Éditeur(s) : Elsevier
Résumé : The individual food-demand behavior of juvenile European sea bass (Dicentrarchus labrax, L.) reared in groups under self-feeding conditions was investigated. The triggering activity on self-feeder, i.e. index of the food-demand activity, agonistic interactions and territorial behavior were monitored for periods of 42 to 68 days in six groups of 50 fish. The specific growth rate was calculated and the brain serotonergic activity was used as a stable index of social stress. Inter-individual differences appeared in triggering activity and three groups were distinguished: 3-5 high-triggering fish, 17-30 low-triggering fish and the remaining individuals were null-triggering fish. There were no significant differences in specific growth rates calculated at the end of the experiment (day 42 or day 68) between individuals with high, low, and null food-demand (ANOVA, p > 0.05). No territorial or agonistic behaviors were observed, however, there were significant differences in brain scrotonergic activity between the three triggering groups (ANOVA, p=0.050 in telencephalon and p=0.004 in cerebellum). Specifically, high-triggering fish had lower serotonergic turnover than low or null-triggering fish. We put forth the hypothesis that fish with low or null-triggering activity could be stressed by the high activity of high-triggering individuals. (c) 2006 Elsevier Inc. All rights reserved.
Physiology & Behavior (0031-9384) (Elsevier), 2007-03 , Vol. 90 , N. 4 , P. 559-566

Droits : 2006 Elsevier Inc. All rights reserved
http://archimer.ifremer.fr/doc/2007/publication-2637.pdf
DOI:10.1016/j.physbeh.2006.11.005
http://archimer.ifremer.fr/doc/00000/2637/

Éditeur(s) : Elsevier
Résumé : High-resolution sedimentological and micropaleontological studies of several deep-sea cores retrieved from the levees of the Celtic and Armorican turbidite systems (Bay of Biscay - North Atlantic Ocean) allow the detection of the major oscillations of the British-Irish Ice Sheet (BIIS) and 'Fleuve Manche' palaeoriver discharges over the last 30,000 years, which were mainly triggered by climate changes. Between 30 and 20 cal ka, the turbiditic activity on the Celtic-Annorican margin was weak, contrasting with previous stratigraphic models which predicted a substantial increase of sediment supply during low sea-level stands. This low turbidite deposit frequency was most likely the result of a weak activity of the 'Fleuve Manche' palaeoriver and/or of a reduced seaward transfer of sediments from the shelf to the margin. However, two episodes of turbiditic activity increase were detected in the Celtic-Armorican margin, during Heinrich events (HE) 3 and 2. This strengthening of the turbiditic activity was triggered by the meltwater releases from European ice sheets and glaciers favouring the seaward transfer of subglacial material, at least via 'Fleuve Manche' palaeoriver. At around 20 cal ka, a significant increase of turbidite deposit frequency occurred as a response to the onset of the last deglaciation. The retreat of the European ice sheets and glaciers induced a substantial increase of the 'Fleuve Manche' palaeoriver discharges and seaward transfer of continentally-derived material into the Armorican turbidite system. The intensification of the turbiditic activity on the Celtic system was directly sustained by the widespread transport of subglacial sediments from the British-Irish Ice Sheet (BIIS) to the Celtic Sea via the Irish Sea Basin. A sudden reduction of turbiditic activity in the Armorican system, between ca. 19 and 18.3 cal ka, could have been triggered by the first well known abrupt sea-level rise ('meltwater pulse', at around 19 cal ka) favouring the trapping of sediment in the 'Fleuve Manche' palaeoriver valleys and the decrease of the seaward transfer of continentally-derived material. The maximum of turbiditic activity strengthening in the Celtic-Armorican margin, between ca. 18.3 and 17 cal ka, was induced by the decay of European ice sheets and glaciers producing the most extreme episode of the 'Fleuve Manche' palaeoriver runoff and a great seaward transfer of subglacial material into the Bay of Biscay, Between ca. 17.5 and 16 cal ka, the turbiditic activity significantly decreased in both Celtic and Armorican turbidite systems in response to a global re-advance of glaciers and ice sheets in Europe. The last episode of ice sheet retreat, between ca. 16 and 14 cal ka, is well expressed in the Celtic system by a new increase of the turbiditic activity. The major episode of sea-level rise at around 14 cal ka ('Meltwater Pulse 1A'), precluding the seaward transfer of sediments, induced the end of turbiditic activity in both the Celtic and the Armorican system. Although two main phases of global sea-level rise seem to have had an effect on the Celtic-Armorican margin, this work proposes the BUS retreat and associated riverine discharges as the main trigger mechanisms of the turbiditic activity in this region during the last 30,000 years.
Marine Geology (0025-3227) (Elsevier), 2008 , Vol. 247 , N. 1-2 , P. 84-103

Droits : 2008 Elsevier B.V. All rights reserved
http://archimer.ifremer.fr/doc/2008/publication-3729.pdf
DOI:10.1016/j.margeo.2007.08.006
http://archimer.ifremer.fr/doc/00000/3729/

Éditeur(s) : Springer
Résumé : The Golo Margin in eastern Corsica is dissected by four canyons and two gullies which fed turbidite systems. Study of the dispersal of surficial sediments and flow dynamic in the Golo system is based on Kullenberg and interface cores interpreted in relation to a previously published seismic dataset. Cores were described in detail and interpreted within a sedimentary and stratigraphic framework. During the last 42,000 years, gravity processes which occurred in the large systems with a canyon source were mainly slide-induced, differentiated turbulent surges and hyperpycnal flows. Processes occurring in the small system with a gully source are mainly hyperconcentrated and concentrated flows. Deposits from the Corsican Margin can intercalate with products of processes triggered on the Pianosa Ridge located in the eastern part of the basin. During relative sea-level lowstands or during periods of rapid or high-amplitude sea-level fall, only large canyons (South and North Golo) are supplied by carbonate-rich hyperconcentrated and concentrated flows which are channelled in incised valleys on the shelf. During periods of slow or low-amplitude sea-level fall and during sea-level rise, sediments are trapped on a shelf delta and intensely winnowed by shelf hydrodynamic processes. Sand-rich hyperconcentrated and concentrated flows occur. All the systems fed by a canyon are active simultaneously. Gullies form and are active only during periods of sea-level rise. During relative highstands of sea level (Holocene), all the system is draped by hemipelagic sediments. Relative sea-level changes and canyon location relative to river mouths have a strong influence on the nature of sediment input, and the initiation and type of gravity flows which, in turn, control morphology and geometry.
Geo-Marine Letters (0276-0460) (Springer), 2006-12 , Vol. 26 , N. 6 , P. 373-395

Droits : 2006 Springer
http://archimer.ifremer.fr/doc/2006/publication-3594.pdf
DOI:10.1007/s00367-006-0045-z
http://archimer.ifremer.fr/doc/00000/3594/

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras by fusing FasL to domains of the Leukemia Inhibitory Factor receptor gp190 which confer homotypic oligomerization, and analyzed the capacity of these soluble chimeras to trigger cell death. We observed that the most efficient FasL chimera, called pFasL, was also the most polymeric, as it reached the size of a dodecamer. Using a cellular model, we investigated the structure-function relationships of the FasL/Fas interactions for our chimeras, and we demonstrated that the Fas-mediated apoptotic signal did not solely rely on ligand-mediated receptor aggregation, but also required a conformational adaptation of the Fas receptor. When injected into mice, pFasL did not trigger liver injury at a dose which displayed anti-tumor activity in a model of human tumor transplanted to immunodeficient animals, suggesting a potential therapeutic use. Therefore, the optimization of the FasL conformation has to be considered for the development of efficient FasL-derived anti-cancer drugs targeting Fas.
ISSN: 1932-6203

hal-00873684
https://hal.archives-ouvertes.fr/hal-00873684
https://hal.archives-ouvertes.fr/hal-00873684/document
https://hal.archives-ouvertes.fr/hal-00873684/file/Functional_Characterization-accepted.pdf
DOI : 10.1371/journal.pone.0054000

Éditeur(s) : NRC
Résumé : In self-feeding conditions, a few individual sea bass (Dicentrarchus labrax (L., 1758)) display strong activity in striking the food dispenser, whereas the remaining individuals of the group actuate the feeder weakly or never. Here, we investigated the effects of removal of the individuals showing dominant activity on the social and feeding behaviours in groups of juvenile sea bass. Following removal, new fish showing a dominant self-feeding activity quickly appear. They always come from the group of fish that have a low number of triggering actuations. This observation shows that it takes less time, about 5 days after the removal of dominant triggerers vs. 14 days at the beginning, for the re-establishment of the behavioural structure, suggesting the possibility of social transmission between individuals. The fish that show weak triggering activity seem to reach the high-food triggering level without obvious signs of competition. This experiment reveals the importance of the food-demand behavioural structure: the fish displaying the highest activity lead to a general food distribution and play a dominant role in feeding the entire group. Functional plasticity in this role within individuals is also demonstrated, indicating that the high-triggering function is essential for the group and not for the individual themselves.
Au sein d'un groupe de bars (Dicentrarchus labrax (L., 1758)) placés en auto-nourrissage, quelques individus disposent d'une activité forte de déclenchement volontaire du distributeur d'aliments. Les autres poissons du groupe disposent d'une activité de demande faible voire nulle. Ici, nous avons étudié l'impact du retrait des poissons à forte activité sur le comportement alimentaire et social de groupes de bars juvéniles. De nouveaux individus à forte activité réapparaissent rapidement, provenant exclusivement de la classe de poissons de faible demande. Cinq jours en moyenne suffisent après le retrait, contre 14 jours au début de l'expérience, pour que la structure comportementale se rétablisse suggérant l'existence d'une transmission sociale entre les individus. Ces poissons de faible activité semblent de plus atteindre leur nouvelle fonction sans aucun signe de compétition. Cette expérience révèle d'abord l'importance de la structure de la demande alimentaire puisqu'elle réapparaît après le retrait. Elle montre également que l'activité des forts manipulateurs conduit à une distribution générale de l'aliment et contribue à nourrir le groupe en entier. L'étude montre enfin une plasticité fonctionnelle indiquant que seule la fonction de manipulateur fort est essentiel pour la stabilité du groupe, non l'identité des individus par elle-même.
Canadian journal of zoology (0008-4301) (NRC), 2008-09 , Vol. 86 , N. 9 , P. 1015-1023

Droits : 2008 NRC Canada
http://archimer.ifremer.fr/doc/2008/publication-4766.pdf
DOI:10.1139/Z08-077
http://archimer.ifremer.fr/doc/00000/4766/

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
A decreased global autonomic nervous system (ANS) activity and increased sympathetic activation in patients with sickle cell anemia (SCA) seem to worsen the clinical severity and could play a role in the pathophysiology of the disease, notably by triggering vaso-occlusive crises. Because exercise challenges the ANS activity in the general population, we sought to determine whether a short (,15 min) and progressive moderate exercise session conducted until the first ventilatory threshold had an effect on the ANS activity of a group of SCA patients and a group of healthy individuals (CONT group). Temporal and spectral analyses of the nocturnal heart rate variability were performed before and on the 3 nights following the exercise session. Standard deviation of all normal RR intervals (SDNN), total power, low frequencies (LF) and high frequencies powers (HF) were lower but LF/HF was higher in SCA patients than in the CONT group. Moderate exercise did not modify ANS activity in both groups. In addition, no adverse clinical events occurred during the entire protocol. These results imply that this kind of short and moderate exercise is not detrimental for SCA patients.
ISSN: 1932-6203

hal-01136725
https://hal.univ-antilles.fr/hal-01136725
https://hal.univ-antilles.fr/hal-01136725/document
https://hal.univ-antilles.fr/hal-01136725/file/Hedreville%20et%20al.%20-%202014%20-%20Acute%20moderate%20exercise%20does%20not%20further%20alter%20the%20autonomic%20nervous%20system%20activity%20in%20patients%20with%20sick%282%29.pdf
DOI : 10.1371/journal.pone.0095563

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The El Oro metamorphic province of SW Ecuador is a composite massif made of juxtaposed terranes of both continental and oceanic affinity that has been located in a fore-arc position since Late Paleozoic times. Various geochemical, geochronological, and metamorphic studies have been undertaken on the El Oro metamorphic province, providing an understanding of the origin and age of the distinct units. However, the internal structures and geodynamic evolution of this area remain poorly understood. Our structural analysis and thermal modeling in the El Oro metamorphic province show that this fore-arc zone underwent four main geological events. (1) During Triassic times (230–225 Ma), the emplacement of the Piedras gabbroic unit at crustal-root level (~9 kbar) triggered partial melting of the metasedimentary sequence under an E-W extensional regime at pressure-temperature conditions ranging from 4.5 to 8.5 kbar and from 650 to 900°C for the migmatitic unit. (2) At 226 Ma, the tectonic underplating of the Arenillas-Panupalí oceanic unit (9 kbar and 300°C) thermally sealed the fore-arc region. (3) Around the Jurassic-Cretaceous boundary, the shift from trench-normal to trench-parallel subduction triggered the exhumation and underplating of the high-pressure, oceanic Raspas Ophiolitic Complex (18 kbar and 600°C) beneath the El Oro Group (130–120 Ma). This was followed by the opening of a NE-SW pull-apart basin, which tilted the massif along an E-W subhorizontal axis (110 Ma). (4) In Late Cretaceous times, an N-S compressional event generated heterogeneous deformation due to the presence of the Cretaceous Celica volcanic arc, which acted as a buttress and predominantly affected the central and eastern part of the massif.
ISSN: 0278-7407

hal-01115714
https://hal.archives-ouvertes.fr/hal-01115714
DOI : 10.1002/2014TC003618

Éditeur(s) : Pergamon-elsevier Science Ltd
Résumé : The late Quaternary has experienced large glacial/interglacial climatic variations and related 10's to 100 meters high-amplitude sea level fluctuations at Milankovich frequencies from 10's to 100 kyr during which carbonate platform tops have been exposed and re-flooded in many occasions. This study focuses on the accumulation of calci-turbidites, the aragonite onset/sharp increase in fine sediments and their timing in deep basins adjacent to carbonate platforms. A particular emphasis is developed on the occurrence of the first gravity flow event and aragonite onset/sharp increase and their linkage to the initial re-flooding of the platform tops during deglaciations. Three basins adjacent to isolated platforms in the Bahamas, the Northern Nicaragua Rise, and the Gulf of Papua, were selected to represent pure carbonate versus mixed systems, in quiescent versus tectonically active settings, and various carbonate bank top morphologies, ranging from atoll to relatively deeply and narrowly flooded flat top banks. In spite of these differences, each record illustrates a clear relationship between the timing of platform top re-flooding and initiation of significant carbonate export by gravity flows and low-density plumes into the surrounding basins. The concept of "re-flooding window" is introduced to characterize the prolific period of time during which bank and atoll-tops are flooded enough to produce large export of bank-derived aragonite and of calci-turbidites in adjacent basins. According to our datasets, the main re-flooding windows have occurred mainly on the last part of the sea level rise at each glacial termination (T), those periods being marked by some of the highest rates of sea level rise. The analysis of a long-piston core from the earthquakes-prone Walton Basin (Northern Nicaragua Rise) demonstrates that sea level, not seismic activities, played a major role as trigger mechanism for the initiation of gravity flows since the last four glacial/interglacial transitions, and supports the existence of an extra glacial termination during the early portion of the transition from MIS 7.4 to MIS 7.3 (TIIIA). (C) 2010 Elsevier Ltd. All rights reserved.
Quaternary Science Reviews (0277-3791) (Pergamon-elsevier Science Ltd), 2010-08 , Vol. 29 , N. 17-18 , P. 2010-2026

Droits : 2010 Elsevier Ltd All rights reserved.
http://archimer.ifremer.fr/doc/00012/12298/9095.pdf
DOI:10.1016/j.quascirev.2010.04.016
http://archimer.ifremer.fr/doc/00012/12298/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We have discovered in a marine core, located 20 km east of the Coastal Range of Taiwan at the top of a 1200 m deep submarine high, sheltered from rivers discharges and gravitational flows, a 23 cm-thick anomalous sequence topped with broken bivalves and wood fragments. Based on radiocarbon dating, we distinguish five sub-events within ∼ 100 yrs, about 3000 years ago. The oldest four sub-events are interpreted as the record of local submarine landslides, likely triggered by clustered earthquakes that are common in this tectonically active area. The last event including shells and wood has a different origin. Despite the high level of climatic and tectonic recent activity, no comparable event has been observed at the same site since that time, making it unique during the last 3.75 ka. Hydrodynamical modeling stimulated with a set of submarine landslide-triggered tsunami sources and combined with the regional oceanic circulation dominated by the Kuroshio Current, allow us to better constrain the transport paths of the suspended material, the expected run-up at the coast, and ultimately the trigger and source that best fit our observations. The Kuroshio Current appears as a strong constraint that generally prevents cross-shore transport of suspended material even during a major tsunami. Since the largest aerial debris flow observed along the east coast of Taiwan during the last 4 ka was synchronous with the marine deposit, our preferred scenario starts with the occurrence of four distinct large earthquakes within less than a century, triggering both submarine and aerial landslides in the study area. Then, a giant typhoon reworked the nearshore material as well as the slided material stored upstream resulting in a debris flow. It deeply modified the surface current, allowing the wood debris and shells to fastly reach the core site.
ISSN: 0040-1951

hal-01467640
https://hal.archives-ouvertes.fr/hal-01467640
DOI : 10.1016/j.tecto.2015.11.001

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aryl hydrocarbon receptor-dependent genomic effects of environmental polycyclic aromatic hydrocarbons (PAHs) have been shown to be modulated by non-genomic protein kinase C (PKC)-related pathways. The present study was designed to determine whether PKC activation may also impair estrogenic genomic response triggered by PAHs. Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed. BZA/PMA cotreatment however failed to alter BZA-mediated increase of activity of a luciferase gene reporter construct driven by an estrogen response element, thus discarding any global effect of PMA toward BZA-triggered estrogen receptor activation. Various chemicals inhibiting PKCs or extracellular signal-regulated kinase (ERK) as well as the knock-down of PKCδ expression counteracted the PMA-mediated increase of pS2 mRNA up-regulation triggered by BZA, demonstrating that it was dependent on PKCs, including PKCδ isoform, and ERKs. This non-genomic modulation of estrogenic effects of PAHs by PKC activation may have to be considered when considering the deleterious effects of these environmental contaminants towards the endocrine system.
ISSN: 0887-2333

inserm-00872862
http://www.hal.inserm.fr/inserm-00872862
DOI : 10.1016/j.tiv.2012.05.006
PUBMED : 22643241

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Several epidemiologic studies have shown an interactive effect of heavy smoking and heavy alcohol drinking on the development of hepatocellular carcinoma. It has also been recently described that chronic hepatocyte death can trigger excessive compensatory proliferation resulting later in the formation of tumors in mouse liver. As we previously demonstrated that both benzo[a]pyrene (B[a]P), an environmental agent found in cigarette smoke, and ethanol possess similar targets, especially oxidative stress, to trigger death of liver cells, we decided to study here the cellular and molecular mechanisms of the effects of B[a]P/ethanol coexposure on cell death. After an 18-h incubation with 100nM B[a]P, primary rat hepatocytes were supplemented with 50mM ethanol for 5 or 8h. B[a]P/ethanol coexposure led to a greater apoptotic cell death that could be linked to an increase in lipid peroxidation. Plasma membrane remodeling, as depicted by membrane fluidity elevation and physicochemical alterations in lipid rafts, appeared to play a key role, because both toxicants acted with specific complementary effects. Membrane remodeling was shown to induce an accumulation of lysosomes leading to an important increase in low-molecular-weight iron cellular content. Finally, ethanol metabolism, but not that of B[a]P, by providing reactive oxygen species, induced the ultimate toxic process. Indeed, in lysosomes, ethanol promoted the Fenton reaction, lipid peroxidation, and membrane permeabilization, thereby triggering cell death. To conclude, B[a]P exposure, by depleting hepatocyte membrane cholesterol content, would constitute a favorable ground for a later toxic insult such as ethanol intoxication. Membrane stabilization of both plasma membrane and lysosomes might be a potential target for further investigation considering cytoprotective strategies.
ISSN: 0891-5849

hal-01018147
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01018147
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01018147/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01018147/file/Cooperative-interaction_final.pdf
PUBMED : 24681337

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
High sea surface temperature accompanied by high levels of solar irradiance is responsible for the disruption of the symbiosis between cnidarians and their symbiotic dinoflagellates from the genus Symbiodinium. This phenomenon, known as coral bleaching, is one of the major threats affecting coral reefs around the world. Because an important molecular trigger to bleaching appears related to the production of reactive oxygen species (ROS), it is critical to understand the function of the antioxidant network of Symbiodinium species. In this study we investigated the response of two Symbiodinium species, from contrasting environments, to a chemically induced oxidative stress. ROS produced during this oxidative burst reduced photosynthesis by 30 to 50% and significantly decreased the activity of superoxide dismutase. Lipid peroxidation levels and carotenoid concentrations, especially diatoxanthin, confirm that these molecules act as antioxidants and contribute to the stabilization of membrane lipids. The comparative analysis between the two Symbiodinium species allowed us to highlight that Symbiodinium sp. clade A temperate was more tolerant to oxidative stress than the tropical S. kawagutii clade F. These differences are very likely a consequence of adaptation to their natural environment, with the temperate species experiencing conditions of temperature and irradiance much more variable and extreme.
ISSN: 0140-7791

hal-01546161
https://hal.archives-ouvertes.fr/hal-01546161
DOI : 10.1111/pce.12825

Éditeur(s) : HAL CCSD Springer Verlag (Germany) Springer Verlag
Résumé : International audience
Replenished axial melt lenses at fast-spreading mid-oceanic ridges may move upward and intrude into the overlying hydrothermally altered sheeted dikes, resulting in high-grade contact metamorphism with the potential to trigger anatexis in the roof rocks. Assumed products of this process are anatectic melts of felsic composition and granoblastic, two-pyroxene hornfels, representing the residue after partial melting. Integrated Ocean Drilling Program Expeditions 309, 312, and 335 at Site 1256 (eastern equatorial Pacific) sampled such a fossilized oceanic magma chamber. In this study, we simulated magma chamber roof rock anatectic processes by performing partial melting experiments using six different protoliths from the Site 1256 sheeted dike complex, spanning a lithological range from poorly to strongly altered basalts to partially or fully recrystallized granoblastic hornfels. Results show that extensively altered starting material lacking primary magmatic minerals cannot reproduce the chemistry of natural felsic rocks recovered in ridge environments, especially elements sensitive to hydrothermal alteration (e.g., K, Cl). Natural geochemical trends are reproduced through partial melting of moderately altered basalts from the lower sheeted dikes. Two-pyroxene hornfels, the assumed residue, were reproduced only at low melting degrees (<20 vol%). The overall amphibole absence in the experiments confirms the natural observation that amphibole is not produced during peak metamorphism. Comparing experimental products with the natural equivalents reveals that water activity (aH2O) was significantly reduced during anatectic processes, mainly based on lower melt aluminum oxide and lower plagioclase anorthite content at lower aH2O. High silica melt at the expected temperature (1000–1050 °C; peak thermal overprint of two-pyroxene hornfels) could only be reproduced in the experimental series performed at aH2O = 0.1.
ISSN: 0010-7999

hal-01174139
https://hal.archives-ouvertes.fr/hal-01174139
DOI : 10.1007/s00410-015-1136-5

Éditeur(s) : Inter-research
Résumé : Vibriosis is a major disease problem in shrimp aquaculture. 'Syndrome 93' is a seasonal juvenile vibriosis caused by Vibrio penaeicida which affects Litopenaeus stylirostris in grow-out ponds in New Caledonia. This study assessed the toxic activities of extracellular products (ECPs) from V: penaeicida, V. alginolyticus and V, nigripulchritudo using in vivo injections in healthy juvenile L. stylirostris (= Penaeus stylirostris) and in vitro assays on shrimp primary cell cultures and the fish cell line epithelioma papulosum cyprini (EPC). Toxic effects of ECPs were demonstrated for all pathogenic Vibrio strains tested both in vivo and in vitro, but for shrimp only; no effect was observed on the fish cell line. ECP toxicity for New Caledonian V. penaeicida was found only after cultivation at low temperature (20 degrees C) and not at higher temperature (30 degrees C). This points to the fact that 'Syndrome 93' episodes are triggered by temperature drops. The assays used here demonstrate the usefulness of primary shrimp cell cultures to study virulence mechanisms of shrimp pathogenic bacteria.
Diseases Of Aquatic Organisms (0177-5103) (Inter-research), 2000-03 , Vol. 40 , N. 2 , P. 101-107

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00000/10543/7600.pdf
DOI:10.3354/dao040101
http://archimer.ifremer.fr/doc/00000/10543/

Éditeur(s) : HAL CCSD IOP Publishing
Résumé : Radioactive pollutants are naturally present in microelectronic device materials and can be an issue for the reliability of devices. The main concern is alpha emitters that produce high-energy particles (a few MeV) that ionize the semiconductor and then trigger soft errors. The question is to know what kinds of radionuclides are present in the device, their location in the device and the abundance of each species. In this paper we describe tools that are required to address the issue of radioactive pollutants in electronic devices.
ISSN: 0268-1242

hal-01504448
https://hal.archives-ouvertes.fr/hal-01504448
DOI : 10.1088/1361-6641/aa5479

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Miocene (17-11 Ma) magmatic activity in the Kabylies emplaced K-rich (and minor medium-K) calc-alkaline plutonic and volcanic rocks in five zones, delineating a ∼450 km long EW trending strip located along the northern coast of Algeria, between Annaba and Algiers. Their most likely source is the Kabylian subcontinental lithospheric mantle previously metasomatized during the Paleogene subduction of the Tethys oceanic lithosphere. Our preferred tectono-magmatic model involves a Tethyan slab detachment combined with African mantle delamination and crustal stacking, leading to the superimposition of the African continental crust over the Kabylian metasomatized lithospheric mantle. At ca. 17 Ma, the asthenospheric upwelling arising from lithospheric delamination and Tethyan slab tear triggered the thermal erosion of the latter mantle, inducing its partial melting. The corresponding mafic medium-K calc-alkaline magmas interacted with the African basement units during their ascent, generating intermediate to felsic K-rich calc-alkaline melts that display a characteristic trace element and isotopic crustal signature. Later on, slab tears propagated eastward and westward, promoting slab rollback perpendicular to plate convergence and inducing the emplacement of magmatic rocks of decreasing ages from central-eastern Algeria towards Tunisia and Morocco.
ISSN: 0899-5362

hal-01467997
https://hal.archives-ouvertes.fr/hal-01467997
DOI : 10.1016/j.jafrearsci.2016.10.005

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Imaging deep active volcanic areas remains a challenge in our understanding of their activity and evolution, especially in subduction zones. Study of magnetic anomalies is appropriate to access such dynamics in depth. The magnetic anomaly pattern of the Lesser Antilles Arc (LAA) subduction is studied through Curie Point Depth (CPD), interpreted as the depth of the 580 °C isotherm, and developed to better assess the deep thermal structure of the arc. The depth of the estimated CPD exhibits a complex topography. Keeping in mind the overall uncertainty associated with this method, a main doming is evidenced below the Guadeloupe archipelago. Its apex is shifted towards the ancient arc, suggesting a very hot state of the fore-arc/arc domain. To better understand the LAA thermal state, we perform 2D thermo-mechanical simulations of the subduction zone. Recalling that magnetite is a serpentinization by-product, we simulate water transfer triggered by slab dehydration to test the assumption of fore-arc serpentinization suggested by the positive magnetic anomaly in the vicinity of the Guadeloupe archipelago. In this area, the subduction-induced arc lithosphere hydration and related weakening trigger a fast heating of the upper plate by basal convective removal. This process of fast arc lithosphere thinning may apply where simultaneously the volcanic arc is split in two and normal convergence is high enough. As serpentinization strongly decreases P-wave velocity, we propose a new interpretation of a published seismic profile below Guadeloupe. The seismic layer previously interpreted as the arc lower crust may rather be a layer of serpentinized mantle, as supported by spatial correlations between gravimetric and magnetic anomalies. Consequently, at the scale of Guadeloupe Island, the fore-arc Moho would be shallower than initially assumed, with a dome shape more consistent with both the extensive deformation active since the Oligocene in the inner fore-arc and the CPD doming.
ISSN: 0040-1951

Droits : http://creativecommons.org/licenses/by-nc-nd/
insu-01505300
https://hal-insu.archives-ouvertes.fr/insu-01505300
https://hal-insu.archives-ouvertes.fr/insu-01505300/document
https://hal-insu.archives-ouvertes.fr/insu-01505300/file/Gailler-2017.pdf
DOI : 10.1016/j.tecto.2017.03.014

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Assessing seismic hazards remains one of the most challenging scientific issues in Earthsciences. Deep tectonic processes are classically considered as the only persistentmechanism driving the stress loading of active faults over a seismic cycle. Here we show via amechanical model that erosion also significantly influences the stress loading of thrust faultsat the timescale of a seismic cycle. Indeed, erosion rates of about B0.1–20mmyr1, asdocumented in Taiwan and in other active compressional orogens, can raise the Coulombstress by B0.1–10 bar on the nearby thrust faults over the inter-seismic phase. Masstransfers induced by surface processes in general, during continuous or short-lived andintense events, represent a prominent mechanism for inter-seismic stress loading offaults near the surface. Such stresses are probably sufficient to trigger shallow seismicity orpromote the rupture of deep continental earthquakes up to the surface.
ISSN: 2041-1723

insu-01087103
https://hal-insu.archives-ouvertes.fr/insu-01087103
https://hal-insu.archives-ouvertes.fr/insu-01087103/document
https://hal-insu.archives-ouvertes.fr/insu-01087103/file/Steer2014_NatureComm_accepted.pdf
DOI : 10.1038/ncomms6564

Éditeur(s) : HAL CCSD
Résumé : Taiwan is a young mountain belt, known as one of the most active area in the world. Since the beginning of the 20th century more than twenty _ Mw 7 earthquakes have struck the island. However, the occurrence of larger events (_Mw 8) is still a matter of debate. In this framework it is of key importance to obtain longer record in order to evaluate the occurrence of large past earthquakes. The sub-aqueous paleoseismology, based on the record of the sedimentary gravity deposits, appears as a serious alternative to approach this thematic and is a rapidly advancing field that has the potential to illuminate the long-term history of seismicity.The first part of this work was to investigate the present sedimentary systems off east Taiwan, essential to understand the morphosedimentary features, sedimentary facies and processes governing the evolution of the submarine slope, and the controlling factors of the recent sedimentation. Our results showed that the offshore slope east Taiwan is affected by a variety of sedimentary systems and processes, and that turbidity currents appear as the main erosional processes covering nearly 60% of the sedimentary record. Turbidity currents are generated by distinct controlling factors such as tectonic and climatic activity that enabled us to define twoend-members relative to turbidity currents initiation: Turbidity currents preconditioned by tectonic activity and triggered by earthquakes shaking and likely deposited into intra-slope basin and turbidity currents driven by climatic activity such as extreme floods or typhoons, generated in basin directly connected with onland rivers.The second part consisted to apply a paleoseismic approach, based on turbidites record, at two time-scales. First, we tested and validated the method by correlating turbidites deposits with instrumental earthquakes. Then, once calibrated we extended the time-series back in time. We dated the three most recent turbidites layers circa 2001 ± 3 AD, 1950 ± 5 AD and 1928 ± 10 AD. Using empirical relationship that link peakground acceleration, distance and magnitude to calibrate the seismic sources, we correlate these three turbidites with instrumental earthquakes: the Chengkong Earthquake 12/10/2003 (Mw 6.8), the 11/24/1951 Taitung Earthquake (Mw 7.1) and the 9/4/1935 Lutao Earthquake (Mw 7.0) respectively. Applying criteria to discriminating the different triggering mechanisms for turbidity current generation, we propose that earthquakes are the main triggering mechanisms. Dating and age modeling provided a part of the chronology of extreme events since the last 3000 years and allowed us to estimate return time for earthquakes Mw _ 6.8.This work represents a good starting-point for future investigations in order to better assess Holocene time series of extreme events.
La chaine de Taïwan représente l’une des zones les plus actives au monde. Depuis le début du XXe siècle, plus d’une vingtaine de séismes _Mw 7 ont affecté l’île. Cependant la probabilité d’occurrence de séismes plus importants (_Mw 8) est toujours matière à débat. Dans un tel contexte, il apparait donc important d’obtenir des enregistrements plus anciens pour évaluer l’occurrence de tels évènements. La paléosismologie marine, basée sur l’enregistrement des dépôts issus de la sédimentation gravitaire, apparait comme une alternative sérieuse afin d’illuminer l’histoire de la sismicité sur des périodes anciennes. Ce travail de thèse apporte de nouvelles contraintes sur l’histoire sismique au large, à l’est de Taïwan, au cours des derniers 3000 ans.La première partie de ce travail consiste à caractériser les systèmes sédimentaires récents. Cette étape fut essentielle pour la compréhension des processus, faciès sédimentaires et les facteurs de contrôle de la sédimentation qui régissent l’évolution de la pente sous-marine. Ces résultats ont montré que l’Est de Taïwan est caractérisé par une grande variabilité de processus et que les courants de turbidité dominent l’enregistrement sédimentaire.Les courants de turbidité sont générés par deux facteurs distincts : l’activité tectonique/sismique et l’activité climatique. La deuxième partie de ce travail est consacrée à l’approche paléosismique en utilisant les dépôts de turbidités comme marqueurs des paléoséismes. Pour ce faire, nous avons dans un premier temps testé et validé l’approche à l’échelle du siècle dernier. Ensuite une fois calibré, nous avons pu étendre les séries temporelles à l’échelle de l’Holocène. Nous avons daté les trois plus récents évènements turbiditiques autour de 2001 ± 3 AD, 1950 ± 5 AD et 1928 ± 10 AD. En utilisant des relations empiriques intégrant magnitude, distance et valeur du "peak ground acceleration", nous avons pu calibrer la source sismique et ainsi corréler ces trois turbidites à trois séismes instrumentaux : le séisme de Chengkong (12/10/2003) (Mw 6.8), le séisme de Taitung (11/24/1951) (Mw 7.1) et le séisme de Lutao (9/4/1935) (Mw 7.0). Au-delà du siècle dernier, les datations et modèles d’âges nous permettent d’établir une partie de la chronologie des évènements extrêmes sur une période de 3000 ans et d’estimer un temps de retour pour des évènements de l’ordre _Mw 7. Les résultats ont toutefois montré que ces temps de retour sont nettement supérieurs à ceux connus sur le siècle dernier, ce qui suggère que tous les séismes ne sont pas enregistrés par les dépôts sédimentaires marins. Ce travail de thèse a donc permis de montrer que les dépôts issus de la sédimentation évènementielle peuvent être considérés comme marqueurs de la sismicité et que cette approche peut constituer un outil complémentaire pour les études portant sur le risque sismique.
https://tel.archives-ouvertes.fr/tel-01661529

NNT : 2014MON20133
tel-01661529
https://tel.archives-ouvertes.fr/tel-01661529
https://tel.archives-ouvertes.fr/tel-01661529/document
https://tel.archives-ouvertes.fr/tel-01661529/file/55796_LEHU_2014_archivage_cor.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Hepatic drug transporters are now recognized as major actors of hepatobiliary elimination of drugs. Characterization of their regulatory pathways is therefore an important issue. In this context, the present study was designed to analyze the potential regulation of human hepatic transporter expression by protein kinase C (PKC) activation. Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48 h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells. The profile of hepatic transporter mRNA expression changes in PMA-treated HepaRG cells was correlated to that found in PMA-exposed primary human hepatocytes and was similarly observed in response to the PKC-activating marketed drug ingenol mebutate. It was associated with concomitant repression of OATP1B1 and OATP2B1 protein expression and reduction of OATP, OCT1, NTCP and MRP2 activity. The use of chemical PKC inhibitors further suggested a contribution of novel PKCs isoforms to PMA-mediated regulations of transporter mRNA expression. PMA was finally shown to cause epithelial-mesenchymal transition (EMT) in HepaRG cells and exposure to various additional EMT inducers, i.e., hepatocyte growth factor, tumor growth factor-β1 or the HNF4α inhibitor ≡I6015, led to transporter expression alterations highly correlated to those triggered by PMA. Taken together, these data highlight PKC-dependent regulation of human hepatic drug transporter expression, which may be closely linked to EMT triggered by PKC activation
ISSN: 0006-2952

hal-01216205
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01216205
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01216205/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01216205/file/Protein%20kinase%20C-dependent%20regulation.pdf
DOI : 10.1016/j.bcp.2015.10.007