Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: The TGF-β transforming growth factor is the most pleiotropic cytokine controlling a broad range of cellular responses that include proliferation, differentiation and apoptosis. The context-dependent multifunctional nature of TGF-β is associated with complex signaling pathways. Differential models describe the dynamics of the TGF-β canonical pathway, but modeling the non-canonical networks constitutes a major challenge. Here, we propose a qualitative approach to explore all TGF-β-dependent signaling pathways. RESULTS: Using a new formalism, CADBIOM, which is based on guarded transitions and includes temporal parameters, we have built the first discrete model of TGF-β signaling networks by automatically integrating the 137 human signaling maps from the Pathway Interaction Database into a single unified dynamic model. Temporal property-checking analyses of 15934 trajectories that regulate 145 TGF-β target genes reveal the association of specific pathways with distinct biological processes. We identify 31 different combinations of TGF-β with other extracellular stimuli involved in non-canonical TGF-β pathways that regulate specific gene networks. Extensive analysis of gene expression data further demonstrates that genes sharing CADBIOM trajectories tend to be co-regulated. CONCLUSIONS: As applied here to TGF-β signaling, CADBIOM allows, for the first time, a full integration of highly complex signaling pathways into dynamic models that permit to explore cell responses to complex microenvironment stimuli.
ISSN: 1752-0509

inserm-00978313
http://www.hal.inserm.fr/inserm-00978313
http://www.hal.inserm.fr/inserm-00978313/document
http://www.hal.inserm.fr/inserm-00978313/file/1752-0509-8-30.pdf
DOI : 10.1186/1752-0509-8-30

Éditeur(s) : HAL CCSD
Résumé : The Deep Basin of the Gulf of Mexico (DBGM) extends over eastern Mexico, the southeastern part of the United States, west of the Atlantic Ocean. This study, based on the interpretation and integration of seismic profiles, exploration wells and outcrop studies, focus on the deep part of the Gulf of Mexico, where bathymetry varies from 200 to 3750 m, thus comprising both the continental slope and the abyssal plain. The first part of this thesis focus on the description of the sedimentary infill of the western part of the Gulf of Mexico, in the Veracruz State, and to its geodynamic controls. The geodynamic evolution of the Deep Basin of the Gulf of Mexico (DBGM) begins during the Triassic-Jurassic with the break-up and the opening of a continental rift, in the southern part of the North American lithospheric plate. This opening induced a relative movement of the Yucatan Block towards the southeast. This intra-continental rifting episode was followed by a stage of post-rift thermal subsidence in the basins of the continental margin in the west, coeval with oceanic accretion in the DBGM. The thermal subsidence of the margin was subsequently modified by the Laramian orogeny, which impacted strongly the overall architecture of the margin as well as its litho-stratigraphic evolution, inducing the deposition of siliciclastic deposits in various morphotectonic provinces: i.e., near the tectonic front of the Sierra Madre Oriental (SMO), within the adjacent Chicontepec foreland basin, over the Tuxpan Platform (Golden Lane), across the continental slope and up to the deep abyssal plain, these two last morphotectonic provinces belonging to the DBGM. During the Early Paleogene, the effects of the thermal subsidence of the passive margin were stressed by the tectonic load of the Laramian orogen (i.e., the Sierra Madre Oriental, SMO), thus allowing the development of a foreland basin flexural. In this geodynamic framework, the main sedimentary transfers developed from the tectonic front "SMO" in the west, towards the DBGM in the east, the main source for clastic sediments being linked to the erosion of the "SMO" mountains. During the Paleocene and the Early Eocene, the architecture of the silici-clastic syn-tectonic sediments deposited in submarine fans was characterized by sliding, turbidites with A and B Bouma facies, as well as levees and channels. After the stop of the flexural subsidence, the thermal subsidence of the passive margin resumed during the Late Eocene, the Oligocene and the Neogene, allowing the development of a new sedimentary prism, prograding eastwards toward the DBGM. This sedimentary infill was again made up of levees-channels, sand bars and delta systems. During the Neogene, an extensional system with listric faults and roll-over features developed across the slope of the DBGM, due to an active detachment developing within overpressured Eocene-Oligocene clays. This gravitational gliding of Neogene series accounted also for the development of compressional features at the toe of the slope. Approximately 60% of the Miocene siliciclastic sediments have been trapped in growth strata and slope basins associated with this complex gravitational system, ranging from river-delta features towards gravity slides associated with slump facies. The second part of this thesis aims at a quantification of these various processes, including the construction of balanced cross sections, forward Thrustpack kinematic modelling coupling the development of a basal detachment, lithospheric flexure, erosion and sedimentation, as well as subsequent stratigraphic modelling with the Dionisos software, the later aiming at predicting the sand versus clay ratios in Neogene siliciclastic deposits of the DBGM and its surroundings.
Le bassin profond du Golfe du Mexique (BPMG) est localisé à l'est du Mexique, au sud-est des États-Unis et à l'ouest de l'Océan Atlantique. Cette étude de la partie profonde du Golfe du Mexique est basée sur l'intégration de données de sismique, de forages pétroliers et d'études de terrain; elle comprend toute la pente continentale et la plaine abyssale, avec une bathymétrie qui varie de 200 à 3750 m. La première partie de cette thèse est consacrée à la description du remplissage sédimentaire de la bordure occidentale du Golfe du Mexique, dans le secteur de Veracruz, en liaison avec son évolution géodynamique. L'évolution géodynamique du BPMG commence au Trias-Jurassique avec la rupture et la propagation d'un rift continental, dans le secteur sud de la plaque nord américaine. Cette ouverture et le déplacement relatif vers le sud-est du bloc crustal du Yucatan sont à l'origine du BPGM. Cette géodynamique de rift continental est suivie d'une étape post-rift accompagnée de l'océanisation du bassin. Les bassins de la marge passive ont poursuivi leur évolution sous l'effet de la subsidence thermique à l'ouest du Golfe du Mexique, tandis que de la croûte océanique se formait dans le BPGM. Cette subsidence thermique de la marge a ensuite été perturbée par l'orogénèse Laramienne, qui a remodelé l'architecture stratigraphique silico-clastique des dépôts du Tertiaire entre les éléments morphotectoniques suivants: lefront tectonique de la Sierra Madre Orientale (SMO), le bassin d'avant-pays Chicontepec, la Plateforme de Tuxpan-Faja de Oro, la pente continentale et la plaine abyssale, ces deux dernières provinces morphotectoniques appartenant au BPGM. Pendant le Paléogèneinférieur, les effets de la subsidence thermique de la marge passive ont été accentués par la charge tectonique de l'orogénèse laramienne (SMO), permettant ainsi le développement d'un bassin flexural d'avant-pays. Au cours de cette étape, les principaux transferts sédimentaires se sont effectués du front tectonique "SMO" vers le BPGM. La source principale de sédiments clastiques est liée à l'érosion de la chaîne de montagnes "SMO". Pendant le Paléocène et l'Éocène inférieur, l'architecture des premiers sédiments silico-clastiques syn-tectoniques déposés dans des éventails sous-marins sont caractérisés par des figures de glissement, des faciès turbiditiques A et B de Bouma, des chenaux-levées. Après l'arrêt de la subsidence flexurale, la subsidence thermique de la marge passive s'est poursuivie pendant l'Éocène supérieur, l'Oligocène et le Néogène, permettant le développement d'un nouveau prisme sédimentaire progradant. Les remplissages sédimentaires sont encore constitués de chenaux et de levées, avec des barres de sable associées à des systèmes deltaïques sur la plateforme. Pendant le Néogène, un système de failles listriques s'est développé sur la pente du BPGM, au-dessus d'une surface de décollement située, dans la région d'étude, dans les argiles de l'Éocène-Oligocène. Ce système de failles de croissance a piégé plus de 60% des sédiments silico-clastiques du Miocène. Ce remplissage sédimentaire évolue latéralement de faciès fluviaux deltaïques vers des faciès de pente affectés de glissements gravitaires et associés à des turbidites. La deuxième partie de cette thèse est consacrée à une approche quantitative basée sur des modélisations structurales (coupes équilibrées et modélisations cinématiques directes avec Thrustpack, couplant décollement gravitaire, flexure lithosphérique, érosion et sédimentation), puis sédimentaires (prise en compte des transferts de matériel clastique depuis la partie émergée de la chaîne jusqu'au bassin profond, à l'aide du logiciel Dionisos, afin de mieux comprendre les processus de piégeage des sédiments grossiers dans les structures de croissance et les bassins perchés de la marge.
https://tel.archives-ouvertes.fr/tel-00435120

tel-00435120
https://tel.archives-ouvertes.fr/tel-00435120
https://tel.archives-ouvertes.fr/tel-00435120/document
https://tel.archives-ouvertes.fr/tel-00435120/file/thesealzaga.pdf

Éditeur(s) : Blackwell science
Résumé : The trophic level mean and variance, and the degree of omnivory for five Celtic Sea fish predators were estimated using a database of stomach content records characterized by a high level of taxonomic resolution. The predators occupied a high position in the food web, i.e. 4.75 for Atlantic cod Gadus morhua, 444 for haddock Melanogrammus aeglefinus, 4.88 for European hake Merluccius merluccius, 5.00 for megrim Lepidorhombus whiffiagonis and 5.27 for whiting Merlangius merlangus. The level of taxonomic resolution of the prey did not greatly affect mean T-L predator values; an effect on variance was evident, low resolution masking intra-population variability in T-L. Generalized additive models (GAM) were used to explain the variability of predator T-L caused by environmental variables (international Council for the Exploration of the Sea, ICES, division and season) and predator characteristics (total length, L-T). Significant year, location season and interaction effects were found for some species and with L-T, at the scale of ICES subdivision. The species-specific variability of T-L could be due to spatio-temporal variations in prey availability and in predator selectivity following ontogenetic changes. Omnivorous fish T-L. was less affected by spatio-temporal variations. In addition, results showed that the omnivory index and T-L variability provide dissimilar information on predator feeding strategy. Combining information on T-L. variability and omnivory allowed between within individual and between-individual components contributing to trophic niche width to be separated and the type of generalization of fish predators to be identified. (c) 2008 The Authors Journal compilation (c) 2008 The Fisheries Society of the British Isles.
Journal of Fish Biology (0022-1112) (Blackwell science), 2008-09 , Vol. 73 , N. 4 , P. 763-781

Droits : 2008 Wiley Blackwell Publishing, Inc. The Fisheries Society of the British Isles
http://archimer.ifremer.fr/doc/2008/publication-4699.pdf
DOI:10.1111/j.1095-8649.2008.01938.x
http://archimer.ifremer.fr/doc/00000/4699/

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : L’image idyllique du tourisme de luxe dans certains territoires de la Caraïbe, de l’océan Indien et du Pacifique fait souvent rêver et attire depuis longtemps une clientèle fortunée. Pour autant, les dépenses effectuées sur place par cette clientèle induisent-elles véritablement des retombées positives sur la croissance et le développement économique de ces territoires, sur le niveau de vie de la population, contribue-t-il à combattre le chômage et à réduire la pauvreté ? Quels en sont les impacts au plan environnemental et humain ? En deux mots, les principes du développement durable trouvent-ils sur place un terrain d’application favorable et conforme à ce concept ? Pour y répondre, Anguilla, petite destination touristique de luxe de la Caraïbe, fréquentée majoritairement par une clientèle de séjour en provenance des États-Unis est utilisée comme étude de cas. Aussi, cette étude a pour but d’analyser les relations complexes entre le tourisme et la problématique du développement local dans ce microterritoire, en se fixant deux objectifs : en premier lieu, voir si l’hypothèse de la croissance tirée par le tourisme est une option concevable dans cette petite destination touristique. En second lieu, vérifier si l’activité touristique exerce un impact positif sur le développement économique inclusif d’Anguilla, par sa capacité ou non à stimuler les autres secteurs d’activité. À cet effet, deux modèles de régression employés dans un cadre de cointégration sont utilisés successivement. D’une part, les résultats montrent qu’un accroissement de 1 % de la recette touristique à Anguilla se traduit à long terme par une augmentation de 0,6 % de son PIB, confirmant ainsi l’hypothèse de la croissance tirée par le tourisme. De plus, les tests de causalité de Granger révèlent l’existence d’une causalité bidirectionnelle entre activité touristique et croissance économique. D’autre part, ces résultats montrent que la croissance du secteur touristique s’accompagne par une contraction de l’activité agricole à Anguilla, engendrant de ce fait une perte de ressources pour le pays, ainsi qu’un accroissement de « fuites » liées aux importations dérivées. En conséquence, le potentiel du tourisme en tant que facteur de développement inclusif devient une hypothèse irrecevable dans ce petit territoire, et ce, en raison des effets multiplicateurs et de liaison limités sur les producteurs locaux.
The romantic image of luxury tourism in Caribbean, Indian Ocean, and pacific islands make you often dream and attracts for many years a high profile customer. Would the expenses incurred by the visitors lead to a positive impacts on economic growth? What are the impacts on environment and human aspects? Briefly, does the principles of sustainable and inclusive development a concept applicable in these islands? Anguilla, a small luxury island in the Caribbean area is used as case study. The purpose of this study is to determine the role of tourism in the economy of Anguilla. More specifically, this investigation attempts to verify the presence of the tourism-led growth hypothesis (TLGH) in the case of Anguilla, also to explore the nature of the linkage between the tourism sector and the agriculture, manufacturing and other service industries in the long-run and the short-run. In so doing, two regression models are used in a cointegration framework. The long-run relation indicates that a 1% change in tourism revenues in Anguilla would lead to a 0.6% increase in real GDP in the long-run, ceteris paribus. Our findings have also empirically verified the presence of the tourism-led growth hypothesis. However, the application of the error-correction methodology, produced results which suggested that the agriculture sector has contracted as the tourism sector expanded. In conclusion, the economic growth in Anguilla is positively affected by growth in the tourism sector as the latter sector loses resources to the expanding sector.
Anguilla
Caraïbes

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.7409
http://journals.openedition.org/etudescaribeennes/7409

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We use 3-D mechanical modeling representing faults as planar surfaces with frictional properties that obey Coulomb-failure process to explore the long-term slip rates of the Altyn Tagh fault and Kunlun faults in the north Tibetan plateau. Crustal theology is simplified as an elastoplastic upper crust and a viscoelastic lower crust. Far-field GPS velocities and late Quaternary fault slip rates are used to constrain the model results. Rheological tests show that effective fault friction lower than 0.1-0.08 leads to high slip rates that fit with geologically and geodetically determined slip rates of the Kunlun fault (10-11.7 +/- 1.5 mm/yr). Meanwhile, the modeled Altyn Tagh fault reaches slip rates similar to 13.7 mm/yr to similar to 7.8 mm/yr in its central portion, between ranges of the geological slip rates. Associated with high slip rates, our model predicts that central Tibet (similar to 84 degrees E-95 degrees E) from the Altyn Tagh fault to the north of the Himalayan arc accommodates north-south shortening and east-west extension rates of similar to 10-12 mm/yr and similar to 8-10 mm/yr, respectively. We also question the widely accepted idea that interseismic strain is driven at the base of the seismogenic zone by a screw dislocation. If this assumption fails, the presented model implies that interseismic strain around large strike-slip faults could be distributed in a much broader way if the lithosphere deforms as a thin elastic plate rather than an elastic half-space with an embedded dislocation. If this distributed deformation is ignored, and the instantaneous surface deformation field modeled as that resulting from slip on a dislocation below a specified depth embedded in an elastic half-space, the estimated slip rate will inevitably be lower than the true long-term slip rate. This appears to explain why geodetic slip rates proposed for the Altyn Tagh fault (510 mm/yr) are lower than some of the geological slip rates. (C) 2008 Elsevier B.V. All rights reserved.
ISSN: 0012-821X

hal-00411926
https://hal.archives-ouvertes.fr/hal-00411926
DOI : 10.1016/j.epsl.2008.06.049

Éditeur(s) : HAL CCSD
Résumé : International audience
The study of complex biological processes requires to forgo simplified models for extensive ones. Yet, these models' size and complexity place them beyond understanding. Their analysis requires new methods for identifying general patterns. The Transforming Growth Factor TGF-β is a multifunctional cytokine that regulates mammalian cell development , differentiation, and homeostasis. Depending on the context, it can play the antagonistic roles of growth inhibitor or of tumor promoter. Its context-dependent pleiotropic nature is associated with complex sig-naling pathways. The most comprehensive model of TGF-β-dependent signaling is composed of 15,934 chains of reactions (trajectories) linking TGF-β to at least one of its 159 target genes. Identifying functional patterns in such a network requires new automated methods. This article presents a framework for identifying groups of similar trajec-tories composed of the same molecules using an exhaustive and without prior assumptions approach. First, the trajectories were clustered using the Relevant Set Correlation model, a shared nearest-neighbors clustering method. Five groups of trajectories were identified. Second, for each cluster the over-represented molecules were determined by scoring the frequency of each molecule implicated in trajectories. Third, Gene set enrichment analysis on the clusters of trajectories revealed some specific TGF-β-dependent biological processes, with different clusters associated to the antagonists roles of TGF-β. This confirms that our approach yields biologically-relevant results. We developed a web interface that facilitates graph visualization and analysis. Our clustering-based method is suitable for identifying families of functionally-similar trajectories in the TGF-β signaling network. It can be generalized to explore any large-scale biological pathways.
CMSB 2017 - 15th International Conference on Computational Methods in Systems Biology
Darmstadt, France

hal-01559249
https://hal.archives-ouvertes.fr/hal-01559249
https://hal.archives-ouvertes.fr/hal-01559249/document
https://hal.archives-ouvertes.fr/hal-01559249/file/JeanCoquet_CMSB.pdf

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
AimEcological connectivity is currently considered to be essential to enhance biodiversity conservation efforts and benefit adjacent areas. We evaluate the spatial structure of vulnerable marine benthic invertebrate populations based on connectivity to improve the placement of marine protected areas.LocationGulf of Lions, NW Mediterranean Sea.MethodsWe used a spatially explicit metapopulation model to explore how larval dispersal affects marine benthic invertebrate dynamics at local and regional scales. Minimum recruitment success (the proportion of larvae that settle in a site and survive between spawning and first reproduction, which is required to ensure species persistence) is proposed as a measure of vulnerability. Three contrasting simulations were constructed: closed versus connected populations, habitat loss versus recruitment failure disturbances and varying patterns of oceanographic connectivity. The rescue factor (the ratio of minimum recruitment success in connected and closed populations) quantified the decrease in vulnerability because of oceanographic connectivity.ResultsIn the Gulf of Lions, connectivity reduced population vulnerability by a rescue factor of 5.3. The minimum recruitment success for regional persistence decreased from 3% to 0.2% when species' life expectancies increased from 2 to 50 years. Connectivity enabled the spread of individuals over the entire region, but there were higher densities in sink sites, where low retention rates do not allow for local persistence (western tip of the gulf). Source sites, defined as those sites bringing metapopulation resistance to recruitment failure and stresses from habitat loss, were located in the centre of the gulf.Main conclusionsConnectivity drives the spatial structure of population density distribution and population vulnerability in the absence of any other structuring factor. In the Gulf of Lions, marine protected areas are located in population sinks; however; if protection measures were taken in the central part, populations would benefit throughout the region via the rescue effect.
ISSN: 1366-9516

hal-01341743
https://hal-univ-perp.archives-ouvertes.fr/hal-01341743
DOI : 10.1111/ddi.12254

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
During the last decade, the interaction of deep processes in the lithosphere and mantle with surface processes (erosion, climate, sea-level, subsidence, glacio-isostatic readjustment) has been the subject of heated discussion. The use of a multidisciplinary approach linking geology, geophysics, geodesy, modelling, and geotechnology has led to the awareness of coupled deep and surface processes. Deep earth dynamics (topography, erosion, tectonics) are strongly connected to natural hazards such as earthquakes, landslides, and tsunamis; sedimentary mass transfers have important consequences on isostatic movements and on georesources, geothermal energy repartitions. The ability to read and understand the link between deep Earth dynamics and surface processes has therefore important societal impacts. Ground-truthing at carefully-selected sites of investigation is imperative to better understand these connections.Due to its youth (<30 Ma) and its subsidence history, the almost land-locked Gulf of Lion–Sardinia continental margins system provides a unique record of sedimentary deposition from the Miocene to present. Due to its high subsidence rate, palaeoclimatic variations, tectonic events and vertical evolution are all recorded here at very high resolution. The late Miocene isolation and desiccation of the Mediterranean, the youngest and most catastrophic event, the Messinian Salinity Crisis (MSC), induced drastic changes in marine environments: widespread deposition of evaporite (gypsum, anhydrite and halite) in the central basin, and intense subaerial erosion along its periphery. These extraordinary mass transfers from land to sea induced strong isostatic re-adjustments that are archived in the sedimentary record and represent a window to the lithospheric rheology and the deep processes.The GOLD (Gulf of Lion Drilling) project, proposes to explore this unique sedimentary record as well as the nature of the deep crustal structure, providing valuable information about the mechanisms underlying vertical motions in basins and their margins.
ISSN: 0264-8172

insu-01197393
https://hal-insu.archives-ouvertes.fr/insu-01197393
https://hal-insu.archives-ouvertes.fr/insu-01197393/document
https://hal-insu.archives-ouvertes.fr/insu-01197393/file/Rabineau%20et%20al.-final-MPG2014_REVISED-FINAL-No-Marked_FINAL%2BFigures.pdf
DOI : 10.1016/j.marpetgeo.2015.03.018

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Seasonal climate forecasts mainly rely on the atmospheric sensitivity to its lower boundary conditions and on their own predictability. Besides sea surface temperature (SST), soil moisture (SM) may be an additional source of climate predictability particularly during boreal summer in the mid-latitudes. In this work, we investigate the role of SM initial conditions on near-surface climate predictability during ten boreal summer seasons using three complementary ensembles of AMIP-type simulations performed with the Arpège-Climat atmospheric general circulation model. First we have conducted an assessment of the SM predictability itself through a comparison of simple empirical SM models with Arpège-Climat. The statistical and dynamical models reveal similar SM prediction skill patterns but the Arpège-Climat reaches higher scores suggesting that it is at least suitable to explore the influence of SM initialization on atmospheric predictability. Then we evaluate the relationships between SM predictability and some near surface atmospheric predictability. While SM initialization obviously improves the predictability of land surface evaporation, it has no systematic influence on the precipitation and near surface temperature skills. Nevertheless, the summer hindcast skill is clearly improved during specific years and over certain regions (mainly north America and eastern Europe in the Arpège-Climat model), when and where the SM forcing is sufficiently widespread and strong. In this case, a significant impact is also found on the occurrence of heat waves and heavy rains, whose predictability at the seasonal timescale is a crucial challenge for years to come.
ISSN: 0930-7575

meteo-00346948
https://hal-meteofrance.archives-ouvertes.fr/meteo-00346948
DOI : 10.1007/s00382-008-0375-9

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : International audience
This paper reports the first outcomes of a research program “Environment and Sustainable Development in the Caribbean space” co-funded by the European Union, the Région Martinique and the Université des Antilles et de la Guyane under the European Union operational programme 2007-2013. Since the middle of the last century, the Caribbean countries, regardless of their great diversity and political fragmentation, are faced with the recurring problem of development. Having explored different paths, they are looking now for new development models. This challenge which becomes obsessive over the decades, is now a major concern: indeed, the Caribbean territories are per se vulnerable and highly exposed to natural risks due to climate change. In addition, this relates to areas where tensions between exploitation and conservation of a rich biodiversity are particularly strong. Based on the promotion of tourism and services as part of an “open regionalism” at the intersection of global and local scales of public action, the current development strategies give rise to a dual approach with, however, rather mixed results: on the one hand, a discursive use of sustainable development, apprehended through its environmental dimension, evidences a new way of looking at the region and a change in the way the region sees itself; on the other hand, a political use of sustainable development through cross-cutting policies, is hindered by the complexity of structures, the multiple levels of action and regulation, and the difficult appropriation of public-policy organization by local communities and people.
Cet article rend compte des premiers résultats d’un programme de recherche « Environnement et développement durable dans l’espace caraïbe » cofinancé par l’Union européenne, la région Martinique et l’Université des Antilles et de la Guyane dans le cadre des programmes opérationnels européens 2007-2013. Il montre que les territoires de la Caraïbe, après avoir exploré plusieurs voies en matière de développement, privilégient désormais des stratégies axées sur le tourisme et les services. S’inscrivant dans un « régionalisme ouvert » au croisement des échelles globale et locale d’intervention en matière d’action publique, ces stratégies débouchent sur une double démarche aux résultats contrastés : d’un côté, une mise en discours du développement durable, appréhendé notamment à travers sa dimension environnementale, témoigne d’un changement de regard sur la région et de celle-ci sur elle-même ; de l’autre, une mise en politique du développement durable à travers des dispositifs à caractère transversal, se heurte à la complexité des structures, à la multiplicité des échelles d’intervention et de régulation ainsi qu’à la difficile appropriation desdits dispositifs par les populations locales.
ISSN: 1240-1307

Droits : info:eu-repo/semantics/OpenAccess
hal-01675012
https://hal.univ-antilles.fr/hal-01675012
https://hal.univ-antilles.fr/hal-01675012/document
https://hal.univ-antilles.fr/hal-01675012/file/NSS_La%20mise%20en%20discours.pdf
DOI : 10.1051/nss/2015043

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND: Numerous studies have linked prenatal traffic-related air pollution exposure to fetal growth. Recently, several studies have suggested exploring this association independently among boys and girls because of potential sex-specific biological vulnerability to air pollution. Residence-based factors can also influence fetal growth by enhancing susceptibility to the toxic effects of air pollution and must also be considered in these relations. OBJECTIVE: We examined sex-specific associations between prenatal air pollution exposure and fetal growth and explored whether they differed by the urban-rural status of maternal residence. METHODS: This study relied on the PELAGIE mother-child cohort (2521 women, Brittany, France, 2002-2006). Fetal growth was assessed through birth weight, head circumference and small weight (SGA) and small head circumference (SHC) for gestational age. Nitrogen dioxide (NO2) concentrations at mothers' homes were estimated by using a land use regression model taking into account temporal variation during pregnancy. Associations between estimated NO2 concentrations and fetal growth were assessed with linear regression or logistic regression models, depending on the outcome investigated. RESULTS: An interquartile range (8.8µgm(-3)) increase in NO2 exposure estimates was associated with a 27.4g (95% CI 0.8 to 55.6) increase in birth weight and a 0.09cm (95% CI 0.00-0.17) significant increase in head circumference, among newborn boys only. Their risks of SGA and SHC were reduced (OR 0.70, 95% CI 0.53-0.92, OR 0.76, 95% CI 0.56-1.03, respectively, for an increase of 8.8µgm(-3)). No statistically significant trends were observed among girls. Urban-rural status modified the effect of air pollution only for SHC and again only for newborn boys. CONCLUSION: Findings from this study confirm the need to consider sex-specific associations between air pollution and fetal growth and to investigate possible mechanisms by which traffic-related air pollution may increase anthropometric parameters at birth
Environmental Research

hal-01205354
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01205354
DOI : 10.1016/j.envres.2015.09.006
PUBMED : 26378737

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Electrical resistivity soundings are used by geophysicists to determine the structure and composition of the Earth's crust and mantle and to explore natural resources (ore, oil, gas, water). Their interpretations in terms of composition and in-situ physical conditions depend mainly on laboratory measurements of electrical conductivity of rocks at simulated crustal conditions of temperature, pressure, saturation and pore pressures. These measurements present a numbers of limitations, in particular, in the case where conductive pore fluids are present, as in the case of deep reservoir conditions, where temperature exceeds 250 A degrees C. Here, we present a new cell capable of measuring electrical conductivity of large saturated samples at confining pressure up to 200 MPa, pore pressure up to 50 MPa, and temperature up to 500 A degrees C. The measurement cell has been developed in a commercial, internally heated, gas pressure apparatus (Paterson press). It is based on the concept of "guard ring" electrode, which is adapted to samples that are jacketed by a very conductive, metallic material. Numerical modeling of the current flow in the electrical cell allowed defining the optimal cell geometry. Calibration tests have been performed on Fontainebleau sandstones saturated with electrolytes of different conductivities, up to 350 A degrees C. The resulting electrical formation factor and temperature dependence of electrical conductivity are in very good agreement with previous studies. This new cell will improve the exploration and exploitation of deep fluid reservoirs, as in unconventional, high enthalpy geothermal fields. In particular, the investigations address possible effects of fluid-rock interactions on electrical resistivity of a reservoir host rock.
ISSN: 0169-3913

hal-00681997
https://hal.archives-ouvertes.fr/hal-00681997
DOI : 10.1007/s11242-011-9846-2

Résumé : L'agriculture actuelle est impliquée dans de multiples problématiques environnementales, sociales et économiques, aux échelles locales et globales. En agronomie, de nombreux travaux à l'échelle du champ et de l'exploitation visent aujourd'hui à concevoir des systèmes de culture et des systèmes de production en lien avec ces problématiques. En revanche, peu de travaux portent sur la conception et l'évaluation de systèmes agricoles à l'échelle du territoire, alors que cette échelle apparaît pourtant incontournable pour faire face à des enjeux de développement durable. Pour combler ce manque, nous proposons un ensemble méthodologique permettant i) de simuler les conséquences de scénarios de politiques agricoles sur les choix d'assolement des agriculteurs, décrits individuellement, en modélisant l'évolution de leurs système de production et ii) d'évaluer l'impact de ces changements d'assolements à l'échelle du territoire, à l'aide d'indicateurs qui apportent de l'information spatiale sur la contribution de l'agriculture au développement durable. L'ensemble méthodologique proposé débute par la construction d'une typologie des exploitations agricoles du territoire sur la base de la similarité de leur assolement. Parallèlement, l'adaptation d'indicateurs à l'échelle du territoire permet d'évaluer les impacts des externalités des systèmes de culture en mobilisant des procédures de changements d'échelles. Un modèle bioéconomique générique, multi-échelle, spatialement explicite, appelé MOSAICA, qui utilise la typologie et les indicateurs d'impact de l'agriculture à l'échelle régionale, est créé pour produire des mosaïques de systèmes de culture et évalue leur contribution au développement durable du territoire. Ce modèle, couplé à un itinéraire de définition de scénarios exploratoires et normatifs permet de tester l'impact de différents types de leviers agronomiques, socio-économiques, environnementaux, organisationnels et techniques sur les choix des exploitants et in fine sur la contribution de la mosaïque de systèmes de culture au développement durable du territoire. Nous avons appliqué cet ensemble méthodologique à la conception de scénarios de développement agricoles durables en Guadeloupe. Nous avons dans un premier temps développé une typologie des systèmes de production comprenant huit types distincts et relevant de processus décisionnel différents. Puis nous avons adapté à l'échelle du territoire 19 indicateurs pour l'évaluation des mosaïques de systèmes de culture. L’évaluation de la mosaïque actuelle nous a permis de repérer de faibles niveaux de contribution aux enjeux d’autonomie alimentaire et énergétique. Différents scénarios normatifs et exploratoires intégrant des leviers de changement de la mosaïque ont été testés avec MOSAICA. Les évaluations réalisées nous ont permis d'identifier que des leviers agronomiques comme le développement du maraîchage sans intrants chimiques et des leviers sociaux comme la formation de main-d'oeuvre supplémentaire permettraient d'améliorer la contribution de l’agriculture au développement durable du territoire Guadeloupéen. La modélisation mécaniste de l’évolution du territoire agricole permet d'intégrer des connaissances sur la localisation, les performances, les impacts des systèmes de culture et sur les processus décisionnels des exploitants régissant l’orientation productive et le fonctionnement des exploitations. Cette démarche permet de visualiser les changements de système de culture et leurs impacts de manière spatialement explicite, ce qui permet de générer des connaissances sur les leviers susceptibles de faire évoluer positivement l'agriculture du territoire. La démarche et les outils mis en oeuvre sont donc particulièrement utiles pour l'aide à la décision publique pour améliorer la durabilité de l'agriculture dans son ensemble.
Current agricultural systems are responsible for many different environmental, social and economic issues at both local and global scales. Agricultural sciences have contributed to the design of several methods at the farm and field scale in order to prototype cropping systems and farming systems to address these issues. However, few methods have been designed at the regional scale, while this scale seems to be essential in order to address these issues. In order to fill this gap, we here propose a new methodological framework for i) simulating the consequences of policy changes on farmer's cropping plan, described individually, by modeling the evolution of farming systems and to ii) assess the impacts of cropping system changes at the regional scale, with a set of indicators that generate spatially explicit information on the contribution of agriculture to sustainable development. The methodological framework starts with the design of a farm typology over the territory based on the similarity of farmer's crop acreages. In parallel, a set of indicators is adapted to the landscape scale in order to assess the impacts of cropping system externalities by integrating a set of scale change procedures. A generic, multi-scale, spatially explicit bioeconomic model called MOSAICA, which uses the farm typology and the indicators, is created for generating cropping system mosaics and assessing their contribution to sustainable development. This model coupled to a scenario approach composed of exploratory and normative scenarios can simulate the impact of several types of agronomic, socio-economic, environmental, organizational and technical levers of change on the farmer's choices in terms of cropping systems and in fine the impacts of new cropping system mosaics on the contribution to sustainable development of territories. We applied this methodological framework for building scenarios of sustainable agricultural development in Guadeloupe. We first developed a typology of farming systems encompassing eight types of farming systems that revealed several different farmer's decision processes. Then, we developed 19 indicators to assess cropping system mosaics. The assessment of the current cropping system mosaic showed low levels of response of the current mosaic to economic and social issues especially the food and energy self-sufficiency. Different normative and exploratory scenarios integrating levers of change have been simulated with MOSAICA. The assessment of cropping system mosaics from these scenarios highlighted the positive effect of agronomic levers of change such as organic crop-gardening and social levers such as the vocational training of supplementary workforce for improving the contribution of agriculture to sustainable development of the guadeloupean territory. The mechanistic modeling of the agricultural territory allows us to integrate a wide range of knowledge on the location of cropping systems, their levels of performance , their impacts and the decision process of farmer's that drive the farming system characteristics and the farm functioning. This methodological framework helps visualize the cropping system changes at the regional scale and their associated impacts at the landscape scale which is helpful in order to produce knowledge on the levers of change that can improve the response of local agriculture to local and global issues. The framework and tools designed are particularly useful for decision-aid on the future levels of contribution of agriculture to sustainable development.

http://www.theses.fr/2015AGUY0823/document

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
The outstanding exposure of deformation bands in a multilayer sequence of the Orange quarry, Provence, France, motivates a study investigating the development and controls of deformation band geometries by field mapping combined with finite element modeling. Field mapping yields new insights into angular relations between, and evolution of, the deformation bands as well as provides input parameters for the setup and boundary conditions of the numerical simulations using ADELI 2D. In particular, reverse-sense deformation bands are found to have developed within three of the four exposed layers of the multilayer stack with similar orientations to bedding, indicating layer-parallel contraction. Numerical simulations, carried out as a parametric study to investigate the influence on deformation band development and geometry, successfully reproduce the sequential development of deformation bands in the three layers as seen in the field as well as recreate the observed angular geometries of similar to 39 degrees to the maximum compression. This angular relationship is put into context with observations from other field studies and theoretical values to explore controls of deformation band orientations. Furthermore, band localization is impeded in the model by increased layer cohesive strength, demonstrating the importance of host-rock property variations on where localization of bands within the multilayer sequence. Results from both field investigation and numerical simulations are consistent with regional tectonics, where the strata underwent gentle folding due to thrust faulting at depth, and bring further insight into the development and geometry of deformation bands in both extensional and contractional tectonic regimes.
ISSN: 0148-0227

hal-00639452
https://hal.archives-ouvertes.fr/hal-00639452
DOI : 10.1029/2011JB008365

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Contractional deformation of highly porous sandstones is poorly explored, as compared to extensional deformation of such sedimentary rocks. In this work we explore the highly porous Aztec Sandstone in the footwall to the Muddy Mountain thrust in SE Nevada, which contains several types of deformation bands in the Buffington tectonic window: 1) Distributed centimeter-thick shear-enhanced compaction bands (SECBs) and 2) rare pure compaction bands (PCBs) in the most porous parts of the sandstone, cut by 3) thin cataclastic shear-dominated bands (CSBs) with local slip surfaces. Geometric and kinematic analysis of the SECBs, the PCBs and most of the CSBs shows that they formed during ∼E–W (∼100) shortening, consistent with thrusting related to the Cretaceous to early Paleogene Sevier orogeny of the North American Cordilleran thrust system. Based on stress path modeling, we suggest that the compactional bands (PCBs and SECBs) formed during contraction at relatively shallow burial depths, before or at early stages of emplacement of the Muddy Mountains thrust sheet. The younger cataclastic shear bands (CSBs, category 3), also related to E–W Sevier thrusting, are thinner and show larger shear offsets and thus more intense cataclasis, consistent with the initiation of cataclastic shear bands in somewhat less porous materials. Observations made in this work support earlier suggestions that contraction lead to more distributed band populations than what is commonly found in the extensional regime, and that shear-enhanced compaction bands are widespread only where porosity (and permeability) is high.
ISSN: 0191-8141

hal-01171854
https://hal.archives-ouvertes.fr/hal-01171854
DOI : 10.1016/j.jsg.2015.02.014

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
An exploration 3D seismic data set from the Gjallar Ridge off mid-Norway images a giant fluid seep structure 3 × 5 km wide, which connects to late Palaeocene magmatic sills at depth. Two of the pipes that have developed as hydrothermal vents reach all the way to the modern seafloor implying that they either were active much longer than the original hydrothermal activity or have been reactivated. We combine detailed seismic analysis of the northern pipe and sandbox modeling to constrain pipe initiation and propagation. Although both the seismic data and the sandbox models suggest that fluids at depth are focused through a vertical conduit, sandbox models show that fluids ascend and reach a critical depth migration where focused migration abruptly transforms into distributed fluid flow through unconsolidated sediments. This indicates that at this level the sediments are intensely deformed during pipe propagation, creating a V-shaped structure, i.e. an inverted cone at depth and a positive relief anomaly, 5 to 10 m high, at the seafloor, which is clearly identified on 3D seismic data. Comparison of the geometries observed in sandbox modeling with the seismically observed geometries of the Giant Gjallar Vent suggests that the Giant Gjallar Vent may be a proto-fluid seep at an early stage of its development, preceding the future collapse of the structure forming a seafloor depression. Our results imply that the Gjallar Giant Vent can be used as a window into the geological processes active in the deep parts of the Vøring Basin.
ISSN: 0025-3227

hal-00772465
https://hal.archives-ouvertes.fr/hal-00772465
DOI : 10.1016/j.margeo.2012.08.010

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A comprehensive inventory of global biodiversity would be greatly improved by automating methods for species delimitation. The Automatic Barcode Gap Discovery method, the Poisson tree processes algorithm and the Generalized mixed Yule coalescent model have been proposed as means of increasing the rate of biodiversity description using single locus data. We applied these methods to explore the diversity within the Aglaopheniidae, a hydrozoan family with many species widely distributed across tropical and tem perate oceans. Our analyses revealed widespread cryptic diversity in this family, almost half of the morpho species presenting several independent evolutionary lineages, as well as support for cases of synonymy. For two common species of this family, Lytocarpia brevirostris and Macrorhynchia phoenicea, we compared the outputs to clustering analyses based on microsatellite data and to nuclear gene phylo genies. For L. brevirostris, microsatellite data were congruent with results of the species delimitation methods, revealing the existence of two cryptic species with Indo Pacific distribution. For M. phoenicea, all analyses confirmed the presence of two cryptic species within the South Western Indian Ocean. Our study suggests that the diversity of Aglaopheniidae might be much higher than assumed, likely related to low dispersal capacities. Sequence based species delimitation methods seem highly valuable to reveal cryptic diversity in hydrozoans; their application in an integrative framework will be very useful in describing the phyletic diversity of these organisms.
ISSN: 1055-7903

hal-01359407
https://hal.archives-ouvertes.fr/hal-01359407
https://hal.archives-ouvertes.fr/hal-01359407/document
https://hal.archives-ouvertes.fr/hal-01359407/file/Postaire-etal2016MolPhylEvol_sp_delim_hydraires_HAL.pdf
DOI : 10.1016/j.ympev.2016.08.013

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
BACKGROUND: The use of pesticides and the related environmental contaminations can lead to human exposure to various molecules. In early-life, such exposures could be responsible for adverse developmental effects. However, human health risks associated with exposure to complex mixtures are currently under-explored. OBJECTIVE: THIS PROJECT AIMS AT ANSWERING THE FOLLOWING QUESTIONS: What is the influence of exposures to multiple pesticides on the metabolome? What mechanistic pathways could be involved in the metabolic changes observed? METHODS: Based on the PELAGIE cohort (Brittany, France), 83 pregnant women who provided a urine sample in early pregnancy, were classified in 3 groups according to the surface of land dedicated to agricultural cereal activities in their town of residence. Nuclear magnetic resonance-based metabolomics analyses were performed on urine samples. Partial Least Squares Regression-Discriminant Analysis (PLS-DA) and polytomous regressions were used to separate the urinary metabolic profiles from the 3 exposure groups after adjusting for potential confounders. RESULTS: The 3 groups of exposure were correctly separated with a PLS-DA model after implementing an orthogonal signal correction with pareto standardizations (R2 = 90.7% and Q2 = 0.53). After adjusting for maternal age, parity, body mass index and smoking habits, the most statistically significant changes were observed for glycine, threonine, lactate and glycerophosphocholine (upward trend), and for citrate (downward trend). CONCLUSION: This work suggests that an exposure to complex pesticide mixtures induces modifications of metabolic fingerprints. It can be hypothesized from identified discriminating metabolites that the pesticide mixtures could increase oxidative stress and disturb energy metabolism.
ISSN: 1932-6203

inserm-00863407
http://www.hal.inserm.fr/inserm-00863407
http://www.hal.inserm.fr/inserm-00863407/document
http://www.hal.inserm.fr/inserm-00863407/file/journal.pone.0064433.pdf
PUBMED : 23704985

Éditeur(s) : HAL CCSD IGI Global
Résumé : International audience
The social behavior of individuals is an important factor of the transmission and the evolution of many diseases. As such, epidemic studies have attempted to integrate social aspects in dissemination modeling. Since the pioneering works of Klovdahl on AIDS in 1985, epidemiological investigations and interventions increasingly focus on social networks. Significant factors of the transmission and outbreak of many infectious diseases are the structure and nature of human interactions. Network-based modeling approaches have found various applications in epidemiology as a simple yet efficient way to represent the complexity of human relationships implicated in dissemination processes. However, most results have been obtained by considering social networks as steady stage structures. Evolving networks have not been explored. The objective is first to give an overview of network-based modeling attempts in epidemiology to analyze and understand the dissemination processes with an emphasis on dynamic networks. The authors approach is designed to understand the impact of social links dynamics on epidemic spread. The authors present the results obtained by combining network evolution patterns (link creation and deletion) and a typical epidemic model. The speed of link dynamics and the infection time strongly influence the occurrence and value of the epidemic peak.
ISSN: 1947-8186

hal-00700105
https://hal.archives-ouvertes.fr/hal-00700105
DOI : 10.4018/jismd.2012070103

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Tilt fluctuations can potentially reflect the response of hydrosystems to important rainfall. In this context, long baseline tiltmeters have been installed in an underground tunnel penetrating the Fontaine de Vaucluse karst to study the medium deformation related to solicitations exerted by water infiltrating the hydrosystem. The instruments monitor the tilt as well as its spatial variation. Northward tilts reaching a 1 μrad amplitude are observed consecutively to rainfalls. The tilt amplitude is highly correlated with the Fontaine de Vaucluse outlet flow fluctuations. The measured tilt signal is also relatively homogeneous over a 150 m length. Different types of structure likely to produce such observations are tested in order to identify their location with respect to the tiltmeters, their dimension as well as the amount of water level variation in the structure. Following rainfalls, the infiltration of water modifies the pore pressure, inducing a medium deformation. The hypothesis of an homogeneous surface loading on the Vaucluse plateau is first refuted since the related tilt is much lower than the one measured. The water supplied by rainfalls has to accumulate in discontinuities in order to generate a higher tilt. So, the deformation related to a pressure exerted on a fracture filled by water is assessed. A first study reveals the interest of the tilt homogeneity information that constrains strongly the fracture properties. Thus, the fracture must be located at a distance more than a few hundreds metres from the tiltmeters in order to produce a tilt homogeneous in space. If the fracture is initially dry, it must also be filled on a height higher than 150 m consecutive to a rainfall in order to generate a tilt amplitude in the same magnitude as the one measured. Then, we explore the influence of water level variations on the tilt produced by a fracture located at the interface between the saturated and unsaturated zones, which are thereby permanently flooded. Since several parameters of that model satisfactorily explain the field observations, we discuss how simultaneous geodetical observations could provide complementary information that would further constrain the geometry of the structure at the origin of the medium deformation.
ISSN: 0956-540X

insu-01408482
https://hal-insu.archives-ouvertes.fr/insu-01408482
https://hal-insu.archives-ouvertes.fr/insu-01408482/document
https://hal-insu.archives-ouvertes.fr/insu-01408482/file/Lesparre-2017.pdf
DOI : 10.1093/gji/ggw446