Éditeur(s) : HAL CCSD American Society of Tropical Medicine and Hygiene
Résumé : International audience
Histoplasmosis is the first cause of acquired immunodeficiency syndrome (AIDS) and AIDS-related deaths in French Guiana. Cohort data were used to determine whether primary prophylaxis with 100 mg itraconazole for patients with CD4 counts < 150/mm(3) was cost-effective with different scenarios. For a scenario where 12% of patients died, 60% were aware of their human immunodeficiency virus (HIV) infection and adherence was only 50%, primary prophylaxis would prevent 1 death and 9 cases of histoplasmosis for a cost of 36,792 Euros per averted death, 1,533 per life-year saved, 4,415 Euros per averted case, when only counting the costs of itraconazole prophylaxis. Taking into account the total costs of hospitalization showed that primary prophylaxis would allow a savings of 185,178 Euros per year. Even in a scenario of low adherence, primary prophylaxis would be cost-effective in French Guiana, and presumably in the rest of the Guianas and the Amazon.
ISSN: 0002-9637

inserm-00913886
http://www.hal.inserm.fr/inserm-00913886
http://www.hal.inserm.fr/inserm-00913886/document
http://www.hal.inserm.fr/inserm-00913886/file/2013_Nacher_-_Primary_prophylaxissur disseminated_histoplasmosis_in_HIV_patients_in_French_Guiana_a_cost_effectiveness_study.pdf
DOI : 10.4269/ajtmh.13-0082

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Les effets de la crise du capitalisme se sont traduits en Guadeloupe en janvier 2009 par un mouvement social sans précédent, dirigé par un collectif qui a suscité l’adhésion en raison de son expression du malaise social et de la gestion des revendications adressées au gouvernement. Ce mouvement social est innovant en Guadeloupe en raison de la pluralité des acteurs et de la nature de ses revendications. C’est donc sur son sens qu’il convient de s’interroger. Une société civile s’est réveillée créant de nouveaux espaces de débat.
Capitalism’s crisis effects resulted in social movement unprecedented led by a group that mobilized in the style of expressing unrest and managing demands that were sent to French government. This social movement is new in Guadeloupe because of variety actions and type of demands. It’s therefore necessary to consider its meaning: a civil society woke up creating new spaces for debate.
Guadeloupe

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.4898
http://journals.openedition.org/etudescaribeennes/4898

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
GenMol (TM) code is used to simulate Atomic Force Microscopy (AFM) tests at a kaolinite/brine/kaolinite contact, the confined fluid in sub-nanometre interspaces being in equilibrium with an external multi-species solution. The attraction/repulsion effort, i.e. the derivative versus the interspace aperture h of the interaction energy between both kaolinite faces, is computed versus the variable composition of the confined fluid (see for the method Part I of this work). Two external solutions are tested. Solution Si is a neutral brine (pH=7.5) leading to a possible attraction for apertures lower than 7 angstrom. Solution S2 is an acidified brine (pH=3.2) leading to repulsion whatever may be the aperture h. These two AFM simulations prove the existence of a critical pH value (3.2 < pH(crit) < 7.5) of the external solution, below which the acidification of a natural brine in a CO2 confinement inhibits adhesion between kaolinite aggregates.
ISSN: 0022-0248

hal-00544678
https://hal.archives-ouvertes.fr/hal-00544678
DOI : 10.1016/j.jcrysgro.2010.08.012

Éditeur(s) : Université des Antilles
Extrait de : "La Guadeloupe au sein de l'organisation des Etats de la Caraïbe orientale : une adhésion pour quoi faire ?" : journées d'étude, le 28 février et le 15 mars 2019. Université des Antilles
Description : Une adhésion pour quelle stratégie de coopération régionale ? La signature de l?accord d?adhe?sion entre l?OECO et la Guadeloupe s?inscrit dans un cadre de rapprochement multilate?ral et se justifie par la ne?cessite? de renforcer, nos capacite?s collectives dans le domaine de la santé, le changement climatique et la gestion des risques.
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V19053
V19053

Éditeur(s) : HAL CCSD American Society of Hematology
Résumé : International audience
Sickle cell disease is characterized by painful vaso-occlusive crises during which abnormal interactions between erythroid adhesion molecules and vessel-wall proteins are thought to play a critical role. Hydroxyurea, the only drug with proven benefit in sickle cell disease, diminishes these interactions, but its mechanism of action is not fully understood. We report that, under hydroxyurea, expression of the unique erythroid laminin receptor Lu/BCAM was increased, but red blood cell adhesion to laminin decreased. Because Lu/BCAM phosphorylation is known to activate cell adhesion to laminin, it was evaluated and found to be dramatically lower in hydroxyurea-treated patients. Analysis of the protein kinase A pathway showed decreased intracellular levels of the upstream effector cyclic adenosine monophosphate during hydroxyurea treatment. Using a cellular model expressing recombinant Lu/BCAM, we showed that hydroxyurea led to decreased intracellular cyclic adenosine monophosphate levels and diminished Lu/BCAM phosphorylation and cell adhesion. We provide evidence that hydroxyurea could reduce abnormal sickle red blood cell adhesion to the vascular wall by regulating the activation state of adhesion molecules independently of their expression level.
ISSN: 0006-4971

inserm-00821117
http://www.hal.inserm.fr/inserm-00821117
http://www.hal.inserm.fr/inserm-00821117/document
http://www.hal.inserm.fr/inserm-00821117/file/Bartolucci_Blood_2010.pdf
DOI : 10.1182/blood-2009-12-257444

Résumé : Water was applied to the limestone and was absorbed by the etched sect-ions of the stone. When applied, printing ink for that color adhered only to the image on the stone. Damp paper from the proof book was then pressed to the stone and an image was produced in the color represented by that stone. The same process was repeated for each color in the design (as many as 13 colors were used), the lithographer carefully registering the same piece of paper on each separate stone. Each separate color used in the image required its own stone!
(Funding) Funded in part by the Institute for Museum and Library Services (IMLS), Ephemeral Cities Project.
Tampa |z 1271000 |2 ceeus
Hillsborough County |z 12057 |2 ceeus
United States of America -- Florida -- Hillsborough County -- Tampa

Droits : All rights reserved. 2005.
C24-05663

Éditeur(s) : HAL CCSD
Résumé : The spectrin-based skeleton is an essential scaffold underlying different lipid bilayers in all animal cells. Spectrins (Sp), as giant extended flexible heterotetramers (αβ)2, constitute the filaments of this network, the nodes of which are cross-linked by actin filaments. The functions of the Sp-based skeleton, which are well defined in red blood cells (required for shape, resistance to shear stress and deformability) are less well understood in non-erythroid cells.The non-erythroid Sp might participate in the establishment and/or the maintenance of specialized membrane subdomains by accumulating integral membrane proteins (such as ionic channels, ionic pumps, receptors and cell adhesion molecules) as revealed by loss of the main non-erythroid β-Sp. However the effect of non-erythroid α-Sp are less well established. In mammals, α-Sp are encoded by two genes: one for αI-Sp mainly expressed in mature erythrocyte, the second one for αII-Sp which is expressed in all nucleated cells.In the pursuit of αII-Sp functions, we have checked the effect of αII-Sp knock down by siRNA melanoma human cell line. Our data revealed that spectrin depletion is associated with i) an arrest of cell cycle at G1 state ii) a loss of cell adhesion in spite of increase in some integrins iii) some modifications of actin organisation.
Le squelette dépendant de la spectrine, localisé sous la bicouche lipidique, est un échafaudage essentiel de toutes les cellules animales. La Spectrine (Sp), structure géante, robuste mais flexible d'hétéro tétramères (αβ)2, constitue les filaments de ce réseau, dont chaque nœud interagit avec des filaments d'actine. Les fonctions du squelette de Sp, qui sont bien définies dans le globule rouge (rôle dans sa forme, dans sa résistance aux forces de cisaillement et dans sa déformabilité) sont moins bien connues dans les cellules non-érythroïdes. La Sp non-érythroïde pourrait participer à l'établissement et/ou au maintien de sous-domaines membranaires spécialisés dans l'accumulation de protéines de membrane (telles que les canaux ioniques, les pompes ioniques, les récepteurs et les molécules d'adhérence) comme nous le font penser les invalidations de la Sp-β non-érythroïde. Cependant le rôle de la Sp-α non-érythroïde est moins bien établi. Chez les mammifères, la Sp-α est codée par deux gènes: un pour Sp-αI, principalement exprimée dans l'érythrocyte mature, le second pour Sp-αII qui est exprimée dans toutes les cellules nucléées. Pour étudier les fonctions de la Sp-αII, nous avons utilisé une approche de SiRNA sur des cellules de mélanome humain. Nos données montrent que la diminution de Sp-αII est associée à I) un arrêt en G1 du cycle cellulaire II) une perte d'adhérence des cellules malgré l'augmentation de quelques intégrines III) des modifications dans l'organisation du réseau d'actine.
https://tel.archives-ouvertes.fr/tel-00377569

Droits : info:eu-repo/semantics/OpenAccess
tel-00377569
https://tel.archives-ouvertes.fr/tel-00377569
https://tel.archives-ouvertes.fr/tel-00377569/document
https://tel.archives-ouvertes.fr/tel-00377569/file/these_210409_entiere.pdf
https://tel.archives-ouvertes.fr/tel-00377569/file/II-Spectrin_Is_Critical_for_Cell_Adhesion_and_Cell_Cycle.PDF

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Plasmodium vivax malaria is an important public health issue in the Amazon region, and it accounts for approximately 84 % of cases of the disease. Migration across the border between Brazil and French Guiana contributes to the maintenance of the disease. The aim of this study was to evaluate the therapeutic and parasitological responses of patients with P. vivax malaria treated with chloroquine and primaquine in the socio-environmental context of cross-border interactions between Brazil and French Guiana. The factors controlled were diagnostic agreement, adherence, adjustment of primaquine doses for patient weight, and quality of the drugs used. A prospective study was conducted in 2011 with 103 individuals aged 10-60 years with a positive diagnosis of P. vivax treated with chloroquine (10 mg base/kg on the first day, followed by 7.5 mg/kg on the second and third days) and primaquine for 7 days, who were followed for 28 days. The primaquine doses were adjusted for the patients' weight. A number of factors were determined: epidemiological characteristics, origin of patients, signs and symptoms, initial parasitaemia and parasitaemia clearance time, blood concentrations of chloroquine and primaquine, quality of anti-malarial drugs and diagnostic agreement. Ninety-five patients were followed for 28 days. There was a 100 % agreement in microscopic diagnosis between field laboratory and reference centre. The adhesion to the treatment was 100 %. Of these patients, 32.6 % received a weight-adjusted dose of primaquine. The chloroquine and primaquine tablets were consistent with the optimal quality limits for human consumption. The investigated patients achieved optimal blood exposure to anti-malarial drugs. The parasitological and therapeutic response was adequate in 99.0 % of cases. In the municipality of Oiapoque, the therapeutic regime used for the treatment of P. vivax malaria using chloroquine combined with primaquine remains effective, when external factors are controlled, such as the quality of anti-malarial drugs, the adhesion to the treatment prescribed, the correct diagnostic and the adjustment of primaquine dose for patient body weight.
ISSN: 1475-2875

Droits : http://creativecommons.org/licenses/by/
pasteur-01229355
https://hal-pasteur.archives-ouvertes.fr/pasteur-01229355
https://hal-pasteur.archives-ouvertes.fr/pasteur-01229355/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-01229355/file/s12936-015-0925-7.pdf
PUBMEDCENTRAL : PMC4600333

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Predicting the impact of underground engineering on the environment requires the knowledge of natural media at different scales. In particular, understanding basic phenomena controlling the properties of rocks in the presence of complex fluids necessitates a detailed atomic description of the solid/fluid/solid contacts, the subject of Part I of the present study. First, building the solid interspace between two different crystals in a non-periodic situation is achieved using the ab initio and molecular mechanics code GenMol (TM). A description of the fluid confined within the interspace is then derived from the original genetic iterative multi-species (GIMS) algorithm implemented in the same code. This approach consists of equilibrating chemical potentials, cycle after cycle and species after species, between the confined fluid and the free natural fluid. An elementary iteration for a species k consists of different steps incrementing the number N-k of particles k, with other numbers N-k remaining constant. At each step, an optimum fluid composition is obtained by a genetic process distributing the fluid particles on a grid by stochastic shots, followed in fine by a refining process. The effectiveness of the GIMS approach is demonstrated in the case study of a fluid confined between two (0 0 1) kaolinite faces, with apertures h varying between 4 and 10 A. connected to a 9-species external solution [H2O, Cl-, Na+ CO2(aq), NaCl(aq), Ca2+, Mg2+, HCO3-, H3O+] where concentrations are ranging from 55 to 10(-4) mol/L. The results show a drastic variation in the solute/solvent and cations/ions ratios in the confined fluid when aperture h is lowered to less than 1 nm. These results obtained with a very rapid convergence of the iterative algorithm combined with a very competitive genetic optimizer are validated with high precision on a free solution. This description of contacts between crystals is original and unattainable by standard crystal interface approaches. It opens the way to understanding and/or predicting phenomena between crystals in a complex natural environment, such as adhesion or repulsion investigated in the Part II of this study.
ISSN: 0022-0248

hal-00544569
https://hal.archives-ouvertes.fr/hal-00544569
DOI : 10.1016/j.jcrysgro.2010.08.009

Éditeur(s) : HAL CCSD Ferrata Storti Foundation
Résumé : International audience
BACKGROUND: Abnormal interactions between red blood cells, leukocytes and endothelial cells play a critical role in the occurrence of the painful vaso-occlusive crises associated with sickle cell disease. We investigated the interaction between circulating leukocytes and red blood cells which could lead to aggregate formation, enhancing the incidence of vaso-occlusive crises. DESIGN AND METHODS: Blood samples from patients with sickle cell disease (n=25) and healthy subjects (n=5) were analyzed by imaging and classical flow cytometry after density gradient separation. The identity of the cells in the peripheral blood mononuclear cell layer was determined using antibodies directed specifically against white (anti-CD45) or red (anti-glycophorin A) blood cells. RESULTS: Aggregates between red blood cells and peripheral blood mononuclear cells were visualized in whole blood from patients with sickle cell disease. The aggregation rate was 10-fold higher in these patients than in control subjects. Both mature red blood cells and reticulocytes were involved in these aggregates through their interaction with mononuclear cells, mainly with monocytes. The size of the aggregates was variable, with one mononuclear cell binding to one, two or several red blood cells. Erythroid Lu/basal cell adhesion molecule and α(4)β(1) integrin were involved in aggregate formation. The aggregation rate was lower in patients treated with hydroxycarbamide than in untreated patients. CONCLUSIONS: Our study gives visual evidence of the existence of circulating red blood cell-peripheral blood mononuclear cell aggregates in patients with sickle cell disease and shows that these aggregates are decreased during hydroxycarbamide treatment. Our results strongly suggest that erythroid Lu/basal cell adhesion molecule proteins are implicated in these aggregates through their interaction with α(4)β(1) integrin on peripheral blood mononuclear cells.
ISSN: 0390-6078

inserm-00821120
http://www.hal.inserm.fr/inserm-00821120
http://www.hal.inserm.fr/inserm-00821120/document
http://www.hal.inserm.fr/inserm-00821120/file/1841.full.pdf
DOI : 10.3324/haematol.2010.026294

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
A feasibility study of glulam was carried out in French Guiana using local wood species. The aim was to determine gluing parameters affording satisfactory behaviour to manufactured glulam in a tropical climate. Three abundant wood species, with special properties, were selected for the study and Resorcinol-Phenol-Formaldehyde resin was used for bonding. Three industrial parameters were considered: adhesive spread rate, closed assembly time and gluing pressure. Delamination and shearing tests were carried outin accordance with European Standards. The tests revealed the influence of wood properties and manufacturing parameters on joint resistance. In fact, the results showed that specific gravity and the shrinkage coefficientgreatly influenced the gluing step. Indeed, wood with a medium specific gravity needed more adhesive and more pressure than wood with a high specific gravity. In addition, planning and lamella thicknesswere found to affect glue joint resistance.
ISSN: 0018-3768

hal-00856933
https://hal.archives-ouvertes.fr/hal-00856933
https://hal.archives-ouvertes.fr/hal-00856933/document
https://hal.archives-ouvertes.fr/hal-00856933/file/Feasibility_glued_laminated_timber_Bourreau_al.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Objectives: To assess the adhesion of French obstetricians and gynecologists to the French clinical practice guidelines for pregnancy loss, issued by the French College of Obstetricians and Gynecologists, one year after publication.Methods: An online vignette-based study was emailed to a sample of French obstetricians and gynecologists to compare their management of women with missed early miscarriage and incomplete early miscarriage. A descriptive statistical analysis was performed comparing the rates of appropriate management for these two indications before and after the release of the guidelines.Results: Of the 404 specialists contacted, 143 completed the questionnaire. Forty-three percent stated that they had changed their practices following the release of the guidelines. The rate of adhesion was moderate for the management of missed early miscarriage (53% after publication of the guidelines versus 42% before, P = 0.001) with a trend to avoid watching-and-waiting management. The rate of adhesion was poor for the management of incomplete early miscarriage (43% after the publication of the guidelines versus 27% before, P < 0.001) with a lower use of misoprostol.Conclusion: Adhesion to the French guidelines appears to be moderate for the management of missed early miscarriage and low for the management of incomplete early miscarriage.
ISSN: 24687847

hal-01558814
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01558814
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01558814/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01558814/file/Le%20Gouic%20et%20al.%20-%20Evaluation%20of%20adherence%20to%20French%20clinical%20practic.pdf
DOI : 10.1016/j.jogoh.2017.03.005

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Properties of composite materials depend on interatomic phenomena occurring between binder crystals. Experimental information of Atomic Force Microscopy (A.F.M.) is of prime importance; however understanding is helped by molecular modeling. As underlined in Section 1, the present study is able to simulate crystal interfaces in presence of a solution within apertures less than 1 Nanometer at a full atomic scale. Section 2 presents the case study of a gypsum solution between (120) gypsum faces, with related boundary conditions and atomic interactions. Section 3 deals with the mass equilibrium of the solution within interfaces <5 angstrom, using the original Semi Analytical Stochastic Perturbations (SASP) approach. This information becomes in Section 4 the key for explaining the peak of adhesion obtained in A.F.M. around an aperture of 3 A and gives enlightenments on gypsum cohesion. In conclusion, this illustration shows the potentialities of full atomic modeling which could not be attained by any numerical approach at a mesoscopic scale.
ISSN: 0008-8846

hal-00411868
https://hal.archives-ouvertes.fr/hal-00411868
DOI : 10.1016/j.cemconres.2007.09.022

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Le 26 septembre 2007, lors d’un discours à l’Assemblée générale des Nations Unies, Rafael Correa, le président équatorien, critiqua la vision du développement sous-jacente aux Objectifs du Millénaire pour le Développement (OMD). Récusant la stratégie de libéralisation économique et les objectifs d’accroissement de la consommation qu’elle implique, son gouvernement s’est prononcé en faveur d’un « développement endogène, d’inclusion économique et de cohésion sociale et territoriale » afin de diminuer les inégalités pour permettre à tous de mener une vie décente et digne, ajoutant « notre vision du développement est très différente : nous entendons par développement le bien-être de tous, en paix et en harmonie avec la nature, et la prolongation infinie des cultures humaines. »Le tourisme, source majeure de devises étrangères en Équateur à côté du pétrole et des envois d’argent des migrants, peut-il contribuer à l’atteinte de cet objectif ? Comment ? Atteignant plus d’un million de visiteurs étrangers en 2008 (dont 24 % en provenance des États-Unis et 45 % de pays d’Amérique latine, les recettes du tourisme international ont représenté la même année, 754 millions de dollars. Considérant le tourisme comme une activité opportune, de plus en plus de communautés autochtones développent des projets touristiques. En 2009, la fédération plurinationale de tourisme communautaire d’Équateur regroupait 90 communautés membres alors même que toutes celles qui développent des projets de tourisme communautaire n’adhèrent pas à la fédération. Comment comprendre cet engouement pour le tourisme de la part des communautés autochtones ? Quelles sont leurs attentes ? Les projets permettent-ils d’y répondre ? Nous apporterons des éléments de réponse à ces questions à travers l’analyse de deux expériences de tourisme communautaire menées par des communautés quechuas dans les Andes et en Amazonie.
In September 2007, during a speech to the General Assembly of the United Nations, Ecuadorian president Rafael Correa criticized the vision underlying the Millennium Development Goals (MDGs). Rejecting the strategy of economic liberalization and the increased consumption it implies, Correa stated that his government was in favour of "endogenous development, economic inclusion and social and territorial cohesion" to reduce inequalities and permit a decent standard of life for everyone, adding "our vision of development is very different: we believe in developing the welfare of all, in peace and harmony with nature, and the infinite extension of human cultures."Tourism is one of the largest form of foreign exchange in Ecuador beside oil and remittances from migrants. Can tourism contribute to achieving the goal defined by Correa? How? With more than one million foreign visitors in 2008 (including 24% from the United States and 45% from Latin American countries), international tourism contributed $745 millions to Ecuador’s economy in 2008. Acknowledging tourism as a timely activity, more and more indigenous communities are developing tourism projects. The multinational federation of community-based tourism in Ecuador includes 90 communities, even though all those who set up community tourism projects have not adhered to the federation’s requirements. How can we understand this surge in popularity for tourism from indigenous communities and what are their expectations? Do these projects result in adequate solutions? We will provide some answers through the analysis of two experiments conducted on community-based tourism by Kechua communities in the Andes and the Amazon rainforest.
Équateur

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.6551
http://journals.openedition.org/etudescaribeennes/6551

Éditeur(s) : HAL CCSD
Résumé : The present PhD thesis is devoted to the numerical simulation and analysis of shear on cohesive granular materials. In the framework of the Contact Dynamics method, we developed a model of cohesive bonding, which mimics cohesion by cementation. This model involves three contact strength parameters (a tensile strength, a coefficient of sliding friction, and a coefficient of rolling friction) as well as a local criterion, which controls the creation and the breaking of cohesive bonds. All contacts are cohesive at the beginning of the numerical simulations, and contact rupture leads to an irreversible loss of tensile strength (debonding). We varied systematically the three contact strength parameters and studied their influence on the shear strength, the dilatancy, and the microstructure of the granular media. Our results show that internal friction and macroscopic tensile strength have different origins at the contact scale. We also find that the microstructure of the granular media, when sheared at the steady state (also known as the `critical state"), is strongly affected by the local coefficients of sliding and rolling friction. In particular, the mechanical role of the weak network changes with these two contact parameters, which results from the formation of a new structure of force transmission. On the other hand, we also applied the same numerical simulation method to the simulation of landslides. We developed a methodology, which takes into account the initial morphology of the hillslope, the strength of geomaterials, and a triggering factor, integrating in the same model the initiation and propagation phases of the landslide. To illustrate this methodology, we applied it to the simulation of a hypothetical example of avalanche triggered by the progressive rise of a water table.
Ce travail de thèse porte sur la modélisation numérique et l'analyse du cisaillement dans les milieux granulaires cohésifs. Dans le cadre de la méthode de la Dynamique des Contacts, nous avons développé un modèle de cohésion qui cherche à imiter la cohésion par cimentation. Ce modèle fait intervenir trois paramètres de résistance au niveau des contacts (une résistance à la traction, un coefficient de frottement de glissement, et un coefficient de frottement de roulement) ainsi qu'un critère de création et de rupture des liens cohésifs. Les contacts sont cohésifs au début des simulations et leur rupture entraîne la perte irréversible de la résistance à la traction. Nous avons fait varier les trois paramètres microscopiques et nous avons étudié leur influence dans la résistance au cisaillement, la dilatance, et la microstructure du milieu. Nos résultats montrent que le frottement interne et l'adhésion macroscopiques ont des origines microscopiques différentes. Nous observons aussi que la microstructure du milieu cisaillé à l'état stationnaire (aussi connu comme ``l'état critique") est fortement affectée par l'angle de frottement et la résistance au roulement au niveau des contacts. En particulier, le rôle mécanique du réseau faible change avec ces deux paramètres microscopiques, ce qui résulte de la formation d'une nouvelle structure de transmission de forces. D'autre part, nous avons appliqué cette méthode de simulation numérique à l'étude d'un processus naturel : les glissements de terrain. Nous avons développé une méthodologie qui tient compte de la morphologie initiale du système, de la résistance des géomatériaux, et d'un mécanisme de déclanchement, ce qui permet d'intégrer dans le même modèle les phases d'initiation et de propagation du glissement. Pour illustrer cette méthodologie, nous l'avons appliquée à la modélisation d'un exemple hypothétique d'avalanche déclenchée par la montée progressive du niveau d'une nappe d'eau.
https://tel.archives-ouvertes.fr/tel-00311303

tel-00311303
https://tel.archives-ouvertes.fr/tel-00311303
https://tel.archives-ouvertes.fr/tel-00311303/document
https://tel.archives-ouvertes.fr/tel-00311303/file/these_estrada.pdf

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Depuis désormais plus de deux décennies d’existence, le Parc National de la Guadeloupe connait un renouveau, mais surtout des bouleversements de tous ordres (sociaux, économiques, culturels, politiques et juridiques) avec la réforme du régime des parcs nationaux français. D’instrument de protection intégrale, il est devenu un instrument de protection intégrée, vecteur de développement durable. Malgré les critiques, les avancés dans le régime de conservation sont bien présentes. Dans la famille des parcs nationaux d’Outre-Mer, le Parc national de la Guadeloupe est le « frère ainé ». Pour lui, la réforme représente une évolution, mais dans quel sens ?
Since now more than two decades of its existence, after the reform of the legal regime of national parks, the National Park of Guadeloupe faces a renewal and challenges of all kinds (social, economic, cultural, political and legal). A tool for protection has become an instrument for integration, vector of the sustainable development. Despite the criticisms, progresses in the conservation regime are present. However, their efficacy may be limited, owing to its facultative applicability to France of the Overseas. In the family of National Parks from overseas, the National Park of Guadeloupe is the elder brother. For PNG this represents an improvement, but in what direction?
Guadeloupe

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.3587
http://journals.openedition.org/etudescaribeennes/3587

Éditeur(s) : Université des Antilles. Service commun de la documentation Université des Antilles. Service commun de la documentation
Extrait de : "Au bord de l'espoir : Haïti et la République dominicaine" : conférence, le 11 octobre 2016, Université des Antilles
Description : La façon dont la République dominicaine traite les migrants haïtiens et les citoyens dominicains d?origine haïtienne a dominé la problématique des droits humains en 2015. Les autorités gouvernementales continuent à faire suite à une décision prise par la Cour constitutionnelle en 2013, et qui avait privé de leur nationalité des dizaines de milliers de Dominicains issus de familles migrantes, pour la plupart originaires d?Haïti, en menant une double politique consistant à réenregistrer les citoyens déchu de leur nationalité tout en pratiquant des expulsions massives. Dans le même temps, le gouvernement a pour la première fois engagé un effort global pour régulariser le statut des migrants sans papiers, pour la plupart Haïtiens. En novembre 2014, la Cour constitutionnelle a également mis en danger l?ensemble des protections des droits humains en déclarant inconstitutionnelle l?adhésion du gouvernement en 1999 à la juridiction de la Cour interaméricaine des droits de l?homme. Cette décision a créé un vide juridique qui n?a toujours pas été résolu.
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V17009
V17009
V17009

Éditeur(s) : HAL CCSD American Society for Cell Biology
Résumé : International audience
Based on its shedding and binding activities, the disintegrin and metalloprotease 12 (ADAM12) has been implicated in cell signaling. Here we investigate the intracellular protein interaction network of the transmembrane ADAM12L variant using an integrative approach. We identify the integrin-linked kinase (ILK) as a new partner for ADAM12L cellular functions. We demonstrate that ADAM12L coimmunoprecipitates with ILK in cells and that its cytoplasmic tail is required for this interaction. In human cultured hepatic stellate cells (HSCs), which express high levels of endogenous ADAM12L and ILK, the two proteins are redistributed to focal adhesions upon stimulation of a β1 integrin-dependent pathway. We show that down-regulation of ADAM12L in HSCs leads to cytoskeletal disorganization and loss of adhesion. Conversely, up-regulation of ADAM12L induces the Akt Ser-473 phosphorylation-dependent survival pathway via stimulation of β1 integrins and activation of phosphoinositide 3-kinase (PI3K). Depletion of ILK inhibits this effect, which is independent of ADAM12L proteolytic activity and involves its cytoplasmic domain. We further demonstrate that overexpression of ADAM12L promotes kinase activity from ILK immunoprecipitates. Our data suggest a new role for ADAM12L in mediating the functional association of ILK with β1 integrin to regulate cell adhesion/survival through a PI3K/Akt signaling pathway.
ISSN: 1059-1524

Droits : info:eu-repo/semantics/OpenAccess
inserm-00717429
http://www.hal.inserm.fr/inserm-00717429
http://www.hal.inserm.fr/inserm-00717429/document
http://www.hal.inserm.fr/inserm-00717429/file/MBoC_E11-11-0918R-A_LEYME_ET_AL.pdf
PUBMED : 22767580

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : La construction de l’Europe de l’éducation ne peut se faire sans que les acteurs des différents systèmes éducatifs ne puissent tenir compte des particularités propres à chaque état — par exemple le statut des langues régionales. Dans les régions ultrapériphériques de L’Europe — et particulièrement dans les départements français d’Amérique (D.F.A) — du fait du passé colonial de celles-ci, la question de l’éducation se pose avec beaucoup d’acuité. Cet article a pour ambition d’appréhender l’objet éducation dans un contexte de crispation identitaire, dans ces régions que l’on qualifie (abusivement) d’Europe tropicale.
According to the author, it’s impossible to consider the construction of the Europe of education without a real understanding of each member state particularities — for instance the status of regional languages. In the ultra-peripherical areas of Europe, mainly in the French overseas departments of America, because of their colonial past, the educational problem must be keenly approached. The ambition of this article aims to shed a light on the way the education project must be tackled in a special context of an irritating identity denial, in those areas, wrongly called, tropical Europe.

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.1002
http://journals.openedition.org/etudescaribeennes/1002

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Objective: To describe characteristics and outcomes of HIV-infected patients with Pneumocystis jirovecii pneumonia (PCP) over 2004–2011 in France, in particular in those previously enrolled (PE) in the French Hospital Database on HIV (FHDH). Methods: PE patients with an incident PCP were compared with patients with an inaugural PCP revealing HIV infection (reference). Adequate adherence to care was defined as a CD4 measurement at least every 6 months. Immune reconstitution (CD4$200/mm 3) and risk of death were studied using Kaplan-Meier estimates and multivariable Cox proportional hazards models. Results: In a context of a decreasing incidence of PCP, 1259 HIV-infected patients had a PCP diagnosis, and 593 (47%) were PE patients of whom 161 (27%) have had a prior history of AIDS-defining clinical illness (prior ADI). Median time since enrolment was 8 years for PE patients; 74% had received cART. Median proportion of time with adequate adherence to care was 85% (IQR, 66–96) for all FHDH enrollees, but only 45% (IQR, 1–81) for PE patients during the 2 years before PCP. Median CD4 cell count (38/mm 3) and HIV viral load (5.2 log10 copies/ml) at PCP diagnosis did not differ between PE patients and the reference group. Three year mortality rate of 25% was observed for PE prior ADI group, higher than in PE non-prior ADI group (8%) and the reference group (9%) (p,0.0001). In the PE prior ADI group, poor prognosis remained even after adjustment for virological control and immune reconstitution (HR, 2.4 [95%CI, 1.5–3.7]). Conclusion: Almost 50% of PCP diagnoses in HIV-infected patients occurred presently in patients already in care, mainly with a previous cART prescription but with waning adherence to care. Having repeated ADI is contributing to the risk of death beyond its impact on immune reconstitution and viral suppression: special efforts must be undertaken to maintain those patients in care.
ISSN: 1932-6203

Droits : http://creativecommons.org/licenses/by/
hal-01345090
http://hal.upmc.fr/hal-01345090
http://hal.upmc.fr/hal-01345090/document
http://hal.upmc.fr/hal-01345090/file/journal.pone.0094183.PDF
DOI : 10.1371/journal.pone.0094183