Éditeur(s) : HAL CCSD University of Arizona
Résumé : International audience
Taiwan is a young and seismically active mountain belt, where a series of strong earthquakes (M>7) have occurred over the past hundred years. Identifying historical earthquakes around Taiwan is a key to better constrain the geodynamic of this active region. Sedimentological and geochemical analyses of surface sediments from one station offshore east Taiwan revealed the presence of coarse-grained layers interpreted as turbidites. The age of these layers have been determined by 210Pb, 137Cs, and 241Am chronology. Dating of the three most recent turbidites provides ages of AD 2001±3, AD 1950±5, and AD 1928±10. The results show striking temporal correspondence of turbidite layers to large (M≥6.8) earthquakes recorded in the region since the 20th century. The chronologies of sediment layers lead us to believe that turbidites resulted from the 2003 Taitung earthquake (M 6.8), the 1951 Chengkong earthquake (M 7.1), and the 1935 Lutao earthquake (M 7.0), respectively. Such a good correlation between turbidites and high-magnitude (M≥6.8) historical and instrumental seismic events suggests that turbidite paleoseismology constitutes a valuable tool for earthquake assessment in the eastern Taiwan margin. Moreover, the modern reservoir radiocarbon age and the regional marine reservoir correction (ΔR) of the Kuroshio Current off Taiwan were estimated by comparing accelerator mass spectrometry (AMS) 14C ages with ages derived from corrected 210Pb profiles and historical accounts of identifiable seismic events. Such a determination is important to calibrate the 14C ages of marine materials for accurate comparison of marine and continental geological records. Our calculated mean ΔR value of 232±54 14C yr (n=2) is higher than its modern value of 86±40 14C yr. This high value can be explained by the presence of local upwelling cells and turbulence in the Kuroshio Current, north of Green Island. These upwelling cells bring 14C-depleted water to the surface, resulting in an increase of the modern ΔR value in this portion of the Kuroshio Current.
ISSN: 0033-8222

hal-01306986
https://hal.archives-ouvertes.fr/hal-01306986
DOI : 10.1017/RDC.2015.3

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
We present a set of single-well injection withdrawal tracer tests in a paleoreef porous reservoir displaying important small-scale heterogeneity. An improved dual-packer probe was designed to perform dirac-like tracer injection and accurate downhole automatic measurements of the tracer concentration during the recovery phase. By flushing the tracer, at constant flow rate, for increasing time duration, we can probe distinctly different reservoir volumes and test the multiscale predictability of the (non-Fickian) dispersion models. First we describe the characteristics, from microscale to meter scale, of the reservoir rock. Second, the specificity of the tracer test setup and the results obtained using two different tracers and measurement methods (salinity-conductivity and fluorescent dye­optical measurement, respectively) are presented. All the tracer tests display strongly tailed breakthrough curves (BTC) consistent with diffusion in immobile regions. Conductivity results, measured over 3 orders of magnitude only, could have been easily interpreted by the conventional mobile-immobile (MIM) diffusive mass transfer model of asymptotic log-log slope of 2. However, the fluorescent dye sensor, which allows exploring much lower concentration values, shows that a change in the log-log slope occurs at larger time with an asymptotic value of 1.5, corresponding to the double-porosity model. These results suggest that the conventional, one-slope MIM transfer rate model is too simplistic to account for the real multiscale heterogeneity of the diffusion-dominant fraction of the reservoir.
ISSN: 0043-1397

insu-00373695
https://hal-insu.archives-ouvertes.fr/insu-00373695
https://hal-insu.archives-ouvertes.fr/insu-00373695/document
https://hal-insu.archives-ouvertes.fr/insu-00373695/file/Gouze_et_al-2008-Water_Resources_Research.pdf
DOI : 10.1029/2007WR006278

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
Although magmatism may occur during the earliest stages of continental rifting, its role in strain accommodation remains weakly constrained by largely 2-D studies. We analyze seismicity data from a 13 month, 39-station broadband seismic array to determine the role of magma intrusion on state-of-stress and strain localization, and their along-strike variations. Precise earthquake locations using cluster analyses and a new 3-D velocity model reveal lower crustal earthquakes beneath the central basins and along projections of steep border faults that degas CO2. Seismicity forms several disks interpreted as sills at 6-10 km below a monogenetic cone field. The sills overlie a lower crustal magma chamber that may feed eruptions at Oldoinyo Lengai volcano. After determining a new ML scaling relation, we determine a b-value of 0.87±0.03. Focal mechanisms for 65 earthquakes, and 13 from a catalogue prior to our array reveal an along-axis stress rotation of ∼60° in the magmatically active zone. New and prior mechanisms show predominantly normal slip along steep nodal planes, with extension directions ∼N90°E north and south of an active volcanic chain consistent with geodetic data, and ∼N150°E in the volcanic chain. The stress rotation facilitates strain transfer from border fault systems, the locus of early-stage deformation, to the zone of magma intrusion in the central rift. Our seismic, structural, and geochemistry results indicate that frequent lower crustal earthquakes are promoted by elevated pore pressures from volatile degassing along border faults, and hydraulic fracture around the margins of magma bodies. Results indicate that earthquakes are largely driven by stress state around inflating magma bodies.
ISSN: 1525-2027

hal-01667198
https://hal.archives-ouvertes.fr/hal-01667198
DOI : 10.1002/2017GC007027

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
The variation of elastic- wave velocities as a function of the direction of propagation through the Earth's interior is a widely documented phenomenon called seismic anisotropy. The geometry and amount of seismic anisotropy is generally estimated by measuring shearwave splitting, which consists of determining the polarization direction of the fast shear- wave component and the time delay between the fast and slow, orthogonally polarized, waves. In subduction zones, the teleseismic fast shear- wave component is oriented generally parallel to the strike of the trench(1), although a few exceptions have been reported (Cascadia(2) and restricted areas of South America(3,4)). The interpretation of shear- wave splitting above subduction zones has been controversial and none of the inferred models seems to be sufficiently complete to explain the entire range of anisotropic patterns registered worldwide(1). Here we show that the amount and the geometry of seismic anisotropies measured in the forearc regions of subduction zones strongly depend on the preferred orientation of hydrated faults in the subducting oceanic plate. The anisotropy originates from the crystallographic preferred orientation of highly anisotropic hydrous minerals (serpentine and talc) formed along steeply dipping faults and from the larger- scale vertical layering consisting of dry and hydrated crust - mantle sections whose spacing is several times smaller than teleseismic wavelengths. Fault orientations and estimated delay times are consistent with the observed shear- wave splitting patterns in most subduction zones.
ISSN: 0028-0836

hal-00412016
https://hal.archives-ouvertes.fr/hal-00412016
DOI : 10.1038/nature07376

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
This article documents several cases of widespread species, which usually mimic other widespread species throughout the Indo–Pacific, using endemic Marquesan species as a model and displaying endemic mimicry patterns. This discovery adds a new line of evidence to the uniqueness of the Marquesas Islands, which not only host a high number of endemic reef–fish species, but also endemic mimicry patterns.
ISSN: 0022-1112

hal-01338324
http://hal.upmc.fr/hal-01338324
http://hal.upmc.fr/hal-01338324/document
http://hal.upmc.fr/hal-01338324/file/2016_Delrieu%E2%80%90Trottin%20et%20al_When%20endemic.pdf
DOI : 10.1111/jfb.13050

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Geographical distribution of parasite species can provide insights into the evolution and diversity of parasiticcommunities. Biogeography of marine parasites is poorly known, especially because it requires anunderstanding of host-parasite interactions, information that is rare, especially over large spatial scales.Here, we have studied the biogeographical patterns of dactylogyrid parasites of chaetodontids, one of themost well-studied fish families, in the tropical Indo-west Pacific region. Dactylogyrid parasites were collectedfrom gills of 34 butterflyfish species (n = 560) at nine localities within an approximate area of62 million km2. Thirteen dactylogyrid species were identified, with richness ranging from 6 to 12 speciesat individual localities. Most dactylogyrid communities were dominated by Haliotrema angelopterum orHaliotrema aurigae, for which relative abundance was negatively correlated (q = !0.59). Parasite richnessand diversity were highest in French Polynesia and the Great Barrier Reef (Australia) and lowest in Palau.Three biogeographic regions were identified based on dactylogyrid dissimilarities: French Polynesia,characterised by the dominance of H. angelopterum, the western Pacific region dominated by H. aurigae,and Ningaloo Reef (Australia), dominated by Euryhaliotrema berenguelae. Structure of host assemblageswas the main factor explaining the dissimilarity (turnover and nestedness components of the Bray-Curtis dissimilarity and overall Bray-Curtis dissimilarity) of parasite communities between localities,while environment was only significant in the turnover of parasite communities and overall dissimilarity.Spatial structure of localities explained only 10% of the turnover of parasite communities. The interactionof the three factors (host assemblages, environment and spatial structure), however, explained the highestamounts of variance of the dactylogyrid communities, indicating a strong colinearity between the factors.Our findings show that spatial arrangement of chaetodontid dactylogyrids in the tropical Indo-westPacific is primarily characterised by the turnover of the main Haliotrema spp., which is mainly explainedby the structure of host assemblages.
ISSN: 0020-7519

hal-01562156
https://hal-univ-perp.archives-ouvertes.fr/hal-01562156
DOI : 10.1016/j.ijpara.2017.01.006

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0169-1368

hal-00345830
https://hal.archives-ouvertes.fr/hal-00345830

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Prostate cancer disparities have been reported in men of African descent who show the highest incidence, mortality, compared with other ethnic groups. Few studies have explored the genetic and environmental factors for prostate cancer in men of African ancestry. The glutathione-S-transferases family conjugates carcinogens before their excretion and is expressed in prostate tissue. This study addressed the role of GSTM1 and GSTT1 deletions on prostate cancer risk in populations of African descent. This multi-institutional case-control study gathered data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database, the African-Caribbean Cancer Consortium (AC3) and Men of African Descent and Carcinoma of the Prostate Consortium (MADCaP). The analysis included 10 studies (1715 cases and 2363 controls), five in African-Americans, three in African-Caribbean and two in African men. Both the GSTM1 and the GSTT1 deletions showed significant inverse associations with prostate cancer [odds ratio (OR): 0.90, 95% confidence interval (CI) 0.83-0.97 and OR 0.88, 95% CI: 0.82-0.96, respectively]. The association was restricted to Caribbean and African populations. A significant positive association was observed between GSTM1 deletion and prostate cancer in smokers in African-American studies (OR: 1.28, 95% CI: 1.01-1.56), whereas a reduced risk was observed in never-smokers (OR: 0.66, 95% CI: 0.46-0.95). The risk of prostate cancer increased across quartiles of pack-years among subjects carrying the deletion of GSTM1 but not among subjects carrying a functional GSTM1. Gene-environment interaction between smoking and GSTM1 may be involved in the etiology of prostate cancer in populations of African descent.
ISSN: 0143-3334

hal-00682901
https://hal.archives-ouvertes.fr/hal-00682901
DOI : 10.1093/carcin/bgr119
PUBMED : 21705483

Éditeur(s) : Inter-Research
Résumé : We studied the foraging rhythms of green sea turtles Chelonia mydas on the seagrass beds of N'Gouja Bay, Mayotte Island (Comoros Archipelago) with acoustic transmitters and moored listening stations. We monitored 8 tagged turtles (4 probable males, 3 probable females and 1 immature), from 70 to 109 cm curved carapace length (CCL), for durations ranging from 5 to 92 d. The turtles exhibited a regular diel pattern: they foraged mainly during the day (on average 87% of seagrass detections were between 06:00 and 18:00 h) and rested on the inner reef slope during the night. Night time feeding activities were observed on the seagrass bed when the night light was high. The presence of turtles on the seagrass bed at night was significantly correlated with a night light index (r = 0.54, p = 0.002), which included both moon light and cloudiness indices. Behaviour of the only immature individual observed was similar to adult turtles, although it rested more frequently around noon. All turtles displayed a high fidelity to 1 foraging site within the seagrass bed. Acoustic transmitters and permanent listening stations are an appropriate technique for long-term behavioural studies of turtles, with no human interaction with turtles during tracking, and represent a suitable technique to assess the possible effects of environmental changes or human activities upon green turtle behaviour.
Marine Ecology Progress Series (0171-8630) (Inter-Research), 2006 , Vol. 306 , P. 295-302

Droits : Inter-Research 2006
http://archimer.ifremer.fr/doc/2006/publication-3616.pdf
DOI:10.3354/meps306295
http://archimer.ifremer.fr/doc/00000/3616/

Éditeur(s) : Springer
Résumé : We present the global general circulation model IPSL-CM5 developed to study the long-term response of the climate system to natural and anthropogenic forcings as part of the 5th Phase of the Coupled Model Intercomparison Project (CMIP5). This model includes an interactive carbon cycle, a representation of tropospheric and stratospheric chemistry, and a comprehensive representation of aerosols. As it represents the principal dynamical, physical, and bio-geochemical processes relevant to the climate system, it may be referred to as an Earth System Model. However, the IPSL-CM5 model may be used in a multitude of configurations associated with different boundary conditions and with a range of complexities in terms of processes and interactions. This paper presents an overview of the different model components and explains how they were coupled and used to simulate historical climate changes over the past 150 years and different scenarios of future climate change. A single version of the IPSL-CM5 model (IPSL-CM5A-LR) was used to provide climate projections associated with different socio-economic scenarios, including the different Representative Concentration Pathways considered by CMIP5 and several scenarios from the Special Report on Emission Scenarios considered by CMIP3. Results suggest that the magnitude of global warming projections primarily depends on the socio-economic scenario considered, that there is potential for an aggressive mitigation policy to limit global warming to about two degrees, and that the behavior of some components of the climate system such as the Arctic sea ice and the Atlantic Meridional Overturning Circulation may change drastically by the end of the twenty-first century in the case of a no climate policy scenario. Although the magnitude of regional temperature and precipitation changes depends fairly linearly on the magnitude of the projected global warming (and thus on the scenario considered), the geographical pattern of these changes is strikingly similar for the different scenarios. The representation of atmospheric physical processes in the model is shown to strongly influence the simulated climate variability and both the magnitude and pattern of the projected climate changes.
Climate Dynamics (0930-7575) (Springer), 2013-05 , Vol. 40 , N. 9-10 , P. 2123-2165

Droits : The Author(s) 2013. This article is published with open access at Springerlink.com
http://archimer.ifremer.fr/doc/00138/24966/23079.pdf
DOI:10.1007/s00382-012-1636-1
http://archimer.ifremer.fr/doc/00138/24966/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
IODP Site U1309 was drilled at Atlantis Massif, an oceanic core complex, at 30 degrees N on the Mid-Atlantic Ridge (MAR). We present the results of a bulk rock geochemical study (major and trace elements) carried out on 228 samples representative of the different lithologies sampled at this location. Over 96% of Hole U1309D is made up of gabbroic rocks. Diabases and basalts cross-cut the upper part of the section; they have depleted MORB compositions similar to basalts sampled at MAR 30 degrees N. Relics of mantle were recovered at shallow depth. Mantle peridotites show petrographic and geochemical evidence of extensive melt-rock interactions. Gabbroic rocks comprise: olivine-rich troctolites (>70% modal olivine) and troctolites having high Mg# (82-89), high Ni (up to 2300 ppm) and depleted trace element compositions (Yb 0.06-0.8 ppm); olivine gabbros and gabbros (including gabbronorites) with Mg# of 60-86 and low trace element contents (Yb 0.125-2.5 ppm); and oxide gabbros and leucocratic dykes with low Mg# (<50), low Ni (similar to 65 ppm) and high trace element contents (Yb up to 26 ppm). Troctolites and gabbros are amongst the most primitive and depleted oceanic gabbroic rocks. The main geochemical characteristics of Site U1309 gabbroic rocks are consistent with a formation as a cumulate sequence after a common parental MORB melt, although (lack of systematic) downhole variations indicate that the gabbroic series were built by multiple magma injections. In detail, textural and geochemical variations in olivine-rich troctolites and gabbronorites suggest chemical interaction (assimilation?) between the parental melt and the intruded lithosphere. Site U1309 gabbroic rocks do not represent the complementary magmatic product of 30 degrees N volcanics, although they sample the same mantle source. The bulk trace element composition of Site U1309 gabbroic rocks is similar to primitive MORB melt compositions; this implies that there was no large scale removal of melts from this gabbro section. The occurrence of such a large magmatic sequence implies that a high magmatic activity is associated with the formation of Atlantis Massif. Our results suggest that almost all melts feeding this magmatic system stays trapped into the intruded lithosphere.
ISSN: 0012-821X

hal-00413562
https://hal.archives-ouvertes.fr/hal-00413562
DOI : 10.1016/j.epsl.2008.12.034

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Collisional mountain belts grow as a consequence of continental plate convergence and eventuallydisappear under the combined effects of gravitational collapse and erosion. Using a decade ofGPS data, we show that the western Alps are currently characterized by zero horizontal velocityboundary conditions, offering the opportunity to investigate orogen evolution at the time ofcessation of plate convergence. We find no significant horizontal motion within the belt, but GPS andlevelling measurements independently show a regional pattern of uplift reaching ~2.5 mm/yr in thenorthwestern Alps. Unless a low viscosity crustal root under the northwestern Alps locally enhancesthe vertical response to surface unloading, the summed effects of isostatic responses to erosion andglaciation explain at most 60% of the observed uplift rates. Rock-uplift rates corrected from transientglacial isostatic adjustment contributions likely exceed erosion rates in the northwestern Alps. In theabsence of active convergence, the observed surface uplift must result from deep-seated processes.
ISSN: 2045-2322

hal-01357450
https://hal.archives-ouvertes.fr/hal-01357450
https://hal.archives-ouvertes.fr/hal-01357450/document
https://hal.archives-ouvertes.fr/hal-01357450/file/noquet2016.pdf
DOI : 10.1038/srep28404

Éditeur(s) : HAL CCSD
Résumé : Atmospheric carbon dioxide records indicate that the land surface has acted as a strong global carbon sink over recent decades, with a substantial fraction of this sink probably located in the tropics, particularly in the Amazon. Nevertheless, it is unclear how the terrestrial carbon sink will evolve as climate and atmospheric composition continue to change. Here we analyse the historical evolution of the biomass dynamics of the Amazon rainforest over three decades using a distributed network of 321 plots. While this analysis confirms that Amazon forests have acted as a long-term net biomass sink, we find a long-term decreasing trend of carbon accumulation. Rates of net increase in above-ground biomass declined by one-third during the past decade compared to the 1990s. This is a consequence of growth rate increases levelling off recently, while biomass mortality persistently increased throughout, leading to a shortening of carbon residence times. Potential drivers for the mortality increase include greater climate variability, and feedbacks of faster growth on mortality, resulting in shortened tree longevity. The observed decline of the Amazon sink diverges markedly from the recent increase in terrestrial carbon uptake at the global scale, and is contrary to expectations based on models.
ISSN: 1476-4687

hal-01204223
https://hal.archives-ouvertes.fr/hal-01204223
DOI : 10.1038/nature14283
PRODINRA : 294797
PUBMED : 25788097

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
In the Wadi Haymiliyah of the Oman ophiolite (Haylayn block), discordant wehrlite bodies ranging in size from tens to hundreds of meters intrude the lower crust at different levels. We combined investigations on natural wehrlites from the Wadi Haymiliyah section with an experimental study on the phase relations in a wehrlitic system in order to constrain the petrogenesis of the crustal wehrlites of the Oman ophiolite. Secondary ion mass spectrometry analyses of clinopyroxenes from different wehrlite bodies imply that the clinopyroxenes were crystallized from tholeiitic, mid-ocean ridge (MORB)-type melts. The presence of primary magmatic amphiboles in some wehrlites suggests a formation under hydrous conditions. Significantly enhanced Sr-87/Sr-86 isotope ratios of separates from these amphiboles imply that the source of the corresponding magmatic fluids was either seawater or subduction zone-related. The experiments revealed that under wet conditions at relatively low temperatures, a MORB magma has the potential to produce wehrlite in the ocean crust by accumulation of early olivine and clinopyroxene. These show typically high Mg# which is a consequence of the oxidizing effect of the prevailing high aH(2)O. First plagioclases crystallizing after clinopyroxene under wet conditions are high in An content, in contrast to the corresponding dry system. Trace element compositions of clinopyroxenes of those wehrlites from the Moho transition zone are too depleted in HREE to be in equilibrium with present-day MORB, implying a genetic relation to the V2 lavas of the Oman ophiolite, which are interpreted to be the result of fluid-enhanced melting of previously depleted mantle. We present a model on the petrogenesis of the crustal wehrlites in an upper mantle wedge above an initial, shallow subduction zone at the beginning of the intraoceanic thrusting.
ISSN: 1525-2027

hal-00429373
https://hal.archives-ouvertes.fr/hal-00429373
DOI : 10.1029/2009GC002488

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
ISSN: 0029-8549

hal-00524665
https://hal.archives-ouvertes.fr/hal-00524665

Éditeur(s) : HAL CCSD Bureau de recherches géologiques et minières
Résumé : Du relief au bassin
ISSN: 0292-8477

hal-00795450
https://hal.archives-ouvertes.fr/hal-00795450

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
An intensive water vapour intercomparison effort, involving airborne and ground-based water vapour lidar systems, was carried out in the framework of the COPS experiment. The main objective of this paper is to provide accurate error estimates for these systems. Comparisons between the ground-based Raman lidar BASIL and the airborne CNRS DIAL (Differential Absorption Lidar) indicate a mean relative bias between the two sensors, calculated with respect to the mean value of −2.13% (−0.034 g kg−1) in the altitude region 0.5-3.5 km, while comparisons between BASIL and the airborne DLR DIAL lead to a mean relative bias of 1.87% (0.018 g kg−1) in this same altitude region. Comparisons between the ground-based UHOH DIAL and the CNRS DIAL indicate a bias of −3.2% (−0.37 × 1022 m−3) in the altitude range 1.5-4.5 km, while comparisons between the UHOH DIAL and the DLR DIAL indicate a bias of 0.83% (0.06 × 1022 m−3) in this same altitude range. Based on the available comparisons between the ground-based Raman lidar BERTHA and the CNRS DIAL, the mean relative bias is found to be −4.37% (−0.123 g kg−1) in the altitude region 0.5-4.5 km. Comparisons between the ground-based IGN Raman lidar and the CNRS DIAL indicate a bias of 3.18% (0.55 g kg−1) in the altitude range from 0.5 to 4.5 km, while comparisons between the CNRS DIAL and DLR DIAL result in a mean relative bias of 3.93% (1.1 × 1022 m−3) in the altitude interval 0.5-4.0 km. Based on the available statistics of comparisons, benefiting from the fact that the CNRS DIAL was able to be compared with all other lidar systems, and putting equal weight on the data reliability of each instrument, overall relative values for BASIL, BERTHA, IGN Raman lidar, UHOH DIAL, DLR DIAL, and CNRS DIAL, with respect to the mean value, are found to be −0.38, −2.60, 4.90, −1.43, −2.23 and 1.72%, respectively.
ISSN: 0035-9009

hal-00572576
https://hal.archives-ouvertes.fr/hal-00572576
DOI : 10.1002/qj.697

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : International audience
This paper presents a comparison of models for extreme rainfall and flood values. Based on a large set of thousands of rainfall and discharge data, the French ExtraFlo project showed that design estimate of extreme values based on the fitting of a distribution on a limited sample of maximum values is very inaccurate when only a few decades of observation are available. Some interesting alternatives are possible, using a regional approach, or historical data when available, or simulation methods, or sedimentological or geochemical signatures of flood deposits.
Cette communication présente les principaux résultats du projet ExtraFlo sur l'estimation des pluies et crues extrêmes. A partir d'un jeu de données conséquent de plusieurs milliers de stations, une procédure d'inter-comparaison a permis d'évaluer les performances d'une trentaine d'implémentations différentes issues de différentes combinaisons (modèle probabiliste, méthode d'estimation, cadre local / régional / mixte local et régional). Le projet ExtraFlo a permis de mettre en évidence le manque de robustesse des approches basées sur le traitement statistique d'une série de quelques dizaines d'années d'observation. Des alternatives intéressantes existent, basées sur l'exploitation des records de pluie et de débit à l'échelle d'une région, de la collecte de données historiques quand cela est possible, de méthodes de simulation basées sur le couplage d'un générateur d'averses avec un modèle hydrologique pour la transformation des pluies en débit, ou des traces morphologiques laissées par les crues anciennes.
ISSN: 0018-6368

hal-01128341
https://hal.archives-ouvertes.fr/hal-01128341
https://hal.archives-ouvertes.fr/hal-01128341/document
https://hal.archives-ouvertes.fr/hal-01128341/file/ly2014-pub00041933.pdf
DOI : 10.1051/lhb/2014010

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Necroptosis is a programmed cell death pathway that has been shown to be of central pathophysiological relevance in multiple disorders (hepatitis, brain and cardiac ischemia, pancreatitis, viral infection and inflammatory diseases). Necroptosis is driven by two serine threonine kinases, RIPK1 (Receptor Interacting Protein Kinase 1) and RIPK3, and a pseudo-kinase MLKL (Mixed Lineage Kinase domain-Like) associated in a multi-protein complex called necrosome. In order to find new inhibitors for use in human therapy, a chemical library containing highly diverse chemical structures was screened using a cell-based assay. The compound 6E11, a natural product derivative, was characterized as a positive hit. Interestingly, this flavanone compound: inhibits necroptosis induced by death receptors ligands TNF-α (Tumor Necrosis Factor) or TRAIL (TNF-Related Apoptosis-Inducing Ligand); is an extremely selective inhibitor, among kinases, of human RIPK1 enzymatic activity with a nM Kd; has a non-ATP competitive mode of action and a novel putative binding site; is weakly cytotoxic towards human primary blood leukocytes or retinal pigment epithelial cells at effective concentrations; protects human aortic endothelial cells (HAEC) from cold hypoxia/reoxygenation injury more effectively than necrostatin-1 (Nec-1) and Nec-1s. Altogether, these data demonstrate that 6E11 is a novel potent small molecular inhibitor of RIPK1-driven necroptosis.
ISSN: 2045-2322

hal-01616456
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456/file/s41598-017-12788-4.pdf
DOI : 10.1038/s41598-017-12788-4

Éditeur(s) : HAL CCSD Elsevier
Résumé : We studied the evolution of the microstructure of ice-Ih during static recrystallization by stepwise annealing experiments. We alternated thermal annealing and electron backscatter diffraction (EBSD) analyses on polycrystalline columnar ice pre-deformed in uniaxial compression at temperature of −7 °C to macroscopic strains of 3.0–5.2. Annealing experiments were carried out at −5 °C and −2 °C up to a maximum of 3.25 days, typically in 5–6 steps. EBSD crystal orientation maps obtained after each annealing step permit the description of microstructural changes. Decrease in average intragranular misorientation at the sample scale and modification of the misorientation across subgrain boundaries provide evidence for recovery from the earliest stages of annealing. This initial evolution is similar for all studied samples irrespective of their initial strain or annealing temperature. After an incubation period ≥1.5 h, recovery is accompanied by recrystallization (nucleation and grain boundary migration). Grain growth proceeds at the expense of domains with high intragranular misorientations, consuming first the most misorientated parts of primary grains. Grain growth kinetics fits the parabolic growth law with grain growth exponents in the range of 2.4–4.0. Deformation-induced tilt boundaries and kink bands may slow down grain boundary migration. They are stable features during early stages of static recrystallization, only erased by normal growth, which starts after >24 h of annealing.
ISSN: 0191-8141

hal-01685644
https://hal.archives-ouvertes.fr/hal-01685644
DOI : 10.1016/j.jsg.2017.05.001