Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study aimed to identify factors associated with virological response (VR) to raltegravir (RAL)-containing regimens in 468 treatment-experienced but integrase inhibitor-naive HIV-1 patients receiving a RAL-containing regimen. VR was defined at Month 6 (M6) as HIV-1 RNA viral load (VL) <50 copies/mL. The impacts on VR of baseline integrase mutations, VL, CD4 count, genotypic sensitivity score for nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors, and the number of new antiretrovirals used for the first time associated with RAL were investigated. For patients with VL >50 copies/mL at M6, integrase mutations selected were characterised. Median baseline VL was 4.2 log(10)copies/mL (IQR 3.3-4.9 log(10) copies/mL) and CD4 count was 219 cells/mm(3) (IQR 96-368 cells/mm(3)). At M6, 71% of patients were responders. In multivariate analysis, baseline VL and CD4 count and ≥ 2 new antiretrovirals among darunavir, etravirine, maraviroc and enfuvirtide were associated with VR to RAL. Neither HIV-1 subtype nor baseline integrase polymorphisms were associated with VR to RAL. Among 63 failing patients at M6, selection of ≥ 1 change in the integrase gene was observed in 49 (77.8%), and 27/63 (42.9%) were considered as RAL-associated resistance mutations. Factors independently associated with the occurrence of ≥ 1 RAL-associated resistance mutation were VL at failure >3 log(10) and having no new drugs associated with RAL. RAL showed great potency in treatment-experienced patients. The number of new drugs associated with RAL was an important factor associated with VR. HIV-1 subtype and baseline integrase polymorphisms do not influence the RAL VR.
ISSN: 0924-8579

hal-00875083
https://hal.archives-ouvertes.fr/hal-00875083
DOI : 10.1016/j.ijantimicag.2013.02.016
PUBMED : 23562640

Éditeur(s) : HAL CCSD
Résumé : International audience
Fish is a rich source of essential nutrients for fetal development, but in contrast, it is also a well-known route of exposure to environmental pollutants. We assessed whether fish intake during pregnancy is associated with fetal growth and the length of gestation in a panel of European birth cohort studies. The study sample of 151,880 mother-child pairs was derived from 19 population-based European birth cohort studies. Individual data from cohorts were pooled and harmonized. Adjusted cohort-specific effect estimates were combined by using a random- and fixed-effects meta-analysis. Women who ate fish >1 time/wk during pregnancy had lower risk of preterm birth than did women who rarely ate fish (≤ 1 time/wk); the adjusted RR of fish intake >1 but <3 times/wk was 0.87 (95% CI: 0.82, 0.92), and for intake ≥ 3 times/wk, the adjusted RR was 0.89 (95% CI: 0.84, 0.96). Women with a higher intake of fish during pregnancy gave birth to neonates with a higher birth weight by 8.9 g (95% CI: 3.3, 14.6 g) for >1 but <3 times/wk and 15.2 g (95% CI: 8.9, 21.5 g) for ≥ 3 times/wk independent of gestational age. The association was greater in smokers and in overweight or obese women. Findings were consistent across cohorts. This large, international study indicates that moderate fish intake during pregnancy is associated with lower risk of preterm birth and a small but significant increase in birth weight.
The American Journal of Clinical Nutrition

hal-01118513
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118513
PUBMED : 24335057
DOI : 10.3945/ajcn.113.067421

Éditeur(s) : HAL CCSD Seismological Society of America
Résumé : International audience
Abstract The continuous record of large surface-rupturing earthquakes along the Dead Sea fault brings unprecedented insights for paleoseismic and archaeoseismic research. In most recent studies, paleoseismic trenching documents the late Holocene faulting activity, while tectonic geomorphology addresses the long-term behavior (>10 ka), with a tendency to smooth the effect of individual earthquake rupture events (Mw >7). Here, we combine historical, archaeological, and paleoseismic investigations to build a consolidated catalog of destructive surface-rupturing earthquakes for the last 14 ka along the left-lateral Jordan Valley fault segment. The 120- km-long fault segment limited to the north and the south by major pull-apart basins (the Hula and the Dead Sea, respectively) is mapped in detail and shows five subsegments with narrow stepovers (width < 3 km). We conducted quantitative geomorphology along the fault, measured more than 20 offset drainages, excavated four trenches at two sites, and investigated archaeological sites with seismic damage in the Jordan Valley. Our results in paleoseismic trenching with 28 radiocarbon datings and the archaeoseismology at Tell Saydiyeh, supplemented with a rich historical seismic record, document 12 surface-rupturing events along the fault segment with a mean interval of ∼1160 yr and an average 5 mm=yr slip rate for the last 25 ka. The most complete part of the catalog indicates recurrence intervals that vary from 280 yr to 1500 yr, with a median value of 790 yr, and suggests an episodic behavior for the Jordan Valley fault. Our study allows a better constraint of the seismic cycle and related short-term variations (late Holocene) versus long-term behavior (Holocene and late Pleistocene) of a major continental transform fault.
ISSN: 0037-1106

hal-00747401
https://hal.archives-ouvertes.fr/hal-00747401
DOI : 10.1785/0120100097

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide a unified interface to biomedical databases that are distributed worldwide. The portal provides access to numerous database projects supported by 30 scientific organizations. It includes over 800 different biological datasets spanning genomics, proteomics, model organisms, cancer data, ontology information and more. All resources available through the portal are independently administered and funded by their host organizations. The BioMart data federation technology provides a unified interface to all the available data. The latest version of the portal comes with many new databases that have been created by our ever-growing community. It also comes with better support and extensibility for data analysis and visualization tools. A new addition to our toolbox, the enrichment analysis tool is now accessible through graphical and web service interface. The BioMart community portal averages over one million requests per day. Building on this level of service and the wealth of information that has become available, the BioMart Community Portal has introduced a new, more scalable and cheaper alternative to the large data stores maintained by specialized organizations.
ISSN: 0305-1048

hal-01146849
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146849
DOI : 10.1093/nar/gkv350
PUBMED : 25897122

Éditeur(s) : HAL CCSD
Résumé : 1 p.
AGU, Fall Meeting 2008
San Francisco, United States

insu-00375967
https://hal-insu.archives-ouvertes.fr/insu-00375967

Éditeur(s) : HAL CCSD Magnolia Press
Résumé : International audience
A new species of the genus Cocconeis is described. Cocconeis sawensis sp. nov. was observed as epiphyte on the macrophyte Chara Linn. sp., collected from a saline lake in Iraq (Sawa Lake). Description of the new species is based on details observed with light and scanning electron microscopy. Cocconeis sawensis belongs to a group of taxa similar to Cocconeis euglypta Ehrenberg, but differs in a number of fine ultrastructural features including stria density and hymenes, raphe, valve shape and rim, valvocopula, hymen perforations and fimbriae shape as well as a presence of a pore-like structure reminiscent of a vestigial raphe in the sternum valve. A comparison with closely related taxa is given.
ISSN: 1179-3155

hal-01296895
https://hal-univ-perp.archives-ouvertes.fr/hal-01296895
DOI : 10.11646/phytotaxa.181.4.2

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Up to now, several studies have investigated estrogen receptor (ER)–estrogen response element (ERE) interaction using biosensors such as surface plasmon resonance. These strategies have aimed to understand the molecular mechanism of such interaction as well as the effect of the ligand on this interaction. These approaches start to be used to determine the mechanisms of protein/DNA interaction, in particular in the context of drug discovery or environmental applications. However, some physical and biochemical parameters (incubation time, temperature, protease inhibitor cocktail, and bovine serum albumin (BSA)) are not completely described in the literature and could deeply modify the obtained results. This paper aims to focus not only on the preliminary steps of sample preparation such as protein thawing and incubation conditions (time and temperature) but also on the evaluation of protease inhibitor cocktail and BSA effect on the measurement of ER–ERE interactions.
ISSN: 1618-2642

hal-01418341
https://hal.archives-ouvertes.fr/hal-01418341
https://hal.archives-ouvertes.fr/hal-01418341/document
https://hal.archives-ouvertes.fr/hal-01418341/file/Estrogen%20Receptor%20preparation%20effects_accepted.pdf
DOI : 10.1007/s00216-016-9967-0

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
Continental rifts and passive continental margins show fundamental along-axis segmentation patterns that have been attributed to one or a number of different processes: extensional fault geometry, variable stretching along strike, preexisting lithospheric compositional and structural heterogeneities, oblique rifting, and the presence or absence of eruptive volcanic centers. The length and width scales of the rift stage fault-bounded basin systems change during the late evolution of the new plate boundary, and the role of magmatism may increase as rifting progresses to continental rupture. Along obliquely spreading ridges, first-order mid-ocean ridge geometries originate during the synrift stage, indicating an intimate relationship between magma production and transform fault spacing and location. The Gulf of Aden rift is a young ocean basin in which the earliest synrift to breakup structures are well exposed onshore and covered by thin sediment layers offshore. This obliquely spreading rift is considered magma-poor and has several large-offset transforms that originated during late stage rifting and control the first-order axial segmentation of the spreading ridge. Widely spaced geophysical transects of passive margins that produce only isolated 2-D images of crust and uppermost mantle structure are inadequate for evaluation of competing rift evolution models. Using closely spaced new geophysical and geological observations from the Gulf of Aden we show that rift sectors between transforms have a large internal variability over short distances (∼10 km): the ocean-continent transition (OCT) evolves from a narrow magmatic transition to wider zones where continental mantle is probably exhumed. We suggest that this small-scale variability may be explained (1) by the distribution of volcanism and (2) by the along-strike differences in time-averaged extension rate of the oblique rift system. The volcanism may be associated with (1) the long-offset Alula-Fartak Fracture Zone, which may enhance magma production on its younger side, or (2) channeled flow from the Afar plume material along the newly formed OCT and the spreading ridge. Oblique extension and/or hot spot interactions may thereby have a significant control on the styles of rifting and continental breakup and on the evolution of many magma-poor margins.
ISSN: 1525-2027

hal-00504866
https://hal.archives-ouvertes.fr/hal-00504866
https://hal.archives-ouvertes.fr/hal-00504866/document
https://hal.archives-ouvertes.fr/hal-00504866/file/G3-Leroy_al-2010.pdf
DOI : 10.1029/2009GC002963

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Sponges are a rich source for investigation of bioactive small molecules. They have been mostly investigated for the search of new pharmacological models or therapeutic agents for the treatment of human diseases. Micro-organisms can also represent a virulent pathogen for marine invertebrates such as sponges, which need to protect themselves against these microbes. Sponges' self defence mechanisms involving dialogue molecules thus represent a pertinent research track for potent anti-infective and anti-biofilm activities such as quorum sensing inhibitors (QSIs). The investigation of the QSI crude extract of Leucetta chagosensis Dendy, 1863 led to the isolation of three new alkaloids, isonaamine D, di-isonaamidine A and leucettamine D, along with the known isonaamine A and isonaamidine A. Isonaamidine A and isonaamine D were identified as inhibitors of the three quorum sensing pathways of Vibrio harveyi (CAI-1, AI-2 and harveyi auto inducer), but isonaamidine A displayed the strongest activity on AI-2 biosensor. Both compounds are new examples of natural QSIs of V. harveyi. These results outline the importance of these secondary metabolites for their producing organisms themselves in their natural environment, as well as the potential of the marine resource for aquaculture needs.
ISSN: 0266-8254

hal-01684926
https://hal.archives-ouvertes.fr/hal-01684926
DOI : 10.1111/lam.12461
PUBMED : 26138555

Éditeur(s) : HAL CCSD
Résumé : The Neogene geodynamics evolution of the south-Alboran realm in western Mediterranean has been clarified, based on sedimentological and chronostratigraphical studies. This work focuses on three main themes of research, the first is to establish the moments for the opening and closing of the North Rifian Corridor by studying two Neogene basins of the southern edge of the Alboran sea. The second, aims to understand the behavior of these two basins face a major event in the history of the Mediterranean: The Messinian Salinity Crisis. Finally, the third theme aims to understand the modalities Post-MSC reflooding in the southern part of the Alboran realm.The late Miocene evolution of the North Rifian Corridor is clarified on the basis of chronostratigraphic studies of the Neogene Boudinar and Arbaa Taourirt basins (northeastern Morocco). The marine sediments deposited in the Boudinar basin between the early Tortonian and the late early Messinian (10 Ma to 6.1 Ma) and in the late Tortonian-earliest Messinian interval in the Arbaa Taourirt basin. Palaeoenvironmental data record a major drowning in association with extensive tectonics in the Boudinar basin during the early Messinian at ~7.2 Ma. At the same time, prograding conglomerates and sandstones developed over the late Tortonian marls in the Arbaa Taourirt basin. During the late-early Messinian, a shallowing trend occurred in the Boudinar basin. Thus, the North Rifian Corridor opened at ~7.2 Ma ensuring Atlantic-Mediterranean connections, then was progressively restricted during the late-early Messinian and totally closed at ~6.1 Ma. New sedimentological and paleontological studies of the late Messinian-early Pliocene deposits in the Boudinar basin provide new information on the Messinian Salinity Crisis (« MSC ») and the Zanclean reflooding in the Alboran sea. The Messinian erosional surface « MES » is of late Messinian age and was emplaced in subaerial settings. It is polygenic, its original geometry is locally preserved and was re-shaped by the Pliocene transgressive surface. Above the « MES », the Boudinar basin infill is characterized by a wide variety of facies from continental settings to lower offshore conditions. Two major sets are recognized: a latest Messinian-Zanclean set that constitutes a transgressive-regressive megasequence interrupted at the top by a tectonic unconformity, and an Plio-Quaternary regressive set. During the late Messinian Zanclean interval, four successive depositional models were documented. They record major changes in palaeoflow and paleogeography related to base-level fluctuations. No Gilbert-type delta has ben identified at Boudinar. the beginning of base-level rise is marked by normal regressions and by the formation of several lacs and fan-delta complexes on the margins of the basin in the late Messinian and befor the marine reefloding in the early Zanclean. The marine reflooding of the basin appears later, with a transgressive surface of ravinment and a thick package of transgressive deposits. These transgressive deposits onlap over all previous deposits. The major part of the basin infill did not issue from an inner landward position (south of the basin) but from the northwestern side of the basin, i.e. near the Mediterranean. Sediments were subsequently reworked by storms and transported by longshore-drift towards the south. a maximum flooding surface is found several tens of metres above the « MES ». This fiding is consistent with a progressive and not a catastrophic early Zanclean flooding of the westernMediterranean after the Mediterranean base-level fall.
Sur la base d’études sédimentologiques et chronostratigraphiques dans les bassins de Boudinar et d’Arbaa Taourirt (Rif oriental, Maroc), l’évolution géodynamique néogène du domaine sud-Alboran en Méditerranée occidentale a été clarifiée. Ce travail est axé sur trois grandes thématiques de recherche. La première vise à l’établissement d’un cadre chronostratigraphique pour l’ouverture et la fermeture du Couloir Nord Rifain, par l’étude de deux bassins nèogènes de la bordure sud de la mer d’Alboran. La deuxième, vise à comprendre le comportement de ces deux bassins face à un événement majeur de l’histoire de la Mediterranée : la Crise de salinité messinienne. Finalement, la troisième vise à comprendre les modalités de remise en eau de la Méditerranée après la Crise : le reenoiement pliocène. L'évolution du Couloir Nord Rifain au Miocène supérieur est clarifiée sur la base des études chronostratigraphiques des bassins néogènes de Boudinar et d'Arbaa Taourirt (Maroc Nord oriental). Les sédiments marins miocènes se sont déposés entre le Tortonien inférieur et le Messinien inférieur (10 à 6.1 Ma) dans le bassin de Boudinar et entre le Tortonien supérieur et le Messinien inférieur dans le bassin d'Arbaa Taourirt. Les données paléoenvironnementales enregistrent un ennoyage important du bassin de Boudinar en relation avec une tectonique extensive pendant le Messinien inférieur (~7.2 Ma). En même temps, des conglomérats et de grès progradants se sont développés au-dessus des marnes tortoniennes dans le bassin d’Arbaa Taourirt. Le bassin de Boudinar a subi un désapprofondissement au Messinien inférieur. Ces résultats indiquent que le Couloir Nord Rifain s’est ouvert à ~7.2 Ma assurant les communications entre l’Atlantique et la Méditerranée, puis a subi une restriction progressive pendant le Messinien inférieur avant d’être totalement fermé à ~6.1 Ma.De nouvelles études sédimentologiques et paléontologiques des dépôts Messinien supérieur-Pliocène inférieur dans le bassin de Boudinar fournissent des informations sur la Crise de salinité messinienne (« MSC ») et le réennoiement zancléen dans la Mer d'Alboran. L’un des marqueurs majeurs de la Crise est identifié : la surface d’érosion messinienne « MES ». Elle est d'âge Messinien supérieur et a été mise en place dans des conditions subaériennes. Sa géométrie originale n’est préservée que localement et a été remodelée par la surface transgressive du Pliocène inférieur. Au dessus de la « MES » le remplissage sédimentaire du bassin de Boudinar est caractérisé par une grande variété de faciès allant des conditions de dépôts continentales jusqu’à des conditions d’offshore inférieur. Deux ensembles majeurs sont reconnus : un ensemble messinien terminal-zancléen qui constitue une mégaséquence transgressive-regressive, interrompue au sommet par une discordance tectonique, et un ensemble plio-quaternaire regressif. Durant l’intervalle Messinien terminal-Zancléen, quatre modèles de dépôts successifs ont été documentés enregistrant des changements majeurs de paléocourants et de paléogéographies, liés aux fluctuations de niveau de base. Nous n’avons pas identifié de Gilbert delta à Boudinar. La remontée du niveau de base est marquée par une régression normale et par le développement des lacs et de complexes de fan-deltas sur les marges du bassin pendant le Messinien supérieur, avant l’inondation marine au Zancléen basal. Le réennoiement marin du bassin apparait plus tard avec une surface de transgression ravinante et par d’épais dépôts transgressifs, en onlap sur tous les dépôts précédents. La majeure partie du remplissage sédimentaire du bassin n’est pas reçue des reliefs de la bordure sud du bassin, mais du côté Nord-Ouset au bord de la Méditerranée. Les sédiments sont alors remaniés par les tempêtes et transportés vers le sud par la dérive littorale. Une surface d’inondation maximale a été identifiée à plusieurs dizaines de mètres au-dessus de la « MES ». Ceci suggère un ennoiement progressif et non catastrophique, après la chute du niveau de base méditerranéen.
https://tel.archives-ouvertes.fr/tel-01473572

Droits : http://hal.archives-ouvertes.fr/licences/copyright/
tel-01473572
https://tel.archives-ouvertes.fr/tel-01473572
https://tel.archives-ouvertes.fr/tel-01473572/document
https://tel.archives-ouvertes.fr/tel-01473572/file/Th%C3%A8se-achalhi.pdf

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
Les risques hydrométéorologiques sont au coeur du programme de recherche HyMeX sur le cycle de l'eau en Méditerranée. HyMeX a pour ambition d'améliorer leur prévision, de mieux connaître leur variabilité à l'échelle pluriannuelle et de renseigner sur leur évolution, dans le contexte du changement climatique. À cette fin, deux campagnes de mesures dédiées à ces événements extrêmes (SOP1 : pluies intenses et crues rapides ; SOP2 : vents forts et formation d'eaux denses) sont organisées en Méditerranée nord-occidentale, entre septembre 2012 et mars 2013.
ISSN: 0026-1181

hal-00829760
https://hal.archives-ouvertes.fr/hal-00829760
DOI : 10.4267/2042/48793

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Few studies have explored the consequences of environmental exposure to organochlorine pesticides for gestational hypertension (GH), preeclampsia (PE) and gestational diabetes mellitus (GDM). Chlordecone is a persistent organochlorine pesticide that was used intensively, and almost exclusively, in the French West Indies until 1993. We investigated the impact of prenatal exposure to chlordecone on the occurrence of GDM, GH and PE by studying 779 pregnant women enrolled in a prospective mother-child cohort (Timoun Study) in Guadeloupe between 2004 and 2007. Chlordecone exposure was determined by assaying maternal plasma and information about pregnancy complications was obtained from midwives, pediatricians and hospital medical records after delivery. The risks of GH (n=65), PE (n=31) and GDM (n=71) were estimated by multiple logistic regression including potential confounders. Levels of chlordecone plasma concentration in the third (OR=0.2; 95% confidence interval (CI): 0.1, 0.5) and fourth quartiles (OR=0.3; 95% CI: 0.2, 0.7) were associated with a statistically significant decrease in the risk of GH. A log10 increase in chlordecone concentration was significantly associated with lower risk of GH (OR=0.4; 95% CI: 0.2, 0.6). No significant associations were observed between the chlordecone exposure and the risk of PE or GDM. This study suggests an inverse association between chlordecone exposure during pregnancy and GH. Further studies are required to determine the underlying mechanism, or the potential unknown confounding factors, resulting in this association.
ISSN: 0160-4120

hal-01061391
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061391
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061391/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061391/file/Saunders_et_al._Final_version_main_manuscript.pdf
DOI : 10.1016/j.envint.2014.03.024

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
We analyse P-wave receiver functions across the western Gulf of Aden and southern Red Sea continental margins in Western Yemen to constrain crustal thickness, internal crustal structure and the bulk seismic velocity characteristics in order to address the role of magmatism, faulting and mechanical crustal thinning during continental breakup. We analyse teleseismic data from 21 stations forming the temporary Young Conjugate Margins Laboratory (YOCMAL) network together with GFZ and Yemeni permanent stations. Analysis of computed receiver functions shows that (1) the thickness of unextended crust on the Yemen plateau is ∼35km; (2) this thins to ∼22km in coastal areas and reaches less than 14km on the Red Sea coast, where presence of a high-velocity lower crust is evident. The average Vp/Vs ratio for the western Yemen Plateau is 1.79, increasing to ∼1.92 near the Red Sea coast and decreasing to 1.68 for those stations located on or near the granitic rocks. Thinning of the crust, and by inference extension, occurs over a ∼130-km-wide transition zone from the Red Sea and Gulf of Aden coasts to the edges of the Yemen plateau. Thinning of continental crust is particularly localized in a <30-km-wide zone near the coastline, spatially co-incident with addition of magmatic underplate to the lower crust, above which on the surface we observe the presence of seaward dipping reflectors (SDRs) and thickened Oligo-Miocene syn-rift basaltic flows. Our results strongly suggest the presence of high-velocity mafic intrusions in the lower crust, which are likely either synrift magmatic intrusion into continental lower crust or alternatively depleted upper mantle underplated to the base of the crust during the eruption of the SDRs. Our results also point towards a regional breakup history in which the onset of rifting was synchronous along the western Gulf of Aden and southern Red Sea volcanic margins followed by a second phase of extension along the Red Sea margin.
ISSN: 0956-540X

hal-00825194
https://hal.archives-ouvertes.fr/hal-00825194
https://hal.archives-ouvertes.fr/hal-00825194/document
https://hal.archives-ouvertes.fr/hal-00825194/file/RF_Hakim2012_GJI.pdf
DOI : 10.1093/gji/ggt072

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: The genetic diversity of Plasmodium falciparum has been extensively studied in various parts of the world. However, limited data are available from Mauritania. The present study examined and compared the genetic diversity of P. falciparum isolates in Mauritania. METHODS: Plasmodium falciparum isolates blood samples were collected from 113 patients attending health facilities in Nouakchott and Hodh El Gharbi regions. K1, Mad20 and RO33 allelic family of msp-1 gene were determined by nested PCR amplification. RESULTS: K1 family was the predominant allelic type carried alone or in association with Ro33 and Mad20 types (90%; 102/113). Out of the 113 P. falciparum samples, 93(82.3%) harboured more than one parasite genotype. The overall multiplicity of infection was 3.2 genotypes per infection. There was no significant correlation between multiplicity of infection and age of patients. A significant increase of multiplicity of infection was correlated with parasite densities. CONCLUSIONS: The polymorphism of P. falciparum populations from Mauritania was high. Infection with multiple P. falciparum clones was observed, as well as a high multiplicity of infection reflecting both the high endemicity level and malaria transmission in Mauritania.
ISSN: 1475-2875

inserm-00936407
http://www.hal.inserm.fr/inserm-00936407
http://www.hal.inserm.fr/inserm-00936407/document
http://www.hal.inserm.fr/inserm-00936407/file/1475-2875-13-26.pdf
DOI : 10.1186/1475-2875-13-26

Éditeur(s) : HAL CCSD
Résumé : National audience
La Zone Nord-Pyrénéenne (ZNP) résulte de l’inversion debassins albo-cénomaniens ouverts entre les plaques Europe etIbérie. Le manteau subcontinental a été exhumé dans le fond decertains de ces bassins et la couverture sédimentaire mésozoïquepré-rift, désolidarisée du soubassement paléozoïque, est venue localementen contact tectonique avec les péridotites. Ceci faitde la ZNP un analogue pour l’étude des marges continentalespassives à manteau exhumé. L’extension crustale s’est produiteen régime thermique chaud comme le montre le métamorphismecrétacé des sédiments pré-rift. Les Chaînons Béarnais (PyrénéesOccidentales) représentent un témoin peu inversé de ce type demarge chaude et sont donc propices à l’étude des modalités del’amincissement crustal dans un tel système. Les analyses detempératures par spectrométrie Raman réalisées sur la couverturesédimentaire aux abords du manteau (Saraillé, Urdach, Turon dela Técouère), montrent que la totalité du système a été soumis àdes températures maximales variant de 253C à 482C. Le contacttectonique majeur entre les sédiments pré-rift décollés et lemanteau est une zone d’intense circulation de fluides avec formationde roches métasomatiques à talc+chlorite+pyrite dans lesconditions du faciès schistes verts. La géochimie isotopique (O, C,Sr) et les inclusions fluides triphasées montrent une circulation desaumures chaudes (~200C), à travers toute la couverture sédimentairedans les derniers stades de l’exhumation du manteau.Nous montrons pour la première fois que pendant l’exhumationdes péridotites : (1) les sédiments pré-rift ont subi un amincissementsyn-métamorphique avec génèse d’une foliation S0/S1 et,(2) le socle paléozoïque a été réduit à de fines lentilles tectoniquesdéformées ductilement et restées adhérentes au manteau. Ainsi, larhéologie de la croûte supérieure durant l’amincissement est contrôléeen grande partie par la présence d’une couverture sédimentairepré- et syn-rift épaisse décollée jouant le rôle d’un couverclethermique efficace. Ces nouvelles données mettent en avant le caractèrede marge passive distale chaude de la ZNP. Cela constitueun élément important pour la compréhension des mécanismes del’amincissement crustal en contexte d’exhumation du manteau etses conséquences comme héritage structural lors de l’inversion tectoniquedes bassins.
RST 2016, livre des résumés
Caen, France

insu-01387892
https://hal-insu.archives-ouvertes.fr/insu-01387892

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
We image the lithospheric and upper asthenospheric structure of western continental Yemen with 24 broadband stations to evaluate the role of the Afar plume on the evolution of the continental margin and its extent eastwards along the Gulf of Aden. We use teleseismic tomography to compute relative P-wave velocity variations in southwestern Yemen down to 300 km depth. Published receiver function analysis suggest a dramatic and localized thinning of the crust in the vicinity of the Red Sea and the Gulf of Aden, consistent with the velocity structure that we retrieve in our model. The mantle part of the model is dominated by the presence of a low velocity anomaly in which we infer partial melting just below thick Oligocene flood basalts and recent off-axis volcanic events (from 15 Ma to present). This low velocity anomaly could correspond to an abnormally hot mantle and could be responsible for dynamic topography and recent magmatism in western Yemen. Our new P-wave velocity model beneath western Yemen suggests the young rift flank volcanoes beneath margins and on the flanks of the Red Sea rift are caused by focused small-scale diapiric upwelling from a broad region of hot mantle beneath the area. Our work shows that relatively hot mantle, along with partial melting of the mantle, can persist beneath rifted margins after breakup has occurred.
ISSN: 1525-2027

hal-01015496
https://hal.archives-ouvertes.fr/hal-01015496
https://hal.archives-ouvertes.fr/hal-01015496/document
https://hal.archives-ouvertes.fr/hal-01015496/file/Korostelev_etal_GGG_2014.pdf
DOI : 10.1002/2014GC005316

Éditeur(s) : HAL CCSD American Chemical Society
Résumé : International audience
Childhood absence epilepsy is a prototypic form of generalized nonconvulsive epilepsy characterized by short impairments of consciousness concomitant with synchronous and bilateral spike-and-wave discharges in the electroencephalogram. For scientists in this field, the BS/Orl and BR/Orl mouse lines, derived from a genetic selection, constitute an original mouse model "in mirror" of absence epilepsy. The potential of MALDI imaging mass spectrometry (IMS) for the discovery of potential biomarkers is increasingly recognized. Interestingly, statistical analysis tools specifically adapted to IMS data sets and methods for the identification of detected proteins play an essential role. In this study, a new cross-classification comparative design using a combined discrete wavelet transformation-support vector machine classification was developed to discriminate spectra of brain sections of BS/Orl and BR/Orl mice. Nineteen m/z ratios were thus highlighted as potential markers with very high recognition rates (87-99%). Seven of these potential markers were identified using a top-down approach, in particular a fragment of Synapsin-I. This protein is yet suspected to be involved in epilepsy. Immunohistochemistry and Western Blot experiments confirmed the differential expression of Synapsin-I observed by IMS, thus tending to validate our approach. Functional assays are being performed to confirm the involvement of Synapsin-I in the mechanisms underlying childhood absence epilepsy.
ISSN: 1535-3893

hal-00877728
https://hal.archives-ouvertes.fr/hal-00877728
DOI : 10.1021/pr3006974
PUBMED : 22994238

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Sea cows (manatees, dugongs) are the only living marine mammals to feed solely on aquatic plants. Unlike whales or dolphins (Cetacea), the earliest evolutionary history of sirenians is poorly documented, and limited to a few fossils including skulls and skeletons of two genera composing the stem family of Prorastomidae (Prorastomus and Pezosiren). Surprisingly, these fossils come from the Eocene of Jamaica, while stem Hyracoidea and Proboscidea - the putative sister-groups to Sirenia - are recorded in Africa as early as the Late Paleocene. So far, the historical biogeography of early Sirenia has remained obscure given this paradox between phylogeny and fossil record. Here we use X-ray microtomography to investigate a newly discovered sirenian petrosal from the Eocene of Tunisia. This fossil represents the oldest occurrence of sirenians in Africa. The morphology of this petrosal is more primitive than the Jamaican prorastomids' one, which emphasizes the basal position of this new African taxon within the Sirenia clade. This discovery testifies to the great antiquity of Sirenia in Africa, and therefore supports their African origin. While isotopic analyses previously suggested sirenians had adapted directly to the marine environment, new paleoenvironmental evidence suggests that basal-most sea cows were likely restricted to fresh waters.
ISSN: 1932-6203

hal-00807308
https://hal.archives-ouvertes.fr/hal-00807308
DOI : 10.1371/journal.pone.0054307

Éditeur(s) : HAL CCSD InTech
Résumé : Available from: http://www.intechopen.com/books/evaporation-condensation-and-heat-transfer/heat-transfer-in-buildings-application-to-solar-air-collector-and-trombe-wall-design
International audience
The aim of this paper is to briefly recall heat transfer modes and explain their integration within a software dedicated to building simulation (CODYRUN). Detailed elements of the validation of this software are presented and two applications are finally discussed. One concerns the modeling of a flat plate air collector and the second focuses on the modeling of Trombe solar walls. In each case, detailed modeling of heat transfer allows precise understanding of thermal and energetic behavior of the studied structures. Recent decades have seen a proliferation of tools for building thermal simulation. These applications cover a wide spectrum from very simplified steady state models to dynamic simulation ones, including computational fluid dynamics modules (Clarke, 2001). These tools are widely available in design offices and engineering firms. They are often used for the design of HVAC systems and still subject to detailed research, particularly with respect to the integration of new fields (specific insulation materials, lighting, pollutants transport, etc.). Available from: http://www.intechopen.com/books/evaporation-condensation-and-heat-transfer/heat-transfer-in-buildings-application-to-solar-air-collector-and-trombe-wall-design
Evaporation, condensation and heat transfer

Droits : info:eu-repo/semantics/OpenAccess
ISBN : 978-953-307-583-9
hal-00767482
https://hal.archives-ouvertes.fr/hal-00767482
https://hal.archives-ouvertes.fr/hal-00767482/document
https://hal.archives-ouvertes.fr/hal-00767482/file/InTecSubmitted.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
The Imiter silver mine is a world-class deposit located in the Easternpart of the Anti-Atlas (Morocco). The deposit is hosted by Cryogenianblack shales and Ediacaran volcanics, and unconformablyoverlain byPaleozoic sedimentary rocks. The paragenetic sequence for the ganguemineral is composedby amacroscopically white quartz (Qz1) associatedwith the deposition of galena and scarce silver mineralsas matrixof hydraulic breccias, followed by a grey quartz (Qz2) associated withthe main silver deposition event and a first generation of scarcedolomite(Dol1). A third episode is characterized by massive pink dolomite precipitation(Dol2) with minor quartz (Qz3) and base metals. Finally, asurficial event affects the mineralisation and is responsible for a secondaryore enrichment.Microthermometry study coupled with Raman analyses reveals thatfluid inclusions are CaCl2-dominated. The general trend is a decreaseof temperature from Qz1 (250°C) to Dol1 (80°C) then Dol 2 (probablybelow 70°C) depositions. Fluid salinity increases from Qz1 (6.3 to 19.0wt % NaCleq) to Dol1 (27.2 % wt NaCleq), and decreases with the precipitationof Dol2 associated with quartz 3 (15 %wt NaCleq). The 18Oisotopic composition of fluids in equilibrium with quartz and dolomitesuggestsamagmatic,metamorphic and/or basinal origin for the fluid atthe origin of Qz1, and that meteoric / surficial basinal brinesmay be atthe origin of Dol2.The proposed model to explain the ore forming processes in Imiter is amixing of Ca-brines, probably providing chloride complexes, with a hotNaCl fluid of lower salinity, leading to the precipitation of silver.Theresults favour the important role of calcic brines, whose origin remainsmatter to debate in such a giant depositand for whom age of emplacementis strongly discussed.
24 ème Réunion des sciences de la Terre 2014
Pau, France

insu-01080858
https://hal-insu.archives-ouvertes.fr/insu-01080858