Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
The Chaînons Béarnais ranges (North-Pyrenean Zone, west-central Pyrenees) display a fold-and-thrust structure involving the Mesozoic sedimentary cover, decoupled from its substratum at the Keuper evaporites level and associated with a few peridotite bodies and scarce Palaeozoic basement lenses. In the western part of the Chaînons Béarnais, the newly described recumbent fold of the Saraillé massif comprises a peridotite body and several lenses of Palaeozoic basement wrapped by the Triassic to Aptian sedimentary cover. This structure represents a remnant of the distal portion of the Pyrenean paleo-rifted margin where mantle rocks have been exhumed during Albian–Cenomanian times. In this paper, we present the first detailed mapping and microstructural analysis of the Saraillé massif, providing new geological basis for reconstructing the evolution of this part of the paleo-margin. Our mapping (i) shows that the pre-rift Mesozoic cover forms a recumbent fold cored by mantle and crustal rocks and (ii) confirms that the prerift cover was detached from its bedrock along a layer of Triassic evaporites and slid onto the exhumed mantle rocks. Sliding of the prerift cover was associated with extreme crustal thinning and mantle exhumation along a major detachment fault, together with intense metasomatism affecting both the continental basement and the sedimentary cover. We show for the first time (1) that the Mesozoic pre-rift sediments experienced syn-metamorphic ductile thinning during mantle exhumation, and (2) that during its extreme attenuation, the continental basement was reduced to tectonic lenses some ten meters thick by ductile shearing.
ISSN: 1631-0713

insu-01265777
https://hal-insu.archives-ouvertes.fr/insu-01265777
https://hal-insu.archives-ouvertes.fr/insu-01265777/document
https://hal-insu.archives-ouvertes.fr/insu-01265777/file/corre-CRGeosc-2016.pdf
DOI : 10.1016/j.crte.2015.11.007

Éditeur(s) : John Wiley & Sons
Résumé : Based on all available seismic refraction data, the seismic structure of the Western Approaches to the English Channel and the South Armorican continental shelf has been established. The correlation of seismic velocities showed a three-fold structure, related to geological layers as follows: 1. High-velocity, deep sequence (4.4-6.6km/sec): metamorphic basement and Lower to Middle Palaeozoic. 2. Intermediate sequence (3.6-4.3km/sec): Permo-Triassic (and Jurassic?) and possibly also Lower Cretaceous on the margin of the Western Approaches. 3. Upper sequence (1.9-3.6km/sec): Cretaceous and Cenozoic sediments. An acoustic unconformity appears to be present between the Upper sequence and the High velocity and Intermediate sequences. Different geomorphology characterizes these layers: the Palaeozoic is tectonized and generally follows the Hercynian structural trends; mainly Permo-Triassic sediments fill the depressions of the Palaeozoic floor, but only in the Western Approaches; eastwards-transgressive Cretaceous and Cenozoic sediments cover discordantly the preceding layers. [NOT CONTROLLED OCR]
Petroleum and the continental shelf of North-west Europe (John Wiley & Sons), 1975 , P. 29-43

Droits : John Wiley & Sons
http://archimer.ifremer.fr/doc/1975/publication-5465.pdf
http://archimer.ifremer.fr/doc/00000/5465/

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
BACKGROUND: Histoplasmosis is an endemic fungal infection in French Guiana. It is the most common AIDS-defining illness and the leading cause of AIDS-related deaths. Diagnosis is difficult, but in the past 2 decades, it has improved in this French overseas territory which offers an interesting model of Amazonian pathogen ecology. The objectives of the present study were to describe the temporal trends of incidence and mortality indicators for HIV-associated histoplasmosis in French Guiana. METHODS: A retrospective study was conducted to describe early mortality rates observed in persons diagnosed with incident cases of HIV-associated Histoplasma capsulatum var. capsulatum histoplasmosis admitted in one of the three main hospitals in French Guiana between 1992 and 2011. Early mortality was defined by death occurring within 30 days after antifungal treatment initiation. Data were collected on standardized case report forms and analysed using standard statistical methods. RESULTS: There were 124 deaths (45.3%) and 46 early deaths (16.8%) among 274 patients. Three time periods of particular interest were identified: 1992-1997, 1998-2004 and 2005-2011. The two main temporal trends were: the proportion of early deaths among annual incident histoplasmosis cases significantly declined four fold (χ2, p<0.0001) and the number of annual incident histoplasmosis cases increased three fold between 1992-1997 and 1998-2004, and subsequently stabilized. CONCLUSION: From an occasional exotic diagnosis, AIDS-related histoplasmosis became the top AIDS-defining event in French Guiana. This was accompanied by a spectacular decrease of early mortality related to histoplasmosis, consistent with North American reference center mortality rates. The present example testifies that rapid progress could be at reach if awareness increases and leads to clinical and laboratory capacity building in order to diagnose and treat this curable disease.
ISSN: 1935-2727

inserm-01065109
http://www.hal.inserm.fr/inserm-01065109
http://www.hal.inserm.fr/inserm-01065109/document
http://www.hal.inserm.fr/inserm-01065109/file/PLOS_Neglected_Tropical_Dis_2014.pdf
http://www.hal.inserm.fr/inserm-01065109/file/2014_Adenis_-_HIV-associated_histoplasmosis_early_mor.pdf

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : The Mesozoic series of the southern units of the Pyrenean Empordà thrust sheets (Montgrí and Figueres nappes, Catalonia, Spain) were finally emplaced over the autochthonous basement and its Cenozoic cover during Eocene times. However, they have originally been folded by the "Laramian" compressional event (Late Cretaceous/Early Paleocene), while they were still in their root zone more than 50 km to the N-NE. Postdating the Santonian, the emersion of the Cretaceous tectorogen induced karst formation at the expense of Berriasian to Santonian limestone sequences. Karst cavities of this paleokarst 1 (lapiaz and canyons) were subsequently coated with a fine, red or black, Microcodium-bearing, continental silt, and infilled with marine chaotic breccias. Following a new episode of emersion then erosion, the original paleokarst 1 was cross-cut by newly formed cavities of the paleokarst 2, filled with Lutetian-Bartonian marine breccias. Both types of marine breccias (Paleocene then Eocene in age) are now relatively well dated by means of planktonic foraminifera (Globigerinacea) occurring within the argillaceous-sandy matrix, and for the older ones, within the argillaceous-sandy or carbonate, finely laminated, interbedded hemipelagites, that mark the top of marine sequences tens of centimetres thick. The relationships of the "Laramian" and "Pyrenean" compressional tectonic events, occurring from latest Cretaceous to Bartonian, with the development of paleokarsts 1 and 2 are analysed in the perspective of the progressive southwards emplacement of the Montgrí thrust sheet, during Eocene time.
EISSN: 1777-5817

hal-00405328
https://hal.archives-ouvertes.fr/hal-00405328
DOI : 10.2113/gssgfbull.178.1.15

Éditeur(s) : HAL CCSD
Résumé : Different applications of linear elasticity in structural geology are presented in this thesis through the development of three types of numerical computer codes. The first one uses forward modeling to study displacement and perturbed stress fields around complexly faulted regions. We show that incorporating inequality constraints, such as static Coulomb friction, enables one to explain the angle of initiation of jogs in extensional relays. Adding heterogeneous material properties and optimizations, such as parallelization on multicore architectures and complexity reduction, admits more complex models. The second type deals with inverse modeling, also called parameter estimation. Linear slip inversion on faults with complex geometry, as well as paleo-stress inversion using a geomechanical approach, are developed. The last type of numerical computer code is dedicated to restoration of complexly folded and faulted structures. It is shown that this technique enables one to check balanced cross-sections, and also to retrieve fault chronology. Finally, we show that this code allows one to smooth noisy 3D interpreted faulted and folded horizons using geomechanics.
Différentes applications de l'élasticité linéaire en géologie structurale sont présentées dans cette thèse à travers le développement de trois types de codes numériques. Le premier utilise la modélisation directe pour étudier les déplacements et champs de contraintes autour de zones faillées complexes. On montre que l'ajout de contraintes inégalitaires, telles que la friction de Coulomb, permet d'expliquer l'angle d'initiation des dominos dans les relais extensifs. L'ajout de matériaux hétérogènes et d'optimisations, telles la parallélisation sur processeurs multi-coeurs ainsi que la réduction de complexité des modèles, permettent l'étude de modèles beaucoup plus complexes. Le second type de code numérique utilise la modélisation inverse, aussi appelée estimation de paramètres. L'inversion linéaire de déplacements sur les failles ainsi que la détermination de paléo-contraintes utilisant une approche géomécanique sont développées. Le dernier type de code numérique concerne la restauration de structures complexes plissées et faillées. Il est notamment montré qu'une telle méthode permet de vérifier l'équilibre de coupes géologiques, ainsi que de retrouver la chronologie des failles. Finalement, nous montrons que ce même code permet de lisser des horizons 3D faillés, plissés et bruités en utilisant la géomécanique.
https://tel.archives-ouvertes.fr/tel-00537899

tel-00537899
https://tel.archives-ouvertes.fr/tel-00537899
https://tel.archives-ouvertes.fr/tel-00537899/document
https://tel.archives-ouvertes.fr/tel-00537899/file/thesemaerten.pdf

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
We present a 2-D Contact Dynamics discrete element model for simulating initiation and motion of rock avalanches, integrating hillslope geometry, Mohr-Coulomb rock behavior, pore pressure before avalanche triggering, and avalanche trigger. Avalanche motion is modeled as a dense granular flow of dry frictional and cohesive particles. On the basis of granular physics and shear experiments, we review some of the theories for the unexpectedly long runout of rock avalanches. Different causes are evoked, according to the strength (strong or weak) of the slip surface relative to the bulk. "Mechanical fluidization'' and "acoustic fluidization'' theories state that agitation of rock particles reduces frictional strength, increasing runout. Conversely, granular mechanics suggests that, as "shear-strain'' rate increases, granular material becomes more agitated, more dissipative, and more resistant. Another theory states that dynamic fragmentation of clasts creates an isotropic pressure that drives longer runout. In contrast, granular mechanics suggests that fragmentation may induce fluidization and strengthening of the granular material, while particle size reduction (among others) induces weakening of the granular flow and enhances long runout. Runout is also enhanced for column-like rock masses collapsing from steep hillslopes. Long runout may also be linked to thermal weakening mechanisms at the slip surface (e.g., thermal pressurization, and shear melting), which may lower drastically the shear strength. The model is illustrated with a hypothetical example of a rain-triggered avalanche, mobilizing shallowly dipping layers. Several phases are identified, including slope failure, avalanche triggering resulting from slip weakening, and avalanche motion in which rocks are folded and sheared.
ISSN: 0148-0227

hal-00420883
https://hal.archives-ouvertes.fr/hal-00420883
DOI : 10.1029/2008JF001072

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Diffusion parameters for HTO, 36Cl−, and 125I− were determined on Upper Toarcian argillite samples from the Tournemire Underground Research Laboratory (Aveyron, France) using the through diffusion technique. The direction of diffusion was parallel to the bedding plane. The purpose of the present study was 3-fold; it was intended (i) to confirm the I− interaction with Upper Toarcian argillite and to verify the effects of initial I− concentration on this affinity, as previously observed by means of radial diffusion experiments, (ii) to highlight any discrepancy between Cl− and I− diffusivity, and (iii) to investigate the effect of an increase of the ionic strength of the solution on the anionic tracers' diffusive behaviour. The results show that the effective diffusion coefficient (De) and diffusion accessible porosity (εa) values obtained with an ionic strength (I.S.) synthetic pore water of 0.01 eq L−1 are: De = 2.35-2.50 × 10−11 m2 s−1 and εa = 12.0-15.0% for HTO, and De = 14.5-15.5 × 10−13 m2 s−1 and εa = 2.5-2.9% for 36Cl−. Because of anionic exclusion effects, anions diffuse slower and exhibit smaller diffusion accessible porosities than HTO, taken as a water tracer. The associated effective diffusion coefficient (De) and rock capacity factor (α) obtained for 125I are: De = 7.00-8.60 × 10−13 m2 s−1 and α = 4.3-7.2%. Such values make it possible to calculate low 125I distribution ratios (0.0057 < RD < 0.0192 mL g−1) which confirm the trend indicating that the 125I rock capacity factor increases with the decrease of the initial I− concentration. Additional through-diffusion experiments were carried out with a higher ionic strength synthetic pore water (I.S. = 0.11 eq L−1). No evolution of HTO diffusion parameters was observed. The anionic tracers' effective diffusion coefficient increased by a factor of two but no clear evolution of their accessible porosity was observed. Such a paradox could be related to the particularly small mean pore size of the Upper Toarcian argillite of Tournemire. The most significant finding of this study is the large discrepancy (factor of two) between the values of the effective diffusion coefficient for 125I and 36Cl. Whatever the ionic strength of the synthetic solution used, 125I exhibited De values two times lower than those of 36Cl. A detailed explanation for this difference cannot be given at present even if a hypothesis based on ion-pairing or on steric-exclusion cannot be excluded. This makes questionable the assumption usually made for quantifying 125I sorption and postulating that 36Cl and 125I would diffuse in the same porosity. In other terms, at Tournemire, 125I sorption could be more pronounced than previously indicated.
ISSN: 0883-2927

hal-00757749
https://hal.archives-ouvertes.fr/hal-00757749
DOI : 10.1016/j.apgeochem.2011.12.017

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Superposed to ductile syn-metamorphic deformations, post-foliation deformations affect metamorphic units during their exhumation. Understanding the role of such deformations in the structuration of metamorphic units is key for understanding the tectonic evolution of convergence zones. We characterize post-foliations deformations using 3D modelling which is a first-order tool to describe complex geological structures, but a challenging task where based only on surface data. We propose a modelling procedure that combines fast draft models (interpolation of orientation data), with more complex ones where the structural context is better understood (implicit modelling), allowing us to build a 3D geometrical model of Syros Island blueschists (Cyclades), based on field data. With our approach, the 3D model is able to capture the complex present-day geometry of the island, mainly controlled by the su-perposition of three types of post-metamorphic deformations affecting the original metamorphic pile: i) a top-to-South ramp-flat extensional system that dominates the overall island structure, ii) large-scale folding of the metamorphic units associated with ramp-flat extensional system, and iii) steeply-dipping normal faults trending dominantly NNW-SSE and EW. The 3D surfaces produced by this method match outcrop data, are geologically consistent, and provide reasonable estimates of geological structures in poorly constrained areas.
ISSN: 0191-8141

insu-01188400
https://hal-insu.archives-ouvertes.fr/insu-01188400
DOI : 10.1016/j.jsg.2015.07.002

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
New magnetotelluric and receiver transfer function studies provide insights from the upper to the lower crust of the eastern Betic Cordillera, which is deformed by large folds, normal faults, and a major transcurrent left-lateral fault, the Carboneras Fault Zone (CFZ). Receiver function analysis determines a NNW dipping Moho reaching 20 degrees that increases in depth, from 20 km south of the CFZ up to 34 km in the Sierra de Los Filabres. In addition, seismic discontinuities determined in the upper crust are interpreted as major contacts between metamorphic complexes that are detached and folded. The MT inversion model reveals a conductive zone, also representing a crustal seismic discontinuity, associated with the Alpujarride/Nevado-Filabride contact and fitting the N vergent geometry of the Sierra Alhamilla antiform. A small flexure at Moho coincides with the CFZ, as revealed by the Bouguer anomaly trend, in agreement with the receiver function results. Moreover, the Bahr strike and tipper angle at the stations placed closest to the CFZ clearly reveal the continuity of the CFZ at least down to approximately 15 km in depth, crossing all the detected crustal discontinuities up to the Moho. The lack of a clear Moho offset associated with the Carboneras Fault supports the idea that some large strike-slip faults tend to accommodate the deformation by a broadening fault zone at lower crustal levels. Its nucleation could occur at the base of a thin crust, where melting processes critically reduced the lithospheric strength during the late Miocene, to then propagate upward, reaching the topographic surface. Northward, the lithosphere comprised moderately larger strength, and the crustal discontinuities favored the development of larger folds with kilometric amplitude instead of strike-slip faults since the late Miocene.
ISSN: 1525-2027

hal-00671024
https://hal.archives-ouvertes.fr/hal-00671024
DOI : 10.1029/2010GC003274

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
A new genus and species of deep-sea eelpout (Zoarcidae), Barbapellis pterygalces, is herein described from a single adult female specimen carrying eggs and measuring 204 mm in total length. It was collected on the eastern Antarctic continental slope, off Terre Ad,lie, at ca. 1,200 m depth, on muddy bottom. Barbapellis is placed in the subfamily Gymnelinae and can be distinguished from all other genera by morphological characters unusual in zoarcids as well as by molecular barcoding. The genus is characterized by the presence of a complex system of cephalic skin crests and flaps, especially well developed around the mouth. A new terminology is proposed for the eleven crests and sevenfolds described. The skin folds may be used for foraging on muddy sea bottoms. The genus is also characterized by large, flexible, and highly palmate pectoral fins. The designation of the new genus is discussed.
ISSN: 0722-4060

hal-01544913
https://hal.archives-ouvertes.fr/hal-01544913
DOI : 10.1007/s00300-011-1057-3

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
Detailed seafloor mapping in the area east of Taiwan revealed trench-parallel stretching and folding of the Ryukyu forearc and lateral motion of the accretionary wedge under oblique convergence. East of 122ø40'E, a steep accretionary wedge is elongated in an E-W direction. A major transcurrent right-lateral strike-slip fault accommodates the strain partitioning caused by an oblique convergence of 40 ø. A spectacular out-of-sequence thrust may be related to the subduction of a structural high lying in the axis of the N-S trending Gagua Ridge. This asperity is likely responsible for the uplift of the accretionary wedge and forearc basement and may have augmented strain partitioning by increasing the coupling between the two plates. West of 122ø40'E, the low-taper accretionary wedge is sheared in a direction subparallel to the convergence vector with respect to the Ryukyu Arc. The bayonet shape of the southern Ryukyu Arc slope partly results from the recent (re)opening of the southern Okinawa Trough at a rate of about 2 to 4 cm/yr. Right-lateral shearing of the sedimentary forearc with respect to the nonlinear Ryukyu backstop generates trench-parallel extension in the forearc sediment sequence at dilational jogs and trench-parallel folding at compressive jogs. The Hoping Basin lies above a diffuse trench/trench/fault (TTF) or TFF unstable triple junction moving toward the south along a N-S transform zone which accommodates the southward drift of the Ryukyu Arc with respect to Eurasia.
ISSN: 0278-7407

hal-01261555
https://hal.archives-ouvertes.fr/hal-01261555
https://hal.archives-ouvertes.fr/hal-01261555/document
https://hal.archives-ouvertes.fr/hal-01261555/file/Lallemand_et_al-1999-Tectonics.pdf
DOI : 10.1029/1998TC900011

Éditeur(s) : HAL CCSD Elsevier
Résumé : This contribution reports our preliminary work to determine Cu isotope ratios for various granite rocks and examine the Cu isotope systematics within granite suites. A chemical procedure, modified from Marechal [Marechal, C.N., Telouk, R and Albarede, F., 1999. Precise analysis of copper and zinc isotopic compositions by plasma-source mass spectrometry. Chemical Geology, 156(1-4): 251-273.], Was used to separate Cu from rock matrix. Quantitative recovery (100.6 +/- 1.6%), with a low total procedural blank (2.65 +/- 0.66 ng) for Cu, has been achieved, allowing Cu isotopic measurements on samples with as little as 10 ppm Cu. The Cu isotope ratios (delta Cu-65 relative to NIST SRM 976) of 32 rock samples, ranging from mafic to felsic compositions, from 3 batholiths (2 I-type, 1 S-type) from the Lachlan Fold Belt in southeastern Australia. vary from -0.46 parts per thousand to 1.51 parts per thousand. Most of them cluster around zero, With mean values for the I-type and S-type granites of 0.03 +/- 0.15 parts per thousand and - 0.03 +/- 0.42 parts per thousand (2 sigma) respectively. These data, together with Cu isotope ratios of two loess samples, provide preliminary evidence that the baseline Cu isotopic composition of the crystalline part of upper continental crust is close to zero. The tight clustering of Cu isotope ratios of rocks from the I-type suites Suggests that high-temperature magmatic processes do not produce significant Cu isotope fractionation. However, two granites with abnormally heavy Cu isotope signatures (up to 1.51 parts per thousand) appears to be the result of localized hydrothermal alteration. Measurable variation in Cu isotopic composition of the S-type granite may reflect isotopic heterogeneity in the sedimentary Source region as a result of redox processes or may be due to hydrothermal overprinting. Thus, Cu isotope geochemistry may be a useful tracer for studying hydrothermal alteration and Source heterogeneity of granitic rocks.
ISSN: 0009-2541

hal-00413130
https://hal.archives-ouvertes.fr/hal-00413130
DOI : 10.1016/j.chemgeo.2008.06.047

Éditeur(s) : Université de la Polynésie Française
Résumé : The ontogeny of osmoregulation was studied in the blue shrimp Litopenaeus stylirostris in New Caledonia. The implication of branchial organs in ionic regulation was first demonstrated in juveniles by immunolocalization of three ion transporting proteins ( namely NKA, co-transporter NKCC1 and CFTR ) and ionocyte detection was done by means of electron microscopy. The role of the main ion transporting enzyme, NKA, was subsequently investigated during post-embryonic development using an integrative approach associating physiological, histological, immunological and biomolecular studies. Results obtained allowed us to propose a model of the osmoregulatory pattern in L. stylirostris based on weak regulation in the early stages, then progressively this species acquires the adult pattern of hyper-hypo-regulation after metamorphosis with the concurrent development of epipodites and gills. Strong NKA immunofluorescence and abundance of NKA transcripts in these two tissues compared to others organs suggest their functional implication in osmoregulatory processes. The results of this study allow us to increase our knowledge of the penaeid shrimp osmoregulation and to propose zootechnical measures to improve the animal physiological comfort. These propositions have been already tested during larval rearing trials, leading a two-fold-growth in 19 days-old postlarvae.
L’étude de l’ontogenèse de l’osmorégulation a été entreprise chez la crevette bleue Litopenaeus stylirostris en Nouvelle-Calédonie. L’implication des tissus de la cavité branchiale dans la régulation ionique a été déterminée au préalable chez des juvéniles par immunolocalisation de trois transporteurs protéiques d’ions, ( la NKA, le co-transporteur NKCC1 et le CFTR ) et par la détection de ionocytes en microscopie électronique. Le rôle de la NKA a été particulièrement étudié et son implication a été examinée au cours du développement post-embryonnaire par une approche intégrative associant des études physiologiques, histologiques, immunologiques et moléculaires. Cette démarche nous a permis de proposer un modèle d’osmorégulation chez L. stylirostris: de faible régulatrice dans les premiers jours de sa vie, cette espèce évolue vers l’hyper-hypo-régulation après la métamorphose avec le développement progressif des épipodites et des branchies. L’immunofluorescence prononcée de la NKA ainsi que l’abondance des transcrits du gène codant la NKA dans les tissus de ces deux organes suggèrent leur implication fonctionnelle dans l’ionorégulation. Les résultats de ce travail nous ont permis d’accroître nos connaissances sur l’osmorégulation chez les pénéidés et de proposer des améliorations zootechniques visant à augmenter leur confort physiologique. Ces préconisations ont fait l’objet de premiers essais en conditions d’élevage et se sont traduites par un doublement de la croissance des post-larves de 19 jours.

Droits : 2011 The author, Univ. Polynésie Française
http://archimer.ifremer.fr/doc/00052/16314/13816.pdf
http://archimer.ifremer.fr/doc/00052/16314/

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case-control study comprised 410 patients who had surgery for a pituitary tumour with long-term follow-up. Using pituitary magnetic resonance imaging for diagnosis of cavernous or sphenoid sinus invasion, immunocytochemistry, markers of the cell cycle (Ki-67, mitoses) and p53, tumours were classified according to size (micro, macro and giant), type (PRL, GH, FSH/LH, ACTH and TSH) and grade (grade 1a: non-invasive, 1b: non-invasive and proliferative, 2a: invasive, 2b: invasive and proliferative, and 3: metastatic). The association between patient status at 8-year follow-up and age, sex, and classification was evaluated by two multivariate analyses assessing disease- or recurrence/progression-free status. At 8 years after surgery, 195 patients were disease-free (controls) and 215 patients were not (cases). In 125 of the cases the tumours had recurred or progressed. Analyses of disease-free and recurrence/progression-free status revealed the significant prognostic value (p < 0.001; p < 0.05) of age, tumour type, and grade across all tumour types and for each tumour type. Invasive and proliferative tumours (grade 2b) had a poor prognosis with an increased probability of tumour persistence or progression of 25- or 12-fold, respectively, as compared to non-invasive tumours (grade 1a). This new, easy to use clinicopathological classification of pituitary endocrine tumours has demonstrated its prognostic worth by strongly predicting the probability of post-operative complete remission or tumour progression and so could help clinicians choose the best post-operative therapy.
ISSN: 0001-6322

hal-00875723
https://hal.archives-ouvertes.fr/hal-00875723
DOI : 10.1007/s00401-013-1084-y
PUBMED : 23400299

Éditeur(s) : Academic Press Ltd- Elsevier Science Ltd
Résumé : The understanding of reciprocal interactions between Crassostrea gigas and Vibrio sp., whether these be virulent or avirulent, is vital for the development of methods to improve the health status of cultured oysters. We describe an original non-invasive experimental infection technique using cohabitation, designed to explore these interactions. Using real-time PCR techniques we examined the dynamics of virulent and avirulent Vibrio sp. in oyster hemolymph and tank seawater, and made a parallel study of the expression of four genes involved in oyster immune defense: Cg-BPI, Cg-EcSOD, Cg-IκB, Cg-TIMP. No mortality occurred in control animals, but oysters put in cohabitation for 2–48 h with animals previously infected by two Vibrio pathogens suffered mortalities from 2 to 16 days post-cohabitation. Our results show that virulent Vibrio infect healthy individuals after only 2 h of cohabitation, with values ranging from 4.5×102 to 2×104 cells ml−1 hemolymph. Simultaneously, an approximate ten-fold increase of the total Vibrio population was observed in control animals, with a 6.6–78.5-fold up-expression of targeted genes. In contrast, oysters exposed to harmful bacteria had mean expression levels strongly down-regulated by a factor of 9.2–29 (depending on the gene) compared with control animals. Although oysters were still found to be infected by virulent Vibrio after 6–48 h of cohabitation, no significant differences were noted when comparing levels of each transcript in control and infected oysters at the same sampling times during this period: the important differences were noted before 6 h cohabitation. Taken together, our data support (1) the hypothesis that virulent Vibrio disturbs the immune response of this invertebrate host both rapidly and significantly, although this occurs specifically during an early and transient period during the first 6 h of cohabitation challenge, and that (2) expression of targeted genes is not correlated with vibriosis resistance.
Fish & Shellfish Immunology (1050-4648) (Academic Press Ltd- Elsevier Science Ltd), 2011-02 , Vol. 30 , N. 2 , P. 691-699

Droits : 2011 Elsevier Ltd All rights reserved.
http://archimer.ifremer.fr/doc/00025/13604/10681.pdf
DOI:10.1016/j.fsi.2010.12.017
http://archimer.ifremer.fr/doc/00025/13604/

Éditeur(s) : HAL CCSD
Résumé : International audience
The geology of the North Pyrenean Zone in the central Pyrenees allows for the observation in the field of theentire section of the Pyrenean rift, from the mantle to the crust and the Mesozoic cover (pre, syn and post rift).The good knowledge we have of the pre-Alpine history of the Pyrenees allows us to properly constrain the Alpinegeological evolution of the pre-Triassic rocks which record both Variscan and Alpine orogenic cycles.The mantle outcrop as kilometric to centimetric fragments of peridotite dispersed within a carbonate metamorphicbreccia. The study of peridotite serpentinisation shows several events of low-temperature serpentinisation, incontact with seawater. In some locallities, we can observe a mixture of fragments of variously serpentinizedperidotites. This suggests a tectonic context where fragments of peridotites from different structural levels weresampled more or less synchronously.The granulitic basement is characterized by a Variscan syndeformational HT event (300-280 Ma). So farwe have not found any trace of a Cretaceous HT event (> 500C). On the other hand, the basement is affectedby a regional metasomatism that began during the Jurassic and became more spatially focused with time until itwas restricted to the Pyrenean rift during the Aptien, Albian and Cenomanian. The talc-chlorite metasomatism(120-95 Ma) shows an evolution from a static toward a syn-deformation hydrothermal event, under a more or lessnormal geothermal gradient. Extensional deformation is recorded by the reworking of several inherited low-angleVariscan tectonic contacts, but also by dispersed high-angle extensional shear zones formed under greenshistconditions.The metamorphic Mesozoic cover of the basement massifs, which constitute the so-called Internal MetamorphicZone, is an allochtonous unit made of lenses of Mesozoic rocks enclosed into the breccia, whichlocally contains peridotite and basement clasts. The Mesozoic metamorphic carbonates show a first phase ofsyn-metamorphic (450-600C, P < 2 kb) ductile deformation, and subsequent phases of folding and fracturing.The datation of neoformed minerals give a 108-85 Ma time span for the metamorphism. We interpret this brecciaas an abandonment breccia which marks the emergence of the main detachment. The basal contact of the Mesozoiccover has a complex 3D geometry traced by Triassic evaporites. It corresponds to a major pre- and synorogenicpolyphased tectonic contact.All these data show a geometrically complex hyper-extended rift where the crust was not stretched under ahigh geothermal gradient but thinned by the tectonic extraction of relatively thin lenses and perhaps cut by highangle low-grade shear zones. The 3D geometry, as well as the strain records and the breccia lithologies stronglysuggest a non-cylindricity for the exhumation process, probably within a transtentional system
Geophysical Research Abstracts
Vienne, Austria

insu-01510371
https://hal-insu.archives-ouvertes.fr/insu-01510371

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Cycladic Blueschist Unit (CBU) represents the northern passive margin of the Adria continental block and ophiolites that are the remnants of the Pindos Ocean, which were affected by high pressure-low temperature metamorphism in the blueschist and eclogite facies during the Eocene. Prior to the Lutetian, the ophiolitic and margin units were thrust towards the SW inside a NE-dipping subduction zone. Two subsequent exhumation stages are characterized by top-to-the-NE senses of shear: i) from mantle depths to lower crustal levels, before 37 Ma, which was accommodated by an extensional inversion of the Vardar suture zone, and ii) from deep crustal levels to the near-surface, between 30 and 20 Ma, which was accommodated by the North Cycladic Detachment. It is during this late stage of ductile exhumation that the central Cyclades Core Complex was exhumed. Segmentation of the CBU by normal faults started at 12 Ma, as recorded by the low temperature thermochronometers, and was coeval with block rotation and folding with NS-trending axes, which were predominantly controlled by the Myrthes-Ikaria strike-slip fault in the centre of the Cyclades. A map restoration of the CBU geometry, prior to segmentation, has been carried out using available structural and paleomagnetic data. The restoration shows that, following the CBU exhumation from mantle depths to crustal levels, a single core complex was exhumed along a single NE dipping detachment.
ISSN: 0040-1951

insu-00672320
https://hal-insu.archives-ouvertes.fr/insu-00672320
DOI : 10.1016/j.tecto.2011.12.025

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
The chemical and isotopic compositions of clay minerals such as illite and chlorite are commonly used to quantify diagenetic and low-grade metamorphic conditions, an approach that is also used in the present study of the Monte Perdido thrust fault from the South Pyrenean fold-and-thrust belt. The Monte Perdido thrust fault is a shallow thrust juxtaposing upper Cretaceous-Paleocene platform carbonates and Lower Eocene marls and turbidites from the Jaca basin. The core zone of the fault, about 6 m thick, consists of intensely deformed clay-bearing rocks bounded by major shear surfaces. Illite and chlorite are the main hydrous minerals in the fault zone. Illite is oriented along cleavage planes while chlorite formed along shear veins (<50 μm in thickness). Authigenic chlorite provides essential information about the origin of fluids and their temperature. δ18O and δD values of newly formed chlorite support equilibration with sedimentary interstitial water, directly derived from the local hanging wall and footwall during deformation. Given the absence of large-scale fluid flow, the mineralization observed in the thrust faults records the P-T conditions of thrust activity. Temperatures of chlorite formation of about 240°C are obtained via two independent methods: chlorite compositional thermometers and oxygen isotope fractionation between cogenetic chlorite and quartz. Burial depth conditions of 7 km are determined for the Monte Perdido thrust reactivation, coupling calculated temperature and fluid inclusion isochores. The present study demonstrates that both isotopic and thermodynamic methods applied to clay minerals formed in thrust fault are useful to help constrain diagenetic and low-grade metamorphic conditions.
ISSN: 0010-7999

hal-00757736
https://hal.archives-ouvertes.fr/hal-00757736
DOI : 10.1007/s00410-011-0718-0

Éditeur(s) : HAL CCSD Geological Society of London
Résumé : International audience
In Eastern China, the North China Block (NCB) has experienced a complex tectonic evolution during Late Palaeozoic to Mesozoic times. The unconformable sedimentary cover, which ranges in age from Neoproterozoic to Permian, underwent two tectonic episodes in Early Triassic and Cretaceous times. An early north–south compressional phase, D1, characterized by north-verging recumbent folds with east–west-trending axes and top-to-the-north ductile shear zones can be observed in a gabbroic pluton and the Neoproterozoic sedimentary host rocks. The available radiometric ages allow us to interpret this event as an Early Triassic back-thrusting related to the final stage of the collision between the North China and South China Blocks. During the LateMesozoic, an extensional event characterized by (1) half-grabens filled by continental terrigeneous red beds and lava flows, (2) low-angle detachment faults, (3) synkinematic granitic plutons, and (4) metamorphic core complexes is widespread in the Eastern Liaoning Peninsula. This extensional D2 event can be subdivided into a ductile deformation and a brittle deformation, corresponding to different expressions of crustal deformation. In every area studied in the Eastern Liaoning Peninsula, the ductile D2 deformation is characterized by a NW–SE-trending stretching lineation with a top-to-the-NWsense of shear.Mica and amphibole fromthe metamorphic country rocks, granodioritic or monzogranitic plutons and their mylonitized margins yield 40Ar/39Ar ages ranging from 130 to 120 Ma. These dates support fast cooling and exhumation rates coeval with the extensional tectonics. The brittle D2 deformation is responsible for the formation of high-angle normal faults marked by low-temperature cataclasites bounding half-grabens. During the Mesozoic, the tectonic regime of Eastern China experienced a significant inversion from compression to extension. The Eastern Liaoning Peninsula massif provides an example of this geodynamic transition.
ISSN: 2041-4927

hal-00134055
https://hal-insu.archives-ouvertes.fr/hal-00134055
DOI : 10.1144/SP280.7

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The late Carboniferous accretionary system of the South Tianshan orogen (North-Western China) underwent complex structural and polymetamorphic evolution. Combined petrological, geochronological and microstructural analysis of (ultra)high-pressure (UHP) metabasites (eclogites and blueschists) enclosed in metapelites show a relict coarse-grained eclogitic fabric S2 surrounded by a dominant fine-grained eclogite and blueschist facies retrograde fabric S2. The S2 fabric is reworked by upright folds F3 that are responsible for a major shortening of the whole accretionary system. For both the eclogite and blueschist, peak and retrograde P–T conditions have been thermodynamically constrained at 25–26 kbar and 425–500 °C and 10–13 kbar and 500−550 °C respectively, suggesting a shared exhumation history. The garnet-whole rock-amphibole isochron in the blueschist yielded Lu–Hf and Sm–Nd ages of 326.0 ± 2.9 Ma and 318.4 ± 3.9 Ma respectively, interpreted to date the prograde to peak metamorphic assemblage. The retrograde path of the eclogite is characterized by heterogeneous omphacite recrystallization into a mylonitic fine-grained matrix and crystallization of blue amphibole. Microstructures in both pristine porphyroclastic and recrystallized fine-grained domains in the eclogite indicate a gradual evolution from constriction-dominated (L>S-type) to flattening-dominated (S>L-type) type of deformation, increase of fabric intensity reflected by gradually growing M-indexes and the development of lattice preferred orientation (LPO) typical for dislocation creep under slightly hydrated conditions. Recrystallization of the matrix in the blueschist is homogeneous, which indicates a matrix dominated channel flow during exhumation. These LPOs evolutions suggest a significant mechanical coupling with the upper plate concomitant with oroclinal bending of the Kazakh orocline. Lock up of Kazakh orocline is responsible for further stress increase resulting in horizontal shortening of South Tianshan accretionary wedge and development of D3 upright folding and steepening of the whole sequence.
ISSN: 1342-937X

hal-01481263
https://hal.archives-ouvertes.fr/hal-01481263
DOI : 10.1016/j.gr.2016.07.007