Résumé : Le contrôle des pontes est primordial en aquaculture pour démarrer une filière pérenne. Il permet en premier lieu de ne plus dépendre des pontes naturelles dont les conditions de déclenchement sont mal connues pour la plupart des espèces. Le risque de se trouver, même pendant un temps relativement court, sans aucune production d’œufs peut mettre en danger la totalité de la filière. Pour Platax orbicularis (Paraha peue en polynésien) il a été intéressant de comparer deux méthodes d’induction de la ponte. La dessalure semble présenter de nombreux avantages face à l’injection. Sa facilité de mise en œuvre, le niveau limité de stress qu’elle provoque, la meilleure qualité possible des pontes induites, l’administration d’un traitement anti-parasitaire simultané et son caractère éthique et éco-responsable sont autant d’arguments en sa faveur. L’injection semble un moyen plus robuste de stimulation (au départ) car les deux femelles n’ont répondu qu’à la stimulation hormonale et jamais aux dessalures. Ainsi une bonne connaissance des deux méthodes de stimulation est importante pour une gestion durable des reproducteurs et de toute la filière du Platax orbicularis.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00128/23876/21811.pdf
http://archimer.ifremer.fr/doc/00128/23876/

Éditeur(s) : HAL CCSD
Résumé : International audience
The identification and economic valuation of ecosystem services (ES) are becoming important components of coral reef management. In many contexts, protection of human assets against coastal floods is one of the most important ES provided by coral reefs. The methods utilized to characterize this ES should be able to accommodate situations with low data availability, without sacrificing robustness. In this paper, we suggest such an approach that utilizes expert opinion and does not require copious amounts of data. Our primary objective is to find a balance between simple and complex models that can be used in a data scarce environment, to produce an economic valuation of the coral reef ES of protection against coastal floods. The approach has three steps: (i) identify geographic zones and assets at risk, (ii) identify the contributing role of coral reefs in the protection of coasts and, (iii) value the annual repair costs of assets through the avoided damage cost approach. The proposed method seems appropriate for advocacy with policy makers, but appears to be less effective for small scale approaches, such as those required for Payment for ES negotiations or marine spatial planning.
Ecosystem Services

hal-01359394
https://hal-univ-perp.archives-ouvertes.fr/hal-01359394
DOI : 10.1016/j.ecoser.2016.07.005

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores that epigenetic memories are in fact more robustly ensured in living systems by steady-state mechanisms with permanent molecule renewal. This misconception is likely to result from misleading intuitions and insufficient dialogues between traditional and quantitative biologists. To demystify dynamic epigenetics, its most famous image, a Waddington landscape and its attractors, are explicitly drawn. The simple example provided, is sufficient to highlight the main requirements and characteristics of dynamic gene networks, underlying cellular differentiation, de-differentiation and trans-differentiation.
ISSN: 0248-4900

inserm-00920766
http://www.hal.inserm.fr/inserm-00920766
http://www.hal.inserm.fr/inserm-00920766/document
http://www.hal.inserm.fr/inserm-00920766/file/Dynamic_Epigenetics.pdf
PUBMED : 24111561

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study provides an integrated review of plate tectonic models of the evolution of the Antarctica-Patagonia connection compared to geological records collected on land in Patagonia and Tierra del Fuego, and offshore along the northern edge of the Scotia Sea. A temporal framework for the sedimentary and tectonic events of the North Scotia Ridge and Tierra del Fuego is constructed with additional data compiled from entire Patagonia and the Austral Basin. This review provides robust correlations of seaways and tectonic events along the Scotia and South America plates and indicates that the opening of the Drake Passage was not steady state since ca. 30 Ma. Rather the regions forming the present-day northern limit of this gateway experienced important paleogeographic changes, from deep marine basins to shallow ridges and emerged regions during the late Oligocene and early-middle Miocene time. Our compilation of geological data shows that emergence along the North Scotia Ridge and Tierra del Fuego was achieved at 23-22 Ma, and has been followed by elimination of the Patagoniano Sea in Patagonia, starting at 22-23 Ma and achieved at 20 Ma. This transition towards more continental sedimentation in southern South America is correlated with more shallow marine conditions in the Austral Basin. This succession of events had a strong influence on the general geometry of the Drake Passage, corresponding to a constriction of its northern limit, starting in the window 29-22 Ma and achieved at 21 Ma. This period of active deformation in southern South America also corresponds to a period of the global climate having two anomalies well known from the isotopic records: the Late Oligocene Warming. around 26 Ma and the Mid-Miocene Climatic Optimum which ended between 15 and 14 Ma. The possible effects of the post-Oligocene tectonic evolution of the Drake Passage region on general oceanic circulation are discussed. Causes for the synchronicity between tectonic events and these global warming events are examined.
ISSN: 0012-821X

hal-00413525
https://hal.archives-ouvertes.fr/hal-00413525
DOI : 10.1016/j.epsl.2008.12.037

Éditeur(s) : HAL CCSD Geological Society of London
Résumé : Permo-Triassic rift basins offer important hydrocarbon targets along the Atlantic margins. Their fill is dominated by continental red beds, comprising braided fluvial, alluvial fan, aeolian, floodplain and lacustrine facies. These relatively lightly explored basins span both the Atlantic and Tethyan domains and developed above a complex basement with inherited structural fabrics. Sparse data in offshore regions constrain understanding of depositional geometries and sedimentary architecture, further impeded by their deep burial beneath younger strata, combined with the effects of later deformation during continental breakup. This paper provides results from a multidisciplinary analysis of basins along the Atlantic margin. Regional seismic and well data, combined with geochemical provenance analysis from the European North Atlantic margins, are integrated with detailed outcrop studies in Morocco and Nova Scotia. The research provides new insights into regional basin tectonostratigraphic evolution, sediment fill, and reservoir distribution, architecture and quality at a range of scales. Regional seismic profiles, supported by key well data, indicate the presence of post-orogenic collapse basins, focused narrow rifts and low-magnitude multiple extensional depocentres. Significantly, Permo-Triassic basin geometries are different and more varied than the overlying Jurassic and younger basins. Provenance analysis using Pb isotopic composition of detrital K-feldspar yields new and robust controls on the sediment dispersal patterns of Triassic sandstones in the NE Atlantic margin. The evolving sedimentary architecture is characterized by detailed sedimentological studies of key outcrops of age equivalent Permian-Triassic rifts in Morocco and Nova Scotia. The interplay of tectonics and climate is observed to influence sedimentation, which has significant implications for reservoir distribution in analogue basins. New digital outcrop techniques are providing improved reservoir models, and identification of key marker horizons and sequence boundaries offers a potential subsurface correlation tool. Future work will address source and seal distribution within the potentially petroliferous basins.
Petroleum Geology: From Mature Basins to New Frontiers Proceedings of the 7th Petroleum Geology Conf

hal-00590618
https://hal.archives-ouvertes.fr/hal-00590618

Éditeur(s) : HAL CCSD Wiley/Blackwell
Résumé : Whole genome sequencing is helping generate robust phylogenetic hypotheses for a range of taxonomic groups that were previously recalcitrant to classical molecular phylogenetic approaches. As a case study, we performed a shallow shotgun sequencing of eight species in the tropical tree family Chrysobalanaceae to retrieve large fragments of high-copy number DNA regions and test the potential of these regions for phylogeny reconstruction. We were able to assemble the nuclear ribosomal cluster (nrDNA), the complete plastid genome (ptDNA) and a large fraction of the mitochondrial genome (mtDNA) with approximately 1000x, 450x and 120x sequencing depth respectively. The phylogenetic tree obtained with ptDNA resolved five of the seven internal nodes. In contrast, the tree obtained with mtDNA and nrDNA data were largely unresolved. This study demonstrates that genome skimming is a cost-effective approach and shows potential in plant molecular systematics within Chrysobalanaceae and other under-studied groups.
ISSN: 1755-098X

hal-01204217
https://hal.archives-ouvertes.fr/hal-01204217
DOI : 10.1111/1755-0998.12246
PRODINRA : 283530

Éditeur(s) : HAL CCSD American Association for Cancer Research
Résumé : International audience
Homing of CD8+ T lymphocytes to the tumor microenvironment is an important step for mounting a robust antitumor immune response. TGF-β is responsible for CD103 (αEβ7) integrin induction in activated intraepithelial CD8+ T lymphocytes. However, the interplay between TGF-β and CD103 and their contribution to T-cell infiltration and antitumor activity remain unknown. Here, we used viable human lung tumor slices and autologous tumor antigen-specific T-lymphocyte clones to provide evidence that CD103 is directly involved in T-lymphocyte recruitment within epithelial tumor islets and intratumoral early T-cell signaling. Moreover, TGF-β enhanced CD103-dependent T-cell adhesion and signaling, whereas it inhibited leukocyte function-associated antigen (LFA)-1 (αLβ2) integrin expression and LFA-1-mediated T-lymphocyte functions. Mechanistic investigations revealed that TGF-β bound to its receptors (TGFBR), which promoted the recruitment and phosphorylation of integrin-linked kinase (ILK) by TGFBR1. We further show that ILK interacted with the CD103 intracellular domain, resulting in protein kinase B (PKB)/AKT activation thereby initiating integrin inside-out signaling. Collectively, our findings suggest that the abundance of TGF-β in the tumor microenvironment may in fact engage with integrin signaling pathways to promote T-lymphocyte antitumor functions, with potential implications for T-cell-based immunotherapies for cancer
ISSN: 0008-5472

Droits : info:eu-repo/semantics/OpenAccess
hal-01282442
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282442
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282442/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282442/file/TGF%CE%B2%20Signaling%20Intersects%20with%20CD103-boutet2016-final.pdf
DOI : 10.1158/0008-5472.CAN-15-1545

Éditeur(s) : HAL CCSD Springer Verlag (Germany) Springer Verlag
Résumé : International audience
We have investigated the partitioning of Fe3+ between orthopyroxene (Opx) and garnet (Grt) in well-equilibrated mantle xenoliths using Mössbauer spectroscopy. The samples cover a wide range of P–T conditions (2.1–6.6 GPa, 690–1,412 °C) and geothermal gradients, and are thus representative for Earth’s upper mantle in both on-craton and off-craton continental settings. Garnet has Fe3+/Fetot ratios of 0.03–0.13 and Fe2O3 contents of 0.24–1.00 wt%. Orthopyroxene has, on average, lower Fe3+/Fetot ratios (0.01–0.09) and Fe2O3 contents (0.05–0.63 wt%). In low-pressure, high-temperature samples, however, Opx is systematically richer in Fe2O3 than the coexisting Grt. The Fe3+ Opx/Grt partition coefficient (DOpx/GrtFe3+) shows no obvious relationship with temperature, but increases with decreasing pressure and with increasing NaOpx. The observed Opx/Grt Fe3+ systematics imply that the Opx–Grt Fe–Mg exchange thermometer is not robust against redox changes if total Fe is treated as Fe2+. An approximate evaluation of errors on T estimates due to redox effects predicts negligible deviations for strongly reduced conditions (<65 °C), but potentially large deviations (> to ≫100 °C) for strongly oxidized conditions, especially at very high pressure and when both P and T are calculated by iteration.
ISSN: 0010-7999

hal-01121606
https://hal.archives-ouvertes.fr/hal-01121606
DOI : 10.1007/s00410-014-1101-8

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Mesoporous cobalt oxide silica matrices and membranes were successfully prepared using a dual acid-base catalysed sol-gel and interlayer-free approach for desalination applications. The effects of cobalt addition (0-35 mol%) on the structure-property relationship of the silica materials and membrane performance were systematically studied as a function of feed salt concentration (0.3-7.5 wt.% NaCl) and temperature (22-60 °C). As cobalt concentration increases beyond 5 mol%, the concentration of tricobalt tetroxide and proportion of silica mesopores were found to increase within the matrices. Silica membranes with high amount of tricobalt tetroxide (35 mol%) were found to be highly mesoporous with water fluxes of 20, 11.3 and 7.7 kg m-2 h-1 for the 0.3, 3.5 and 7.5 wt.% solutions at 60 °C, respectively, with >99.7% salt rejection at all times. This is attributed to the high pore volume (mesopores formation) and structural robustness of the silica network provided by the presence of tricobalt tetroxide. Even higher performance was achieved for low tricobalt tetroxide (mol%) silica membranes with water fluxes of 47.6 (0.3 wt.%) and 31.5 (3.5 wt.%) kg m-2 h-1 at 60 °C, respectively, though with reduced salt rejections of 90%. © 2015 Elsevier B.V.
ISSN: 0011-9164

hal-01683209
https://hal.univ-antilles.fr/hal-01683209
DOI : 10.1016/j.desal.2015.02.034

Éditeur(s) : HAL CCSD
Résumé : International audience
Vulnerability–resilience indexes fail to grasp all dimensions of sustainability, whereas sustainable development has gained momentum. We fill this gap with a hierarchical multimetric composite index (Net Vulnerability Resilience Index: NVRI) whose robustness relies on a mathematical algorithm based on graph theory. A worldwide application shows that (i) both vulnerability and resilience are policy-responsive and that (ii) there is no determinism for a country to remain vulnerable or resilient. The NVRI enables us to identify a country’s strengths and weaknesses and determine the policy orientations that should be implemented to achieve sustainability.
World Development

hal-01291345
https://hal.archives-ouvertes.fr/hal-01291345
DOI : 10.1016/j.worlddev.2015.02.011

Éditeur(s) : HAL CCSD
Résumé : In SW Yukon – SE Alaska, the boundary between the Pacific and North America plates is characterized by a syntaxis at the transition between the Aleutian subduction to the W and the Fairweather – Queen Charlotte strike-slip faults to the SE. The relative motion is oblique to the main fault structures, and the area is marked by the Yakutat block collision. From the Chugach – Saint Elias mountains in the plate boundary zone (up to 6 000 m high) to the intraplate strike-slip faults, markers of the present-day deformation give information on its partition in the system.During my PhD, I first measure surface deformation using a dense GPS network, deployed up to 500 km inland the North America plate. After precise processing and corrections of transient effects in the area (postseismic and glacial isostatic rebound), a new residual velocity field is produced for the syntaxis area, from which I derive strain rates. Those data allow me to quantify the fault slip rates for Fairweather and southern Denali strike-slip faults, and to characterize a bi-modal deformation pattern: Along the plate boundary, the deformation is localized on large-scale structures (accretionary prism to the W, Fairweather to the E); In the syntaxis area, strain rates are the highest and the GPS data shows a diffuse intraplate deformation, similar to an indentor pattern. The Yakutat block seems to strongly drive the North America plate deformation.This indentor pattern induces strong lateral variations on the large intraplate faults: the Denali – Totschunda – Duke River system. In a second part, I realize a regional geomorphological study to characterize the role and slip rate of those faults. From very high-resolution Digital Elevation Models (~ 1 m), a detailed cartography is done. On the basis of fieldwork observations, I measure offsets of fluvial and glacial markers, which are sampled for dating. A dextral cumulative deformation is highlighted on the northern Denali Fault, where as all southern Denali is marked by vertical deformation. This study allows me to quantify new slip rates for the system Denali – Totschunda – Duke River, and to show the leading role of the Totschunda (~ 14 mm/a) and Duke River (~ 6 mm/a) faults, contrary to the Denali Fault (~ 1 mm/a) North of the syntaxis.The new tectonic model for the Yakutat collision provides an important case study for the understanding of indentor systems. The concomitance of a rigid-block deformation (to the West) and diffuse deformation (to the East), as well as the near-zero slip rate on the lithospheric-scale southern Denali Fault highlight the major control of boundary conditions and the structural heritage on the orogen deformation.
Au SO Yukon – SE Alaska, la frontière entre les plaques Pacifique et Nord-Amérique est marquée par une syntaxe à la transition entre la subduction des Aléoutiennes à l’O et le décrochement de Fairweather – Queen Charlotte au SE. Le mouvement relatif est oblique et la région est marquée par la collision du bloc Yakutat. De la chaine des Chugach – Saint Elias en frontière de plaque (jusqu’à 6 000 m d’altitude) aux grands décrochements intraplaque, les marqueurs de la déformation actuelle apportent des informations sur sa partition dans ce système.Au cours de cette thèse, je m’intéresse dans un premier temps à mesurer la déformation de surface à l’aide d’un réseau GPS dense, déployé jusqu’à 500 km à l’intérieur de la plaque Nord-Amérique. Après un travail minutieux de traitement des données et de correction des effets transitoires (rebond post-glaciaire et post-sismique), un champ de vitesses résiduelles robuste et inédit est produit au niveau de la syntaxe, dont je dérive des taux de déformation. Ces données me permettent de quantifier les vitesses de glissement les failles décrochantes de Fairweather et Denali au Sud, et également de caractériser une déformation bimodale : En frontière de plaques, la déformation est localisée sur les grandes structures (prisme d’accrétion à l’O, Fairweather à l’E) ; Au niveau de la syntaxe, les taux de déformation sont les plus importants et les données GPS mettent en évidence une déformation intraplaque diffuse, similaire à un champ attendu à l’aplomb d’un indenteur. Le bloc Yakutat semble donc contrôler fortement la déformation de la plaque Nord-Amérique.Ce champ de déformation induit des variations latérales fortes sur les grandes failles intraplaque : le système Denali-Totschunda-Duke River. Dans une seconde partie, je réalise une étude géomorphologique régionale pour caractériser le rôle et la vitesse de ces failles. À partir de Modèles Numériques de Terrain très haute résolution (~ 1 m), une cartographie de détail est réalisée. Puis une mission de terrain me permet de mesurer des décalages sur des marqueurs fluviatiles et glaciaires et collecter des échantillons pour les dater. Je mets en évidence une déformation cumulée dextre sur le segment Nord de la faille de Denali, alors que toute la partie Sud déforme verticalement la surface. Cette étude me permet de quantifier de nouvelles vitesses de failles sur le système Denali-Totschunda-Duke River, et de montrer le rôle prépondérant des failles de Totschunda (~ 14 mm/a) et Duke River (~ 6 mm/a) contrairement à la faille de Denali (~ 1 mm/a) au Nord de la syntaxe.Le nouveau modèle cinématique proposé pour la région de collision Yakutat permet d’apporter un nouvel exemple à la compréhension des systèmes d’indenteur. La concomitance d’une déformation de blocs (à l’Ouest) et diffuse (à l’Est), ainsi que l’absence de déformation sur la faille lithosphérique de Denali Sud met en évidence le contrôle majeur des conditions aux limites et de l’héritage structural dans la déformation des orogènes.
https://hal.archives-ouvertes.fr/tel-01241688

tel-01241688
https://hal.archives-ouvertes.fr/tel-01241688
https://hal.archives-ouvertes.fr/tel-01241688/document
https://hal.archives-ouvertes.fr/tel-01241688/file/manuscrit_anais_v2_optimise.pdf

Éditeur(s) : Public Library Science
Résumé : Where conservation resources are limited and conservation targets are diverse, robust yet flexible priority-setting frameworks are vital. Priority-setting is especially important for geographically widespread species with distinct populations subject to multiple threats that operate on different spatial and temporal scales. Marine turtles are widely distributed and exhibit intra-specific variations in population sizes and trends, as well as reproduction and morphology. However, current global extinction risk assessment frameworks do not assess conservation status of spatially and biologically distinct marine turtle Regional Management Units (RMUs), and thus do not capture variations in population trends, impacts of threats, or necessary conservation actions across individual populations. To address this issue, we developed a new assessment framework that allowed us to evaluate, compare and organize marine turtle RMUs according to status and threats criteria. Because conservation priorities can vary widely (i.e. from avoiding imminent extinction to maintaining long-term monitoring efforts) we developed a "conservation priorities portfolio" system using categories of paired risk and threats scores for all RMUs (n = 58). We performed these assessments and rankings globally, by species, by ocean basin, and by recognized geopolitical bodies to identify patterns in risk, threats, and data gaps at different scales. This process resulted in characterization of risk and threats to all marine turtle RMUs, including identification of the world's 11 most endangered marine turtle RMUs based on highest risk and threats scores. This system also highlighted important gaps in available information that is crucial for accurate conservation assessments. Overall, this priority-setting framework can provide guidance for research and conservation priorities at multiple relevant scales, and should serve as a model for conservation status assessments and priority-setting for widespread, long-lived taxa.
Plos One (1932-6203) (Public Library Science), 2011-09 , Vol. 6 , N. 9 , P. 1-14

Droits : 2011 Wallace et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License
http://archimer.ifremer.fr/doc/00050/16097/13573.pdf
DOI:10.1371/journal.pone.0024510
http://archimer.ifremer.fr/doc/00050/16097/

Éditeur(s) : HAL CCSD Springer
Résumé : Third International Workshop, MLMI 2012, Held in Conjunction with MICCAI 2012
International audience
Universal Nearest Neighbours (unn) is a classifier recently proposed, which can also effectively estimates the posterior probability of each classification act. This algorithm, intrinsically binary, requires the use of a decomposition method to cope with multiclass problems, thus reducing their complexity in less complex binary subtasks. Then, a reconstruction rule provides the final classification. In this paper we show that the application of unn algorithm in conjunction with a reconstruction rule based on the posterior probabilities provides a classification scheme robust among different biomedical image datasets. To this aim, we compare unn performance with those achieved by Support Vector Machine with two different kernels and by a k Nearest Neighbours classifier, and applying two different reconstruction rules for each of the aforementioned classification paradigms. The results on one private and five public biomedical datasets show satisfactory performance.
Machine Learning in Medical Imaging
Nice, France

hal-00958909
https://hal.archives-ouvertes.fr/hal-00958909
https://hal.archives-ouvertes.fr/hal-00958909/document
https://hal.archives-ouvertes.fr/hal-00958909/file/Miccai.pdf
DOI : 10.1007/978-3-642-35428-1_15

Éditeur(s) : HAL CCSD
Résumé : International audience
The method we propose is a new approach to the problem of extbf{satellite constellation design}. The main difficulties of this field are the size of the solution space, the computation time of the optimization criterion and the lack of information to analyse and improve a solution. Our model bypasses some of these obstacles by using an extbf{inverse approach} where services to be fulfilled are highlighted. The algorithm is composed of different layers solving different problems. We first use the specifications of the services to compensate for lack of information returned by the criterion to analyse and improve a solution. An orbit database introduces an expert knowledge linked to a robust estimator to set consistent orbital parameters. We use a partial evaluation of the constellation to reduce the criterion computation time. The highest level of the algorithm is a metaheuristic layer that drives the search across the wide solution space with a probabilistic tabu search.
ICAI Proceeding

hal-00634752
https://hal.archives-ouvertes.fr/hal-00634752

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : Traditional measures of diversity, namely the number of species as well as Simpson's and Shannon's indices, are particular cases of Tsallis entropy. Entropy decomposition, i.e. decomposing gamma entropy into alpha and beta components, has been previously derived in the literature. We propose a generalization of the additive decomposition of Shannon entropy applied to Tsallis entropy. We obtain a self-contained definition of beta entropy as the information gain brought by the knowledge of each community composition. We propose a correction of the estimation bias allowing to estimate alpha, beta and gamma entropy from the data and eventually convert them into true diversity. We advocate additive decomposition in complement of multiplicative partitioning to allow robust estimation of biodiversity.
ISSN: 1932-6203

hal-01189953
https://hal.archives-ouvertes.fr/hal-01189953
DOI : 10.1371/journal.pone.0090289
PRODINRA : 259795
PUBMED : 24603966

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
BACKGROUND: People in developed countries are widely exposed to low levels of organochlorine pesticides, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs). Seafood is a major contributor to PCB exposure. Toxicity of those various pollutants to reproductive and endocrine functions raises questions about possible effects on fertility. We explored whether serum levels of these pollutants and seafood consumption were associated with the fertility of couples enrolled in a French birth cohort (PELAGIE). METHODS: Time-to-pregnancy was investigated in 3,421 pregnant women by asking how many months they had taken to conceive. Levels of 14 organochlorine pesticides, 12 PCBs, and 10 PBDE compounds were measured in cord blood serum from a random subcohort (n = 394). Mercury concentrations measured in maternal hair were considered as a potential coexposure. Fecundability odds ratios (ORs) were estimated from multivariate discrete-time Cox proportional hazard models. RESULTS: Shellfish consumption was associated with longer time-to-pregnancy (fecundability OR ≥twice/week vs. 0.410 µg/L vs. <0.266 µg/L, fecundability OR = 0.46 [0.32-0.66]). In multiple sensitivity analyses, reduced fecundability was most consistently associated with shellfish consumption, p,p'-DDE, total PCBs, PCB153, and PCB187. Models that simultaneously included multiple coexposure factors led to similar conclusions. CONCLUSIONS: Our findings were robust in sensitivity analyses, including analysis restricted to primiparous women. These results suggest that PCBs, p,p'-DDE, and other shellfish contaminants may impair human fertility.
ISSN: 1044-3983

inserm-00826533
http://www.hal.inserm.fr/inserm-00826533
DOI : 10.1097/EDE.0b013e31827f53ec
PUBMED : 23348067

Éditeur(s) : Elsevier
Résumé : Choice of sampling method and survey period can have an important impact on the perception of the structure and dynamics of an ecological community. For the Celtic Sea fish assemblage we compared data obtained by three different trawl surveys: an autumn groundfish survey with a GOV trawl, and a spring and an autumn groundfish survey, both carried out with a Portuguese high-headline trawl. Time-series of abundance estimates were not consistent among surveys for all species and were generally very noisy. An analysis of variance components showed that the sampling method contributed more to the variance in abundance estimates compared to survey period, interannual variability, or even sampling variance. Overall community assessments based on indicators such as proportions of non-commercial and piscivorous species, and the proportion of benthic species showed similar trends for all data series. The shape of the size spectrum based on abundances per length class summed over all fish species, although stable over time, was highly sensitive to the sampling method. With the exception of size spectra, community indicators for marine fish assemblages monitored by surveys seem to be robust to survey period and trawling gear, but species abundance trends are method dependent.
ICES Journal of Marine Science (1054-3139) (Elsevier), 2004-05 , Vol. 61 , N. 3 , P. 351-362

Droits : 2004 International Council for the Exploration of the Sea. Published by Elsevier Science Ltd
http://archimer.ifremer.fr/doc/2004/publication-899.pdf
DOI:10.1016/j.icesjms.2004.01.004
http://archimer.ifremer.fr/doc/00000/899/

Éditeur(s) : HAL CCSD Cambridge University Press (CUP)
Résumé : A specific breeding goal definition was developed for Creole goats in Guadeloupe. This local breed is used for meat production. To ensure a balanced selection outcome, the breeding objective included two production traits, live weight (BW11) and dressing percentage (DP) at 11 months (the mating or selling age), one reproduction trait, fertility (FER), and two traits to assess animal response to parasite infection: packed cell volume (PCV), a resilience trait, and faecal worm eggs count (FEC), a resistance trait. A deterministic bio-economic model was developed to calculate the economic values based on the description of the profit of a Guadeloupean goat farm. The farm income came from the sale of animals for meat or as reproducers. The main costs were feeding and treatments against gastro-intestinal parasites. The economic values were 7.69€ per kg for BW11, 1.38€ per % for FER, 3.53€ per % for DP and 3 × 10(-4)€ per % for PCV. The economic value for FEC was derived by comparing the expected profit and average FEC in a normal situation and in an extreme situation where parasites had developed resistance to anthelmintics. This method yielded a maximum weighting for FEC, which was -18.85€ per log(eggs per gram). Alternative scenarios were tested to assess the robustness of the economic values to variations in the economic and environmental context. The economic values of PCV and DP were the most stable. Issues involved in paving the way for selective breeding on resistance or resilience to parasites are discussed.
ISSN: 1751-7311

hal-01000063
https://hal.archives-ouvertes.fr/hal-01000063
DOI : 10.1017/S1751731112001413
PUBMED : 23031546

Éditeur(s) : HAL CCSD Institute for Scientific Computing and Information
Résumé : International audience
In this paper, we solve a problem describing the mechanical deformations of a porous medium in the presence of a monophasic linear flow or a two phase nonlinear flow with the purpose of modelizing subsidence of hydrocarbon reservoirs. An essential characteristics of this problem is that the mechanical deformation and the flow have different time scales. In petroleum industry, one uses different very efficient simulators for the flow problem and the mechanical deformations, which enables to handle complex models. Therefore it is necessary to be able to combine as efficiently as possible the exploitation of these simulators. We propose two alternative splitting approaches. The first one is the staggered algorithm used by engineers, which amounts to a Gauss-Seidel method in the one phase linear case. The second approach is based upon the preconditioned conjugate gradient method. We use a numerical multi-scale method in both of these algorithms. We compare these two approaches and we show that the preconditioned conjugate gradient algorithm is faster and more robust than the staggered algorithm. Applying the preconditioned conjugate gradient algorithm therefore seems to compensate for the fact that the inf-sup condition for the mixed discretization method is not satisfied when combining the simulators for the mechanical deformations and for the flow computations.
ISSN: 1705-5105

Droits : http://creativecommons.org/licenses/by/
hal-01449039
https://hal.archives-ouvertes.fr/hal-01449039
https://hal.archives-ouvertes.fr/hal-01449039/document
https://hal.archives-ouvertes.fr/hal-01449039/file/DHLE.pdf

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
The natural history of pulmonary Langerhans cell histiocytosis (PLCH) has been unclear due to the absence of prospective studies. The rate of patients who experience an early progression of their disease is unknown. Additionally, conflicting effects of smoking cessation on the outcome of PLCH have been reported. In this prospective, multicentre study, 58 consecutive patients with newly diagnosed PLCH were comprehensively evaluated over a two-year period. Our objectives were to estimate the incidence of early progression of the disease and to evaluate the impact of smoking status on lung function outcomes. Lung function deterioration was defined as a decrease of at least 15% in FEV1 and/or FVC and/or DLCO, compared with baseline values. At each visit, smoking status was recorded based on the patients' self-reports and urinary cotinine measurements that were blinded for the patients. The cumulative incidence of lung function outcomes over time was estimated using the non-parametric Kaplan-Meier method. Multivariate Cox models with time-dependent covariates were used to calculate the hazards ratios of the lung function deterioration associated with smoking status with adjustment for potential confounders. The cumulative incidence of lung function deterioration at 24 months was 38% (22% for FEV1 and DLCO, and 9% for FVC). In the multivariate analysis, smoking status and PaO2 at inclusion were the only factors associated with the risk of lung function deterioration. The patients' smoking statuses markedly changed over time. Only 20% of the patients quit using tobacco for the entire study period. Nevertheless, being a non-smoker was associated with a decreased risk of subsequent lung function deterioration, even after adjustment for baseline predictive factors. By serial lung computed tomography, the extent of cystic lesions increased in only 11% of patients. Serial lung function evaluation on a three- to six-month basis is essential for the follow-up of patients with recently diagnosed PLCH to identify those who experience an early progression of their disease. These patients are highly addicted to tobacco, and robust efforts should be undertaken to include them in smoking cessation programs. ClinicalTrials.gov: No: NCT01225601 .
ISSN: 1750-1172

hal-01146047
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146047
PUBMED : 25887097
DOI : 10.1186/s13023-015-0249-2