Éditeur(s) : Caribbean Volunteer Expeditions Caribbean Volunteer Expeditions ( Corning, NY )

Droits : All rights reserved by the source institution.

Éditeur(s) : Elsevier
Résumé : During the Fanindien 2006 cruise of R/V 'Beautemps-Beaupre', high resolution multibeam bathymetry, sub-bottom profiling and sediment coring was carried out along the East African margin, offshore Tanzania and Mozambique (Indian Ocean). The newly acquired data reveal the presence of a giant deep-sea valley (the Tanzania channel) that is more than 10 km wide at 4000 m water depth, along the continental rise. The valley remains similar to 70 m deep and 7 km wide at 800 km from the Tanzania coast. Morphological comparison with worldwide submarine channels show that the Tanzania channel is one of the largest known submarine valleys. This discovery brings new light on development of submarine valleys that drain sediments originated from the East African Rift System (EARS) highlands (i.e. the Tanzania channel and its neighbor Zambezi channel located similar to 1000 km southward). Both of the systems have a morphology markedly different to the classical sinuous, V-shaped channels located at similar latitudes (e.g. the Zaire or Amazon channels). Their submarine drainage system consists of a downslope converging tributary canyons joining a central trunk channel in the continental rise. The presence of such giant deep-sea drainage systems is probably linked to a strong structural control on the sediment pathway, associated to a massive sediment transfer towards the Indian Ocean in relation with the tectonic activity of the East African Rift System (i.e. the uplift periods trough mid-Miocene and Plio-Pleistocene times) and its interplay with the East African equatorial climate changes.
Marine Geology (0025-3227) (Elsevier), 2008-12 , Vol. 255 , N. 3-4 , P. 179-185

Droits : 2008 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/00324/43491/42958.pdf
DOI:10.1016/j.margeo.2008.09.002
http://archimer.ifremer.fr/doc/00324/43491/

Éditeur(s) : Elsevier
Résumé : During the Fanindien 2006 cruise of R/V 'Beautemps-Beaupre', high resolution multibeam bathymetry, sub-bottom profiling and sediment coring was carried out along the East African margin, offshore Tanzania and Mozambique (Indian Ocean). The newly acquired data reveal the presence of a giant deep-sea valley (the Tanzania channel) that is more than 10 km wide at 4000 m water depth, along the continental rise. The valley remains similar to 70 m deep and 7 km wide at 800 km from the Tanzania coast. Morphological comparison with worldwide submarine channels show that the Tanzania channel is one of the largest known submarine valleys. This discovery brings new light on development of submarine valleys that drain sediments originated from the East African Rift System (EARS) highlands (i.e. the Tanzania channel and its neighbor Zambezi channel located similar to 1000 km southward). Both of the systems have a morphology markedly different to the classical sinuous, V-shaped channels located at similar latitudes (e.g. the Zaire or Amazon channels). Their submarine drainage system consists of a downslope converging tributary canyons joining a central trunk channel in the continental rise. The presence of such giant deep-sea drainage systems is probably linked to a strong structural control on the sediment pathway, associated to a massive sediment transfer towards the Indian Ocean in relation with the tectonic activity of the East African Rift System (i.e. the uplift periods trough mid-Miocene and Plio-Pleistocene times) and its interplay with the East African equatorial climate changes. (C) 2008 Elsevier B.V. All rights reserved.
Marine Geology (0025-3227) (Elsevier), 2008-12 , Vol. 255 , N. 3-4 , P. 179-185

Droits : 2008 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/2008/publication-6855.pdf
DOI:10.1016/j.margeo.2008.09.002

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0012-8252

hal-01671832
https://hal-univ-rochelle.archives-ouvertes.fr/hal-01671832
DOI : 10.1016/j.earscirev.2016.12.005

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : International audience
Age constraints on the protoliths, deformation, metamorphism and melting events are key parameters when correlating different continental lithospheric remnants among each other and disentangling their evolution within large-scale orogens. In situ U-Th-Pb chemical dating on monazites using Electron Probe Micro-Analyser (EPMA) has been performed on eight samples throughout the Variscan Maures-Tanneron massif (SE France) in order to date the medium to high-tectonothermal events related to the Variscan orogeny.Results indicate a polyphased crustal evolution : (i) U-Th-Pb ages obtained in polygenetic monazite grain cores gave inherited Upper Ordovician (456 ± 11 Ma) age, highlighting the large scale occurrence of the Ordovician magmatic activity in the North Gondwanian margin. An Early Devonian (404 ± 10 Ma) age may date a protolith emplacement related to calc-alkaline supra-subduction magmatism or could be associated to an early medium-grade metamorphism, prior to collisional stage. (ii) The crustal thickening stage has been further recorded in prograde metamorphic monazites formed during the underthrusting and subsequent nappe stacking events, under amphibolite facies conditions. This stage is dated between 382 ± 11 (Middle Devonian) and 331 ± 5 Ma (Late Visean). (iii) An orogenic partial melting event took place during Middle Carboniferous and is accompanied by the crystallization of crustal peraluminous magmas (Plan-de-la-Tour granite, 329 ± 3 Ma).This contribution demonstrates the capacity of monazite to record the prograde path of rocks during increasing metamorphic conditions related to stages of crustal thickening, and the robustness of the U-Th-Pb chronometer in monazite despite the overprinting of high-grade thermal events, including partial melting. The age ranges of the different orogenic stages reported in this study are in good agreement with those reported in adjacent Variscan Corsica and Sardinia; while correlations with other nearest Variscan massifs like the Argentera massif in the southwestern Alps or the French Massif Central remain more hypothetic. The Internal Zone of the Maures-Tanneron massif, and more widely the Internal Zone of the Maures-Tanneron-Corsica-Sardinia segment, is part of the southern orogenic root system of the Variscan belt.
EISSN: 1777-5817

insu-01140973
https://hal-insu.archives-ouvertes.fr/insu-01140973
DOI : 10.2113/gssgfbull.186.2-3.145

Éditeur(s) : HAL CCSD Elsevier
Résumé : Understanding chemical element mobility during high-pressure metamorphism is paramount to the knowledge of the transformations occurring during the course of eclogite-facies metamorphism. In particular, the role of deformation and fluid circulation appear essential. In order to better decipher this role, we investigated two eclogite-facies samples from the Lindas Nappe in the Bergen arcs (Norwegian Caledonides), which are related to a fluid/deformation metamorphic event. This study, based on detailed microtextural investigations, coupled with major and trace element analyses, either in situ EMPA and LA-ICP-MS or by conventional ICP-MS nebulisation on mineral fractions, illustrates the complexity of chemical reactions accompanying the eclogite- and amphibolite-facies metamorphism. A single eclogite-facies mineral species two eclogite-facies (i.e. phengite and epidote) depicts various chemical features depending on its textural location at thin-section scale. The correlation with the mineralogical reaction occurring in each textural site demonstrates that the compositional variations are inherited from the precursor minerals. Thus, the composition of eclogite-facies minerals is locally controlled by the composition of few hundred-micron domains. On the contrary, alteration phases of the amphibolite facies (symplectite and calcic amphibole) display clear enrichment in LILE, Pb, Sr and LREE compared to their precursor minerals (omphacite and garnet). This supports that the transport of elements at hand-sample scale was enhanced during the retrogression and elements were efficiently delocalised from one textural site to another. The contrasting behaviour of element mobility between peak eclogite-facies metamorphism and retrogression can be explained in terms of rate processes and fluid/deformation activity. During eclogitisation,deformation allows the formation of textural and mineralogical microdomains. Contemporaneously the fluid circulation favours the development of heterogeneities by transport of elements in excess towards areas protected from deformation where phengite-bearing quartz lenses crystallise. This, together with the very fast recrystallisation of eclogite-facies minerals, results in a heterogeneous redistribution of elements at sample scale and in a chemical disequilibrium between different microdomains of hundred-micron size. During retrogression in the amphibolite facies, coeval with long-term ductile deformation, the fluids act as an efficient vector to redistribute the elements from a given textural site to another and, thus, allow to reach, at hand-sample scale, a new chemical equilibrium between the different crystallising phases.
ISSN: 0024-4937

hal-00404602
https://hal.archives-ouvertes.fr/hal-00404602
DOI : 10.1016/j.lithos.2006.10.001

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
Rheological properties of mantle minerals and rocks at temperatures (T) appropriate to much of Earth's lithosphere have remained poorly constrained, even though past experimental studies on olivine single crystals and polycrystalline aggregates have quantified the high-temperature creep mechanisms (T > 1200 degrees C). Consequently, we have performed deformation experiments on crystals of San Carlos olivine at lower temperatures, from 900 degrees to 1200 degrees C, in triaxial compression along the [101](c) direction. The experiments were carried out at a confining pressure of 300 MPa in a high-resolution gas-medium mechanical testing apparatus at differential stresses of 100 to 500 MPa. Several samples were deformed at constant displacement rate and others at constant load, in order to provide insight into possible effects of work-hardening. Under the deformation conditions investigated, little evidence of work-hardening was observed. The data follow a power-law dependence on stress, as in previous high-temperature deformation studies. The samples were, however, considerably weaker than predicted by the experimentally determined high-temperature constitutive equation for olivine crystals of this orientation from the study of Bai et al. (1991). The mechanical behavior correlates instead with the weaker of the two mechanisms (flow laws) that contribute to the high-temperature constitutive equation. Thus, our experiments demonstrate that published high-temperature constitutive equations overestimate the strength of lithospheric mantle and that the transition to low-temperature creep occurs at lower temperatures than previously inferred. Citation: Demouchy, S., S. E. Schneider, S. J. Mackwell, M. E. Zimmerman, and D. L. Kohlstedt (2009), Experimental deformation of olivine single crystals at lithospheric temperatures, Geophys. Res. Lett., 36, L04304, doi: 10.1029/2008GL036611.
ISSN: 0094-8276

hal-00420070
https://hal.archives-ouvertes.fr/hal-00420070
DOI : 10.1029/2008GL036611

Éditeur(s) : Société Nationale de Protection de la Nature
Résumé : Monitoring of French Polynesia coral reefs and their recent development.-French Polynesia, consisting of 118 islands in the centre of the Pacific Ocean, has more than 15 000 km(2) of reefs and lagoons managed by the local government. Tourism and pearl culture are the two main economic resources of the country. Polynesian coral reefs are extremely diverse and are among those for which we have thorough knowledge. The exploitation of local resources has been recorded for multiple decades and includes : coral materials, fishing, harvest and export of mother-of-pearl molluscs, pearl production, and ornamental fish. All over the country, many monitoring programmes have been launched to measure the health of reefs and the natural and anthropogenic perturbations that they suffer : hurricanes and seismic events, water quality, health of benthic and fish communities, pearl oyster pathology and radiobiology. These data, collected over the last few decades, allowed to define the relative importance of natural and anthropogenic degradation on reefs and lagoons, and to explain the present status of reefs at different spatial scales. Devastating hurricanes are rare (1903-1906, 1982-1983 and occasionally at other times), but they may annihilate outer slope coral communities on some islands. Bleaching events with considerable coral mortality at different geographical scales occurred mainly in 1991, 1994 and 2003. Outbreaks of Acanthaster destroyed numerous reefs (lagoons and outer slopes) from 1978-1982 and a new demographic wave began in 2006 at many Society islands. Eutrophication events only occurred occasionally and only in some lagoons. Whereas natural catastrophic events degrade the coral reef ecosystem across many islands, at the archipelago or even regional scale, anthropogenic degradation is limited to a few Society Islands, occurring rarely on atolls and not at all on those (one third) which are uninhabited. The main causes of reef degradation in some areas of Tahiti and Moorea include the embankment of fringing zones, coral mining, overfishing, absence of urban sewage treatment and the development of leisure and tourism activities. Because of its large geographical extent, one may conclude that major reef degradation in French Polynesia is caused by catastrophic natural events. On the other hand, anthropogenic degradation is more localized. Unfortunately, the synergistic effects of these causes of degradation prevent reefs from recovering. Optimum coral cover on French Polynesian outer reef slopes is between 50-60%. After a major destructive impact (hurricane, bleaching, Acanthaster) a reef is reduced to less than 10% coral cover, however if no more major disturbance events occur a reef will recover in about 12 years. Most of the 15 000 km(2) of reefs and lagoons in French Polynesia are in good health, and along with their neighbouring reefs in East and Central Pacific they are considered as the least degraded reefs worldwide and at a low risk of becoming degraded in the few next decades. However, we are more and more anxious about the future of reefs in the world particularly because present simulations predict that major impacts of climate change would include : elevation of sea surface temperatures, increase in the strength of hurricanes and acidification of seawater which will affect the formation of coral structures.
La Polynésie française, 118 îles au coeur du Pacifique, possède une surface de plus de 15 000 km2 de récifs et lagons gérés par le gouvernement polynésien. Le tourisme et la perliculture représentent les deux ressources économiques majeures du Pays. Les formations récifales très diversifiées sont parmi les mieux connues. Plusieurs suivis d'exploitation des ressources sont opérationnels depuis des décennies : granulats coralliens, pêche pour l'alimentation, collecte et exportation de mollusques nacriers, production de perles, poissons d'ornement. À l'échelle du Pays de très nombreux programmes de surveillance de l'état des récifs et des perturbations qu'ils subissent, naturelles et anthropiques, ont été mis en place : perturbations cycloniques et sismiques, qualité des eaux, état de santé des peuplements benthiques et ichtyologiques, pathologie des nacres, radiobiologie. Toutes ces données recueillies au fi l des décennies ont permis d'établir l'importance relative des dégradations naturelles et anthropiques sur les récifs et lagons polynésiens et d'expliquer leur état de santé actuel en considérant différentes échelles spatiales. Les périodes cycloniques dévastatrices pour les récifs sont rares (1903-1906, 1982-1983 et épisodiquement) mais les cyclones ont parfois anéanti les communautés coralliennes de pentes externes dans certaines îles. Les blanchissements suivis de mortalités importantes à des échelles spatiales diverses, ont été surtout ceux de 1991, 1994 et 2003. Les explosions démographiques d'Acanthaster ont détruit de nombreux récifs (lagons et pentes externes) en 1978-1982 et une nouvelle pullulation s'amplifie depuis 2006 dans plusieurs îles de la Société. Les crises dystrophiques n'ont perturbé qu'épisodiquement certains lagons. [...]
Revue d'Ecologie de la Terre et de la Vie (0249-7395) (Société Nationale de Protection de la Nature), 2008 , Vol. 63 , N. 1-2 , P. 145-177

Droits : 2008 Société Nationale de Protection de la Nature
http://archimer.ifremer.fr/doc/2008/publication-4558.pdf
http://archimer.ifremer.fr/doc/00000/4558/

Éditeur(s) : HAL CCSD springer Link
Résumé : International audience
Experimental Astronomy

hal-01094521
https://hal.archives-ouvertes.fr/hal-01094521
BIBCODE : 2014ExA...tmp...41R
DOI : 10.1007/s10686-014-9383-4
ARXIV : 1310.0696

Éditeur(s) : HAL CCSD American Public Health Association
Résumé : International audience
BACKGROUND: It is well established that high adherence to HIV-infected patients on highly active antiretroviral treatment (HAART) is a major determinant of virological and immunologic success. Furthermore, psychosocial research has identified a wide range of adherence factors including patients' subjective beliefs about the effectiveness of HAART. Current statistical approaches, mainly based on the separate identification either of factors associated with treatment effectiveness or of those associated with adherence, fail to properly explore the true relationship between adherence and treatment effectiveness. Adherence behavior may be influenced not only by perceived benefits-which are usually the focus of related studies-but also by objective treatment benefits reflected in biological outcomes. METHODS: Our objective was to assess the bidirectional relationship between adherence and response to treatment among patients enrolled in the ANRS CO8 APROCO-COPILOTE study. We compared a conventional statistical approach based on the separate estimations of an adherence and an effectiveness equation to an econometric approach using a 2-equation simultaneous system based on the same 2 equations. RESULTS: Our results highlight a reciprocal relationship between adherence and treatment effectiveness. After controlling for endogeneity, adherence was positively associated with treatment effectiveness. Furthermore, CD4 count gain after baseline was found to have a positive significant effect on adherence at each observation period. This immunologic parameter was not significant when the adherence equation was estimated separately. In the 2-equation model, the covariances between disturbances of both equations were found to be significant, thus confirming the statistical appropriacy of studying adherence and treatment effectiveness jointly. CONCLUSIONS: Our results, which suggest that positive biological results arising as a result of high adherence levels, in turn reinforce continued adherence and strengthen the argument that patients who do not experience rapid improvement in their immunologic and clinical statuses after HAART initiation should be prioritized when developing adherence support interventions. Furthermore, they invalidate the hypothesis that HAART leads to "false reassurance" among HIV-infected patients.
ISSN: 0025-7079

hal-00875196
https://hal.archives-ouvertes.fr/hal-00875196
DOI : 10.1097/MLR.0b013e3182422f61
PUBMED : 22362167

Éditeur(s) : HAL CCSD Universidad Complutense de Madrid
Résumé : The Lodève Permian synrift sequence is represented by thick stacked climate-controled playa cycles which have been constrained by structural, sedimentological, geochemical and paleontological processes. The present paper merges the different results in order to better constrain the dynamics and palaeoecologycal evolution of the playa system from Late Cisuralian to Early Lopingian time. In this depositional environment, thining upwards sheet-flood sequences represent flooding events; they are relayed by ephemeral ponding, suspension settling and limited carbonate precipitation accompanied by large amounts of shallow to subaerial sedimentary structures... (Ver más) (current and wind ripples, desiccation cracks, rain drops, etc.). The aridity of the climate contrasts with the surprising abundance of the fauna encountered into carbonate-rich silty-clay playa-lake deposits. Ephemeral pools are colonized by numerous shellfish: Choncostraca, Triopsids, and Insects, which led to intense burrowing of the overbank deposits (Scoyenia facies). Tetrapods are common and dominated by several types of reptiles after footprints: Pelycosauria, Parareptilia and Lepidosauria in the Rabejac Fm, and Mammalian reptiles (Therapsida) on the top of the fluvial deposits of the Salagou Fm near La Lieude farm. In addition, elements of a weighty herbivorous Pelycosaurian and a small amphibian Tupilakosaurid, only described in the Triassic before, have been also found in the Upper part of the Permian series of this sector.
ISSN: 1698-6180

hal-00411539
https://hal.archives-ouvertes.fr/hal-00411539

Éditeur(s) : HAL CCSD American Chemical Society
Résumé : International audience
Four bicyclic and three pentacyclic guanidine alkaloids (1–7) were isolated from a French Polynesian Monanchora n. sp. sponge, along with the known alkaloids monalidine A (8), enantiomers 9–11 of known natural product crambescins, and the known crambescidins 12–15. Structures were assigned by spectroscopic data interpretation. The relative and absolute configurations of the alkaloids were established by analysis of 1H NMR and NOESY spectra and by circular dichroism analysis. The new norcrambescidic acid (7) corresponds to interesting biosynthetic variation within the pentacyclic core. All compounds exhibited antiproliferative and cytotoxic efficacy against KB, HCT116, HL60, MRC5, and B16F10 cancer cells, with IC50 values ranging from 4 nM to 10 μM.
ISSN: 0163-3864

hal-01584556
https://hal.archives-ouvertes.fr/hal-01584556
DOI : 10.1021/acs.jnatprod.6b00168

Éditeur(s) : HAL CCSD SAGE Publications (UK and US)
Résumé : International audience
In this article, we focus on hypomaturation autosomal-recessive-type amelogenesis imperfecta (type IIA2) and describe 2 new causal Matrix metalloproteinase 20 (MMP20) mutations validated in two unrelated families: a missense mutation p.T130I at the expected homozygous state, and a compound heterozygous mutation having the same mutation combined with a nucleotide deletion, leading to a premature stop codon (p.N120fz*2). We characterized the enamel structure of the latter case using scanning electron microscopy analysis and microanalysis (Energy-dispersive X-ray Spectroscopy, EDX) and confirmed the hypomaturation-type amelogenesis imperfecta as identified in the clinical diagnosis. The mineralized content was slightly decreased, with magnesium substituting for calcium in the crystal structure. The anomalies affected enamel with minimal inter-rod enamel present and apatite crystals perpendicular to the enamel prisms, suggesting a possible new role for MMP20 in enamel formation.
ISSN: 0022-0345

hal-01545484
https://hal.archives-ouvertes.fr/hal-01545484
DOI : 10.1177/0022034513488393

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study aimed to identify factors associated with virological response (VR) to raltegravir (RAL)-containing regimens in 468 treatment-experienced but integrase inhibitor-naive HIV-1 patients receiving a RAL-containing regimen. VR was defined at Month 6 (M6) as HIV-1 RNA viral load (VL) <50 copies/mL. The impacts on VR of baseline integrase mutations, VL, CD4 count, genotypic sensitivity score for nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors, and the number of new antiretrovirals used for the first time associated with RAL were investigated. For patients with VL >50 copies/mL at M6, integrase mutations selected were characterised. Median baseline VL was 4.2 log(10)copies/mL (IQR 3.3-4.9 log(10) copies/mL) and CD4 count was 219 cells/mm(3) (IQR 96-368 cells/mm(3)). At M6, 71% of patients were responders. In multivariate analysis, baseline VL and CD4 count and ≥ 2 new antiretrovirals among darunavir, etravirine, maraviroc and enfuvirtide were associated with VR to RAL. Neither HIV-1 subtype nor baseline integrase polymorphisms were associated with VR to RAL. Among 63 failing patients at M6, selection of ≥ 1 change in the integrase gene was observed in 49 (77.8%), and 27/63 (42.9%) were considered as RAL-associated resistance mutations. Factors independently associated with the occurrence of ≥ 1 RAL-associated resistance mutation were VL at failure >3 log(10) and having no new drugs associated with RAL. RAL showed great potency in treatment-experienced patients. The number of new drugs associated with RAL was an important factor associated with VR. HIV-1 subtype and baseline integrase polymorphisms do not influence the RAL VR.
ISSN: 0924-8579

hal-00875083
https://hal.archives-ouvertes.fr/hal-00875083
DOI : 10.1016/j.ijantimicag.2013.02.016
PUBMED : 23562640

Éditeur(s) : American Geophysical Union
Résumé : [1] A multiproxy integrated chronological framework, based on oxygen and carbon stable isotope stratigraphy, biostratigraphy (foraminifera and nannoplankton bioevents and foraminifer assemblage-based climate cyclicity), magnetostratigraphy, sapropel stratigraphy, and C-14 AMS radiometric dates, has been achieved for borehole PRAD1-2, collected in 185.5 m water depth in the central Adriatic. This work was carried out within the European Community project Profiles across Mediterranean Sedimentary Systems (PROMESS1). The 71.2 m long borehole spans a time interval between late MIS 11 and MIS 1 (the last 370 ka), showing a chronological resolution of 500 and 250 years per cm during interglacial and glacial intervals, respectively. At present, this record is the most expanded and continuous marine record available for the Adriatic Basin. Several orbital cycles can be recognized in the PRAD1-2 record: the 100 ka glacial-interglacial fluctuations and the 23 ka precession-related cycles, which in turn control the deposition of sapropel layers. An integrated analysis of short-term oscillations within the Last Glaciation interval (MIS 4-MIS 2) allowed the identification of the Adriatic signature of Dansgaard-Oeschger events, showing the potential to achieve a more refined chronostratigraphic framework for the top part of the PRAD1-2 record. Finally, the age model obtained by this study allowed the chronological integration of the main foraminifera bioevents detected in the borehole as well as of the volcanoclastic layers present in the upper part of the record. Despite its proximal location, PRAD1-2 presents a continuous record and shows the potential to be consistently correlated both with deep-sea and continental records in the Mediterranean region and beyond.
Geochemistry Geophysics Geosystems (1525-2027) (American Geophysical Union), 2008 , Vol. 9 , P. NIL_107-NIL_127

Droits : 2008 American Geophysical Union
http://archimer.ifremer.fr/doc/2008/publication-3605.pdf
DOI:10.1029/2007GC001713
http://archimer.ifremer.fr/doc/00000/3605/

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Hepatocellular carcinoma (HCC) is a particularly severe disease characterized by a high rate of recurrence and death even after surgical resection. Molecular characterization of HCC helps refine prognosis and may facilitate the development of improved therapy. Phosphatidylinositol 4-kinases have recently been identified as cellular factors associated with cancer. Also, phosphatidylinositol 4-kinase type IIIα (PI4KA) is necessary for the propagation of the hepatitis C virus, a major etiological factor for HCC. METHODS: Reverse transcription, quantitative real-time PCR was used to assay PI4KA mRNA. The expression levels were investigated both in a collection of molecularly and clinically characterized hepatic tissues from 344 patients with diverse liver diseases and in human hepatocyte cell lines whose proliferative and differentiation status was controlled by specific culture conditions. Analytical microarray data for 60 HCC and six normal liver tissue samples were exploited to study correlations between PI4KA mRNA levels and cell proliferation markers in vivo. Postoperative disease-specific survival and time to recurrence in a set of 214 patients with HCC were studied by univariate and multivariate analyses. RESULTS: PI4KA mRNA was more abundant in HCC than normal healthy tissues. This upregulation correlated significantly with both poor differentiation and the active proliferation rate in HCC. These associations were confirmed with in vitro models. Moreover, patients with HCC who had been treated by surgical resection and had higher PI4KA mRNA concentrations in their tumor tissue exhibited a higher risk of tumor recurrence (median time: 20 months versus 49 months, P = 0.0012) and shorter disease-specific survival (first quartile time: 16 months versus 48 months, P = 0.0004). Finally, the abundance of PI4KA mRNA proved to be an independent prognostic marker of survival for cases of HCC (hazard ratio = 2.36, P = 0.0064). CONCLUSIONS: PI4KA mRNA could be used as a new molecular marker to improve established prognostic models for HCC. These findings also indicate possible new lines of research for the development of innovative therapeutic approaches targeting PI4KA.
ISSN: 1471-2407

inserm-00934294
http://www.hal.inserm.fr/inserm-00934294
http://www.hal.inserm.fr/inserm-00934294/document
http://www.hal.inserm.fr/inserm-00934294/file/1471-2407-14-7.pdf
DOI : 10.1186/1471-2407-14-7

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : Geochemistry, Geophysics, Geosystems, v. 9, p. Q12001, 2008. http://dx.doi.org/10.1029/2008GC002098
International audience
Rb/Sr, 40Ar/39Ar, and Sm/Nd isotopic data are reported in Caledonian eclogites from the Lindås Nappe, Bergen Arcs, Norway, in order to investigate processes controlling isotopic equilibrium at mineral scale in polymetamorphic rocks. The Bergen Arcs exposes Sveconorwegian ∼950–930 Ma granulites, partially overprinted by Caledonian eclogite-facies metamorphism at ∼425 Ma and amphibolite-facies metamorphism at ∼410 Ma. Geochemical and Rb-Sr data from more than 10 phengite fractions separated from one sample reflect the composition of the microdomain (a few hundred microns in size) in which phengite crystallized. Phengite crystallized after garnet or plagioclase by dissolution-precipitation processes yield apparent age between 700 and 600 Ma. At the time of their crystallization, these phengites inherited the isotopic composition of their precursor minerals, at a microdomain scale. Phengite from quartz veins, which crystallized from elements mobilized by the circulating fluid, yield an age closer to the eclogite-facies metamorphic age. The closed system evolution of the eclogitizing fluid, the segregation of textural and reactional microdomains, the high Sr content of the studied phengite, and the short duration of the recrystallization processes (<1Ma) are interpreted as the main factors responsible for the lack of a Rb/Sr isotopic equilibrium, at the scale of hand samples. Such equilibrium is nevertheless reached in quartz veins where the crystallization of minerals implies that the fluid circulation acted as a factor of isotopic homogenization. The in situ single mineral Ar/Ar datings revealed that both eclogite- and amphibolite-facies minerals are characterized by an excess of radiogenic argon (ages between 425 and 520 Ma). The excess of argon has been inherited from the previous granulite and has been only partially evacuated from the system by the circulating fluid. The apparent Sm/Nd ages from garnets inherited from the granulite-facies metamorphism (c. 930 Ma) are in agreement with previous estimates. This result confirms that the diffusion of Nd in garnet does not occur at temperatures lower than 700°C. This study highlights the complexity of radiochronometer behavior during HP metamorphism and demonstrates that coupling different radiochronometers, such as Ar/Ar and Rb/Sr, does not always guarantee the validity of the geochronological results.
ISSN: 1525-2027

hal-00407885
https://hal.archives-ouvertes.fr/hal-00407885
DOI : 10.1029/2008GC002098

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : International audience
In this paper, we provide the first structural map of Les Saintes archipelago (Guadeloupe, Lesser Antilles). The finite strain pattern displays four families of fault systems characterized by their statistical structural orientations: N000-N020, N050-N070, N090-N110 and N130-N140 trending fault systems. Our onshore results thus underline a fault network much more complex than the one depicted by the previous offshore geophysical investigations around Les Saintes archipelago, which show only N120-N150 trending system. According to the available K-Ar dating of the volcanic rocks and the relative chronology of the faults defined in the field, we determine the deformation history in Les Saintes islands since the last 3 Ma. The four highlighted trending fault systems are already active since the Pliocene and are consistent with the present-day extensional tectonics in the Guadeloupe archipelago compatible with the reactiva-tion of inherited structures at the active arc scale. We interpret the tectonic evolution of Les Saintes islands as the result of interplay between subduction of aseismic ridges (Tiburon and Barracuda ridges) and oblique convergence. Furthermore , we recognized an exhumed geothermal paleo-system in Terre-de-Haut island which is a good analogue of the present-day active Bouillante geothermal system. Its duration is estimated at 400 k.y. during the Pliocene.
EISSN: 1777-5817

hal-01625778
https://hal.univ-antilles.fr/hal-01625778
https://hal.univ-antilles.fr/hal-01625778/document
https://hal.univ-antilles.fr/hal-01625778/file/VeratIEtAl_Final.pdf
DOI : 10.2113/gssgfbull.187.1.3