Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
INTRODUCTION:The frequency, the clinical characteristics, and the prognosis of dengue is highly variable. Dengue fever is associated with a range of neurological manifestations. The objective of the present study was to determine the incidence of neurological signs and their predictive factors using data from cases of dengue seen and followed in Cayenne Hospital during the Dengue 2 epidemic in 2013.METHODS:In 2013, a longitudinal study using data from all cases of dengue seen in Cayenne hospital was collected. Medical records used a standardized form to collect demographic information, clinical signs and biological results and the date at which they were present. The analysis used Cox proportional modeling to obtain adjusted Hazard ratios.RESULTS:A total of 1574 patients were included 221 of whom developed central nervous system signs. These signs were spontaneously resolutive. There were 9298person days of follow-up and the overall incidence rate for central nervous system signs was 2.37 per 100 person-days. The variables independently associated with central nervous system anomalies were headache, Adjusted Hazard ratio (AHR) = 1.9(95%CI = 1.4-2.6), bleeding AHR = 2 ((95%CI = 1.3-3.1), P = 0.001, abdominal pain AHR = 1.9 ((95%CI = 1.4-2.6), P<0.001, aches AHR = 2.1 ((95%CI = 1.5-2.9), P<0.001, and fatigue AHR = 1.5 ((95%CI = 1.3-1.7), P<0.001.DISCUSSION:Overall, the present study suggests that neurological signs of dengue are not exceptional even in patients without the most severe features of dengue. These manifestations were spontaneously resolutive. Here it was not possible to distinguish between encephalitis or encephalopathy. Further studies would require more in depth exploration of the patients.
ISSN: 1932-6203

inserm-01421218
http://www.hal.inserm.fr/inserm-01421218
http://www.hal.inserm.fr/inserm-01421218/document
http://www.hal.inserm.fr/inserm-01421218/file/2016%2C%20Djossou%20-%20Incidence%20and%20Predictive%20Factors%20of%20Central%20Nervous%20System%20Dysfunction%20in%20Patients%20Consulting.pdf
DOI : 10.1371/journal.pone.0150828.t003

Éditeur(s) : HAL CCSD
Résumé : International audience
Over the past decade, much attention has been devoted to the development of forest biomass estimation methods at a stand scale, leading to the establishment of allometric models (Chave et al., 2014). These allometric equations use a unique wood specific gravity value (WSG) per species, but neglect the within tree variations of WSG found by others (Wiemann & Williamson, 1989).The main objectives of this study are (1) to illustrate the diversity of radial (from pith to bark) and longitudinal (from bottom to top) patterns of WSG variation within and between species, (2) to highlight different trends of WSG radial variations and the possible misinterpretations of these trends due to the effect of heartwood and (3) to link these variations and patterns to the successional status of the species (from pioneer to sciaphilic species).We sampled 33 small trees (10 Wood sciences underpinning tropical ecology and management. International closing symposium of the XYLAREDD project.
Tervuren, Belgium

hal-01188894
https://hal-sde.archives-ouvertes.fr/hal-01188894

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND: Several studies suggest that exposure to organophosphate insecticides (OP) during pregnancy impairs neurodevelopment in children. OBJECTIVES: We evaluated associations between biomarkers of prenatal and postnatal OP exposure and cognitive function of 6-year-olds in a French longitudinal birth cohort. METHODS: In 2002-2006, the PELAGIE mother-child cohort enrolled pregnant women from Brittany. For a random subcohort, we measured nonspecific dialkylphosphate metabolites (DAP) of OP in one maternal urine sample, collected before 19 weeks' gestation, and in one urine sample collected from their 6-year-old children. Six subtests of the Wechsler Intelligence Scale for Children-4th edition (WISC-IV) was administered at 6 years to evaluate cognitive function (n=231). Linear regression models controlling for factors including maternal intelligence and the Home Observation for Measurement of the Environment score were used. RESULTS: WISC-IV scores were not significantly associated with prenatal or childhood total DAP metabolites. WISC verbal comprehension score was significantly higher in association with the highest maternal urinary concentrations of diethylphosphate metabolites (DE) (5.5; 95% CI: 0.8, 10.3 for extgreater 13.2 nmol/L versus extlessLOQ), while WISC working memory score was significantly lower in association with the highest urinary concentrations of DE metabolites at age 6 years (-3.6; 95% CI: -7.8, -0.6 for extgreater 11.1 nmol/L versus extlessLOD). CONCLUSION: This study found no evidence that prenatal OP exposure adversely affected cognitive function in 6-year-olds, perhaps because of the higher population's socioeconomic status than in previous studies though other causal and non-causal explanations are also possible. The negative association between WISC score and concurrent DE urinary concentrations requires replication by longitudinal studies investigating childhood OP exposure
Environmental Health Perspectives

hal-01207282
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207282
DOI : 10.1289/ehp.1409472
PUBMED : 26394442

Éditeur(s) : HAL CCSD Springer Verlag/EDP Sciences
Résumé : International audience
Context and aim : This study aimed to examine the effect of the tension wood G‐layer on the viscoelastic properties of wood. Methods : Tension wood and opposite wood samples were obtained from six French Guianese tropical rainforest species (Sextonia rubra, Ocotea guyanensis, Inga alba, Tachigali melinoni, Iyranthera sagotiana and Virola michelii); the tension wood of the former three of these species had a Glayer, whilst the tension wood from the latter three had no Glayer. Tensile dynamic mechanical analysis (DMA) was performed on green never dried wood samples in the longitudinal direction with samples submerged in a water bath at a temperature (30°C) and frequency (1 Hz) representative of the conditions experienced by wood within a living tree. Then, DMA was repeated with samples conditioned to an air-dried state. Finally, samples were oven-dried to measure longitudinal shrinkage. Results : Tension wood did not always have a higher longitudinal storage (elastic) modulus than opposite wood from the same tree regardless of the presence or absence of a G‐layer. For the species containing a G‐layer, tension wood had a higher damping coefficient and experienced a greater longitudinal shrinkage upon drying than opposite wood from the same species. No difference was found in damping coefficients between tension wood and opposite wood for the species that had no G‐layer. Conclusion : It is proposed that the different molecular composition of the G-layer matrix has an influence on the viscoelasticity of wood, even if a biomechanical gain is not yet clear. This study shows that rheological properties and longitudinal shrinkage can be used to detect the presence of a G‐layer in tension wood.
ISSN: 1286-4560

hal-00677460
https://hal.archives-ouvertes.fr/hal-00677460
https://hal.archives-ouvertes.fr/hal-00677460/document
https://hal.archives-ouvertes.fr/hal-00677460/file/Clair2.pdf
DOI : 10.1007/s13595-011-0164-1

Éditeur(s) : Inter-Research
Résumé : The species richness pattern of groundfish species in the entire northern Mediterranean Sea was examined at 3 spatial scales: region, large biogeographical zone and basin. We analysed 1914 trawl hauls collected using a single sampling design in the trawlable areas of the continental shelves between the Strait of Gibraltar and the Strait of Dardanelles (from 36.3 to 45.7 degrees N and 5.3 degrees W to 28 E). Spatial pattern in species diversity was assessed using complementary methods (Chao2 estimates of total species richness, mean species richness and beta diversity). No matter which scale was used, the expected longitudinally decreasing trend in species richness, which has been widely described in previous studies, did not appear when comparing estimates of total species richness per unit of area. Only the mean species richness pattern showed a moderate eastwards decrease at the largest spatial scale, but the trend progressively disappeared as the scale of analysis was reduced. In contrast to what is usually expected, our results suggest that Atlantic inflow does not play a key role in the present spatial pattern of fish species richness within the northern Mediterranean Sea. Furthermore, we show that the Aegean Sea can no longer be considered the least species-diverse zone in the northern Mediterranean Sea. Our results provide the first description of a quantitative 'reference state', with which the temporal changes in species richness patterns throughout the entire northern Mediterranean Sea can be compared in the future.
Marine Ecology Progress Series (0171-8630) (Inter-Research), 2007-07 , Vol. 341 , P. 191-203

Droits : 2007 Inter-Research
http://archimer.ifremer.fr/doc/2007/publication-3569.pdf
DOI:10.3354/meps341191
http://archimer.ifremer.fr/doc/00000/3569/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Chlordecone is a persistent organochlorine pesticide that was used in the French West Indies until the early 1990s for banana weevil borer control. Human exposure to this chemical in this area still occurs nowadays due to consumption of contaminated food. Although adverse effects on neurodevelopment, including tremors and memory deficits, have been documented in experimental studies conducted with rodents exposed during the gestational and neonatal periods, no study has been conducted yet to determine if chlordecone alters child development. This study examines the relation of gestational and postnatal exposure to chlordecone to infant development at 18 months of age in a birth-cohort of Guadeloupean children. In a prospective longitudinal study conducted in Guadeloupe (Timoun mother-child cohort study), exposure to chlordecone was measured at birth from an umbilical cord blood sample (n=141) and from a breast milk sample collected at 3 months postpartum (n=75). Toddlers were assessed using an adapted version of the Ages and Stages Questionnaire. Higher chlordecone concentrations in cord blood were associated with poorer fine motor scores. When analyses were conducted separately for boys and girls, this effect was only observed among boys. These results suggest that prenatal exposure to chlordecone is associated with specific impairments in fine motor function in boys, and add to the growing evidence that exposure to organochlorine pesticides early in life impairs child development.
ISSN: 0161-813X

hal-00875907
https://hal.archives-ouvertes.fr/hal-00875907
PUBMED : 23376090
DOI : 10.1016/j.neuro.2013.01.007

Éditeur(s) : HAL CCSD
Résumé : The Earth's magnetic field shows a large range of temporal variations from the year to several million years. I studied during my PhD thesis several aspects of these fluctuations, from recent secular variations to reversals. The first part of my manuscript deals with archeomagnetism, a discipline that allows to track the temporal variations of the Earth's magnetic field through millennia, mainly from archeological materials. I studied two sets of samples , one from Greece (Neolithic period 6800-3200 B.C.) and the other from Mexico (Palenque, Maya Classic period 320-840 A.D.), to acquire new archeointensity data in order to better constrain the secular variation of the geomagnetic field. By comparing my data with those available in the literature and with the various global and regional models, I showed that the secular variations during the Neolithic in Greece and during the first millennium in Central America are poorly defined. My data suggest that local components, not described by global models, may exist in these regions. They reinforce the importance of developing specific regional models. As a consequence, the acquisition of new high quality data is of main importance. The second part presents the description of a geomagnetic field reversal. This work was based on two points : first by studying transitional directions to provide new constraints on the possible preferred longitudinal paths of virtual geomagnetic poles (VGPs) and second by checking transitional paleointensities obtained on a volcanic sequence in Akaroa volcano (New Zealand). Indeed the transitional field intensity is significantly higher than the field intensity before and after the reversal. We re-sampled this sequence, and the directional results show a complex sequence of N-T-R-T-N-T-R polarity. The transitional VGPs obtained are clustered in two longitudinal bands through Australia and America. This observation seems to reinforce the assumption of a core-mantle interaction over several million years. Following a rock magnetic study, I selected samples that could provide a value for the Thellier and multispecimen paleointensity methods. The obtained paleointensity are relatively low (about 20 μT) during the polarity change and strong at the end of the sequence. Based both on the field strength values and on the radiochronological ages, showing that the sequence was erupted in a very short time, I suggest that only the C4AR.1n-C4Ar.1r reversal was recorded in this sequence. In this assumption, the reversal shows a complex path comparable to other reversals recorded in the northern hemisphere (for example the Steens Mountain ), including a rebound before stabilizing. Finally the last part is devoted to the development of a new methodology and a new apparatus to determine absolute paleointensity. Following the low success rate of paleointensity experiments from the previous study, I decided to test the multispecimen protocol, which can be applied to samples yielding a predominant multidomaine behavior. The main technical drawback of this method lies in the application of the laboratory field along the natural remanent magnetization, a difficult task to perform accurately in standard paleointensity ovens. Thus, we decided to adapt sample holders from our standard oven in order to allow the sample orientation in space and to develop an ultra-fast heating oven prototype particularly well-suited for this method, allowing to apply the laboratory field in the 3 dimensions. I checked the different multispecimen protocols on historical lavas from Reunion and Etna volcano, yielding very different magnetic mineralogies. For all flows, I obtained paleointensities very close from the expected values, regardless from the magnetic mineralogy, revealing the feasibility of our apparatus and the promising interest of the method. The application of various corrections on the statistical estimation of the intensity value or on the cooling rate had no significant impact on my results.
La première partie de ma thèse porte sur l'archéomagnétisme, discipline qui permet de retracer l'évolution temporelle du champ magnétique terrestre au travers des derniers millénaires, principalement à partir des matériaux archéologiques. J'ai étudié deux jeux d'échantillons provenant pour l'un de la Grèce (période néolithique, 6800-3200 avant J.C.) et pour l'autre du Mexique (Palenque, période Maya Classique 320-840 après J.C.), dans le but d'acquérir de nouvelles données d'archéointensité et de mieux contraindre la variation séculaire du champ magnétique terrestre. La comparaison de mes données avec celles disponibles dans la bibliographie et avec les différents modèles globaux et régionaux a mis en évidence que les variations séculaires au Néolithique en Grèce et au cours du premier millénaire en Amérique Centrale sont très mal définies. Mes données suggèrent que des composantes locales, non prisent en compte dans les modèles globaux peuvent exister au niveau de ces régions. Elles renforcent l'intérêt de développer des modèles régionaux précis. Pour ce faire, l'acquisition de nouvelles données de haute qualitéest un élément majeur. La deuxième partie traite de la description d'un renversement du champ magnétique terrestre. Cette étude a été basée sur deux points précis : étudier les directions transitionnelles afin d'apporter de nouvelles contraintes sur le possible confinement longitudinal des pôles géomagnétiques virtuels (PGV) d'une part, et d'autre part vérifier des paléointensités transitionnelles obtenues sur la séquence volcanique d'Akaroa (Nouvelle Zélande), dont l'intensité est significativement supérieure à celles des intensités avant et après le renversement. Nous avons ré-échantillonné cette séquence, et l'évolution directionnelle obtenue pour ce renversement est une succession complexe de polarités N-T-R-T-N-T-R. Les PGV obtenus semblent se regrouper sous deux bandes longitudinales sous l'Australie et l'Amérique, ce qui renforce l'hypothèse d'une interaction entre le manteau et le noyau sur plusieurs millions d'années. Suite à une étude de minéralogie magnétique, j'ai sélectionné les échantillons susceptibles de fournir une valeur de paléointensité par les méthodes de Thellier et du multispecimen. Les paléointensités obtenues sont relativement faibles (environ 20 μT) au cours du changement de polarité et forte à la fin de la séquence. Mon interprétation, basée à la fois sur les valeurs de l'intensité du champ et sur les données radiochronologiques montrant que la séquence s'est mise en place très rapidement, est de considérer que seul le renversement C4Ar.1n-C4Ar.1r a été enregistré dans cette séquence. Dans cette hypothèse, le renversement montre un cheminement complexe comparable à d'autres renversements enregistrés dans l'hémisphère nord (comme celui de la Steens Mountain par exemple), incluant un phénomène de rebond avant de se stabiliser. La troisième partie de ma thèse est consacrée au développement d'une nouvelle méthodologie et d'un nouvel appareillage pour déterminer des paléointensités. Le faible taux de réussite des expériences de paléointensité de l'étude précédente m'a poussé à m'intéresser au protocole multispecimen, qui peut s'appliquer aux échantillons possédant un comportement polydomaine. L'inconvénient technique majeur de cette méthode réside dans l'application du champ le long de l'aimantation naturelle, difficile à réaliser avec précision dans les fours standards. Pour ce faire, nous avons décidé de développer des porte-échantillons permettant d'orienter les échantillons dans l'espace pour le four standard et un prototype de four à chauffage ultra-rapide particulièrement bien adapté avec la possibilité d'orienter le champ appliqué dans les 3 dimensions. J'ai testé les différents protocoles de la méthode sur des laves historiques de la Réunion et de l'Etna, possédant des minéralogies très différentes. Pour l'ensemble des coulées étudiées, j'ai obtenu des paléointensités très proches des valeurs attendues, et ce indépendamment de la minéralogie, révélant ainsi le faisabilité de notre appareillage et le côté prometteur de la méthode. L'application de diverses corrections sur la statistique d'estimation de la valeur de l'intensité ou sur le taux de refroidissement n'ont eu aucun impact notable sur mes résultats.
https://tel.archives-ouvertes.fr/tel-00719380

tel-00719380
https://tel.archives-ouvertes.fr/tel-00719380
https://tel.archives-ouvertes.fr/tel-00719380/document
https://tel.archives-ouvertes.fr/tel-00719380/file/thesefanjat2012.pdf

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
Strain and strain rate partitioning in partially molten rocks are two of the important mechanisms that govern the process of coupling and/or decoupling of the partially molten lithosphere. Consequently, the proportion of partial melt and crystals and their network in partially molten rocks influence the degree of the partitioning along with the bulk rheology of the system. This study explores the possible role of finite strain and strain rate on the rate and volume of partial melting and crystallization in a metapelitic system undergoing deformation. Cylinders of synthetic quartz-muscovite aggregate (7: 3 volume ratio) were deformed in torsion at 750 C, 300 MPa and constant shear strain rate ((gamma) over dot = 3 x 10(-4) s(-1)) for finite shear strains (gamma) 1-15. The deformed samples were studied along the longitudinal tangential ( LT) and axial ( LA) sections to obtain the data along a range of strain rates for a given finite strain and vice versa. The results showed that deformation plays an important role on the kinetics of partial melting and crystallization. With increasing strain rate, amount and rate of crystallization comprise the volumetrically dominant process compared to partial melting at a given finite strain. In contrast, when the strain rate is constant, partial melting is the dominant process over crystallization up to moderate strain (gamma < 5). The dominant process reverses at higher strain, and the system shows more crystallization than partial melting. Application of the experimental data to geological systems implies that for metapelites a significant amount (similar to 20%) of partial melt can generate at high strain rate and moderate strain (gamma similar to 7), but at high strain (gamma = 15) the system is melt depleted. Under such conditions, decoupling should take place in brittle-ductile mode. On the other hand, rocks undergoing deformation with low strain rates and strain (gamma < 3) contain more than 25% partial melt, which can act as a major decoupling agent by localizing ductile shear zones.
ISSN: 0148-0227

hal-00617714
https://hal.archives-ouvertes.fr/hal-00617714
DOI : 10.1029/2010JB007865

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
Objective Large-scale prospective studies do not support an association between neuroticism and extroversion with cancer incidence. However, research on other personality constructs is inconclusive. This longitudinal study examined the associations between four personality measures, Type 1, "suppressed emotional expression"; Type 5, "rational/antiemotional"; hostility; and Type A with cancer incidence. Methods Personality measures were available for 13,768 members in the GAZEL cohort study (baseline assessment in 1993). Follow-up for diagnoses of primary cancers was obtained from January 1, 1994 to December 31, 2009. Associations between personality and cancer incidence were evaluated using Cox proportional hazards analyses and adjusted for potential confounders. Results During a median follow-up of 16.0 years (range, 9 days-16 years), 1139 participants were diagnosed as having a primary cancer. The mean duration between baseline and cancer diagnosis was 9.3 years. Type 1 personality was associated with a decreased risk of breast cancer (hazard ratio per standard deviation = 0.81, 95% confidence interval = 0.68-0.97, p = .02). Type 5 personality was not associated with prostate, breast, colorectal, or smoking-related cancers, but was associated with other cancers (hazard ratio per standard deviation = 1.17, 95% confidence interval = 1.04-1.31, p = .01). Hostility was associated with an increased risk of smoking-related cancers, which was explained by smoking habits, and Type A was not associated with any of the cancer endpoints. Conclusions Several personality measures were prospectively associated with the incidence of selected cancers. These links may warrant further epidemiological studies and investigations about potential biobehavioral mechanisms.
ISSN: 0033-3174

inserm-00813178
http://www.hal.inserm.fr/inserm-00813178
http://www.hal.inserm.fr/inserm-00813178/document
http://www.hal.inserm.fr/inserm-00813178/file/PersonalityCancer_Lemogne_Psychosom_Med_2013.pdf
http://www.hal.inserm.fr/inserm-00813178/file/inserm-00813178_edited.pdf

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Background: The objective of the study was to determine the incidence of transaminase elevation during dengue, and its predictive factors. Methods: In 2013, a longitudinal study was performed using data from all cases of dengue seen in Cayenne Hospital. Cox proportional modeling was used. Signs of major transaminase elevation were defined as an increase in aspartate amino transferase (AST) or alanine amino transferase (ALT) concentration over 10 times the normal value (10N). Results: There were 1574 patients and 13 249 person-days of follow-up. The incidence rate for signs of trans-aminase elevation (10N) was 0.55 per 100 person-days. Six patients had major transaminase elevation with AST.1000 units (0.43 per 1000 patient-days), and 73 patients (4.6%) developed transaminase elevation with AST .10N. The variables independently associated with major transaminase elevation were hyponatremia, low platelets, dehydration, hematocrit increase, food intolerance, positive nonstructural protein 1 (NS1), age over 15 years and the notion of paracetamol intake. Conclusions: Although very frequent, the incidence of major transaminase elevation was lower than reported elsewhere perhaps because of good access to care, or of the particular serotype causing this epidemic. The patients with transaminase elevation tended to be older, more severe and taking paracetamol.
ISSN: 0035-9203

inserm-01475594
http://www.hal.inserm.fr/inserm-01475594
http://www.hal.inserm.fr/inserm-01475594/document
http://www.hal.inserm.fr/inserm-01475594/file/2016%2C%20Djossou%20-%20Incidence%20and%20predictive%20factors%20of%20transaminase.pdf
DOI : 10.1093/trstmh/trv117

Résumé : Les pathologies inflammatoires démyélinisantes primitives du système nerveux central (SNC) sont dominées par deux entités : la sclérose en plaques (SEP) et la neuromyélite optique (NMO). Ces deux pathologies se différencient par : 1. leur phénotype, la NMO se caractérisant par une myélite extensive dans le plan transversal et longitudinal et peu de lésions encéphaliques initiales ; 2. leur sévérité, le pronostic de la NMO étant moins bon que celui de la SEP ; 3. leur mécanisme immunologique, puisque l’immunité humorale domine nettement dans la NMO, cette pathologie répondant peu ou pas aux traitementshabituellement prescrits dans la SEP. Un anticorps sérique (IgG-NMO) a été retrouvé chez les patients atteints de NMO avec une sensibilité de 50-70% et une spécificité de 90-100%. Cet anticorps a pour cible le principal canal hydrique du SNC, l’aquaporine-4 (AQP4), qui se situe principalement sur les pieds astrocytaires jalonnant la barrière hémato-encéphalique. La SEP est relativement familière des neurologues car décrite sur le plan épidémiologique et dans son histoire naturelle depuis plus d’un siècle à travers de larges séries réalisées parfois en population générale. Son approche thérapeutique progresse suite à des essais contrôlés qui s’accumulent depuis maintenant près de 20 ans. Toutefois, la majorité des travaux ont été effectués chez les populations Caucasiennes en raison de sa plus grande fréquence dans ces populations. A l’inverse, la NMO garde encore un relatif mystère à cause de sa relative rareté, l’établissement très récent de critères diagnostiques et une physiopathologie très récemment éclaircie par la découverte de l’IgG-NMO qui a indiscutablement suscité un regain d’intérêt de cette affection. Ainsi, son incidence est quasiment inconnue de même que sa susceptibilité génétique. La progression du handicap de la NMO qu’il soit visuel ou moteur à l’évidence sévère, ne repose toujours pas sur des chiffres précis, la description des lésions neuroradiologiques reste encore très embryonnaire. Enfin, même s’il existe un consensus pour traiter énergiquement les poussées de NMO et les espacer, il n’existe quasiment aucune étude prospective.
Introduction: Aim of the study is to describe épidemiology, phenotype and treatment of demyelinating inflammatory diseases of the central nervous system (CNS) namely multiple sclerosis (MS) and neuromyelitis optica (NMO) in French West Indies.Epidemiology: MS emerged in the French West Indian (FWI) population with an incidence of 1.27/100 000 (CI 95%: 1.16-1.38) for the period 1992-2007 while incidence of NMO remained stable at 0.19/100,000 (CI 95%: 0.15–0.23). Both migration in Metropolitean France (MF) and decrease of sun exposure were risk factors for MS acquisition in FWI. Phenotype and treatment of NMO: NMO is a very rapidly disabling disease with median times to reach DSS 3, 6 and 8 of one year, 8 years and 22 years respectively. However, treatment by plasma exchanges were shown to reduce sequellae of NMO attacks ; mitoxantrone and rituximab reduced significantly annualized relapse rate (ARR) from 1.7 to 0.29 (p<10-4) and from 1,34 to 0,56 (p=0.0005) respectively, improving dramatically natural course of NMO.Phenotype and treatment of MS: Absence of Migration in MF in MS patients was found to be the strongest independent predictive factor of disability progression to DSS 6 (hazard ratio, 2.59; p=0.0002); beside short time to DSS3 (p=0.005), later age at onset (p=0.005), and multi-symptomatic onset (p=0.03). Treatment of MS by interferon beta-1 had a moderate impact in MS while natalizimab proved to be highly effective by reducing drastically ARR and inflammatory parameters on magnetic resonance imaging. Conclusion: Spectrum of demyelinating inflammatory disorders of CNS has reversed in French West Indies with overrepresentation of MS. Agressive therapy is needed to improve prognosis of NMO. Rapidly increasing of its incidence makes MS a new public health problem in French West Indies.

http://www.theses.fr/2012AGUY0511/document

Éditeur(s) : Université de Bucarest - Université de Bretagne occidentale
Résumé : This study is focusing on the architecture and recent sedimentary evolution of the Danube channel, the youngest channel-levee system in the Danube deep-sea fan. The study was conducted as part of the BlaSON French-Romanian Project, and combined high-resolution seismic-reflection profiles and chirp profiles with multibeam bathymetry and piston cores. This data set was acquired in 1998 during a joint survey IFREMER-GeoEcoMar of the north-western Black Sea. Previous seismic and acoustic data were also used. The Danube deep-sea fan is a large passive-margin mud-rich fan. Like the other systems of this type (Amazon fan, Mississippi fan or Indus fan) the Danube fan consists of stacked channel-levee systems intercalated with mass-transport deposits. Seismic and sedimentary facies in the Danube fan are similar to those identified in most of the mud-rich systems. Nevertheless, the Danube fan is distinguished by a specific feature: its development in a freshwater environment. This is due to the peculiar water-level history of the Black Sea controlled by the link to the Mediterranean through the Strait of Bosphorus and the Sea of Marmara. This connexion was successively interrupted (during sea level lowstands) and re-established (when the sea level was rising above the Bosphorus). Temporary absence of marine water influx during lowstands together with large freshwater inputs from the Danube and other major rivers changed the Black Sea into a freshwater lake during times of fan activity. This peculiarity possibly favourised the development of hyperpycnal flow at the Danube mouth and the initiation of turbidity currents in the deep-sea fan. The Danube channel is directly connected to the large shelf-indenting Danube canyon (also known as Viteaz canyon). The Danube canyon is deeply incised into the shelf margin for 26 km landward of the shelfbreak. During lowstands this canyon acted as the most important path for sediment supply to the deep sea in this part of the continental margin. It consists of a main trough with steep flanks, and a meandering thalweg cut into the flat canyon floor, attesting for the development of the canyon by erosion in the entrenched axial thalweg. Sections with specific morphology, orientation and gradient identified along the canyon, are interpreted as phases of landward expansion of the canyon. Internal structure of the canyon shows several erosional surfaces, which indicate that the present morphology of the canyon is the result of its polyphasic evolution. Instability in the zone of the canyon is related to the important sediment supply at the Danube mouth, to the presence of the gas in the surficial sediment, and possibly under a structural control. The upper part of the Danube channel (between the Danube canyon and ~1400 m depth) consists in a single leveed-channel that has undergone significant overbank deposition, as attested by the well-developed levees. The levees are strongly asymmetrical, being higher and wider on the right-hand side looking downstream. This type of asymmetry is rather common in deep-sea fans, and is generally attributed to the Coriolis effect (Menard, 1955). The channel is slightly sinuous, partially filled and incised by an entrenched thalweg, connected to the axial thalweg of the Danube canyon. Detailed seismic investigation inside the channel trough documented several depositional phases within the channel fill, separated by erosional surfaces. These surfaces are associated with distinct terraces identified on the multibeam bathymetry, that can be followed downward along the main trough axis. The valley fill deposits (where not removed by the subsequent erosional event) show an axial HAR (High Amplitude Reflections) seismic facies with lateral lower amplitude continuous reflections consisting in a levee facies, as proved by sampling. This indicates that filling up was associated with flow within the channel, and not with interruption of fan activity. On the middle slope below 1400 m, this single channel bifurcates through repeated avulsions. As a result, several highly meandering channels developed. The onlap relationships between these channels indicate that only one channel was active at a time. Each phase of avulsion resulted in a depositional unit consisting in a basal unchannelized lobe defined as High Amplitude Reflection Packets (HARP, Flood et al., 1991) that underlies a channel-levee system. The deposition of HARPs was associated with the readjustment of the longitudinal profile of the channel after the breaching of a levee, which resulted in remobilization of upslope channel deposits and eroded levees. When this adjustment was complete, erosion ceased and levees began to develop above the HARPs (Pirmez et al., 1997). All the identified phases of avulsion followed the same pattern: (1) breaching of the lower and narrower left levee; (2) building of a unit of High Amplitude Reflector Packets (HARP) basinward of the bifurcation point by the unchannelized flow, while the former channel was abandoned; and (3) initiation of a new meandering leveed channel. The northward migration of the resulting units through repeated bifurcations is influenced by the asymmetry between levees (hence by the Coriolis effect), and confined between the high levees of the initial phase of the Danube channel (to the south) and the steep relief of the Dniepr fan (to the north). Structure of the fan valley fill indicate that the erosional surfaces inside the upper channel could be formed in response of successive avulsions, by the adjustment of the longitudinal profile of the channel following the breaching of a levee wall. Sediments removed by erosion formed the HARP lobes basinward of the avulsion point. When this adjustment was complete, a channel-levee system developed downward of the bifurcation, overlying the HARPs, but also upward of this point, as a confined channel-levee system inside the erosional trough of the fan valley. Fluvial incisions identified on the continental shelf, together with the coastline location during the last active period of the Danube channel, indicated that the paleo-Danube was directed towards the head of the Danube canyon. Paleo-Danube mouth was fairly close (ca. 10 km) to the Danube canyon, supplying sediment to the Danube channel. Furthermore, hyperpycnal flow probably prevailed in the freshwater environment that characterized the Black Sea during times of fan activity. These conditions would have enabled the development of a quasi-continuous river-canyon-deep-sea fan system, ensuring the effective transfer of the sediment between the coastal zone and the deep sea.
Ce travail est consacré à l'étude de l'architecture et de l'évolution sédimentaire récente de l'éventail profond du Danube, en particulier de son dernier système chenal-levée: le chenal du Danube. L'étude a été réalisée dans le cadre du projet de coopération franco-roumaine BlaSON, à partir des données sismiques, bathymétriques-acoustiques et sédimentologiques acquises en 1998 lors d'une campagne en mer Noire réalisée par IFREMER et GeoEcoMar. Des données sismiques et acoustiques antérieures ont été également utilisées. L'éventail profond du Danube s'enserre dans la catégorie des grands éventails vaseux. Comme les autres systèmes de ce genre (tel que les éventails de l'Amazone, du Mississippi ou de l'Indus) il est constitué d'une succession de systèmes chenaux-levées intercalés avec des dépôts de transport en masse. Le fonctionnement de l'éventail était conditionné par la baisse du niveau marin lors des périodes glaciaires. Ses faciès sismiques et sédimentaires s'apparentent aux faciès qui caractérisent la plupart des éventails de ce type. L'éventail du Danube constitue néanmoins un cas particulier parmi les autres systèmes étudiés, du fait de son fonctionnement dans un bassin lacustre. Ceci est dû à la situation spécifique de la mer Noire dont la connexion avec la Méditerranée, par le détroit de Bosphore et la mer de Marmara, a été successivement interrompue (au cours de périodes de bas niveau) et reprise (quand le niveau marin remontait en dépassant le seuil du Bosphore). L'absence de l'apport d'eau salée pendant les périodes glaciaires, associée avec l'augmentation de l'apport fluvial, ont déterminé l'installation d'un milieu d'eau douce dans la mer Noire à chaque fois que la baisse du niveau permettait la reprise du fonctionnement de l'éventail profond. Cette situation particulière aurait favorisé la formation des courants hyperpycnaux à l'embouchure d'un fleuve du débit du Danube qui déversait ses eaux turbides dans un bassin lacustre, et aurait donc influencé l'apparition de courants de turbidité dans l'éventail profond. Le chenal du Danube s'est développé sur la pente continentale en prolongation du canyon du Danube (ou Viteaz) auquel il est directement connecté. Le canyon est incisé de manière significative (26 km) dans la plate-forme continentale. Au cours de bas-niveaux marins il constituait la principale voie de transfert des sédiments terrigènes vers le bassin profond dans cette partie de la marge. Le canyon est constitué par une entaille avec des flancs abrupts et un talweg axial incisé, qui montre l'importance du processus d'érosion du fond pour le développement du canyon. Les segments qui ont été identifiés le long du canyon, avec des morphologies, des orientations et des pentes spécifiques, sont interprétés comme des phases d'avancement du canyon vers la côte. Plusieurs incisions sont visibles dans la structure interne du canyon et témoignent que la morphologie actuelle du canyon est le résultat de son évolution polyphasée. L'instabilité de la zone du canyon est en relation avec les apports sédimentaires importants à l'embouchure du Danube, avec la présence du gaz dans les sédiments superficiels, et possiblement sous un contrôle structural. Sur la pente supérieure (entre le canyon du Danube et environ 1400 m de profondeur) le chenal du Danube présente des levées bien développées et fortement asymétriques, avec la levée droite plus haute et plus large que la levée gauche. Ce type d'asymétrie, fréquemment décrit dans les éventails profonds est généralement attribué à l'effet Coriolis (Menard, 1955). Le chenal est légèrement sinueux, partiellement comblé et incisé par un talweg axial qui représente la continuation sur la pente du talweg incisé dans le canyon du Danube. L'analyse sismique détaillée du remplissage de la vallée montre plusieurs phases de dépôt, séparées par des discontinuités érosives. Ces surfaces d'érosion correspondent à des terrasses emboîtées, relativement parallèles le long de la vallée, visibles dans la bathymétrie. Les dépôts qui constituent le remplissage du chenal présentent un faciès sismique de type HAR (High Amplitude Reflections) dans l'axe du chenal, partiellement (ou parfois totalement) enlevé par les phases d'érosion subséquentes, qui continue latéralement avec des réflexions litées correspondant à un faciès sédimentaire de levée. Le remplissage de la vallée a été donc associé avec des écoulements dans le chenal, et non pas avec l'interruption de son fonctionnement. Sur la pente inférieure, le chenal unique bifurque plusieurs fois par avulsion et forme de nouveaux systèmes chenaux-levées méandriformes. Ces systèmes se succèdent verticalement en onlap, ce qui montre qu'un seul chenal a été actif à la fois. Chaque phase d'avulsion a eu comme résultat la mise en place d'une unité constituée par un lobe défini comme "High Amplitude Reflection Packets" (HARP, Flood et al., 1991) à la base, et un système chenal-levée au sommet. Le dépôt d'un lobe HARP est associé avec de l'érosion dans le chenal en amont du point d'avulsion pour l'ajustement de son profil après la rupture de la levée. Quand le chenal a retrouvé son profil d'équilibre, l'érosion a cessé et des levées ont commencé à se développer au-dessus des HARPs (Pirmez et al., 1997). Toutes les phases d'avulsion se sont développées d'après le même modèle: (1) la rupture de la levée gauche, plus étroite; (2) le dépôt d'un lobe HARP par les écoulements non-chenalisés en aval du point d'avulsion, et l'abandon de l'ancien chenal; (3) l'initiation d'un nouveau système chenal-levée. La migration systématique du chenal vers le nord est influencée par l'assymétrie des levées (donc par la force de Coriolis), et confinée entre les grandes levées de la phase initiale du chenal du Danube, au sud, et le relief abrupt de l'éventail du Dniepr au nord. La structure sédimentaire du chenal du Danube indique que les surfaces érosives à l'intérieur du remplissage du chenal se seraient formées en réponse aux avulsions, du fait de l'ajustement du profil du chenal après la rupture d'une levée. Les sédiments du chenal érodés au cours de ce processus ont formé les lobes HARP. Quand le chenal a retrouvé son profil d'équilibre, un système chenal-levée s'est développé en aval du point d'avulsion au dessus du lobe HARP, mais aussi en amont de ce point, où il se trouve confiné dans la vallée érosive. Les incisions fluviatiles identifiés sur la plate-forme continentale et la position de la ligne de côte pendant la dernière période d'activité du chenal du Danube montrent que le paléo-Danube se dirigeait directement vers la tête du canyon du Danube. Son embouchure était située à proximité du canyon, qui alimentait le chenal du Danube. Cependant, les courants hyperpycnaux devaient prévaloir dans le milieu de salinité réduite qui caractérisait la mer Noire lors des périodes actives de l'éventail. Ces conditions auraient favorisé la mise en place d'un système quasi-continu fleuve-canyon-éventail profond, qui contrôlait le transfert des sédiments entre la côte et le bassin profond.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2002/these-1206.pdf
http://archimer.ifremer.fr/doc/00000/1206/

Éditeur(s) : HAL CCSD National Academy of Sciences
Résumé : International audience
Natal philopatry, the return of individuals to their natal area for reproduction, has advantages and disadvantages for animal populations. Natal philopatry may generate local genetic adaptation, but it may also increase the probability of inbreeding that can compromise persistence. Although natal philopatry is well documented in anadromous fishes, marine fish may also return to their birth site to spawn. How philopatry shapes wild fish populations is, however, unclear because it requires constructing multigenerational pedigrees that are currently lacking for marine fishes. Here we present the first multigenerational pedigree for a marine fish population by repeatedly genotyping all individuals in a population of the orange clownfish (Amphiprion percula) at Kimbe Island (Papua New Guinea) during a 10-y period. Based on 2927 individuals, our pedigree analysis revealed that longitudinal philopatry was recurrent over five generations. Progeny tended to settle close to their parents, with related individuals often sharing the same colony. However, successful inbreeding was rare, and genetic diversity remained high, suggesting occasional inbreeding does not impair local population persistence. Local reproductive success was dependent on the habitat larvae settled into, rather than the habitat they came from. Our study suggests that longitudinal philopatry can influence both population replenishment and local adaptation of marine fishes. Resolving multigenerational pedigrees during a relatively short period, as we present here, provides a framework for assessing the ability of marine populations to persist and adapt to accelerating climate change.
ISSN: 0027-8424

hal-01417471
https://hal-univ-perp.archives-ouvertes.fr/hal-01417471
DOI : 10.1073/pnas.1611797113

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Background and Aims: In rain forests, sapling survival is highly dependent on the regulation of trunk slenderness (height/diameter ratio): shade-intolerant species have to grow in height as fast as possible to reach the canopy but also have to withstand mechanical loadings (wind and their own weight) to avoid buckling. Recent studies suggest that mechanosensing is essential to control tree dimensions and stability-related morphogenesis. Differences in species slenderness have been observed among rainforest trees; the present study thus investigates whether species with different slenderness and growth habits exhibit differences in mechanosensitivity. Methods: Recent studies have led to a model of mechanosensing (sum-of-strains model) that predicts a quantitative relationship between the applied sum of longitudinal strains and the plant's responses in the case of a single bending. Saplings of five different neotropical species (Eperua falcata, E. grandiflora, Tachigali melinonii, Symphonia globulifera and Bauhinia guianensis) were subjected to a regimen of controlled mechanical loading phases (bending) alternating with still phases over a period of 2 months. Mechanical loading was controlled in terms of strains and the five species were subjected to the same range of sum of strains. The application of the sum-of-strain model led to a dose-response curve for each species. Dose-response curves were then compared between tested species. Key Results: The model of mechanosensing (sum-of-strain model) applied in the case of multiple bending as long as the bending frequency was low. A comparison of dose-response curves for each species demonstrated differences in the stimulus threshold, suggesting two groups of responses among the species. Interestingly, the liana species B. guianensis exhibited a higher threshold than other Leguminosae species tested. Conclusions: This study provides a conceptual framework to study variability in plant mechanosensing and demonstrated interspecific variability in mechanosensing.
ISSN: 0305-7364

halsde-00454145
https://hal.archives-ouvertes.fr/halsde-00454145
DOI : 10.1093/aob/mcp286

Éditeur(s) : Elsevier Science Bv
Résumé : In this study, the Capbreton canyon head, just off the coast, is investigated using high-resolution multibeam bathymetry datasets, sediment samples and numerical modeling. The HR bathymetry analysis reveals a morphological connection between the longshore trough and the head of the canyon. The analysis of recent sediment samples shows a clear correlation between the sediment of the canyon head and that of the nearshore. Hydrodynamic modeling (a coupled wave-flow model) shows that for high-energy waves, the rotational nature of surf-zone circulation reverses and wave-induced currents have the potential to transport large quantities of nearshore sands toward the canyon head. All these arguments support the assumption that the canyon head captures a part of the sand transported by longshore drift. Over the 15 years of observation (1998–2013), time-lapse bathymetry shows that the floor of the canyon head and one lateral gully network experienced significant morphological reworking. In terms of hazards, despite this strong activity, the position of the canyon head and the profile of its longitudinal slope remained stable and appears as a comforting factor. However, the activity of unusual lateral erosions needs to be monitored.
Marine Geology (0025-3227) (Elsevier Science Bv), 2014-05 , Vol. 351 , P. 1-12

Droits : 2014 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/00180/29118/27524.pdf
DOI:10.1016/j.margeo2014.03.001
http://archimer.ifremer.fr/doc/00180/29118/

Éditeur(s) : HAL CCSD
Résumé : International audience
The environmental uncertainty leads SMEs to adopt collective strategies in order to supplement their inadequate resources. The longitudinal study of the Pic Saint-Loup union of wine producers provides an understanding of how SMEs can develop collective strategies. The case study is based on several time of data collection from mainly forty five semi-structured interviews. Our findings are twofold. We identify the stages of SMEs collective strategies development and the role of stakeholders. Then, we highlight the tertius strategies of SMEs owner-managers and the positive influence of their combination.
Les PME, plus vulnérables aux forces de l'environnement, cherchent à compléter l'insuffisance de leurs ressources en adoptant des stratégies collectives afin de réduire cette incertitude. L'étude longitudinale du syndicat de producteurs de vin du Pic Saint-Loup, qui s'appuie sur plusieurs temps de collecte et quarante-cinq entretiens semi-directifs, permet de comprendre la façon dont des PME peuvent développer des stratégies collectives. Nous identifions les phases du développement de la stratégie collective ainsi que le rôle joué par les parties prenantes. Puis, nous soulignons les stratégies de tertius des dirigeants de PME et leur combinaison favorisant le développement de ces stratégies collectives. Mots clés : Stratégie collective, PME, étude longitudinale, parties prenantes, tertius. *Remerciements Ce papier bénéficie du soutien de la chaire Entrepreneuriat et Innovation du 'Labex Entreprendre' de Montpellier en France. Ce " laboratoire d'excellence " est reconnu et soutenu par le gouvernement français pour la qualité de ses recherches dans les sciences humaines et sociales.
Management International / International Management / Gestión Internacional

hal-01588177
http://hal.univ-smb.fr/hal-01588177
http://hal.univ-smb.fr/hal-01588177/document
http://hal.univ-smb.fr/hal-01588177/file/MI-710%20-%20GRANATA%20DA%20FONSECA%20MARQU%C3%88S%20G%C3%89RAUDEL.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In this study, we report the cloning of three transcripts for leptin receptor in the European sea bass, a marine teleost of economic interest. The two shortest variants, generated by different splice sites, encode all functional extracellular and intracellular domains but missed the transmembrane domain. The resulting proteins are therefore potential soluble binding proteins for leptin. The longest transcript (3605 bp), termed sblepr, includes all the essential domains for binding and transduction of the signal. Thus, it is proposed as the ortholog for the human LEPR gene, the main responsible for leptin signalling. Phylogenetic analysis shows the sblepr clustered within the teleost leptin receptor group in 100% of the bootstrap replicates. The neuroanatomical localization of sblepr expressing cells has been assessed by in situ hybridization in brains of sea bass of both sexes during their first sexual maturation. At histological level, the distribution pattern of sblepr expressing cells in the brain shows no clear differences regarding sex or reproductive season. Transcripts of the sblepr have a widespread distribution throughout the forebrain and midbrain until the caudal portion of the hypothalamus. A high hybridization signal is detected in the telencephalon, preoptic area, medial basal and caudal hypothalamus and in the pituitary gland. In a more caudal region, sblepr expressing cells are identified in the longitudinal torus. The expression pattern observed for sblepr suggests that in sea bass, leptin is very likely to be involved in the control of food intake, energy reserves and reproduction
ISSN: 0016-6480

hal-01290500
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500/file/Leptin%20receptor%20gene%20in%20the%20European%20sea%20bass%20postprint.pdf
DOI : 10.1016/j.ygcen.2016.03.017

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We analyze in this study a new set of marine data including 3D local tomography, 1992-2008 relocated earthquakes and two recent multichannel seismic lines to characterize the deformation style in the collision area offshore east Taiwan. We have mapped in detail the Mohos of the converging plates as well as the subduction interface with a resolution never reached before. We show that the sharp continental subduction of the Eurasia plate, beneath the middle part of the Central Range, indents the Philippine Sea plate (PSP) as attested by intra-oceanic slicing and incipient subduction of the PSP beneath the east coast of Taiwan. The westernmost part of the PSP slab is probably experiencing a beginning of break-off as attested by NW-trending en-échelon shear zones beneath the southern slope of the southern Ryukyu arc (SRA). These en-échelon shear zones have a sinistral component favored by the "collision-free" subduction of the PSP north of 24°30′N. The down-faulting of the subduction interface forms ramps along which earthquakes clusterize. Three M7 subduction earthquakes occurred offshore Suao city along these ramps with a recurrence interval of about 40 years: 1920 Mw7.7, 1963 Mw7.2 and 2002 Mw7.1 events. The 1966 Mw6.0-7.5 earthquakes sequence likely outlines a WNW-ESE left-lateral intra-slab shear zone. The SRA upper plate accommodates the complex geometry and deformation of the subducting PSP through seismic deformation. Shallow high velocities fringing the Luzon volcanic arc (LVA) beneath the Longitudinal Valley and north of the southernmost Ryukyu forearc basins are interpreted as relics of the LVA forearc basement squeezed in the collision zone. Based on the accommodation of a large part of the convergence through shortening within the PSP and the subsequent segmentation of the shallow subduction interface, we consider that the nucleation of a Mw ≥ 8 earthquake along the southernmost Ryukyu megathrust is unlikely.
ISSN: 0040-1951

hal-00853365
https://hal.archives-ouvertes.fr/hal-00853365
https://hal.archives-ouvertes.fr/hal-00853365/document
https://hal.archives-ouvertes.fr/hal-00853365/file/publallemandifremer.pdf
DOI : 10.1016/j.tecto.2013.03.020

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Due to their geographic location and traditional diet, rich in seafood and marine mammals, the Inuit living in Arctic Quebec are exposed to high amounts of pollutants, including organochlorine pesticides (OCPs). While the adverse developmental effects of these pesticides on child cognitive functions are well known, the effects of developmental exposure to OP on sensory processes have not been investigated. The aim of this longitudinal study was to assess the effects of prenatal and childhood exposure to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT) and its major metabolite 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), on visual processing in Inuit children in Nunavik (Arctic Québec). p,p'-DDT and p,p'-DDE concentrations were determined from umbilical cord and 5- and 11-year plasma samples. Visual evoked potentials (VEPs) were successfully recorded in 150 children at 4 contrast levels (95%, 30%, 12%, and 4%). Hierarchical multiple regressions were conducted to determine the association between p,p'-DDT, or p,p'-DDE, exposure and VEPs while controlling for the effects of various confounders, including fish nutrients and other contaminants. p,p'-DDE measured in umbilical cord plasma was significantly related to the amplitude of the N150 response at the lowest contrast (4%). In addition, 5-year p,p'-DDE plasma concentration was significantly associated with decreased N75 amplitude. These findings indicate that p,p'-DDE exposure, both pre- and postnatally, during early childhood is associated with visual processing impairment later in life.
ISSN: 0161-813X

hal-01061309
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061309
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061309/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061309/file/Prenatal_and_5-year-NEUTOX-D-13-00192R2_v4.pdf
DOI : 10.1016/j.neuro.2014.04.009

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Local variation in the density of Anopheles mosquitoes and the risk of exposure to bites are essential to explain the spatial and temporal heterogeneities in the transmission of malaria. Vector distribution is driven by environmental factors. Based on variables derived from satellite imagery and meteorological observations, this study aimed to dynamically model and map the densities of Anopheles darlingi in the municipality of Saint-Georges de l’Oyapock (French Guiana). Longitudinal sampling sessions of An. darlingi densities were conducted between September 2012 and October 2014. Landscape and meteorological data were collected and processed to extract a panel of variables that were potentially related to An. darlingi ecology. Based on these data, a robust methodology was formed to estimate a statistical predictive model of the spatial-temporal variations in the densities of An. darlingi in Saint-Georges de l’Oyapock. The final cross-validated model integrated two landscape variables—dense forest surface and built surface—together with four meteorological variables related to rainfall, evapotranspiration, and the minimal and maximal temperatures. Extrapolation of the model allowed the generation of predictive weekly maps of An. darlingi densities at a resolution of 10-m. Our results supported the use of satellite imagery and meteorological data to predict malaria vector densities. Such fine-scale modeling approach might be a useful tool for health authorities to plan control strategies and social communication in a cost-effective, targeted, and timely manner.
ISSN: 1932-6203

hal-01383486
https://hal.archives-ouvertes.fr/hal-01383486
https://hal.archives-ouvertes.fr/hal-01383486/document
https://hal.archives-ouvertes.fr/hal-01383486/file/Adde_et_al_PlosONE_2016.pdf
DOI : 10.1371/journal.pone.0164685