we must accept that.” Meanwhile, there was no vocal Christian representative(s) at the consultation and apart from the two Opposition representatives none other participant gave comments or directed questions at the presenters. Other speakers in support of the sexual orientation clause were: Moulana Mohammed Ali Zenjiban, Assistant Director of the International Islamic College; Denuka Radzik from Red Thread, Keimo Benjamin, UG law student and Vidyartha Kissoon from Help & Shelter. The Sunday Chronicle has been reliably informed that the Georgetown Ministers Fellowship, representing groups of Christian leaders staunchly against sexual orientation as a right in Guyana, have recently prepared a detailed 16-page document outlining issues arising from research to further boost their argument against the inclusion of the clause. The document is yet to be made public. http://www.landofsixpeoples.com/news301/nc306083.htm

Droits : All rights reserved by the source institution.
http://ufdc.ufl.edu/AA00014700/00001

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Ethnopharmacological relevancePsidium acutangulum Mart. ex DC is a small tree used by the Wayana Amerindians from the Upper-Maroni in French Guiana for the treatment of malaria.Aim of the studyIn a previous study, we highlighted the in vitro antiplasmodial, antioxidant and anti-inflammatory potential of the traditional decoction of P. acutangulum aerial parts. Our goal was then to investigate on the origin of the biological activity of the traditional remedy, and eventually characterize active constituents.Materials and methodsLiquid-liquid extractions were performed on the decoction, and the antiplasmodial activity evaluated against chloroquine-resistant FcB1 ([3H]-hypoxanthine bioassay) and 7G8 (pLDH bioassay) P. falciparum strains, and on a chloroquine sensitive NF54 ([3H]-hypoxanthine bioassay) P. falciparum strain. The ethyl acetate fraction (D) was active and underwent bioguided fractionation. All the isolated compounds were tested on P. falciparum FcB1 strain. In vitro anti-inflammatory activity (IL-1β, IL-6, IL-8, TNFα) of the ethyl acetate fraction and of an anti-Plasmodium active compound, was concurrently assessed on LPS-stimulated human PBMC and NO secretion inhibition was measured on LPS stimulated RAW murine macrophages. Cytotoxicity of the fractions and pure compounds was measured on VERO cells, L6 mammalian cells, PBMCs, and RAW cells.ResultsFractionation of the ethyl acetate soluble fraction (IC50 ranging from 3.4 to <1 µg/mL depending on the parasite strain) led to the isolation of six pure compounds: catechin and five glycosylated quercetin derivatives. These compounds have never been isolated from this plant species. Two of these compounds (wayanin and guaijaverin) were found to be moderately active against P. falciparum FcB1 in vitro (IC50 5.5 and 6.9 µM respectively). We proposed the name wayanin during public meetings organized in June 2015 in the Upper-Maroni villages, in homage to the medicinal knowledge of the Wayana population. At 50 µg/mL, the ethyl acetate fraction (D) significantly inhibited IL-1β secretion (−46%) and NO production (−21%), as previously observed for the decoction. The effects of D and guiajaverin (4) on the secretion of other cytokines or NO production were not significant.ConclusionsThe confirmed antiplasmodial activity of the ethyl acetate soluble fraction of the decoction and of the isolated compounds support the previous results obtained on the P. acutangulum decoction. The antiplasmodial activity might be due to a mixture of moderately active non-toxic flavonoids. The anti-inflammatory activities were less marked for ethyl acetate fraction (D) than for the decoction.
ISSN: 0378-8741

hal-01313006
http://hal.upmc.fr/hal-01313006
http://hal.upmc.fr/hal-01313006/document
http://hal.upmc.fr/hal-01313006/file/Houel_Wayanin_and.pdf
DOI : 10.1016/j.jep.2016.04.053

Résumé : From the joint media release (http://sasod.blogspot.com/2013/09/joint-media-release-from-thesociety.html ) " The Chief Justice said that cross-dressing in a public place is an offence only if it is done for an improper purpose. The Chief Justice also found that the police violated the human rights of the four litigants in the case during their crackdown in February 2009 when they arrested them under section 153(1)(xlvii) of the Summary Jurisdiction (Offences) Act and he awarded each of the four arrested compensation of $40,000 (GYD) for breach of their rights to be informed as soon as reasonably practicable as to the reason(s) for their arrests under Article 139 (3) of the Guyana Constitution. Chief Justice Chang also decided that section 153 (1) (xlvii) of the Summary Jurisdiction (Offences) Act, is immune from the constitutional challenge brought by the four transgender litigants and their supporting organisations. As an 1893 law, pre-dating Guyana’s independence, the Chief Justice said “legislative rather than curial action is necessary to invalidate the provision.”

Droits : All rights reserved by the source institution.
http://ufdc.ufl.edu/AA00016900/00001

Éditeur(s) : Université des Antilles AREBio Groupe de recherche BIOSPHERES : BIOlogie, Sciences Physiques & Humaines pour les énergies Renouvelables, l
Extrait de : 1er colloque international BIOSPHERES, du 18 au 20 juin 2019. Université des Antilles
Description : Volcano tourism plays an important role in the economies of volcanic islands in the Lesser Antilles. On islands like St. Lucia and Dominica these volcanoes have been utilized as geoparks and the areas even being designated as World Heritage Sites. In many of these islands, farming communities also live on the slopes to these volcanoes and with the increased pursuit of geothermal energy the siting of geothermal operations are also located in close proximity. Volcanic activity, therefore, has a significant impact on these islands at a local and national level. Many volcanomonitoring institutions face the financial and human resources challenge of providing ongoing monitoring services to economically burdened small island states. This has often led to the exploration of alternative low-cost monitoring options and strategies to be adopted by monitoring agencies. One such strategy is the adoption of a volcanic risk reduction approach to research and monitoring activities, which integrates the social and physical sciences through the engagement of local communities as partners with scientists in disaster risk reduction. We present a recent approach adopted using this type of strategy in St. Lucia and lessons learnt from this approach with implications for volcano tourism on island. The potential use of this strategy in Dominica is also presented, given the economic challenges the island currently faces during its ongoing recovery efforts from Hurricane Maria in 2017.

Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V19086
V19086

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Pyrethroids are widely-used chemical insecticides, to which humans are commonly exposed, and known to alter functional expression of drug metabolizing enzymes. Limited data have additionally suggested that drug transporters, that constitute key-actors of the drug detoxification system, may also be targeted by pyrethroids. The present study was therefore designed to analyze the potential regulatory effects of these pesticides towards activities of main ATP-binding cassette (ABC) and solute carrier (SLC) drug transporters, using transporter-overexpressing cells. The pyrethroids allethrin and tetramethrin were found to inhibit various ABC and SLC drug transporters, including multidrug resistance-associated protein (MRP) 2, breast cancer resistance protein (BCRP), organic anion transporter polypeptide (OATP) 1B1, organic anion transporter (OAT) 3, multidrug and toxin extrusion transporter (MATE) 1, organic cation transporter (OCT) 1 and OCT2, with IC50 values however ranging from 2.6 muM (OCT1 inhibition by allethrin) to 77.6 muM (OAT3 inhibition by tetramethrin) and thus much higher than pyrethroid concentrations (in the nM range) reached in environmentally pyrethroid-exposed humans. By contrast, allethrin and tetramethrin cis-stimulated OATP2B1 activity and failed to alter activities of OATP1B3, OAT1 and MATE2-K, whereas P-glycoprotein activity was additionally moderately inhibited. Twelve other pyrethoids used at 100 muM did not block activities of the various investigated transporters, or only moderately inhibited some of them (inhibition by less than 50%). In silico analysis of structure-activity relationships next revealed that molecular parameters, including molecular weight and lipophilicity, are associated with transporter inhibition by allethrin/tetramethrin and successfully predicted transporter inhibition by the pyrethroids imiprothrin and prallethrin. Taken together, these data fully demonstrated that two pyrethoids, i.e., allethrin and tetramethrin, can act as regulators of the activity of various ABC and SLC drug transporters, but only when used at high and non-relevant concentrations, making unlikely any contribution of these transporter activity alterations to pyrethroid toxicity in environmentally exposed humans.
ISSN: 1932-6203

hal-01477206
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477206
DOI : 10.1371/journal.pone.0169480
PUBMED : 28099443

Éditeur(s) : Himalayan Academy Himalayan Academy ( United States )
Résumé : (Funding) Support for the development of the technical infrastructure and partner training provided by the United States Department of Education TICFIA program.
(Acquisition) This article is published in Hinduism Today http://www.hinduismtoday.com and is shared by the author Vidyaratha Kissoon email vidyak1 (at) gmail dot com. The author Vidyaratha Kissoon has proposed the following corrections to the PDF version. Some corrections have been made in the print version and in the online edition. Errata Sheet for "Guyana's Hindus face Gay Quandary" Page 60 1) The caption on the photograph should be "Activists from the Caribbean at a human rights advocacy workshop in Guyana in August 2010" - 2) The line "After being ruled by the Dutch, the Spanish and finally the British ... " should read "After being ruled by the Dutch and the British".. 3) The line 'Revisions and amendments to the constitution are relatively common' to 'Revisions and amendments to the constitution are necessary to achieving this nationhood' 4) The phrase "Congress of Guyana" should be changed to "Parliament of Guyana" Page 61 4) The line "Hindu institutions were mostly absent from the 2001 debate except for a joint statement issued by a few organisations.." should read "Hindu institutions were mostly absent from the 2003 debate except for a joint multifaith statement which included a few organisations .." 6) The comments by Former UN Secretary General Kofi Annan - referred to laws like those in Guyana (the British colonial Caribbean) 7) The last sentence should read "Freedom of worship is ... and each of the main groups has national holidays [Christmas, Easter, Diwali, Phagwah, Eid ul Adha, Youman Nabi] Page 62 8) The line "Pandit Dhanesar was not able.. " to "Pandit Dhanesar did not provide any specific reference in the Vedas. In Guyana, many Pandits sustain traditions a mix of oral and written traditions" 9) The line "Active in helping the gay and lesbian communities, he advocates acceptance." should read "He advocates acceptance .. " The corrected version of the article appears online at http://hinduismtoday.com/modules/smartsection/item.php?itemid=5172

Droits : All rights reserved by the source institution.

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Are bisphenol A (BPA) and BPA analogs (BPA-A) safe for male human reproductive function? The endocrine function of human testes explants [assessed by measuring testosterone and insulin-like factor 3 (INSL3)] was impacted by exposure of the human adult testis explants to BPA/BPA-A. The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption. Adult human testis explants in culture were exposed to BPA and the analogs bisphenol F (BPF), bisphenol S (BPS), bisphenol E (BPE), bisphenol B (BPB) and bisphenol A diglycidyl ether (BADGE) at 10(-9)-10(-5) M for 24 or 48 h. Human adult testes were obtained from prostate cancer patients who had no hormone therapy, or from multiorgan donors. After ex vivo exposure to the investigated bisphenols, the measured outcomes were related to histopathology (gross morphology and germ cell viability determined by anti-caspase three immunohistochemistry), and the levels of testosterone, INSL3 and inhibin B were measured using immunoassays. The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase). A significant dose-dependent inhibition was found between testosterone levels measured in the culture medium and concentrations of BPA (P = 0.00778 at 24 h and P = 0.0291 at 48 h), BPE (P = 0.039) and BPF (P = 0.00663). The observed BPA and BPA-A-induced inhibition of testosterone production varied according to duration of exposure and BPA/BPA-A concentrations. BPA (10(-9) M; P < 0.05), BPB (10(-9) M; P < 0.05), BPS (10(-9) and 10(-8) M; P < 0.05) and BADGE (10(-5) M; P < 0.05) increased Leydig cell INSL3 production. By contrast, BPE dose dependently inhibited INSL3 (P = 0.0372). Conversely, Sertoli cell function (inhibin B) and germ cell viability were not significantly affected by either bisphenols. N/A. Environmental compounds cannot be deliberately administered to men, justifying the use of an ex vivo approach. A relatively low number of testes samples were available for analysis (n = 3, except for testosterone secretion with n = 5). The active concentrations of BPA and BPA-A used in the study were higher than those found in human biological fluids. Under our experimental conditions, direct exposure to BPA or BPA-A can result in endocrine disturbance in the adult human testis.
ISSN: 0268-1161

hal-01578582
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578582
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578582/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578582/file/Parallel%20assessment%20of%20the%20effects%20of%20bisphenol%20A_accepted.pdf
DOI : 10.1093/humrep/dex093

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Ro 31-8220 is a potent protein kinase C (PKC) inhibitor belonging to the chemical class of bisindolylmaleimides (BIMs). Various PKC-independent effects of Ro 31-8220 have however been demonstrated, including inhibition of the ATP-binding cassette drug transporter breast cancer resistance protein. In the present study, we reported that the BIM also blocks activity of the solute carrier organic cation transporter (OCT) 1, involved in uptake of marketed drugs in the liver, in a PKC-independent manner. Ro 31-8220, in contrast to other pan-PKC inhibitors such as staurosporine and chelerythrine, was thus shown to cis-inhibit uptake of the reference OCT1 substrate tetraethylammonium in OCT1-transfected HEK293 cells in a concentration-dependent manner (IC50 = 0.18 μM) and without altering membrane expression of OCT1. This blockage of OCT1 was also observed in human hepatic HepaRG cells that constitutionally express OCT1. It likely occurred through a mixed mechanism of inhibition. Ro 31-8220 additionally trans-inhibited TEA uptake in OCT1-transfected HEK293 cells, which likely discards a transport of Ro 31-8220 by OCT1. Besides Ro 31-8220, 7 additional BIMs, including the PKC inhibitor LY 333531, inhibited OCT1 activity, whereas 4 other BIMs were without effect. In silico analysis of structure-activity relationships next revealed that various molecular descriptors, especially 3D-WHIM descriptors related to total size, correspond to key physico-chemical parameters for inhibition of OCT1 activity by BIMs. In addition to activity of OCT1, Ro 31-8220 inhibited those of other organic cation transporters such as multidrug and toxin extrusion protein (MATE) 1 and MATE2-K, whereas, by contrast, it stimulated that of OCT2. Taken together, these data extend the nature of cellular off-targets of the BIM Ro 31-8220 to OCT1 and other organic cation transporters, which has likely to be kept in mind when using Ro 31-8220 and other BIMs as PKC inhibitors in experimental or clinical studies
ISSN: 1932-6203

hal-01255837
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01255837
DOI : 10.1371/journal.pone.0144667
PUBMED : 26657401
PUBMEDCENTRAL : PMC4675551

Éditeur(s) : HAL CCSD
Résumé : International audience
The search for safe antimalarial compounds acting against asexual symptom-responsible stages and sexual transmission-responsible forms of Plasmodium species is one of the major challenges in malaria elimination programs. So far, among current drugs approved for human use, only primaquine has transmission-blocking activity. The discovery of small molecules targeting different Plasmodium falcip-arum life stages remains a priority in antimalarial drug research. In this context, several independent studies have recently reported antiplasmodial and transmission-blocking activities of commonly used stains, dyes and fluorescent probes against P. falciparum including chloroquine-resistant isolates. Herein we have studied the antimalarial activities of dyes with different scaffold and we report that the triar-ylmethane dye (TRAM) Brilliant green inhibits the growth of asexual stages (IC 50 2 mM) and has exflagellation-blocking activity (IC 50 800 nM) against P. falciparum reference strains (3D7, 7G8) and chloroquine-resistant clinical isolate (Q206). In a second step we have investigated the antiplasmodial activities of two polysulfonated triarylmethane food dyes. Green S (E142) is weakly active against P. falciparum asexual stage (IC 50 x 17 mM) whereas Patent Blue V (E131) is inactive in both antimalarial assays. By applying liquid chromatography techniques for the culture supernatant analysis after cell washings and lysis, we report the detection of Brilliant green in erythrocytes, the selective uptake of Green S (E142) by infected erythrocytes, whereas Patent Blue V (E131) could not be detected within non-infected and 3D7-infected erythrocytes. Overall, our results suggest that two polysulfonated food dyes might display different affinity with transporters or channels on infected RBC membrane.
International journal for parasitology. Drugs and drug resistance

Droits : http://creativecommons.org/licenses/by-nc-sa/
pasteur-01614675
https://hal-pasteur.archives-ouvertes.fr/pasteur-01614675
https://hal-pasteur.archives-ouvertes.fr/pasteur-01614675/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-01614675/file/Leba%20LJ-article%20colorant-version%20publiee.pdf
DOI : 10.1016/j.ijpddr.2017.07.002

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
Heterocyclic aromatic amines (HAA) are formed in cooked meat, poultry and fish but also arise in tobacco smoke and exhaust gases. HAA are potential human carcinogens, which require metabolic activation to exert their genotoxicity. Human tissues can bioactivate HAA to produce reactive intermediates that bind to DNA. HAA DNA adduct formation occurs in human hepatocytes; however, the potential of HAA to form DNA adducts has not been investigated in human T lymphocytes. In this study, we investigated the ability of human T lymphocytes activated with PMA/Ionomycin or CD3/CD28 to express functional CYP1 activity and bioactivate three major HAA: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-9H-pyrido[2,3-b]indole (AαC) to form DNA adducts. Adducts were measured by ultraperformance liquid chromatography-electrospray ionization/multistage scan mass spectrometry. The highest level of DNA adducts occurred for AαC (16 adducts per 109 nucleotides), followed by PhIP (9 adducts per 109 nucleotides). In contrast, DNA adducts formed from MeIQx and the structurally related aromatic amine 4-aminobiphenyl, a known human carcinogen, were below the limit of detection (< 3 adducts per 109 nucleotides). Moreover, we demonstrate that AαC is a potent inducer of CYP1A1 and CYP1B1 activity through a transcriptional mechanism involving the AhR pathway. Overall, our results highlight the capacity of activated human T lymphocytes to more efficiently bioactivate AαC to form DNA adducts than other prominent HAA or 4-ABP. Environ. Mol. Mutagen. 57:656-667, 2016.
ISSN: 0893-6692

hal-01400486
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01400486
DOI : 10.1002/em.22059
PUBMED : 27801952

Éditeur(s) : UNDP Guyana UNDP Guyana ( Guyana )
Résumé : (Funding) Support for the development of the technical infrastructure and partner training provided by the United States Department of Education TICFIA program.
While the global response to HIV and AIDS has realized several successes in achieving universal access to prevention, care and treatment to date, challenges persist in ensuring equal access to these services for most at risk populations. The epidemiology of HIV reflects a stark disparity in access to prevention and treatment services for neglected most-at risk populations, such as men who have sex with men (MSM). World-wide, MSM often experience higher rates of HIV relative to the total population. The reasons for this dynamic are multi-faceted and include high risk behaviors, and cultural as well as structural barriers. For MSM in developing countries, for example, basic services for prevention and treatment of HIV infection have yet to reach the large majority of men. Homophobia and discrimination limit access of MSM to prevention services and markedly increase vulnerability, as do criminalization of same-sex behavior. Decriminalization of same-sex behavior is a structural intervention for prevention of HIV infection and has recently been embraced by a nonbinding statement from the United Nations (Beyrer C,Clin Infect Dis. 2010 May 15;50 Suppl 3:S108-13) In the Caribbean, all of the above mentioned barriers exist. In fact, recent evidence demonstrates that there is a correlation between the decriminalization of homosexuality and lower rates of HIV (UNAIDS). This correlation is attributed to improved access to services. Therefore, The United Nations Development Program (UNDP) has recently launched an initiative to address the current situation regarding men who have sex with men in Guyana where the HIV prevalence in this population is 19.4% in contrast to 1.8% in the total population. This rapid assessment has been commissioned to supplement two previous studies that were conducted in Guyana in informing the design of upcoming activities to support local capacity building to enhance access to services and respect for the human rights protections for MSM. Unfortunately, in Guyana, like much of the Caribbean, MSM tend to be a hard to reach population, perhaps due to elevated levels of stigma and discrimination and difficulty in accessing men who might participate in high risk same sex behaviors yet do not self-identify as an MSM. As a result, there is a relative paucity of data concerning the knowledge, attitudes and behaviors of this total population in Guyana. (i.e. those who self –identify and those who do not) The baseline report is organized as follows: the methodology is explained followed by the study limitations, the review (literature and desk). The report then proceeds with describing the reality of work and working with sexual and gender minorities in Guyana, the status quo and entry points. The main findings of the capacity assessment and focus groups are then discussed. Issues relating to the uniformed forces and health services providers are then presented followed by discussions and conclusions.

Droits : All rights reserved by the source institution.

Éditeur(s) : HAL CCSD
Résumé : International audience
Smoking is well-known to impair pharmacokinetics, through inducing expression of drug metabolizing enzymes. In the present study, we demonstrated that cigarette smoke condensate (CSC) also alters activity and expression of hepatic drug transporters, which are now recognized as major actors of hepatobiliary elimination of drugs. CSC thus directly inhibited activities of sinusoidal transporters such as OATP1B1, OATP1B3, OCT1 and NTCP as well as those of canalicular transporters like P-glycoprotein, MRP2, BCRP and MATE1, in hepatic transporters-overexpressing cells. CSC similarly counteracted constitutive OATP, NTCP and OCT1 activities in human highly-differentiated hepatic HepaRG cells. In parallel, CSC induced expression of BCRP at both mRNA and protein level in HepaRG cells, whereas it concomitantly repressed mRNA expression of various transporters, including OATP1B1, OATP2B1, OAT2, NTCP, OCT1 and BSEP, and enhanced that of MRP4. Such changes in transporter gene expression were found to be highly correlated to those caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin, a reference activator of the aryl hydrocarbon receptor (AhR) pathway, and were counteracted, for some of them, by siRNA-mediated AhR silencing. This suggests that CSC alters hepatic drug transporter levels via activation of the AhR cascade. Importantly, drug transporter expression regulations as well as some transporter activity inhibitions occurred for a range of CSC concentrations similar to those required for inducing drug metabolizing enzymes and may therefore be hypothesized to be relevant for smokers. Taken together, these data established human hepatic transporters as targets of cigarette smoke, which could contribute to known alteration of pharmacokinetics and some liver adverse effects caused by smoking. © 2016 Elsevier Ireland Ltd
Toxicology

hal-01367143
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367143
DOI : 10.1016/j.tox.2016.07.011
PUBMED : 27450509

Éditeur(s) : HAL CCSD European Geosciences Union (EGU)
Résumé : International audience
Pollen and clay mineralogical analyses of a Holocene sequence from Sebkha Boujmel (southern Tunisia) traces the climatic and environmental dynamics in the lower arid bioclimatic zone over the last 8000 years. During the Mid- to Late Holocene transition, between 8 and 3 ka, a succession of five wet/dry oscillations is recorded. An intense arid event occurs between 5.7 and 4.6 ka. This episode marks the onset of a long-term aridification trend with a progressive retreat of Mediterranean woody xerophytic vegetation and of grass steppes. It ends with the establishment of pre-desert ecosystems around 3 ka. The millennial-scale climate change recorded in the data from Sebkha Boujmel is consistent with records from the south and east Mediterranean, as well as with climatic records from the desert region for the end of the African Humid Period (AHP). Eight centennial climatic events are recorded at Sebkha Boujmel and these are contemporary with those recorded in the Mediterranean and in the Sahara. They indicate a clear coupling between the southern Mediterranean and the Sahara before 3 ka. The event at 4.2 ka is not evidenced and the link between events recorded in Sebkha Boujmel and the North Atlantic Cooling events is clearer from 3 ka onwards. These variations indicate the importance of climatic determinism in the structuring of landscapes, with the establishment of the arid climatic conditions of the Late Holocene. It is only from 3 ka onwards that the dynamic of plant associations is modified by both human activity and climatic variability. The climatic episodes identified during the historic period indicate strong regionalisation related to the differential impact of the North Atlantic Oscillation (NAO) and the Mediterranean Oscillation (MO) on the Mediterranean basin. The local human impact on regional ecosystems is recorded in the form of episodes of intensification of pastoral and/or agricultural activities. The development of olive production and of several taxa associated with agriculture attest to increasing sedentism among human populations during Classical Antiquity. The significant increase in Artemisia (wormwood) between 1.1 and 0.8 ka (850–1150 AD) is linked to intensive pastoral activity, associated with heightened interannual and/or seasonal climatic instability. A complete re-shaping of the landscape is recorded during the 20th century. The remarkable expansion of the olive tree, and the deterioration of regional ecosystems with the spread of desert species, is linked to recent local socio-economic changes in Tunisia.
ISSN: 1814-9324

hal-01319967
https://hal.archives-ouvertes.fr/hal-01319967
https://hal.archives-ouvertes.fr/hal-01319967/document
https://hal.archives-ouvertes.fr/hal-01319967/file/cp-12-1339-2016.pdf
DOI : 10.5194/cp-12-1339-2016

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND: The aryl hydrocarbon receptor (AhR) has gradually emerged as a regulator of inflammation in the lung and other tissues. AhR may interact with the p65-subunit of the nuclear factor (NF)-κB transcription factors, but reported outcomes of AhR/NF-κB-interactions are conflicting. Some studies suggest that AhR possess pro-inflammatory activities while others suggest that AhR may be anti-inflammatory. The present study explored the impact of AhR and its binding partner AhR nuclear translocator (Arnt) on p65-activation and two differentially regulated chemokines, CXCL8 (IL-8) and CCL5 (RANTES), in human bronchial epithelial cells (BEAS-2B). RESULTS: Cells were exposed to CXCL8- and CCL5-inducing chemicals, 1-nitropyrene (1-NP) and 1-aminopyrene (1-AP) respectively, or the synthetic double-stranded RNA analogue, polyinosinic-polycytidylic acid (Poly I:C) which induced both chemokines. Only CXCL8, and not CCL5, appeared to be p65-dependent. Yet, constitutively active unligated AhR suppressed both CXCL8 and CCL5, as shown by siRNA knock-down and the AhR antagonist α-naphthoflavone. Moreover, AhR suppressed activation of p65 by TNF-α and Poly I:C as assessed by luciferase-assay and p65-phosphorylation at serine 536, without affecting basal p65-activity. In contrast, Arnt suppressed only CXCL8, but did not prevent the p65-activation directly. However, Arnt suppressed expression of the NF-κB-subunit RelB which is under transcriptional regulation by p65. Furthermore, AhR-ligands alone at high concentrations induced a moderate CXCL8-response, without affecting CCL5, but suppressed both CXCL8 and CCL5-responses by Poly I:C. CONCLUSION: AhR and Arnt may differentially and independently regulate chemokine-responses induced by both inhaled pollutants and pulmonary infections. Constitutively active, unligated AhR suppressed the activation of p65, while Arnt may possibly interfere with the action of activated p65. Moreover, ligand-activated AhR suppressed CXCL8 and CCL5 responses by other agents, but AhR ligands alone induced CXCL8 responses when given at sufficiently high concentrations, thus underscoring the duality of AhR in regulation of inflammation. We propose that AhR-signaling may be a weak activator of p65-signaling that suppresses p65-activity induced by strong activators of NF-κB, but that its anti-inflammatory properties also are due to interference with additional pathways.
Cell communication and signaling: CCS

hal-01063555
https://hal.archives-ouvertes.fr/hal-01063555
DOI : 10.1186/s12964-014-0048-8

Éditeur(s) : HAL CCSD
Résumé : International audience
The French education system remains highly centralized and only allows limited local adaptations for overseas territories. For example, if some laws (the last in 2013) allow the use of regional languages (e.g. Creole in the French West Indies) when they constitute a relevant contribution to the teaching, many official texts remain mainly based on the geographical, economical, historical, environment of the French mainland. We focus on some French BTS (Brevet de Technicien Supérieur / Advanced Technician Certificate), namely tourism and assistant manager, which are two important diplomas for the local development and in which microeconomic and management sciences plays a great part. The French BTS is a professional diploma prepared in two years after the “baccalauréat”, with national programs and evaluation criteria. The successful candidates are supposed to be immediately employable, especially in their local geographical environment. Thus, there exists a paradox between the national definition of the diploma and the local contexts of teaching. We discuss how teachers concretely deal with this situation on a day-to-day basis. Our hypothesis is that they act pragmatically, using their practical pedagogical content knowledge, without theoretical support for their action. In order to verify this hypothesis, we have conducted semi-structured interview with Guadeloupian teachers of the two aforementioned BTS. The main results shows that teachers adapt the national framework of the diploma, essentially by using local examples. This can be called a weak contextualization of the national texts. Indeed, these adaptations remain limited by fear of disadvantaging the students for the national exam. In addition, many context effects are shown, for example linked with local rules (concerning VAT, custom duties...) which are only partially taken into account by teachers. This demonstrates that the French educative system has not yet completely solved the opposition between national guideline and decentralization of the educational action.
19th General Meeting and Biennial Conference “Harnessing Science and Technology to create knowledge-base Economies and preserve Caribbean Ecosystems”
Tobago, Trinidad and Tobago

hal-01535045
https://hal.univ-antilles.fr/hal-01535045

Éditeur(s) : HAL CCSD
Résumé : International audience
In all vertebrate species, estrogens play a crucial role in the development, growth, and function of reproductive and nonreproductive tissues. A large number of natural or synthetic chemicals present in the environment and diet can interfere with estrogen signaling; these chemicals are called endocrine disrupting chemicals (EDCs) or xenoestrogens. Some of these compounds have been shown to induce adverse effects on human and animal health, and some compounds are suspected to contribute to diverse disease development. Because xenoestrogens have varying sources and structures and could act in additive or synergistic effects when combined, they have multiple mechanisms of action. Consequently, an important panel of in vivo and in vitro bioassays and chemical analytical tools was used to screen, evaluate, and characterize the potential impacts of these compounds on humans and animals. In this paper, we discuss different molecular actions of some of the major xenoestrogens found in food or the environment, and we summarize the current models used to evaluate environmental estrogens.
Int J Endocrinol

Droits : info:eu-repo/semantics/OpenAccess
inserm-00863365
http://www.hal.inserm.fr/inserm-00863365
http://www.hal.inserm.fr/inserm-00863365/document
http://www.hal.inserm.fr/inserm-00863365/file/501851.pdf
PUBMED : 23737774

Éditeur(s) : HAL CCSD
Résumé : International audience
Nous décrivons une recherche-action déclinant des processus de conception en univers organisationnel complexe. Une perspective stratégique se dévoile par la présence de partenaires d’affaires réfléchissant collectivement. Le dispositif évoque l’idée de lieu de rencontres structurant au sein duquel des acteurs font des échanges. En situation d’observation participante inscrite dans le projet de changement de l’organisation étudiée, nous sommes agent interne de changement, intervenante et observatrice de ce qui se passe, y compris de notre propre action, de façon à garder le double niveau de réflexivité du praticien (Schön, 1993). Le but de notre recherche est de considérer cette situation de management et de nous demander comment l’analyser. Doit-on l’envisager comme un dispositif original? Peut-on en construire une théorie et en faire un modèle original d’action collective?Nous postulons qu’il existe un modèle de fabrique de la stratégie sous une forme actionnable afin d’en faire la modélisation théorique donnant à ce modèle sa valeur générale (David, Hatchuel, 2007). Nous ne testons pas une théorie pré-existante sur une situation empirique. Nous faisons l’hypothèse que le cas est suffisamment riche pour déterminer s’il correspond à un modèle d’action originale.Nous aboutissons à l’hypothèse que celui-ci serait une plateforme de conception de la stratégie en même temps qu’un lieu contributeur au fonctionnement d’un écosystème d’affaires central dans ce dispositif.
84e congrès de l'Association Francophone pour le Savoir (ACFAS)e congrès de l'Association Francophone pour le Savoir (ACFAS)
MONTREAL, Canada

hal-01314739
https://hal.archives-ouvertes.fr/hal-01314739

Éditeur(s) : HAL CCSD European Geosciences Union (EGU)
Résumé : International audience
Holocene climate fluctuations and human activity since the Neolithic have shaped present-day Mediter-ranean environments. Separating anthropogenic effects from climatic impacts to better understand Mediterranean pale-oenvironmental changes over the last millennia remains a challenging issue. High-resolution pollen analyses were un-dertaken on two cores from the Palavasian lagoon system (Hérault, southern France). These records allow reconstruction of vegetation dynamics over the last 4500 years. Results are compared with climatic, historical and archeological archives. A long-term aridification trend is highlighted during the late Holocene, and three superimposed arid events are recorded at 4600–4300, 2800–2400 and 1300–1100 cal BP. These periods of high-frequency climate variability coincide in time with the rapid climatic events observed in the Atlantic Ocean (Bond et al., 2001). From the Bronze Age (4000 cal BP) to the end of the Iron Age (around 2000 cal BP), the spread of sclerophyllous taxa and loss of forest cover result from anthropogenic impact. Classical Antiquity is characterized by a major reforestation event related to the concentration of rural activity and populations in coastal plains leading to forest recovery in the mountains. A major regional deforestation occurred at the beginning of the High Middle Ages. Around 1000 cal BP, forest cover is minimal while the cover of olive, chestnut and walnut expands in relation to increasing human influence. The present-day vegetation dominated by Mediterranean shrubland and pines has been in existence since the beginning of the 20th century.
ISSN: 1814-9324

hal-01447627
https://hal-univ-tlse2.archives-ouvertes.fr/hal-01447627
https://hal-univ-tlse2.archives-ouvertes.fr/hal-01447627/document
https://hal-univ-tlse2.archives-ouvertes.fr/hal-01447627/file/Azuara%20et%20al%202015_cor.pdf
DOI : 10.5194/cp-11-1769-2015

Éditeur(s) : HAL CCSD
Résumé : International audience
Chaque pratique professionnelle, chaque métier a son langage. Le métier d’enseignant n’échappe pas à ce processus de construction d’une sémiotique qui, à la fois, construit une pratique et se trouve inévitablement construite par cette dernière. Les gestes d’un expert pratique ne se réduisent pas aux actions qui les manifestent, ils signifient. Ils représentent la forme discursive et symbolique d’actions et de pouvoir-savoir (Foucault, 1969) au sein d’une pratique culturellement et socialement identifiée. L’expert, par sa pratique, ses gestes de corps, ses dires, contribue à l’ethnohistoire de sa pratique. Comment un enseignant perçoit-il ses actes d’intervention et en particulier son acte de formation? Dans quel univers sémiotique son expérience d’enseignant et/ou de formateur se manifeste-t-elle, se construit-elle ?Nous avons entamé au sein de notre laboratoire, un programme de recherches consacré à la sémiotique des pratiques sportives et des pratiques d’éducation et de formation sur le sens et les significations que donnent, à leurs actes professionnels, les enseignants et les formateurs. Cela nous conduit à prendre en compte la part subjective du sujet dans le processus d’élaboration et de réalisation de ses actes, en employant des méthodes qualitatives utilisant en particulier les techniques vidéo de rappel stimulé (Tochon, FV. 2002) les dispositifs d’auto-confrontation (Clot Y., 2000) et/ou d’explicitation (Vermersch P. ,1994) ou encore d’histoire de vie (Pineau ,G. 1998). Nous avons mis au point un dispositif de formation- recherche plus particulièrement consacré l’ imaginaire des praticiens à propos de leurs actes d’intervention. Il s’appuie sur un outil de stimulation projective, le photolangage, pratiqué dans le cadre d’une problématique de formation publiée par ailleurs (Alin C. , 1996). La recherche porte sur une étude comparée du choix ordonné par ordre décroissant de préférence de cinq photos sur 20 et des jugements discursifs, écrits et argumentatifs, portés rationnellement sur ces choix, à propos de l’acte professionnel : “ former? ”. Nous présentons deux études comparatives du sens et des significations donnés à l’acte “ former ” par des praticiens expérimentés et/ou de futurs praticiens.La première concerne un échantillon représentatif d’experts et de novices en Education Physique et Sportive. Nous avons analysé chacune des photos choisies et chacun des jugements arguemtatifs qui leur étaient affectés, en puisant principalement nos fondements théoriques dans les travaux précurseurs de sémiotique de C.S. Peirce (1979), ceux de la théorie sémiocognitive et expérientielle de Lakoff G. & Johnson M. (1980, 1985), ainsi que dans les travaux d’analytique du langage de Coursil J. (2000), en matière de dialogue et de communication, Sur le plan méthodologique, nous avons travaillé sur les trois registres évoqués dans notre protocole de recherche (sémantique, sémiotique, symbolique) pour établir trois types de documents d’analyse : une carte sémiotique par photos choisies ; trois réseaux sémiotiques (Novices, Experts, Communauté EPS) ; des profils sémiotiques collectifs et individuels. La deuxième étude, actuellement en cours d’analyse, a pour but de comparer, avec le même protocole, des étudiants français de l’Université des Antilles et de la Guyane et des étudiants américains de l’Université de Madison (Wisconsin USA). Elle devrait nous donner quelques indications sur des aspects interculturels quant à la perception imaginaire de l’acte de former par des étudiants de culture différente se destinant à la formation. Sur les plans épistémologique, théorique et méthodologique, nous interrogeons les rapports étroits de sémiotique, de culture et de logique qui lient langage et images, perception et action, langage et action, langage et identité à propos d’un acte professionnel “ former? ” et de l’ethno- histoire d’une pratique.
8ème Congrès de l’Association Internationale de Sémiotique, Université de Lyon 2
Lyon, France

hal-01613692
https://hal.univ-antilles.fr/hal-01613692

Éditeur(s) : HAL CCSD
Résumé : In 1996 the European Commission Humanitarian Office (ECHO) launched a regional approach for disaster preparedness, focusing in its first phase on Central America, Caribbean and Southeast Asia (including Bangladesh). The first step in this process was the preparation of a «diagnostic study» that involved a situation review of the countries in these regions with regard to their vulnerabilities, disaster preparedness capacities and national plans or policies for disaster management.The Centre for Research on the Epidemiology of Disasters of the Université Catholique de Louvain (UCL) served as ECHO’s principal technical support with the collaboration of other institutions in Europe and the regions.The present «diagnostic report», covering Central America and the Caribbean, has been carried out by the Centre International pour la Formation et les Echanges en Géosciences (CIFEG) under the supervision of Professor Robert D’Ercole (Université de Savoie, Chambéry).Mr. Thierry Lesales (Université des Antilles et de la Guyane) participated closely in the drafting of this report and was actively involved in the field missions with Mr D’Ercole where they met and interviewed numerous national officials, non-governmental organisations and regional and international bodies. Further assistance was provided by Claudine Misson (CRED) for the interviews and information collected in the Dominican Republic. The report also draws from an earlier mission undertaken by Dr. Philippe Masure (BRGM, France), Christian Bugnion (CRED) and Alexandra Angulo (CRED) who undertook some of the preparatory work for the diagnostic study.This report presents an analysis of the disaster preparedness situation in Central America and the Caribbean and provides some preliminary recommendations regarding priorities and future programme direction. As such it remains primarily a descriptive study. It is expected to form the basis for the formulation of the ECHO Disaster Preparedness Action Plan.
En 1996, la Oficina Humanitaria de la Comunidad Europea (ECHO) lanzó la iniciativa de un enfoque regional en materia de preparación a los desastres, concentrándose inicialmente en las regiones de América Central, Caribe y Asia del Sureste (incluyendo a Bangladesh). La primera fase de este proceso fue la preparación de un « diagnóstico» que implicaba un examen de la situación de los países de cada una de estas regiones en relación a la vulnerabilidad, la capacidad de preparación a los desastres y las políticas y planes nacionales en materia de gestión de desastres.El Centre for Research on the Epidemiology of Disasters (CRED), de la Université Catholique de Louvain (UCL), ha sido el principal apoyo técnico de ECHO para esta iniciativa, con la colaboración y asistencia de otras instituciones en Europa y en las regiones arriba mencionadasEl presente informe que cubre América Central y el Caribe, fue realizado por el International Centre for Training and Exchanges in Geosciences (CIFEG), bajo la dirección del Profesor Robert D'Ercole (Université de Savoie).Thierry Lesales (Université des Antilles et de la Guyane) participó de cerca a la realización de este documento y estuvo activamente implicado junto al Profesor D'Ercole en las misiones que se realizaron en varios países. En el curso de estas misiones, se entrevistaron con numerosos representantes de gobiernos nacionales, de ONGs y de organizaciones regionales e internacionales Se contó igualmente con la asistencia de Claudine Misson (CRED), quien realizó la misión en República Dominicana. El informe se basa igualmente en una misión anterior llevada a cabo por Philippe Masure (BRGM, France), Alexandra Angulo (CRED) y Christian Bugnion (CRED), la cual realizó parte del trabajo preparatorio para el diagnóstico.El informe presenta un análisis de la situación en América Central y el Caribe y provee recomendaciones preliminares para las prioridades y dirección del futuro programa. En el marco de la segunda fase, está destinado a servir de base para la formulación del Plan de Acción de Preparación a los Desastres de ECHO.
Depuis 1994, ECHO (Office Humanitaire de la Commission Européenne, devenu le service de la Commission européenne à l’aide humanitaire et à la protection civile) a financé, à l'échelle mondiale, de nombreuses opérations pour la prévention et la préparation aux catastrophes (catastrophes naturelles principalement) Ces financements ont répondu aux demandes d'ONG et d'organisations internationales qui ont-elles-mêmes mis en oeuvre les projets correspondants. Les évaluations de ces opérations ont donné des appréciations positives. Cependant, ECHO souhaite s'impliquer davantage dans la prévention et la préparation aux catastrophes et mieux cibler ses actions pour une plus grande cohérence d'ensemble.Au cours de la réunion du 16 juillet 1996, le Comité d'Aide Humanitaire a approuvé la nouvelle approche régionale proposée par ECHO pour son programme de prévention, d'atténuation et de préparation aux catastrophes, le DIPECHO (Dlsaster Preparedness ECHO), pour la période 1996—1998. Ce programme doit s'appliquer dans un cadre régional en concentrant d'abord ses financements sur des plans d'action dans les Caraïbes, en Amérique Centrale, en Asie du Sud-Est et au Bangladesh. Par ailleurs, au lieu de répondre exclusivement aux demandes de financements spécifiques d'ONG, d'organisations internationales et de gouvernements, ECHO souhaite préparer des plans d'action et déterminer les partenaires les plus appropriés pour une mise en oeuvre dirigée par ECHO même. En outre, le DIPECHO a pour objet de rendre plus efficace l'action de l'ensemble de l'Union Européenne, par une étroite coordination de son action avec celles de la Commission et des Etats Membres. Il est enfin prévu de faire précéder la préparation des plans d'action par une phase de diagnostic au cours de laquelle seront identifiés, pour chaque région, les risques, les structures et politiques de prévention existantes aux niveaux communautaire, national et régional, ainsi que les appuis extérieurs en cours et à venir. L'objectif est non seulement de déterminer les lacunes, mais également d'évaluer la cohérence et l'efficacité des systèmes de réponse dans leur ensemble......Dans ce contexte, une première mission exploratoire a été réalisée du 30 septembre au 12 octobre 1996 dans les Caraïbes et l'Amérique Centrale (quatre pays visités) et a débouché sur un premier rapport (A. Angulo, Ch. Bugnion, Ph. Masure, "Rapport de mission exploratoire dans les Caraïbes ct en Amérique Centrale pour DIPECHO").Ce rapport apporte de nombreuses informations et en particulier:(1) il définit le cadre conceptuel, insistant, à juste titre, sur le fait que la prévention et la préparation doivent être distinguées de l'aide d'urgence et qu'elles font partie d'un processus continu au même titre que le développement ;(2) il présente les principales organisations régionales et internationales, et leurs activités dans le domaine de la prévention et de la préparation;(3) il met en évidence les grands types de besoins et fournit les premières orientations pour le programme DIPECHO......Le présent rapport, constituant le diagnostic proprement dit, fait suite à une deuxième série de missions effectuées dans la même région. Il vise à compléter les apports de la mission exploratoire, notamment par:(a) une analyse des catastrophes et de leurs conséquences:(b) une évaluation comparée des risques dans la région;(c) une analyse détaillée des réalisations et des besoins en matière de réduction des risques et des conséquences des catastrophes naturelles ;(d) un examen des conditions actuelles pour un programme DIPECHO cohérent, réalisable et efficace, avec, en particulier, la prise en compte de l’organisation actuelle de la prévention et de la préparation dans la région et un état des appuis extérieurs ;- des propositions de lignes d'actions prioritaires pour le DIPECHO......Le diagnostic s'est appuyé sur une importante documentation : travaux scientifiques, études et rapports recueillis auprès du CRED-Université Catholique de Louvain, du CIFEG, du DHA, de l’IDNDR, de divers organismes sur le terrain (notamment le centre de documentation de San José au Costa Rica), et d'universités européennes (Université de Savoie. Chambéry, Université de Lausanne). Mais ce sont avant tout les nombreux entretiens menés lors des missions (près de 200) qui ont donné corps au diagnostic.Treize pays Ont été visités entre le 22/01 et le 07/03/1997 :- République Dominicaine (C Misson);- Costa Rica, Guatemala, Nicaragua et Cuba (R. D'Ercole) ;- Antigua, Barbade, Haïti, Jamaïque, Ste-Lucie, St-Maarten, St-Vincent et le Guyana (Th. Lesales).Leur choix a été déterminé en concertation avec ECHO, le CRED-UCL et le CIFEG. Ils ne recouvrent pas l'ensemble des pays qu'il aurait été théoriquement possible de visiter. Cependant, le choix de pays-clés, les contacts établis avec de nombreux organismes de portée régionale et la documentation consultée, ont permis de bâtir un diagnostic d'ensemble......L'étude comporte trois parties.La 1e partie constitue une analyse des catastrophes en termes de bilan et de risque. Il s'agit, à l'aide de cartes, notamment, de montrer les effets des catastrophes naturelles en Amérique Centrale et dans les Caraïbes, de présenter la répartition et la fréquence des aléas naturels et de procéder à une analyse de critères de vulnérabilité. L'objectif est, enfin, de déterminer des niveaux de risque, à l'échelle de la région, compte tenu des dangers naturels et des critères de vulnérabilité.La 2° partie est l'étude des actions entreprises dans la région, ces dernières années, afin de réduire les risques et les conséquences des catastrophes. Cette étude permet de dégager des lacunes et des besoins. Les différentes composantes entrant dans le processus de réduction des catastrophes sont retenues : recherche scientifique et technique, prévention stricto sensu, préparation, information / formation. L'accent est également placé sur les modes actuels d'application des politiques de réduction des risques : de l'approche sectorielle à l'approche intégrée.La 3e partie traite des conditions actuelles pour la mise en oeuvre d'un programme DIPECHO cohérent et efficace. Quatre aspects fondamentaux sont analysés: les particularités régionales et nationales (l'hétérogénéité et ses conséquences); les faiblesses et qualités institutionnelles aux différents échelons géographiques: les caractéristiques des organismes susceptibles de contribuer à la mise en oeuvre du DIPECHO; le rôle actuel et en perspective de la Communauté Européenne et des Etats Membres.Chaque partie comporte une conclusion partielle La conclusion générale reprend les idées force des conclusions intermédiaires ct débouche sur des lignes d'actions prioritaires recommandées pour le DIPECHO......L'étude confiée au CIFEG par le CRED-UCL et ECHO a été coordonnée par Robert D'Ercole (Département de Géographie, Université de Savoie, Chambéry, France). Elle a bénéficié de la collaboration de Thierry Lesales (Département de Géographie, Université des Antilles et de la Guyane, Martinique, France) et de Patrick Pigeon (Département de Géographie, Université de Savoie, Chambéry, France). Ont également contribué à la réalisation de celle étude: Claudine Misson (CRED-UCL, Belgique), Jean-Claude Napias (CIFEG, directeur), Jacques Giri (CIFEG, président), Sylvie Orlyk (CIFEG, secrétariat).
https://hal.archives-ouvertes.fr/hal-01196496

hal-01196496
https://hal.archives-ouvertes.fr/hal-01196496
https://hal.archives-ouvertes.fr/hal-01196496/document
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