Éditeur(s) : HAL CCSD SAGE Publications
Résumé : International audience
This article examines the social uses of the body by the French of Tamil origin in the sports centres of Pondicherry (southern India). It reviews the ways in which the body participates in the development and expression of gender arrangements in a postcolonial context faced with globalization. An analysis of semi-structured interviews shows the extent to which the structure of gender relationships, although occurring in a specific community, is both affected by the logic of identity related to cultural affiliations and linked by more global imperatives to the symbolic relationships between the local area and the former motherland, Metropolitan France. Finally, it appears that far from stigmatizing evident gender positions, the organization of roles between the sexes follows a sociocultural rationale that leads couples to adopt strategies which accentuate the structure of gender. On returning to the country of origin, the play of gender opposition and complementarity thus enables the symbolic gender advantages achieved through emigration to be retained while at the same time avoiding the risk of social exclusion.
ISSN: 0011-3921

hal-01681884
https://hal.archives-ouvertes.fr/hal-01681884
DOI : 10.1177/0011392111400784

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND AND AIM: The impact of basal core promoter (BCP) and precore (PC) mutants of the hepatitis B virus (HBV) on liver disease severity remains controversial. The aim of the present study was to screen BCP and PC mutations in 252 HBV surface antigen (HBsAg) positive carriers in France and to assess relationships between these mutations and severe fibrosis. METHODS: Direct sequencing of the precore/core gene was used to detect A1762T/G1764A and G1757A mutations in the BCP and G1896A and G1899A mutations in the PC region. RESULTS: The prevalences of A1762T/G1764A, G1757A, G1896A, and G1899A mutations were 34.1%, 38.7%, 54.9%, and 29.3% (P < 0.001), respectively. The independent predictors of severe fibrosis (>/=F3 Metavir) were older age (P < 0.001), male gender (P = 0.012), elevated alanine aminotransferase (P < 0.001), and the double A1762T/G1764A mutant with no other mutations (P = 0.011). Interestingly, the association of the G1899A mutation with the double A1762T/G1764A mutant significantly counteracted the deleterious effect of the sole double A1762T/G1764A mutant (odds ratio [OR] = 0.28 vs. OR = 3.55, respectively, P = 0.028). CONCLUSIONS: Patients with the A1762T/G1764A mutation have a higher risk of severe fibrosis. The G1899A mutation is a protective factor against severe fibrosis that counteracted the deleterious effect of the A1762T/G1764A mutation. Finally, host phenotypic and HBV genotypic markers independently predict fibrosis severity.
Journal of gastroenterology and hepatology

hal-01477209
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477209
DOI : 10.1111/jgh.13338
PUBMED : 26992056

Éditeur(s) : HAL CCSD Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists
Résumé : International audience
Hepatic periportal fibrosis, which affects 5–10% of subjects infected by Schistosoma mansoni, is caused by the T cell-dependent granuloma that develop around schistosome eggs. Experimental models of infection have shown that granuloma and fibrosis are tightly regulated by cytokines. However, it is unknown why advanced periportal fibrosis occurs only in certain subjects. The goal of the present study was to evaluate the cytokine response of S. mansoni-infected subjects with advanced liver disease in an attempt to relate susceptibility to periportal fibrosis with an abnormal production of cytokines that regulate granuloma and fibrosis. Fibrosis was evaluated by ultrasound on 795 inhabitants of a Sudanese village in which S. mansoni is endemic: advanced periportal fibrosis was observed in 12% of the population; 35% of the affected subjects exhibited signs of portal hypertension. Age (odds ratio (OR), 11.5), gender (OR, 4.2), and infection levels (OR, 2.2) were significantly (p < 0.01) associated with hepatic fibrosis. Cytokines produced by egg-stimulated blood mononuclear cells from 99 subjects were measured (75 with no or mild fibrosis; 24 subjects with advanced fibrosis). Multivariate analysis of cytokine levels showed that high IFN-γ levels were associated with a marked reduction of the risk of fibrosis (p = ‫OR, 0.1); in contrast, high TNF-α levels were associated with an increased risk (p = 0.05; OR, 4.6) of periportal fibrosis. Moreover, infection levels were negatively associated with IFN-γ production. These results with observations in experimental models strongly suggest that IFN-γ plays a key role in the protection of S. mansoni-infected patients against periportal fibrosis, whereas TNF-α may aggravate the disease.
ISSN: 0022-1767

Droits : http://creativecommons.org/licenses/by-nc-nd/
hal-01211587
https://hal.archives-ouvertes.fr/hal-01211587
https://hal.archives-ouvertes.fr/hal-01211587/document
https://hal.archives-ouvertes.fr/hal-01211587/file/929.full.pdf
DOI : 10.4049/jimmunol.169.2.929

Résumé : L'écart de la représentation politique des femmes entre la Guadeloupe et la Martinique a été à l'origine de notre interrogation sur la socialisation politique des femmes aux Antilles françaises. En interrogeant des élus guadeloupéens et martiniquais (hommes et femmes) nous avons tenté de comprendre en quoi la socialisation politique pouvait expliquer le niveau d'engagement des femmes en politique. Le·genre étant le concept su lequel se fonde la société pour justifier la séparation et la hiérarchisation des individus masculins et féminins c'est par le biais du processus de socialisation sexué que les individus apprennent leurs rôles genrés. Si cette séparation des hommes et des femmes dans des sphères distinctes (publique et privée) tend à freiner le femmes dans leur engagement politique, les élues antillaises n'auraient pas été majoritairement touchées pas une socialisation politique sexuée. Au contraire, la matrifocalité présente aux Antilles françaises aurait permi un certain nombre de femmes d'être socialisée similairement aux hommes. Mais la société empreinte de valeurs genrées aurait tout de même freiné les femmes dans l'entame d'une carrière politique. Si la famille transmet des valeurs politiques de base, que les partis politiques n'ont qu'un rôle relatif d'agent socialisateur le monde associatif semble être un agent de socialisation déterminant en termes d'engagement politique, un révélateur et un propulseur d'hommes et de femmes dans le monde politique. Socialisés aux valeurs politiques, ces élus deviennent également des agents de socialisation politique pour les jeunes qui peuvent représenter la relève politique.
Differences in the political representation of women between Guadeloupe and Martinique were the source c our questioning about the political socialisation of women in the French West Indies. Sy interviewing elected men and women in Guadeloupe and Martinique, we tried to understand how political socialization coul explain the level of involvement of women in politics. With gender being the concept from which any societ justifies the process of separation and hierarchy between male and female individuals, it is through the sexual socialization process that individuals learn their gendered raies. If this separation between men and women in both public and private spheres tends to impede women in their political commitment, elected women of the French West Indies have not been disproportionately affected by sexual political socialization. On the contrary, the matrifocality in the French West Indies would have allowed a number of women to be socialise dsimilarly to men. However, the strong gendered values of this society would have still hampered women at the beginning of their political career. While family provides basic political values, political parties have only a relative role of socializing agent. However, associations seem to be a decisive/crucial socializing agent in terms of political commitment, acting as a career booster for men and women in politics. Socialized to political values, these elected individuals become in turn factors of political socialization for young people whe represent the next political generation.

http://www.theses.fr/2012AGUY0498/document

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : L’Asie insulaire, forte exportatrice de main-d’œuvre féminine possède-t-elle un système migratoire propre ? Les cas indonésien, philippin et sri-lankais.Les migrations de travail ont une longue tradition en Asie. Instaurées par les puissances coloniales européennes par le biais des contrats de travail, après l’abolition de l’esclavage, elles ont ainsi favorisé l’expansion de deux solides diasporas, l’une chinoise, l’autre indienne.Ce vaste continent qui abrite désormais 60 % de la population mondiale et les deux tiers de la force de travail mondiale demeure, pour longtemps encore, une zone de très forte mobilité.Trois pays, dont deux archipels et une île, les Philippines, l’Indonésie et le Sri Lanka, sont devenus, en l’espace d’une à trois décennies, les principaux exportateurs de main-d’œuvre à l’échelle mondiale. Ces politiques migratoires visent d’une part à réduire la pauvreté et le chômage et d’autre part à accroître les indispensables rentrées de devises par le biais des transferts financiers des migrants. La féminisation des flux migratoires est particulièrement marquée en Asie insulaire où la proportion de femmes avoisine les 70 % du total des migrants.
The labour migration have a long tradition in Asia. Migration, which were introduced by European colonial powers (through employment contracts, after the abolition of slavery), have encouraged the expansion of two solid diasporas, 'One China, one Indian. This vast continent, home now 60% of the world's population and two thirds of the global labor force, remains for a long time, a zone of very high mobility. Three countries, including two archipelagos and one island, the Philippines, Indonesia and Sri Lanka are now in the space of one to three decades, the main exporters of labour globally. The objective of these policies migration is a part of reducing poverty and unemployment, and secondly to increase the necessary cash currency, with financial transfers of migrants. The feminization of migration is particularly marked in Asia island where the proportion of women is around 70% of total migrants
Indonésie
Philippines
Sri Lanka

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.982
http://journals.openedition.org/etudescaribeennes/982

Éditeur(s) : HAL CCSD Impact journals
Résumé : International audience
Targeted therapies have substantially changed the management of non-small cell lung cancer (NSCLC) patients with driver oncogenes. Given the high frequency, EGFR and ALK aberrations were the first to be detected and paved the way for tyrosine kinase inhibitor (TKI) treatments. Other kinases such as ROS1 and more recently RET have emerged as promising targets, and ROS1 and RET TKIs are already available for precision medicine. We screened a large cohort of 713 Caucasian non-squamous NSCLC patients lacking EGFR/KRAS/BRAF/HER2/PI3KCA/ALK aberrations for ROS1 and RET rearrangements using fluorescence in situ hybridization to determine the frequency and clinicopathological characteristics of ROS1- and RET-positive patients. Frequencies of ROS1 and RET rearrangements were 2.1% and 2.52%, respectively. Contrary to common belief, both ROS1 and RET rearrangements were detected in patients with a history of smoking, and the RET-positive patients were not younger than the negative patients. Moreover, RET but not ROS1 rearrangement was associated with the female gender. Nearly half of the ROS1-rearranged patients were successfully treated with ROS1 TKIs. In contrast, only 5/18 RET-positive patients received off-label RET TKIs. Two patients had stable disease, and three experienced disease progression. In addition to the 18 RET-positive cases, 10 showed isolated 5' signals. The clinical relevance is unknown but if the frequency is confirmed by other groups, the question whether these patients are eligible to TKIs will arise. More potent RET TKIs are under development and may improve the response rate in RET-positive patients. Therefore, we recommend the routine implementation of RET testing in non-squamous NSCLC patients, including those with a history of smoking.
ISSN: 1949-2553

hal-01578586
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578586
DOI : 10.18632/oncotarget.18408
PUBMED : 28881815

Éditeur(s) : HAL CCSD Taylor & Francis
Résumé : International audience
To analyze the characteristics and outcome of infective endocarditis (IE) according to the time interval between IE first symptoms and diagnosis.
Among the IE cases of a French population-based epidemiological survey, patients having early-diagnosed IE (diagnosis of IE within 1 month of first symptoms) were compared with those having late-diagnosed IE (diagnosis of IE more than 1 month after first symptoms).
Among the 486 definite-IE, 124 (25%) had late-diagnosed IE whereas others had early-diagnosed IE. Early-diagnosed IE were independently associated with female gender (OR = 1.8; 95% CI [1.0-3.0]), prosthetic valve (OR= 2.6; 95% CI [1.4-5.0]) and staphylococci as causative pathogen (OR = 3.7; 95% CI [2.2-6.2]). Cardiac surgery theoretical indication rates were not different between early and late-diagnosed IE (56.3% vs 58.9%), whereas valve surgery performance was lower in early-diagnosed IE (41% vs 53%; p = .03). In-hospital mortality rates were higher in early-diagnosed IE than in late-diagnosed IE (25.1% vs 16.1%; p < .001).
The time interval between IE first symptoms and diagnosis is closely related to the IE clinical presentation, patient characteristics and causative microorganism. Better prognosis reported in late-diagnosed IE may be related to a higher rate of valvular surgery. KEY MESSAGES Infective endocarditis, which time interval between first symptoms and diagnosis was less than one month, were mainly due to Staphylococcus aureus in France. Staphylococcus aureus infective endocarditis were associated with septic shock, transient ischemic attack or stroke and higher mortality rates than infective endocarditis due to other bacteria or infective endocarditis, which time interval between first symptoms and diagnosis was more than one month. Infective endocarditis, which time interval between first symptoms and diagnosis was more than one month, were accounting for one quarter of all infective endocarditis in our study and were associated with vertebral osteomyelitis and a higher rate of cardiac surgery performed for hemodynamic indication than other infective endocarditis.
ISSN: 0785-3890

hal-01509563
https://hal.archives-ouvertes.fr/hal-01509563
PUBMED : 27607562

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
OBJECTIVES: To compare the quality of life (QoL) in three groups of workers suffering or not from shoulder pain (SP) lasting more than one month during the preceding 12 months. METHOD: Between 2002-2005, 3710 workers were randomly included in a French surveillance system of work-related musculoskeletal disorders. In 2007, 2332 responded to a follow-up questionnaire, 2049 were still active. Workers completed the Nordic Questionnaire to assess SP and the SF-36 for QoL. Three groups were defined according to health status at follow-up: Group 1: workers without SP (men: 87.9%; women: 79.2%) Group 2: workers with SP without neck, elbow and hand/wrist pain lasting more than one month during the preceding 12 months (men: 4.2%; women: 6.0%) Group 3: workers with SP and neck, elbow or hand/wrist pain lasting more than one month during the preceding 12 months (men 7.9%; women 14.8%) The mean scores of SF-36 were compared with Kruskall-Wallis test and post-hoc comparisons were performed. Analyses were stratified by gender. RESULTS: Workers in group 2 had lower scores of physical health compared to workers in group 1, whatever the gender. Workers in group 3 had lower scores of physical and mental health compared to workers in group 1. Two dimensions of mental health in men and the four dimensions of physical health and one dimension of mental health in women had lower scores in group 3 compared to group 2. CONCLUSIONS: Workers with SP and upper-limb pain have poorer QoL compared to workers without SP and workers with SP without upper-limb pain.
ISSN: 1351-0711

hal-01063898
https://hal.archives-ouvertes.fr/hal-01063898
DOI : 10.1136/oemed-2014-102362.258

Éditeur(s) : Caribbean IRN Caribbean IRN
Résumé : The entire short course on sexuality theory and research methodologies are available under an ‘Attribution, Non-Commercial, Share Alike’ licence from Creative Commons. This licence allows for work to be used as is, amended or built upon, on provision that: • Any use or amendments are undertaken for a non-commercial purpose • Credit is given to: o Module creator o Short course developers: the Caribbean Region of the International Resource Network (IRN) and the Institute for Gender & Development Studies at the University of the West Indies, St. Augustine (Trinidad). o The Ford Foundation (as short course funder). In addition, any new creations based on original modules or the original short course must be licensed under identical terms. This ensures that any derivatives of the module or the short course will also be non-commercial. Each module has the author and attribution information.
The materials for each module are the Facilitator Notes, the Outline with the suggested readings and a presentation file.

Droits : All rights reserved by the source institution.
CIRN
http://ufdc.ufl.edu/AA00027092/00001

Éditeur(s) : HAL CCSD BioScientifica
Résumé : International audience
Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported that prenatal exposure to APAP results in developmental alterations in both the reproductive tract and the brain. Genitals and nervous system of male mammals are actively masculinised during foetal development and early postnatal life by the combined actions of prostaglandins and androgens, resulting in the male-typical reproductive behaviour seen in adulthood. Both androgens and prostaglandins are known to be inhibited by APAP. Through intrauterine exposure experiments in C57BL/6 mice, we found that exposure to APAP decreased neuronal number in the sexually dimorphic nucleus (SDN) of the preoptic area (POA) in the anterior hypothalamus of male adult offspring. Likewise, exposure to the environmental pollutant and precursor of APAP, aniline, resulted in a similar reduction. Decrease in neuronal number in the SDN-POA is associated with reductions in male sexual behaviour. Consistent with the changes, male mice exposed in uteri to APAP exhibited changes in urinary marking behaviour as adults and had a less aggressive territorial display towards intruders of the same gender. Additionally, exposed males had reduced intromissions and ejaculations during mating with females in oestrus. Together, these data suggest that prenatal exposure to APAP may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming. These findings add to the growing body of evidence suggesting the need to limit the widespread exposure and use of APAP by pregnant women.
ISSN: 1470-1626

hal-01560285
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01560285
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01560285/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01560285/file/Prenatal%20exposures%20to%20paracetamol-accepted.pdf
DOI : 10.1530/REP-17-0165

Éditeur(s) : HAL CCSD Wiley
Résumé :  
Pollination ecology and reproductive success of Jack-in-the-pulpit (Arisaema triphyllum) were studied in two natural populations in Québec, Canada. Individual A. triphyllum plants can be of three types: male, female or bisexual. In both populations studied, the presence of bisexual inflorescences was not negligible (13%), where 'female' and 'male' bisexual plants were categorised according to the relative number of stamens and ovaries. 'Male bisexual' plants produce only pollen and 'female bisexual' plants produce only fruit. Hence, A. triphyllum is a true dioecious plant, as each plant only reproduces through either the male or the female function. 'Female bisexual' plants were equivalent to female plants in terms of visitation rate by insects, fructification rate and production of berries and seeds. Neither agamospermy in female plants nor self-pollination in 'female bisexual' plants was found, thus A. triphyllum relies on insects for cross-pollination. Despite the long flowering cycle, a low visitation rate was documented: only 20-40% of inflorescences were visited, according to gender, by a mean of 1.5 insects. In this study, Mycetophilidae represented the most generically diversified and abundant family, as well as the most efficient insect pollinator, especially the genera Docosia and Mycetophila.
ISSN: 1435-8603

hal-01032127
https://hal.archives-ouvertes.fr/hal-01032127
DOI : 10.1111/j.1438-8677.2009.00192.x

Éditeur(s) : HAL CCSD
Résumé : International audience
Exile and colonialism play an essential part in Jamaica Kincaid's novels. This antagonism is best expressed in Kincaid's early fiction through conflictual mother-daughter relationships. My paper aims to show that such aspects are connected facets of the identity nexus which informs the body politics of contemporary female Caribbean writers.
L'exil et le colonialisme jouent un rôle essentiel dans les romans de Jamaica Kincaid. Cet antagonisme trouve sa meilleure expression dans les premiers écrits fictionnels de Kincaid à travers des relations conflictuelle entre mère et fille. La présente étude vise à montrer que de tels aspects représentent des facettes interdépendantes du problème identitaire qui marque de son empreinte la questionnement sur le corps chez les écrivains féminins contemporains de la Caraïbe.
"Etat de l'art", Congrès de l'Association Française d'Etudes Américaines
Toulouse, France

Droits : http://hal.archives-ouvertes.fr/licences/copyright/
hal-01420756
https://hal.archives-ouvertes.fr/hal-01420756
https://hal.archives-ouvertes.fr/hal-01420756/document
https://hal.archives-ouvertes.fr/hal-01420756/file/Exil%20et%20colonialisme%20dans%20l%27oeuvre%20de%20Jamaica%20Kincaid.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Congrès SAES 2014 "Crossings"
Caen, France

hal-01664315
https://hal.archives-ouvertes.fr/hal-01664315
https://hal.archives-ouvertes.fr/hal-01664315/document
https://hal.archives-ouvertes.fr/hal-01664315/file/Travers%C3%A9e%20mystique%20et%20recherche%20du%20p%C3%A8re%20dans%20Crossing%20the%20River%20de%20Caryl%20Phillips.pdf

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : L’expansion de la microfinance en Haïti ne semble pas correspondre au développement réel des entreprises financées. Dans cet article, nous analysons dans quelle mesure les conditions de microfinancement déterminent la performance financière des microentreprises emprunteuses. À partir d’un échantillon de soixante-deux microentrepreneurs, nous avons estimé un modèle économétrique qui met en relation le chiffre d’affaires et 6 variables explicatives : taux d’intérêt, montant crédit, délai de remboursement, niveau d’éducation, localisation de l’entreprise, genre-associé. Selon nos résultats, les variables explicatives des résultats financiers des microentrepreneurs sont le délai de remboursement, le genre féminin et la localisation. Il est donc confirmé qu’un délai de remboursement long améliore les résultats financiers des microentreprises bénéficiaires de la microfinance. Par contre, un taux d’intérêt faible ne garantit pas nécessairement de meilleurs résultats financiers puisque le taux d’intérêt n’est pas corrélé significativement au chiffre d’affaires des entreprises.
The expansion of microfinance in Haiti does not seem to correspond to the actual development of microentreprises borrowing from microfinance organizations. In this article, we analyze the extent to which microfinance methodology determine the financial performance of borrowers. Based on a sample of 62 microentrepreneurs, we estimated an econometric model linking turnover and 6 explanatory variables: interest rate, credit amount, repayment period, education level, location, partner’s gender. According to our results, the variables explaining the microentrepreneurs' financial results are: the repayment period, the female gender of partner, and the location. It is therefore confirmed that a long repayment period improves the financial results of microenterprises benefiting from microfinance. On the other hand, a low interest rate does not necessarily guarantee better financial results since the interest rate is not significantly correlated with the turnover of the microentreprises.
Haïti

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.10381
http://journals.openedition.org/etudescaribeennes/10381

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
OBJECTIVES: To compare virological effectiveness in patients who continued on a virologically successful first-line boosted protease inhibitor (PI)-containing combination antiretroviral therapy (cART) regimen or who switched to a PI-free cART including efavirenz, nevirapine or abacavir. METHODS: From the French Hospital Database on HIV, we selected 439 patients with undetectable viral load (VL) on a first-line boosted PI-containing cART regimen who switched to a PI-free combination including efavirenz, nevirapine or abacavir. Each of these patients was matched with three patients who continued to take their first-line cART regimen, on the basis of gender, age, CD4 cell count, VL, date of cART initiation and the duration of VL undetectability. Time to virological failure (VF) was analysed with Kaplan-Meier curves and Cox models. RESULTS: The 12 month probabilities of VF were 3.7% and 5.7% in non-switch and switch patients, respectively, and 3.9%, 7.2% and 9.0% in patients switching to efavirenz-, nevirapine- and abacavir-containing cART, respectively. After adjustment, only patients switching to abacavir-containing cART had a higher risk of VF than non-switch patients (adjusted hazard ratio, 1.99; 95% confidence interval, 1.05-3.79). CONCLUSIONS: Switching from a virologically successful first-line boosted PI-containing cART regimen to a non-nucleoside reverse transcriptase inhibitor-containing cART regimen containing either efavirenz or nevirapine is virologically safe, while switching to abacavir-containing cART should be avoided.
ISSN: 0305-7453

hal-00875284
https://hal.archives-ouvertes.fr/hal-00875284
DOI : 10.1093/jac/dkr208
PUBMED : 21636583

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Overweight in Guadeloupe is a public health matter affecting children and adults. In the present study we evaluated the metabolic profile, including serum ghrelin, leptin and adiponectin levels, in normal weight, overweight and obese school children and we analyzed the potential changes in anthropometric and metabolic risk factors after a 1-year lifestyle intervention program. Methods: Parameters were assessed at baseline and at 1 year. Three groups (G) were defined according the International Obesity Task Force reference values, G1: normal weight / G2: overweight / G3: obese. The lifestyle intervention included dietary counseling, regular physical activity and family support. Results: A total of 120 children (G1: n = 44, G2: n = 39, G3: n = 37), aged 11– 15 years and 59 % girls were enrolled. Obese children showed significant lower HDL-C, adiponectin and ghrelin concentrations, higher triglycerides, fasting blood glucose, insulin and leptin levels and also higher frequencies of abdominal obesity (G1: 2.3 %, G2: 28.2 %, G3: 73 %) and insulin resistance (GI: 39 %, G2: 72 %, G3: 89 %) than the other groups. In the overall sample, the linear regressions exploring the associations of ghrelin, adiponectin and leptin with age, gender, BMI z-score, HOMA-IR and tanner stage as independent variables showed strong associations of leptin levels with weight status and insulin resistance at baseline. The models accounted for 58 % of variability in leptin levels compared with 26 and 15 % for adiponectin and ghrelin levels respectively. In 83 children who completed the program, significant decreases in BMI z-score in overweight and obese children were noted. Leptin levels decreased significantly only in the obese group whereas adiponectin concentrations increased significantly in the three groups, In obese children, a significant correlation was found between changes in BMI Z-score, and changes in leptin levels (r = 0.39; P = 0.049) but not with changes in adiponectin levels. Conclusions: Abdominal obesity and insulin resistance were highly prevalent in obese children highlighting their risk of metabolic complications in adulthood. A 1-year long lifestyle intervention was associated with improvement in BMI z-score and metabolic parameters.
ISSN: 1743-7075

Droits : http://creativecommons.org/licenses/by/
hal-01231394
http://hal.upmc.fr/hal-01231394
http://hal.upmc.fr/hal-01231394/document
http://hal.upmc.fr/hal-01231394/file/art_10.1186_s12986-015-0039-9.pdf
DOI : 10.1186/s12986-015-0039-9

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
OBJECTIVES:Blood rheology plays a key role in the pathophysiology of sickle cell anaemia (SS) and sickle cell haemoglobin C disease (SC), but its evolution over the lifespan is unknown.MATERIALS AND METHODS:Blood viscosity, red blood cell (RBC) deformability and aggregation, foetal haemoglobin (HbF) and haematocrit were measured in 114 healthy individuals (AA), 267 SS (161 children + 106 adults) and 138 SC (74 children + 64 adults) patients.RESULTS:Our results showed that 1) RBC deformability is at its maximal value during the early years of life in SS and SC populations, mainly because HbF level is also at its peak, 2) during childhood and adulthood, hydroxycarbamide treatment, HbF level and gender modulated RBC deformability in SS patients, independently of age, 3) blood viscosity is higher in older SS and SC patients compared to younger ones and 4) haematocrit decreases as SS patients age.CONCLUSION:The hemorheological changes detected in older patients could play a role in the progressive development of several chronic disorders in sickle cell disease, whose prevalence increases with age. Retarding these age-related haemorheological impairments, by using suitable drugs, may minimize the risks of vaso-occlusive events and chronic disorders.
ISSN: 1932-6203

Droits : http://creativecommons.org/licenses/by/
hal-01669747
https://hal.univ-antilles.fr/hal-01669747
DOI : 10.1371/journal.pone.0158182
PUBMED : 27355589
PUBMEDCENTRAL : PMC4927160

Éditeur(s) : HAL CCSD
https://hal.archives-ouvertes.fr/hal-01664245

Droits : http://creativecommons.org/licenses/by-nc-nd/
hal-01664245
https://hal.archives-ouvertes.fr/hal-01664245
https://hal.archives-ouvertes.fr/hal-01664245/document
https://hal.archives-ouvertes.fr/hal-01664245/file/L%27AUTRE%20SCENE_L%27ESPACE%20DU%20REVE%20DANS%20DREAM%20ON%20MONKEY%20MOUNTAIN%20DE%20DEREK%20WALCOTT.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Objective: In order to determine how risk factors of death among HIV-infected patients in French Guiana interact with one another and to define high risk population segments, an alternative statistical method to Cox proportional hazards models was used. Patients and methods: Data from HIV+ patients followed in the three main hospitals of French Guiana were used. Data were extracted from the prospective French Hospital Database for HIV (FHDH). To examine the nature of the relationships between time of death since the first consultation and a set of predictor variables (age at enrolment, gender, nationality, CD4 count at enrolment, presence or absence of HAART at enrolment, a declared addiction, and mode of acquisition of the virus) a survival tree analysis was used. Survival rates at 5 years and 10 years and their 95% confidence interval were also calculated. Results: This analysis permitted to reveal a new specific subgroup of HIV+ patients particularly at risk in French Guiana not already mentioned in the literature: the HIV+ female patients with a declared addiction. Conclusions: Prevention and care in this vulnerable segment of the HIV+ population identified by this methodology should be reinforced.
J AIDS Clinic Res

Droits : info:eu-repo/semantics/OpenAccess
inserm-00914956
http://www.hal.inserm.fr/inserm-00914956
http://www.hal.inserm.fr/inserm-00914956/document
http://www.hal.inserm.fr/inserm-00914956/file/2012_Hanf_-_Hierarchysur Determinants_Underlying_Death_among_HIV-Infected_patients_in_French_Guiana.pdf
DOI : 10.4172/2155-6113.1000172

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Background. An association with cancer is described in 17–32% of cases of dermatomyositis (DM) and in 5–16% of cases of anti-synthetase syndrome (ASS). The literature contains very few studies involving Afro-Caribbean patients with DM or ASS. The aim of our retrospective study was to determine the prevalence of cancer in a series of patients with DM or ASS at the University Hospital of Pointe-à-Pitre between 1st January 2000 and 31st December 2012. The secondary objective was to review the clinical and laboratory features as well as the course of DM/ASS in these patients.Patients and methods. The inclusion criteria were as follows: Afro-Caribbean origin; age >15 years; patient living in Guadeloupe; screening for malignancy.Results. Twenty-two patients were included (15 DM, 7 ASS). Only one case of cancer was diagnosed in the entire study population at a mean follow-up of 6±4 years (prevalence: 6.7%, CI95% [1.7–31.9]). Of the 15 patients presenting DM (sex ratio F/M: 4, mean age: 45±14 years), 6 (40%) had associated connective tissue disease.Conclusion. Our study suggests a weak association between DM and cancer in Afro-Caribbean patients. These results may be explained by the features of the disease seen in these patients (female gender, young age at onset, associated connective tissue disease) and the low prevalence in the Caribbean region of cancers typically associated with DM.
Introduction. Dix-sept à 32 % des cas de dermatomyosite (DM) et 5 à 16 % des cas de syndrome des anti-synthétases (SAS) sont associés à un cancer. Les séries de patients afro-caribéens atteints de DM ou de SAS sont exceptionnellement rapportées dans la littérature. Le but de notre étude rétrospective était d’estimer la prévalence des cancers dans une série de patients guadeloupéens atteints de DM ou de SAS. L’objectif secondaire était de préciser les caractéristiques cliniques, biologiques et évolutives de la maladie chez ces patients.Patients et méthode. Les critères d’inclusion étaient les suivants : patient afro-caribéen ; âge >15ans ; patient vivant en Guadeloupe ; réalisation d’un bilan d’extension à la recherche d’une néoplasie.Résultats. Vingt-deux patients ont été inclus (15 atteints de DM, 7 de SAS). Un seul cancer a été diagnostiqué, avec une durée moyenne de suivi de 6±4ans sur l’ensemble de la série (prévalence de 6,7 % ; IC 95 % [1,7 ; 31,9]). Parmi les 15 patients atteints de DM (sex-ratio H/F=1/4 ; âge moyen : 45±14ans), 6 (40 %) avaient une connectivite associée.Conclusion. Notre étude suggère une faible association entre DM et cancer chez les patients afro-caribéens. Ces résultats s’expliquent principalement par les caractéristiques de la maladie chez ces patients (sexe féminin, jeune âge, connectivite associée) et la faible prévalence, aux Antilles, des cancers classiquement associés aux DM.
ISSN: 0151-9638

inserm-01110999
http://www.hal.inserm.fr/inserm-01110999
http://www.hal.inserm.fr/inserm-01110999/document
http://www.hal.inserm.fr/inserm-01110999/file/2014%2C%20Tersiguel%20-%20Epid%C3%A9miologie%20de%20la%20dermatomyosite%20et%20du%20syndrome%20des%20anti-synth%C3%A9tases%20en%20population%20afro-carib%C3%A9enne.pdf
PUBMED : 25288059