Éditeur(s) : HAL CCSD IOP Publishing
Résumé : The Bureau International des Poids et Mesures (BIPM), Sevres, France, hosted the 7th International Comparison of Absolute Gravimeters (ICAG) and the associated Relative Gravity Campaign (RGC) from August to September 2005.;ICAG 2005 was prepared and performed as a metrological pilot study, which aimed:;(1) To determine the gravity comparison reference values;;(2) To determine the offsets of the absolute gravimeters; and;(3) As a pilot study to accumulate experience for the CIPM Key Comparisons.;This document presents a complete and extensive review of the technical protocol and data processing procedures. The 1st ICAG-RGC comparison was held at the BIPM in 1980-1981 and since then meetings have been organized every 4 years.;In this paper, we present an overview of how the meeting was organized, the conditions of BIPM gravimetric sites, technical specifications, data processing strategy and an analysis of the final results. This 7th ICAG final report supersedes all previously published reports.;Readings were obtained from participating instruments, 19 absolute gravimeters and 15 relative gravimeters. Precise levelling measurements were carried out and all measurements were performed on the BIPM micro-gravity network which was specifically designed for the comparison.
ISSN: 0026-1394

hal-00644529
https://hal.archives-ouvertes.fr/hal-00644529
DOI : 10.1088/0026-1394/48/5/003

Éditeur(s) : HAL CCSD
Résumé : CorseAlp 2011 was held in April 2011. A link to the website is here: CorseAlp 2011. The CorseAlp field trips were designed to introduce the participants to the general features of the geology of Alpine Corsica and to recent specific discoveries. The three-day post-workshop field trip (Field trip 2) focused on the general architecture of Alpine Corsica in an EW transect between the Balagne region and Bastia. First day: The internal zones of Alpine Corsica: from Bastia to Saint Florent. Intinerary: Saint Florent, Serra di Pigno, Cima Malaspina, Patrimonio, Saint Florent. Second day: The Tenda massif and its eastern margin. Intinerary: Saint Florent, Casta, Fontana Porragghia, Rue de Morello, Fontana a Murello quarry; Fornali. Third day: The external zones of Alpine Corsica in the Balagne region. Intineray: Saint Florent, Colle di U'Vezzu, Ostriconi, Belgodere, San Sebastiano Chapel, San Colombano, Ponte Leccia, Francardo, Bastia.
Journal of the Virtual Explorer

hal-00688971
https://hal.archives-ouvertes.fr/hal-00688971

Éditeur(s) : HAL CCSD Endocrine Society
Résumé : International audience
: Context:Masculinization depends on the fetal testis. Exposure of the human fetus during pregnancy to paracetamol or/and to other mild-analgesics is associated with an increased risk of cryptorchidism.Objective:We aimed at determining whether mild analgesics disrupted the morphology and endocrine function of the human testis.Design:We used an in vitro system based on the culture of human fetal testes exposed or not to paracetamol, its metabolite AM404, aspirin, indomethacin, ketoconazole at 10(-4) M to 10(-7) M.Setting:The study was conducted at the University of Rennes I.Patients/Participants:Human fetal testes were from pregnant women following induced abortion, between 7 and 12 weeks of gestation (GW).Main Outcome Measures:Testosterone (radioimmunoassay: RIA), Anti-Müllerian Hormone (AMH; ELISA), insulin-like factor 3 (INSL3; RIA), prostaglandin D2 and E2 (PGD2 and PGE2, respectively; ELISA), were assayed in the media. Testicular cells were counted using histology and image analysis. The possible nuclear receptor-mediated activities of the analgesics were investigated using reporter cell lines expressing estrogen (ERs), androgen (AR) and peroxysome proliferator-activated γ ( PPARγ) receptors.Results:Indomethacin and aspirin stimulated testosterone production, particularly by the younger testes (8-9 GW vs 10-12 GW). Paracetamol, AM404 and ketoconazole decreased INSL3 levels. Aspirin stimulated, whereas ketoconazole inhibited AMH production. PGE2 levels were inhibited by paracetamol, and aspirin in the 7-12 GW testes, and by indomethacin but only in 7-9.86 GW old testes. The inhibitory trends seen for PGD2 were not statistically significant.Conclusions:Analgesics at concentrations relevant to human exposure cause endocrine disturbances in the fetal testis. We suggest that the fetal human testis displays slight critical age windows for sensitivity to direct exposure to aspirin, indomethacin and paracetamol. The analgesic-induced inhibition of INSL3 may be the mechanism by which analgesics increase the risk of cryptorchidism. Greater caution is required concerning consumption of analgesics during pregnancy.
ISSN: 0021-972X

inserm-00876125
http://www.hal.inserm.fr/inserm-00876125
DOI : 10.1210/jc.2013-2531
PUBMED : 24030937

Éditeur(s) : HAL CCSD
Résumé : Journée d'études du 27/04/17 « Révolution, dictature, résistance dans le monde américano-caraïbe »
Située au nord de Trinidad et Tobago, l'île de la Grenade fait partie de ces nations caribéennesaujourd'hui indépendantes dont l'histoire révolutionnaire a été singulièrement marquée par lacolonisation, l'esclavage, et plus récemment, par l'interventionnisme américain, au même titre quel'emblématique Cuba. En fait, les deux révolutions sont idéologiquement et historiquement liées, maisconnaîtront des heurs divers. Certes, il est vrai qu'à l'instar de Cuba, la Grenade – en espagnol, laGranada – possède un passé colonial indélébile, qui a lourdement impacté sur la conscience politique etesthétique de son peuple, mais l'histoire retiendra surtout de la Grenade le souvenir d'une révolutionavortée. A plus d'un titre, l'intériorisation de ce trauma, et la résilience qui en découle, représentent descomposantes essentielles du legs historique participant à la formation de l'identité culturelle caribéenne.De fait, celle-ci s'est exprimée au cours des quatre dernières décennies, sous des modes divers, par lebiais des arts et de la littérature, suivant une logique d'extériorisation et d'esthétisation de la blèsoriginelle. Comment donc passer sous silence – autrement dit, censurer, – la violence, et la gravité del'épisode d'occupation militaire américaine, qui se solda en 1983 par l'assassinat du premier ministregrenadien Maurice Bishop, au profit d'enjeux géopolitiques dits « supérieurs » ? Chassez le refoulé, ilreviendra toujours au galop. Telle est la leçon retenue par les artistes-historiens grenadiens qui se sontpenchés sur la question, et dont nous tâcherons d'élucider la portée du travail, aussi bien sur planplastique, esthétique que politique.
https://hal.archives-ouvertes.fr/hal-01664579

Droits : http://creativecommons.org/licenses/by/
hal-01664579
https://hal.archives-ouvertes.fr/hal-01664579
https://hal.archives-ouvertes.fr/hal-01664579/document
https://hal.archives-ouvertes.fr/hal-01664579/file/D%C3%A9-peindre%20la%20r%C3%A9volution%20grenadienne_traumas%2C%20censures%2C%20lib%C3%A9rations_F.%20LEFRANCOIS.pdf

Éditeur(s) : HAL CCSD
Résumé : Corsica is located in the Mediterranean sea, about 90 km from the Italian coast of Tuscany and 175 km from the French Riviera. This relatively large island stretches for 180 km in the north-south direction and 85 Km east-west. The rugged landscape, with a mean elevation of ca. 500 m and the highest point at 2710 m (Monte Cinto) is interrupted only by a major plain along the east coast. CorseAlp 2011 was held in April 2011. A link to the website is here: CorseAlp 2011. The CorseAlp field trips were designed to introduce the participants to the general features of the geology of Alpine Corsica and to recent specific discoveries. Field trip 1 focused on the geology of the Ocean-Continent Transition preserved in the Monte San Petrone, in Central Corsica, which was subducted to eclogite facies conditions during the Alpine orogeny. The three days post-workshop field trip (Field trip 2) focused on the general architecture of Alpine Corsica in an EW transect between the Balagne region and Bastia. The main topics of Field trip 1 and 2 allow discussion about the overall evolution of Alpine Corsica in the framework of Mediterranean geodynamics, with a focus on the most controversial aspects.
Journal of the Virtual Explorer

hal-00688965
https://hal.archives-ouvertes.fr/hal-00688965

Éditeur(s) : HAL CCSD Montpellier : CIRAD
Résumé : Les aménagements futurs nécessaires au développement rapide de la Guyane vont entraîner la conversion de terres forestières, participant ainsi au changement global. Les décideurs guyanais devront conjuguer ces aménagements avec la préservation des services écosystémiques forestiers. Le projet GuyaSim avait comme objectif l’approfondissement des connaissances sur ces services (stock de carbone, biodiversité et qualité du sol)et le transfert d’un logiciel aux décideurs pour faciliter l’intégration de ces connaissances dans les politiques d’aménagement du territoire. L’article présente les caractéristiques et les fonctionnalités de ce logiciel GuyaSim. Il s’agit d’un logiciel libre de type Sig, destiné a priori aux services d’aménagement des collectivités et du domaine forestier de Guyane. Le logiciel offre deux grands types de fonctionnalité : la mise à disposition d’informationset l’aide à l’aménagement. Les informations mises à disposition sont les scénarios de développement socio-économique, les scénarios climatiques et les valeurs des services écosystémiques. L’aide à l’aménagement consiste en des outils de construction des scénarios d’aménagement du territoire (changement d’usage des terres) et d’aménagement forestier (exploitation forestière), fournissant des informations sur l’impact environnemental. Les fonctionnalités du logiciel sont limitées par les connaissances sur les écosystèmes guyanais. Les avancées des projets de recherche en cours permettront de mettre à jour le logiciel à moyen terme
ISSN: 0006-579X

hal-01535354
https://hal.archives-ouvertes.fr/hal-01535354
PRODINRA : 351684

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : Ten international laboratories participated in an inter-laboratory comparison of a fossil bone composite with the objective of producing a matrix and structure-matched reference material for studies of the bio-mineralization of ancient fossil bone. We report the major and trace element compositions of the fossil bone composite, using in-situ method as well as various wet chemical digestion techniques. For major element concentrations, the intra-laboratory analytical precision (%RSDr) ranges from 7 to 18%, with higher percentages for Ti and K. The %RSDr are smaller than the inter-laboratory analytical precision (%RSDR; <15-30%). Trace element concentrations vary by similar to 5 orders of magnitude (0.1 mg kg(-1) for Th to 10,000 mg kg(-1) for Ba). The intra-laboratory analytical precision %RSDr varies between 8 and 45%. The reproducibility values (%RSDR) range from 13 to <50%, although extreme value >100% was found for the high field strength elements (Hf, Th, Zr, Nb). The rare earth element (REE) concentrations, which vary over 3 orders of magnitude, have %RSDr and %RSDR values at 8-15% and 20-32%, respectively. However, the REE patterns (which are very important for paleo-environmental, taphonomic and paleo-oceanographic analyses) are much more consistent. These data suggest that the complex and unpredictable nature of the mineralogical and chemical composition of fossil bone makes it difficult to set-up and calibrate analytical instruments using conventional standards, and may result in non-spectral matrix effects. We propose an analytical protocol that can be employed in future inter-laboratory studies to produce a certified fossil bone geochemical standard. (C) 2007 Elsevier B.V. All rights reserved.
ISSN: 0003-2670

hal-00407629
https://hal.archives-ouvertes.fr/hal-00407629
DOI : 10.1016/j.aca.2007.08.015

Résumé : The use of acoustical systems in various human activities in the ocean (industry, defence, science) raises the issue of their impact upon marine mammals populations. Several serious accidents linked to the use of naval sonars led the military, industrial and scientific communities to investigate the potential dangers of their own activity. This report aims at identifying the risks for the cetaceans linked to the use of acoustic and seismic systems currently used for oceanographic science. The analysis proposed here stays within the frame of bibliography synthesis and elementary modelling, and brings no new scientific elements on the topic. An overview of the status of cetacean populations is given first, with a summary of the possible acoustical threats. Risks are classified and described, insisting on the cases of massive stranding events. The present status of knowledge about auditory characteristics of cetaceans is summarised, and the definition of an objective threshold for acoustical risk is discussed ; the usually-admitted values are finally retained, despite of their evident limitations. The report presents also the emission characteristics of the various acoustic and seismic systems used in oceanographic, emphasising the ones operated by Ifremer; for the potentially harmful ones (according to the currently-used criteria) a model is proposed for the radiated acoustical intensity field, giving the extent of risk areas. This analysis concludes to the harmlessness of most systems, excepted heavy seismics and at a lesser degree low-frequency multibeam echosounders. Finally a variety of possible mitigation measures are presented and discussed; the regulations imposed by some countries are detailed. The report finally recommends both short-term measures aimed at limiting the potential risks, and longer-term actions for participating in the general effort of scientific and technological research in this field.
L'emploi des systèmes acoustiques dans les diverses activités humaines en milieu océanique (industrielles, de défense, scientifiques) pose le problème de leur impact sur les populations de mammifères marins. L'évidence de plusieurs événements graves liés à l'utilisation de sonars navals a amené les communautés militaires, industrielles et scientifiques à s'interroger sur les dangers potentiels de leurs propres activités. Le présent rapport tente de cerner les risques, pour les Cétacés, liés à l'emploi des systèmes acoustiques et sismiques couramment mis en oeuvre pour la recherche océanographique. L'analyse proposée ici reste à un niveau de synthèse bibliographique et de modélisation élémentaire, et n'offre pas d'éléments scientifiques nouveaux sur la question. On commence par donner un panorama de la situation des populations de cétacés et des agressions sonores qui les menacent. Les risques acoustiques sont répertoriés et décrits, en insistant sur les cas avérés d'échouages massifs. L'état actuel de connaissances sur les caractéristiques auditives des cétacés est résumé, et la définition d'un seuil objectif de risque acoustique est discutée ; on retient par défaut les valeurs de seuils généralement admises actuellement, en dépit de leurs limitations évidentes.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2007/rapport-2390.pdf
http://archimer.ifremer.fr/doc/00000/2390/

Éditeur(s) : HAL CCSD BioScientifica
Résumé : International audience
BACKGROUND: Differences in circulating steroid hormone levels have been hypothesized to explain ethnic differences in steroid-related diseases. The aim of this study was to determine the serum levels of a wide panel of steroid hormones, both androgens and estrogens, in healthy middle-aged African-Caribbean and European men. DESIGN AND METHODS: Serum steroid hormone levels were determined in men participating in a systematic public health study funded by the French National Health Insurance system. Blood was collected in the morning from 304 healthy African-Caribbean and European men aged between 40 and 69 years. Serum steroids were measured by mass spectrometry-gas chromatography, except for DHEAS and sex hormone-binding globulin, which were determined by RIA. Data were analyzed in 10-year age intervals by analysis of covariance, with adjustment for age, body mass index, waist-to-hip ratio, tobacco and alcohol consumption, and season of sampling. RESULTS: Compared with Europeans, African-Caribbean men presented significantly higher serum levels of measured bioavailable testosterone, 4-androstenedione (4-dione), and estrone (E1) regardless of the age group, of 5-androstenediol (5-diol) in those aged 40-49 and 50-59 years, and of testosterone (TT) and dihydrotestosterone in those aged 40-49 years. In contrast, European men aged 40-69 years showed significantly higher serum levels of DHEA and DHEAS. CONCLUSIONS: Significant differences in serum steroid hormone levels were observed in middle-aged African-Caribbean and European men. Whether such differences could contribute to ethnic differences in disease risk in adult men remains to be investigated. Some steroids, such as bioavailable TT, 4-dione, 5-diol, and E1, deserve particular attention.
ISSN: 0804-4643

hal-00876034
https://hal.archives-ouvertes.fr/hal-00876034
DOI : 10.1530/EJE-11-0551
PUBMED : 21951700

Éditeur(s) : HAL CCSD Federación Española de Asociaciones de Docentes de Educación Física (FEADEF)
Résumé : International audience
The scientific literature about AIDS and physical exercise has been traditionally dominated by biomedical approaches. The first studies which were published in the beginning of the nineties focused mainly on the transmission risks of the virus during sports. Later studies were concerned with the physiological logics of the exercise on HIV-positive persons. Since the end of the nineties the therapeutic progress contributed to envisage sport as a way to mediate the side effects of medical treatments. However the present review highlights a serious gap in the literature on Sport and HIV using a sociological point of view. The authors of this article argue that the time has come to consider sociological data linked to the experiences of HIV/AIDS in order to understand the difficulties and barriers that seropositive persons have to face when participating in sport.
ISSN: 1579-1726

hal-01681888
https://hal.archives-ouvertes.fr/hal-01681888

Éditeur(s) : HAL CCSD Thieme Publishing
Résumé : International audience
We evaluated the eff ects of the fl uid replacement strategy on core temperature, heart rate and urine osmolality during a 27-km trail run in tropical climate. 20 well-trained runners completed a 27-km trail race in tropical conditions. They were acclimatized to these conditions. Heart rate was monitored every 5 s, while core temperature and perceived thermal and comfort sensations were recorded before, at the 11 th km, and just after the end of the race. Water intake, urine osmolality and body mass were measured before and after the race. Core temperature and the scores of perceived thermal and comfort sensations were signifi cantly higher at the 11 th km and at the end of the race compared to before the race, but not at the 11 th km compared to before the race. No participant exhibited dehydration as assessed by urine osmolality. The less the trail runners weighed, the greater the heat retention was. The less hot they felt at the end of the race, the more they lost water, and the better the performance was. The fastest runners were able to tolerate a greater variation in core temperature between the beginning and the end of the trail race with lower water intake.
ISSN: 0172-4622

hal-01152345
https://hal.univ-antilles.fr/hal-01152345
DOI : 10.1055/s-0033-1349108

Éditeur(s) : HAL CCSD
Résumé : The mosquito species Aedes (Stegomyia) aegypti (Linnaeus 1762) was introduced into the Americas some 400 years ago from the African continent. Currently, this species is the primary agent behind dengue and chikungunya outbreaks in the pan-tropical area and its widespread distribution has likely played an important role in the recent expansion of the Zika virus. The biology of Ae. (Stg.) aegypti is particularly well known, which is not the case for its ecology. By adopting a cross-disciplinary approach I attempted to understand the relative contribution of biotic and abiotic factors as well as some evolutionary processes in the distribution of this species at the local and regional scales in French Guiana.Initially, I was interested in revising the core knowledge concerning the diversity of mosquitoes in French Guiana. By combining traditional and molecular taxonomy, this step allowed my colleagues and I to discover several new species and to create the appropriate tools to manage this type of entomological data.Secondly, we studied the spatio-temporal structure of resident aquatic macroinvertebrate communities in urban areas. This highlighted the existence of antagonistic and mutualistic interactions. In particular, the native mosquito Limatus durhamii Theobald 1901 appears to prevent the sustainable establishment of Ae. (Stg.) aegypti in slightly urbanized environments via a mechanism of competitive exclusion.
Le moustique Aedes (Stegomyia) aegypti (Linnaeus 1762) a été introduit dans les Amériques depuis le continent africain il y a environ 400 ans. Actuellement, cette espèce est la principale responsable des épidémies de dengue et de chikungunya dans la zone pantropicale et sa large répartition a très probablement joué un rôle important dans l’expansion récente du virus Zika. La biologie d’Ae. (Stg.) aegypti est particulièrement bien connue, ce qui n’est pas le cas de son écologie, en particulier de ses interactions avec les communautés résidentes. En adoptant une démarche pluridisciplinaire je me suis intéressé à la contribution relative des facteurs biotiques et abiotiques ainsi que de certains processus évolutifs dans la distribution de cette espèce à différentes échelles en Guyane française.Dans un premier temps j’ai participé à la révision des connaissances fondamentales sur la diversité des moustiques de Guyane. En alliant la taxonomie classique et moléculaire, cette étape a permis de découvrir plusieurs nouvelles espèces et de mettre en place des outils adaptés à la gestion de ce type de données, notamment pour une utilisation future.Dans un second temps la structuration spatio-temporelle des communautés résidentes de macro-invertébrés aquatiques a été étudiée en milieu urbain. Cela a permis de mettre en évidence l’existence d’interactions antagonistes et mutualistes avec les taxons des communautés résidentes. En particulier, le moustique autochtone Limatus durhamii Theobald 1901 semble empêcher l’établissement durable d’Ae. (Stg.) aegypti dans les milieux faiblement urbanisés via un mécanisme d’exclusion compétitive.
https://tel.archives-ouvertes.fr/tel-01405425

NNT : 2016YANE0001
tel-01405425
https://tel.archives-ouvertes.fr/tel-01405425
https://tel.archives-ouvertes.fr/tel-01405425/document
https://tel.archives-ouvertes.fr/tel-01405425/file/These_Def_Talaga.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Serpentinites are one of the major components of the oceanic lithosphere and are stable in the slab and the mantle wedge up to 100-150 km depth in subduction zones. During oceanic mantle hydration and alteration, they trap trace and fluid mobile (FME: B, Li, As, Sb, Rb, Ba, Cs, Sr, U and Pb) elements that participate to elemental transfer occurring between the dehydrating slab and the mantle wedge in subduction context. The Lanzo massif is an eclogitized oceanic lithosphere that preserved its oceanic structure and recorded different steps of serpentinization/de-serpentinization from oceanic lizardite to prograde antigorite in subduction context, up to its dehydration and secondary olivine crystallization, and finally retrograde antigorite during massif exhumation. It constitutes a suitable place to study trace element behavior during serpentinization/de-serpentinization processes and associated chemical transfers between the different envelopes of the oceanic lithosphere and the mantle wedge. Geochemical analyses of serpentine and associated minerals show that the serpentinization/de-serpentinization of the Lanzo massif took place in a relatively closed system without significant trace element transfer between the different parts of the oceanic lithosphere. In the deeper part of the lithosphere, from the slightly serpentinized mantle peridotites (SSP, < 20% serpentinization) to the paleo-Moho, composed of massive serpentinites (MS, 80% serpentinization), the trace elements mobility is reduced. The chemical composition of lizardite and antigorite is homogenized with the local degree of serpentinization: in SSP, serpentine veins composition is inherited from the host mineral while, in MS, their composition is homogenous between destabilized phases at the scale of the outcrop (~ 5 m). In the shallowest part of the oceanic lithosphere, from the paleo-Moho to the oceanic paleo-seafloor, the serpentinites are foliated (FS, > 90% serpentinization). In that zone, the alpine deformation enhances the mobility of trace elements and permits their redistribution and the homogenization of antigorite composition at massif scale. Locally, in the SSP and MS, the crystallization of metamorphic veins of ~ 1-2 m corresponds to channelized fluid flows that allowed fluid transfers - and thereby trace elements - to longer distance. The successive crystallizations of antigorite and then olivine are accompanied by a diminution of some FME (B, Li, As, Sb, Ba, Rb) and Eu contents attesting that these elements are removed from slab to mantle wedge during subduction.
ISSN: 0009-2541

hal-00937661
https://hal.archives-ouvertes.fr/hal-00937661
DOI : 10.1016/j.chemgeo.2013.08.025

Éditeur(s) : HAL CCSD
Résumé : The spectrin-based skeleton is an essential scaffold underlying different lipid bilayers in all animal cells. Spectrins (Sp), as giant extended flexible heterotetramers (αβ)2, constitute the filaments of this network, the nodes of which are cross-linked by actin filaments. The functions of the Sp-based skeleton, which are well defined in red blood cells (required for shape, resistance to shear stress and deformability) are less well understood in non-erythroid cells.The non-erythroid Sp might participate in the establishment and/or the maintenance of specialized membrane subdomains by accumulating integral membrane proteins (such as ionic channels, ionic pumps, receptors and cell adhesion molecules) as revealed by loss of the main non-erythroid β-Sp. However the effect of non-erythroid α-Sp are less well established. In mammals, α-Sp are encoded by two genes: one for αI-Sp mainly expressed in mature erythrocyte, the second one for αII-Sp which is expressed in all nucleated cells.In the pursuit of αII-Sp functions, we have checked the effect of αII-Sp knock down by siRNA melanoma human cell line. Our data revealed that spectrin depletion is associated with i) an arrest of cell cycle at G1 state ii) a loss of cell adhesion in spite of increase in some integrins iii) some modifications of actin organisation.
Le squelette dépendant de la spectrine, localisé sous la bicouche lipidique, est un échafaudage essentiel de toutes les cellules animales. La Spectrine (Sp), structure géante, robuste mais flexible d'hétéro tétramères (αβ)2, constitue les filaments de ce réseau, dont chaque nœud interagit avec des filaments d'actine. Les fonctions du squelette de Sp, qui sont bien définies dans le globule rouge (rôle dans sa forme, dans sa résistance aux forces de cisaillement et dans sa déformabilité) sont moins bien connues dans les cellules non-érythroïdes. La Sp non-érythroïde pourrait participer à l'établissement et/ou au maintien de sous-domaines membranaires spécialisés dans l'accumulation de protéines de membrane (telles que les canaux ioniques, les pompes ioniques, les récepteurs et les molécules d'adhérence) comme nous le font penser les invalidations de la Sp-β non-érythroïde. Cependant le rôle de la Sp-α non-érythroïde est moins bien établi. Chez les mammifères, la Sp-α est codée par deux gènes: un pour Sp-αI, principalement exprimée dans l'érythrocyte mature, le second pour Sp-αII qui est exprimée dans toutes les cellules nucléées. Pour étudier les fonctions de la Sp-αII, nous avons utilisé une approche de SiRNA sur des cellules de mélanome humain. Nos données montrent que la diminution de Sp-αII est associée à I) un arrêt en G1 du cycle cellulaire II) une perte d'adhérence des cellules malgré l'augmentation de quelques intégrines III) des modifications dans l'organisation du réseau d'actine.
https://tel.archives-ouvertes.fr/tel-00377569

Droits : info:eu-repo/semantics/OpenAccess
tel-00377569
https://tel.archives-ouvertes.fr/tel-00377569
https://tel.archives-ouvertes.fr/tel-00377569/document
https://tel.archives-ouvertes.fr/tel-00377569/file/these_210409_entiere.pdf
https://tel.archives-ouvertes.fr/tel-00377569/file/II-Spectrin_Is_Critical_for_Cell_Adhesion_and_Cell_Cycle.PDF

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
Les quarante-quatre jours de conflits, de grèves, de manifestations, et de blocages économiquesà l’initiative du collectif guadeloupéen « Liyannaj Kont Pwofitasyon » (LKP) qui ont marquéles opinions sont le reflet des crises sociales, économiques, voire politiques et identitairesCrises et conflits dans les territoires insulaires de la Caraïbe et de l’Océan Indien (20 (...) 3Études caribéennes, 17 | Décembre 2010qui secouent les Départements et Régions d’Outre-Mer mais aussi de nombreux territoiresinsulaires. En Guadeloupe, au cours de cette mobilisation d’envergure, des dizaines de milliersde manifestants organisés derrière le collectif LKP regroupant près de cinquante organisationsculturelles, politiques et syndicales, ont revendiqué une hausse du pouvoir d’achat avec pourleitmotive la lutte contre « la vie chère ». Ces crises qui impactent les territoires insulairesont souvent une cause lointaine, globale, multiforme. D’autres ont participé activement audéclenchement de cette crise mondiale, notamment certains paradis fiscaux à l’origine de lafaillite des subprimes.
ISSN: 1779-0980

hal-01203236
https://hal.archives-ouvertes.fr/hal-01203236
https://hal.archives-ouvertes.fr/hal-01203236/document
https://hal.archives-ouvertes.fr/hal-01203236/file/etudescaribeennes-5013-17-crises-et-conflits-dans-les-territoires-insulaires-de-la-caraibe-et-de-l-ocean-indien-2009-2010.pdf

Éditeur(s) : HAL CCSD
Résumé : National audience
Cette expérimentation menée en contexte didactique porte sur l’usage des SMS (Short Message Service) à l’université. Vingt-neuf étudiants ont participé, ainsi qu’une enseignante. Les étudiants pouvaient envoyer des SMS pendant le cours, soit pour communiquer entre eux ou vers l’extérieur (SMS divers), soit pour répondre à des questions posées par l’enseignante (SMS didactiques). Tous les SMS envoyés étaient mis en copie à un numéro de téléphone portable utilisé pour l’occasion visant la réception de l’ensemble des SMS. Nous avons reçu 392 SMS, dont 41% de SMS didactiques et 59% de SMS divers. Le corpus de SMS didactiques a ensuite été donné à l’enseignante pour une analyse des réponses aux questions. La discussion des résultats porte sur l’utilisation des SMS dans l’enseignement comme un moyen de sondage et d’interaction avec le public enseigné, et sur la relation entre la fréquence d’envoi de SMS et la qualité des réponses chez les étudiants.
IHM'14, 26e conférence francophone sur l'Interaction Homme-Machine
Lille, France

Droits : info:eu-repo/semantics/OpenAccess
hal-01089630
https://hal.archives-ouvertes.fr/hal-01089630
https://hal.archives-ouvertes.fr/hal-01089630/document
https://hal.archives-ouvertes.fr/hal-01089630/file/p52-anciaux.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Pyrethroid insecticides are widely used in agriculture and in homes. Despite the neurotoxicity of these insecticides at high doses, few studies have examined whether lower-level exposures could adversely affect children's neurodevelopment. The PELAGIE cohort included 3421 pregnant women from Brittany, France between 2002 and 2006. When their children reached their sixth birthday, 428 mothers from the cohort were randomly selected, successfully contacted and found eligible. A total of 287 (67%) mothers agreed to participate with their children in the neuropsychological follow-up. Two cognitive domains were assessed by the Wechsler Intelligence Scale for Children: verbal comprehension and working memory. Five pyrethroid and two organophosphate insecticide metabolites were measured in maternal and child first-void urine samples collected between 6 and 19 gestational weeks and at 6 years of age, respectively. Linear regression models were used to estimate associations between cognitive scores and urinary pyrethroid metabolite concentrations, adjusting for organophosphate metabolite concentrations and potential confounders. Maternal prenatal pyrethroid metabolite concentrations were not consistently associated with any children's cognitive scores. By contrast, childhood 3-PBA and cis-DBCA concentrations were both negatively associated with verbal comprehension scores (P-trend = 0.04 and P-trend < 0.01, respectively) and with working memory scores (P-trend = 0.05 and P-trend < 0.01, respectively). No associations were observed for the three other childhood pyrethroid metabolite concentrations (4-F-3-PBA, cis-DCCA, and trans-DCCA). Low-level childhood exposures to deltamethrin (as cis-DBCA is its principal and selective metabolite), in particular, and to pyrethroid insecticides, in general (as reflected in levels of the 3-PBA metabolite) may negatively affect neurocognitive development by 6 years of age. Whatever their etiology, these cognitive deficits may be of importance educationally, because cognitive impairments in children interfere with learning and social development. Potential causes that can be prevented are of paramount public health importance
ISSN: 0160-4120

hal-01162374
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01162374
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01162374/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01162374/file/Pyrethroid%20insecticide%20exposure.pdf
DOI : 10.1016/j.envint.2015.05.009

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
The impact of stratospheric ozone on the tropospheric general circulation of theSouthern Hemisphere (SH) is examined with a set of chemistry‐climate models participatingin the Stratospheric Processes and their Role in Climate (SPARC)/Chemistry‐ClimateModel Validation project phase 2 (CCMVal‐2). Model integrations of both the past andfuture climates reveal the crucial role of stratospheric ozone in driving SH circulationchange: stronger ozone depletion in late spring generally leads to greater polewarddisplacement and intensification of the tropospheric midlatitude jet, and greater expansion ofthe SH Hadley cell in the summer. These circulation changes are systematic as polewarddisplacement of the jet is typically accompanied by intensification of the jet and expansion ofthe Hadley cell. Overall results are compared with coupled models participating in theIntergovernmental Panel on Climate Change Fourth Assessment Report (IPCC AR4), andpossible mechanisms are discussed. While the tropospheric circulation response appearsquasi‐linearly related to stratospheric ozone changes, the quantitative response to a givenforcing varies considerably from one model to another. This scatter partly results fromdifferences in model climatology. It is shown that poleward intensification of the westerly jetis generally stronger in models whose climatological jet is biased toward lower latitudes.This result is discussed in the context of quasi‐geostrophic zonal mean dynamics.
ISSN: 2169-897X

hal-00337060
https://hal.archives-ouvertes.fr/hal-00337060
https://hal.archives-ouvertes.fr/hal-00337060/document
https://hal.archives-ouvertes.fr/hal-00337060/file/Bock_et_al-2008-Journalsur Geophysical_Research__Solid_Earth_%281978-2012%29.pdf
DOI : 10.1029/2008JD010327

Éditeur(s) : HAL CCSD L'Harmattan
Résumé : International audience
Lorsqu'on saisit le rôle de la communication dans le développement des sociétés contemporaines, on observe deux tendances complémentaires : la globalisation et la localisation. L'une modifie les circuits d'information, standardise les pratiques de communication par l'usage de dispositifs techniques et les échanges marchands ; l'autre encourage des pratiques communicationnelles dans l'environnement de proximité pour en assurer l'insertion dans l'économie globale. On ne peut donc s'en tenir à l'idée séduisante que le monde est devenu un « village global », et que le développement des techniques de communication entraîne une « déterritorialisation » des activités humaines. Certes, la communication participe activement à la recomposition des territoires qui se manifeste par un renforcement de l'autonomie du local (Miège, 1997). Cependant, ni la valorisation des identités (dans les espaces politiques nationaux, régionaux, locaux) intégrée par la dimension de standardisation technique, ni l'organisation sociale des territoires (fondée sur les identités) prise en compte par la dimension de produits culturels n'ont à voir avec la revendication identitaire qui encourage les communautarismes. D'où la question du rôle des identités culturelles dans les processus d'intégration dominants. Comment les alliances s'opèrent-elles entre les modèles culturels populaires et les formats industriels ?
Culture, communication, globalisation
Brazzaville - Kinshassa, Congo - Brazzaville

hal-01152943
https://hal.archives-ouvertes.fr/hal-01152943
https://hal.archives-ouvertes.fr/hal-01152943/document
https://hal.archives-ouvertes.fr/hal-01152943/file/Le_Bele_en_Martinique__defense_du_patrimoine_et_promotion_de_produits_culturels.pdf

Éditeur(s) : HAL CCSD SAGE Publications
Résumé : International audience
This article examines the social uses of the body by the French of Tamil origin in the sports centres of Pondicherry (southern India). It reviews the ways in which the body participates in the development and expression of gender arrangements in a postcolonial context faced with globalization. An analysis of semi-structured interviews shows the extent to which the structure of gender relationships, although occurring in a specific community, is both affected by the logic of identity related to cultural affiliations and linked by more global imperatives to the symbolic relationships between the local area and the former motherland, Metropolitan France. Finally, it appears that far from stigmatizing evident gender positions, the organization of roles between the sexes follows a sociocultural rationale that leads couples to adopt strategies which accentuate the structure of gender. On returning to the country of origin, the play of gender opposition and complementarity thus enables the symbolic gender advantages achieved through emigration to be retained while at the same time avoiding the risk of social exclusion.
ISSN: 0011-3921

hal-01681884
https://hal.archives-ouvertes.fr/hal-01681884
DOI : 10.1177/0011392111400784