Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BACKGROUND: Recent studies suggest that a Mediterranean dietary pattern during pregnancy may influence pregnancy outcomes. The aim of this study was to evaluate the effect of adherence to a Mediterranean diet (MD) during pregnancy on fetal growth restriction (FGR) and preterm delivery (PTD) in a French Caribbean island where the population is largely of African descent and presents dietary patterns similar to MD. METHODS: Using data from the TIMOUN Mother-Child Cohort Study conducted in Guadeloupe (French West Indies) between 2004 and 2007, we analysed data for 728 pregnant women who delivered liveborn singletons without any major congenital malformations. Degree of adherence to MD during pregnancy was evaluated with a semi-quantitative food frequency questionnaire based on nine dietary criteria. Multiple logistic regression models were used to analyse birth outcomes while taking potential confounders into account. RESULTS: Overall there was no association between MD adherence during pregnancy and the risk of PTD or FGR. However, pre-pregnancy body mass index was a strong effect modifier, and MD adherence was associated with a decreased risk of PTD specifically in overweight and obese women (adjusted odds ratio 0.7, 95% confidence interval 0.6, 0.9) (P heterogeneity <0.01). CONCLUSIONS: These results suggest that Caribbean diet during pregnancy may carry some benefits of MD and may contribute to reduce the risk of PTD in overweight and obese pregnant women.
ISSN: 0269-5022

hal-00988172
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00988172
DOI : 10.1111/ppe.12113
PUBMED : 24754337

Éditeur(s) : HAL CCSD Geological Society of America
Résumé : International audience
We present the first recorded global positioning system (GPS) data from Myanmar measured at the northern tip of the Sagaing fault. This area is in a very complex geodynamic context, where rigid and semirigid plates interact. The 12 GPS sites measured in 2005 and 2008 in northern Myanmar show that the slip rate is 18 mm/yr and is localized along a single active narrow fault trace (<20 km wide). The same rate was previously demonstrated and remeasured, 500 km southward, in central Myanmar. Despite the geodynamic regional complexity induced by interaction between the Sunda and India plates, the Burma microplate, and the highly deformable eastern Himalayan syntaxis, the slip rate remains surprisingly constant along this fault. However, the modeled locking depth varies from 20 km in central Myanmar to 5 km in the north.
ISSN: 0091-7613

hal-00673712
https://hal.archives-ouvertes.fr/hal-00673712
DOI : 10.1130/G30872.1

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
This work is concerned with the study of the tribologic properties of room temperature fluorinated graphite heat-treated under fluorine atmosphere. The fluorinated compounds all present good intrinsic friction properties (friction coefficient in the range 0.05–0.09). The tribologic performances are optimized if the materials present remaining graphitic domains (influenced by the presence of intercalated fluorinated species) whereas the perfluorinated compounds, where the fluorocarbon layers are corrugated (armchair configuration of the saturated carbon rings) present higher friction coefficients. Raman analyses reveal that the friction process induces severe changes in the materials structure especially the partial re-building of graphitic domains in the case of perfluorinated compounds which explains the improvement of μ during the friction tests for these last materials.
ISSN: 1023-8883

hal-00767637
https://hal.archives-ouvertes.fr/hal-00767637
https://hal.archives-ouvertes.fr/hal-00767637/document
https://hal.archives-ouvertes.fr/hal-00767637/file/Delbe_6329.pdf
DOI : 10.1007/s11249-009-9487-6

Éditeur(s) : HAL CCSD
Actes du 38ème Congres Groupe Français des pesticides
Brest, France

hal-00672031
https://hal.archives-ouvertes.fr/hal-00672031

Éditeur(s) : HAL CCSD
Résumé : International audience
After the 2009 Morakot typhoon, which triggered numerous large landslides in Taiwan, Mouyen et al. (2013)showed for the first time the potential of time-lapse gravity survey to infer the mass of sediments transferringby landsliding or through rivers. By providing an integrated measurement of masses, gravimetry might thus becomplementary to common methods used to assess the sediments discharge of rivers. But the masses of rocksdisplaced by Morakot were exceptionally large as a result of the record-breaking rainfalls brought by this typhoonand one might wonder to what extent time-lapse gravimetry could record such sediment transfers. In order tobetter assess the capabilities of this method, we set a time-lapse gravity network dedicated to the monitoring ofsuch sediments transfers in Paolai village (south-central Taiwan). Paolai is located near the large Laonong riverwhere temporary alluvial deposits of sediments exist and face steep mountain slopes likely to experience landslides.Both features are considered as potential source of mass transfers, and in turn of temporal gravity changes. Thefirst base gravity measurements were done in November 2015, using absolute and relative gravimeters, and will berepeated every year, before and after the typhoon season. In the same time, we also use a terrestrial lidar to scan thegeometry of both the river and the mountain slopes, hence providing a detailed topographical survey of the studiedarea. Adding Lidar measurements is an efficient strategy to solve for the non-uniqueness of gravity solutions.Meanwhile, we use the Eros morphodynamic model, that combine landsliding and flooding models, to investigatevarious scenarios of landsliding and subsequent sediment transport and compute the gravity changes on a virtualnetwork of gravimeters. This gives us insights on the expected order of magnitudes for these surface sedimenttransfers, which are useful to unravel the induced gravity signal from others sources such as local hydrology orvertical ground displacements. The modeling results also enable us to set network location that are best defined todetect mass changes associated with sediment transfer. The main objective of this study is to test whether timelapsegravity brings a new and reliable information compared to present methods monitoring sediments transfersand landscape evolution.
European Geosciences Union General Assembly 2016
Vienne, Austria

insu-01308554
https://hal-insu.archives-ouvertes.fr/insu-01308554

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Diploid budding yeast undergoes rapid mitosis when it ferments glucose, and in the presence of a non-fermentable carbon source and the absence of a nitrogen source it triggers sporulation. Rich medium with acetate is a commonly used pre-sporulation medium, but our understanding of the molecular events underlying the acetate-driven transition from mitosis to meiosis is still incomplete. We identified 263 proteins for which mRNA and protein synthesis are linked or uncoupled in fermenting and respiring cells. Using motif predictions, interaction data and RNA profiling we find among them 28 likely targets for Ume6, a subunit of the conserved Rpd3/Sin3 histone deacetylase-complex regulating genes involved in metabolism, stress response and meiosis. Finally, we identify 14 genes for which both RNA and proteins are detected exclusively in respiring cells but not in fermenting cells in our sample set, including CSM4, SPR1, SPS4 and RIM4, which were thought to be meiosis-specific. Our work reveals intertwined transcriptional and post-transcriptional control mechanisms acting when a MATa/α strain responds to nutritional signals, and provides molecular clues how the carbon source primes yeast cells for entering meiosis. Our integrated genomics study provides insight into the interplay between the transcriptome and the proteome in diploid yeast cells undergoing vegetative growth in the presence of glucose (fermentation) or acetate (respiration). Furthermore, it reveals novel target genes involved in these processes for Ume6, the DNA binding subunit of the conserved histone deacetylase Rpd3 and the co-repressor Sin3. We have combined data from an RNA profiling experiment using tiling arrays that cover the entire yeast genome, and a large-scale protein detection analysis based on mass spectrometry in diploid MATa/α cells. This distinguishes our study from most others in the field-which investigate haploid yeast strains-because only diploid cells can undergo meiotic development in the simultaneous absence of a non-fermentable carbon source and nitrogen. Indeed, we report molecular clues how respiration of acetate might prime diploid cells for efficient spore formation, a phenomenon that is well known but poorly understood.
ISSN: 1874-3919

hal-01122122
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122122
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122122/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122122/file/Integrated%20RNA-%20and%20protein%20profiling%20of%20fermentation.pdf
DOI : 10.1016/j.jprot.2015.01.015

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BackgroundTo date, all studies conducted on breast cancer diagnosis have focused on the expression of the full-length 66-kDa estrogen receptor alpha (ERα66). However, much less attention has been paid to a shorter 46-kDa isoform (ERα46), devoid of the N-terminal region containing the transactivation function AF-1. Here, we investigated the expression levels of ERα46 in breast tumors in relation to tumor grade and size, and examined the mechanism of its generation and its specificities of coregulatory binding and its functional activities.MethodsUsing approaches combining immunohistochemistry, Western blotting, and proteomics, antibodies allowing ERα46 detection were identified and the expression levels of ERα46 were quantified in 116 ERα-positive human breast tumors. ERα46 expression upon cellular stress was studied, and coregulator bindings, transcriptional, and proliferative response were determined to both ERα isoforms.ResultsERα46 was expressed in over 70% of breast tumors at variable levels which sometimes were more abundant than ERα66, especially in differentiated, lower-grade, and smaller-sized tumors. We also found that ERα46 can be generated via internal ribosome entry site-mediated translation in the context of endoplasmic reticulum stress. The binding affinities of both unliganded and fully-activated receptors towards co-regulator peptides revealed that the respective potencies of ERα46 and ERα66 differ significantly, contributing to the differential transcriptional activity of target genes to 17β estradiol (E2). Finally, increasing amounts of ERα46 decrease the proliferation rate of MCF7 tumor cells in response to E2.ConclusionsWe found that, besides the full-length ERα66, the overlooked ERα46 isoform is also expressed in a majority of breast tumors. This finding highlights the importance of the choice of antibodies used for the diagnosis of breast cancer, which are able or not to detect the ERα46 isoform. In addition, since the function of both ERα isoforms differs, this work underlines the need to develop new technologies in order to discriminate ERα66 and ERα46 expression in breast cancer diagnosis which could have potential clinical relevance.
ISSN: 1465-5411

inserm-01412032
http://www.hal.inserm.fr/inserm-01412032
http://www.hal.inserm.fr/inserm-01412032/document
http://www.hal.inserm.fr/inserm-01412032/file/13058_2016_Article_780.pdf
DOI : 10.1186/s13058-016-0780-7

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
ISSN: 0002-9262

hal-01010674
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010674
DOI : 10.1093/aje/kwt315
PUBMED : 24401564

Éditeur(s) : HAL CCSD
Résumé : International audience
It is classically admitted that the goodfriction properties of lamellar compounds are strongly related to their anisotropic structure and especially to the existence of weak interlayer interactions through the van der Waals gap separating the basal layers. As it is also known, the presence of the van der Waals gap in the structure of lamellar compounds will allow lot of chemical species to be intercalated in the structure leading both to the expansion of structure parameters and inter layer interactions modifications. The present work is concerned with the experimental and theoretical study of friction propertiesof Graphite Intercalated Compounds (GICs) in order to better understand thetribologiclamellar compounds. In order to modulate the interlayer interactions, two types of intercalated species were used, electrophylic species (AlCl3, FeCl3, SbCl5) and nucleophilic species (Li, K, Rb).
40th Leeds-Lyon Symposium on Tribology & Tribochemistry Forum 2013
Lyon, France

Droits : info:eu-repo/semantics/OpenAccess
hal-00926509
https://hal.archives-ouvertes.fr/hal-00926509
https://hal.archives-ouvertes.fr/hal-00926509/document
https://hal.archives-ouvertes.fr/hal-00926509/file/Delbe_9781.pdf
OATAO : 9781

Éditeur(s) : HAL CCSD
International conference on Environmental Epidemiology and Exposure ISEE/ISEA
Paris, France

hal-00697382
https://hal.archives-ouvertes.fr/hal-00697382

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
In this study we attempt to understand the water storage variations in a karst aquifer on the Larzac Plateau (South of France) using ground-based gravimetry. Surface to 60 m depth gravity measurements are performed three times a year since 2006 down a pothole, in complement to monthly absolute gravity (AG) measurements at three sites. The time variations of the surface to depth (STD) gravity differences are compared with the AG variations. Using a simple Bouguer plate model, we find that the STD gravity differences are very similar to the AG variations. The STD gravity differences are then used to determine apparent density values. These integrative density values are compared with measured grain densities from core samples to obtain an apparent porosity and saturation change representative of the investigated depth. The apparent porosity ranges from 4.8 to 7.3 per cent. We then discuss on the repartition of the apparent physical properties with respect to the epikarst and infiltration zone karst structures. We argue that AG and STD differences monitor epikarst water storage variations. Within this scope, we discuss the fact that seasonal scale water storage variation occurs predominantly in the epikarst.
ISSN: 0956-540X

hal-00413528
https://hal.archives-ouvertes.fr/hal-00413528
DOI : 10.1111/j.1365-246X.2009.04118.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Iranian plateau is a flat ~ 1.5–2 km high plateau thought to result from the collision between the Arabian and Eurasian plates since ~ 30 ± 5 Ma, and may represent a young analogue to the so far better studied Tibetan plateau. In order to constrain the exhumation history of the internal Zagros and of the Iranian plateau, we herein present apatite (U-Th)/He (AHe) and apatite (AFT) and zircon fission-track (ZFT) data on plutonic rocks from the Sanandaj–Sirjan Zone (SSZ), Urumieh–Dokhtar magmatic arc (UDMA), Central Iran and Kopet Dagh. Thermochronologic data show that the SSZ was exhumed early in the collision process (essentially before 25–20 Ma), with a likely acceleration of cooling during the late Eocene, from 0.04 to 0.3 mm/year. Results suggest that cooling of the internal Zagros migrated from the SSZ to the UDMA during a more mature stage of the continental collision, after ~ 17 Ma (i.e., coeval with the outward propagation of deformation and topography fronts in the external Zagros). Constant exhumation rates in the UDMA (~ 0.3 mm/year) suggest that no significant variation of erosion rates occurred since the onset of continental collision. In Central Iran, the overlap of ZFT, AFT and AHe ages from gneissic samples points to rapid cooling during the late Eocene (~ 42 °C/Myr), which is consistent with previous reports on the formation of Eocene metamorphic core-complexes.
ISSN: 0024-4937

hal-01115691
https://hal.archives-ouvertes.fr/hal-01115691
DOI : 10.1016/j.lithos.2014.07.021

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The present work is concerned with the study of the tribological properties of various fluorinated carbon phases obtained at room temperature and then post-treated under fluorine atmosphere at different temperatures. The tribological tests evidence good intrinsic properties for all the compounds (friction coefficient in the range 0.07-0.09). Differences appear after few cycles. Friction measurements after 100 cycles and complementary Raman analyses of the tribofilm remaining in the wear scar point out that long term tribologic properties of the fluorinated compounds strongly depend on the evolution undergone by the materials under friction. The release of HF molecules, the loss of fluorine and partial rebuilding of graphitic phases are at the origin of the degradation of the friction properties. The good properties of the compounds post-treated at temperature in the range 150-300 °C are attributed to the chemical and structural stability of these compounds under friction.
ISSN: 0022-3697

hal-00756133
https://hal.archives-ouvertes.fr/hal-00756133
https://hal.archives-ouvertes.fr/hal-00756133/document
https://hal.archives-ouvertes.fr/hal-00756133/file/Delbe_6346.pdf
DOI : 10.1016/j.jpcs.2006.01.084

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The thermal evolution of sediments in the shallowest part of sedimentary basins is challenging to investigate as most of the geothermometers are at their application limits. This is typically the case of the Callovian-Oxfordian claystones at the eastern border of the Paris Basin. A recent 2000 m deep well penetrated the entire Jurassic and Triassic sedimentary series and permitted coring of sediments never reached by previous drilling in this part of the basin. Thanks to the use of several independent geothermometers (apatite fission track thermochronology, fluid inclusion microthermometry, clay mineralogy and sedimentary organic matter evolution) the burial history of the Mesozoic series has been reconstructed, modeled and calibrated using kinetic algorithms relevant to the various paleothermometers used. In addition to these conventional methods, an innovative approach was developed using the temperature-dependence of the magnetic mineral assemblage within clay-rich sediments ("MagEval"). Thermal modeling indicates that the Callovian-Oxfordian and the Lower Triassic experienced maximum burial temperatures of 50 +/- 5 C-circle and 90 +/- 10 C-circle respectively, i.e., about 25 C higher than present-day. This temperature offset implies the erosion of several hundred meters of sediments which, depending on the thermal flux and conductivity considered, most likely constituted Upper Cretaceous chalk deposits. Falling sea level resulted in the exposure and subsequent dismantling of the chalk cover at the beginning of Cenozoic times. The eastern border of the basin was then subjected to slow erosion and discrete tectonic deformation.
ISSN: 0264-8172

hal-01313142
https://hal.archives-ouvertes.fr/hal-01313142
DOI : 10.1016/j.marpetgeo.2013.08.019

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0257-8972

hal-01679413
https://hal.archives-ouvertes.fr/hal-01679413
DOI : 10.1016/j.surfcoat.2016.03.021

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
The levels and duration of physical activity that can be considered as completely safe in patients with sickle cell anemia (SCA) is unknown. The present study compared the hemorheological and hematological profile, cell density distribution and basic biochemistry between a group of 17 patients with SCA and 21 healthy subjects before and after a 20 min duration submaximal cycling exercise at the same absolute workload. Blood was sampled at rest and 3 min after the end of exercise for measurement of biological parameters. Exercise did not affect the hematocrit and blood viscosity in the two groups. Plasma viscosity was not different between the two groups at rest and similarly increased with exercise. The proportion of intermediary dense cells (with density between 1.11 and 1.12 g/ml) decreased with exercise in the SCA group resulting in an increase in the proportion of red blood cells with a density > 1.12 g/ml. No change was observed in the control group. The present study suggests that mild-moderate exercise is not very harmful for SCA patients. The hemorheological and hematological changes very mild, except for the formation of dense cells but no clinically significant signs of medical complication were present in any of the patients.
ISSN: 0007-1048

hal-00640629
https://hal.archives-ouvertes.fr/hal-00640629
https://hal.archives-ouvertes.fr/hal-00640629/document
https://hal.archives-ouvertes.fr/hal-00640629/file/PEER_stage2_10.1111%252Fj.1365-2141.2011.08728.x.pdf
DOI : 10.1111/j.1365-2141.2011.08728.x

Éditeur(s) : HAL CCSD American Chemical Society
Résumé : International audience
People spend a considerable amount of time indoors. As a result, exposure to indoor contaminants is of great concern, notably via settled dust ingestion in particular for infants and toddlers. This paper proposes a critical review on the organic contamination of settled house dust and human exposure over the past 10 years and focused on sources, contaminations and measurement methods (sampling, pretreatment, storage and analysis). As many compounds were identified, arises the question of which ones to consider. Sensitive and selective analytical methods for simultaneous determination of targeted substances should be developed and evaluated. Various methods were described for sampling and sample preparation. Harmonization and standardization are needed to enable comparison of results from similar studies. Finally, an integrated multipollutant and multicompartment (settled dust, suspended particles and air) approach appears essential in order to determine the extent of the threat to public health posed by indoor contaminants.
ISSN: 0013-936X

hal-00687396
https://hal.archives-ouvertes.fr/hal-00687396
DOI : 10.1021/es200925h
PUBMED : 21667945