Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Located in central Europe at the junction of the Southern Alps and the Dinarides, the ≈ 100 km long Idrija fault, striking N310 and dipping ≈ 80°NE is often considered as the potential source of the historical 1511 earthquake (estimated macroseismic magnitude: Mm 6.8). Using 1/25,000 to 1/5000 topographical maps, satellite images (SPOT5), 12.5 m illuminated DEM and airborne LiDAR data-derived 1-m-DEM, we examined in detail the Idrija fault trace along a 20-km-long swath in the central portion of the fault. Combining topographic and remote sensing data allows characterizing the recent activity along the Idrija fault and estimating its cumulative displacement along strike.Between Tolmin and Godovič, the fault trace is mostly linear but appears divided into three disconnected segments of 11–20-km-long. Morphological evidences such as offset streams and ridges and major drainage abandonments suggest ongoing movement. At three sites, field observations and LiDAR-DEM analysis allow measuring cumulative dextral offsets comprised between 35 and 65 m. We found two larger offsets of ≈ 140 m and ≈ 360 m at the southeasternmost site. The vertical component is significant and revealed by a rake ranging from 0 to 33°. The derived N303–N310 striking slip-vector is in agreement with the motion along this fault as suggested by the geodesy. Assuming that the smallest measured offsets have been recorded after the last glacial maximum (LGM, about 20 ka ago), the minimum slip-rate for the Idrija fault is about 1.5 mm/yr over this period of time.
ISSN: 0040-1951

hal-01115724
https://hal.archives-ouvertes.fr/hal-01115724
DOI : 10.1016/j.tecto.2014.04.043

Éditeur(s) : HAL CCSD
Résumé : International audience
The published literature related to distributed parameter systems theoryis quite large, and it is not feasible in a single book to give a detailedreview on the wide historical development of all of it. Our choice of whatto cover was motivated by the following consideration. Since distributedparameter systems evolve in time and space, the research investigationson their analysis and control focus on considering the whole system domainfor any study. We feel strongly that within this research field, animportant consideration was missing; that of considering that the systemmay give raise to prescribed subdomains (regions) where one has toachieve an objective. This is the case of so many applications rangingfrom engineering to life sciences. For that reason, covering classical prerequisitein analysis and control areas, we have devoted the book to theextension of the classical distributed parameter results to regional ones.Students of mathematics do not come into contacts with distributedparameter systems during their classes. They are introduced to themwhen they start research and often they are influenced by the knowledgeand the advice of experimented scientists. This was our case at the verybeginning of these research investigations in the mid 70’s. We would liketo express our special thanks to many of them and mainly late ProfessorAnthony J. Pritchard (University of Warwick, GB) and late Professor J.L. Lions (College de France) who were so encouraging in front of our determinationin driving an academic carrier. We also express our thanksto our co-workers and research students. We wish to acknowledge thefeedback from all those who took courses based on various parts of thisbook.This book may be used by graduate students in mathematics, engineering,physics, and even by students from other fields such as life orenvironmental sciences. This book may also be used as an informationvi Avant-propossource for researchers and education professionals. We assume that thereaders already know the basic concepts of analysis and control of distributedparameter systems.
https://hal.archives-ouvertes.fr/hal-01297261

ISBN : 978-2-35412-140-2
hal-01297261
https://hal.archives-ouvertes.fr/hal-01297261

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Benthic cyanobacterial mats (BCMs) are impacting coral reefs worldwide. However, the factors and mechanisms driving their proliferation are unclear. We conducted a multi-year survey around the Caribbean island of Curaçao, which revealed highest BCM abundance on sheltered reefs close to urbanised areas. Reefs with high BCM abundance were also characterised by high benthic cover of macroalgae and low cover of corals. Nutrient concentrations in the water-column were consistently low, but markedly increased just above substrata (both sandy and hard) covered with BCMs. This was true for sites with both high and low BCM coverage, suggesting that BCM growth is stimulated by a localised, sub-strate-linked release of nutrients from the microbial degradation of organic matter. This hypothesis was supported by a higher organic content in sediments on reefs with high BCM coverage, and by an in situ experiment which showed that BCMs grew within days on sediments enriched with organic matter (Spirulina). We propose that nutrient runoff from urban-ised areas stimulates phototrophic blooms and enhances organic matter concentrations on the reef. This organic matter is transported by currents and settles on the seabed at sites with low hydrodynamics. Subsequently, nutrients released from the organic matter degradation fuel the growth of BCMs. Improved management of nutrients generated on land should lower organic loading of sediments and other benthos (e.g. turf and macroalgae) to reduce BCM proliferation on coral reefs.
ISSN: 1932-6203

hal-01159626
https://hal-univ-perp.archives-ouvertes.fr/hal-01159626
https://hal-univ-perp.archives-ouvertes.fr/hal-01159626/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01159626/file/journal.pone.0125445.pdf
DOI : 10.1371/journal.pone.0125445

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : Rock foundations of the Kephren and Kheops pyramids are examined in comparison with other Fourth Dynasty monuments: the Sphinx, Queen Kentkawes' monument and the Abu Rawash monument. This study is based on geological and topographical observations, photomontages and field measurements. The results, which are correlated with those of former studies, demonstrate the existence of natural hills used as substrata in the construction of the two great pyramids. The minimum volume of these hills can be estimated at 12% and 23% respectively of the volumes of the Kephren and Kheops pyramids. The use of worked rock hills appears to be a construction method under the Fourth Dynasty.
EISSN: 1777-5817

hal-00512644
https://hal.archives-ouvertes.fr/hal-00512644

Éditeur(s) : HAL CCSD International Phycological Society
Résumé : International audience
We studied a group of monoraphid diatom species (Bacillariophyceae, Achnanthidiaceae) found in the marine coastal environment of tropical islands of the Caribbean Sea, western Atlantic Ocean, Indian Ocean, South Pacific Ocean, the Adriatic Sea and the Black Sea. Based on light and electron microscope examination, Madinithidium was formally described as a genus new to science with the generitype defined as Madinithidium undulatum. The characteristic features of the valve structure are a strongly developed sternum and raphe sternum, transapical striae formed by a single areola (macroareolae) positioned in small depressions, elevated virgae and coaxial internal central raphe endings. Furthermore, the striae of both raphe and sternum valves are closed by finely perforated hymenes. Madinithidium and Achnanthidium species are difficult to identify correctly with light microscopy since their valves are small and finely structured. Four species recently described from the western Indian Ocean and assigned to Achnanthidium sensu lato – Achnanthidium capitatum, A. flexuistriatum, A. pseudodelicatissimum and A. scalariforme – possessed morphological features permitting their placement into Madinithidium gen. nov. The above-mentioned species were formally transferred to the new genus.
ISSN: 2330-2968

hal-01333391
https://hal-univ-perp.archives-ouvertes.fr/hal-01333391
DOI : 10.2216/14-21R2

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Plio-Pleistocene diatomitic sequences in the Shamb paleo-lake (South Armenia, Lesser Caucasus) offer a rare opportunity to give new insights on the paleo-climate of Western Asia. We present an integrated palynological, 40Ar/39Ar geochronologic and magnetostratigraphic study for the most complete section in the sedimentary deposits of the Shamb paleo-lake. 40Ar/39Ar dating of two volcaniclastic layers provided ages of 1.24 ± 0.03 and 1.16 ± 0.02 Ma (2. Magnetostratigraphic data show that the entire Shamb section is of reversed polarity which, combined with 40Ar/39Ar dating, suggests that the entire section correlates with part of the Matuyama period (1.785-1.070 Ma). Pollen assemblages and macroremains diversity clearly show an alternation of glacial and interglacial phases. Age calibrations and accumulation rate extrapolation allow a direct correlation of climate changes with the global isotopic curve, and show that the Shamb section probably ranges from approximately 1.300 to 1.080 Ma (marine isotopic stages 40 to 31). The vegetation of the Lesser Caucasus developed in a mosaic pattern in a Pleistocene continental, mostly arid climate, comparable to the present-day climate. The observed vegetation changes record a dominant climate response to the obliquity orbital parameter, but the influence of precession could not be established from the Shamb data. Pollen and macroflora both indicate that glacial periods were cold and dry and that interglacials were warm with local humidity. The early Pleistocene climatic model for Western Asia is thus similar to the climatic model for the Mediterranean area.
ISSN: 0012-821X

hal-00470353
https://hal.archives-ouvertes.fr/hal-00470353
DOI : 10.1016/j.epsl.2010.01.007

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : In Vietnam, the Triassic Indosinian collision affected coevally the Truong Son belt and the Kontum Massif,which were not independent tectonic units, but parts of the same Gondwana-derived Indochina continental block. This thermotectonic event took place synchronously throughout Vietnam, during the Lower Triassic 250-240-Ma time interval, as demonstrated by numerous geochronological data, combining Ar-Ar and U-Pb dating methods. Structural and kinematic investigations, in the Indosinian metamorphic rocks, reveal that the collisional process resulted from a consistent northwest-striking convergence of Indochina with respect to the adjacent blocks. It is suggested that this motion was taken up by a pair of opposite subduction zones: to the north, beneath South China, and to the west, beneath western Indochina, along the Song Ma and Po Ko sutures, respectively. Tectonic markers, calc-alkaline subduction-related volcanism and granitic intrusions and the generation of high-pressure rocks that have been recently discovered support this geodynamic setting, at least along Po Ko. Along the northwest-trending Song Ma zone, the obliquity of the convergence during subduction and subsequent collision resulted in the development, within the Truong Son Belt, of a set of subparallel dextral mylonitic shear zones, under amphibolite-facies metamorphism. The intermediate segments remained weakly metamorphic or even almost devoid of metamorphism. Along Po Ko, the convergence was near-orthogonal, with a left-lateral strike-slip component; the ongoing continental subduction resulted in the reworking of the Kontum granulitic basement and the development of Indosinian HP granulitic conditions; the subsequent extension-related exhumation operated approximately in the same northwestwards direction. This Indosinian evolution, applied on a continental crust that had been probably affected, as in South China, by a Caledonian-related event, as judged by the general unconformity of the Lower Devonian sediments, the widespread occurrence of magmatic crystallisation ages of ca 450 Ma (Ordovician-Silurian), and by the approximately similar age of the primary granulitic episode in the Kontum Massif. The similarities of the Devonian facies over central, northern Vietnam and South China imply a land connection, possibly as a consequence of a Caledonian collision along Song Ma, but this does not preclude a further oceanic opening and a closure during the Indosinian.
ISSN: 1631-0713

hal-00411591
https://hal.archives-ouvertes.fr/hal-00411591
DOI : 10.1016/j.crte.2007.10.005

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : The analysis of fine-scale spatial genetic structure (FSGS) within populations can provide insights into eco-evolutionary processes. Restricted dispersal and locally occurring genetic drift are the primary causes for FSGS at equilibrium, as described in the isolation by distance (IBD) model. Beyond IBD expectations, spatial, environmental or historical factors can affect FSGS. We examined FSGS in seven African and Neotropical populations of the late-successional rain forest tree Symphonia globulifera L. f. (Clusiaceae) to discriminate the influence of drift-dispersal vs. landscape/ecological features and historical processes on FSGS. We used spatial principal component analysis and Bayesian clustering to assess spatial genetic heterogeneity at SSRs and examined its association with plastid DNA and habitat features. African populations (from Cameroon and São Tomé) displayed a stronger FSGS than Neotropical populations at both marker types (mean Sp = 0.025 vs. Sp = 0.008 at SSRs) and had a stronger spatial genetic heterogeneity. All three African populations occurred in pronounced altitudinal gradients, possibly restricting animal-mediated seed dispersal. Cyto-nuclear disequilibria in Cameroonian populations also suggested a legacy of biogeographic history to explain these genetic patterns. Conversely, Neotropical populations exhibited a weaker FSGS, which may reflect more efficient wide-ranging seed dispersal by Neotropical bats and other dispersers. The population from French Guiana displayed an association of plastid haplotypes with two morphotypes characterized by differential habitat preferences. Our results highlight the importance of the microenvironment for eco-evolutionary processes within persistent tropical tree populations.
ISSN: 1932-6203

hal-01608324
https://hal.archives-ouvertes.fr/hal-01608324
DOI : 10.1371/journal.pone.0182515
PRODINRA : 403154
PUBMED : 28771629

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Objective. — The aim of this study was to validate the French translation of the category-rating-10 used for assessing perceived exertion (RPE) when monitoring training loads. Methods. — Fifty athletes from individual (Taekwondo) and team sports (soccer) volunteered. Two forward translations, a reconciled version, and then a back-translation were completed to validate the final French version. French Session-RPE, heart rate, and duration were recorded for 622 training sessions.Results. —The comparability of language and similarity of interpretability using a Likert scale were 2 and 1, respectively. A high Cronbach’s coefficient ( = 0.77) was found. The intraclass correlation coefficient of session-RPE was 0.77. High correlations were determined between the session-RPE and HR-based methods during training sessions. The effect size was 0.97.Conclusion. — When monitoring training load, the French version of category-rating-10 exhibits similar reliability, validity, and sensitivity to change as the English version.
Objectif. — L’objet de cette étude était de valider la traduction franc¸aise de l’échelle de la Note de Catégorie-10 utilisée dans l’évaluation de la perception de l’effort pour contrôler la charge d’entraînement.Méthode. —Cinquante athlètes de sport individuel (taekwondo) et d’équipe (football) ont volontairement participé à l’étude. Deux traductions en mode direct, une version réconciliée, puis une traduction indirecte ont été effectuées pour évaluer la version franc¸aise finale. Lafréquence cardiaque, la durée et la charge d’entraînement quantifiée par la version franc¸aise ont été enregistrées durant 622 séances d’entraînement.Résultats. — La comparaison et la similarité de l’interprétation en utilisant l’échelle de Likert étaient de 2 et 1, respectivement. Un coefficient élevé de -Cronbach a été calculé ( = 0,77). Le coefficient de corrélation intraclasse de la RPE-de-séance était de 0,77. Des corrélations élevées ont été observées entre la RPE-séance et les différentes méthodes de contrôle de la charge d’entraînement basées sur la FC (les méthodes de Banister et d’Edwards). L’effet de taille de l’échantillon était de 0,97.Conclusion. —Dans le cadre du contrôle de la charge d’entraînement, la version franc¸aise de l’échelle de la Note de Catégorie-10 présente une similarité de fiabilité, validé et sensibilité aux changements avec la version anglaise.
ISSN: 0765-1597

hal-01163458
https://hal.univ-antilles.fr/hal-01163458
DOI : 10.1016/j.scispo.2012.07.008

Éditeur(s) : HAL CCSD Cambridge University Press (CUP)
Résumé : International audience
Andros is a key island for understanding both the timing of high-pressure–low-temperature(HP-LT) metamorphism and the dynamics of crustal-scale detachment systems exhuming high-gradeunits in the Cyclades (Greece). Using phengite 40Ar–39Ar geochronology coupled with thermobarometry,as well as data from literature, we constrain the pressure–temperature–time (P-T-t) paths of theMakrotantalon and Attic–Cycladic Blueschist units on Andros. Peak conditions of the HP-LT episodein the Makrotantalon unit are 550 °C and 18.5 kbar, dated at 116 Ma. We correlate this episode withEarly Cretaceous blueschist facies metamorphism recognized in the Pelagonian zone of continentalGreece. This is a new argument favouring a Pelagonian origin for the Makrotantalon unit. In the Attic–Cycladic Blueschist unit, the P-T-t path is characterized by: (1) exhumation after peak conditions inHP-LT conditions between 55 and 35 Ma; (2) isobaric heating at 7 kbar until 30 Ma; and (3) isothermaldecompression until 21 Ma. This thermal evolution and timing are similar to those of the neighbouringTinos Island, emphasizing major thermal re-equilibration at the transition between stable and retreatingsubduction. Modifications of the crustal thermal state played a major role in the evolution of the NorthCycladic Detachment System, below which Andros HP-LT units were exhumed.
ISSN: 0016-7568

insu-01114909
https://hal-insu.archives-ouvertes.fr/insu-01114909
DOI : 10.1017/S0016756814000661

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : The area of forest plantations is increasing worldwide helping to meet timber demand and protect natural forests. However, with global change, monospecific plantations are increasingly vulnerable to abiotic and biotic disturbances. As an adaption measure we need to move to plantations that are more diverse in genotypes, species, and structure, with a design underpinned by science. TreeDivNet, a global network of tree diversity experiments, responds to this need by assessing the advantages and disadvantages of mixed species plantations. The network currently consists of 18 experiments, distributed over 36 sites and five ecoregions. With plantations 1-15 years old, TreeDivNet can already provide relevant data for forest policy and management. In this paper, we highlight some early results on the carbon sequestration and pest resistance potential of more diverse plantations. Finally, suggestions are made for new, innovative experiments in understudied regions to complement the existing network.
ISSN: 0044-7447

hal-01204232
https://hal.archives-ouvertes.fr/hal-01204232
DOI : 10.1007/s13280-015-0685-1
PRODINRA : 324368
PUBMED : 26264716

Éditeur(s) : HAL CCSD IOS Press
Résumé : International audience
This study tested the hypothesis that trained sickle cell trait (SCT) carriers are not subjected to greater risk of rhabdomyolysis or renal failure in response to moderate submaximal exercise than subjects with normal hemoglobin (CONT). Blood markers in 11 trained SCT carriers and 12 control counterparts were measured before and after 40 min of exercise at 55% of peak power output (Ppeak) conducted in thermoneutral environment. Body weights decreased with exercise in the same proportion in the two groups (from 65.1 ± 7.0 kg to 64.1 ± 7.0 kg and from 70.2 ± 6.6 to 68.6 ± 6.6 kg at the end of exercise in SCT and CONT, respectively). Heart rate and rectal temperature increased in the two groups in response to exercise, but the groups remained closely matched. Serum urea, CRP, CK and LDH were similar in the two groups and remained unchanged in response to exercise. Creatinine, Na + , K + , Cl − and myoglobin concentrations increased above baseline in response to exercise, with changes of the same magnitude in the two groups. In summary, the results of the present study suggest that moderate submaximal exercise is not unsafe from a biochemical point of view for sportsmen carrying SCT.
ISSN: 1386-0291

hal-01163943
https://hal.univ-antilles.fr/hal-01163943
DOI : 10.3233/CH-2011-1524

Éditeur(s) : HAL CCSD Wiley/Blackwell
Résumé : 4 pages
International audience
This article documents the addition of 268 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Alburnoides bipunctatus, Chamaerops humilis, Chlidonias hybrida, Cyperus papyrus, Fusarium graminearum, Loxigilla barbadensis, Macrobrachium rosenbergii, Odontesthes bonariensis, Pelteobagrus vachelli, Posidonia oceanica, Potamotrygon motoro, Rhamdia quelen, Sarotherodon melanotheron heudelotii, Sibiraea angustata, Takifugu rubripes, Tarentola mauritanica, Trimmatostroma sp. and Wallago attu. These loci were cross-tested on the following species: Alburnoides fasciatus, Alburnoides kubanicus, Alburnoides maculatus, Alburnoides ohridanus, Alburnoides prespensis, Alburnoides rossicus, Alburnoides strymonicus, Alburnoides thessalicus, Alburnoides tzanevi, Carassius carassius, Fusarium asiaticum, Leucaspius delineatus, Loxigilla noctis dominica, Pelecus cultratus, Phoenix canariensis, Potamotrygon falkneri, Trachycarpus fortune and Vimba vimba.
ISSN: 1755-098X

hal-00823716
https://hal.archives-ouvertes.fr/hal-00823716
DOI : 10.1111/1755-0998.12095
PUBMED : 23521844

Éditeur(s) : HAL CCSD springer Link
Résumé : International audience
Experimental Astronomy

hal-01094521
https://hal.archives-ouvertes.fr/hal-01094521
BIBCODE : 2014ExA...tmp...41R
DOI : 10.1007/s10686-014-9383-4
ARXIV : 1310.0696

Éditeur(s) : HAL CCSD Wiley
Résumé :  
The symbiotic interactions between Frankia strains and their associated plants from the Casuarinaceae under controlled conditions are well documented but little is known about these interactions under natural conditions. We explored the symbiotic interactions between eight genotypically characterized Frankia strains and five Casuarinaceae species in long-term field trials. Characterization of strains was performed using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for the nifD-nifK intergenic transcribed spacer (ITS) and 16S-23S ITS. Assessments of the symbiotic interactions were based on nodulation patterns using nodule dry weight and viability, and on actual N-2 fixation using the delta N-15 method. The PCR-RFLP patterns showed that the analyzed strains belonged to the same genotypic group (CeD group), regardless of the host species and environment of origin. The nodule viability index is introduced as a new tool to measure the viability of perennial nodules and to predict their effectiveness. The host Casuarinaceae species was a key factor influencing both the actual N-2-fixing activity of the associated Frankia strain and the viability of nodules within a location. This is the first study providing information on the symbiotic interactions between genotypically characterized Frankia strains and actinorhizal plants under natural conditions. The results revealed a way to improve a long-term management of the Casuarinaceae symbiosis.
ISSN: 0031-9317

hal-01032134
https://hal.archives-ouvertes.fr/hal-01032134
DOI : 10.1111/j.1399-3054.2007.00856.x

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
ISSN: 0022-1899

hal-01123839
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01123839
DOI : 10.1093/infdis/jiv129
PUBMED : 25737560

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The chronostratigraphy of the lower Miocene deposits of northwestern Sardinia is refined in the Castelsardo Basin. The combination of new 40Ar/39Ar isotopic datings, 19 micropalaeontological datings (calcareous nannofossils, planktonic and large benthic foraminifers) and 16 palaeomagnetic polarity measurements led to a new chronostratigraphic framework. The continental deposits of the first megasequence (Valledoria and Casteldoria members) are possibly Aquitanian. The overlying marine sediments are early Burdigalian (Vaginella depressa Molasse). The marine transgression can be dated to around 19.7 Ma. Marine conditions ceased 18.83 ± 0.13 Ma, the age of the index aerial τ2 ignimbrite. The continental part of the second megasequence (“Lacustre” unit) is early–middle Burdigalian, between 18.8 and 18 Ma. The overlying marine part (Campulandu and Sedini members) is middle–late Burdigalian. The second marine transgression began in the earliest–late Burdigalian, during the Chron C5Dr reversal, at the time of the eustatic Bur 4 event. The Castelsardo basin went through two main extensional tectonic episodes. The first one occurred as the Valledoria Member was deposited and possibly dates back to the Aquitanian. The second one occurred as the uppermost part of the Vaginella depressa Molasse was deposited during the early Burdigalian. The second extensional episode is related to a rapid rotation of Sardinia. Palaeomagnetic results confirm that Corsica and Sardinia acted as a single block which suffered a 28 ± 17° ccw rotation after 19.2 Ma. The Castelsardo basin is held to be an Aquitanian–early Burdigalian intra-arc rift basin that later evolved in a thermally controlled subsident margin of the Ligurian-Provençal Basin during the middle–late Burdigalian.
ISSN: 0031-0182

hal-00498288
https://hal.archives-ouvertes.fr/hal-00498288
DOI : 10.1016/j.palaeo.2010.06.007

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Growth hormone (GH) may stimulate water loss during exercise by activating sweating. This study investigated GH secretion and water loss during sequential cycling and running, taking postural changes into account. The two exercise segments had similar durations and were performed at the same relative intensity to determine their respective contributions to water loss and the plasma volume variation noted in such trials. Eight elite triathletes first performed an incremental cycle test to assess maximal oxygen consumption. Then, the triathletes performed one of two trials in randomized order: constant submaximal cycling followed by treadmill running (C 1 –R 2) or an inversed succession of running followed by cycling (R 1 –C 2). Each segment of both trials was performed for 20 minutes at ,75% of maximal oxygen consumption. The second trial, reversing the segment order of the first trial, took place two weeks later. During cycling, the triathletes used their own bicycles equipped with a profiled handlebar. Blood sampling (for GH concentrations, plasma viscosity and plasma volume variation) was conducted at rest and after each segment while water loss was estimated from the post-and pre-measures. GH increases were significantly lower in R 2 than C 2 (72.2650.1 vs. 164.06157 ng.ml 21 .min 21 , respectively; P,0.05). Water loss was significantly lower after C 1 –R 2 than R 1 –C 2 (11056163 and 12356153 ml, respectively; P,0.05). Plasma volume variation was significantly negative in C 1 and R 1 (26.1562.0 and 23.1665.0%, respectively; P,0.05), not significant in C 2 , and significantly positive for seven subjects in R 2 (4.0563.1%). We concluded that the lower GH increases in R 2 may have contributed to the smaller reduction in plasma volume by reducing sweating. Moreover, this lower GH response could be explained by the postural change during the transition from cycling to running. We recommend to pay particular attention to their hydration status during R 1 which could limit a potential dehydration during C 2 .
ISSN: 1932-6203

hal-01158212
https://hal.univ-antilles.fr/hal-01158212
DOI : 10.1371/journal.pone.0096145

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
The implication of oxidative stress as primary mechanism inducing doxorubicin (DOX) cardiotoxicity is still questionable as many in vitro studies implied supra-clinical drug doses or unreliable methodologies for reactive oxygen species (ROS) detection. The aim of this study was to clarify whether oxidative stress is involved in compliance with the conditions of clinical use of DOX, and using reliable tools for ROS detection. We examined the cytotoxic mechanisms of 2 μM DOX 1 day after the beginning of the treatment in differentiated H9c2 rat embryonic cardiac cells. Cells were exposed for 2 or 24 h with DOX to mimic a single chronic dosage or to favor accumulation, respectively. We found that apoptosis was prevalent in cells exposed for a short period with DOX: cells showed typical hallmarks as loss of anchorage ability, mitochondrial hyperpolarization followed by the collapse of mitochondrial activity, and nuclear condensation. Increasing the exposure period favored a shift to necrosis as the cells preferentially exhibited early DNA impairment and nuclear swelling. In either case, measuring the fluorescence lifetime of 1-pyrenebutyric acid or the intensities of dihydroethidium or amplex red showed a consistent pattern in ROS production which was a slight increased level far from representative of an oxidative stress. Moreover, pre-treatment with dexrazoxane provided a cytoprotective effect although it failed to detoxify ROS. Our data support that oxidative stress is unlikely to be the primary mechanism of DOX cardiac toxicity in vitro.
ISSN: 0300-8177

hal-01285736
https://hal-univ-perp.archives-ouvertes.fr/hal-01285736
DOI : 10.1007/s11010-016-2653-x

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
Understanding the distribution of genetic diversity in the light of past demographic events linked with climatic shifts will help to forecast evolutionary trajectories of ecosystems within the current context of climate change. In this study, mitochondrial sequences and microsatellite loci were analysed using traditional population genetic approaches together with Bayesian dating and the more recent approximate Bayesian computation scenario testing. The genetic structure and demographic history of a commercial fish, the black scorpionfish, Scorpaena porcus, was investigated throughout the Mediterranean and Black Seas. The results suggest that the species recently underwent population expansions, in both seas, likely concomitant with the warming period following the Last Glacial Maximum, 20 000 years ago. A weak contemporaneous genetic differentiation was identified between the Black Sea and the Mediterranean Sea. However, the genetic diversity was similar for populations of the two seas, suggesting a high number of colonizers entered the Black Sea during the interglacial period and/or the presence of a refugial population in the Black Sea during the glacial period. Finally, within seas, an east/west genetic differentiation in the Adriatic seems to prevail, whereas the Black Sea does not show any structured spatial genetic pattern of its population. Overall, these results suggest that the Black Sea is not that isolated from the Mediterranean, and both seas revealed similar evolutionary patterns related to climate change and changes in sea level.
ISSN: 1471-8278

hal-01330323
https://hal-univ-perp.archives-ouvertes.fr/hal-01330323
DOI : 10.1111/mec.13616