Éditeur(s) : HAL CCSD
Résumé : International audience
Since long years, the archaeologists have analyzed the migrations link to the pre-Columbian settlement of the Antillean archipelago. On an other hand, the researches about the origins of the raw materials have demonstrated the importance of the inter-insular exchanges, exchanges not only of material elements but even of concepts and persons. This is those relations who permitted the development of real Antillean civilizations. Sadly, the off shore canoe, real civilizational tool, and the different aspects link to is utilization have been frequently absent of the discussion or only analyzed from a theoretical point of view by the meaning of modelization tries. The "Ioumoúlicou" project we will present now is an experimental archaeological program dedicated to the study of the pre-Columbian navigation conditions and techniques. Those works realized in a scientifically controlled frame completed by a canoe hydrostatic parameters analysis, gave us the possibility to obtain totally original data. Those data give us an opportunity to refund our vision of the relation of the pre-Columbian peoples with the archipelagic Antillean space.
Depuis plusieurs décennies, les recherches archéologiques ont mis en évidence plusieurs mouvements migratoires à l'origine du peuplement précolombien de l'archipel antillais. D'autre part, les travaux réalisés sur l'origine des matières premières ont permis de souligner l'importance des échanges inter-insulaires, des échanges de biens matériels mais aussi d'idées et de personnes. Ce sont ces relations qui ont permis le développement de véritables civilisations antillaises. Malheureusement, le canot de haute mer, véritable outil civilisationnel, et les différents aspects liés à son utilisation ont trop souvent été les grands absents du débat ou approchés uniquement d'une point de vue théorique au travers de tentatives de modélisation. Le projet "Ioumoúlicou" que nous allons vous présenter ici correspond à un programme d'archéologie expérimentale sur les techniques et les conditions de navigation précolombiennes dans les Antilles. Ces travaux réalisés dans un cadre scientifique contrôlé et complétés par une analyse des caractéristiques hydrostatiques du canot, nous ont ainsi permis d'obtenir un ensemble de données tout à fait inédites. Elles nous permettent de refonder notre approche de la relation des populations précolombiennes à l'espace archipélique antillais.
The Proceedings of the XXIII Congress of the International Association for Caribbean Archaeology, Antigua, 29 june-3 july 2009

hal-00966520
https://hal.univ-antilles.fr/hal-00966520
https://hal.univ-antilles.fr/hal-00966520/document
https://hal.univ-antilles.fr/hal-00966520/file/ioumoulicou.pdf

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The development of inflammatory granulomas around infected Kupffer cells is necessary for hepatic parasite clearance during visceral leishmaniasis. Invariant NKT (iNKT) cells are predominant T cells in the mouse liver and can synthesize large quantities of IL-4 and IFN-γ, two cytokines involved in granuloma formation. This study analyzed the role of iNKT cells in the hepatic immune response during Leishmania donovani infection, using a murine model of wild-type (WT) and iNKT cell-deficient (Jα18⁻/⁻) C57BL/6 mice sacrificed 15, 30 or 60 days post-infection. We recorded hepatic parasite loads, cytokine expression, and analyzed granulomatous response by immunohistochemistry and hepatic immune cell infiltration by flow cytometry. Whereas WT animals rapidly controlled the infection and developed an inflammatory response associated with a massive influx of iNKT cells observed by flow cytometry, Jα18⁻/⁻ mice had significantly higher parasitic loads on all time points. This lack of control of parasite burden was associated with a delay in granuloma maturation (28.1% of large granulomas at day 60 versus 50.7% in WT). Cytokine transcriptome analysis showed that mRNA of 90/101 genes encoding chemokines, cytokines and their receptors, was underexpressed in Jα18⁻/⁻ mice. Detection of IL-4 and TNF-α by ELISA in liver extracts was also significantly lower in Jα18⁻/⁻ mice. Consistent with flow cytometry analysis, cytokinome profile in WT mice showed a bias of expression towards T cell-chemoattractant chemokines on D15, and displayed a switch towards expression of granulocytes and/or monocytes -chemoattractant chemokines on D60. In Jα18⁻/⁻ mice, the significantly lower expression of CXCL5, MIP-2 and CCL2 mRNA was correlated with a defect in myeloperoxidase positive-cell attraction observed by immunohistochemistry and with a lower granulocyte and monocyte infiltration in the liver, as shown by flow cytometry. These data indicate that iNKT cells play a role in early and sustained pro-inflammatory cytokine response warranting efficient organization of hepatic granulomas and parasite clearance.
ISSN: 1932-6203

hal-00696897
https://hal.archives-ouvertes.fr/hal-00696897
https://hal.archives-ouvertes.fr/hal-00696897/document
https://hal.archives-ouvertes.fr/hal-00696897/file/Invariant_NKT_Cells_Drive-accepted.pdf
DOI : 10.1371/journal.pone.0033413

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Hepatocellular carcinoma (HCC) is a particularly severe disease characterized by a high rate of recurrence and death even after surgical resection. Molecular characterization of HCC helps refine prognosis and may facilitate the development of improved therapy. Phosphatidylinositol 4-kinases have recently been identified as cellular factors associated with cancer. Also, phosphatidylinositol 4-kinase type IIIα (PI4KA) is necessary for the propagation of the hepatitis C virus, a major etiological factor for HCC. METHODS: Reverse transcription, quantitative real-time PCR was used to assay PI4KA mRNA. The expression levels were investigated both in a collection of molecularly and clinically characterized hepatic tissues from 344 patients with diverse liver diseases and in human hepatocyte cell lines whose proliferative and differentiation status was controlled by specific culture conditions. Analytical microarray data for 60 HCC and six normal liver tissue samples were exploited to study correlations between PI4KA mRNA levels and cell proliferation markers in vivo. Postoperative disease-specific survival and time to recurrence in a set of 214 patients with HCC were studied by univariate and multivariate analyses. RESULTS: PI4KA mRNA was more abundant in HCC than normal healthy tissues. This upregulation correlated significantly with both poor differentiation and the active proliferation rate in HCC. These associations were confirmed with in vitro models. Moreover, patients with HCC who had been treated by surgical resection and had higher PI4KA mRNA concentrations in their tumor tissue exhibited a higher risk of tumor recurrence (median time: 20 months versus 49 months, P = 0.0012) and shorter disease-specific survival (first quartile time: 16 months versus 48 months, P = 0.0004). Finally, the abundance of PI4KA mRNA proved to be an independent prognostic marker of survival for cases of HCC (hazard ratio = 2.36, P = 0.0064). CONCLUSIONS: PI4KA mRNA could be used as a new molecular marker to improve established prognostic models for HCC. These findings also indicate possible new lines of research for the development of innovative therapeutic approaches targeting PI4KA.
ISSN: 1471-2407

inserm-00934294
http://www.hal.inserm.fr/inserm-00934294
http://www.hal.inserm.fr/inserm-00934294/document
http://www.hal.inserm.fr/inserm-00934294/file/1471-2407-14-7.pdf
DOI : 10.1186/1471-2407-14-7

Éditeur(s) : HAL CCSD
Résumé : International audience
Aegean extension is a process driven by slab rollback that, since 45 Ma, shows a twostage evolution. From Middle Eocene to Middle Miocene it is accommodated by localized deformation leading to i) the exhumation of high-pressure metamorphic rocks from mantle to crustal depths, ii) the exhumation of high-temperature rocks in core complexes and iii) the deposition of Paleogene sedimentary basins. Since Middle Miocene, extension is distributed over the whole Aegean domain giving a widespread development of onshore and offshore Neogene sedimentary basins. We reconstructed this two-stage evolution in 3D at Aegean scale by using available ages of metamorphic and sedimentary processes, geometry and kinematics of ductile deformation, paleomagnetic data and available tomographic models. The restorationmodel shows that the rate of trench retreat was around 0.6 cm/y during the first 30 My and then accelerated up to 3.2 cm/y during the last 15 My. The sharp transition observed in the mode of extension, localized versus distributed, which occurred in Middle Miocene correlates with the acceleration of trench retreat and is more likely a consequence of the Hellenic slab tearing documented by mantle tomography. The development of large dextral NE-SW strike-slip faults during the second stage of Aegean extension, since Middle Miocene, is illustrated by the 450 Km-long fault, recently put in evidence, offshore from Myrthes to Ikaria and onshore from Izmir to Balikeshir, in western Anatolia. Therefore, the interaction between the Hellenic trench retreat and the westward displacement of Anatolia started in Middle Miocene,almost 10 Ma before the propagation of the North Anatolian Fault in the North Aegean. This raises a fundamental issue concerning the dynamic relationship between slab tearing and Anatolia displacement
ISSN: 0438-9557

insu-01574659
https://hal-insu.archives-ouvertes.fr/insu-01574659
https://hal-insu.archives-ouvertes.fr/insu-01574659/document
https://hal-insu.archives-ouvertes.fr/insu-01574659/file/EFFECTS_OF_SLAB_ROLLBACK_ACCELERATION_ON_AEGEAN_EX.pdf
DOI : 10.12681/bgsg.11697

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
There are emerging concerns about potential effects on child health and development of early-life exposure to substances such as brominated flame retardants (BFRs), perfluorinated compounds (PFCs), phthalates and phenols (including bisphenol A (BPA)); pregnancy and birth cohort studies are ideally designed to study such concerns prospectively. As part of the ENRIECO project, we evaluated existing human biomonitoring data for these substances in European birth cohorts and develop recommendations for more harmonized methods that will enable combination and comparison of cohort data in the future. The ENRIECO inventory shows that 20 European birth cohorts have measured or are measuring BFRs (N=10), PFCs (N=11), phthalates (N=16) or phenols (N=8). Generally, samples were collected prenatally or at birth and measurements involved few subjects in each cohort (a few hundred maximum). Biological matrices, timing, and analytical methods of the measurements varied between cohorts. Few cohorts have measured at multiple time points or in children. In European cohorts, levels of BFRs were very low and at least 10-fold lower than in US; levels of PFCs and phthalates have decreased over the last decade since the phasing out of certain of these compounds; concentrations of phenols are comparable to those in the US. Although there is little published data in the cohorts now, many measurements are ongoing and we recommend that cohorts start working towards combined and comparison studies. Specific recommendations for use of existing data include the development of conversion models for the different media used for measurement of persistent chemicals, and inter-laboratory comparisons and calibrations. Recommendations for further data collection include more evaluation of exposure to these chemicals in children; repeated measurements of non-persistent chemicals; validation and harmonisation of questionnaires; and the development of mechanisms for fast European birth cohort response for the detection and prioritisation of new chemicals of concern.
ISSN: 1438-4639

hal-01118579
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118579
DOI : 10.1016/j.ijheh.2012.05.009
PUBMED : 22795704

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This paper aims to present an overview on the influence of rheological heterogeneity and mechanical anisotropy on the deformation of continents. After briefly recapping the concept of rheological stratification of the lithosphere, we discuss two specific issues: (1) as supported by a growing body of geophysical and geological observations, crust=mantle mechanical coupling is usually efficient, especially beneath major transcurrent faults which probably crosscut the lithosphere and root within the sublithospheric mantle; and (2) in most geodynamic environments, mechanical properties of the mantle govern the tectonic behaviour of the lithosphere. Lateral rheological heterogeneity of the continental lithosphere may result from various sources, with variations in geothermal gradient being the principal one. The oldest domains of continents, the cratonic nuclei, are characterized by a relatively cold, thick, and consequently stiff lithosphere. On the other hand, rifting may also modify the thermal structure of the lithosphere. Depending on the relative stretching of the crust and upper mantle, a stiff or a weak heterogeneity may develop. Observations from rift domains suggest that rifting usually results in a larger thinning of the lithospheric mantle than of the crust, and therefore tends to generate a weak heterogeneity. Numerical models show that during continental collision, the presence of both stiff and weak rheological heterogeneities significantly influences the large-scale deformation of the continental lithosphere. They especially favour the development of lithospheric-scale strike-slip faults, which allow strain to be transferred between the heterogeneities. An heterogeneous strain partition occurs: cratons largely escape deformation, and strain tends to localize within or at the boundary of the rift basins provided compressional deformation starts before the thermal heterogeneity induced by rifting are compensated. Seismic and electrical conductivity anisotropies consistently point towards the existence of a coherent fabric in the lithospheric mantle beneath continental domains. Analysis of naturally deformed peridotites, experimental deformations and numerical simulations suggest that this fabric is developed during orogenic events and subsequently frozen in the lithospheric mantle. Because the mechanical properties of single-crystal olivine are anisotropic, i.e. dependent on the orientation of the applied forces relative to the dominant slip systems, a pervasive fabric frozen in the mantle may induce a significant mechanical anisotropy of the whole lithospheric mantle. It is suggested that this mechanical anisotropy is the source of the so-called tectonic inheritance, i.e. the systematic reactivation of ancient tectonic directions; it may especially explain preferential rift propagation and continental break-up along pre-existing orogenic belts. Thus, the deformation of continents during orogenic events results from a trade-off between tectonic forces applied at plate boundaries, plate geometry, and the intrinsic properties (rheological heterogeneity and mechanical anisotropy) of the continental plates.
ISSN: 0040-1951

hal-01389719
http://hal.univ-reunion.fr/hal-01389719
http://hal.univ-reunion.fr/hal-01389719/document
http://hal.univ-reunion.fr/hal-01389719/file/vauchez_etal_rheology_1998_hal.pdf
DOI : 10.1016/S0040-1951(98)00137-1

Éditeur(s) : Man and Coastal Areas – Towards a sustainable Aquaculture, May 2000
Résumé : Fish culture (seabass, turbot...) on the French metropolitan coast, and shrimp culture in the overseas territories (essentially New Caledonia and Tahiti) are subject to a regular development through land based farms. Three thematic of research on aquaculture ponds are carried out in CREMA-L’Houmeau, in collaboration with producers. The aim of the first one is to determine the optimal rearing conditions (stocking density, water renewal rate, input of oxygen, rate of feeding...) which allow to minimise the quantity of wastes for a similar final biomass. The second part aims to reduce the nutrient loading in the effluent, through open-air treatments: sedimentation ponds, foam fractionation, mass production of phytoplankton, and rearing of molluscs on the produced phytoplankton. The third part concerns research aiming to model the “ production - treatment - valorisation ” relationships.

Droits : 2000 Ifremer
http://archimer.ifremer.fr/doc/00016/12728/9650.pdf
http://archimer.ifremer.fr/doc/00016/12728/

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Brazil and Canada have two of the biggest protected area systems in the world, both of them based in the protected areas model established by the USA in the XIX century. However, they have distinct policies when it comes to public use and ecotourism inside those areas. Canadian guidelines have a greater focus on leisure and recreation activities, in a more permissive use of its resources with activities geared to large scale tourism. On the other hand, Brazil has a focus more limited on low-impact activities with a strong component of environmental education and restrictions of activities within its protected areas. From that approach, this article analyzes the Brazilian and the Canadian public policies for public use development inside protected areas and how they address the three main aspects of ecotourism: environmental conservation, environmental awareness of visitors and involvement of local community.
Brésil et le Canada ont deux des plus grands réseaux d´aires protégées du monde, tous les deux basés dans le modèle d’aires protégées établi par les États-Unis au XIXe siècle. Cependant, ils ont des politiques distinctes quand il s´agit de l'usage du public et de l'écotourisme à l'intérieur de ces zones. Les lignes directrices canadiennes ont une plus grande focalisation sur les activités de loisirs et de détente, dans une utilisation plus permissive de ses ressources à des activités visant à grande échelle le tourisme. D'autre part le Brésil a un objectif plus limité sur les activités à faible impact avec une forte composante de l'éducation et les restrictions d'activités au sein de ses aires protégées de l'environnement. A partir de cette approche, cet article analyse les politiques publiques brésiliennes et canadiennes pour le développement du ecotourisme à l'intérieur d’aires protégées et de la façon dont ils abordent les trois principaux aspects de l'écotourisme: conservation de l'environnement, education environmental et la participation de la communauté locale.
Brésil
Canada
Colombie-Britannique
São Paulo

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.9344
http://journals.openedition.org/etudescaribeennes/9344

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Much debate exists concerning the strength distribution of the continental lithosphere, how it controls lithosphere-scale strain localization and hence enables plate tectonics. No rheological model proposed to date is comprehensive enough to describe both the weakness of plate boundary and rigid-like behaviour of plate interiors. Here we show that the duality of strength of the lithosphere corresponds to different stages of microstructural evolution. Geological constraints on lithospheric strength and large strain numerical experiments reveal that the development of layers containing weak minerals and the onset of grain boundary sliding upon grain size reduction in olivine cause strain localisation and reduce strength in the crust and subcontinental mantle, respectively. The positive feedback between weakening and strain localization leads to the progressive development of weak plate boundaries while plate interiors remain
ISSN: 0040-1951

insu-00949213
https://hal-insu.archives-ouvertes.fr/insu-00949213
https://hal-insu.archives-ouvertes.fr/insu-00949213/document
https://hal-insu.archives-ouvertes.fr/insu-00949213/file/Gueydan_et_al_2014.pdf
DOI : 10.1016/j.tecto.2014.02.005

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The Pyrenean peridotites (lherzolites) form numerous small bodies of subcontinental mantle, a few meters to 3 km across, exposed within the narrow north Pyrenean zone (NPZ) of Mesozoic sediments paralleling the north Pyrenean Fault. Recent studies have shown that mantle exhumation occurred along the future NPZ during the formation of the Albian-Cenomanian Pyrenean basins in relation with detachment tectonics. This paper reviews the geological setting of the Pyrenean lherzolite bodies and reports new detailed field data from key outcrops in the Bearn region. Only two types of geological settings have to be distinguished among the Pyrenean ultramafic bodies. In the first type (sedimented type or S type), the lherzolites occur as clasts of various sizes, ranging from millimetric grains to hectometric olistoliths, within monogenic or polymictic debris flow deposits of Cretaceous age, reworking Mesozoic sediments in dominant proportions as observed around the Lherz body. In the second type (tectonic type or T type), the mantle rocks form hectometric to kilometric slices associated with crustal tectonic lenses. Both crustal and mantle tectonic lenses are in turn systematically associated with large volumes of strongly deformed Triassic rocks and have fault contacts with units of deformed Jurassic and Lower Cretaceous sediments belonging to the cover of the NPZ. These deformed Mesozoic formations are not older that the Aptian-early Albian. They are unconformably overlain by the Albian-Cenomanian flysch formations and have experienced high temperature-low pressure mid-Cretaceous metamorphism at variable grades. Such a tectonic setting characterizes most of the lherzolite bodies exposed in the western Pyrenees. These geological data first provide evidence of detachment tectonics leading to manle exhumation and second emphasize the role of gravity sliding of the Mesozoic cover in the preorogenic evolution of the Pyrenean realm. In the light of such evidence, a simple model of basin development can be inferred, involving extreme thinning of the crust, and mantle uprising along a major detachment fault. We demonstrate coeval development of a crust-mantle detachment fault and generalized gravitational sliding of the Mesozoic cover along low-angle faults involving Triassic salt deposits as a tectonic sole. This model accounts for the basic characteristics of the precollisional rift evolution in the Pyrenean realm.
ISSN: 0278-7407

hal-00512818
https://hal.archives-ouvertes.fr/hal-00512818
DOI : 10.1029/2009TC002588

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Recent research has linked early life exposure to selective serotonin reuptake inhibitor medications (SSRIs) to modifications of social behaviors in children. Serotonin is a key regulator of neurodevelopment, social behaviors and mental health, and with the growing use of SSRIs to treat maternal affective disorders during the perinatal period, questions have been raised about the benefits and risks of perinatal SSRI exposure on the developing child. This review will highlight how perinatal SSRIs affect maternal care and neurodevelopmental outcomes related to social affiliative behaviors in offspring; such as play behaviors, social interactions, reproductive behaviors, and maternal care of the next generation. We will also review how early life exposure to SSRIs can alter related neurobiology, and the epigenome. Both clinical research and findings from animal models will be discussed. Understanding the impact of perinatal SSRIs on neurobehavioral outcomes will improve the health and well-being of subsequent generations.
ISSN: 0149-7634

hal-01619303
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01619303
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01619303/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01619303/file/Perinatal%20selective%20serotonin%20reuptake%20inhibitor%20medication_revised.pdf
DOI : 10.1016/j.neubiorev.2017.04.023

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
How reliable are shear wave splitting measurements as a means of determining mantle flow direction? This remains a topic of debate, especially in the context of subduction. The answer hinges on whether our current understanding of mineral physics provides enough to accurately translate between seismic observations and mantle deformation. Here, we present an integrated model to simulate strain-history-dependent texture development and estimate resulting shear wave splitting in subduction environments. We do this for a mantle flow model that, in its geometry, approximates the double-sided Molucca Sea subduction system in Eastern Indonesia. We test a single-sided and a double-sided subduction case. Results are compared to recent splitting measurements of this region by Di Leo et al. (2012a). The setting lends itself as a case study, because it is fairly young and, therefore, early textures from the slab's descent from the near surface to the bottom of the mantle transition zone--which we simulate in our models--have not yet been overprinted by subsequent continuous steady state flow. Second, it allows us to test the significance of the double-sided geometry, i.e., the need for a rear barrier to achieve trench-parallel subslab mantle flow. We demonstrate that although a barrier amplifies trench-parallel subslab anisotropy due to mantle flow, it is not necessary to produce trench-parallel fast directions per se. In a simple model of A-type olivine lattice-preferred orientation and one-sided subduction, trench-parallel fast directions are produced by a combination of simple shear and extension through compression and pure shear in the subslab mantle.
ISSN: 1525-2027

hal-01053506
https://hal.archives-ouvertes.fr/hal-01053506
DOI : 10.1002/2013GC005032

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Development of hepatocellular carcinoma (HCC) is a complex and progressive disease that involves cycles of liver cell death, inflammation, and tissue regeneration/remodelling. Chemokines and chemokine receptors play numerous and integral roles in the disease progression of HCC. Here we investigated the novel chemokine receptor CXCR7/RDC1 in HCC progression, its two known ligands CXCL12 and CXCL11, as well as the other CXCL12 receptor, CXCR4. Our results show that in a cohort of 408 human HCCs, CXCR7 and CXCL11 were significantly higher in tumours compared to normal liver controls (5- and 10-fold, respectively). Immunohistochemical (IHC) staining on human HCC sections confirmed that both CXCL11 and CXCR7 were much higher in cancer tissues. Furthermore, IHC staining revealed that CXCR7 protein was only expressed in endothelial cells whereas CXCL11 exhibited a much broader tissue expression. At the cellular level we observed that in vitro, human microvascular endothelial cells (HMEC-1) up-regulated CXCR7 under hypoxic and acidic pH conditions, which are well known characteristics of the HCC tumour micro-environment. As for its ligand, we observed that IFNγ robustly induced CXCL11 in hepatic stellate cells, hepatocytes, and HMEC-1s. In addition, in the mouse Diethylnitrosamine model of hepatocarcinogenesis we observed a very strong induction of CXCR7 and CXCL11 transcripts, confirming that CXCR7/CXCL11 up-regulation is conserved between human and mice liver cancer. Altogether, our results strongly support the hypothesis that the CXCL11/CXCR7 pathway is involved HCC progression.
ISSN: 0959-8049

hal-00682463
https://hal.archives-ouvertes.fr/hal-00682463
DOI : 10.1016/j.ejca.2011.06.044
PUBMED : 21778049

Éditeur(s) : HAL CCSD Taylor & Francis (Routledge)
Résumé : International audience
It was in 1969, six years after the creation of the first sports fédération for the physically disabled in France, that regular ties with the Ministry of Youth and Sports began to develop. The aim of this article is to question how these ties affected the development of the movement towards the model of ‘classic’ sports federations. Between 1968 and 1973, data from the Ministry of Youth and Sports kept in the National Archives, along with information published in the federal press (crossed with accounts from persons with prominent roles d in disabled sports at the time), reveals a reorganization of the internal relations between managers (who are physically disabled people) and doctors (who generally come from the field of re-education). These new circumstances entailed their collaboration with another federal agent, who consequently became centrally important: the sports technician.
ISSN: 1743-0437

hal-01681359
https://hal.archives-ouvertes.fr/hal-01681359
DOI : 10.1080/17430437.2016.1273610

Éditeur(s) : HAL CCSD
Résumé : International audience
The increasing development of world trade has promoted the spread of diseases. Recent events, like the H1N1 outbreak and spread, have confirmed this tendency. Everyone could observe that this kind of infectious disease often has the ability to cross countries borders and spread rapidly. Preventing, monitoring and controlling the outbreak of these diseases have appeared to be a public health problem of primary importance for years. However, although numerous works have been conducted in order to understand and study epidemics, this subject remains a topical issue because of the complexity of the phenomena. In this paper, we present new opportunities offered by the field of social networks for understanding the spread of infectious diseases. This work focuses both on techniques already used in epidemiology, and very recent works in social network analysis that open new perspectives. We give an overview of methods currently used to model and study the spread of diseases and future directions that the social network approach allows to glimpse.
2011 Fifth International Conference on Research Challenges in Information Science (RCIS)
Gosier, Guadeloupe

hal-00624364
https://hal.archives-ouvertes.fr/hal-00624364
DOI : 10.1109/RCIS.2011.6006866

Éditeur(s) : AgroParisTech, ABIES
Résumé : Aquaculture is one of the main supply of protein in feed for mankind, notably in Asia. It increases and had exceeded the level of production of world fisheries, which is decreasing. According to sites and rearing methods, aquaculture contributes to add value but also in some cases to impact negatively the aquatic ecosystems. In the coastal area, a rich and productive zone, but also a place of conflicts, this activity presents a high potential for development if it takes into account the rules of sustainability. The conditions of this sustainability may be cleared with appropriate methods of foresight analysis applied for each development project. The analysis of the professional experience of D. Lacroix for 33 years in aquaculture is structured in three steps. Firstly, the work is to check the scientific value of the research conducted under his responsibility in various contexts and for different responsibilities. This study refers to the requirements of a PhD. In the second part of the work, the results of few major projects (French West Indies, French Guyana….) are analysed with the support of the theory of translation (Callon et al) which allows to build a network of actors and to project it into the context. This way of study includes a special attention to the aspects of time planning, legitimacy and acceptability. Finally, the author examines how this knowledge gained from experience could help building a method for foresight analysis aiming at a shorter planning, a better timing and less means for future projects. To achieve this goal the author integrates the vision of the economist R. Passet which structures any project in an ecosystemic framework, including criteria of sustainability. The mix of these two approaches (Callon & Passet) entails in a new tool for foresight analysis, called Aster, which originality is to offer the possibility to test various scenarios and related consequences to help decision -makers. This new method of foresight analysis, is then tested on the well known case study of the development of prawn Macrobrachium rosenbergii in French Guyana. The test shows to be successful as it delivers precise and arguable recommendations about research and development for all stakeholders.
L'aquaculture est l'une des composantes principales de l'apport en protéines dans le monde, surtout en Asie. Elle croît, alors que la pêche, qu'elle a dépassée en tonnage comme en valeur, décline. Selon les écosystèmes et les méthodes employées, elle peut contribuer à valoriser, mais aussi à dégrader les milieux aquatiques. Dans la zone côtière, espace riche et productif au plan biologique mais convoité, l'aquaculture conserve un potentiel de développement si sa mise en œuvre intègre les principes de la durabilité. Celle-ci peut être éclairée par la prospective avec des méthodes d'analyse adaptées à chaque projet. L'analyse de l'expérience de 33 ans en aquaculture de D. Lacroix est faite en trois temps. D'abord, il s'agit de vérifier la qualité de ses travaux de recherche scientifique menés dans des contextes et avec des responsabilités variés en suivant la grille d'analyse de référence d'un doctorat. Ensuite, l'analyse consiste à prendre un recul critique sur les bilans de réalisations majeures (Antilles, Guyane…) en mobilisant l'approche de M. Callon dont la théorie de la traduction permet de construire le réseau des acteurs et de le projeter dans la problématique. Cette grille d'analyse est complétée par l'étude des aspects de temporalité, légitimité et d'acceptabilité pour chaque réalisation. Ce travail sur diverses situations d'intervention permet de préparer une réflexion sur la proposition méthodologique qui suit et son adaptation à des conditions variables. Enfin, les connaissances acquises sont synthétisées afin de construire une méthode de prospective qui permettrait de gagner en temps, en efficacité et en moyens sur des projets à venir. Pour cela, l'analyse s'appuie sur la vision de R. Passet, qui structure les éléments de tout projet dans la hiérarchie des composantes de la durabilité. Le système dynamique qui en résulte peut être alors croisé avec divers scénarios afin d'en simuler les conséquences et donc d‟éclairer les choix. Cette méthode, dite Aster, est testée sur le cas « modèle » et bien documenté de l'élevage de la crevette Macrobrachium rosenbergii en Guyane française. Elle permet d'aboutir à des recommandations précises et argumentées en matière de recherche comme de développement pour tout décideur impliqué.

Droits : 2010 The author, AgroParisTech, ABIES
http://archimer.ifremer.fr/doc/00032/14349/11633.pdf
http://archimer.ifremer.fr/doc/00032/14349/

Éditeur(s) : Université de Montpellier II
Résumé : The sea bass, Dicentrarchus labrax, has been subjected to intensive aquaculture on the Mediterranean cost for ten years. Marine fish hatcheries are key factors in the aquaculture field, and face different pathologies, especially one of viral origin (nodavirus) that could challenge their feasibility. Consequently, we have tried to provide some data on larvae and spawning stocks. Firstly, we have studied the immunoglobulins, components of the specific humoral immunity, and their role as antibodies. On adult basses, these immunoglobulins are tetrameric molecules with high molecular weight (850 kD), made of heavy (H) - 80 kD and light (L) - 26 kD chains. In the eggs, simplest forms such as monomeric or dimeric are brought to the fore; they are located under the chorionic membrane. Secondly, we have studied the development of the immunity system on larvae, preparing IgM assays with ELISA method, the study on the organogenesis of the main lymphoid organs, and using flow cytometry for the ontogenesis of IgM producing cell. Based on this experience, we can propose a date for the immunocompetence onset of the bar, i.e. from the 54th day of the hatchery phase. Finally, we made the most of these different results to study a viral pathology (nodavirus) in spawners and larvae. We defined an experimental contamination model for larvae and eggs, and we highlighted that eggs born from vaccinated hen fishes were protected against the nodavirus.
Le bar, Dicentrarchus labrax, fait l'objet d'une aquaculture intensive sur le littoral Méditerranéen depuis une dizaine d'années. Les écloseries marines représentent un des maillons clefs de cette filière aquacole, et sont confrontées à différentes pathologies, dont une d'origine virale (nodavirus), pouvant remettre en cause leur faisabilité. Aussi, nous avons tenté d'apporter quelques données concernant la protection des larves et des géniteurs reproducteurs. Dans un premier temps, nous avons étudié les immunoglobulines, éléments de l'immunité spécifique humorale ainsi que leur rôle anticorps. Chez les bars adultes ces immunoglobulines sont des molécules tétramériques de haut poids moléculaire (850 kD), composées de chaînes lourdes (H) de 80 kD et légères (L) de 26 kD. Dans les oeufs, des formes plus simples, monomériques ou dimériques, sont mises en évidence et sont localisées sous la membrane chorionique. Dans un second temps, nous avons étudié la mise en place du système immunitaire spécifique chez les larves, en effectuant le dosage des IgM par ELISA, l'étude de l'organogenèse des principaux organes lymphoïdes, puis celle de l'ontogenèse des cellules productrices d'IgM par cytométrie de flux. L'ensemble de cette étude nous permet de proposer une date d'acquisition de l'immunocompétence à partir du 54ème jour d'élevage chez le bar. Enfin, ces différents résultats ont été mis à profit dans le cadre d'une pathologie virale (nodavirus) touchant les reproducteurs et les larves. Après avoir défini un modèle de contamination expérimental des larves et des oeufs, nous avons mis en évidence une protection des oeufs lorsque ceux-ci proviennent d'une femelle vaccinée (vaccin expérimental) contre le nodavirus.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1997/these-1265.pdf
http://archimer.ifremer.fr/doc/00000/1265/

Éditeur(s) : HAL CCSD Société nationale de protection de la nature
Résumé : International audience
The island of Moorea in French Polynesia is representative of a relatively well preserved small tropical oceanic island but both its terrestrial and marine ecosystems are currently under strong anthropogenic pressures. The terrestrial ecosystems are facing an increasing urbanization, and the destruction and modification of their natural habitats by cultivation and forestry plantations, accidental or intentional fires, and particularly by the invasion of alien plant and animal species. Coastal areas and reef ecosystems are threatened by shoreline artificialization, sedimentation due to soil erosion, increasing uses of marine and lagoon resources and frequency of coral bleaching events. A significant erosion of terrestrial and marine biodiversity is observed on the island since the last decades. In the context of the Land Management Plan (PGA) and Marine Area Management Plan (PGEM) recently set up in the island by local authorities, scientific surveys and inventories were made in 2006 in order to assess the status of terrestrial biodiversity (vascular plants) and marine biodiversity (reef fishes) and compare areas with different anthropogenic pressures. Studies conducted on the flora and the vegetation at low and middle elevation along altitudinal transects show that the plant invasion process is related to climatic and topographic factors, and species autoecology. The marine study aims to compare the protected areas with control areas in order to test the effectiveness of protection measures and to propose a streamlined monitoring protocol. A methodological study in both terrestrial and marine ecosystems was conducted in order to propose biodiversity indicators which are crucial for decision making in conservation and sustainable development of island biodiversity. We used Geographic Information System (GIS) as a fast and intuitive tool for mapping indicators and their variability. This methodological approach developed on the island of Moorea could be used as a model for other tropical islands
Moorea est une petite île océanique tropicale de la Polynésie française relativement bien préservée, mais dont les écosystèmes terrestres et marins sont actuellement soumis à de fortes pressions anthropiques. Le milieu terrestre est confronté à une urbanisation croissante, à la destruction ou à la modification des habitats naturels pour l’extension des cultures ou des plantations forestières, aux incendies volontaires ou accidentels, et particulièrement à l’invasion d’espèces végétales et animales introduites. Les zones côtières et les récifs coralliens sont menacés par de multiples perturbations telles que l’artificialisation des lignes de rivage, l’apport de sédiments dus à l’érosion des sols, l’augmentation des usages des ressources marines et lagonaires et de la fréquence des phénomènes de blanchissement du corail. Une érosion sensible de la biodiversité terrestre et marine de l’île est observée depuis les dernières décennies. Dans le cadre du Plan Général d’Aménagement (PGA) et du Plan de Gestion de l’Espace Maritime (PGEM) mis en place par les autorités locales, des inventaires scientifiques ont été réalisés en 2006 dans le but d’évaluer l’état de la biodiversité terrestre (plantes vasculaires) et marine (poissons récifaux) et de comparer des zones soumises à différentes perturbations. Les études réalisées sur la flore et la végétation de basse et moyenne altitude le long de transects altitudinaux montrent des processus d’invasion végétale différents en relation avec les facteurs climatiques, topographiques et autoécologiques des espèces. Les études en milieu marin visent à comparer des aires protégées à des aires témoins afin de suivre l’efficacité des mesures de gestion. La réflexion méthodologique menée parallèlement sur les deux écosystèmes a pour but d’illustrer différents indices de biodiversité nécessaires à la prise de décision en matière de conservation ou de développement durable de la biodiversité insulaire et de réaliser un état de référence pour établir un diagnostic sur l’état de la biodiversité. La représentation cartographique des indices à l’aide d’un SIG, illustrée dans cette étude avec la richesse spécifique terrestre et marine, permet une lecture intuitive et rapide de la variabilité de cet indice dont la restitution est basée sur une standardisation du nombre d’espèces. Cette approche méthodologique développée sur l’île de Moorea pourrait servir de modèle pour d’autres îles tropicales
EISSN: 2429-6422

hal-01306285
https://hal-univ-perp.archives-ouvertes.fr/hal-01306285

Éditeur(s) : HAL CCSD American Society for Biochemistry and Molecular Biology
Résumé : International audience
The budding yeast Saccharomyces cerevisiae is a major model organism for important biological processes such as mitotic growth and meiotic development, it can be a human pathogen, and it is widely used in the food-, and biotechnology industries. Consequently, the genomes of numerous strains have been sequenced and a very large amount of RNA profiling data is available. Moreover, it has recently become possible to quantitatively analyze the entire yeast proteome; however, efficient and cost-effective high-throughput protein profiling remains a challenge. We report here a new approach to direct and label-free large-scale yeast protein identification using a tandem buffer system for protein extraction, two-step protein prefractionation and enzymatic digestion, and detection of peptides by iterative mass spectrometry. Our profiling study of diploid cells undergoing rapid mitotic growth identified 86% of the known proteins and its output was found to be widely concordant with genome-wide mRNA concentrations and DNA variations between yeast strains. This paves the way for comprehensive and straightforward yeast proteome profiling across a wide variety of experimental conditions.
ISSN: 1535-9476

hal-00682837
https://hal.archives-ouvertes.fr/hal-00682837
DOI : 10.1074/mcp.M111.012682
PUBMED : 21997732

Éditeur(s) : HAL CCSD
Résumé : International audience
The goal of our experiment is to develop a useful and accessible tool that can be used to evaluate a patient's health by analyzing handwritten strokes. We use a cloud computing approach to analyze stroke data sampled on a commercial tablet working on the Android platform and a distant server to perform complex calculations using the Delta and Sigma lognormal algorithms. A Google Drive account is used to store the data and to ease the development of the project. The communication between the tablet, the cloud and the server is encrypted to ensure biomedical information confidentiality. Highly parameterized biomedical tests are implemented on the tablet as well as a free drawing test to evaluate the validity of the data acquired by the first test compared to the second one. A blurred shape model descriptor pattern recognition algorithm is used to classify the data obtained by the free drawing test. The functions presented in this paper are still currently under development and other improvements are needed before launching the application in the public domain.
17th Biennial Conference of the International Graphonomics Society
Pointe-à-Pitre, Guadeloupe

hal-01165890
https://hal.univ-antilles.fr/hal-01165890
https://hal.univ-antilles.fr/hal-01165890/document
https://hal.univ-antilles.fr/hal-01165890/file/IGS_2015_submission_20.pdf