Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Masson
Résumé : International audience
In French Guiana, the age-standardized incidence rate of cervical cancer is four times higher than in France and the mortality rate 5.5 times higher. A survival study revealed that stage at diagnosis was the main factor influencing the prognosis, showing that early detection is crucial to increase cervical cancer survival. The present study aimed at evaluating the cervical cancer screening rate between 2006 and 2011 by age and for 3-years period in French Guiana. All pap smears realised in French Guiana were analysed in two laboratories allowing exhaustive review of screening data. The screening rate was estimated at about 54% from 2006 to 2011, with a statistical difference between coastal and rural area (56.3% versus 18.7%).Although the methodological difference did not allow comparisons with mainland France, these results could be used to evaluate the impact of organised cervical cancer screening by the French Guiana Association for Organized Screening of Cancers implemented in French Guiana since 2012.
ISSN: 0037-9085

hal-01260391
https://hal.archives-ouvertes.fr/hal-01260391
https://hal.archives-ouvertes.fr/hal-01260391/document
https://hal.archives-ouvertes.fr/hal-01260391/file/2015%2C%20Douine%20-%20Servical%20cancer.pdf

Éditeur(s) : HAL CCSD European Geosciences Union
Résumé : International audience
The seasonal climate drivers of the carbon cycle in tropical forests remain poorly known, although these forests account for more carbon assimilation and storage than any other terrestrial ecosystem. Based on a unique combination of seasonal pan-tropical data sets from 89 experimental sites (68 include aboveground wood productivity measurements and 35 litter productivity measurements), their associated canopy photosynthetic capacity (enhanced vegetation index, EVI) and climate, we ask how carbon assimilation and aboveground allocation are related to climate seasonality in tropical forests and how they interact in the seasonal carbon cycle. We found that canopy photosynthetic capacity seasonality responds positively to precipitation when rainfall is < 2000 mm yr(-1) (water-limited forests) and to radiation otherwise (light-limited forests). On the other hand, independent of climate limitations, wood productivity and litterfall are driven by seasonal variation in precipitation and evapotranspiration, respectively. Consequently, light-limited forests present an asynchronism between canopy photosynthetic capacity and wood productivity. First-order control by precipitation likely indicates a decrease in tropical forest productivity in a drier climate in water-limited forest, and in current light-limited forest with future rainfall < 2000 mm yr(-1).
ISSN: 1726-4170

hal-01557759
https://hal.univ-lorraine.fr/hal-01557759
https://hal.univ-lorraine.fr/hal-01557759/document
https://hal.univ-lorraine.fr/hal-01557759/file/bg-13-2537-2016.pdf
DOI : 10.5194/bg-13-2537-2016

Éditeur(s) : HAL CCSD Springer
Résumé : International audience
Diabetologia
Stockholm, Sweden

hal-01204766
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01204766
DOI : 10.1007/s00125-015-3687-4

Éditeur(s) : HAL CCSD
Résumé : International audience
Multiple chemicals are emitted in residential accommodation. Aggregate Daily Doses (ADD) (ng/kg-bw/d) were estimated for 32 semivolatile organic compounds (SVOCs) of different chemical families that are frequently detected in French dwellings in both air and settled dust. Daily doses were determined using steady-state models for the population, categorized into 11 age groups covering birth to age 30. Three routes of exposure were taken into account: dust ingestion, inhalation (gaseous and particulate phases) and dermal contact with the gaseous phase of air. Contamination levels were preferentially retrieved from large, nationwide representative datasets. A two-dimensional probabilistic approach was used to assess parametric uncertainty and identify the most influential factors. For children aged 2 to 3 years, ADD estimates spanned orders of magnitude, with median values ranging from 8.7 pg/kg-bw/d for 2,2′,3,4,4′-pentabromodiphenylether (BDE 85) to 1.3 μg/kg-bw/d for di-isobutyl phthalate (DiBP). Inhalation, ingestion and dermal pathway contributed at varying levels, and depending on compound, air was the dominant medium for 28 of the 32 compounds (either by inhalation or dermal contact). Indoor exposure estimate variance was mainly driven by indoor contamination variability, and secondarily by uncertainty in physical and chemical parameters. These findings lend support to the call for cumulative risk assessment of indoor SVOCs. © 2017 Elsevier Ltd
ISSN: 01604120

hal-01616433
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616433
DOI : 10.1016/j.envint.2017.08.024
PUBMED : 28950160

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : National audience
Objectif Analyser les caractéristiques virologiques et les complications des syndromes grippaux chez les diabétiques en période hivernale. Patients et Méthodes Étude conduite dans 6 hôpitaux (Montpellier, Lyon, Cochin, Bichat, Limoges, Rennes) au cours de 3 saisons grippales (2012-2013, 2013-2014 et 2014-2015), sur 1 451 adultes hospitalisés avec syndrome grippal récent (début ≤ 7 jours), associant un signe respiratoire (toux, dys-pnée) et un signe systémique (fièvre, céphalées, malaise, myalgies). Les virus respiratoires étaient recherchés par RT-PCR sur prélèvement naso-pharyngé ou LBA (Centre National de Référence, Lyon). La vaccination anti-grippale, la présence d'un diabète, les comorbidités, les complications en cours d'hospitalisation (insuffisance rénale, cardiaque, respiratoire, pneumonie, décès) et la durée moyenne de séjour (DMS) étaient enregistrées. Les facteurs de risque de complications ont été étudiés par régression logistique multivariée ajustée sur âge, sexe, infection grippale, vaccination, diabète et antécédents de pathologies rénale, cardiaque ou respiratoire. Résultats Les hospitalisations ont eu lieu dans des services de maladies respiratoires, médecine interne, MIT et réanimation. Un diabète était présent chez 368 sujets (non traités : 15 %, ADO : 41 %, insuline : 27 %, mixte : 17 %). Les diabétiques étaient plus âgés (71 ± 15 vs 65 ± 20 ans, P < 0,001) et présentaient plus souvent un antécédent de pathologie rénale (18 % vs 8 %, P < 0,00001) ou cardiaque (19 % vs 11 %, P < 0,001). Leur couverture vaccinale était meilleure (60 % vs 46 %). Les données virologiques étaient comparables : grippe 38,9 % (76,1 % type A) vs 39,2 % ; (74,1 % type A) ; autres virus respiratoires : 17,0 % vs 19,9 %. La DMS était un peu plus élevée chez les diabétiques (9,1 ± 9 vs 8,9 ± 11, P = 0,015), avec une tendance à un risque de décès plus élevé (6,25 % vs 3,97 %, P 0,07). En analyse multivariée, le diabète était un facteur de risque de complications à type d'insuffisance rénale (OR : 1,66, IC 95 % : 1,10-2,52) mais pas d'insuffisance cardiaque, respiratoire ou de décès. Les complications n'étaient pas modi-fiées par les résultats virologiques. Conclusions Le diabète est un facteur de risque de complications rénales chez les patients hospitalisés avec syndrome grippal
ISSN: 1262-3636

hal-01300779
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01300779
DOI : 10.1016/S1262-3636(16)30020-9

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The current interpretation of the Messinian Salinity Crisis (MSC) involves the deposition of peripheral or marginal evaporites in onshore basins as well as the erosion of the margin and the deposition of thick evaporites in deep basins. The so-called intermediate basins are formed in domains between the onland outcrops and the deep basins. The Balearic Promontory is a bathymetric high located between the deep Algerian and Liguro-Provençal basins and the onland Spanish basin. The SIMBAD project aims to investigate the spatial variability of the MSC-related deposits and to assess the extent of post-MSC reactivation over the Balearic Promontory. We present here the first results of the SIMBAD high-resolution seismic survey (January 2013) which imaged for the first time a thin MSC-related unit widely distributed in small sub-basins over the Balearic Promontory.Borehole analyses have shown that this unit could be correlated with primary gypsum formations linked to the peripheral evaporites. Locally, in the Central Depression between Mallorca and Ibiza islands, a thicker MSC unit is observed whose lowermost transparent part could correspond to a salt layer. Geometrical relationships suggest that the MSC in the Central Depression could postdate the primary gypsum. The occurrence of a halite layer in the Central Depression, at depths of 1000 to 1500 m, favours the hypothesis that the evaporites precipitated passively in closed or partially closed perched sub-basins, possibly as a result of evaporative drawdown at different depths and possibly diachronously, at least with respect to the deep-basin evaporites.
ISSN: 0264-8172

hal-01364255
https://hal.archives-ouvertes.fr/hal-01364255
DOI : 10.1016/j.marpetgeo.2014.09.008

Éditeur(s) : HAL CCSD Taylor & Francis
Résumé : The diamond anvil cell (DAC) is a fundamental device used to explore the properties of materials under extreme pressure and temperature (P/T) conditions. In the past years, simultaneous high P/T DAC experiments using the resistively heated DAC (RH-DAC) techniques have been developed for studying materials properties in a wide P/T range. However, the mechanical instability of metallic gaskets used for sample confinement at high P/T conditions remains a limiting factor for exploiting the accessible P/T range of the RH-DAC. In this study, we present a new gasket configuration that overcomes these limitations. It is based on an amorphous boron-epoxy mixture inserted in a rhenium gasket. We show how these gasket inserts stabilize the sample chamber over a wide P/T range, allowing monitoring sample properties using X-ray diffraction and absorption spectroscopy up to 50GPa and 1620K.
ISSN: 0895-7959

hal-01608425
https://hal.archives-ouvertes.fr/hal-01608425
DOI : 10.1080/08957959.2016.1245297
PRODINRA : 387347

Éditeur(s) : HAL CCSD
Résumé : National audience
Introduction Bien que le nombre de cas de paludisme soit en recul en Guyane des foyers touchant les populations autochtones persistent, particulièrement dans certaines zones isolées et frontalières. Afin d’améliorer les stratégies de contrôledu paludisme dans ces zones, nous avons chercher à mieux connaître les attitudes et pratiques vis à vis du paludisme auprès d’une de ces populations-clés.
17es Journées Nationales d’Infectiologie
Lille, France

inserm-01410981
http://www.hal.inserm.fr/inserm-01410981
http://www.hal.inserm.fr/inserm-01410981/document
http://www.hal.inserm.fr/inserm-01410981/file/2016%2C%20Mosnier%20-%20TROP14.pdf
PUBMED : 27495656

Éditeur(s) : HAL CCSD SAGE Publications (UK and US)
Résumé : International audience
In the literature, the enamelin gene ENAM has been repeatedly designated as a possible candidate for caries susceptibility. Here, we checked whether ENAM variants could increase caries susceptibility. To this aim, we sequenced coding exons and exon-intron boundaries of ENAM in 250 children with a severe caries phenotype and in 149 caries-free patients from 9 French hospital groups. In total, 23 single-nucleotide polymorphisms (SNPs) were found, but none appeared to be responsible for a direct change of ENAM function. Six SNPs had a high minor allele frequency (MAF) and 6 others were identified for the first time. Statistical and evolutionary analyses showed that none of these SNPs was associated with caries susceptibility or caries protection when studied separately and challenged with environmental factors. However, haplotype interaction analysis showed that the presence, in a same variant, of 2 exonic SNPs (rs7671281 and rs3796704; MAF 0.12 and 0.10, respectively), both changing an amino acid in the protein region encoded by exon 10 (p.I648T and p.R763Q, respectively), increased caries susceptibility 2.66-fold independent of the environmental risk factors. These findings support ENAM as a gene candidate for caries susceptibility in the studied population.
ISSN: 0022-0345

hal-01545476
https://hal.archives-ouvertes.fr/hal-01545476
DOI : 10.1177/0022034514522060

Éditeur(s) : HAL CCSD Le Cherche midi CNRS
Résumé : 192 pages
National audience
https://hal.archives-ouvertes.fr/hal-01118878

ISBN : 978-2-7491-4075-9
hal-01118878
https://hal.archives-ouvertes.fr/hal-01118878

Éditeur(s) : HAL CCSD
Résumé : International audience
Systemic Antifungal therapy (SAT) of invasive candidiasis (IC) needs to be started immediately upon clinical suspicion. Controversies exist then about potential harms from antifungal de-escalation (DE).(1) in cases of documented IC, early DE to fluconazole is recommended by US guidelines but discouraged in EU guidelines. in non-documented IC, no data are available to guide SAT DE. These questions are key issues however as the relationship between antifungal use and Candida antifungal resistance has been repeatedly demonstrated.
Intensive Care Medicine Experimental

hal-01334073
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01334073
DOI : 10.1186/2197-425X-3-S1-A5
PUBMED : 27290057

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A dense, local network of 30 geodetic markers covering a 50 × 60 km2 area in the southwestern European Alps (Briançon region) has been temporarily surveyed in 1996, 2006 and 2011 by GPS. The aim is to measure the current deformation in this seismically active area. The study zone is characterized by a majority of extensional and dextral focal mechanisms, along north–south to N160 oriented faults. The combined analysis of the three measurement campaigns over 15 years and up to 16 years of permanent GPS data from the French RENAG network now enables to assess horizontal velocities below 1 mm/year within the local network. The long observation interval and the redundancy of the dense campaign network measurement help to constrain a significant local deformation pattern in the Briançon region, yielding an average E–W extension of 16 ± 11 nanostrain/year. We compare the geodetic deformation field to the seismic deformation rate cumulated over 37 years, and obtain good coherencies both in amplitude and direction. Moreover, the horizontal deformation localized in the Briançon region represents a major part of the Adriatic-European relative plate motion. However, the average uplift of the network in an extensional setting needs the presence of buoyancy forces in addition to plate tectonics.
ISSN: 0264-3707

hal-01119724
https://hal.archives-ouvertes.fr/hal-01119724
DOI : 10.1016/j.jog.2015.02.001

Éditeur(s) : HAL CCSD American Society for Microbiology
Résumé : International audience
A number of men receiving prolonged suppressive HAART still shed HIV in semen. To investigate whether this seminal shedding may be due to poor drug penetration and/or viral production by long-lived cells within male genital tissues, we analyzed semen and reproductive tissues from macaques chronically infected with SIVmac251 submitted to HAART for 4 months, intensified over the last seven weeks with an integrase inhibitor. We showed that a subset of treated animals continued shedding SIV in semen despite efficient HAART. This shedding was not associated with low antiretroviral drug concentrations in semen, or in testis, epididymis, seminal vesicles and prostate. HAART had no significant impact on SIV RNA in the urethra, whereas it drastically reduced SIV RNA levels in the prostate and vas deferens, and to a lesser extent in the epididymis and seminal vesicle. The only detectable SIV RNA positive cells within the male genital tract after HAART were urethral macrophages. SIV DNA levels in genital tissues were not decreased by HAART, suggesting the presence throughout the male genital tract of non-productively infected cells. In conclusion, our results demonstrate that 4 months of HAART induced variable and limited control of viral infection in the male reproductive organs, particularly the urethra, and suggest that infected long-lived cells in the male genital tract may be involved in persistent seminal shedding during HAART. These results pave the way for further investigations of male genital organs infection in long term treated infected individuals. A substantial subset of men receiving prolonged suppressive HAART in the blood still harbor HIV in semen, and cases of sexual transmission have been reported. To understand the origin of this persistence, we analyzed the semen and male reproductive tissues from SIV-infected macaques treated by HAART. We demonstrated that persistent seminal shedding was not linked to poor drug penetration in semen or semen-producing prostate, seminal vesicle, epididymis and testis. We revealed that HAART decreased SIV RNA to various extents in all male genital organs, with the exception of the urethra, in which SIV RNA+ macrophages were observed despite HAART. Importantly also, HAART did not impact SIV DNA levels in the male genital organs. These results suggest that infection of male genital organs, and particularly the urethra, could be involved in the release of virus in semen during HAART.
ISSN: 0022-538X

hal-01139816
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01139816
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01139816/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01139816/file/Detection%20of%20SIV%20in%20Semen%2C%20Urethra%2C%20and%20Male%20Reproductive%20Organs%20during%20Efficient%20Highly%20Active%20Antiretroviral%20Therapy.pdf
PUBMEDCENTRAL : PMC4442442

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Souttoufide belt is situated between the High-Atlas in the north, the Mauritanides in the south and the West African Craton as well as the Tindouf basin in the east. Thus, this belt is a part of the West African fold belt system which surrounds the West African Craton. Outcrops occur only in three areas, while the rest of the Souttoufide belt is covered by Meso- to Cenozoic sediments. These areas are, from the south to the north, the Adrar Souttouf Massif, the Smara Zemmour area, and the western part of the Anti-Atlas. Because of the continuing processing and numerous publications, the Anti-Atlas cannot be dealt with in detail. Fundamental geological work in both of the other areas was mainly done during the second third of the 20th century, followed by several decades of inactivity. Numerous studies were done in the Adrar Souttouf massif during the last decade, while the Smara-Zemmour area still remains poorly investigated. Most of them were focused on geochronological analyses and geochemistry. Accordingly, the obtained data led to a new interpretation. The Adrar Souttouf is interpreted as a Pan-African belt exhibiting a Neoproterozoic island arc reworked by the Variscan collision between the North American Craton (NAC) and the West African Craton (WAC). The Smara-Zemmour area is considered as the external part of this Variscan belt thrusted onto the Palaeozoic Tindouf basin. The western Anti-Atlas as considered as a Pan-African active margin reworked during the Variscan orogen. Together, these three areas, lead to the hypothesis of a Late Pan-African belt capped by the Early and Middle Palaeozoic covers and then affected by the Middle Carboniferous tectonic event (330 Ma) related to the Pangaean assembly. Correlations with adjacent belts (Mauritanides and Anti-Atlas) are considered.
ISSN: 0899-5362

hal-01382815
https://hal.archives-ouvertes.fr/hal-01382815
DOI : 10.1016/j.jafrearsci.2015.04.016

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ISSN: 1354-1013

hal-01080954
https://hal-agroparistech.archives-ouvertes.fr/hal-01080954
DOI : 10.1111/j.1365-2486.2007.01439.x

Éditeur(s) : HAL CCSD
Résumé : International audience
South-east Iran is the site of a rare case of young transition between subduction and collision. We synthesized recent results in geodesy, tectonics, seismology and magnetism to understand the structure and kinematics of the Zagros-Makran transition. Surface observations (tectonics, magnetism and geodesy) draw a transpressive discontinuity consisting of several faults striking obliquely to the convergent plate motion, whereas deeper observations (seismology) support a smooth transition across the fault system. No lithospheric transform fault has been created, even though the transition already behaves like a major boundary in terms of tectonic style, seismic structure, lithology and magnetism. The Zendan-Minab-Palami fault system consists of several faults that accommodate a transpressive tectonic regime. It is the surface expression of a southward propagation of the N-trending right-lateral strike-slip fault system of Jiroft-Sabzevaran. Within each system the numerous faults will coalesce into a single, lithospheric, wrench fault.
ISSN: 0375-6440

hal-00356532
https://hal.archives-ouvertes.fr/hal-00356532
https://hal.archives-ouvertes.fr/hal-00356532/document
https://hal.archives-ouvertes.fr/hal-00356532/file/Regard_MinabSynthese_revised_AvecFigs.pdf
DOI : 10.1144/SP330.4

Éditeur(s) : HAL CCSD IOP Publishing
Résumé : The Bureau International des Poids et Mesures (BIPM), Sevres, France, hosted the 7th International Comparison of Absolute Gravimeters (ICAG) and the associated Relative Gravity Campaign (RGC) from August to September 2005.;ICAG 2005 was prepared and performed as a metrological pilot study, which aimed:;(1) To determine the gravity comparison reference values;;(2) To determine the offsets of the absolute gravimeters; and;(3) As a pilot study to accumulate experience for the CIPM Key Comparisons.;This document presents a complete and extensive review of the technical protocol and data processing procedures. The 1st ICAG-RGC comparison was held at the BIPM in 1980-1981 and since then meetings have been organized every 4 years.;In this paper, we present an overview of how the meeting was organized, the conditions of BIPM gravimetric sites, technical specifications, data processing strategy and an analysis of the final results. This 7th ICAG final report supersedes all previously published reports.;Readings were obtained from participating instruments, 19 absolute gravimeters and 15 relative gravimeters. Precise levelling measurements were carried out and all measurements were performed on the BIPM micro-gravity network which was specifically designed for the comparison.
ISSN: 0026-1394

hal-00644529
https://hal.archives-ouvertes.fr/hal-00644529
DOI : 10.1088/0026-1394/48/5/003

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
DNA cytosine methylation is a widely conserved epigenetic mark in eukaryotes that appears to have critical roles in the regulation of genome structure and transcription. Genome-wide methylation maps have so far only been established from the supergroups Archaeplastida and Unikont. Here we report the first whole-genome methylome from a stramenopile, the marine model diatom Phaeodactylum tricornutum. Around 6% of the genome is intermittently methylated in a mosaic pattern. We find extensive methylation in transposable elements. We also detect methylation in over 320 genes. Extensive gene methylation correlates strongly with transcriptional silencing and differential expression under specific conditions. By contrast, we find that genes with partial methylation tend to be constitutively expressed. These patterns contrast with those found previously in other eukaryotes. By going beyond plants, animals and fungi, this stramenopile methylome adds significantly to our understanding of the evolution of DNA methylation in eukaryotes.
ISSN: 2041-1723

hal-01545322
https://hal.archives-ouvertes.fr/hal-01545322
DOI : 10.1038/ncomms3091

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
P>The Strait of Hormuz area is a transition zone between the continental collision of the Zagros (west) and the subduction of an oceanic part of the Arabian Plate beneath the Makran wedge (east). Geology and recent GPS measurements indicate that about 15 mm yr-1 of relative motion in N10 degrees E direction is accommodated by two major fault systems: (1) the NNW-trending Minab-Zendan-Palami (MZP) fault system that connects the Main Zagros Thrust (MZT) to the inner Makran thrust system and the Frontal subduction thrust and (2) the N-trending Sabzevaran-Kahnuj-Jiroft (SKJ) fault system that bounds the Jazmurian depression to the west. We use dense GPS measurements along four transects across these fault systems in order to determine the strains spatial distribution. The northern GPS transect confirms the total fault slip rates for both fault systems estimated by the tectonic analyses (about 10 and 7.3 mm yr-1 in N10 degrees direction across the MZP and SKJ fault systems, respectively). For both fault systems, the elastic deformation spreads over shear zones that are several tens of kilometres wide. However, transects located close to latitude 27 degrees N reveal a much narrower shear zone (similar to 10 km) for the MZP fault system. Moreover, we confirm that most of the present-day strain is transferred towards the frontal subduction thrust rather than towards the inner Makran thrusts. In order to complement this new GPS velocity field with spatially dense measurements, we processed a set of ERS radar images by the radar interferometry (InSAR) technique. We used both a 'stacking' and a 'persistant-scatterers' approach to differentiate the ground deformation signal which spatial gradient is expected to be very low, from the atmospheric signal. Results from these interferograms appear to be relatively in agreement with the GPS-determined strain distribution. Nevertheless, they confirm the absence of any superficial creep behaviour since no sharp discontinuity on interferometric phase can be noted on any interferogram. Finally, we use a purely kinematic 'block model' inversion process to calculate slip rates and locking depths for each fault system from our GPS measurements. These models suggest that the relative quiescence over the last 200 yr has certainly produced a slip deficit as high as 2 m. So, we may wonder if the MZP fault system is not late in the interseismic phase of its earthquake cycle.
ISSN: 0956-540X

hal-00429386
https://hal.archives-ouvertes.fr/hal-00429386
DOI : 10.1111/j.1365-246X.2009.04321.x