Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Patterns of connectivity and self-recruitment are recognized as key factors shaping the dynamics of marine populations. Connectivity is also essential for maintaining and restoring natural ecological processes with genetic diversity contributing to the adaptation and persistence of any species in the face of global disturbances. Estimates of connectivity are crucial to inform the design of both marine protected areas (MPAs) and MPA networks. Among several approaches, genetic structure is frequently used as a proxy for patterns of connectivity. Using 8 microsatellite loci, we investigated genetic structure of the two-banded sea bream Diplodus vulgaris, a coastal fish that is both commercially and ecologically important. Adults were sampled in 7 locations (stretches of coastline approximately 8 km long) and juveniles in 14 sites (~100 to 200 m of coastline) along 200 km of the Apulian Adriatic coast (SW Adri-atic Sea), within and outside an MPA (Torre Guaceto MPA, Italy). Our study found similar genetic diversity indices for both the MPA and the surrounding fished areas. An overall lack of genetic structure among samples suggests high gene flow (i.e. connectivity) across a scale of at least 200 km. However, some local genetic divergences found in two locations demonstrate some heterogeneity in processes renewing the population along the Apulian Adriatic coast. Furthermore, two sites appeared genetically divergent, reinforcing our observations within the genetic makeup of adults and confirming heterogeneity in early stage genetics that can come from either different supply populations or from chaotic genetic patchiness occurring under temporal variation in recruitment and in the reproductive success. While the specific role of the MPA is not entirely known in this case, these results confirm the presence of regional processes and the key role of connectivity in maintaining the local population supply.
ISSN: 1932-6203

hal-01442055
https://hal-univ-perp.archives-ouvertes.fr/hal-01442055
https://hal-univ-perp.archives-ouvertes.fr/hal-01442055/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01442055/file/journal.pone.0167441.pdf
DOI : 10.1371/journal.pone.0167441.s009

Éditeur(s) : HAL CCSD Federation of American Society of Experimental Biology
Résumé : International audience
The innate immune system is able to detect bacterial LPS through the pattern recognition receptor CD14, which delivers LPS to various TLR signaling complexes that subsequently induce intracellular proinflammatory signaling cascades. In a previous study, we showed the overproduction of the soluble form of CD14 (sCD14) by macrophages from patients with cystic fibrosis (CF). CF is an autosomal recessive disorder that is caused by mutations in the gene that encodes the CFTR protein and is characterized by persistent inflammation. Macrophages play a significant role in the initial stages of this disease due to their inability to act as suppressor cells, leading to chronic inflammation in CF. In this work, we investigated the origin of sCD14 by human macrophages and studied the effect of sCD14 on the production of inflammatory cytokine/chemokine. Our data indicate that sCD14 stimulate proinflammatory cytokine/chemokine production in a manner that is independent of LPS but dependent on the TLR-4/CD14 membrane complex, NF-κB, and the inflammasome. Therefore, sCD14, overproduced by CF macrophages, originates primarily from the endocytosis/exocytosis process and should be considered to be a danger-associated molecular pattern. This elucidation of the origin and inflammation-induced mechanisms associated with sCD14 contributes to our understanding of maintained tissue inflammation.
ISSN: 0892-6638

hal-01526434
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01526434
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01526434/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01526434/file/Soluble%20CD14%20acts%20as%20a%20DAMP%20in%20human-accepted.pdf
PUBMED : 28122919

Éditeur(s) : HAL CCSD Wiley
Résumé : Question: To establish a habitat classification based on functional group co-occurrence that may help the drawing up of conservation plans. Location: Riverine forest fragments in the Grand-duché de Luxembourg, Europe. Methods: Forest fragments were surveyed for their abundance of vascular plants. These were clustered into emergent groups according to 14 life-traits related 10 plant dispersal, establishment and persistence. Forest fragments were classified according to similar distribution of the identified emergent groups. Environmental factors were related to the emergent group richness in each forest type using generalized linear models. Results: Contrary to former species centred classification, only two groups of forests, each with clearly different emergent group composition and conservation requirements. Were detected: (1) swamp forests characterized by anemogamous perennials, annuals and hydrochorous perennials and (2) moist forests characterized by barochorous perennials, small geophytes and zoochorous phanerophytes. From a conservation point of view, priority should he given to large swamp forest with intact flooding regimes his is in accordance with the high wind and water dispersal capacities of their typical emergent groups. For the moist forests. conservation priorities should he high forest connectivity and historical continuity since dispersal and establishment of their characteristic emergent groups arc highly limited. Conclusions: The described methodology, situated at an intermediate integration level between the individual species and whole community descriptors. takes advantage of both conservation plans built for single species and the synthetic power of bread ecological measures.
ISSN: 1402-2001

hal-01031884
https://hal.archives-ouvertes.fr/hal-01031884

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Organochlorine (OC) pesticides constitute a major class of persistent and toxic organic pollutants, known to modulate drug-detoxifying enzymes. In the present study, OCs were demonstrated to also alter the activity and expression of human hepatic drug transporters. Activity of the sinusoidal influx transporter OCT1 (organic cation transporter 1) was thus inhibited by endosulfan, chlordane, heptachlor, lindane, and dieldrine, but not by dichlorodiphenyltrichloroethane isomers, whereas those of the canalicular efflux pumps MRP2 (multidrug resistance-associated protein 2) and BCRP (breast cancer resistance protein) were blocked by endosulfan, chlordane, heptachlor, and chlordecone; this latter OC additionally inhibited the multidrug resistance gene 1 (MDR1)/P-glycoprotein (P-gp) activity. OCs, except endosulfan, were next found to induce MDR1/P-gp and MRP2 mRNA expressions in hepatoma HepaRG cells; some of them also upregulated BCRP. By contrast, expression of sinusoidal transporters was not impaired (organic anion-transporting polypeptide (OATP) 1B1 and OATP2B1) or was downregulated (sodium taurocholate co-transporting polypeptide (NTCP) and OCT1). Such regulations of drug transporter activity and expression, depending on the respective nature of OCs and transporters, may contribute to the toxicity of OC pesticides.
ISSN: 1095-6670

hal-01063656
https://hal.archives-ouvertes.fr/hal-01063656
DOI : 10.1002/jbt.21543
PUBMED : 24464585

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Fungi are major contributors to the opportunistic infections that affect patients with HIV/AIDS. Systemic infections are mainly with Pneumocystis jirovecii (pneumocystosis), Cryptococcus neoformans (cryptococcosis), Histoplasma capsulatum (histoplasmosis), and Talaromyces (Penicillium) marneffei (talaromycosis). The incidence of systemic fungal infections has decreased in people with HIV in high-income countries because of the widespread availability of antiretroviral drugs and early testing for HIV. However, in many areas with high HIV prevalence, patients present to care with advanced HIV infection and with a low CD4 cell count or represent with persistent low CD4 cell counts because of poor adherence, resistance to antiretroviral drugs, or both. Affordable, rapid point-of-care diagnostic tests (as have been developed for cryptococcosis) are urgently needed for pneumocystosis, talaromycosis, and histoplasmosis. Additionally, antifungal drugs, including amphotericin B, liposomal amphotericin B, and flucytosine, need to be much more widely available. Such measures, together with continued international efforts in education and training in the management of fungal disease, have the potential to improve patient outcomes substantially.
ISSN: 1473-3099

inserm-01574426
http://www.hal.inserm.fr/inserm-01574426
http://www.hal.inserm.fr/inserm-01574426/document
http://www.hal.inserm.fr/inserm-01574426/file/2017%2C%20Limper%20-%20Fungal%20infections%20in%20HIV%20AIDS.pdf
DOI : 10.1016/S1473-3099(17)30303-1

Éditeur(s) : HAL CCSD
Résumé : International audience
Treatment failure and symptomatic relapse are major concerns in American tegumentary leishmaniasis (ATL). Such complications are seen frequently in L.guyanensis infections where patients respond variously to first-line anti-leishmanials and are more prone to develop chronic cutaneous leishmaniasis. The factors underlying this pathology, however, are unknown. Recently ,: we reported that a dsRNA virus (LRV1) nested within L.guyanensis parasites is able to exacerbate experimental murine leishmaniasis by inducing a hyper-inflammatory response. This report investigates the prevalence of LRV1 in human L.guyanensis infection and its effect on treatment efficacy as well as its correlation to symptomatic relapses after the first-line treatment. In our cohort of 75 patients diagnosed with primary-localised ATL, the prevalence of LRV1+ infection was elevated to 58%. All patients infected with LRV1-negative L.guyanensis were cured after one (22/31 i.e.71%) or two (31/31 i.e.100%) doses of pentamidine. Oppositely, 12 out of the 44 LRV1-positive patients presented with persistent infection and symptomatic relapse required extended therapy and the use of second-line drugs. Finally, LRV1 presence was associated with a significant increase in intra-lesional inflammatory markers. In conclusion, LRV1 status in L.guyanensis infection is significantly predictive (p=0.0009) of first-line treatment failure and symptomatic relapse, and could stand to guide therapeutic choices in ATL
Journal of Infectious Diseases

hal-01175528
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01175528
DOI : 10.1093/infdis/jiv355
PUBMED : 26123564

Éditeur(s) : HAL CCSD
Résumé : National audience
Introduction Le chikungunya (CHIKV) est un alphavirus ré-émergent depuis 10 ans responsable de nombreuses épidémies. Chez certains patients, il est à l'origine de troubles musculo-squelettiques et de polyarthropathies inva-lidants et persistants plus de 3 mois, définissant la forme chronique du chikun-gunya (CHIKC). Afin de déterminer la prévalence du CHIKC, nous avons mené une cohorte prospective de patients ambulatoires lors de la dernière épi-démie en outre-mer. Secondairement, nous avons recherché les facteurs de risques associés.
Médecine et maladies infectieuses 46 (2016) 15-16
Lille, France

inserm-01413489
http://www.hal.inserm.fr/inserm-01413489
http://www.hal.inserm.fr/inserm-01413489/document
http://www.hal.inserm.fr/inserm-01413489/file/2016%2C%20Thioune%20-%20COL%207-01%20%281%29.pdf
http://www.hal.inserm.fr/inserm-01413489/file/2016%2C%20Thioune%20-%20COL%207-01.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Dahomey belt in Togo and Benin is an important segment of the larger West Gondwana Orogen. Here, we review the geodynamic evolution of the Dahomey belt and discuss new U–Pb and Lu–Hf zircon data in light of similar data previously acquired on the geologically related Northern Borborema Province, in NE Brazil. Eighteen samples from different tectonic settings and regions within the belt were collected for zircon isotopic investigation. Passive margin deposits of the Atacora Structural Unit and lower units of the Volta Basin have detrital zircon signatures compatible with the flanking West Africa Craton. The arc-related magmatism resulted from the east-dipping subduction of the Goiás-Pharusian oceanic lithosphere and is represented by a variety of granitoids emplaced in the Benino-Nigerian Shield between 670 and 610 Ma. These granitoids were mainly sourced from crustal reservoirs with subordinate juvenile input. Detrital zircon ages from syn-orogenic deposits in Benino-Nigerian Shield suggest that arc development could have started as early as 780 Ma. The main period of melting in the internal part of the belt, the Benino-Nigerian Shield, is related to crustal thickening and occurs only ca. 30 m.y. after initiation of the continental collision, marked by the ca. 610 Ma ultra-high pressure (UHP) metamorphism recorded at Lato Hills. Foreland development represented by the upper units of the Volta basin developed soon after continental collision and persisted with the development of the west-verging thrust front synchronously with the main period of crustal melting due to collision at ca. 580 Ma. The subvertical Transbrasiliano Lineament in South America, that corresponds to the Kandi Lineament in Africa, provides a present-day fit between NW Africa and NE Brazil. Restoration of the movement of the Transbrasiliano-Kandi Lineament (strike-slip plate boundary) places the Dahomey belt and Borborema Province (NE Brazil) along the same section of the West Gondwana Orogen. This configuration would explain some of the misfits previously discussed in the literature and aligns the UHP eclogites in Togo and NE Brazil.
ISSN: 0301-9268

hal-01358584
https://hal.archives-ouvertes.fr/hal-01358584
DOI : 10.1016/j.precamres.2016.01.032

Résumé : Après un rappel des objectifs, du fonctionnement et de la méthode d’interprétation des résultats du réseau de contrôle microbiologique REMI et du réseau de surveillance chimique ROCCH, ce rapport inclut un bilan national et décrit le programme annuel du département du Morbihan. Il présente l’ensemble des résultats obtenus, en particulier l’estimation de la qualité microbiologique et chimique des zones de production de coquillages classées. L’évaluation de la qualité des zones de production sur la période 2012-2014 (2011-2014 pour les classements saisonniers) révèle une qualité B pour neuf zones actuellement classées A pour le groupe 3 (dont 6 zones classées en A de façon saisonnière) et une qualité C pour quatre zones actuellement classées B pour le groupe 2 (dont 1 zone classée en B de façon saisonnière). L’année 2014 a vu une diminution considérable du nombre d’alertes par rapport à 2013, avec 9 alertes de niveau 1 (déclenchées dans le cadre de la surveillance régulière) dont 3 avec persistance de la contamination (alerte de niveau 2). L’analyse statistique des tendances sur les 10 dernières années ne met en évidence aucune tendance pour la plupart des zones. Seules six zones confirment une tendance à la dégradation. La qualité chimique est très satisfaisante sur toutes les stations.

Droits : 2015 Ifremer
http://archimer.ifremer.fr/doc/00260/37094/35604.pdf
http://archimer.ifremer.fr/doc/00260/37094/

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
S U M M A R Y Over the last decade, thermomechanical models have revealed the control of both tectonics and erosion on the morphology of continental plateaus margins. However, unravelling the specific effects of these two coupled processes has been difficult in practice. Here, to assess the control of erosion, we investigate the dynamics of the eastern and the northern borders of the Tibetan Plateau, which are characterized by a low convergence rate and a steep topographic escarpment adjacent to the Sichuan and Tarim basins, respectively. Thermomechanical modelling of continental lithosphere coupled with fluvial denudation reveals that important crustal deformation with large-scale horizontal displacements can occur, without any convergence, as a response to mass transfer due to gravitational collapse and to erosional unloading. These processes are sensitive to crustal structure, geothermal gradient as well as surface erosion. At a timescale of several million years, our results suggest that this denudation-triggered deformation exerts a primary control on the evolution of those plateau margins by counterbalancing the mass removal due to erosion and stabilizing the topographic escarpment. This finding supports a possible explanation for the morphology of the Longmen Shan, eastern Tibet, in which the paradoxical combination of persistent high-topographic gradients close to the foreland and low convergence rates can be related to the influence of erosion on deformation patterns.
ISSN: 0956-540X

hal-01577060
https://hal-amu.archives-ouvertes.fr/hal-01577060
https://hal-amu.archives-ouvertes.fr/hal-01577060/document
https://hal-amu.archives-ouvertes.fr/hal-01577060/file/godard2009erosional.pdf
DOI : 10.1111/j.1365-246X.2009.04324.x

Éditeur(s) : HAL CCSD National Institute of Environmental Health Sciences
Résumé : International audience
Background: Infant exposure to persistent organic pollutants (POPs) may contribute to obesity. However, many studies so far have been small, focused on transplacental exposure, used an inappropriate measure to assess postnatal exposure through breastfeeding if any, or did not discern between prenatal and postnatal effects.Objectives: We investigated prenatal and postnatal exposure to POPs and infant growth (a predictor of obesity).Methods: We pooled data from seven European birth cohorts with biomarker concentrations of polychlorinated biphenyl 153 (PCB-153) (n = 2,487), and p,p´-dichlorodiphenyldichloroethylene (p,p´-DDE) (n = 1,864), estimating prenatal and postnatal POPs exposure using a validated pharmacokinetic model. Growth was change in weight-for-age z-score between birth and 24 months. Per compound, multilevel models were fitted with either POPs total exposure from conception to 24 months or prenatal or postnatal exposure.Results: We found a significant increase in growth associated with p,p´-DDE, seemingly due to prenatal exposure (per interquartile increase in exposure, adjusted β = 0.12; 95% CI: 0.03, 0.22). Due to heterogeneity across cohorts, this estimate cannot be considered precise, but does indicate that an association with infant growth is present on average. In contrast, a significant decrease in growth was associated with postnatal PCB-153 exposure (β = –0.10; 95% CI: –0.19, –0.01).Conclusion: To our knowledge, this is the largest study to date of POPs exposure and infant growth, and it contains state-of-the-art exposure modeling. Prenatal p,p´-DDE was associated with increased infant growth, and postnatal PCB-153 with decreased growth at European exposure levels.
ISSN: 0091-6765

hal-01196597
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01196597
DOI : 10.1289/ehp.1308005
PUBMED : 25742056

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
OBJECTIVES: The ANRS-112 INTERPRIM trial assessed whether fixed-cycles of antiretroviral treatment interruption (ART-STI) combined or not with pegylated interferon alpha-2b (peg-IFN) could lower viral load and achieve a healthier immune system in patients diagnosed during primary HIV-1-infection (PHI). DESIGN AND METHODS: Patients were randomized to receive either continuous ART (cART) during 72 weeks, or cART during 36 weeks followed by three ART-STIs, or the same ART-STIs associated with peg-IFN during the first 14 weeks and each interruption (ART-STI-IFN). Treatment was stopped at week 72. Final evaluation was based on plasma HIV-RNA level 6 months after the last treatment interruption. RESULTS: Eighty-seven percent of patients achieved undetectable HIV-RNA at week 32, with no deleterious impact of sequential treatment interruptions (STIs). Viral rebounds during interruptions were lower in the ART-STI-IFN than in the ART-STI group and during the second and third interruptions compared with the first one. However, HIV-RNA levels, CD4 T-cell counts and CD4 T/CD8 T ratios were similar between groups after the 6-month interruption, with a persistent effect on CD4 T cells and total cell-associated HIV-DNA levels. Predictive factors of virological outcome were HIV-RNA and HIV-DNA levels at PHI and HIV-DNA levels at treatment interruption. HIV-specific responses did not differ between strategies and were not associated with outcome. Forty-eight percent of patients experienced treatment resumption during long-term follow-up without difference between groups. CONCLUSION: When initiated during PHI, STIs associated or not with IFN did not result in a different outcome as compared to cART. All regimens showed a high response rate and a sustained immunological benefit after cessation.
ISSN: 0269-9370

hal-00875175
https://hal.archives-ouvertes.fr/hal-00875175
DOI : 10.1097/QAD.0b013e32835844d9
PUBMED : 22842994

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The common endosymbiotic Wolbachia bacteria influence arthropod hosts in multiple ways. They are mostly recognized for their manipulations of host reproduction, yet, more recent studies demonstrate that Wolbachia also impact host behavior, metabolic pathways and immunity. Besides their biological and evolutionary roles Wolbachia are new potential biological control agents for pest and vector management. Importantly, Wolbachia-based control strategies require controlled symbiont transfer between host species and predictable outcomes of novel Wolbachia-host associations. Theoretically, this artificial horizontal transfer could inflict genetic changes within transferred Wolbachia populations. This could be facilitated through de novo mutations in the novel recipient host or changes of haplotype frequencies of polymorphic Wolbachia populations when transferred from donor to recipient hosts. Here we show that Wolbachia resident in the European cherry fruit fly, Rhagoletis cerasi, exhibit ancestral and cryptic sequence polymorphism in three symbiont genes, which are exposed upon microinjection into the new hosts Drosophila simulans and Ceratitis capitata. Our analyses of Wolbachia in microinjected D. simulans over 150 generations after microinjection uncovered infections with multiple Wolbachia strains in trans-infected lines that had previously been typed as single infections. This confirms the persistence of low-titer Wolbachia strains in microinjection experiments that had previously escaped standard detection techniques. Our study demonstrates that infections by multiple Wolbachia strains can shift in prevalence after artificial host transfer driven by either stochastic or selective processes. Trans-infection of Wolbachia can claim fitness costs in new hosts and we speculate that these costs may have driven the shifts of Wolbachia strains that we saw in our model system.
ISSN: 1932-6203

hal-01544765
https://hal.archives-ouvertes.fr/hal-01544765
DOI : 10.1371/journal.pone.0082402

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Among persisting questions on bone calcification, a major one is the link between protein expression and mineral deposition. A cell culture system is here proposed opening new integrative studies on biomineralization, improving our knowledge on the role played by non-collagenous proteins in bone. This experimental in vitro model consisted in human primary osteoblasts cultured for 60 days at the surface of a 3D collagen scaffold mimicking an osteoid matrix. Various techniques were used to analyze the results at the cellular and molecular level (adhesion and viability tests, histology and electron microscopy, RT-and qPCR) and to characterize the mineral phase (histological staining, EDX, ATG, SAED and RMN). On long term cultures human bone cells seeded on the osteoid-like matrix displayed a clear osteoblast phenotype as revealed by the osteoblast-like morphology, expression of specific protein such as alkaline phosphatase and expression of eight genes classically considered as osteoblast markers, including BGLAP, COL1A1, and BMP2. Von Kossa and alizarine red allowed us to identify divalent calcium ions at the surface of the matrix, EDX revealed the correct Ca/P ratio, and SAED showed the apatite crystal diffraction pattern. In addition RMN led to the conclusion that contaminant phases were absent and that the hydration state of the mineral was similar to fresh bone. A temporal correlation was established between quantified gene expression of DMP1 and IBSP, and the presence of hydroxyapatite, confirming the contribution of these proteins to the mineralization process. In parallel a difference was observed in the expression pattern of SPP1 and BGLAP, which questioned their attributed role in the literature. The present model opens new experimental possibilities to study spatio-temporal relations between bone cells, dense collagen scaffolds, NCPs and hydroxyapatite mineral deposition. It also emphasizes the importance of high collagen density environment in bone cell physiology.
ISSN: 1932-6203

hal-01142641
http://hal.upmc.fr/hal-01142641
http://hal.upmc.fr/hal-01142641/document
http://hal.upmc.fr/hal-01142641/file/Silvent_2013_Collagen.pdf
DOI : 10.1371/journal.pone.0057344

Éditeur(s) : HAL CCSD Elsevier
Résumé : revue électronique. consulter : http://religec.org/pdf/article%20Macdissi%20et%20al%202.pdf
L'existence et la persistance de disparités régionales en matière de chômage sont des problèmes communs à de nombreux pays européens. Dans ce papier, nous analysons les disparités des mécanismes d'ajustement des taux de chômage régionaux de la France à la suite de chocs économiques purement locaux ou nationaux. Les résultats mettent en évidence des disparités significatives dans les caractéristiques des mécanismes d'ajustement dynamiques (vitesse d'ajustement, effet multiplicateur) des taux de chômage régionaux en cas de choc macroéconomique national.
Revue Libanaise de Gestion et d'Economie

halshs-00433078
https://halshs.archives-ouvertes.fr/halshs-00433078
DOI : 10.1016/S1999-7620(09)70009-6

Éditeur(s) : HAL CCSD Elsevier
Résumé :  
Classifying species by shared life-history traits is important if common ecological response groups are to be identified among different species. We investigated how habitat area, local and regional factors shape plant communities in small isolated closed depressions, and how the species richness is related to the interplay between environmental factors and specific life-history trait combinations. In Central-Western Europe, 169 closed depressions were completely Surveyed for plant presence in two highly contrasted landscapes (forested and open landscapes). All species were clustered into 9 Emergent Groups based oil 10 life-history traits related to plant dispersal, establishment and persistence. Habitat areas were related to species presence using logistic regressions. Most Emergent Groups were more area-dependent in open than in forested landscapes, owing to heterogeneous light levels in forest weakening the species-area relationship. In open landscapes, Floating Hydrophytes were severely underrepresented in very small depressions, owing to the absence of waterfowl poulation. Local environmental and regional factors were related to species richness using Generalized Linear Models. In open landscapes, local environmental factors such as water conductivity or soil productivity are respectively the main predictors. In forested landscapes, the abundance of most Emergent Groups Was better predicted by regional factors, i.e., habitat connectivity and distance to the forest edge. Forested landscapes strongly impeded the closed depressions' colonization by the less mobile Emergent Groups Such as Large-seeded Perennials.
ISSN: 1146-609X

hal-01032144
https://hal.archives-ouvertes.fr/hal-01032144
DOI : 10.1016/j.actao.2009.02.002

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
ABSTRACT: Environmental exposures during pregnancy and early life may have adverse health effects. Single birth cohort studies often lack statistical power to tease out such effects reliably. To improve the use of existing data and to facilitate collaboration among these studies, an inventory of the environmental exposure and health data in these studies was made as part of the ENRIECO (Environmental Health Risks in European Birth Cohorts) project. The focus with regard to exposure was on outdoor air pollution, water contamination, allergens and biological organisms, metals, pesticides, smoking and second hand tobacco smoke (SHS), persistent organic pollutants (POPs), noise, radiation, and occupational exposures. The review lists methods and data on environmental exposures in 37 European birth cohort studies. Most data is currently available for smoking and SHS (N=37 cohorts), occupational exposures (N=33), outdoor air pollution, and allergens and microbial agents (N=27). Exposure modeling is increasingly used for long-term air pollution exposure assessment; biomonitoring is used for assessment of exposure to metals, POPs and other chemicals; and environmental monitoring for house dust mite exposure assessment. Collaborative analyses with data from several birth cohorts have already been performed successfully for outdoor air pollution, water contamination, allergens, biological contaminants, molds, POPs and SHS. Key success factors for collaborative analyses are common definitions of main exposure and health variables. Our review emphasizes that such common definitions need ideally be arrived at in the study design phase. However, careful comparison of methods used in existing studies also offers excellent opportunities for collaborative analyses. Investigators can use this review to evaluate the potential for future collaborative analyses with respect to data availability and methods used in the different cohorts and to identify potential partners for a specific research question.
ISSN: 1476-069X

inserm-00785248
http://www.hal.inserm.fr/inserm-00785248
http://www.hal.inserm.fr/inserm-00785248/document
http://www.hal.inserm.fr/inserm-00785248/file/1476-069X-12-8.pdf
DOI : 10.1186/1476-069X-12-8

Éditeur(s) : HAL CCSD Elsevier
Résumé : We present comparative field studies in folded areas (Southern France. Moroccan Western Atlas and Abruzzo, Italy) giving new insights into fracture distribution within folded rocks of the shallow brittle crust. We show that the curvature in folds formed in brittle mechanical units is usually accommodated by multiple "dip-domain boundaries" (appearing as curvature discontinuities at fold scale) corresponding to relatively narrow and dense fracture zones, striking parallel or slightly oblique to the fold axis. They separate "dip-domains" where curvature is absent or moderate. It is shown that the dip-domain boundaries (which are obvious in the case of kink folds or box-fold anticlines) are currently present as multiple subtle hinges even when the curvature appears continuous at first sight. The nature of dip-domain boundaries is studied, they often cut through the whole thickness of the mechanical units Their internal structure varies, and a non-exhaustive typology is proposed For each type, an interpretative kinematic scenario shows how the dip-domain boundaries could initiate and develop. We suggest two kinds of origins (1) they could correspond to the reactivation of inherited, along-strike fracture zones (opening-mode fracture concentrations such as big joints, fracture corridors. Inherited faults, etc), (2) they could be created as mechanical instabilities during the fold formation (syn-folding origin), in particular through small reverse faults. In both cases, early zones of weakness localize the dip-domain boundaries, and control the Increase in curvature in association with increasing fracture density within the boundary. Because they represent well-defined vertically and axially persistent sub-seismic fracture zones generally limited to the thickness of the folded unit, dip-domain boundaries could enhance the axial permeability of folded and fractured reservoirs.
ISSN: 0191-8141

hal-00512651
https://hal.archives-ouvertes.fr/hal-00512651
DOI : 10.1016/j.jsg.2010.03.002

Éditeur(s) : Institut Francais du Pétrole
Résumé : The study of the rock and sediment dredgings carried out on the Armorican margin between 47 and 48° latitude North enables us to precise this latter's paleogeographical and tectonic evolution and to integrate it to the Bay of Biscay's. The microfacies analysis of the rock samples dating back from the Upper Jurassic to the Neogene era demonstrates: - on the one hand, the belonging of the northern edge of the Armorican margin to the Mesogean domain, at least up to the Mid-Cretaceous period; - on the other hand, the persistence of a carbonated platform regime which seems to operate from the Tithonian to the lower Tertiary phase, and on which reef could grow, especially in the Mid-Cretaceous period. Over the whole period, sedimentation compensated for subsidence; - lastly, the increase of subsidence from the Eocene period (accompanied with a decrease in the calcium production?) which is most probably related to the major tectonic phenomena that affected the southern edge of the European plate at that time.
L'étude des dragages de roches et de sédiments effectués sur la marge armoricaine entre 47 et 48° de latitude Nord permet d'en préciser l'évolution paléogéographique et tectonique et de l'intégrer à celle du golfe de Gascogne. L'andyse de microfaciès des échantillons rocheux dont l'âge varie du Jurassique supérieur au Néogène met en évidence : - d'une part, l'appartenance de la bordure nord de la marge armoricaine au domaine mésogéen au moins jusqu'au Crétacé moyen ; - d'autre part, la permanence d'un régime de plate-forme carbonatée qui paraît fonctionner du Tithonique au Tertiaire inférieur, sur laquelle ont pu s'installer des édifices récifaux notamment au Crétacé moyen. Pendant toute cette période la sédimentation a compensé la subsidence ; - enfin, l'accentuation de la subsidence à partir de l'Éocène (accompagnée d'une diminution de la production de calcium ?) qui est vraisemblablement en relation avec les phénomènes tectoniques majeurs qui ont affecté à ce moment la bordure sud de la plaque européenne. [OCR NON CONTRÔLE]
Revue de l'Institut Francais du Pétrole (Institut Francais du Pétrole), 1976-06 , Vol. 31 , N. 3 , P. 401-425

Droits : Institut Francais du Pétrole
http://archimer.ifremer.fr/doc/1976/publication-5100.pdf
http://archimer.ifremer.fr/doc/00000/5100/

Éditeur(s) : HAL CCSD
Résumé : International audience
Some of the immunologic mechanisms involved in malaria physiopathology remain unclear. In animals, the spleen seems to play a key role in protecting the host against malaria. However, little is known about the effect of spleen dysfunction on human malaria. We report two severe cases of Plasmodium falciparum infection with unusual clinical and parasitologic features in two splenectomized men living in French Guiana. The peripheral blood of these cases showed hyperparasitemia, with a high proportion of mature parasites and leukocytes with malaria pigment. Despite appropriate treatment and adequate absorption, hyperparasitemia persisted. Parasite clearance was delayed and one patient died. Only the patient who died had the merozoite surface protein 1 allele B-K1 and the varD gene genotype, which is considered to be a probable parasite virulence factor. These uncommon cases differ from most of those described in the literature, illustrating the complexity of the mechanisms underlying the protective function of the spleen in human malaria.
The American journal of tropical medicine and hygiene

pasteur-00590993
https://hal-riip.archives-ouvertes.fr/pasteur-00590993
PUBMED : 15381808