Éditeur(s) : HAL CCSD Oxford University Press (OUP): Policy B - Oxford Open Option A
Résumé :  
The mechanism for tree orientation in angiosperms is based on the production of high tensile stress on the upper side of the inclined axis. In many species, the stress level is strongly related to the presence of a peculiar layer, called the G-layer, in the fibre cell wall. The structure of the G-layer has recently been described as a hydrogel thanks to N2 adsorption-desorption isotherms of supercritically dried samples showing a high mesoporosity (pores size from 2-50 nm). This led us to revisit the concept of the G-layer that had been, until now, only described from anatomical observation. Adsorption isotherms of both normal wood and tension wood have been measured on six tropical species. Measurements show that mesoporosity is high in tension wood with a typical thick G-layer while it is much less with a thinner G-layer, sometimes no more than normal wood. The mesoporosity of tension wood species without a G-layer is as low as in normal wood. Not depending on the amount of pores, the pore size distribution is always centred around 6-12 nm. These results suggest that, among species producing fibres with a G-layer, large structural differences of the G-layer exist between species.
Journal of Experimental Botany

hal-01032161
https://hal.archives-ouvertes.fr/hal-01032161
DOI : 10.1093/jxb/erp133

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
It was recently reported that the sizes of many mRNAs change when budding yeast cells exit mitosis and enter the meiotic differentiation pathway. These differences were attributed to length variations of their untranslated regions. The function of UTRs in protein translation is well established. However, the mechanism controlling the expression of distinct transcript isoforms during mitotic growth and meiotic development is unknown. In this study, we order developmentally regulated transcript isoforms according to their expression at specific stages during meiosis and gametogenesis, as compared to vegetative growth and starvation. We employ regulatory motif prediction, in vivo protein-DNA binding assays, genetic analyses and monitoring of epigenetic amino acid modification patterns to identify a novel role for Rpd3 and Ume6, two components of a histone deacetylase complex already known to repress early meiosis-specific genes in dividing cells, in mitotic repression of meiosis-specific transcript isoforms. Our findings classify developmental stage-specific early, middle and late meiotic transcript isoforms, and they point to a novel HDAC-dependent control mechanism for flexible transcript architecture during cell growth and differentiation. Since Rpd3 is highly conserved and ubiquitously expressed in many tissues, our results are likely relevant for development and disease in higher eukaryotes.
ISSN: 0305-1048

Droits : http://creativecommons.org/licenses/by/
hal-01122128
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122128
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122128/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122128/file/The%20conserved%20histone%20deacetylase.pdf
DOI : 10.1093/nar/gku1185

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide a unified interface to biomedical databases that are distributed worldwide. The portal provides access to numerous database projects supported by 30 scientific organizations. It includes over 800 different biological datasets spanning genomics, proteomics, model organisms, cancer data, ontology information and more. All resources available through the portal are independently administered and funded by their host organizations. The BioMart data federation technology provides a unified interface to all the available data. The latest version of the portal comes with many new databases that have been created by our ever-growing community. It also comes with better support and extensibility for data analysis and visualization tools. A new addition to our toolbox, the enrichment analysis tool is now accessible through graphical and web service interface. The BioMart community portal averages over one million requests per day. Building on this level of service and the wealth of information that has become available, the BioMart Community Portal has introduced a new, more scalable and cheaper alternative to the large data stores maintained by specialized organizations.
ISSN: 0305-1048

hal-01146849
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146849
DOI : 10.1093/nar/gkv350
PUBMED : 25897122

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : This paper presents an inversion method using the interseismic velocity field to determine effective rigidity of the lithosphere. The method is based on the minimization of a cost function defined as the quadratic measure of the difference between measured and modelled velocity fields on a discrete set of points. The continuous mapping of the rigidity is fulfilled with a limited set of parameters and the forward solution is achieved using a plane stress finite element code. The computation of the cost function gradient in the parameters' space allows one to iteratively find the best parameters set through a suitable optimization algorithm.;We first design a benchmark including an abrupt rigidity variation that cannot be described by a continuous function. For such a case, we show that increasing the number of parameters is a way to accurately describe sharp variations of the rigidity map. Then, we use a dense GPS velocity field over the southwestern United States to estimate the corresponding rigidity variations for different spatial resolutions of the parameters' grid. We analyse the conceptual and practical difficulties associated with our methodology. Finally, rigidity maps obtained by our inversion method in southwestern United States and particularly across the San Andreas Fault System are reviewed and compared to current plate rigidity estimates and geophysical data over this area.
ISSN: 0956-540X

hal-00669897
https://hal.archives-ouvertes.fr/hal-00669897
DOI : 10.1111/j.1365-246X.2011.05192.x

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
The mechanism for tree orientation in angiosperms is based on the production of high tensile stress on the upper side of the inclined axis. In many species, the stress level is strongly related to the presence of a peculiar layer, called G-layer, in the fibre wall. The structure of G-layer has been recently described as a hydrogel thanks to N2 adsorption-desorption isotherms of supercritically dried samples showing a high mesoporosity (pores size from 2 to 50 nm). This led us to revisit the concept of G-layer that was until now only described from anatomical observation. Adsorption isotherms of both normal wood and tension wood have been measured on six tropical species. Measurements show that mesoporosity is high in tension wood with typical thick G-layer while it is much less with thinner G-layer, sometimes no more than normal wood. The mesoporosity of tension wood species without G-layer is as low as in normal wood. Not depending on the amount of pores, the pore sizes distribution are always centred around 6-12 nm. These results suggest that, among species producing fibres with G-layer, large structural differences of G-layer exist between species
ISSN: 0022-0957

hal-00387861
https://hal.archives-ouvertes.fr/hal-00387861
DOI : 10.1093/jxp/erp133

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : In habitat mosaics, plant populations face environmental heterogeneity over short geographical distances. Such steep environmental gradients can induce ecological divergence. Lowland rainforests of the Guiana Shield are characterized by sharp, short-distance environmental variations related to topography and soil characteristics (from waterlogged bottomlands on hydromorphic soils to well-drained terra firme on ferralitic soils). Continuous plant populations distributed along such gradients are an interesting system to study intrapopulation divergence at highly local scales. This study tested (1) whether conspecific populations growing in different habitats diverge at functional traits, and (2) whether they diverge in the same way as congeneric species having different habitat preferences. Phenotypic differentiation was studied within continuous populations occupying different habitats for two congeneric, sympatric, and ecologically divergent tree species (Eperua falcata and E. grandiflora, Fabaceae). Over 3000 seeds collected from three habitats were germinated and grown in a common garden experiment, and 23 morphological, biomass, resource allocation and physiological traits were measured. In both species, seedling populations native of different habitats displayed phenotypic divergence for several traits (including seedling growth, biomass allocation, leaf chemistry, photosynthesis and carbon isotope composition). This may occur through heritable genetic variation or other maternally inherited effects. For a sub-set of traits, the intraspecific divergence associated with environmental variation coincided with interspecific divergence. The results indicate that mother trees from different habitats transmit divergent trait values to their progeny, and suggest that local environmental variation selects for different trait optima even at a very local spatial scale. Traits for which differentiation within species follows the same pattern as differentiation between species indicate that the same ecological processes underlie intra- and interspecific variation.
ISSN: 0305-7364

hal-01032430
https://hal.archives-ouvertes.fr/hal-01032430
DOI : 10.1093/aob/mct176

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: Phthalic acid esters are widely used in the manufacture of plastics. Numerous studies have shown that these phthalates impair testicular testosterone production in the rat. However, the scarce and contradictory data concerning humans have cast doubt over whether these compounds are also anti-androgenic in man. We therefore investigated the direct effects of di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) on organo-cultured adult human testis and a human cell line. METHODS: Adult human testis explants or NCI-H295R adrenocortical human cells were cultured with DEHP or MEHP. The effects of ketoconazole, used as a reference molecule, were also assessed. RESULTS: In both models, DEHP and MEHP significantly inhibited testosterone production. The effects of both phthalates appeared to be specific for steroidogenesis, as INSL3 production by Leydig cells was not altered. Furthermore, the phthalates of interest had no effect on inhibin B production by Sertoli cells or on germ cell apoptosis. As only a small fraction of the phthalates added was found in the testis explants, and as these compounds were found to be metabolized, we estimate that the anti-androgenic effects observed occurred at concentrations of phthalates that are of the same order of magnitude as exposures reported in the literature for men. CONCLUSIONS: We provide the first evidence that DEHP and MEHP can inhibit testosterone production in the adult human testis. This is consistent with recent epidemiological findings of an inverse correlation between exposure to MEHP and testosterone concentrations.
ISSN: 0268-1161

hal-00876965
https://hal.archives-ouvertes.fr/hal-00876965
DOI : 10.1093/humrep/des069
PUBMED : 22402212

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Background and Aims: In rain forests, sapling survival is highly dependent on the regulation of trunk slenderness (height/diameter ratio): shade-intolerant species have to grow in height as fast as possible to reach the canopy but also have to withstand mechanical loadings (wind and their own weight) to avoid buckling. Recent studies suggest that mechanosensing is essential to control tree dimensions and stability-related morphogenesis. Differences in species slenderness have been observed among rainforest trees; the present study thus investigates whether species with different slenderness and growth habits exhibit differences in mechanosensitivity. Methods: Recent studies have led to a model of mechanosensing (sum-of-strains model) that predicts a quantitative relationship between the applied sum of longitudinal strains and the plant's responses in the case of a single bending. Saplings of five different neotropical species (Eperua falcata, E. grandiflora, Tachigali melinonii, Symphonia globulifera and Bauhinia guianensis) were subjected to a regimen of controlled mechanical loading phases (bending) alternating with still phases over a period of 2 months. Mechanical loading was controlled in terms of strains and the five species were subjected to the same range of sum of strains. The application of the sum-of-strain model led to a dose-response curve for each species. Dose-response curves were then compared between tested species. Key Results: The model of mechanosensing (sum-of-strain model) applied in the case of multiple bending as long as the bending frequency was low. A comparison of dose-response curves for each species demonstrated differences in the stimulus threshold, suggesting two groups of responses among the species. Interestingly, the liana species B. guianensis exhibited a higher threshold than other Leguminosae species tested. Conclusions: This study provides a conceptual framework to study variability in plant mechanosensing and demonstrated interspecific variability in mechanosensing.
ISSN: 0305-7364

halsde-00454145
https://hal.archives-ouvertes.fr/halsde-00454145
DOI : 10.1093/aob/mcp286

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
We analyse temporal variations of gravity measured in southern Taiwan since November 2006 at 10 sites using absolute gravimeters and, since November 2008, at 70 sites using a relative gravimeter. We describe and apply methods to interpret the gravity changes in terms of local hydrological processes and vertical ground motions. The effect of land water is computed from local rainfall data and a model of rain accumulation and discharge in the ground. The effect of the vertical motions of the ground is estimated using time-series of permanent Global Positioning System (GPS) stations and the theoretical gravity to height ratio of −2 μGal cm−1. Unexpectedly, Morakot typhoon (2009 August), the strongest typhoon in Taiwan in 50 yr, was responsible for the highest gravity changes. Morakot triggered numerous large landslides and debris flow deposits. Their thicknesses are estimated from the gravity changes (up to ∼280 μGal) along with field observations and satellite images.
ISSN: 0956-540X

hal-00768216
https://hal.archives-ouvertes.fr/hal-00768216
DOI : 10.1093/gji/ggs019

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : Publication Inra prise en compte dans l'analyse bibliométrique des publications scientifiques mondiales sur les Fruits, les Légumes et la Pomme de terre. Période 2000-2012. http://prodinra.inra.fr/record/256699
Background and Aims Plastic tree-shelters are increasingly used to protect tree seedlings against browsing animals and herbicide drifts. The biomass allocation in young seedlings of deciduous trees is highly disturbed by common plastic tree-shelters, resulting in poor root systems and reduced diameter growth of the trunk. The shelters have been improved by creating chimney-effect ventilation with holes drilled at the bottom, resulting in stimulated trunk diameter growth, but the root deficit has remained unchanged. An experiment was set up to elucidate the mechanisms behind the poor root growth of sheltered Prunus avium trees. Methods Tree seedlings were grown either in natural windy conditions or in tree-shelters. Mechanical wind stimuli were suppressed in ten unsheltered trees by staking. Mechanical stimuli (bending) of the stem were applied in ten sheltered trees using an original mechanical device. Key Results Sheltered trees suffered from poor root growth, but sheltered bent trees largely recovered, showing that mechano-sensing is an important mechanism governing C allocation and the shoot-root balance. The use of a few artificial mechanical stimuli increased the biomass allocation towards the roots, as did natural wind sway. It was demonstrated that there was an acclimation of plants to the imposed strain. Conclusions This study suggests that if mechanical stimuli are used to control plant growth, they should be applied at low frequency in order to be most effective. The impact on the functional equilibrium hypothesis that is used in many tree growth models is discussed. The consequence of the lack of mechanical stimuli should be incorporated in tree growth models when applied to environments protected from the wind (e.g. greenhouses, dense forests).
ISSN: 0305-7364

hal-01032056
https://hal.archives-ouvertes.fr/hal-01032056
DOI : 10.1093/aob/mcn054

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Two types of olivine occur in kimberlites from Greenland, Canada and southern Africa. The first, xenocrystic olivine, displays several different forms. Most distinctive are 'nodules', a term we use to describe the large (1-5 mm), rounded, single crystals or polycrystalline aggregates that are a common constituent of many kimberlites. Olivine compositions are uniform within single nodules but vary widely from nodule to nodule, from Fo81 to 93. Within many nodules, sub- to euhedral asymmetric tablets have grown within larger anhedral olivine grains. Dislocation structures, particularly in the anhedral grains, demonstrate that this olivine was deformed before being incorporated into the kimberlite magma. Olivine grains in the kimberlite matrix between the nodules have morphologies similar to those of the tablets, suggesting that most matrix olivine grains are parts of disaggregated nodules. We propose that a sub- to euhedral form is not sufficient to identify phenocrysts in kimberlites and provide some criteria, based on morphology, internal deformation and composition, that distinguish phenocrysts from xenocrysts. The second type of olivine is restricted to rims surrounding xenocrystic grains. Only this olivine crystallized from the kimberlite magma. Major and trace element data for the rim olivine are used to calculate the composition of the parental kimberlite liquid, which is found to contain between about 20 and 30% MgO. The bulk compositions of many kimberlites contain higher MgO contents as a result of the presence of xenocrystic olivine. The monomineralic, dunitic, character of the nodules, and the wide range from Fo-rich to Fo-poor olivine compositions, provide major constraints on the origin of the nodules. Dunite is a relatively rare rock in the mantle and where present its olivine is persistently Fo-rich. The dunitic source of the nodules in kimberlites lacked minerals such as pyroxene and an aluminous phase, which make up about half of most mantle-derived rocks. It appears that these minerals were removed from the mantle peridotite that was to become the source of the nodules, and the Fo content of the retained olivine was modified during interaction with CO2-rich fluids whose arrival at the base of the lithosphere immediately preceded the passage of the kimberlite magmas. Fragments of the resultant dunite were entrained into the kimberlite, where they were retained both as intact nodules and as disaggregated grains in the matrix.
ISSN: 0022-3530

insu-00543321
https://hal-insu.archives-ouvertes.fr/insu-00543321
BIBCODE : 10.1093/petrology/egp080
DOI : 10.1093/petrology/egp080

Éditeur(s) : HAL CCSD Oxford University Press (OUP): Policy B - Oxford Open Option A
Résumé :  
absent
Journal of Experimental Botany

hal-01032195
https://hal.archives-ouvertes.fr/hal-01032195
DOI : 10.1093/jxb/erp276

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
Pre-Columbian sites with similar artifacts were excavated at an early date in Trinidad (Howard 1943) and the West Indies (Rouse 1940), but the classification of these sites as reflecting a common culture area was not achieved until Cruxent and Rouse (1958/1959) defined the Saladoid "series" (i.e., related "peoples and cultures") following research in the Orinoco River valley of Venezuela. This name became widely adopted following the first international convention for the study of the pre-Columbian cultures of the Lesser Antilles in 1961, and it quickly replaced the appellation "Arawak" to designate the first Antillean ceramic groups. The Saladoid series culture area includes the Orinoco River basin, parts of the north coast of South America, and the Lesser Antilles and Puerto Rico. This chapter present the state of art about Saladoid series.
The Oxford Handbook of Caribbean Archaeology

Droits : info:eu-repo/semantics/OpenAccess
ISBN : 978-0-19-539230-2
hal-00968898
https://hal.univ-antilles.fr/hal-00968898
https://hal.univ-antilles.fr/hal-00968898/document
https://hal.univ-antilles.fr/hal-00968898/file/Chap13saladoid.pdf

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Retreatment with pegylated interferon (peg-IFN) and ribavirin (RBV) results in poor sustained virological response (SVR) rates in human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients. There are limited data regarding the use of telaprevir plus peg-IFN/RBV in this population. HIV type 1-infected patients who previously failed ≥12 weeks of peg-IFN/RBV for HCV genotype 1 coinfection were enrolled in a single-arm, phase 2 trial. Patients with cirrhosis and previous null response were excluded. Authorized antiretrovirals were tenofovir, emtricitabine, efavirenz, atazanavir, and raltegravir. All patients received peg-IFN alfa-2a (180 µg/week) plus RBV (1000-1200 mg/day) for 4 weeks, followed by telaprevir (750 mg or 1125 mg every 8 hours with efavirenz) plus peg-IFN/RBV for 12 weeks and peg-IFN/RBV for 32-56 weeks according to virological response at week 8. The primary endpoint was the SVR rate at 24 weeks after the end of treatment (SVR24). Sixty-nine patients started treatment; SVR24 was achieved in 55 (80% [95% confidence interval, 68%-88%). SVR24 was not influenced by baseline fibrosis stage, IL28B genotype, antiretroviral regimen, HCV subtype, CD4 cell count, previous response to HCV treatment, HCV RNA level, or HCV RNA decline at week 4. HCV treatment was discontinued for adverse events (AEs) in 20% of patients, including cutaneous (4%), psychiatric (4%), hematological (6%), and other AEs (6%). Peg-IFN or RBV dose reduction was required in 23% and 43% of patients, respectively. Seventy percent of patients required erythropoietin, blood transfusions, or RBV dose reduction for anemia. Two patients died during the study. No HIV breakthrough was observed. Despite a high discontinuation rate related to toxicity, a substantial proportion of treatment-experienced HIV-coinfected patients achieved SVR24 with a telaprevir-based regimen. Clinical Trials Registration. NCT01332955.
ISSN: 1058-4838

hal-01118447
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118447
PUBMED : 25139963
DOI : 10.1093/cid/ciu659

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
We use 3 yr of surface absolute gravity measurements at three sites on the Larzac plateau (France) to quantify the changes induced by topography and the building on gravity time-series, with respect to an idealized infinite slab approximation. Indeed, local topography and buildings housing ground-based gravity measurement have an effect on the distribution of water storage changes, therefore affecting the associated gravity signal. We first calculate the effects of surrounding topography and building dimensions on the gravity attraction for a uniform layer of water. We show that a gravimetric interpretation of water storage change using an infinite slab, the so-called Bouguer approximation, is generally not suitable. We propose to split the time varying gravity signal in two parts (1) a surface component including topographic and building effects (2) a deep component associated to underground water transfer. A reservoir modelling scheme is herein presented to remove the local site effects and to invert for the effective hydrological properties of the unsaturated zone. We show that effective time constants associated to water transfer vary greatly from site to site. We propose that our modelling scheme can be used to correct for the local site effects on gravity at any site presenting a departure from a flat topography. Depending on sites, the corrected signal can exceed measured values by 5-15 μGal, corresponding to 120-380 mm of water using the Bouguer slab formula. Our approach only requires the knowledge of daily precipitation corrected for evapotranspiration. Therefore, it can be a useful tool to correct any kind of gravimetric time-series data.
ISSN: 0956-540X

hal-00795590
https://hal.archives-ouvertes.fr/hal-00795590
DOI : 10.1093/gji/ggs007

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
IODP Expedition 352 cored igneous rocks from the Izu-Bonin-Mariana forearc crust. Cores from Sites U1440 and U1441 recovered Eocene basalts and related rocks and cores from Sites U1439 and U1442 recovered Eocene boninites and related rocks. We selected samples from Holes U1439C, U1440B and U1442A for palaeointensity measurements. Hysteresis measurements and high and low-temperature magnetization curves show that samples from Hole U1440B undergo magneto-chemical changes when heated and are mostly composed of single-domain (SD) or pseudo-single-domain (PSD) titanomaghemite. In contrast, the same measurements show that most selected samples from Holes U1439C and U1442A are thermally stable and are composed of either SD or PSD titanomagnetite with very little titanium content, or SD ferromagnetic grains with a large paramagnetic contribution. Thellier–Thellier palaeointensity experiments carried out on U1439C and U1442A samples give a good success rate of 25/60 and Virtual Dipole Moment (VDM) values between 1.3 and 3.5 × 1022 Am2. Multispecimen palaeointensity experiments with the domain-state corrected method carried out on 55 samples from Hole U1440B (divided into four groups) and 20 from Hole U1439C gave poor quality results, but indicated a VDM around 4–6 × 1022 Am2 in Hole U1440B forearc basalts. These results are in agreement with the few, low VDM values previously measured on Eocene rocks. However, they do not support an inverse relationship between field intensity and reversal rate for this period of time, since the Eocene reversal rate was low.
ISSN: 0956-540X

hal-01622775
https://hal.archives-ouvertes.fr/hal-01622775
https://hal.archives-ouvertes.fr/hal-01622775/document
https://hal.archives-ouvertes.fr/hal-01622775/file/carvalloGJI2017.pdf
DOI : 10.1093/gji/ggx208

Éditeur(s) : HAL CCSD Oxford University Press (OUP): Policy P - Oxford Open Option A Oxford University Press (OUP)
Résumé : International audience
While the kinematics of Anatolia plate and the North Anatolian Fault System (NAFS) has been studied extensively, the slip rate and locking depth along the NAFS are usually assumed constant in the analyses due to the lack of sufficient data. This is also partly due to the reasonably good fit of Euler small circle and partly due to the lack of spatial resolution of observations to determine slip rates independently from locking depths. On the other hand, recent geodetic studies show a contrast for locking depth between Marmara and other parts of the NAFS, implying a non-uniform locking depth across the NAFS. In this study, we analyse new GPS data and homogenously combine available data sets covering the eastern part of the NAFS to form the most complete data set. In particular, we incorporate the first results of Turkish Real-Time Kinematic GPS Network (CORS-TR) into our data set. A detailed analysis of three profiles within the NAFS reveals an increase of locking depth in the middle profile to 19.1 ± 3.4 km from 11.9 ± 3.5 km in the easternmost profile while the slip rate is nearly constant (20–22 mm yr−1), which implies a variation of strain rate of ∼100 nanostrain yr−1. Assuming a constant locking depth throughout whole NAFS gives an average locking depth of 14.3 ± 1.7 km. Our best estimates of slip rates in block modelling which takes the variation of locking depths into account are in the range between 22.5 and 22.8 mm yr−1 over eastern part of the NAFS.
ISSN: 0956-540X

hal-01218392
https://hal.archives-ouvertes.fr/hal-01218392
DOI : 10.1093/gji/ggv274

Éditeur(s) : HAL CCSD Oxford University Press (OUP): Policy B - Oxford Open Option B
Résumé : absent
ISSN: 0829-318X

hal-01031083
https://hal.archives-ouvertes.fr/hal-01031083

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Although semen is the principal vector of human immunodeficiency virus (HIV) dissemination worldwide, the origin of the infected leukocytes and free viral particles in this body fluid remain elusive. Here we review the accumulated evidence of the genital origin of HIV in semen from therapy naive individuals and men receiving suppressive highly active antiretroviral therapy (HAART), summarize the data on the detection and localization of HIV/SIV within the male genital tract, discuss the potential involvement of each genital tissue as a source of infected cells and virions in semen in the absence and presence of HAART, and suggest further studies. Deciphering the exact sources of HIV in semen will be crucial to improving HIV transmission prevention strategies.
ISSN: 0022-1899

hal-01121761
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01121761
PUBMED : 25414416
DOI : 10.1093/infdis/jiu328

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
The activity of diethylcarbamazine (DEC) and suramin (S) on Litomosoides carinii filariasis was assessed by the study of microfilaraemia in 30 cotton-rats (Sigmodon hispidus). DEC (per os) and S (injected subcutaneously) were administered alone or in combination, at doses of 50 mg/kg/day for five consecutive days. 15 rats were treated at day 91 after infection and 15 others at day 184. The immediate but temporary efficacy observed with DEC was in contrast to the delayed and long-lasting effect of S. With combined therapy there was neither antagonism nor synergism. The demonstration of an apparently smaller reduction of parasitaemia in the rats treated with DEC before the plateau phase of the microfilaraemia was consistent with the lack of action of this drug on microfilariae outside the blood system.
ISSN: 0035-9203

hal-00717073
https://hal.univ-antilles.fr/hal-00717073
PUBMED : 7034313