Éditeur(s) : INRA : Institut National de la Recherche Agronomique Université des Antilles. Service commun de la documentation
Extrait de : 52e congrès annuel de la Société caribéenne des plantes alimentaires / 52nd annual meeting of the Caribbean food crops society (CFCS), du 10 au 16 juillet 2016. INRA, CFCS
Description : In the new context of the agro-ecological transition, present agricultural systems will have to produce more and better in a more constraint world. Mixed crop livestock systems (MCLS) represent sound alternative ways to progressively achieve these goals through crop-livestock integration (CLI). CLI exploits the synergies between cropping and livestock systems through organic fertilization with manure or plant association, use of crop residues to feed livestock, .... It offers many opportunities to improve productivity, as well as to increase resource use efficiency and improve the resilience of the whole farming system. In the scientific literature, authors advocate the interest of MLCS and CLI, based on theoretical considerations, modelling and empirical evidence from local case studies. But these studies do not clearly identify the respective roles of diversity of activities and CLI management practices in improving performances at the level of the whole farming system. Our aim was thus to assess CLI at farm scale in a range of MCLS and to explain farm performances by analyzing the combination of activities and the level of integration. We conducted our analyses in Guadeloupe, (French West Indies), where MCLS and CLI are complex but important challenges for local agricultural. In order to analyze CLI in a holistic and systemic way, we applied a method traditionally used in ecology, ecological network analysis, to study the structure, functioning and performance of agrosystems. This method was implemented on a range of Guadeloupian MCLS where CLI practices where identified. Nitrogen was retained to conduct the analysis due to its central role for both animal and vegetal productions. The ENA method allows an estimation of productivity, resilience, efficiency, productivity and self- sufficiency of the flows network. Our results show that 1/ efficiency and resilience appear correlated to the complexity and intensity of the network of flows; 2/ efficiency and resiliency are positively correlated when we consider them in terms of N flows; 3/ in the Guadeloupian context, CLI concerns mainly specific practices, as feeding pigs with a wide range of crop residues and organic fertilization of small market gardens and plots used to grow tubers. But at whole system level, CLI remains rare and mainly depends on conventional management practices as mineral fertilization and animal complementation of some farming activities as sugar cane, cattle breeding and banana. Moreover, the combination of productions implemented determines the potential of CLI and related performances linked to relative N efficiency of each production. Consequently, performance and especially efficiency and self-sufficiency depend more on the nature of the activity than on CLI management practices. There is still a gap between theoretical studies and CLI in practice, even though CLI is more complicated than simple flows and provides other services and functions. Dans le nouveau contexte de la transition agro-écologique, les systèmes agricoles actuels devront produire plus et les améliorer dans plus de monde de contrainte. Les systèmes mélangés de bétail de culture (MCLS) représentent des manières alternatives saines d'atteindre progressivement ces buts par l'intégration de culture-bétail (CLI). Le CLI exploite les synergies entre l'emblavage et les systèmes de bétail par la fertilisation organique avec l'association d'engrais ou d'usine, utilisation des résidus de culture d'alimenter le bétail,?. Il donne beaucoup d'occasions d'améliorer la productivité, aussi bien que d'augmenter l'efficacité d'utilisation de ressource et d'améliorer la résilience du système d'exploitation agricole entier. Dans la littérature scientifique, les auteurs préconisent l'intérêt de MLCS et de CLI, basé sur des considérations théoriques, modeler et des preuves empiriques des études de cas locales. Mais ces études n'identifient pas clairement les rôles respectifs de la diversité des activités et des pratiques de gestion de CLI en améliorant des interprétations au niveau du système d'exploitation agricole entier. Notre but était ainsi d'évaluer le CLI à l'échelle de ferme dans une gamme de MCLS et d'expliquer des interprétations de ferme en analysant la combinaison des activités et du niveau de l'intégration. Nous avons réalisé nos analyses en Guadeloupe, (des Antilles françaises), où MCLS et le CLI sont des défis complexes mais importants pour agricole local. Afin d'analyser le CLI d'une manière holistique et systémique, nous avons appliqué une méthode traditionnellement employée en écologie, analyse réseau écologique, pour étudier la structure, le fonctionnement et l'interprétation des agrosystems. Cette méthode a été appliquée sur une chaîne de Guadeloupian MCLS où des pratiques en matière de CLI où identifiée. L'azote a été maintenu pour réaliser l'analyse due à son rôle central pour les productions animales et végétales. La méthode d'ENA permet une évaluation de la productivité, de la résilience, de l'efficacité, de la productivité et de l'autosuffisance du réseau d'écoulements. Nos résultats prouvent que 1 efficacités et résiliences semblent corrélées avec la complexité et l'intensité du réseau des écoulements ; 2 efficacité et élasticité sont franchement corrélés quand nous les considérons en termes d'écoulements de N ; 3 dans le contexte de Guadeloupian, CLI concerne principalement des pratiques spécifiques, en tant que les porcs de alimentation par un large éventail de résidus de culture et de fertilisation organique de petits jardins du marché et complots employés pour cultiver des tubercules. Mais à au niveau système entier, le CLI demeure rare et dépend principalement des pratiques de gestion conventionnelles en tant que complémentation minérale de fertilisation et d'animal de quelques activités agricoles comme canne à sucre, élevage et banane. D'ailleurs, la combinaison des productions mises en application détermine le potentiel du CLI et des interprétations relatives liés à l'efficacité relative de N de chaque production. En conséquence, l'interprétation et particulièrement l'efficacité et l'autosuffisance dépendent davantage de la nature de l'activité que sur des pratiques de gestion de CLI. Il y a toujours un espace entre les études et le CLI théoriques dans la pratique, quoique le CLI soit plus compliqué que des écoulements simples et fournisse d'autres services et fonctions.
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V16247
V16247

Résumé : From the PNCR, GAP MPs free to vote conscience on gay rights bill By Johann Earle Stabroek News June 11, 2003 The PNCR will allow its members to vote their conscience on the controversial Constitution (Amendment) Act of 2001 which seeks to prevent discrimination against persons on the basis of their sexual orientation and other grounds. A number of religious organisations are opposed to the passage of the bill because it includes sexual orientation as one of the grounds. They are concerned that it could lead to a legalisation of homosexual relations and demands for recognition of gay marriages among other things. PNCR Member of Parliament (MP) Vincent Alexander told a forum at the National Library on Saturday, that the Bill did not seek to legalise homosexuality, but to ensure that persons would not be discriminated against based on their sexual preferences. He was one of two parliamentarians who showed up - the other being PNCR member, Myrna Peterkin. The forum was organised by Students Against Sexual Orientation Discrimination (SASOD), a group comprising fifteen students from the University of Guyana which was formed about two weeks ago. Alexander expects the vote on the bill to come up before the National Assembly in a matter of months. Paul Hardy, Leader of the Guyana Action Party (GAP), told Stabroek News that his party would not be using the so-called parliamentary whip. He added that GAP took a decision that every member should vote according to his or her own conscience. “We have no right to deny the rights of others based on sexual orientation. [The Bill] will guarantee rights to the homosexual.” GAP is in Parliament as part of an alliance with the Working People’s Alliance. GAP/WPA has two MPs. The bill was met with rejection from some members of the religious community in 2001 and as a result of this, the President did not assent to it. In a statement on Monday, the Central Islamic Organisa-tion of Guyana (CIOG) said that it stood in firm opposition to the Bill. The CIOG says the general purpose of the bill may be commendable and that the organisation’s objection is not based on a willingness to promote discrimination. Rather, the CIOG said, it was based on the fact that specific legal protection on the basis of sexual orientation without definition or qualification gives tacit legitimacy to practices which are considered criminal in Islam. “It is foreseeable that such a legal nod of approval (subtle as it may be) of these practices may pave the way for greater social (or even legal) acceptability in the future which, from the perspective of all Muslims including those in Guyana, is an undesirable and sinful outcome,” the CIOG statement said. At Saturday’s event, Muslim teacher Moulana Mohamed Ali Zenjibari spoke of instances of abuse, discrimination and harsh penalties meted out to gay and lesbian persons in countries such as Iran and Saudi Arabia and noted that the Quran did not sanction such punishments for homosexual behaviour. President of the CIOG, Fazeel Ferouz told Stabroek News that a meeting to discuss a strategy with regards to the bill was planned for tomorrow with various religious groups. Stabroek News tried to get a comment on the issue from the PPP/C but to no avail. ROAR leader, Ravi Dev said that his party was now having discussions on the issue. ROAR feels that it is an important question which has to do with morality and should be discussed across the country. He added legislators had to be in tune with their constituents on the issue. SASOD is lobbying for the legislation through the sensitisation of MPs. Keimo Benjamin, a law student at UG, gave a presentation based on the jurisprudential aspects of the discussion on sexual orientation. He argued that morality should not be the only guiding principle on which to base the laws. Sexual activities between two consenting male adults in private could not be equated with a violation of a person’s rights, he said, making the point that the thrust of his presentation was not whether homosexuality was wrong, but whether it violated the rights of others. He said that the attitudes of some towards this subject were based on preconceived notions and prejudices. He cited studies to show that the suppression of certain perceived deviant sexual impulses in persons might do more harm than good. One Harvard University study of teens who said they were gay indicated that those teens were three times more likely to commit suicide. Vidyaratha Kissoon, of Help and Shelter, in his contribution on Saturday, expressed his displeasure at the low turnout at the forum and urged the parliamentarians who showed up to take the message to their colleagues. He noted that because of homophobia, the numerical minority was terrified of speaking out against instances of discrimination. Gays and lesbians in Guyana were subjected to ridicule and abuse, and walk the streets at night not looking for sex necessarily, but for the companionship of persons who empathise with them. During his presentation, Joel Simpson, another member of SASOD, outlined a number of changes made within national jurisdictions that had international implications. One such crucial change was South Africa’s 1996 adoption of a new constitution, making that country the first in the world to expressly include sexual orientation as a prohibited ground of discrimination. It was the first time a developing country had taken the lead with respect to the rights of sexual minorities. He also said that according to Douglas Sanders, a Canadian jurist, the rights of homosexual, bisexual or transsexual men and women had never been officially recognised by the United Nations, despite the fact that international laws on the issue began to emerge at the close of the Second World War. Simpson said that under Article 170 (5), as amended by Section 8 of the Constitution (Amendment) (No. 4) Act 2000, the President is required to assent to any bill which is returned by the National Assembly unaltered after a two-thirds majority within 90 days of its presentation to him. To the parliamentarians present, Simpson stressed that the onus was now on them to adequately represent their constituents which include lesbian, gay, bisexual and transsexual Guyanese. http://www.landofsixpeoples.com/news301/ns306115.htm and Vote on sexual orientation should be a matter of conscience - MP Alexander By Esther Elijah Guyana Chronicle June 8, 2003 PEOPLE’S National Congress (PNC/R) Member of Parliament Mr. Vincent Alexander, said the Opposition will vote on “conscience” when the piece of legislation on sexual orientation is again brought before the National Assembly. “With specific reference to my party, when this Bill gets back to the Parliament in the spirit of the arguments here, we will not use the `whip’. Our party will not say we have to vote for the provision (in the Sexual Orientation Bill). We will allow our members to vote as a matter of conscience,” he told participants gathered in the Conference Room of the National Library. “We feel this is a matter of conscience. You may end up with a collective position but you have to deal with us individually,” Alexander said at a poorly attended public consultation aimed at gaining support for sexual orientation to be considered a fundamental right in Guyana. Alexander, one of the main persons who sat on the Constitutional Reform Commission that addressed this controversial clause, said the legislation was not meant to legalise homosexual activities in Guyana. “It was intended to ensure that persons who have an orientation - a way of thinking - which may or may not lead to a certain activity, to not be discriminated against, in terms of their rights,” he explained. Alexander noted that very often, discussions on the sexual orientation provision in the Bill have led to seepages into other areas where debates centre on the “right to be homosexual.” “I am saying the Bill does not comment on that… However, law is peculiar, especially in a Common Law system. Once you venture out and change the law, very often you open other windows which we cannot definitively say exist or does not exist in advance,” he said. “The fear of some people is that the legislators might say one thing and the Courts will eventually say something else. While some people can’t argue against the law, per say, they will say this has opened a window of opportunity not meant to be opened. So, it is better to stay without a window than open it and then have a possibility of something you didn’t intend to happen - happening sometime in the future.” Alexander added: “I want to say I’ve found this activity to have been rich from the perspective of the amount of research which was done by student (speakers). Without any comment as to whether I agree with the arguments, I would wish that much more research on other issues be done by students, and that at the University (of Guyana) students would find it convenient to have forums on other issues, with the same depth of research for their own intellectual development.” Alexander and other Opposition M.P, Lurlene Nestor were the only three Parliamentarians in attendance at the session organised by the recently formed `Students Against Sexual Orientation Discrimination’ (SASOD), a group that has a membership of 15 mostly University of Guyana (UG) students from various faculties. SASOD was established two weeks ago. With the exception of members of the press, the consultation only managed to attract 11 persons, a handful of who were SASOD members. While congratulating the students for an “insightful” presentation, Nestor pointed out that whether or not she chooses to agree with their position is “another issue” and she is entitled to her “own view”. “The issue of sexual orientation is very `toucheous’ …while we agree with the human rights provisions and all that as a society, we must also revert to our own society. Some of the very critical questions that I would want to ask is whether or not at the society (level) we are ready for that kind of thing,” she remarked. “We cannot, at (any) time, ignore the religious groups in our society. If we look at statistics going back to 1992 from a survey done by the Bureau of Statistics, we would see that a small section of the Guyanese population might be considered as people who do not subscribe to a religious view. While the laws are not necessarily based on moral values, we must acknowledge the fact that we might want to revert to many of the cases that (concern) laws that protect public morality.” Nestor told the speakers at the consultation these were some of the issues that they needed to deal with. She highlighted, too, that what must be examined is the effects of same-sex marriages on society and how this issue must be tackled. “These are some of the things we should consider and I don’t think you dealt with that in the presentations,” Nestor stated, adding that the issues must be addressed “frontally.” “Do we think that with the coming to being of this Bill that there might be quite a number of challenges to the Constitution in relation to the same issue of a man marrying a man? What do we do at the society (level)? Do we recognise that?” were the questions directed at the five speakers at the session. Nestor continued: “There is some argument that says, `Oh the Bill does not promote homosexuality or does not encourage a man to marry (another) man, but if you look at Section (15) that talks about `non-discrimination’ then how can we not, with the passage of this Bill, allow a man not to marry (another) man.” According to Nestor, matters of this nature constitute some of the “inconsistencies” of the Bill. On the argument raised by presenters at the session on who determines what is morality, Nestor said in the concept of democracy it is the people who are the determinants based on a “line of thinking.” She also rebutted on grounds that put the spotlight on teachers who may have been caught “interfering” with their young students and who may subsequently be dismissed from their jobs. “Could you imagine such a person interfering with a boy below age 10 - and by virtue of the fact that the Bill is there, the judges (in the case) will have to use their discretion in terms of what happens. We will have more Constitutional changes and problems (arising with the passage of the Bill).” SASOD member and law student, Joel Simpson, in reply, said he doesn’t think any homosexual in Guyana wants to “run into a church and ask that people marry them or anything of that sort.” At one point likening the church to a “club”, Simpson claimed the church has the right to exclude whomever it wants. He further stated that in accordance with the Constitution, people of the same sex do not currently have the right to marry, and will also not be able to do such an act with the passage of the Bill. However, Simpson said it is possible that the law, with the passage of the Bill, would have to recognise same-sex domestic partnerships in relation to employment benefits, sharing of properties, etc. Simpson said he believes there should be a realm of “public” and “private” morality between consenting adults, and implied that the Bill did not fully give “rights” to homosexuals. But, Nestor interjected: “I am informing you further…that the Sexual Orientation provision has, in fact, in some way recognised the rights of homosexuals and we must accept that.” Meanwhile, there was no vocal Christian representative(s) at the consultation and apart from the two Opposition representatives none other participant gave comments or directed questions at the presenters. Other speakers in support of the sexual orientation clause were: Moulana Mohammed Ali Zenjiban, Assistant Director of the International Islamic College; Denuka Radzik from Red Thread, Keimo Benjamin, UG law student and Vidyartha Kissoon from Help & Shelter. The Sunday Chronicle has been reliably informed that the Georgetown Ministers Fellowship, representing groups of Christian leaders staunchly against sexual orientation as a right in Guyana, have recently prepared a detailed 16-page document outlining issues arising from research to further boost their argument against the inclusion of the clause. The document is yet to be made public. http://www.landofsixpeoples.com/news301/nc306083.htm

Droits : All rights reserved by the source institution.
http://ufdc.ufl.edu/AA00014700/00001

Éditeur(s) : CRPLC : Centre de Recherche sur les Pouvoirs Locaux dans la Caraïbe
Extrait de : "Les entités infra-étatiques et les organisations de coopération et d'intégration régionales" : colloque international, les 25 et 26 mars 2013. Université des Antilles et de la Guyane
Description : "The Americas have a rich history of regional cooperation. In the Caribbean Basin, however, mechanisms for regional cooperation and/or integration have emerged which have sought to transcend the issues of legal status and to address common questions of socio-economic development, democratic institutions and functions. Three regional grouping fall into this category: the Caribbean Community (1937), the Organization of Eastern Caribbean States (1981) and the Association of Caribbean States (1994). This paper will do a comparative survey and analysis of the three organizations. The second part of the paper will examine the specific areas of greatest participation by the non-independent members in the activities of specific regional organizations. The conclusion addresses contemporary themes such as the dynamics of political/constitutional evolution which affect the membership of non-independent territories."
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V13127
V13127

Éditeur(s) : Himalayan Academy Himalayan Academy ( United States )
Résumé : (Funding) Support for the development of the technical infrastructure and partner training provided by the United States Department of Education TICFIA program.
(Acquisition) This article is published in Hinduism Today http://www.hinduismtoday.com and is shared by the author Vidyaratha Kissoon email vidyak1 (at) gmail dot com. The author Vidyaratha Kissoon has proposed the following corrections to the PDF version. Some corrections have been made in the print version and in the online edition. Errata Sheet for "Guyana's Hindus face Gay Quandary" Page 60 1) The caption on the photograph should be "Activists from the Caribbean at a human rights advocacy workshop in Guyana in August 2010" - 2) The line "After being ruled by the Dutch, the Spanish and finally the British ... " should read "After being ruled by the Dutch and the British".. 3) The line 'Revisions and amendments to the constitution are relatively common' to 'Revisions and amendments to the constitution are necessary to achieving this nationhood' 4) The phrase "Congress of Guyana" should be changed to "Parliament of Guyana" Page 61 4) The line "Hindu institutions were mostly absent from the 2001 debate except for a joint statement issued by a few organisations.." should read "Hindu institutions were mostly absent from the 2003 debate except for a joint multifaith statement which included a few organisations .." 6) The comments by Former UN Secretary General Kofi Annan - referred to laws like those in Guyana (the British colonial Caribbean) 7) The last sentence should read "Freedom of worship is ... and each of the main groups has national holidays [Christmas, Easter, Diwali, Phagwah, Eid ul Adha, Youman Nabi] Page 62 8) The line "Pandit Dhanesar was not able.. " to "Pandit Dhanesar did not provide any specific reference in the Vedas. In Guyana, many Pandits sustain traditions a mix of oral and written traditions" 9) The line "Active in helping the gay and lesbian communities, he advocates acceptance." should read "He advocates acceptance .. " The corrected version of the article appears online at http://hinduismtoday.com/modules/smartsection/item.php?itemid=5172

Droits : All rights reserved by the source institution.

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Purpose: Active surveillance is a treatment option for favorable risk prostate cancer. However, data are missing on populations of African descent. We evaluated the safety and benefit of active surveillance in an African Caribbean cohort with favorable risk prostate cancer. Materials and Methods: Between 2005 and 2016, a single center, prospective cohort study was performed in Guadeloupe, French West Indies, including patients on active surveillance who had low risk prostate cancer (prostate specific antigen 10 ng/ml or less and Gleason score 6 or less) or favorable intermediate risk prostate cancer (prostate specific antigen 10 to 20 ng/ml, Gleason score 3 + 4 or less and life expectancy less than 10 years). Treatment was recommended in case of grade progression, increased tumor volume, prostate cancer doubling time less than 36 months or patient wish. Overall survival, disease specific survival and duration of active surveillance were calculated with the KaplanMeier method. Multivariate analysis was performed using the Cox proportional hazards model to identify predictors of active surveillance termination. Results: A total of 234 patients with a median age of 64 years were enrolled in study. Median followup was 4 years (IQR 2.3-5.5). Overall survival at 30 months, 5 years and 10 years was 99.5%, 98.5% and 90.7%, respectively. Disease specific survival at 30 months, and 5 and 10 years was 100%. At 30 months, 5 years and 10 years 72.7%, 52.6% and 40.4% of patients, respectively, remained untreated and on active surveillance. Age (HR 0.96 per additional year, 95% CI 0.93-0.99) and prostate specific antigen density (HR 1.52 per additional 0.1 ng/ml, 95% CI 1.20-1.89) were found to be independent predictors of active surveillance termination. Conclusions: Active surveillance is safe and beneficial for highly selected African Caribbean patients. It seems to be feasible for patients at low risk and intermediate favorable risk. Prostate specific antigen density could help better select these patients.
ISSN: 0022-5347

hal-01519251
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01519251
DOI : 10.1016/j.juro.2016.12.047
PUBMED : 27993665

Éditeur(s) : Springer
Résumé : Batch culture experiments using viral enrichment were conducted to test the response of a coastal bacterial community to autochthonous (i.e., co-existing) or allochthonous riverine viruses. The effects of viral infections on bacterial dynamics and activity were assessed by epifluorescence microscopy and thymidine incorporation, respectively, whereas the effect of viral infection on bacterial community composition was examined by polymerase chain reaction-single strand conformation polymorphism 16S ribosomal RNA fingerprinting. The percentages of high nucleic acid-containing cells, evaluated by flow cytometry, were significantly correlated (r (2) = 0.91, n = 12, p < 0.0001) to bacterial production, making this value a good predictor of active cell dynamics along the study. While confinement and temperature were the two principal experimental factors affecting bacterial community composition and dynamics, respectively, additions of freshwater viruses had significant effects on coastal bacterial communities. Thus, foreign viruses significantly reduced net bacterial population increase as compared to the enrichment treated with inactivated virus. Moreover, freshwater viruses recurrently and specifically affected bacterial community composition, as compared to addition of autochthonous viruses. In most cases, the combined treatment viruses and freshwater dissolved organic matter helped to maintain or even enhance species richness in coastal bacterial communities in agreement to the 'killing the winner' hypothesis. Thus, riverine virus input could potentially influence bacterial community composition of the coastal bay albeit with modest modification of bulk bacterial growth.
Microbial Ecology (0095-3628) (Springer), 2009-02 , Vol. 57 , N. 2 , P. 295-306

Droits : 2009 Springer
http://archimer.ifremer.fr/doc/2009/publication-6636.pdf
DOI:10.1007/s00248-008-9428-1
http://archimer.ifremer.fr/doc/00000/6636/

Éditeur(s) : HAL CCSD
Résumé : Benzophenone derivatives (BPs) are used as UV filters in many different products. These lipophilic compounds were recently described as ubiquitous contaminant of different compartiments of aquatic systems, including fish. In this study, we evaluated estrogenic activity of ten BPs in a model fish species, the zebrafish (Danio rerio), by combining newly developed in vitro and in vivo models. In vitro, three specific zebrafish reporter gene models expressing zebrafish estrogen receptors (ZfERs) in zebrafish hepatic cell line (ZFL) were used.Estrogenic activity of BPs was quantify in vivo by using a newly developed transgenic zebrafish line that expresses green fluorescent protein (GFP) under the control of the cyp19a1b promoter. The cyp19a1b gene codes for the brain aromatase B that is under the control of estrogens. Vitellogenin (Vtg), a marker of estrogenic compound, was used to assess the potential estrogenic effect of certain BPs in male fish. Five of 10 BPs induced an estrogenic activity on the three models: BP2, THB, BP1, 4BP, while BP and 234 BP were non active. We noted diffrence in BPs ranking depending on the zfER subtypes suggesting ?/? receptor selectivity by certain BPs. By quantifying GFP expression in live zebrafish, we confirm the estrogenic activity of some BP, i.e., BP1, THB, 4BP and 44'BP, as shown by their ability to induce GFP in a concentration-dependent manner. However, the ranking of BPs as a function of their estrogenic activity assay is different between models. For instance, 4BP was the most estrogenic compound in vivo but not in vitro. Differences were also noticed regarding the estrogenic activity of BP2. In vitro, BP2 has strong activity but had no effect on GFP in cyp19a1b-GFP embryo. However, BP2 induced strongly Vtg in male. The lack of estrogenic activity of BP2 in embryo may be related to difference of biodisponibility and/or metabolisation of this compound between embryo and adult fish. Our approach allows to characterize the estrogenic potency of emerging pollutants, using innovative in vitro and in vivo assays within a unique model fish species. The differences observed between assays deserve further studies to characterize the behavior of compounds in the different biological models in term of biodisponibility and metabolism.
1. European Conference on the Replacement, Reduction and Refinement of Animal Experiments in Ecotoxicology
Dübendorf, Switzerland

ineris-00971019
https://hal-ineris.archives-ouvertes.fr/ineris-00971019
INERIS : EN-2012-243

Éditeur(s) : Elsevier
Résumé : The individual food-demand behavior of juvenile European sea bass (Dicentrarchus labrax, L.) reared in groups under self-feeding conditions was investigated. The triggering activity on self-feeder, i.e. index of the food-demand activity, agonistic interactions and territorial behavior were monitored for periods of 42 to 68 days in six groups of 50 fish. The specific growth rate was calculated and the brain serotonergic activity was used as a stable index of social stress. Inter-individual differences appeared in triggering activity and three groups were distinguished: 3-5 high-triggering fish, 17-30 low-triggering fish and the remaining individuals were null-triggering fish. There were no significant differences in specific growth rates calculated at the end of the experiment (day 42 or day 68) between individuals with high, low, and null food-demand (ANOVA, p > 0.05). No territorial or agonistic behaviors were observed, however, there were significant differences in brain scrotonergic activity between the three triggering groups (ANOVA, p=0.050 in telencephalon and p=0.004 in cerebellum). Specifically, high-triggering fish had lower serotonergic turnover than low or null-triggering fish. We put forth the hypothesis that fish with low or null-triggering activity could be stressed by the high activity of high-triggering individuals. (c) 2006 Elsevier Inc. All rights reserved.
Physiology & Behavior (0031-9384) (Elsevier), 2007-03 , Vol. 90 , N. 4 , P. 559-566

Droits : 2006 Elsevier Inc. All rights reserved
http://archimer.ifremer.fr/doc/2007/publication-2637.pdf
DOI:10.1016/j.physbeh.2006.11.005
http://archimer.ifremer.fr/doc/00000/2637/

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Sur fond de crise du tourisme au Nord, de la globalisation de l’économie et de l’accélération des mobilités, une évolution des formes de développement touristiques semble à l’œuvre dans les confins géographiques. Dans certains territoires touristiques du fait de conflits dans l’usage des ressources naturelles, des pratiques récréatives alternatives émergent qui combinent une logique économique avec des préoccupations socio-environnementales.Notre article analyse l’apparition du tourisme scientifique dans la région « non-touristique » de Aysén, en Patagonie chilienne. Des acteurs d’un territoire se mobilisent selon des pôles culturels et des axes thématiques autour de projets pilotes, de recherche expérientielle et de médiations scientifiques innovantes. Sur ce front pionnier, un réseau informel d’acteurs coordonne ses actions pour aborder les problématiques sociales et environnementales de leur territoire. Opérateurs et prestataires pour le tourisme scientifique créent de manière participative une offre originale. Un système touristique alternatif, axé sur la protection de l’environnement, de la culture et des dynamiques sociales de la communauté d’accueil, favorise l’acquisition et le partage de savoirs entre scientifiques, acteurs locaux et visiteurs.Le tourisme scientifique s’inscrit-il dans une évolution globale des pratiques touristiques ? En proposant de dépasser les frontières, entre activités récréatives et le travail, de lieux de vie et de loisir, il apparaît comme l’expression d’un « après-tourisme ». L’hybridation des pratiques, une approche scientifique associée à l’esprit de la découverte inhérent au voyage, semble pouvoir relever des défis sociétaux liés à l’essor d’un tourisme globalisé. Alors que le tourisme est pensé depuis longtemps en termes de transfert de compétences, de modèles et d’ingénierie du Nord vers le Sud, une périphérie propose de nouveaux cadres de pensée, d’action et de participation qui renouvellent le sens du voyage.
In the context of a tourism crisis in the north, a globalized economy and an increase of mobility, a change in the forms of tourism development seems to occur in peripheral areas. In some tourism areas and due to conflicts over the use of natural resources, alternative recreational practices arise that combine economic needs and socio-environmental concerns.Our article analyzes the appearance of scientific tourism in the "non-tourist" region of Aysén, in Chilean Patagonia. Actors of a territory unite according to specific cultural poles and thematic axes through experiential research and innovative scientific mediation pilot projects. On this pioneer front, an informal network of stakeholders coordinates its actions to address the social and environmental issues of their territory. Operators and service providers for scientific tourism create an innovative offer in a participatory process. An alternative tourism system, focused on protecting the environment, the culture and social dynamics of the host community, promotes the acquisition and sharing of knowledge between scientists, local actors and visitors.Is scientific tourism part of a global evolution of tourism practices? By proposing to go beyond established boundaries, of recreational activities and work, everyday places and leisure areas, it appears as the expression of an “After-Tourism”. The hybridization of practices, a scientific approach associated with the spirit of the discovery inherent of the travel experience, seems to respond to the challenges of the community confronted to the rise of a globalized tourism. While tourism has always been thought of in terms of transfer of skills, models and engineering from the North to the South, a periphery offers new frameworks of thought, action and participation that renew the meaning of travel.
En un escenario de crisis del turismo en los países desarrollados, de la globalización de la economía y del incremento de las movilidades, una evolución de las formas de desarrollo del turismo parece estar en marcha en los confines geográficos. En ciertos territorios turísticos, debido a los conflictos de uso de los recursos naturales, prácticas recreativas alternativas surgen que combinan una lógica económica con preocupaciones socio-ambientales.El presente artículo analiza el surgimiento del turismo científico en la región “no-turística” de Aysén en la Patagonia chilena. Actores del territorio se unen según polos y temáticas científicas, a través de proyectos pilotos, de investigación experiencial y mediaciones científicas innovadoras. En este frente pionero, una red informal se organiza para abordar las problemáticas sociales y ambientales de su territorio. Operadores y proveedores de servicios para el turismo científico crean de manera participativa una oferta novedosa. Un sistema turístico alternativo, basado en el cuidado del medio ambiente, de la cultura y de las dinámicas sociales del comunidad de acogida, favorece la adquisición y el intercambio de conocimientos entre científicos, actores locales y visitantes. ¿Será la aparición del turismo científico la expresión de una evolución global de las practicas turísticas? Al invitar a que sean sobrepasadas las fronteras, entre actividades recreativas y el trabajo, lugares de vida y sitios de esparcimiento, este se presenta como un “Pos-Turismo”. La hibridación de las prácticas, una aproximación científica asociada al espíritu de descubrimiento inherente del viaje, parece poder resolver los desafíos de nuestras sociedades vinculados al auge de un turismo globalizado. Cuando el turismo suele ser pensado desde hace mucho, como un proceso de transferencia de capacidades, de modelos y de ingenierías, del Norte hacia el Sur, una periferia propone nuevos marcos conceptuales, de acción y de participación, que renuevan el sentido del viaje.
Patagonie

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.11169
http://journals.openedition.org/etudescaribeennes/11169

Éditeur(s) : HAL CCSD
Résumé : International audience
How do we learn to communicate: how do we come to language or how does language come to us? Would it be a question of adaptation to the world by the act of speaking as suggested by J. Bernicot 1 (1992); would man benefit first and foremost from a genetic patrimony that enabled him to make use of language, as N. Chomsky (1985) points out by asking the existence of a competence related to generative mechanisms? J. Bruner (1996) proposes the idea of an education likely to "adapt a culture to the needs of its members and to adapt its members and their ways of learning to the needs of culture". 2. A / Motivations and objects An approach to mother-child relationships (master's thesis in developmental psychology 3, Miehakanda, 1998) has given me the opportunity to highlight the mediation of play in the structuring of relationships between the child with academic difficulties and his parents. The specific framework of this research-action was that of the educational and therapeutic care of children attending primary school (CE1-CLIS-CLAD) 4. These seven children (three girls / four boys) who were reported for various personality and behavioral disorders all had a lack of self-esteem and self-esteem affecting their relationships with those around them (peers, teachers ...).
Comment apprenons-nous à communiquer : comment venons-nous au langage ou comment le langage vient-il à nous ? Serait-ce une question d'adaptation au monde par l'action de parler comme le suggère J. Bernicot 1 (1992) ; l'homme bénéficierait-il prioritairement d'un patrimoine génétique le disposant à faire usage du langage, comme l'indique N. Chomsky (1985) en posant l'existence d'une compétence reliée à des mécanismes génératifs ? J. Bruner (1996) propose l'idée d'une éducation susceptible «d'adapter une culture aux besoins de ses membres et d'adapter ses membres et leurs manières d'apprendre aux besoins de la culture» 2. A/ Motivations et objets Une approche des relations mères-enfants (mémoire de maîtrise de psychologie du développement 3 ; Miehakanda, 1998) m'a donné l'occasion de mettre en évidence la médiation du jeu dans la structuration des rapports entre l'enfant rencontrant des difficultés scolaires et ses parents. Le cadre spécifique de cette recherche-action était celui des prises en charge éducatives et thérapeutiques d'enfants scolarisés à l'école primaire (CE1-CLIS-CLAD) 4. Ces sept enfants (trois filles / quatre garçons) qui étaient signalés pour diverses formes de troubles de la personnalité et du comportement éprouvaient tous un manque de confiance en soi et d'estime de soi affectant leurs rapports avec leur entourage (pairs ; enseignants…).
https://hal.univ-antilles.fr/tel-01658934

ISBN : Livre broché : ISBN-10: 3841633412 ISBN-13: 978-3841633415. 2015, pp 316
tel-01658934
https://hal.univ-antilles.fr/tel-01658934

Éditeur(s) : Elsevier
Résumé : We studied the effects of a lactic acid bacterium, Pediococcus acidilactici (strain MA 18/5M, CNCM), as a dietary probiotic on growth performance and some nutritional and microbiological aspects of the shrimp Litopenaeus stylirostris. Experimental shrimp culture was carried out over 10 weeks, using floating cages of 14 m(2) each set in earthen ponds, in a New Caledonia farm affected by "Summer syndrome", a septicaemic vibriosis caused by Vibrio nigripulchritudo. The experiment design testing probiotic-coated pellets against control was replicated in two earthen ponds. High mortalities, characteristic of Summer syndrome, were observed during the first 2 weeks of the trial. The probiotic improved production in the treated cages from both ponds with increases in the survival rate (7% and 15% respectively) and final biomass (8% and 12% respectively). No differences were recorded among treatments on growth performances, but significant lower food conversion ratios were obtained with probiotic treatment. After 5 weeks of rearing, the Hepatosomatic Index and the adjusted dry weight of the digestive gland were significantly increased by 10% and by 9% respectively in shrimps treated with probiotic. In the meantime, the specific activities of alpha amylase and trypsin in the digestive gland showed a significant effect of the probiotic treatment with respective increases by 35% and 55%. The rise in total trypsin activity following morning feeding was also enhanced by the probiotic treatment (P < 0.001). The highest concentration of probiotic (between 10(4)-10(5) CFU g(-1) of fresh gut) in the shrimp gut was obtained 2 h after feeding. The concentration remained high for 4 h after feeding before decreasing until the next meal. Total bacterial counts on Marine agar and TCBS in the gut were significantly lowered by the probiotic treatment over the 10 weeks of the experiment. Additionally, during the first 2 weeks, prevalence and load of V nigripulchritudo strains in haemolymph was lower in animals fed with the probiotic diet. This study demonstrated, under pond conditions, that feeding shrimp with live terrestrial lactic acid bacteria can be an effective treatment for improving shrimp culture affected by vibriosis. (c) 2008 Elsevier B.V. All rights reserved.
Aquaculture (0044-8486) (Elsevier), 2008-03 , Vol. 275 , N. 1-4 , P. 182-193

Droits : 2008 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/2008/publication-4079.pdf
DOI:10.1016/j.aquaculture.2008.01.011
http://archimer.ifremer.fr/doc/00000/4079/

Éditeur(s) : HAL CCSD
Résumé : International audience
Primary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase. The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy. Many reports suggest that the mitogen-activated protein kinase (MAPK) ERK1/2 can support hepatocyte proliferation in vitro and in vivo and the MEK/ERK cascade acts as an essential element in hepatocyte responses induced by the EGF. Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma. Whereas the strict specificity of action of ERK1 and ERK2 is still debated, the MAPKs may have specific biological functions under certain contexts and according to the differentiation status of the cells, notably hepatocytes. In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells. The possible specificity of ERK1 and ERK2 in normal and transformed hepatocyte will be discussed in regard to other differentiated and undifferentiated cellular models.
International Journal of Hepatology

Droits : info:eu-repo/semantics/OpenAccess
hal-00875664
https://hal.archives-ouvertes.fr/hal-00875664
https://hal.archives-ouvertes.fr/hal-00875664/document
https://hal.archives-ouvertes.fr/hal-00875664/file/TheMAPKMEK12-accepted.pdf
DOI : 10.1155/2012/328372

Éditeur(s) : George A. Smathers Libraries, University of Florida George A. Smathers Libraries, University of Florida ( Gainesville, FL )
Résumé : The UF Smathers Libraries partner with institutions and scholars to host and preserve digital collections, support scholarly publishing with digital collections, and support digital acquisitions to build shared collections. Clear benefits from partnerships are often supported with minimal costs by leveraging UF’s infrastructure for hosting, preservation, publishing, and acquisition. However, digital collections require ongoing support. In addition to the future “care and feeding,” new collections and projects also require support for various needs which may be one-time, infrequent, or a stable and continuous commitment throughout a project. These needs draw from digital curation and other areas (e.g., bulk ingesting materials, training for partners, liaising for grant proposal development, liaising for collection development and outreach, collaboration on activities related to specific projects as with training and outreach). Because of the immediate demands and ongoing commitments required for partnerships, potential new partnerships with the UF Libraries are reviewed for consideration and possible approval. This document provides background on partnerships with the UF Libraries, considerations for reviewing potential new partnerships for approval, and procedures for establishing new partnerships and ensuring optimal ongoing support.

Droits : [cc0] The author dedicated the work to the Commons by waiving all of his or her rights to the work worldwide under copyright law and all related or neighboring legal rights he or she had in the work, to the extent allowable by law.
http://ufdc.ufl.edu/AA00017119/00036

Éditeur(s) : Wiley
Résumé : This paper investigates some economic consequences of creating a marine reserve on both fishing and ecotourism, when the range of controllability of fishing effort is limited and the impact of the reserve on ecosystem is considered. The issue is illustrated by the example of creating a no-take zone in part of a region where fishing is managed through a limited entry license system, and which is inhabited by two interacting stocks: a stock of prey (fish) and a stock of predators (seals). While the former is targeted by commercial fishing, the latter is not subject to harvest but is a potential basis for a commercial non-extractive activity (seal watching). Analysis is conducted with the help of a bioeconomic model combining the features of marine reserve modeling and of multispecies modeling. Following a description of the model, results of several simulation runs are presented. These show that creating a marine reserve has more complex economic implications than predicted in studies focused exclusively on one stock and/or commercial fisheries. More specifically, the model shows that the dynamics of the two interacting stocks reduces the benefits of the no-take zone for the fishing industry, while it makes the creation of this zone provide an opportunity for the development of ecotourism. Due to this dynamics, the model suggests that the optimal size of the reserve is larger when ecotourism is taken into account along with fishing activities.
Natural Resource Modeling (1939-7445) (Wiley), 2002-12 , Vol. 15 , N. 4 , P. 387–411

Droits : 2002 Rocky Mountain Mathematics Consortium
http://archimer.ifremer.fr/doc/00244/35506/34010.pdf
DOI:10.1111/j.1939-7445.2002.tb00095.x
http://archimer.ifremer.fr/doc/00244/35506/

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Parler de « tourisme d’aventure organisé », dans le contexte actuel des pratiques de loisirs en plein air, est-il une aberration ? Cet oxymore ne permettrait-il pas de rendre compte des ambivalences d’une pratique touristique qui aspire à profiter des avantages de la combinaison de ces deux formes de tourisme, d’aventure et organisé ? Le terme « trekking » est considéré à la fois comme un terme spécifique et comme un effet de mode et de marketing. Cette duplicité lui procure sa spécificité : un tourisme fondé sur l’aventure, la nature et la découverte culturelle pourtant inséré dans un système marketing très organisé. Pleine nature, culture, sociabilité sont donc tantôt la principale motivation du voyage, tantôt une des raisons (ou les trois raisons) qui décident le plus souvent à voyager dans les montagnes marocaines. Ainsi, les motivations à participer à un voyage organisé dans l’Atlas marocain deviennent de plus en plus hétérogènes et concernent des publics variés. Les imaginaires et les rêves se retrouvent alors littéralement supplantés par la combinaison, parfois contradictoires, des motivations.Forte d’avoir développé ce type de séjours, l’industrie touristique a ainsi récupéré ces pseudo-imaginaires et on assiste aujourd’hui à l’assimilation de ces derniers par les professionnels et les touristes. Expérience aventureuse et marché de l’aventure se font donc face et encouragent l’émergence d’une nouvelle utopie touristique.
Talking about "organized tourism of adventure" in the present context of outdoor leisure activities, an aberration is it? This oxymoron could be explained by the ambivalence on tourist practices that take advantage of the combination of these two forms of tourism, isn't it? "Trekking" is considered both as a specific term and as a marketing term. This duplicity gives it his specificity: a tourism based on adventure, nature and cultural discovery; nevertheless, it is included into a very organized marketing system. Wilderness, culture, sociability are sometimes the main motivations of a trip in Moroccan mountains, or sometimes they constitute one of the main reasons. In addition, motivations to participate to an organized trip in Atlas are becoming more and more diverse and affect various travelers. Imagination and dreams are supplanted by a combination, sometimes contradictory, of motivations. Tourist industry renewed these pseudo-imagination and we are now seeing their assimilation by both professionals and tourists. Adventurous experiences and industry of adventure face each other and encourage the emergence of a new tourist utopia.
Maroc
Atlas

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.11310
http://journals.openedition.org/etudescaribeennes/11310

Éditeur(s) : HAL CCSD ACSM
Résumé : International audience
PURPOSE AND METHODS: This study was designed to determine whether the physiological responses elicited during the run part of repeated bouts of cycle-run exercise are similar to those required during the run segment of a cycle-run succession. Thirteen male triathletes underwent four successive laboratory trials: 1) an incremental treadmill test, 2) an incremental cycle test, 3) 30 min of cycling followed by 20 min of running (C-R), and 4) five repeated bouts of 6 min of cycling and 4 min of running (X-CR). During the C-R and X-CR trials, venous blood samples were obtained to measure lactate, epinephrine and norepinephrine concentrations. During all trials, ventilatory data were collected every min using an automated breath-by-breath system. RESULTS: The results showed that 1) the cardiorespiratory responses observed during running were similar in the X-CR and C-R trials, 2) the lactate concentration was similar in both trials, 3) the epinephrine concentration was greater (277.9 +/- 11.9 vs 169.8 +/- 86.7 pg x mL(-1), P < 0.025) in X-CR than in C-R, and 4) the norepinephrine concentration was similar in both trials, except at the first cycle-run succession (T1) of X-CR. CONCLUSION: We concluded that 1) multi-block training is a good method to stimulate the specific adaptations required for the cycle-run succession, and particularly for the cycle-run transition, and 2) multi-block training seems to induce a greater catecholaminergic response, which may be due to a combination of an inherent effect of this type of training and the triathletes' relative lack of experience with it. In any case, the efficacy of the multi-block model needs to be more thoroughly evaluated over the course of a longer-term training program.
Medicine & Science in Sports & exercise

hal-00720475
https://hal.univ-antilles.fr/hal-00720475
https://hal.univ-antilles.fr/hal-00720475/document
https://hal.univ-antilles.fr/hal-00720475/file/Article_2_.pdf

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
The Oman ophiolite is regarded as derived from a fast spreading oceanic ridge. As in its present-day marine analogs, expectedly, the gabbro unit crystallized in a large magma chamber underneath a small melt lens. In ophiolites, this melt lens is reduced to a horizon mapped in the field, where the floor and the roof of the melt lens joined. The magmatic activity of the former melt lens has been studied in gabbros located below the melt lens horizon. Beneath a stable melt lens, gabbros subside and drift through the steep walls of the magma chamber as steeply foliated gabbros. In contrast, in unstable melt lenses more specifically considered here, flat-lying gabbros are exposed beneath the lens. These gabbros were settling on the floor while the melt lens was retreating. Their strong magmatic foliations and lineations point to a dynamic deposition on the floor, and lineation trends record the structure of convection rolls within the lens. Time constraints suggest a similar to 100 year periodicity of melt recharge by short and powerful melt pulses followed by a shorter time of convection activity after recharge and a longer period of static magma settling, as recently proposed for the East Pacific Rise. At each new melt pulse, the lens nearly doubles its volume by surface expansion, within a short time lapse, before slowly and progressively retreating to feed crustal accretion. Large horizontal surface inflation of the lens better explains the seawater hydration of the accreting crust than melt lens vertical motion through the lid.
ISSN: 0148-0227

hal-00617452
https://hal.archives-ouvertes.fr/hal-00617452
DOI : 10.1029/2010JB007934

Éditeur(s) : HAL CCSD American Society of Hematology
Résumé : International audience
Polycythemia vera (PV) is characterized by an increased RBC mass, spontaneous erythroid colony formation, and the JAK2V617F mutation. PV is associated with a high risk of mesenteric and cerebral thrombosis. PV RBC adhesion to endothelial laminin is increased and mediated by phosphorylated erythroid Lu/BCAM. In the present work, we investigated the mechanism responsible for Lu/BCAM phosphorylation in the presence of JAK2V617F using HEL and BaF3 cell lines as well as RBCs from patients with PV. High levels of Rap1-GTP were found in HEL and BaF3 cells expressing JAK2V617F compared with BaF3 cells with wild-type JAK2. This finding was associated with increased Akt activity, Lu/BCAM phosphorylation, and cell adhesion to laminin that were inhibited by the dominant-negative Rap1S17N or by the specific Rap1 inhibitor GGTI-298. Surprisingly, knocking-down EpoR in HEL cells did not alter Akt activity or cell adhesion to laminin. Our findings reveal a novel EpoR-independent Rap1/Akt signaling pathway that is activated by JAK2V617F in circulating PV RBCs and responsible for Lu/BCAM activation. This new characteristic of JAK2V617F could play a critical role in initiating abnormal interactions among circulating and endothelial cells in patients with PV.
ISSN: 0006-4971

inserm-00821109
http://www.hal.inserm.fr/inserm-00821109
http://www.hal.inserm.fr/inserm-00821109/document
http://www.hal.inserm.fr/inserm-00821109/file/De_Grandis_Blood_2013.pdf
DOI : 10.1182/blood-2012-07-440487

Éditeur(s) : HAL CCSD
Résumé : International audience
Background: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. Methods: We enrolled 14,005 mothers (2002-2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities was recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case-control studies. Results: Average levels of trihalomethanes ranged from around 10 μg/L to above the regulatory limits in the EU of 100 μg/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (β = 2.2 g in birth weight per 10 μg/L of trihalomethane, 95% confidence interval = 3.3, 7.6). Birth weight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (odds ratio [OR] per 10 μg/L = 1.02, 95% confidence interval = 0.95, 1.10), small-for-gestational age (OR = 0.99, 0.94, 1.03) and preterm births (OR = 0.98, 0.9, 1.05). We found no gene-environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. Conclusions: In this large European study, we found no association between birth outcomes and trihalomethane exposures during pregnancy in the total population or in potentially genetically susceptible subgroups. © 2016 Wolters Kluwer Health, Inc.
Epidemiology

hal-01392115
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01392115
DOI : 10.1097/EDE.0000000000000544
PUBMED : 27468006

Éditeur(s) : Copernicus Gesellschaft Mbh
Résumé : The Mediterranean Sea is one of the most oligotrophic marine areas on earth where nitrogen fixation has formally believed to play an important role in carbon and nitrogen fluxes. Although this view is under debate, the diazotrophs responsible for this activity have still not been investigated in the open sea. In this study, we characterised the surface distribution and species richness of unicellular and filamentous diazotrophs across the Mediterranean Sea by combining microscopic counts with size fractionated in situ hybridization (TSA-FISH), and 16S rDNA and nifH genes phylogenies. These genetic analyses were possible owing to the development of a new PCR protocol adapted to scarce microorganisms that can detect as few as 1 cell ml(-1) in cultures. Low concentrations of diazotrophic cyanobacteria were detected and this community was dominated at 99.9% by picoplankton hybridized to the Nitro821 probe, specific for unicellular diazotrophic cyanobacteria (UCYN). Among filamentous cyanobacteria only 0.02 filament ml(-1) of Richelia were detected in the eastern basin, while small (0.7-1.5 mu m) and large (2.5-3.2 mu m) Nitro821-targeted cells were recovered at all stations with a mean concentration of 3.5 cell ml(-1). The affiliation of the small Nitro821-targeted cells to UCYN-A was confirmed by 16S and nifH phylogenies in the western Mediterranean Sea. In the central and the eastern Mediterranean Sea no 16S rDNA and nifH sequence from UCYN was obtained as cells concentration were close to, or below PCR detection limit. Bradyrhizobium sequences dominated nifH clone libraries from picoplanktonic size fractions. A few sequences of gamma-proteobacteria were also detected in the central Mediterranean Sea. While low phosphate and iron concentrations could explain the absence of Trichodesmium sp., the factors that prevent the development of UCYN-B and C remain unknown. We also propose that the dominating picoplankters probably developed specific strategies, such as associations with protists or particles, and/or photosynthetic activity, to acquire carbon for sustaining diazotrophy.
Biogeosciences (1726-4170) (Copernicus Gesellschaft Mbh), 2011 , Vol. 8 , N. 3 , P. 827-840

Droits : Author(s) 2011. CC Attribution 3.0 License.
http://archimer.ifremer.fr/doc/00133/24392/22416.pdf
DOI:10.5194/bg-8-827-2011
http://archimer.ifremer.fr/doc/00133/24392/