Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This work focuses on the analysis of a unique set of seismological data recorded by two temporary networks of seismometers deployed onshore and offshore in the Central Lesser Antilles Island Arc from Martinique to Guadeloupe islands. During the whole recording period, extending from January to the end of August 2007, more than 1300 local seismic events were detected in this area. A subset of 769 earthquakes was located precisely by using HypoEllipse. We also computed focal mechanisms using P-wave polarities of the best azimuthally constrained earthquakes. We detected earthquakes beneath the Caribbean forearc and in the Atlantic oceanic plate as well. At depth seismicity delineates the Wadati-Benioff Zone down to 170 km depth. The main seismic activity is concentrated in the lower crust and in the mantle wedge, close to the island arc beneath an inner forearc domain in comparison to an outer forearc domain where little seismicity is observed. We propose that the difference of the seismicity beneath the inner and the outer forearc is related to a difference of crustal structure between the inner forearc interpreted as a dense, thick and rigid crustal block and the lighter and more flexible outer forearc. Seismicity is enhanced beneath the inner forearc because it likely increases the vertical stress applied to the subducting plate.
ISSN: 0040-1951

hal-01052679
https://hal.archives-ouvertes.fr/hal-01052679
DOI : 10.1016/j.tecto.2011.08.006

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In the South Tien Shan range (Kyrgyzstan), the Late Paleozoic geodynamic evolution remains debated especially to the west of the Talas-Fergana fault (TFF) fault where suture-related high-pressure (HP) rocks are scarce. We provide new petrological and geochronological data on garnet amphibolites from the Chatkal range, to the west of the TFF, northwest of the South Tien Shan suture. These rocks are retrogressed eclogites. We used a micro-mapping approach combined with forward modeling and empirical thermobarometry to decipher the P–T path of these amphibolitized eclogites. The metamorphic peak conditions culminated at 490 ± 50 °C and 18.5 ± 2 kbar and were followed by higher temperature retrogression (∼560 °C at 11–7 kbar). In order to constrain the age of the HP stage, we dated allanite crystals texturally coeval to the HP mineral assemblage. Allanite grains dated in situ with a U–Pb LA-ICPMS methodology yield an age of 301 ± 15 Ma. Compared with previously published data for the east of the TFF, these P–T constraints allow improving the understanding of the Late Paleozoic geodynamic evolution of the South Tien Shan. To the east of TFF, the Turkestan Ocean closed around 320 Ma with the collision of the Tarim Craton with the Kazakh microcontinent. To the west of TFF, the Turkestan Ocean closed around 300 Ma, when the Alai block collided with the Kazakh microcontinent. This later collision involved nappe-stacking and intense subvertical folding in the western South Tien Shan. This complex folding explains the S-shape of the suture to the west of the TFF that cannot be observed in the eastern part. These new data allow us to propose a distinct tectonic evolution of the two sides of the TFF, which suggests that this fault was a major transform fault before being a strike-slip intra-continental fault.
ISSN: 0264-3707

hal-01347171
https://hal.archives-ouvertes.fr/hal-01347171
DOI : 10.1016/j.jog.2015.06.005

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Benzo[a]pyrene (B[a]P), the prototype molecule of polycyclic aromatic hydrocarbons, exhibits genotoxic and carcinogenic effects, which has led the International Agency for Research on Cancer to recognize it as a human carcinogen. Besides the well-known apoptotic signals triggered by B[a]P, survival signals have also been suggested to occur, both signals likely involved in cancer promotion. Our previous work showed that B[a]P induced an hyperpolarization of mitochondrial membrane potential (ΔΨm) in rat hepatic epithelial F258 cells. Elevated ΔΨm plays a role in tumor development and progression, and nitric oxide (NO) has been suggested to be responsible for increases in ΔΨm. The present study therefore aimed at evaluating the impact of B[a]P on NO level in F258 cells, and at testing the putative role for NO as a survival signal, notably in link with ΔΨm. Our data demonstrated that B[a]P exposure resulted in an NO production which was dependent upon the activation of the inducible NO synthase. This enzyme activation involved AhR and possibly p53 activation. Preventing NO production not only increased B[a]P-induced cell death but also blocked mitochondrial hyperpolarization. This therefore points to a role for NO as a survival signal upon B[a]P exposure, possibly targeting ΔΨm
ISSN: 0887-2333

hal-01163757
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163757
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163757/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163757/file/Benzo%5Ba%5Dpyrene-induced%20nitric.pdf
DOI : 10.1016/j.tiv.2015.06.010

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : International audience
New geodynamical data from West Africa bring consistent informations on the pre-Mesozoic reconstruction within a large area running from the western Sahara to the Colombian cordillera. These new data support a Neoproterozoic Ocean (WANO) between the Amazonian (AMC) and West African (WAC) cratons previously to the Iapetus and Rheic oceans. We delineate 31 blocs detached from the surrounding three continents: NAC (North American Craton), AMC and WAC. 7 came from the WAC margin, 7 from the NAC, 6 from the AMC and 11 from an intermediate volcano sedimentary domain (COB) built on a 1200-1000 Ma oceanic crust. These imbricated blocks formed a tight mosaic by the Hercynian/Alleghanian tectonic event which gave way to the Pangea super-continent. But, during the Atlantic Ocean opening these blocks began to move. They were separated by new oceanic basins. However, previously to the Pangea, blocks from the COB domain formed two sets of garlands located on the northwestern Gondwana margin. The northern one moved to the North until the Silurian to collide the NAC (Taconic tectonic event) meanwhile the southern one remains on the Gondwana margin. All together were gathered by the Carboniferous/Permian time. Then, the framework for the opening of the Atlantic Ocean was not totally disconnected from the "Variscan" collage and many variscan weakness zones were re-used as initial breaking zones. Beyond this tectonic impact, the pre-mesozoic assemblage allows us to compare this "Caribbean" island arc with another one: the Indonesian "Banda" arc. Thus, West Africa is a geological key area for correlations between the Caribbean, the Appalachian, the Brazilian "Nordeste" and the West European domains and for the understanding of the Atlantic Ocean opening process.
EISSN: 1777-5817

hal-00842747
https://hal.archives-ouvertes.fr/hal-00842747
DOI : 10.2113/gssgfbull.184.1-2.5

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Sexually transmitted viruses infect the genital and colorectal mucosa of the partner exposed to contaminated genital secretions through a wide range of mechanisms, dictated in part by the organization of the mucosa. Because understanding the modes of entry into the organism of viruses transmitted through sexual intercourse is a necessary prerequisite to the design of treatments to block those infections, in vitro modeling of the transmission is essential. The aim of this review is to present the models and methodologies available for the in vitro study of the interactions between viruses and mucosal tissue and for the preclinical evaluation of antiviral compounds, and to point out their advantages and limitations according to the question being studied.
ISSN: 0042-6822

Droits : http://creativecommons.org/licenses/by/
hal-01663650
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01663650
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01663650/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01663650/file/Frouard%20-%20In%20vitro%20models%20for%20deciphering.pdf
DOI : 10.1016/j.virol.2017.11.023

Éditeur(s) : HAL CCSD
Résumé : Pregnancy is a sensitive and critical period for the development of the child and the health of adults-to-be. The biological and physiological adaptation of the body dealing physical and psychosocial stressors during this period may exert its effects in adulthood (and possibly over several generations). This delayed toxicity presupposes intrinsically the need to study the effects of exposure to environmental risk factors during fetal life using a holistic approach involving risk factors at both the micro (individual characteristics) and the macro level (physical and psycho-social context). Given the heterogeneity of the Breton territory in which this work was conducted, we explored whether the impact of social inequalities and the physical environment (air pollution) on birth outcomes (fetal growth and the risk of prematurity) could be modified according to an urban or rural place of residence. This work was based on data collected as part of the Breton mother-child cohort PELAGIE, which had included 3421 pregnant women between 2002- 2006. The anthropometric parameters and gestational age at birth were measured by medical personnel at delivery. We defined urban and rural areas according to the definition of “urban units” from the National Census Bureau (INSEE). The annual concentrations of air pollution (nitrogen dioxide (NO2)) were estimated using a land-use regression modeled at a 100 m scale and developed as part of an European project. Finally, neighbourhood deprivation was estimated using a composite index developed at census blocks level and whose use was legitimated over both urban and rural areas. Neighbourhood deprivation was associated with an increased risk of infants with fetal growth restriction, only for women living in rural areas. We also observed an increased risk of preterm birth associated with NO2 concentrations > 16.4 μg.m-3, only among women residing in urban areas. The associations between air pollution and fetal growth, although sex-specific, did not seem on the other hand, to vary significantly according to the urban-rural spectrum. This work confirms the need to explore the influence of both social and environmental inequalities on intrauterine development, and to assess the role of place-based factors, such as the urban-rural context, in shaping these inequalities.
La grossesse est une période sensible et déterminante pour le développement de l’enfant et l’état de santé à l’âge adulte. L'adaptation biologique et physiologique de l'organisme face à des « stresseurs » physiques et psychosociaux au cours de cette période peut ainsi exercer ses effets à l'âge adulte (et possiblement sur plusieurs générations). Cette toxicité différée suppose intrinsèquement la nécessité d’étudier les conséquences des expositions environnementales au cours de la vie foetale et ce suivant une approche holistique intégrant autant les facteurs de risque à des niveaux micro (caractéristiques individuelles) et macro (expositions physiques externes et contexte psycho-social). Etant donné l’hétérogénéité du territoire breton dans lequel s’inscrit ce travail de thèse, nous avons cherché à explorer l’impact des inégalités sociales et de l’environnement physique (pollution atmosphérique) sur l’issue de la grossesse (croissance foetale et risque de prématurité) indépendamment chez des femmes enceintes résidant dans des zones urbaines et rurales. Ce travail s’est appuyé sur les données issues de la cohorte bretonne mère-enfant PELAGIE, qui a inclus 3421 femmes enceintes entre 2002- 2006. Les paramètres anthropométriques et l’âge gestationnel à la naissance ont été renseignés à l’accouchement par le personnel médical. Le contexte urbain et rural breton a été caractérisé à partir de la définition des unités urbaines de l’INSEE. Les concentrations annuelles de pollution atmosphérique (dioxyde d’azote (NO2)) ont été modélisées à une échelle de 100 m à partir d’un modèle de "land-use regression" développé à l’échelle européenne. Enfin, le niveau socio-économique des IRIS a été estimé à l’aide d’un indice de désavantage social - construit à partir des données du recensement de l’INSEE et dont la validité et l’adaptabilité à des territoires à la fois urbains et ruraux a été examinée au préalable. Nos résultats suggèrent une influence délétère d’un contexte de vie socioéconomique défavorable sur la croissance intra-utérine, spécifiquement chez les femmes résidant en milieu rural. Nous avons également observé une augmentation du risque de prématurité associée à des niveaux > 16.4 μg.m-3 de NO2 dans l’air, à l’inverse, uniquement chez les femmes résidant dans des zones urbaines. Les associations entre l’exposition à la pollution atmosphérique et les marqueurs de la croissance intra-utérine, bien que sexe-spécifiques, ne semblent en revanche pas varier sensiblement suivant le gradient urbain-rural. Ce travail confirme la nécessité d’évaluer l’influence des inégalités sociales et environnementales sur le développement intra-utérin et de considérer l’importance et le rôle du contexte de vie, notamment urbain-rural, dans la formation de ces inégalités.
https://tel.archives-ouvertes.fr/tel-01308518

NNT : 2015REN1B010
tel-01308518
https://tel.archives-ouvertes.fr/tel-01308518
https://tel.archives-ouvertes.fr/tel-01308518/document
https://tel.archives-ouvertes.fr/tel-01308518/file/BERTIN_M--lanie.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Major and trace element signatures and Sr-Nd-Pb isotope data for muscovite (Ms)-bearing amphibolite blocks and associated muscovite-bearing trondhjemite and quartz-muscovite rocks from the Sierra del Convento melange (eastern Cuba) indicate that Proto-Caribbean oceanic crust underwent wet partial melting processes during Mesozoic subduction and after accretion to the upper plate. Trace element normalized patterns of Ms-bearing amphibolites are enriched in light rare earth elements (LREE) and large-ion lithophile elements (LILE) and evidence variable trace element transfer from the Proto-Caribbean subducting slab to the mantle wedge. Ms-bearing trondhjemites show LREE enrichment and HREE depletion and have geochemical features similar to adakites, including SiO2>56 wt.%, high Na2O contents (5.5-9.0 wt.%) and high Sr/Y (16-644). We consider that the trondhjemites represent primary and natural melts formed by deep partial melting of the subducting slab which did not significantly react with the mantle wedge before intrusion in the subduction channel. The Ms-bearing trondhjemites show different geochemical and petrological signatures compared with the Ms-free tonalites-trondhjemites from Sierra del Convent, that are interpreted as primary slab melts. These differences support the idea that partial melting processes in the Sierra del Convento subduction channel were triggered by the infiltration of fluids derived from three distinct subducted sources: sediments, altered mid-ocean ridge basalts (MORB), and serpentinites. In this scenario, the pegmatitic quartz-muscovite rocks, which are highly enriched in LILE, probably represent the crystallization products of fluids derived by differentiation of the trondhjemitic melts.
ISSN: 0024-4937

hal-00669881
https://hal.archives-ouvertes.fr/hal-00669881
DOI : 10.1016/j.lithos.2011.07.011

Éditeur(s) : Elsevier Science Bv
Résumé : The rollback of a segmented slab of oceanic lithosphere is typically accompanied by vertical lithospheric tear fault(s) along the lateral slab edge(s) and by strike slip movement in the upper plate, defined as a STEP fault (Subduction Tear Edge Propagator). The Neogene evolution of the Central Mediterranean is dominated by the interaction between the slow Africa–Eurasia convergence and the SE-ward rollback of the Ionian slab, that leads to the back-arc opening of the Tyrrhenian Sea. Here, we present post-stack time migrated and pre-stack depth migrated Archimede (1997) multichannel seismic lines, that were acquired offshore eastern Sicily, at the foot of the Malta escarpment. First, we identify the recent deformation along the lateral ramp of the Calabrian accretionary wedge. Towards the east, the Calabrian wedge is formed by the accretion of the post-evaporitic sediments, above a decollement at the base of the Messinian evaporites. At the latitude of Syracuse, 50 km east of the Malta escarpment, a major N150°E trending crustal scale and vertical fault slices through the entire accretionary wedge. This fault cuts by several kilometers, through the pre-evaporitic Messinian sediments and into the basement. The vertical offset along this vertical fault decreases from north to south, and the fault is no longer observed on the seismic lines, 50 km SE of the Alfeo seamount. A previously published Moho depth isocontour map, offshore Sicily and the recent GPS data, combined with the presence of strike slip movements NE onshore Sicily, allow us to identify this 200 km long crustal-scale fault as the surface expression of a STEP fault. The presence of syntectonic Pleistocene sediments on top this crustal-scale fault suggests a recent lithospheric vertical movement of the STEP fault, in response to the rollback of the Ionian slab and to the SE-ward advance of the Calabria-Peloritan block
Tectonophysics (0040-1951) (Elsevier Science Bv), 2013-08 , Vol. 602 , P. 141-152

Droits : 2013 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/00118/22878/21386.pdf
DOI:10.1016/j.tecto.2012.12.026
http://archimer.ifremer.fr/doc/00118/22878/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Hengshan–Wutaishan area forms part of the Trans-North-China Belt developed in response to the final amalgamation of the North China Craton. The Hengshan–Wutaishan domain and the adjacent Fuping massif constitute the largest and the most representative rock exposure of the belt. A structural study allows us to redefine the lithological and tectonic units that compose the architecture of the Hengshan–Wutaishan domain and to propose that the Trans-North-China Belt was built up through a polyphase tectonic evolution within the period 1900–1800 Ma. The first event (D1) corresponds to the emplacement of lower and upper nappes herein called the Orthogneiss and Volcanites Unit (OVU) and the Low Grade Mafic Unit (LGMU), respectively. The OVU mainly consists of rocks formed in an arc system and metamorphosed under amphibolite facies conditions whereas the LGMU represents oceanic crust rocks with an arc component that underwent greenschist facies metamorphism. The syn-metamorphic D1 deformation is characterized by a NW–SE stretching and mineral lineation with a top-to-the SE sense of shear that corresponds to the sense of nappe motion. U–Th–Pb EPM chemical dating on monazite from three metapelites of the OVU gives isochron ages of 1884 ± 11 Ma, 1886 ± 5 Ma and 1887 ± 4 Ma interpreted as the age of the prograde amphibolite facies metamorphism coeval with nappe stacking during the D1 event. The D2 event corresponds to a widespread crustal melting of the OVU and underlying basement rocks in Hengshan related to the exhumation of deep structures about 20–30 Ma after nappe emplacement. The migmatite contains blocks of retrograded eclogite or HP-granulitic restites, and is characterized by the development of a pervasive foliation and lineation. A late D2 event represents the folding stage of the migmatitic foliation during the completion of a dome. The Orthogneiss and Volcanics Unit and the Low Grade Mafic Unit are unconformably covered by weakly metamorphosed to unmetamorphosed sediments belonging to the Hutuo Supergroup. These rocks were deformed by a ductile D3 event, characterized by a NW–SE trending stretching lineation, south verging folds associated with an axial planar slaty cleavage and an E–W crenulation lineation. Lastly, a left-lateral wrenching along the Zhujiafang Shear Zone separates the northern and southern parts of Hengshan. Our structural study shows that there is no significant difference between the southern part of Hengshan and the lower part of Wutaishan, both areas belong to OVU and show a structural continuity. We suggest that this polyphase deformation developed in response to a north-westward subduction of an old ocean, named the Lüliang Ocean, beneath the Western Block, followed by collision with a micro-continent named the Fuping Block at not, vert, similar1890–1880 Ma.
ISSN: 0301-9268

insu-00151594
https://hal-insu.archives-ouvertes.fr/insu-00151594
https://hal-insu.archives-ouvertes.fr/insu-00151594/document
https://hal-insu.archives-ouvertes.fr/insu-00151594/file/Trap-PrecambrainResearch-2007.pdf
DOI : 10.1016/j.precamres.2007.03.001

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Lateral variations along the Himalayan arc are suggested by an increasing number of studies and carry important information about the orogen’s segmentation. Here we compile the hitherto most complete land gravity dataset in the region which enables the currently highest resolution plausible analysis. To study lateral variations in collisional structure we compute arc-parallel gravity anomalies (APaGA) by subtracting the average arc-perpendicular profile from our dataset; we compute likewise for topography (APaTA). We find no direct correlation between APaGA, APaTA and background seismicity, as suggested in oceanic subduction context. In the Himalayas APaTA mainly reflect relief and erosional effects, whereas APaGA reflect the deep structure of the orogen with clear lateral boundaries. Four segments are outlined and have disparate flexural geometry: NE India, Bhutan, Nepal & India until Dehradun, and NW India. The segment boundaries in the India plate are related to inherited structures, and the boundaries of the Shillong block are highlighted by seismic activity. We find that large earthquakes of the past millennium do not propagate across the segment boundaries defined by APaGA, therefore these seem to set limits for potential rupture of megathrust earthquakes.
ISSN: 2045-2322

hal-01420404
https://hal.archives-ouvertes.fr/hal-01420404
https://hal.archives-ouvertes.fr/hal-01420404/document
https://hal.archives-ouvertes.fr/hal-01420404/file/hetenyi2016.pdf
DOI : 10.1038/srep33866

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study analyzes the active tectonics within the northwestern and southeastern extensions of the Pambak-Sevan-Syunik fault (PSSF), a major right-lateral strike-slip fault cutting through Armenia. Quantifying the deformations in terms of geometry, kinematics, slip rates and earthquake activity, using cosmogenic 3He, OSL/IRSL and radiocarbon dating techniques, reveal different behaviors between the two regions. Within the northwestern extension, in the region of Amasia, the PSSF bends to the west and splits into two main WNW–ESE trending reverse faults defining a compressional pop-up structure. We estimate an uplift rate and a shortening rate of 0.5 ± 0.1 mm/y and 1.4 ± 0.6 mm/y, respectively. This suggests that most of the ∼2 mm/y right lateral movement of the PSSF seems to be absorbed within the Amasia pop-structure. Within the southeastern extension, the PSSF shows signs of dying out within the Tsghuk Volcano region at the southernmost tip of the Syunik graben. There, the tectonic activity is characterized by a very slow NS trending normal faulting associated with a slight right-lateral movement. Slip rates analyses (i.e. vertical slip rate, EW stretching rate at 90° to the fault, and right-lateral slip rate of ∼0.2 mm/y, ∼0.1 mm/y and ∼0.05 mm/y, respectively) lead to the conclusion that the right lateral movement observed further north along the PSSF is mainly transferred within other active faults further west within the Karabagh (Hagari fault or other structures further northwestwards). Comparing our slip rates with those estimated from GPS data suggests that most of the deformation is localized and seismic, at least within the Tsghuk region. The geometrical and kinematic pattern observed within the two terminations of the PSSF suggests that the fault and its surrounding crustal blocks are presently rotating anticlockwise, as also observed within the GPS velocity field. This is consistent with the recent kinematic models proposed for the Caucasus-Kura-South Caspian region and brings a new insight into the present geodynamics of Armenia.
ISSN: 1040-6182

hal-01307342
https://hal.archives-ouvertes.fr/hal-01307342
DOI : 10.1016/j.quaint.2015.05.021

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
In the Wadi Haymiliyah of the Oman ophiolite (Haylayn block), discordant wehrlite bodies ranging in size from tens to hundreds of meters intrude the lower crust at different levels. We combined investigations on natural wehrlites from the Wadi Haymiliyah section with an experimental study on the phase relations in a wehrlitic system in order to constrain the petrogenesis of the crustal wehrlites of the Oman ophiolite. Secondary ion mass spectrometry analyses of clinopyroxenes from different wehrlite bodies imply that the clinopyroxenes were crystallized from tholeiitic, mid-ocean ridge (MORB)-type melts. The presence of primary magmatic amphiboles in some wehrlites suggests a formation under hydrous conditions. Significantly enhanced Sr-87/Sr-86 isotope ratios of separates from these amphiboles imply that the source of the corresponding magmatic fluids was either seawater or subduction zone-related. The experiments revealed that under wet conditions at relatively low temperatures, a MORB magma has the potential to produce wehrlite in the ocean crust by accumulation of early olivine and clinopyroxene. These show typically high Mg# which is a consequence of the oxidizing effect of the prevailing high aH(2)O. First plagioclases crystallizing after clinopyroxene under wet conditions are high in An content, in contrast to the corresponding dry system. Trace element compositions of clinopyroxenes of those wehrlites from the Moho transition zone are too depleted in HREE to be in equilibrium with present-day MORB, implying a genetic relation to the V2 lavas of the Oman ophiolite, which are interpreted to be the result of fluid-enhanced melting of previously depleted mantle. We present a model on the petrogenesis of the crustal wehrlites in an upper mantle wedge above an initial, shallow subduction zone at the beginning of the intraoceanic thrusting.
ISSN: 1525-2027

hal-00429373
https://hal.archives-ouvertes.fr/hal-00429373
DOI : 10.1029/2009GC002488

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
Despite convergent margins being unstable systems, most reports of huge submarine slope failure have come from oceanic volcanoes and passive margins. Swath bathymetry and seismic profiles of the northern Hikurangi subduction system, New Zealand, show a tapering 65-30 km wide by 65 km deep margin indentation, with a giant, 3150+_630 km 3, blocky, debris avalanche deposit projecting 40 km out across horizontal trench fill, and a debris flow deposit projecting over 100 km. Slide blocks are well-bedded, up to 18 km across and 1.2 km high, the largest being at the avalanche deposit's leading edge. Samples dredged from them are mainly Miocene shelf calc-mudstones similar to those outcropping around the indentation. Cores from cover beds suggest that failure occurred-170 +_40 ka, possibly synchronously with a major extension collapse in the upper indentation. However, the northern part of the indentation is much older. The steep, straight northern wall is close to the direction of plate convergence and probably formed around 2.0-0.16 Ma as a large seamount subducted, leaving in its wake a deep groove obliquely across the margin and an unstable triangle of fractured rock in the 60 ø angle between groove and oversteepened margin front. The triangle collapsed as a blocky avalanche, leaving a scalloped southern wall and probably causing a large tsunami. Tentative calculations of compacted volumes suggest that the indentation is over 600 km 3 larger than the avalanche, supporting a two-stage origin that includes subduction erosion. Since failure, convergence has carried the deposits-9 km back toward the margin, causing internal compression. The eventual subduction/accretion of the Ruatoria avalanche explains the scarcity of such features on active margins and perhaps the nature of olistostromes in fold belts.
ISSN: 2169-9275

hal-01261406
https://hal.archives-ouvertes.fr/hal-01261406
https://hal.archives-ouvertes.fr/hal-01261406/document
https://hal.archives-ouvertes.fr/hal-01261406/file/CollotJGR2001.pdf
DOI : 10.1029/2001JB900004

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : In southern Corsica, three successive Upper Burdigalian coral reef episodes (R1, R2 subdivided into R2A and R2B subunits, and R3) developed within the Cala di Labra Formation. Tabular corals dominated under high water energy and siliciclastic input conditions. The R1 reefs show the highest coral diversity with 16 species described for the first time. A coral impoverishment was recorded in the R2 and R3 reefal episodes. The reefs did not reach a climax growth stage, except the R1 ones. Analogous to North Sardinian reefs, they reflect local vanishing conditions in the Corsican-Sardinian block through Upper Burdigalian because of constant siliciclastic inputs and deepening of the Bonifacio straight.
ISSN: 1631-0713

hal-01054332
https://hal.archives-ouvertes.fr/hal-01054332
DOI : 10.1016/j.crte.2014.02.003

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Trivalent inorganic arsenic [As(III)] is an efficient anticancer agent used to treat patients suffering from acute promyelocytic leukemia. Recently, experimental studies have clearly demonstrated that this metalloid can also cure lymphoproliferative and/or pro-inflammatory syndromes in different murine models of chronic immune-mediated diseases. T helper (Th) 1 and Th17 lymphocytes play a central role in development of these diseases, in mice and humans, especially by secreting the potent pro-inflammatory cytokine interferon-γ and IL-17A, respectively. As(III) impairs basic functions of human T cells but its ability to modulate secretion of pro-inflammatory cytokines by differentiated Th lymphocytes is unknown. In the present study, we demonstrate that As(III), used at concentrations clinically achievable in plasma of patients, has no effect on the secretion of interferon-γ from Th1 cells but almost totally blocks the expression and the release of IL-17A from human Th17 lymphocytes co-stimulated for five days with anti-CD3 and anti-CD28 antibodies, in the presence of differentiating cytokines. In addition, As(III) specifically reduces mRNA levels of the retinoic-related orphan receptor (ROR)C gene which encodes RORγt, a key transcription factor controlling optimal IL-17 expression in fully differentiated Th17 cells. The metalloid also blocks initial expression of IL-17 gene induced by the co-stimulation, probably in part by impairing activation of the JNK/c-Jun pathway. In conclusion, our results demonstrate that As(III) represses expression of the major pro-inflammatory cytokine IL-17A produced by human Th17 lymphocytes, thus strengthening the idea that As(III) may be useful to treat inflammatory immune-mediated diseases in humans.
ISSN: 0041-008X

inserm-00872871
http://www.hal.inserm.fr/inserm-00872871
DOI : 10.1016/j.taap.2012.05.004
PUBMED : 22617429

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Mapping spatial distributions of disease occurrence can serve as a useful tool for identifying exposures of public health concern. Infant mortality is an important indicator of the health status of a population. Recent literature suggests that neighborhood deprivation status can modify the effect of air pollution on preterm delivery, a known risk factor for infant mortality. We investigated the effect of neighborhood social deprivation on the association between exposure to ambient air NO2 and infant mortality in the Lille and Lyon metropolitan areas, north and center of France, respectively, between 2002 and 2009. We conducted an ecological study using a neighborhood deprivation index estimated at the French census block from the 2006 census data. Infant mortality data were collected from local councils and geocoded using the address of residence. We generated maps using generalized additive models, smoothing on longitude and latitude while adjusting for covariates. We used permutation tests to examine the overall importance of location in the model and identify areas of increased and decreased risk. The average death rate was 4.2‰ and 4.6‰ live births for the Lille and Lyon metropolitan areas during the period. We found evidence of statistically significant precise clusters of elevated infant mortality for Lille and an east-west gradient of infant mortality risk for Lyon. Exposure to NO2 did not explain the spatial relationship. The Lille MA, socioeconomic deprivation index explained the spatial variation observed. These techniques provide evidence of clusters of significantly elevated infant mortality risk in relation with the neighborhood socioeconomic status. This method could be used for public policy management to determine priority areas for interventions. Moreover, taking into account the relationship between social and environmental exposure may help identify areas with cumulative inequalities.
ISSN: 0048-9697

inserm-00838330
http://www.hal.inserm.fr/inserm-00838330
DOI : 10.1016/j.scitotenv.2013.03.027
PUBMED : 23563257

Éditeur(s) : HAL CCSD
Résumé : International audience
The Duffy Antigen/Receptor for Chemokine (DARC) is a seven segment transmembrane protein. It was firstly discovered as a blood group antigen and was the first specific gene locus assigned to a specific autosome in man. It became more famous as an erythrocyte receptor for malaria parasites (Plasmodium vivax and Plasmodium knowlesi), and finally for chemokines. DARC is an unorthodox chemokine receptor as (i) it binds chemokines of both CC and CXC classes and (ii) it lacks the Asp-Arg-Tyr consensus motif in its second cytoplasmic loop hence cannot couple to G proteins and activate their signaling pathways. DARC had also been associated to cancer progression, numerous inflammatory diseases, and possibly to AIDS. In this review, we will summarize important biological data on DARC. Then we shall focus on recent development of the elaboration and analyzes of structural models of DARC. We underline the difficulty to propose pertinent structural models of transmembrane protein using comparative modeling process, and other dedicated approaches as the Protein Blocks. The chosen structural models encompass most of the biochemical data known to date. Finally, we present recent development of protein - protein docking between DARC structural models and CXCL-8 structures. We propose a hierarchal search based on separated rigid and flexible docking.
Infectious disorders drug targets

Droits : info:eu-repo/semantics/OpenAccess
inserm-00366309
http://www.hal.inserm.fr/inserm-00366309
http://www.hal.inserm.fr/inserm-00366309/document
http://www.hal.inserm.fr/inserm-00366309/file/de_Brevern_Autin_Bertrand_Colin_Etchebest.pdf
http://www.hal.inserm.fr/inserm-00366309/file/inserm-00366309_edited.pdf

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Interleukin-27 (IL-27) belongs to the IL-6/IL-12 family of cytokines, associated with different inflammatory diseases and orchestrates its biological activity via common heterodimeric receptor composed of WSX-1 (IL-27Rα) and gp130. The present study was aimed to investigate the regulation of CXCL9, CXCL10, and CXCL11 chemokines in hepatic cells (human LX-2 cell line derived from normal human stellate cells (HSC), primary human hepatocytes, HSC, and HepG2 cells) and concanavalin A (ConA)-induced liver inflammation. We demonstrated that IL-27, but not IL-6, induced/up-regulated CXCR3 ligand genes (CXCL9, CXCL10, and CXCL11; out of 26 selected genes) in a STAT1-dependent manner in hepatic cells in vitro both at transcript and protein levels. In ConA-induced T cell-mediated hepatic model, we showed that soluble IL-27/IFNγ was elevated following ConA hepatitis in association with increased CXCL9, CXCL10, and CXCL11 expression in the liver. The exogenous IL-27 administration induced CXCR3 ligands in mouse liver at 4 h with any significant effect on recruitment of CXCR3(+) immune cells in the liver. The neutralization of IL-27 during ConA hepatitis differentially modulated (transcript vs protein expression) CXCR3 ligands and IFNγ during ConA-induced hepatitis with down-regulated expression of CXCL9 and CXCL10 at transcript level. The IFNγ, complementary regulated the expression of CXCR3 ligands as their up-regulation during ConA hepatitis, was abolished in IFNγ KO mice. In summary, IL-27 up-regulated the CXCL9, CXCL10, and CXCL11 chemokine expression in hepatic cells. IL-27 regulated CXCR3 ligand expression in IFNγ-dependent manner during acute hepatitis suggesting a complementary role of IL-27 and IFNγ to moderate liver inflammation via regulation of CXCR3 ligands. KEY MESSAGE: IL-27 up-regulated CXCR3 ligand expression in human hepatic cells in vitro. IL-27 up-regulated CXCR3 ligand expression and secretion in ConA hepatitis in vivo. CXCR3 ligand expression was down-regulated by blocking IL-27 or IFNγ deficiency. IL-27 modulated liver injury by regulation of CXCR3 ligands in IFNγ-dependent manner.
ISSN: 0946-2716

hal-01214006
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01214006
DOI : 10.1007/s00109-015-1319-6
PUBMED : 26199110

Éditeur(s) : Elsevier
Résumé : We present new results from the MARADJA'03 cruise depicting the geological structures offshore central and western Algeria. Using swath bathymetry and seismic reflection data, we map and discuss the offshore limits of the Internal Zones corresponding to relics of the AIKaPeCa domain that drifted and collided the African plate during the Miocene. We identify large reverse faults and folds that reactivate part of these limits and are still active today. The morphology of the westernmost NE-SW margin suggests a former strike-slip activity accommodating a westward block translation responsible for the shift of the Internal Zones towards the Moroccan Rif.
Nous présentons les résultats récents de la campagne MARADJA'03, qui visent à mettre en évidence les structures géologiques dans le domaine marin au nord-ouest de l'Algérie. Grâce aux données de bathymétrie multifaisceau et de sismique réflexion, nous cartographions et discutons les limites en mer des Zones internes correspondant aux reliques du domaine AlKaPeCa qui a dérivé, puis est entré en collision avec la plaque africaine au Miocène. De grandes failles inverses et plis, actifs dans le champ de contrainte actuel, réactivent certaines de ces limites. La marge ouest-algérienne, orientée NE¿SW, indique la présence d'une ancienne activité en décrochement ayant accommodé la translation des Zones internes vers l'ouest.
Comptes Rendus Geoscience (1631-0713) (Elsevier), 2006 , Vol. 338 , N. 1-2 , P. 80-91

Droits : 2005 Académie des sciences Published by Elsevier SAS
http://archimer.ifremer.fr/doc/2006/publication-1211.pdf
DOI:10.1016/j.crte.2005.11.009
http://archimer.ifremer.fr/doc/00000/1211/

Éditeur(s) : HAL CCSD
Résumé : International audience
Sedimentary basins, through the sedimentary successions and the nature of the deposits, reflect the geology of thearea from which the sediments were derived and thus provide valuable record of hinterland tectonism. As the collisionbetween the South China and the Indochina blocks (i.e. the Indosinian orogeny) is still the object of a numberof controversies regarding, for instance, its timing and the polarity of the subduction, the sedimentary basins associatedwith this mountain belt are likely to provide clues to reconstruct its geodynamic evolution. However, boththe Sam Nua Basin (located to the south of the inner zones of the Indosinian orogeny and the Song Ma ophiolites)and the Song Da Basin (located to the north of the inner zones), northern Vietnam, are still lacking importantinformation regarding the depositional environments and the ages of the main formations that they contain.Using sedimentological and dating analyses (foraminifers biostratigraphy and U-Pb dating on detrital zircon), weprovide a new stratigraphic framework for these basins and propose a geodynamic evolution of the present-daynorthern Vietnam.During the Early Triassic, the Sam Nua Basin was mainly supplied by volcaniclastic sediments originating froman active volcanic activity. Geochemical investigations, combined with sedimentological and structural analyses,support an arc-related setting for this magmatism. This magmatic arc resulted from the subduction of a south dippingoceanic slab that once separated the South China from the Indochina blocks. During the Middle to the LateTriassic, the Sam Nua Basin underwent erosion that lead to the formation of a major unconformity, termed theIndosinian unconformity. This unconformity is interpreted to result from the erosion of the Indosinian mountainbelt, built after the continental collision between the South China and the Indochina blocks. Later, during the LateTriassic, the Sam Nua Basin experienced the deposition of very coarse material, emplaced under continental settingand representing the product of the erosion of the Indosinian mountain belt.To the North, the Song Da Basin is characterized by strongly diachronous deposits over a basal unconformitydeveloped at the expense of volcanic and volcaniclastic deposits related to the Emeishan Large Igneous Province.The sedimentary succession indicates a foreland setting during the Early to the Middle Triassic, which contrastswith the commonly assumed rift setting for these sediments. Thus, the Song Da Basin documents the formation ofthe Indosinian thrust belt, located immediately to the South of the basin.
European Geosciences Union General Assembly 2017
Vienne, Austria

insu-01510331
https://hal-insu.archives-ouvertes.fr/insu-01510331