Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
We carried out morphotectonic studies along the left-lateral strike-slip Bogd Fault, the principal structure involved in the Gobi-Altay earthquake of 1957 December 4 (published magnitudes range from 7.8 to 8.3). The Bogd Fault is 260 km long and can be subdivided into five main geometric segments, based on variation in strike direction. West to East these segments are, respectively: the West Ih Bogd (WIB), The North Ih Bogd (NIB), the West Ih Bogd (WIB), the West Baga Bogd (WBB) and the East Baga Bogd (EBB) segments. Morphological analysis of offset streams, ridges and alluvial fans-particularly well preserved in the arid environment of the Gobi region-allows evaluation of late Quaternary slip rates along the different faults segments. In this paper, we measure slip rates over the past 200 ka at four sites distributed across the three western segments of the Bogd Fault. Our results show that the left-lateral slip rate is similar to 1 mm yr(-1) along the WIB and EIB segments and similar to 0.5 mm yr(-1) along the NIB segment. These variations are consistent with the restraining bend geometry of the Bogd Fault.;Our study also provides additional estimates of the horizontal offset associated with the 1957 earthquake along the western part of the Bogd rupture, complementing previously published studies. We show that the mean horizontal offset associated with the 1957 earthquake decreases progressively from 5.2 m in the west to 2.0 m in the east, reflecting the progressive change of kinematic style from pure left-lateral strike-slip faulting to left-lateral-reverse faulting. Along the three western segments, we measure cumulative displacements that are multiples of the 1957 coseismic offset, which may be consistent with a characteristic slip. Moreover, using these data, we re-estimate the moment magnitude of the Gobi-Altay earthquake at M-w 7.78-7.95.;Combining our slip rate estimates and the slip distribution per event we also determined a mean recurrence interval of similar to 2500-5200 yr for past earthquakes along the different segments of the western Bogd Fault. This suggests that the three western segments of the Bogd Fault and the Gurvan Bulag thrust fault (a reverse fault bounding the southern side of the Ih Bogd range that ruptured during the 1957 earthquake) have similar average recurrence times, and therefore may have ruptured together in previous earthquakes as they did in 1957. These results suggest that the western part of the Bogd Fault system, including the Gurvan Bulag thrust fault, usually behaves in a 'characteristic earthquake' mode.
ISSN: 0956-540X

hal-00639467
https://hal.archives-ouvertes.fr/hal-00639467
https://hal.archives-ouvertes.fr/hal-00639467v2/document
https://hal.archives-ouvertes.fr/hal-00639467/file/rizzaGJI2011.pdf
DOI : 10.1111/j.1365-246X.2011.05075.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A dense, local network of 30 geodetic markers covering a 50 × 60 km2 area in the southwestern European Alps (Briançon region) has been temporarily surveyed in 1996, 2006 and 2011 by GPS. The aim is to measure the current deformation in this seismically active area. The study zone is characterized by a majority of extensional and dextral focal mechanisms, along north–south to N160 oriented faults. The combined analysis of the three measurement campaigns over 15 years and up to 16 years of permanent GPS data from the French RENAG network now enables to assess horizontal velocities below 1 mm/year within the local network. The long observation interval and the redundancy of the dense campaign network measurement help to constrain a significant local deformation pattern in the Briançon region, yielding an average E–W extension of 16 ± 11 nanostrain/year. We compare the geodetic deformation field to the seismic deformation rate cumulated over 37 years, and obtain good coherencies both in amplitude and direction. Moreover, the horizontal deformation localized in the Briançon region represents a major part of the Adriatic-European relative plate motion. However, the average uplift of the network in an extensional setting needs the presence of buoyancy forces in addition to plate tectonics.
ISSN: 0264-3707

hal-01119724
https://hal.archives-ouvertes.fr/hal-01119724
DOI : 10.1016/j.jog.2015.02.001

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
In places where sedimentation and erosion compete at fast rates, part of the record of past earthquakes on faults may be buried, hence hidden, in the first few metres below the surface. We developed a novel form of palaeoseismology, of geophysical type, based on the use of a dense pseudo-3-D Ground Penetrating Radar (GPR) survey to investigate such possible buried earthquake traces, on a long, fast-slipping strike-slip fault (Hope fault, New Zealand), at a site (Terako) where marked alluvial conditions prevail. We first used LiDAR data to analyse the ground surface morphology of the 2 km2 site at the greatest resolution. Nineteen morphological markers were observed, mainly alluvial terrace risers and small stream channels that are all dextrally offset by the fault by amounts ranging between 3 and 200 m. The measurements document about 10 past earthquake slip events with a mean coseismic slip of 3.3 +/- 1 m, with the most recent earthquake event having a slip of 3 +/- 0.5 m. We then investigated a detailed area of the site (400 x 600 m2) with pseudo-3-D GPR. We measured 56, similar to 400 m long, 510 m spaced GPR profiles (250 MHz), parallel to the fault and evenly distributed on either side. The analysis revealed the existence of a palaeosurface buried at about 3 m depth, corresponding to the top of alluvial terraces of different ages. That buried surface is incised by a dense network of stream channels that are all dextrally offset by the fault. We measured 48 lateral offsets in the buried channel network, more than twice than at the surface. These offsets range between 6 and 108 m, as observed at the surface, yet provide a more continuous record of the fault slip. The similarity of the successive slip increments suggests a slip per event averaging 4.4 +/- 1 m, fairly similar to that estimated from surface data. From the total surface and buried 67 offset collection, we infer that a minimum of 30 large earthquakes have broken the Hope fault at the Terako site in the last about 67 kyr, with an average coseismic slip of 3.2 +/- 1 m, a minimum average recurrence time of about 200 yr, and a magnitude of at least Mw 7.07.4. Our study therefore confirms that part of the record of past earthquakes may indeed reside in the first few metres below the surface, where it may be explored with geophysical, GPR-based palaeoseismology. Developing such a new palaeoseismological tool should provide rich information that may complement surface observations and help to document the past earthquakes on faults.
ISSN: 0956-540X

hal-00704560
https://hal.archives-ouvertes.fr/hal-00704560
DOI : 10.1111/j.1365-246X.2012.05366.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study addresses the mechanical and chemical behavior of allanite during shear zone formation under high-pressure metamorphism. Understanding physico-chemical processes related to the retention or resetting of Pb isotopes in allanite during geological processes is essential for robust petrochronology. Dating of allanite in meta-granodiorite showing variable amounts of strain (from an undeformed protolith to mylonite) at Monte Mucrone (Sesia Zone, NW Italy) gave surprising results. Based on structural and petrographic observations the shear zones at Mt Mucrone are Alpine, yet allanite located within an eclogite facies mylonite yielded Permian ages (208Pb/232Th average age: 287 ± 7 Ma). These mm-sized allanite grains are rimmed by an aggregate of coarse-grained garnet + phengite, thought to derive from former epidote. These aggregates were immersed in a weak matrix that experienced granular flow, and they were thus chemically and mechanically shielded during Alpine mylonitization. In undeformed samples (8a and 8b), two populations of epidote group minerals were found. Allanite forms either coronas around Permian monazite or individual grains with patchy zoning. Both types yield Permian ages (208Pb/232Th age: 291 ± 5 Ma). On the other hand, grains of REE-rich clinozoisite of Cretaceous age are found in undeformed rocks. These grains appear as small fragments with embayed surface outlines and minute satellites or rims around Permian allanite. These (re)crystallized grains are Sr-rich and show mosaic zoning. These results indicate that allanite crystals retained their chemical and isotopic characteristics, and thus their Permian age, as a result of strong strain partitioning between the epidote group porphyroclasts and the eclogite facies matrix in HP-mylonites. The observed partial mobilization of Pb isotopes, which lead to the Cretaceous-aged rims or grains in undeformed samples was facilitated by (re)crystallization of allanite and not by mere Pb diffusion alone under the HP conditions.
ISSN: 0024-4937

insu-00679730
https://hal-insu.archives-ouvertes.fr/insu-00679730
DOI : 10.1016/j.lithos.2011.01.005

Éditeur(s) : HAL CCSD
International Conference on Mechanisms of Mesozoic Continental Extension in Eastern Eurasia
Orléans, France

insu-00610112
https://hal-insu.archives-ouvertes.fr/insu-00610112

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD springer Link
Résumé : International audience
Experimental Astronomy

hal-01094521
https://hal.archives-ouvertes.fr/hal-01094521
BIBCODE : 2014ExA...tmp...41R
DOI : 10.1007/s10686-014-9383-4
ARXIV : 1310.0696

Éditeur(s) : HAL CCSD Wiley
Résumé : [b]1.[/b] Plant functional traits, in particular specific leaf area (SLA), wood density and seed mass, are often good predictors of individual tree growth rates within communities. Individuals and species with high SLA, low wood density and small seeds tend to have faster growth rates.[br/][br/][b]2.[/b] If community-level relationships between traits and growth have general predictive value, then similar relationships should also be observed in analyses that integrate across taxa, biogeographic regions and environments. Such global consistency would imply that traits could serve as valuable proxies for the complex suite of factors that determine growth rate, and, therefore, could underpin a new generation of robust dynamic vegetation models. Alternatively, growth rates may depend more strongly on the local environment or growth–trait relationships may vary along environmental gradients.[br/][br/][b]3.[/b] We tested these alternative hypotheses using data on 27 352 juvenile trees, representing 278 species from 27 sites on all forested continents, and extensive functional trait data, 38% of which were obtained at the same sites at which growth was assessed. Data on potential evapotranspiration (PET), which summarizes the joint ecological effects of temperature and precipitation, were obtained from a global data base.[br/][br/][b]4.[/b] We estimated size-standardized relative height growth rates (SGR) for all species, then related them to functional traits and PET using mixed-effect models for the fastest growing species and for all species together.[br/][br/][b]5.[/b] Both the mean and 95th percentile SGR were more strongly associated with functional traits than with PET. PET was unrelated to SGR at the global scale. SGR increased with increasing SLA and decreased with increasing wood density and seed mass, but these traits explained only 3.1% of the variation in SGR. SGR–trait relationships were consistently weak across families and biogeographic zones, and over a range of tree statures. Thus, the most widely studied functional traits in plant ecology were poor predictors of tree growth over large scales.[br/][br/][b]6.[/b] Synthesis. We conclude that these functional traits alone may be unsuitable for predicting growth of trees over broad scales. Determining the functional traits that predict vital rates under specific environmental conditions may generate more insight than a monolithic global relationship can offer.
ISSN: 0022-0477

hal-01204226
https://hal.archives-ouvertes.fr/hal-01204226
DOI : 10.1111/1365-2745.12401
PRODINRA : 307144

Éditeur(s) : HAL CCSD American Society for Microbiology
Résumé : International audience
Anti-Aspergillus IgG antibodies are important biomarkers for the diagnosis of chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA). We compared the performance of a new commercial EIA (Bordier Affinity Products) with those of the Bio-Rad and VirionSerion EIAs. This assay is novel in the association of two recombinant antigens with somatic and metabolic antigens of A. fumigatus. In a prospective multicentre study, 436 serum samples from 147 patients diagnosed with CPA (136 sera/104 patients) or ABPA (94 sera/43 patients) and from 205 controls (206 sera) were tested. We obtained sensitivities of 97%, 91.7%, and 86.1%, and specificities of 90.3%, 91.3%, and 81.5% for the Bordier, Bio-Rad and VirionSerion tests, respectively. The Bordier kit was more sensitive than the Bio-Rad kit (p < 0.01), which was itself more sensitive than the VirionSerion kit (p=0.04). The Bordier and Bio-Rad kits had similar specificities (p=0.8), both higher than that of the VirionSerion kit (p=0.02). The areas under the ROC curves confirmed the superiority of the Bordier kit over the Bio-Rad and the VirionSerion kits (0.977, 0.951 and 0.897, respectively; p < 0.01 for each comparison). In a subset analysis of 279 sera tested with the Bordier and Bio-Rad kits and an in-house immunoprecipitin assay (IPD), the Bordier kit had the highest sensitivity (97.7%), but the IPD tended to be more specific (71.2 and 84.7%, respectively; p=0.10).The use of recombinant, somatic and metabolic antigens in a single EIA improved the balance between sensitivity and specificity, resulting in an assay highly suitable for use in the diagnosis of chronic and allergic aspergillosis.
ISSN: 0095-1137

hal-01282328
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282328
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282328/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282328/file/Prospective%20evaluation%20of%20a%20new%20Aspergillus.pdf
DOI : 10.1128/JCM.03261-15

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
Knowing the slip amplitudes that large earthquakes produced in prehistorical times is one key to anticipate the magnitude of large forthcoming events. It is long known that the morphology is preserving remnants of paleoearthquake slips in the form of fault-offset landforms. However, the measured offsets that can be attributed to the most recent paleoearthquakes are generally few along a fault, so that they rarely allow recovering the slip distributions and largest slips of these earthquakes. We acquired ~1 m resolution airborne lidar data on a 30 km stretch of a fast-slipping strike-slip fault (eastern Hope Fault, New Zealand) located in a region of high alluvial dynamics where landforms are rapidly evolving. Data analysis reveals >200 offset landforms; only 30% allow a good to moderate quality offset measurement. From these good to moderate quality measures, we recover the slip-length distributions and largest slips of the four most recent large paleoearthquakes and find evidence of 4–6 prior events. The record suggests that large earthquake slip recurred in multiples of about 4 m along the 30 km stretch. Although they have larger uncertainties, the more numerous lower-quality offsets that we also measured reveal a similar earthquake slip record. This shows that, although offset landforms are partly degraded in dynamically active landscapes, they store valuable information on paleoearthquake slips. This information might be recovered provided that the morphology is analyzed at high resolution and " continuously " over a significant fault length. Remote lidar data are powerful to perform such analyses.
ISSN: 2169-9313

insu-01469219
https://hal-insu.archives-ouvertes.fr/insu-01469219
https://hal-insu.archives-ouvertes.fr/insu-01469219/document
https://hal-insu.archives-ouvertes.fr/insu-01469219/file/Manighetti_et_al-2015-Journalsur Geophysical_Research__Solid_Earth.pdf
DOI : 10.1002/2014JB011787

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
BACKGROUND: Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene have been identified in families with autosomal dominant Parkinson's disease (ADPD), the most common of which is the p.G2019S substitution that has been found at varying frequencies worldwide. Because of the size of the LRRK2 gene, few studies have analysed the entire gene in large series of ADPD families. METHODS: We performed extensive mutation analyses of all 51 coding exons of the LRRK2 gene in index cases from 226 Parkinson's disease families compatible with autosomal dominant inheritance, mostly from France (n = 182) and North Africa (n = 14). RESULTS: We found 79 sequence variants, 29 of which were novel. Eight potentially or proven pathogenic mutations were found in 22 probands (9.7%). There were four novel amino acid substitutions that are potentially pathogenic (p.S52F, p.N363S, p.I810V, p.R1325Q) and two novel variants, p.H1216R and p.T1410M, that are probably not causative. The common p.G2019S mutation was identified in 13 probands (5.8%) including six from North Africa (43%). The known heterozygous p.R1441H and p.I1371V mutations were found in two probands each, and the p.E334K variant was identified in one single patient. Most potentially or proven pathogenic mutations were located in the functional domains of the Lrrk2 protein. CONCLUSION: This study leads us to conclude that LRRK2 mutations are a common cause of autosomal dominant Parkinson's disease in Europe and North Africa.
ISSN: 0022-2593

inserm-00529272
http://www.hal.inserm.fr/inserm-00529272
DOI : 10.1136/jmg.2008.062612
PUBMED : 19357115

Éditeur(s) : HAL CCSD European Geosciences Union
Résumé : International audience
During the GWADASEIS cruise (Lesser Antilles volcanic arc, February-March 2009) a very high resolution (VHR) seismic-reflection survey was performed in order to constrain Late Quaternary to Present faulting. The profiles we obtained evidence frequent "ponding" of reworked sediments in the deepest areas, similar to the deposition of Mediterranean "homogenites". These bodies are acoustically transparent (few ms t.w.t. thick) and are often deposited on the hanging walls of dominantly normal faults, at the base of scarps. Their thickness appears sufficient to compensate (i.e. bury) co-seismic scarps between successive earthquakes, resulting in a flat and horizontal sea floor through time. In a selected area (offshore Montserrat and Nevis islands), piston coring (4 to 7 m long) was dedicated to a sedimentological analysis of the most recent of these particular layers. It corresponds to non-stratified homogenous calcareous silty sand (reworked calcareous plankton and minor volcanoclastics). This layer can be up to 2 m thick, and overlies finegrained hemipelagites. The upper centimeters of the latter represent the normal RedOx water/sediment interface. 210Pb and 137Cs activities lack in the massive sands, while a normal profile of unsupported 210Pb decrease is observed in the hemipelagite below, together with a 137Cs peak correspond- ing to the Atmospheric Nuclear Experiments (1962). The RedOx level was thus capped by a recent instantaneous major sedimentary event considered as post-1970 AD; candidate seismic events to explain this sedimentary deposits are either the 16 March 1985 earthquake or the 8 October 1974 one (Mw=6.3 and Mw=7.4, respectively). This leads to consider that the syntectonic sedimentation in this area is not continuous but results from accumulation of thick homogenites deposited after the earthquakes (as observed in the following weeks after Haiti January 2010 event, McHugh et al., 2011). The existence of such deposits suggests that, in the area of study, vertical throw likely results from cumulated effects of separated earthquakes rather than from aseismic creep. Examination of VHR profiles shows that all major co-seismic offsets are recorded in the fault growth sequence and that co-seismic offsets can be precisely estimated. By using a sedimentation rate deduced from 210Pb decrease curve (0.5 mm yr−1) and taking into account minor reworking events detected in cores, we show that the Redonda system may have been responsible for five >M6 events during the last 34 000 yr. The approach presented in this work differs from fault activity analyses using displaced sets of isochronous surfaces and postulating co-seismic offsets. Combining VHR seismic imagery and coring we can decipher co-seismic vs. slow continuous displacement, and thus actually estimate the amplitude and the time distribution of major co-seismic offsets.
ISSN: 1561-8633

insu-00844581
https://hal-insu.archives-ouvertes.fr/insu-00844581
https://hal-insu.archives-ouvertes.fr/insu-00844581/document
https://hal-insu.archives-ouvertes.fr/insu-00844581/file/nhess-12-1755-2012.pdf
DOI : 10.5194/nhess-12-1755-2012

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Retreatment with pegylated interferon (peg-IFN) and ribavirin (RBV) results in poor sustained virological response (SVR) rates in human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients. There are limited data regarding the use of telaprevir plus peg-IFN/RBV in this population. HIV type 1-infected patients who previously failed ≥12 weeks of peg-IFN/RBV for HCV genotype 1 coinfection were enrolled in a single-arm, phase 2 trial. Patients with cirrhosis and previous null response were excluded. Authorized antiretrovirals were tenofovir, emtricitabine, efavirenz, atazanavir, and raltegravir. All patients received peg-IFN alfa-2a (180 µg/week) plus RBV (1000-1200 mg/day) for 4 weeks, followed by telaprevir (750 mg or 1125 mg every 8 hours with efavirenz) plus peg-IFN/RBV for 12 weeks and peg-IFN/RBV for 32-56 weeks according to virological response at week 8. The primary endpoint was the SVR rate at 24 weeks after the end of treatment (SVR24). Sixty-nine patients started treatment; SVR24 was achieved in 55 (80% [95% confidence interval, 68%-88%). SVR24 was not influenced by baseline fibrosis stage, IL28B genotype, antiretroviral regimen, HCV subtype, CD4 cell count, previous response to HCV treatment, HCV RNA level, or HCV RNA decline at week 4. HCV treatment was discontinued for adverse events (AEs) in 20% of patients, including cutaneous (4%), psychiatric (4%), hematological (6%), and other AEs (6%). Peg-IFN or RBV dose reduction was required in 23% and 43% of patients, respectively. Seventy percent of patients required erythropoietin, blood transfusions, or RBV dose reduction for anemia. Two patients died during the study. No HIV breakthrough was observed. Despite a high discontinuation rate related to toxicity, a substantial proportion of treatment-experienced HIV-coinfected patients achieved SVR24 with a telaprevir-based regimen. Clinical Trials Registration. NCT01332955.
ISSN: 1058-4838

hal-01118447
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118447
PUBMED : 25139963
DOI : 10.1093/cid/ciu659

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND AND AIM: The impact of basal core promoter (BCP) and precore (PC) mutants of the hepatitis B virus (HBV) on liver disease severity remains controversial. The aim of the present study was to screen BCP and PC mutations in 252 HBV surface antigen (HBsAg) positive carriers in France and to assess relationships between these mutations and severe fibrosis. METHODS: Direct sequencing of the precore/core gene was used to detect A1762T/G1764A and G1757A mutations in the BCP and G1896A and G1899A mutations in the PC region. RESULTS: The prevalences of A1762T/G1764A, G1757A, G1896A, and G1899A mutations were 34.1%, 38.7%, 54.9%, and 29.3% (P < 0.001), respectively. The independent predictors of severe fibrosis (>/=F3 Metavir) were older age (P < 0.001), male gender (P = 0.012), elevated alanine aminotransferase (P < 0.001), and the double A1762T/G1764A mutant with no other mutations (P = 0.011). Interestingly, the association of the G1899A mutation with the double A1762T/G1764A mutant significantly counteracted the deleterious effect of the sole double A1762T/G1764A mutant (odds ratio [OR] = 0.28 vs. OR = 3.55, respectively, P = 0.028). CONCLUSIONS: Patients with the A1762T/G1764A mutation have a higher risk of severe fibrosis. The G1899A mutation is a protective factor against severe fibrosis that counteracted the deleterious effect of the A1762T/G1764A mutation. Finally, host phenotypic and HBV genotypic markers independently predict fibrosis severity.
Journal of gastroenterology and hepatology

hal-01477209
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477209
DOI : 10.1111/jgh.13338
PUBMED : 26992056

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Volumetrically minor microsyenites, alkali microgranite and related trachytic dykes intrude early Pliocene OIB-like alkali basaltic and basanitic flows of the Meseta del Lago Buenos Aires in Central Patagonia (47 degrees S-71 degrees 30'W), and occur together with scarce trachytic lava flows. Whole-rock K-Ar ages between 3.98 and 3.08 Ma indicate that the emplacement of these felsic rocks occurred more or less synchronously with that of the post-plateau basaltic sequence that they intrude, during a bimodal mafic-felsic magmatic episode devoid of intermediate compositions. Chemically, these rocks have A(1)-type granitoid affinities and are characterized by high silica and alkali contents (60-68 wt.% SiO2; 8.7-10.8 wt.% Na2O+K2O), major and trace elements patterns evidencing evolution by low-pressure fractional crystallization, and Sr and Nd isotopic signatures similar to those of coeval basalts ((Sr-87/Sr-86)o=0.70488-0.70571; (Nd-143/Nd-144)(o)=0.512603-0.512645). Nevertheless, some of them have the most radiogenic Sr values ever reported for a magmatic rock in the Meseta and even in the whole Neogene Patagonian Plateau Lavas province ((Sr-17/Sr-86)(o)= 0.70556-0.70571; (Nd-143/Nd-144)(o)=0.512603-0.512608). In addition, very high contents of strongly incompatible elements in the most evolved rocks, together with Sr isotopic ratios higher than those of coeval basalts, suggest the occurrence of open-system magmatic processes. Continuous fractional crystallization from a primitive basaltic source, similar to post-plateau coeval basalts, towards alkali granites combined with small rates of assimilation of host Jurassic tuffs (AFC) in a shallow magmatic reservoir, best explains the geochemical and petrographic features of the felsic rocks. Therefore, A(1)-type magmatic rocks can be generated by open-system crystallization of deep asthenospheric melts in back-are tectonic settings. In Central Patagonia, these similar to 3-4 Ma old alkaline intrusions occur aligned along a similar to N160-170 trending lineament, the Zeballos Fault Zone, stacking the morphotectonic front of one segment of the Patagonian Cordillera. Intrusion along this fault zone
ISSN: 0024-4937

hal-00412030
https://hal.archives-ouvertes.fr/hal-00412030
DOI : 10.1016/j.lithos.2007.07.002

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
The Lanzo peridotite massif is a fragment of oceanic lithosphere generated in an ocean-continent transition context and eclogitized during alpine collision. Despite the subduction history, the massif has preserved its sedimentary oceanic cover, suggesting that it may have preserved its oceanic structure. It is an exceptional case for studying the evolution of a fragment of the lithosphere from its oceanization to its subduction and then exhumation. We present a field and petrological study retracing the different serpentinization episodes and their impact on the massif structure. The Lanzo massif is composed of slightly serpentinized peridotites (<20% serpentinization) surrounded by an envelope of foliated serpentinites (100% serpentinization) bordered by oceanic metabasalts and metasedimentary rocks. The limit between peridotites and serpentinites defines the front of serpentinization. This limit is sharp: it is marked by the presence of massive serpentinites (80% serpentinization) and, locally, by dykes of metagabbros and mylonitic gabbros. The deformation of these gabbros is contemporaneous with the emplacement of the magma. The presence of early lizardite in the peridotites testifies that serpentinization began during the oceanization, which is confirmed by the presence of meta-ophicarbonates bordering the foliated serpentinite envelope. Two additional generations of serpentine occur in the ultramafic rocks. The first is a prograde antigorite that partially replaced the lizardite and the relict primary minerals of the peridotite during subduction, indicating that serpentinization is an active process at the ridge and in the subduction zone. Locally, this episode is followed by the deserpentinization of antigorite at peak P-T (estimated in eclogitized metagabbros at 2-2.5 GPa and 550-620 °C): it is marked by the crystallization of secondary olivine associated with chlorite and/or antigorite and of clinopyroxene, amphibole and chlorite assemblages. A second antigorite formed during exhumation partially to completely obliterating previous textures in the massive and foliated serpentinites. Serpentinites are an important component of the oceanic lithosphere generated in slow to ultraslow spreading settings, and in these settings, there is a serpentinization gradient with depth in the upper mantle. The seismic Moho limit could correspond to a serpentinization front affecting the mantle. This partially serpentinized zone constitutes a less competent level where, during subduction and exhumation, deformation and fluid circulation are localized. In this zone, the reaction kinetics are increased and the later steps of serpentinization obliterate the evidence of this progressive zone of serpentinization. In the Lanzo massif, this zone fully recrystallized into serpentinite during alpine subduction and collision. Thus, the serpentinite envelope represents the oceanic crust as defined by geophysicists, and the sharp front of serpentinization corresponds to an eclogitized seismic palaeo-Moho.
ISSN: 0263-4929

hal-00823051
https://hal.archives-ouvertes.fr/hal-00823051
DOI : 10.1111/jmg.12008

Éditeur(s) : HAL CCSD Copernicus Publications on behalf of the European Geosciences Union
Résumé : International audience
During the GWADASEIS cruise (Lesser Antilles volcanic arc, February–March 2009) a very high resolution (VHR) seismic-reflection survey was performed in order to constrain Late Quaternary to Present faulting. The profiles we obtained evidence frequent " ponding " of reworked sediments in the deepest areas, similar to the deposition of Mediterranean " homogenites ". These bodies are acoustically transparent (few ms t.w.t. thick) and are often deposited on the hanging walls of dominantly normal faults, at the base of scarps. Their thickness appears sufficient to compensate (i.e. bury) co-seismic scarps between successive earthquakes, resulting in a flat and horizontal sea floor through time. In a selected area (offshore Montserrat and Nevis islands), piston coring (4 to 7 m long) was dedicated to a sedimento-logical analysis of the most recent of these particular layers. It corresponds to non-stratified homogenous calcareous silty sand (reworked calcareous plankton and minor volcanoclas-tics). This layer can be up to 2 m thick, and overlies fine-grained hemipelagites. The upper centimeters of the latter represent the normal RedOx water/sediment interface. 210 Pb and 137 Cs activities lack in the massive sands, while a normal profile of unsupported 210 Pb decrease is observed in the hemipelagite below, together with a 137 Cs peak corresponding to the Atmospheric Nuclear Experiments (1962). The RedOx level was thus capped by a recent instantaneous major sedimentary event considered as post-1970 AD; candidate seismic events to explain this sedimentary deposits are either the 16 March 1985 earthquake or the 8 October 1974 one (M w = 6.3 and M w = 7.4, respectively). This leads to consider that the syntectonic sedimentation in this area is not continuous but results from accumulation of thick homogen-ites deposited after the earthquakes (as observed in the following weeks after Haiti January 2010 event, McHugh et al., 2011). The existence of such deposits suggests that, in the area of study, vertical throw likely results from cu-mulated effects of separated earthquakes rather than from aseismic creep. Examination of VHR profiles shows that all major co-seismic offsets are recorded in the fault growth sequence and that co-seismic offsets can be precisely estimated. By using a sedimentation rate deduced from 210 Pb decrease curve (0.5 mm yr −1) and taking into account minor reworking events detected in cores, we show that the Redonda system may have been responsible for five > M 6 events during the last 34 000 yr. The approach presented in this work differs from fault activity analyses using displaced sets of isochronous surfaces and postulating co-seismic offsets. Combining VHR seismic imagery and coring we can decipher co-seismic vs. slow continuous displacement, and thus actually estimate the amplitude and the time distribution of major co-seismic offsets.
Natural Hazards and Earth System Science

insu-01585969
https://hal-insu.archives-ouvertes.fr/insu-01585969
https://hal-insu.archives-ouvertes.fr/insu-01585969/document
https://hal-insu.archives-ouvertes.fr/insu-01585969/file/nhess-12-1755-2012-beck.pdf
DOI : 10.5194/nhess-12-1755-2012

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Demerara plateau, located offshore French Guiana and Suriname, is part of a passive transform continental margin particularly prone to develop slope instabilities, probably in relation to the presence of a free distal border along its steep continental slope. Slope failure occurred at different periods (Cretaceous to Neogene) and shows an overall retrogressive evolution through time. Upslope these failure headscarp, an enigmatic regional Mio-Pliocene unconformity has been discovered through the interpretation of new academic and industrial datasets. The aim of this work is to describe and understand the origin of this surface. Our analysis shows that this unconformity is made of a series of valleys that cross-cut sedimentary strata. Each one of these valleys has a short lateral extent and is closed along two perpendicular directions, which suggests that it could correspond to a highly meandering system, or to some sub-circular depressions. The infill of these features is equivalent to the regional stratigraphic strata found outside the structures, but in a subdued position. This seems to imply that the structures have originated by a local loss of sediments at their base or by sliding processes. Furthermore, these depressions intersect each other through time, while migrating progressively downslope.We discuss a series of hypotheses that try to explain the onset and evolution of these depressions forming the Mio-Pliocene unconformity (Canyons? Slope failures? Contourite moats? Hydrate pockmarks?). Having established that these structures are depressions formed by collapse, and have many similarities with structures recently described in the literature as pockmarks associated with gas hydrate dissolution, we favor this hypothesis.We propose that these hydrate pockmarks form with a mass failure that was triggered by fluid-overpressure development at the base of the hydrate stability zone.
ISSN: 0025-3227

hal-01365920
https://hal.archives-ouvertes.fr/hal-01365920
DOI : 10.1016/j.margeo.2015.04.001

Éditeur(s) : HAL CCSD Association Internationale de Climatologie
Résumé : 6 pages
International audience
This work presents an overview of spatio-temporal quality andspatial density of rainfall networks of Cameroon, Gabon, Congo, CAP and DRC, particularly in the recentperiod (1973-2014) through the GSOD international database. Faced with enormous gaps observed, theseresults will help to select metrological and analytical orientations in FORGREENE project (Tropical forestsgreeness and cloudiness in Central Africa: present conditions and future evolution). A comparison with rainfallsatellite estimates (RFE type) also indicates their great potential, provided they are based on in situ validations.
Ce travail fait un état des lieux de la qualité temporelle et de la densité spatiale des sériespluviométriques du Cameroun, Gabon, Congo, RCA et RDC, en particulier sur la période récente (1973-2014)grâce à la base de données internationale GSOD. Face aux énormes lacunes observées, ces résultats vontpermettre d’orienter les choix métrologiques et analytiques in situ du programme FORGREENE (Tropicalforests greeness and cloudiness in Central Africa: present conditions and future evolution). Une comparaisonavec des estimations satellitaires (de type RFE) indique aussi leur potentiel intéressant, à condition qu’elless’appuient sur des validations in situ.
Climat et pollution de l'air
Besançon, France

hal-01360178
https://hal.archives-ouvertes.fr/hal-01360178

Éditeur(s) : HAL CCSD Wiley Open Access
Résumé : Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project - and avert - future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups - including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems - ). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.
ISSN: 2045-7758

hal-01204216
https://hal.archives-ouvertes.fr/hal-01204216
DOI : 10.1002/ece3.1303
PRODINRA : 280886