Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The increased expression of the Disintegrin and Metalloprotease ADAM12 has been associated with human cancers, however its role remain unclear. We have previously reported that ADAM12 expression is induced by the transforming growth factor, TGF-β and promotes TGF-β-dependent signaling through interaction with the type II receptor of TGF-β. Here we explore the implication of ADAM12 in TGF-β-mediated epithelial to mesenchymal transition (EMT), a key process in cancer progression. We show that ADAM12 expression is correlated with EMT markers in human breast cancer cell lines and biopsies. Using a non-malignant breast epithelial cell line (MCF10A), we demonstrate that TGF-β-induced EMT increases expression of the membrane-anchored ADAM12L long form. Importantly, ADAM12L overexpression in MCF10A is sufficient to induce loss of cell-cell contact, reorganization of actin cytoskeleton, up-regulation of EMT markers and chemoresistance. These effects are independent of the proteolytic activity but require the cytoplasmic tail and are specific of ADAM12L since overexpression of ADAM12S failed to induce similar changes. We further demonstrate that ADAM12L-dependent EMT is associated with increased phosphorylation of Smad3, Akt and ERK proteins. Conversely, inhibition of TGF-β receptors or ERK activities reverses ADAM12L-induced mesenchymal phenotype. Together our data demonstrate that ADAM12L is associated with EMT and contributes to TGF-β-dependent EMT by favoring both Smad-dependent and Smad-independent pathways
ISSN: 1932-6203

hal-01207281
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207281
DOI : 10.1371/journal.pone.0139179
PUBMED : 26407179

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Au Belize, le projet de construction d’une nouvelle capitale apparait au début des années 1960, juste après la tragédie de l’ouragan Hattie (octobre 1961) qui a détruit une grande partie de la capitale coloniale, Belize City. Belmopan, située au centre géographique du Belize, devait être le nouveau visage moderne du pays, le symbole d’une jeune nation sur le chemin de son indépendance (1981), la garantie d’une société mieux intégrée en termes territoriaux et de population, le fer de lance du développement économique du pays. Néanmoins, depuis sa naissance, la ville peine à se développer et se peupler et Belize City, sur la côte Caraïbe, continue à jouer le rôle de capitale non officielle du pays. L’histoire de Belmopan, de sa planification initiale à sa croissance actuelle, me permettra d’interroger la difficile émergence d’une nation indépendante, dont le double ancrage caribéen et centre-américain se superpose à une ethnicisation de la société.
In Belize, the project to build of a new capital appeared at the beginning of the 1960s, just after the tragedy of hurricane Hattie (October 1961), which destroyed a large part of the colonial capital, Belize City. Belmopan, located at the geographical center of Belize, should become the new modern face of the country, the symbol of a young nation on its way to independence (1981), the guarantee of a better territorial and demographic integrated society, the spearhead of the economic development of the country. Nevertheless, since its birth, the city has failed to expand and Belize City, on the Caribbean coast, is still the non-official capital of the country. The history of Belmopan, from its initial planning to its current growth, will give me the opportunity to question the difficult emergence of an independent nation, whose double Caribbean and Central-American belonging produces the ethnicization of the society.
Belmopan
Belize
Caraïbes

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.5733
http://journals.openedition.org/etudescaribeennes/5733

Éditeur(s) : HAL CCSD
Résumé : International audience
This paper aims to demonstrate that the use of a modern tool, the GPS (Global PositioningSystem), can significantly improve our understanding of active faults and their seismic cycle. We focus on theNorth-Caribbean plate boundary, specifically in the Dominican Republic, and present some quantificationsof velocities that result from measurements that have been made possible by the instrumentation of the areaby a consortium of researchers from France, the USA and the Dominican Republic, since 1994. Then, wediscuss the velocities in terms of seismic potential of the regional major faults.
Cet article présente comment l'utilisation d'un outil moderne, le GPS (Global Positioning System) peut apporter des éléments significatifs dans la connaissance des failles actives et de leur cycle sismique. Nous nous intéressons ici à la frontière de plaque Nord-Caraibe, en République Dominicaine, et présentons des quantifications de vitesses de déplacement obtenues grâce à l'instrumentation de la zone depuis 1994 par un groupe de chercheurs français, états-uniens et dominicains. Les résultats sont ensuite discutés en termes d'aléas sismologiques des failles majeures.
ISSN: 2551-6116

hal-01537725
https://hal.univ-antilles.fr/hal-01537725
https://hal.univ-antilles.fr/hal-01537725/document
https://hal.univ-antilles.fr/hal-01537725/file/Mazabraud-et-Forissier-2007.pdf

Éditeur(s) : HAL CCSD American Society for Investigative Pathology
Résumé : International audience
Based on both experimental and clinical data, tamoxifen has been proposed to have cardiovascular benefits, although the mechanism(s) contributing to that protective effect are still poorly understood. In vitro experiments demonstrated that tamoxifen elicits its transcriptional effect through estrogen receptor (ER) α, but other targets can participate in its actions. However, although tamoxifen selectively activates the activating function (AF)-1 of ERα, we recently showed that this ERα subfunction is dispensable for the atheroprotective action of 17β-estradiol (E2), the main ligand of ERs. The goal of the present work is to determine to which extent ERα and its AF-1 mediate the vasculoprotective action of tamoxifen. Our data confirm that tamoxifen exerts an atheroprotective action on low density lipoprotein receptor (LDL-r(-/-)) female mice, but, in contrast to E2, it fails to accelerate reendothelialization after carotid electric injury. Tamoxifen and E2 elicit differences in gene expression profiles in the mouse aorta. Finally, the atheroprotective action of tamoxifen is abrogated in ERα(-/-)LDL-r(-/-) mice and in LDL-r(-/-) mice selectively deficient in ERαAF-1 (ERαAF-1(0/0)LDL-r(-/-)). Our results demonstrate, for the first time to our knowledge, that tamoxifen mediates its actions in vivo through the selective activation of ERαAF-1, which is sufficient to prevent atheroma, but not to accelerate endothelial healing.
ISSN: 0002-9440

hal-00874317
https://hal.archives-ouvertes.fr/hal-00874317
DOI : 10.1016/j.ajpath.2013.03.010
PUBMED : 23669343

Éditeur(s) : Université de Bretagne Occidentale
Résumé : The objective of the present work is to study the formation of the passive continental margins of the Central Segment of the South Atlantic, most particularly the Congo and Angola margins. We propose a combined approach, which integrates structural constraints based on geological cross-sections (based on seismic data) and global constraints based on plate kinematic reconstructions. The structural study is based on : i) MCS and refraction data collected during the ZaiAngo programme (a joint project conducted by Ifremer and Total) ; ii) proprietary, industrial seismic data (courtesy of Total) from the Angola margin and iii) on all available seismic lines from the Africa and Brazil conjugated margins, between Walvis Ridge and the Equatorial Fracture Zones. Based on theses data, three structural domains (continental, transitional and oceanic) have been defined, the major characteristics of which are : Crustal thinning occurs abruptly, mostly below the continental slope, over a lateral distance of less than 50 km. The top of the crust deepens as the Moho shallows. Only a few extensional structures are observed ; tilted blocks are very few (one or two, depending on the profile), found only on the upper part of the slope and sealed by a discordance prior to salt deposition. The transitional domain is characterized by the existence of a pre-salt basin lying over a thin crustal layer. No tilted blocks are observed in this domain and reflectors within the pre-salt sediment series are parallel to the base of the Aptian salt, over distances greater than 100 km, precluding the possibility of any significant deformation that would imply large horizontal motions. Two types of crust are observed in the transitional domain. "Type I" crust is found below the undeformed pre-salt sediment series located below the eastern part of the basin ; it is characterized by an upper layer of thickness greater than 5 km and a abnormal velocity layer (7.2 - 7.6 km/s), up to 6 km thick. "Type II" crust is less than 5 km thick and found below the salt compressive front that affects the western part of the basin. The salt cover is continuous (no erosion surface is observed), from the continental shelf to the western termination of the basin. Salt was not deposited in a confined environment (like in the Mediterranean), but in a shallow water, lagunal environment. This imposes the zero-level and constrains the paleo-bathymetry at the time of salt deposition, which dates the latest stage of margin formation. Understanding the formation of a margin cannot be approached without studying the homolog margin. Therefore, it is of major importance to reconstruct the closure of the ocean bordered by these homolog margins and take into account the constraints imposed by the kinematic reconstructions on the lateral motions of the lithospheric plates. In order to assess the relative position of the plates at the ocean closure (prior to crustal thinning), a global study was thus performed, integrating all geophysical and geological constraints, in the ocean and on land. The role of african intra-plate deformation and its limits and their consequences have been thoroughly studied. To juxtapose the margins of the central segment of the Southern Atlantic, it is all the margins bordering the Equatorial Atlantic that need to be adjuste precisely. The kinematic study of this last region shows that the reconstruction obtained are reliable, unambiguous with a quantifiable precision The best fitting poles (obtained using the PLACA software), show that it is impossible to close the margins beyond the superposition of the salt fronts, from the Angola and Brazil margins. The geological cross-sections based on seismic data from the homolog margins indicate that a 330 km wide basin with thin (< 12 km) crust was present at the time of the fit. This basin cannot result from horizontal movement related to pure stretching or simple shear, or any model implying conservative volume. This conclusion is consistent with the existence of presalt reflectors parallel to the salt layer wich extends to the platform: the formation of the pre-salt basin must be related to vertical motions. The scenario that we propose for the evolution of the Congo-Angola margin consist in four stages: the first phase corresponds to extensional deformation limited to the few tilted blocks observed on the upper part of the slope. During the second phase, the main crustal thinning occurs, vertical motions prevailes, resulting in the formation of the continental slope and in the subsidence of the basin. The third phase corresponds to the first stress striction: deformation is concentrated in a limited section of the basin, which corresponds to the salt compression front. A proto-oceanic crust is formed, probably composed of thinned continental crust intruded by mantle material. The second stress striction corresponds to the finale phase, resulting in oceanisation senso stricto. The evolution described shows that we can not apply conservative models for margin formation (such as McKenzie and Wernicke or any of their avatars). In order to explain this thinning, one should investigate non-conservative models (implying geochemical transformation, small scale convection, intrusion...) such as those proposed in marginal or continental basins with no horizontal movments.
Ce travail de thèse aborde la formation des marges continentales passives dans le segment central de l'océan Atlantique Sud (plus particulièrement au Congo et en Angola), en intégrant une étude en coupe (étude structurale à partir des coupes sismiques) et une étude en plan (étude cinématique). L'étude structurale de la marge a été réalisée à partir des données de sismique réflexion et réfraction de la campagne Zaïango et d'une compilation de données sismiques réflexion existantes sur toutes les marges africaine et brésilienne entre les zones de fracture équatoriales et la ride de Walvis. L'interprétation de ces données a permis d'individualiser la structure de la marge en trois domaines : continental, transitionnel et océanique et de déterminer quelques points majeurs sur la structuration de la marge. L'amincissement est abrupt, localisé dans la zone de pente continentale et restreint à 50 km. La marge montre peu de structures distensives : seuls un ou deux blocs basculés sont observés en haut de pente continentale. Le domaine transitionnel est caractérisé par la géométrie particulière de la sédimentation anté-salifère, l'absence de blocs basculés et la faible épaisseur de croûte. La couche sédimentaire anté-salifère montre des réflecteurs plans jusqu'à la base du sel, continus sur 100 km, éliminant toutes possibilités de déformation du socle pendant et après son dépôt. La croûte du domaine transitionnel peut-être divisée en deux types : une croûte de type I sur laquelle se déposent les sédiments non déformés, et une croûte de type II sur laquelle se superposent les limites du « front compressif salifère » bien exprimé dans les séries postsalifères. Enfin le sel, que l'on observe depuis la plate-forme jusqu'au bassin profond, ne se dépose pas dans un bassin confiné (comme en Méditerranée) mais à un niveau proche de 0 m (ressemblant probablement à un dépôt de type lagunaire) et donne la paléo-bathymétrie au moment de son dépôt qui marque la fin de la période de formation de la marge. La compréhension de la genèse d'une marge ne peut être approchée sans son homologue. Cette simple constatation, cette évidence, montre toute l'importance que l'on doit apporter à la reconstruction cinématique initiale de l'océan qui borde ces marges homologues et aux contraintes imposées par les reconstructions cinématiques sur les mouvements horizontaux des plaques lithosphériques. Afin d'étudier la position des marges au moment de cette fermeture, c'est-à-dire avant amincissement, une étude globale intégrant l'ensemble des données disponibles, géophysiques et géologiques, océaniques et continentales, a été réalisée. Le rôle de la déformation intraplaque africaine, ses limites et leurs conséquences a, en particulier, été l'objet d'une attention poussée. Pour juxtaposer les marges du segment central, ce sont toutes les marges de l'océan Atlantique Equatorial qui doivent être ajustées précisément. L'étude cinématique réalisée de la région équatoriale montre que l'on obtient une reconstruction fiable et sans ambiguïté, avec une précision que l'on peut quantifier. Les pôles issus de cette étude (et calculés avec le Logiciel PLACA) indiquent qu'il est impossible d'obtenir une fermeture plus serrée que celle qui conduit à la superposition des fronts salifères brésilien et angolais : les coupes issues de la sismique réflexion des deux marges indiquent qu'il subsiste un bassin aminci, large de plus de 330 km et dont la croûte n'excède jamais 13 kilomètres d'épaisseur. La formation de ce bassin ne peut résulter de mouvements horizontaux, ce qui exclut un amincissement par étirement (pure stretching) ou par l'existence d'une faille de détachement (simple shear) ou par quelque modèle conservatif que ce soit. Cette constatation corrobore l'observation de la présence d'horizons anté-salifère parallèles, entre eux et au sel, couche salifère que l'on retrouve sur la plate-forme : la création de ce bassin anté-salifère ne peut être que liée à un mouvement vertical. Le schéma d'évolution que nous proposons à partir des données structurales et des contraintes cinématiques présente quatre étapes : le premier stade correspond à une phase de déformation distensive limitée aux quelques rares blocs basculés observés en haut de pente continentale. C'est durant la deuxième étape que se déroule la phase d'amincissement principal, les mouvements verticaux prévalent, aboutissant à la formation de la pente continentale et à la subsidence du bassin. La troisième phase correspond à une première striction des contraintes : la déformation se concentre sur une partie réduite du bassin, coïncidant avec le front salifère compressif. Une proto-croûte océanique se forme, probablement composée de croûte continentale amincie et intrudée de matériel mantellique. La seconde striction correspond à la phase finale de formation de la marge et aboutit à l'océanisation sensu stricto. L'étude cinématique et la description de l'évolution de la marge à partir des données sismiques montre donc que l'on ne peut envisager l'application d'un modèle de genèse des marges avec conservation de volume (type McKenzie ou Wernicke et leurs avatars) : pour expliquer l'amincissement du bassin, il faudrait probablement nous intéresser aux modèles non-conservatifs (impliquant transformation, convection à petite échelle, ...) qui sont déjà invoqués pour la formation des bassins marginaux ou continentaux, sans mouvements horizontaux.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2003/these-82.pdf
http://archimer.ifremer.fr/doc/00000/82/

Éditeur(s) : HAL CCSD
Résumé : Ctenophores are one of the four animal phyla positioned outside from the Bilateria. Most ctenophore species are planktonic and gelatinous, and are easily recognisable by their eight comb rows used for swimming. Ctenophore systematics remains nowadays poorly understood. Anatomical characters do not help much in placing them within the animal tree, and similarly the grounds for establishment of their internal phylogeny as well as delimitation of species are notoriously weak due to a paucity of informative morpho-anatomical characters. Until now, the use of molecular data has failed to improve significantly this situation. The aim of this PhD thesis was to bring a contribution to our understanding of ctenophore evolution at different taxonomic scales. At the metazoan level, the position of ctenophores was addressed using a phylogenomic approach. Taxonomic sampling was significantly improved through sequencing and assembly of transcriptomes of 22 non-bilaterian species (belonging to ctenophores, cnidarians and sponges). Two independent datasets were analysed, one consisting in an update of an existing supermatrix of 128 genes, the other one (4235 genes) having been entirely built de novo, thanks to a newly-devised semi-automated protocol intended to eliminate all major potential causes of artefacts (contaminations, paralogies, missing data). Results clearly contradict recent phylogenomic studies which claimed Ctenophora to be the most early-diverging animal lineage, our analyses instead supporting Porifera as the sister-group to other metazoans. The exact position of ctenophores remains however uncertain at this stage, different conditions of analyses yielding three contradictory hypotheses as open possibilities. At the intra-phyletic level, analyses of a ADNr 18S and ITS (internal transcribed spacers) dataset, together with study of duplicated genes and the results of phylogenomic analyses, allowed resolving most phylogenetic relationships between ctenophore orders and families, including the placement of the ctenophore tree root. Finally, at smaller taxonomic scale, in-depth comparison between two species of the genus Pleurobrachia using immunohistochemistry demonstrates the potential of these techniques for uncovering new structural “micro-anatomical” characters useful for diagnosis and identification of ctenophore species. It is our hope that this work will contribute to improving the systematics of a poorly known phylum of great importance for understanding early animal evolution.
Les cténophores représentent l’un des quatre embranchements animaux extérieurs aux Bilateria. La majoritédes espèces sont planctoniques et gélatineuses, et sont reconnaissables à leurs huit rangées de peignes dont lebattement permet la nage. Leur systématique est encore de nos jours mal comprise. L'anatomie descténophores offre peu de caractères aussi bien pour placer la lignée dans l’arbre des métazoaires, que pourétablir les relations de parenté au sein de l’embranchement et délimiter les espèces, et jusqu’à présent lesdonnées moléculaires n’ont pas permis de résoudre ces problèmes de manière satisfaisante. L’objectif de cetravail de thèse est de contribuer à améliorer notre compréhension de l'évolution des cténophores àdifférentes échelles taxonomiques. A l’échelle des métazoaires, la position phylogénétique des cténophores aété abordée par une approche phylogénomique. Un effort significatif a été réalisé pour améliorerl’échantillonnage taxonomique à travers le séquençage et l’assemblage des transcriptomes de 22 espèces denon-Bilateria (cténophores, cnidaires, spongiaires). Deux jeux de données indépendants ont été analysés, lepremier représentant une mise à jour d’une supermatrice existante de 128 gènes ; le second (4235 gènes)ayant été entièrement construit de novo via un protocole original comportant la mise au point de nouvellesméthodes pour traiter de manière semi-automatisée les principales sources potentielles d’artéfact(contaminations, paralogies, données manquantes). Les résultats contredisent certaines études récentes enmontrant que les spongiaires et non les cténophores représentent le groupe-frère des autres métazoaires. Laposition exacte de ces derniers reste à ce stade incertaine (trois options se présentant suivant les analyses). Al’échelle intra-phylétique, l'analyse d'un jeu de données comprenant les marqueurs ADNr 18S et InternalTranscribed Spacers (ITS), associée à des analyses de gènes dupliqués chez les cténophores et aux analysesphylogénomiques précédentes, a permis de résoudre une grande partie des relations phylogénétiques entre lesordres et les familles de cténophores, tout en permettant de préciser la position de la racine. Enfin, à uneéchelle taxonomique plus fine, une comparaison approfondie entre deux espèces du genre Pleurobrachia aumoyen de marquages immunohistochimiques montre le potentiel de ces techniques comme source denouveaux caractères structuraux « micro-anatomiques » à valeur diagnostique pour la délimitation etl’identification des espèces de cténophores. En conclusion, ce travail se veut une contribution au progrès dela systématique d’un embranchement encore méconnu et d’une grande importance pour la compréhensiondes évènements anciens de l’évolution animale.
https://tel.archives-ouvertes.fr/tel-01165014

NNT : 2014PA066448
tel-01165014
https://tel.archives-ouvertes.fr/tel-01165014
https://tel.archives-ouvertes.fr/tel-01165014/document
https://tel.archives-ouvertes.fr/tel-01165014/file/these_archivage_3158995o.pdf

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999 15-19 octobre 1999
Résumé : The development of the FAD gave rise to technical problems owing to their conception, their setting spot and of their utilisation. Failings generated by the unreliability of components or the uncertain repair precariousness, those can prove to be here more and more expensive with the progression of the ageing of devices and reasons of their loss. For as various domains that aerospace or the fishing deck layout, the engineering has functional analysis tools that permit to reduce conception uncertainties of systems by the mean of a hierarchical classification of function values of components. The application of one of these techniques, the FMEA, Failure Mode and Effects Analysis, to the study of reasons of FAD loss in La Reunion describes perfectly everything that this type of method can bring to the appraisal in fishing technology. This preventive analysis method assess the potential risks integrates perfectly in the mind of a precaution approach as it would agree to see to apply to the FADs and to their exploitation.Original Abstract: Le developpement des DCP a entraine l'apparition de problemes techniques, issus tant de leur conception, de leur lieu d'implantation que de leur utilisation. Defaillances generees par le manque de fiabilite des composants ou la precarite de reparations aleatoires, celles-ci peuvent s'averer de plus en plus couteuses au fur et a mesure du vieillissement des systemes et cause a terme de leur perte. Pour des domaines aussi divers que l'aerospatiale ou l'amenagement de pont de peche, l'ingenierie dispose d'outils d'analyse fonctionnelle qui, par le biais d'une hierarchisation des valeurs des fonctions de chaque element des systemes etudies, permettent de reduire les incertitudes de la conception. L'application d'une de ces techniques, l'Amdec, analyse des modes de defaillance et de criticite, a l'etude des causes des pertes de DCP a La Reunion illustre parfaitement tout ce que ce type de methode peut apporter a l'expertise en technologie des peches. Cette methode d'analyse preventive qui recense et met en evidence les risques potentiels s'integre parfaitement dans l'esprit d'une approche de precaution telle que celle qu'il conviendrait de voir appliquer aux DCP et a leur exploitation.

Droits : Ifremer
http://archimer.ifremer.fr/doc/00042/15289/12675.pdf
http://archimer.ifremer.fr/doc/00042/15289/

Éditeur(s) : HAL CCSD
Résumé : Among erosion processes, river incision is classicaly described as a key process controlling erosion of landscapes. Incision efficiency is mainly influenced by climate and erodibility. This latter is not only dependent on the nature of the bedrock, but also on its past deformation, which affects its rheological effective properties, such as fracture density. The main objectives of this thesis are: (1) to better constrain the relationship between effective properties and erodibility, and (2) to quantify the influence of erodibility and erosion on both the temporal and spatial building or decay of the topography. Several numerical tools are developed. A 1D formalism of landscape evolution is introduced, including river incision with stochastic distribution of water discharge and hillslope landsliding. A new remeshing algorithm called Surface Lagrangian Remeshing (SLR) is developed as a complement to remeshing algorithms dealing with internal elements. It allows one to take into account long-term erosion into 2D Lagrangian numerical codes based on triangular finite elements. Then the potentiality of measuring erodibility in-situ using a Schmidt hammer (R) is assessed for the active orogen of Taiwan, the diagenetic Annot sandstones and St Clement fault zone. Results suggest a strong control of R by effective properties. A linear model based on effective medium theory is applied to a fault zone with an unmacthed resolution (750 measures, 25 measures per square meter). The model successfully correlates R to fracture density. These results demonstrate that effective elasticity as well as erodibility are sensitive to the density and type of fractures. Finally I focus on the erosional and rheological conditions that allows reproducing post-orogenic evolution of mountain belts. A model coupling surface erosion and regional isostatic uplift is consistent with observations. The topographic decay and decrease of the ratio of surface elevation over crustal root thickness is at first order controlled by the initial geometry of the mountain belt and erosion efficiency. This new model highlights the control ofclimate and erodibility on the topographic decay and of lithospheric rheology on the perseverance of crustal roots.
Parmi les processus d'érosion, l'incision des rivières est classiquement décrit comme un processus clé contrôlant l'érosion des paysages. L'efficacité de l'incision est principalement influencée par le climat et par l'érodabilité. Ce dernier paramètre ne dépend pas seulement de la nature du substratum rocheux, mais aussi de sa déformation passée qui affecte ses propriétés rhéologiques équivalentes. Les principaux objectifs de cette thèse sont: (1) de mieux contraindre les relations entre propriétés équivalentes et érodabilité, et (2) de quantifier l'influence de l'érosion et de l'érodabilité sur la formation ou la décadence, spatiale et temporelle, de la topographie. Plusieurs outils numériques sont développés. Un formalisme 1D d'évolution des paysages est proposé, prenant en compte simultanément l'incision des rivières avec une distribution stochastique des débits en eau et l'érosion des versants par glissements de terrain. Un nouvel algorithme de remaillage appelé Surface Lagrangian Remeshing (SLR) est développé. Il permet de prendre en compte l'érosion à long terme dans les codes numériques 2D Lagrangiens basés sur des éléments finis triangulaires. Ensuite, la possibilité de mesurer in-situ l'érodabilité avec un marteau de Schmidt (R) est évaluée pour: l'orogène actif de Taiwan, les grès diagénétiques d'Annot et la zone de faille de St Clément. Les résultats suggèrent un fort contrôle de R par les propriétés équivalentes des roches testées. Un modèle linéaire, basé sur la théorie des milieux équivalents, est appliqué à une zone de faille avec une résolution inégalée (750 mesures, 25 mesures par mètre carré). Le modèle permet de corréler avec succès la densité de fracture et R. Ces résultats démontrent empiriquement que l'élasticité équivalente ainsi que l'érodabilité sont sensibles à la densité et à la nature des fractures. Enfin j'étudie les conditions d'érosion et de rhéologie qui permettent de reproduire l'évolution des chaînes de montagnes post-orogéniques. Un modèle couplant érosion en surface et soulèvement isostatique régional est compatible avec les observations. Les taux de décroissance topographique et de diminution du rapport de l'élévation de surface sur l'épaisseur de racine crustale sont contrôlés au premier ordre par la géométrie initiale de la chaîne de montagne et par l'efficacité de l'érosion. Ce nouveau modèle met en évidence le contrôle du climat et de l'érodabilité sur la décroissance topographique et de la rhéologie lithosphérique sur la persévérance des racines crustales.
https://tel.archives-ouvertes.fr/tel-00602341

tel-00602341
https://tel.archives-ouvertes.fr/tel-00602341
https://tel.archives-ouvertes.fr/tel-00602341/document
https://tel.archives-ouvertes.fr/tel-00602341/file/thesephilippesteer.pdf

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Retreatment with pegylated interferon (peg-IFN) and ribavirin (RBV) results in poor sustained virological response (SVR) rates in human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients. There are limited data regarding the use of telaprevir plus peg-IFN/RBV in this population. HIV type 1-infected patients who previously failed ≥12 weeks of peg-IFN/RBV for HCV genotype 1 coinfection were enrolled in a single-arm, phase 2 trial. Patients with cirrhosis and previous null response were excluded. Authorized antiretrovirals were tenofovir, emtricitabine, efavirenz, atazanavir, and raltegravir. All patients received peg-IFN alfa-2a (180 µg/week) plus RBV (1000-1200 mg/day) for 4 weeks, followed by telaprevir (750 mg or 1125 mg every 8 hours with efavirenz) plus peg-IFN/RBV for 12 weeks and peg-IFN/RBV for 32-56 weeks according to virological response at week 8. The primary endpoint was the SVR rate at 24 weeks after the end of treatment (SVR24). Sixty-nine patients started treatment; SVR24 was achieved in 55 (80% [95% confidence interval, 68%-88%). SVR24 was not influenced by baseline fibrosis stage, IL28B genotype, antiretroviral regimen, HCV subtype, CD4 cell count, previous response to HCV treatment, HCV RNA level, or HCV RNA decline at week 4. HCV treatment was discontinued for adverse events (AEs) in 20% of patients, including cutaneous (4%), psychiatric (4%), hematological (6%), and other AEs (6%). Peg-IFN or RBV dose reduction was required in 23% and 43% of patients, respectively. Seventy percent of patients required erythropoietin, blood transfusions, or RBV dose reduction for anemia. Two patients died during the study. No HIV breakthrough was observed. Despite a high discontinuation rate related to toxicity, a substantial proportion of treatment-experienced HIV-coinfected patients achieved SVR24 with a telaprevir-based regimen. Clinical Trials Registration. NCT01332955.
ISSN: 1058-4838

hal-01118447
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118447
PUBMED : 25139963
DOI : 10.1093/cid/ciu659

Éditeur(s) : HAL CCSD Elsevier
Résumé : The dense hydrous magnesium silicate called the D phase is the most likely candidate to recycle hydrogen into the lower mantle in subduction zones. As seismology represents the preferred method to detect this mineral in subduction zones, the single crystal elastic tensor has been calculated using first principle methods. A triple cell (View the MathML source) was used to account for an ordered ideal composition of the D phase to lower mantle pressures. The elastic tensor of the mineral at ambient conditions is predicted to be C11 = 387.7, C33 = 287.7, C44 = 100.4, C12 = 108.0, C13 = 51.1, C14 = − 14.6 in GPa with bulk modulus at zero pressure Ko = 163 GPa and a statistical error of about 4.0 GPa for all constants. The pressure derivatives of the elastic constants have been determined to pressure of 80 GPa. Our tensor correctly predicts the published experimental measurements of linear compressibility along the a- and c-axes, the logarithmic pressure derivative of the c/a axial ratio and bulk modulus at zero pressure. It contradicts the experimentally measured elastic tensor reported by (Liu, L.-G., Okamoto, K., Yang, Y.-J., Chen, C.-C., Lin, C.-C., 2004. Elasticity of single-crystal phase D (a dense hydrous magnesium silicate) by Brillouin spectroscopy. Solid State Commun. 132, 517–520), which fails to reproduce the experimental compressibility data. Using the elastic constants and density predicted to 85 GPa, the seismic anisotropy of P- and S-waves has been calculated as a function of pressure. The single crystal has high P-wave velocities and shear wave splitting in the basal plane below 20 GPa. At high pressures, the maximum P-wave velocities have threefold symmetry normal to a-axes in the basal plane, whereas the maximum shear wave splitting is parallel to a-axes with twofold symmetry. The D phase has high Vp and Vs anisotropy at ambient pressure, 17.6% for Vp and 19.9% for Vs. The Vp anisotropy decreases with increasing pressure to about 30 GPa, while it remains constant at 8% from 30 to 85 GPa. The Vs anisotropy decreases to 17% at 20 GPa and then increases to 22% at 85 GPa. The isotropic velocity ratios of S to P (Rs/p), bulk sound to S (Rphi/s) and density to S (Rρ/s) are calculated as a function of pressure. The Rs/p shows very little variation with pressure with low value of 0.6, whereas both Rphi/s and Rρ/s increase with pressure to peak values of 2.8 and 2.0 respectively at about 60 GPa. The presence of the D phase in subducted horizontal ‘stagnant' plates in the circum Pacific could contribute to a number of seismic observations, such as the observed velocity heterogeneity at depths between 500 and 1000 km and the fast S-waves travelling horizontally with horizontal polarization in this depth range. Further the lower density of the D phase compared with anhydrous minerals could influence buoyancy of the hydrated ‘stagnant' slabs. The transformation of the D phase to perovskite plus ferripericlase during thermal annealing may be responsible for horizontal slab seismogenesis.
ISSN: 0012-821X

hal-00406379
https://hal.archives-ouvertes.fr/hal-00406379
DOI : 10.1016/j.epsl.2007.04.053

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Networks of localized conjugate compactive shear bands with large dihedral angles (corresponding to so-called shear-enhanced compaction bands) were generated in 3-layer plane strain finite-difference models. The central layer has elastic–plastic properties with a small positive internal friction coefficient, negative dilatancy factor, and the hardening modulus reducing during the deformation. The two other layers are elastic. The spatial organization of the networks in the central layer, resulting from the elastic–plastic instability of the 3-layer system, was shown to be dependent on the contrast of the elastic stiffness of the layers and on the friction between them. When the stiffness E of the elastic layers and/or the friction are small, the networks are rather symmetric (the bands of both orientation families are distributed homogeneously within the layer). An increase in E at high friction, results in the clustering of the bands of one orientation along a layer segment which is followed by another segment filled with the bands of the other orientation. Different network types are characterized by different band spacing which is smaller in the clustered networks. The intensity of inelastic deformation and hence of porosity reduction within the bands are also smaller in this case. The obtained band networks are very similar to those in nature where the same variability of the network organization is observed. Available geological and mechanical data confirm the conclusions from the modeling about the origin of this variability.
ISSN: 0040-1951

hal-01116201
https://hal.archives-ouvertes.fr/hal-01116201
DOI : 10.1016/j.tecto.2014.01.021

Éditeur(s) : HAL CCSD
Résumé : The evolution of mountain belt piedmont is controlled by interactions between tectonics, erosion and sedimentation. To study coupling between these processes, we analyze morphometric data collected in the eastern Tian Shan piedmont (NW China) and develop a new analogue modelling technique. The modeling approach uses an experimental set-up and analog material specifically designed to study simultaneously tectonic structures (faults, folds), detailed morphology (drainage basins, channels, alluvial fans, etc.) and stratified sedimentation. Measurement techniques based on laser interferometry and image correlation are also developed to quantify the topographic and kinematic evolution of models.
Our experiments allow a new approach for the study of piedmont morphotectonic evolution. Our results indicate that tectonics mainly controls this evolution. The propagation of deformation and the formation of relief both significantly influence the development of drainage networks, the evolution of drainage basins and the formation of morphotectonic markers. Particularly, a study of alluvial fans and watershed metrics suggests that there is a dynamical equilibrium between uplift, erosion and morphology. In addition, our results show that terrace nucleation is controlled by thrust activity and hydrography adjustments. Folding of terraces responds to a homothetic deformation pattern.
This new methodology brings promising perspectives in the fields of geomorphology, seismotectonics and sedimentology.
L'évolution d'un piémont de chaîne de montagnes est contrôlée par les interactions entre la tectonique, l'érosion et la sédimentation. Pour étudier ces processus, nous avons analysé des données morphométriques issues des piémonts orientaux du Tian Shan (NW Chine) et développé un nouveau type de modélisation analogique. Cette approche utilise un dispositif et un matériau expérimental spécialement conçus pour modéliser simultanément des structures tectoniques (failles, plis), une morphologie détaillée (bassins versants, rivières, cônes alluviaux, etc.) et une sédimentation stratifiée. Des techniques de mesure optique ont été également mises en oeuvre afin de quantifier l'évolution topographique et cinématique des modèles.
Les expériences réalisées offrent une opportunité inédite d'étudier l'évolution morphotectonique d'un piémont. Nos résultats montrent que la tectonique exerce un contrôle de premier ordre sur cette évolution. La propagation de la déformation et la formation des reliefs influencent en effet significativement le développement du réseau de drainage, l'évolution des bassins versants et la formation des marqueurs morphotectoniques. En particulier, l'analyse de la morphométrie des cônes alluviaux et de leurs bassins versants suggère qu'un équilibre dynamique s'installe entre la surrection, l'érosion et la morphologie. Nos résultats montrent également que l'apparition des terrasses est guidée par l'activité des chevauchements et les adaptations de l'hydrographie. Leur modèle de plissement répond à une déformation homothétique.
Cette nouvelle approche ouvre des perspectives d'étude prometteuses en géomorphologie, sismotectonique et stratigraphie.
https://tel.archives-ouvertes.fr/tel-00339145

tel-00339145
https://tel.archives-ouvertes.fr/tel-00339145
https://tel.archives-ouvertes.fr/tel-00339145v2/document
https://tel.archives-ouvertes.fr/tel-00339145/file/These_Graveleau08.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
The SOX8 and SOX9 transcription factors are involved in, among others, sex differentiation, male gonad development and adult maintenance of spermatogenesis. Sox8(-/-) mice lacking Sox9 in Sertoli cells fail to form testis cords and cannot establish spermatogenesis. Although genetic and histological data show an important role for these transcription factors in regulating spermatogenesis, it is not clear which genes depend upon them at a genome-wide level. To identify transcripts that respond to the absence of Sox8 in all cells and Sox9 in Sertoli cells we measured mRNA concentrations in testicular samples from mice at 0, 6 and 18 days post-partum. In total, 621 and 629 transcripts were found at decreased or increased levels, respectively, at different time points in the mutant as compared to the control samples. These mRNAs were categorized as preferentially expressed in Sertoli cells or germ cells using data obtained with male and female gonad samples and enriched testicular cell populations. Five candidate genes were validated at the protein level. Furthermore, we identified putative direct SOX8 and SOX9 target genes by integrating predicted SOX-binding sites present in potential regulatory regions upstream of the transcription start site. Finally, we used protein network data to gain insight into the effects on regulatory interactions that occur when Sox8 and Sox9 are absent in developing Sertoli cells. The integration of testicular samples with enriched Sertoli cells, germ cells and female gonads enabled us to broadly distinguish transcripts directly affected in Sertoli cells from others that respond to secondary events in testicular cell types. Thus, combined RNA profiling signals, motif predictions and network data identified putative SOX8/SOX9 target genes in Sertoli cells and yielded insight into regulatory interactions that depend upon these transcription factors. In addition, our results will facilitate the interpretation of genome-wide in vivo SOX8 and SOX9 DNA binding data.
Andrology

hal-00877013
https://hal.archives-ouvertes.fr/hal-00877013
DOI : 10.1111/j.2047-2927.2012.00049.x
PUBMED : 23315995

Résumé : La recevabilité est le cœur de la procédure judiciaire. Elle permet d’étudier la pénalisation de la vie internationale. Elle semble pouvoir rendre compte de la réponse judiciaire à la rancœur internationale au regard des grands faits criminels ; quel qu’en fut le territoire de commission.Cette thèse porte sur la notion de recevabilité devant la Cour pénale internationale. Avec la création de la CPI, la justice pénale internationale prend une dimension nouvelle. La pratique de la Cour est encore récente. L’étude est le prétexte pour examiner le fonctionnement de la Cour pénale internationale. Les Etats ont tenté de limiter la capacité de recevoir de la Cour. Ils l’ont ainsi fondée sur le principe de la complémentarité. Elle supplée l’inaction ou l’action défaillante des Etats, qui ont le devoir de poursuivre les auteurs de crimes internationaux. L’article 17 du Statut de Rome énonce les exceptions permettant de déclarer une affaire recevable devant la CPI. Ainsi, la recevabilité d’une affaire ayant fait l’objet d’une enquête ne sera retenue que s’il est prouvé que les Etats n’ont pas l’intention de mener véritablement à bien les poursuites. Et, que par ailleurs, le seuil de gravité de l’affaire est atteint. Le caractère universel de la compétence de la CPI est battu en brèche par les conditions de recevabilité. On analyse la recevabilité comme une condition de compétence à juste titre, car c’est bien le manquement de l’Etat à assurer l’effectivité des poursuites qui justifie que l’affaire soit déclarée, par la Cour elle-même, recevable. Les conditions requises pour que la Cour puisse agir, force est de constater l’implication du système de recevabilité tant sur l’organisation de la Cour que sur ses rapports avec les Etats. Celles-ci ne sont pas négligeables. De fait, le système de recevabilité est amené à évoluer. Il se caractérise par sa capacité à influencer le droit interne. Ainsi, la décision de recevoir doit amener les Etats à adapter leur droit interne. La viabilité de la Cour, à long terme, dépend du maintien d’une synergie de coopération avec les juridictions nationales, des États parties et d'autres Etats. Le système de recevabilité tend à mettre en évidence des indicateurs émergents dans la pratique de la Cour pénale internationale. C’est notamment le réalignement frappant des rôles des acteurs internationaux et la relation nouvelle qui s’instaure entre les Etats et la Cour. Le système de recevabilité de la Cour tend à éroder le principe de la souveraineté de l'Etat, sans être elle-même balayée par l'opposition catégorique des Etats souverains.
Admissibility is the heart of the judicial process. It studies the criminalization of international life. It seems to account for the judicial response to the international resentment against the great criminal acts, whatever was the territory of commission.This thesis deals with the notion of admissibility before the ICC. With the creation of the ICC, International Criminal Justice is a new dimension. The practice of the Court is still new. The study is an excuse to investigate the operation of the ICC. States have tried to limit the ability to receive from the Court. They did so based on the principle of complementarity. It compensates the action or inaction of failing states, which have a duty to prosecute international crimes. Article 17 RS sets out exceptions to declare a case admissible before the ICC. Thus, the admissibility of a case which is the subject of an investigation will be accepted only, if it is shown that States did not intend genuinely to carry out prosecutions. And that furthermore, the threshold of gravity of a case is reached. The universal nature of the jurisdiction of the ICC is undermined by the conditions of admissibility. Analyzing the admissibility of competence as a condition rightly, for it is the failure of the state to ensure effective prosecution to justify that the case will be declared by the Court itself, admissible. The requirements for the Court to act, it is clear involvement of the system of admissibility as on the organization of the Court that its relationship with the United States. These are not insignificant. In fact, the system will evolve admissibility. It is characterized by its ability to influence the law. Thus, the decision to receive should encourage States to adapt their domestic law. The viability of the Court, in the long run depends on maintaining a synergy of cooperation with national courts of States Parties and other States. The system of admissibility tends to highlight indicators emerging in the practice of the International Criminal Court. This is especially striking realignment of the roles of international actors and the new relationship established between the States and the Court. The system of admissibility of the Court tends to erode the principle of state sovereignty, without itself being swept by the opposition of sovereign states.

http://www.theses.fr/2011AGUY0468

Éditeur(s) : HAL CCSD CSIRO Publishing
Résumé :  
Leaf traits of tropical tree species display an important inter-specific diversity, as detected for instance in the large range of values of leaf mass : area ratio (LMA). They also demonstrate a large irradiance-elicited plasticity, but there is still debate whether this plasticity differs among species. To address this question, leaf traits were recorded on saplings from 12 rainforest tree species in French Guiana, grown under approximately 5, 10 and 20% relative irradiance. Fifteen structural and physiological leaf traits related to photosynthesis were measured. The irradiance-elicited plasticity was quantified using a relative distance plasticity index. A large inter-specific diversity was detected for all leaf traits. A principal component analysis opposed species with a large mass-based photosynthesis, respiration, N content and photosynthetic nitrogen use efficiency, to species with a large leaf mass : area ratio, LMA. The two pioneer species used in this study displayed the largest photosynthetic capacity (and lowest LMA) and ranked at one end of the species continuum. Relative irradiance affected almost all traits with the exception of mass-based photosynthesis.Aweak interaction was found between species and relative irradiance and the species ranking was maintained among relative irradiance treatments for the majority of the traits. A principal component analysis of the values of relative-distance plasticity index failed to reveal any consistent patterns of traits or species.Weconcluded that irradiance-elicited plasticity of leaf traits was similar among species irrespective ofLMA and successional status, despite the occurrence of a large inter-specific diversity for the investigated traits
ISSN: 1445-4408

hal-01032129
https://hal.archives-ouvertes.fr/hal-01032129
DOI : 10.1071/FP09119

Éditeur(s) : HAL CCSD
Résumé : The mantle deformation processes that control the thinning and break-up of continental lithosphere remain poorly understood. Our knowledge is restricted to either lithospheric scale thermo-mechanical models --that use experimentally derived flow laws--, geophysical imaging and/or rare xenoliths from active continental rifts, such as the East African Rift System. The originality of this work relies on the study of the two largest outcrops of diamond facies subcontinental lithospheric mantle in the world: the Beni Bousera and Ronda peridotite massifs in N Morocco and S Spain, respectively. The structures and petrologic and metamorphic zoning preserved in these massifs --implying a polybaric and polythermal evolution-- provides a unique opportunity to investigate the thermo-mechanical evolution of thick subcontinental lithospheric mantle in extensional settings. In this thesis we studied the deformation mechanisms in both peridotites and pyroxenites to constrain the modes of exhumation of subcontinental lithospheric mantle from garnet-, to spinel-, and finally, to plagioclase lherzolite facies conditions. We combined field mapping of tectonometamorphic domains and structural mapping of ductile structures, microstructural analysis, crystal preferred orientations (CPO) measurements and conventional thermobarometric calculations and thermodynamic modeling (Perple_X) to unravel the pressure and temperature conditions of deformation. We showed that exhumation from garnet- to spinel lherzolite facies conditions was accommodated by fast shearing --in thermal disequilibrium--along a lithospheric scale transtensional shear zone. In this context, the petrological zoning and the large temperature gradient (ca. 100ºC/km) preserved in the Beni Bousera massif represent the mechanical juxtaposition of progressively deeper and hotter lithospheric levels at depths of ca. 60 km in the latest Oligocene (ca. 25 Ma). Final exhumation from spinel- to plagioclase facies lherzolite and emplacement into the crust is best recorded in the Ronda massif where it occurred by inversion and lithospheric scale folding of the highly attenuated continental lithosphere in a back-arc region, probably in relation with southward slab rollback and subsequent collision with the palaeo-Maghrebien passive margin in the early Miocene (21-23 Ma).
Les processus de déformation contrôlant l'amincissement de la lithosphère continentale sont encore mal contraints. Nos connaissances sont principalement basées sur la modélisation thermomécanique d'extension à l'échelle de la lithosphère--utilisant des lois rhéologiques derivées expérimentalement, l'imagerie géophysique et l'analyse de xénolithes provenant de rift continentaux actifs à ce jour, tels que le Rift Est-Africain. L'originalité de ce travail reside dans l'étude des deux plus grands massifs de péridotites sous-continentales ayant enregistrées des conditions primaires du facies à diamant: les massifs de Beni Bousera au nord du Maroc et de Ronda au sud de l'Espagne, respectivement. Les structures et la zonation petrologique et métamorphique --impliquant une évolution polybarique et polythermique-- préservéees dans ces massifs offrent une opportunité unique pour étudier l'évolution thermo-mécanique du manteau sous-continental dans un contexte extensif. Dans ce travail, nous avons étudié les mécanismes de déformation des péridotites et des pyroxénites afin de contraindre les modes d'exhumation du manteau lithosphérique sous-continental, depuis des conditions du facies des lherzolites à grenat, jusqu'au facies à spinelle et enfin à plagioclase. Nous avons combiné la cartographie des faciès tectono-métamorphiques et des structures ductiles de déformation, l'analyse des microstructures, la mesure d'orientations préférentielles de réseau (OPR), et la géothermobarométrie conventionelle couplée à la modélisation thermodynamique (PerpleX) afin de contraindre les conditions de pression et température de la déformation. Nous avons montré que l'exhumation précoce du facies à grenat au facies à spinelle était accomodée par une faille transtensive affectant le manteau lithosphérique. Dans ce contexte, la zonation tectono-métamorphique et le gradient thermique important (ca. 100ºC/km) préservés à Beni Bousera résultent de la juxtaposition mécanique de domaines lithosphériques initialement équilibrés à différentes pressions et températures, fossilisée à une profondeur de ca. 60 km durant l'Oligocène supérieur (ca. 25 Ma). L'exhumation finale du facies de lherzolite à spinelle au facies à plagioclase et l'emplacement final dans la croûte, mieux enregistrés dans Ronda, se sont produits par inversion et plissement de la section lithosphérique fortement amincie dans un contexte arrière-arc, probablement lors du retrait vers le sud de la lithosphère subduite et la collision de l'arc avec les paléo-marges maghrébines au Miocène inférieur (21-23 Ma).
https://tel.archives-ouvertes.fr/tel-00767700

tel-00767700
https://tel.archives-ouvertes.fr/tel-00767700
https://tel.archives-ouvertes.fr/tel-00767700/document
https://tel.archives-ouvertes.fr/tel-00767700/file/THESE_Frets.pdf

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Due to shallow penetration of millimeter waves (MMW) and convection in liquid medium surrounding cells, the problem of accurate assessment of local MMW heating in in vitro experiments remains unsolved. Conventional dosimetric MMW techniques, such as infrared imaging or fiber optic (FO) sensors, face several inherent limits. Here we propose a methodology for accurate local temperature measurement and subsequent specific absorption rate (SAR) retrieval using microscale thermocouples (TC). SAR was retrieved by fitting the measured initial temperature rise to the numerical solution of an equivalent thermal model. It was found that the accuracy of temperature measurement depends on thermosensor size, that is, the smaller TC, the more accurate the temperature measurement. SAR determined using TC with lead diameters of 25 and 75m demonstrated 98.5% and 80.4% match with computed SAR, respectively. However, both TC provided the same temperature rises in long run (>10min). FO probe failed to measure adequately local heating both for short and long exposures due to the relatively large size of the probe sensor (400m) and time constant (0.6s). Calculated SAR in the cell monolayer was almost two times lower than that in the surrounding liquid. It was shown that the impact of the cell monolayer on heating due to its small thickness (5 to 10m) can be considered as negligible. Moreover, we demonstrated the possibility of accurate measurement of MMW-induced thermal pulses (up to 10 degrees C) using 25m TC. Bioelectromagnetics. 38:11-21, 2017. (c) 2016 Wiley Periodicals, Inc.
ISSN: 0197-8462

hal-01436768
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01436768
DOI : 10.1002/bem.21999
PUBMED : 27571392

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : The Great Glen Fault (GGF) is a major lithospheric strike-slip fault system that cuts across the Caledonian orogenic belt of Scotland. It separates the Northern Highlands terrane from the Grampian terrane. Movement history along the fault extends at least into the Early Palaeozoic. The low-temperature history of the Scottish Highlands covers a significant period from the Late Palaeozoic to the Present, but the magnitude of vertical movements that affected the GGF area during that time is still a matter of debate. Fission track analysis on detailed vertical profiles in the Ballachulish and Strontian complexes, as well as on a profile oriented northeastwards across the GGF, reveals distributed differential vertical movements along the fault during the Late Palaeozoic. The Mesozoic denudation is estimated at a maximum of 2 km before a more recent widespread exhumation event that started at around 40–25 Ma, leading to 1.6 to 2 km of erosion. La Great Glen Fault (GGF) est un système décrochant lithosphérique majeur qui traverse la chaîne calédonienne d'Écosse. Il sépare les domaines des Northern Highlands et de Grampian. L'histoire tectonique de ce système remonte au moins au Paléozoïque inférieur. L'histoire de la dénudation des Highlands d'Écosse s'étend du Paléozoïque supérieur jusqu'au Présent, mais l'ampleur des mouvements verticaux ayant affecté la zone autour du système de la GGF pendant cette période est toujours sujette à débat. Les analyses traces de fission réalisées sur des profils verticaux dans les complexes granitiques du Ballachulish et de Strontian, ainsi que sur un profil plus au nord-est à travers la GGF, mettent en évidence des mouvements différentiels distribués de part et d'autre de la faille au Paléozoïque supérieur. La dénudation mésozoïque est estimée au maximum à 2 km, avant un dernier épisode de surrection généralisée à partir de 40–25 Ma, qui provoque environ 1,6 à 2 km d'érosion.
ISSN: 1631-0713

hal-00406583
https://hal.archives-ouvertes.fr/hal-00406583
DOI : 10.1016/j.crte.2006.12.005

Éditeur(s) : HAL CCSD American Public Health Association
Résumé : International audience
BACKGROUND: It is well established that high adherence to HIV-infected patients on highly active antiretroviral treatment (HAART) is a major determinant of virological and immunologic success. Furthermore, psychosocial research has identified a wide range of adherence factors including patients' subjective beliefs about the effectiveness of HAART. Current statistical approaches, mainly based on the separate identification either of factors associated with treatment effectiveness or of those associated with adherence, fail to properly explore the true relationship between adherence and treatment effectiveness. Adherence behavior may be influenced not only by perceived benefits-which are usually the focus of related studies-but also by objective treatment benefits reflected in biological outcomes. METHODS: Our objective was to assess the bidirectional relationship between adherence and response to treatment among patients enrolled in the ANRS CO8 APROCO-COPILOTE study. We compared a conventional statistical approach based on the separate estimations of an adherence and an effectiveness equation to an econometric approach using a 2-equation simultaneous system based on the same 2 equations. RESULTS: Our results highlight a reciprocal relationship between adherence and treatment effectiveness. After controlling for endogeneity, adherence was positively associated with treatment effectiveness. Furthermore, CD4 count gain after baseline was found to have a positive significant effect on adherence at each observation period. This immunologic parameter was not significant when the adherence equation was estimated separately. In the 2-equation model, the covariances between disturbances of both equations were found to be significant, thus confirming the statistical appropriacy of studying adherence and treatment effectiveness jointly. CONCLUSIONS: Our results, which suggest that positive biological results arising as a result of high adherence levels, in turn reinforce continued adherence and strengthen the argument that patients who do not experience rapid improvement in their immunologic and clinical statuses after HAART initiation should be prioritized when developing adherence support interventions. Furthermore, they invalidate the hypothesis that HAART leads to "false reassurance" among HIV-infected patients.
ISSN: 0025-7079

hal-00875196
https://hal.archives-ouvertes.fr/hal-00875196
DOI : 10.1097/MLR.0b013e3182422f61
PUBMED : 22362167

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aryl hydrocarbon receptor-dependent genomic effects of environmental polycyclic aromatic hydrocarbons (PAHs) have been shown to be modulated by non-genomic protein kinase C (PKC)-related pathways. The present study was designed to determine whether PKC activation may also impair estrogenic genomic response triggered by PAHs. Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed. BZA/PMA cotreatment however failed to alter BZA-mediated increase of activity of a luciferase gene reporter construct driven by an estrogen response element, thus discarding any global effect of PMA toward BZA-triggered estrogen receptor activation. Various chemicals inhibiting PKCs or extracellular signal-regulated kinase (ERK) as well as the knock-down of PKCδ expression counteracted the PMA-mediated increase of pS2 mRNA up-regulation triggered by BZA, demonstrating that it was dependent on PKCs, including PKCδ isoform, and ERKs. This non-genomic modulation of estrogenic effects of PAHs by PKC activation may have to be considered when considering the deleterious effects of these environmental contaminants towards the endocrine system.
ISSN: 0887-2333

inserm-00872862
http://www.hal.inserm.fr/inserm-00872862
DOI : 10.1016/j.tiv.2012.05.006
PUBMED : 22643241