Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the whole HIV population and in various risk groups over the next 10 years in France using a transmission dynamic compartmental model.Methods: The model was based on epidemiological data from the French Dat’AIDS cohort. Eight risk groups wereconsidered, including high-risk (HR) and low-risk (LR) men who have sex with men (MSM) and male/female heterosexuals,intra-venous drug users, or patients from other risk groups. The model was calibrated on prevalence and incidence dataobserved in the cohort between 2012 and 2015.Results: On January 1, 2016, 156,811 patients were registered as infected with HIV in France (24,900 undiagnosedpatients) of whom 7938 (5.1%) had detectable HCV-RNA (722 undiagnosed patients). Assuming a treatmentcoverage (TC) rate of 30%/year (i.e., the observed rate in 2015), model projections showed that HCV prevalenceamong HIV patients is expected to drop to 0.81% in 2026. Sub-analyses showed a similar decrease of HIV-HCVprevalence in most risk groups, including LR MSM. Due to higher infection and reinfection rates, predicted prevalencein HR MSM remained stable from 6.96% in 2016 to 6.34% in 2026. Increasing annual TC rate in HR MSM to 50/70%would decrease HCV prevalence in this group to 2.35/1.25% in 2026. With a 30% TC rate, undiagnosed patients wouldaccount for 34% of HCV infections in 2026.Conclusions: Our model suggests that DAA could nearly eliminate coinfection in France within 10 years for most riskgroups, including LR MSM. Elimination in HR MSM will require increased TC.
ISSN: 1741-7015

Droits : info:eu-repo/semantics/OpenAccess
inserm-01685739
http://www.hal.inserm.fr/inserm-01685739
http://www.hal.inserm.fr/inserm-01685739/document
http://www.hal.inserm.fr/inserm-01685739/file/2017%2C%20Virlogeux%20-%20Modeling%20HIV-HCV%20coinfection.pdf
DOI : 10.1186/s12916-017-0979-1

Éditeur(s) : HAL CCSD Elsevier [Commercial Publisher]
Résumé : International audience
BACKGROUND: Pneumocystis jiroveci pneumonia in HIV-negative immunocompromised patients is associated with high mortality rates. Although trimethoprim-sulfamethoxazole (TMP-SMX) provides a very effective prophylaxis, pneumocystosis still occurs and may even be emerging, due to sub-optimal characterization of patients most at risk, hence precluding targeted prophylaxis. METHODS: We retrospectively analyzed all cases of documented pneumocystosis in HIV-negative patients admitted in our institution, a referral center in the area, from January 1990 to June 2010, and extracted data on their underlying condition(s). To estimate incidence rates within each condition, we estimated the number of patients followed-up in our area for each condition, by measuring the number of patients admitted with the corresponding international classification diagnostic code, through the national hospital discharge database (PMSI). RESULTS: From 1990 to 2010, 293 cases of pneumocystosis were documented, of whom 154 (52.6%) tested negative for HIV. The main underlying conditions were hematological malignancies (32.5%), solid tumors (18.2%), inflammatory diseases (14.9%), solid organ transplant (12.3%), and vasculitis (9.7%). Estimated incidence rates could be ranked in three categories: i) high risk (incidence rates extgreater 45 cases per 100,000 patient-year): polyarteritis nodosa, granulomatosis with polyangiitis, polymyositis/dermatopolymyositis, acute leukemia, chronic lymphocytic leukemia, and non-Hodgkin lymphoma; ii) intermediate risk (25-45 cases per 100,000 patient-year): Waldenström macroglobulinemia, multiple myeloma, and central nervous system cancer; and iii) low risk ( extless 25 cases per 100,000 patient-year): other solid tumors, inflammatory diseases, and Hodgkin lymphoma. CONCLUSIONS: These estimates may be used as a guide to better target pneumocystosis prophylaxis in the groups most at risk.
ISSN: 0002-9343

hal-01063911
https://hal.archives-ouvertes.fr/hal-01063911
https://hal.archives-ouvertes.fr/hal-01063911/document
https://hal.archives-ouvertes.fr/hal-01063911/file/1-s2.0-S0002934314005907-main.pdf
DOI : 10.1016/j.amjmed.2014.07.010

Éditeur(s) : HAL CCSD
Résumé : International audience
Background: In French Guiana, a recent study has shown that a major part of the histoplasmosis incidence temporal fluctuations could be explained by climatic factors and thus postulated that disseminated histoplasmosis cases could be in a large proportion due to new infections. The description of the seasonal pattern of histoplasmosis could potentially help to test this new hypothesis. Patients and methods: A study using prospective data from the French Hospital Database for HIV was conducted in order to determine seasonal variations of the incidence of first cases of disseminated histoplasmosis in HIV persons in Cayenne, French Guiana. Single failure Cox proportional hazards models were used. Results: After adjusting for CD4 counts and antiretroviral treatment, the incidence of disseminated histoplasmosis was significantly higher during the Short Wet Season-Long Dry Season than during the Short Dry Season-Long Wet Season (Adjusted Hazard ratio 1.7 (1.1-2.5), P= 0.01). Conclusion: This result gives both valuable epidemiologic information to clinicians and a supplementary argument in favour of the hypothesis that an important proportion of cases were due to recent exposure. Therefore, the use of a primary prophylaxis must be discussed in French Guiana.
J AIDS Clinic Res

Droits : info:eu-repo/semantics/OpenAccess
inserm-00915009
http://www.hal.inserm.fr/inserm-00915009
http://www.hal.inserm.fr/inserm-00915009/document
http://www.hal.inserm.fr/inserm-00915009/file/2012_Hanf_-_Disseminated_Histoplasmosis_seasonal_incidence_variations_a_supplementary_argument_for_recent_infection.pdf
DOI : 10.4172/2155-6113.1000175

Éditeur(s) : Elsevier Science Bv
Résumé : Recent oceanographic surveys revealed the existence of five volcaniclastic deep-sea fans off La Reunion Island. The Cilaos fan is a large volcaniclastic submarine fan, connected to rivers that episodically experience torrential floods through a narrow and steep shelf-slope system. New piston cores presented in this study together with echosounder profiles give new insight into the evolution, of this extensive and sand-rich turbidite system. The Cilaos fan extends over 15,000 km(2) on an abyssal plain and is compartmentalized by topographic highs. Located southwest of the island, the sedimentary system consists of a canyon area and a deep sea fan divided into a proximal and a distal fan. The proximal fan is characterized by its wide extent and coarse-grained turbidites. The distal fan is characterized by elongated structures and fine-grained turbidites. A detailed morphological study of the fan which includes the analysis of swath bathymetry, backscatter, echosounder, and piston core data shows that the Cilaos fan is a complex volcaniclastic deep-sea fan, highly influenced by preexisting seafloor irregularities. The canyons and the slope area show a complex and evolving sediment feeding system with a direct sediment input by the river and irregular sediment supply by submarine landslide. Three main construction stages are identified for this system: (1) an old incision phase of the channels forming wide turbidites extending over the entire distal fan; (2) a period of no or low activity characterized by a thick layer of hemipelagic mud; and (3) a local reactivation of the channel in the proximal fan. Each stage seems to be linked to a different sediment source with a progressively increasing contribution of hemipelagic sediment and mud in younger stages. (C) 2011 Elsevier B.V. All rights reserved.
Marine Geology (0025-3227) (Elsevier Science Bv), 2011-10 , Vol. 288 , N. 1-4 , P. 1-17

Droits : 2011 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/00056/16704/14203.pdf
DOI:10.1016/j.margeo.2011.06.011
http://archimer.ifremer.fr/doc/00056/16704/

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
The natural history of pulmonary Langerhans cell histiocytosis (PLCH) has been unclear due to the absence of prospective studies. The rate of patients who experience an early progression of their disease is unknown. Additionally, conflicting effects of smoking cessation on the outcome of PLCH have been reported. In this prospective, multicentre study, 58 consecutive patients with newly diagnosed PLCH were comprehensively evaluated over a two-year period. Our objectives were to estimate the incidence of early progression of the disease and to evaluate the impact of smoking status on lung function outcomes. Lung function deterioration was defined as a decrease of at least 15% in FEV1 and/or FVC and/or DLCO, compared with baseline values. At each visit, smoking status was recorded based on the patients' self-reports and urinary cotinine measurements that were blinded for the patients. The cumulative incidence of lung function outcomes over time was estimated using the non-parametric Kaplan-Meier method. Multivariate Cox models with time-dependent covariates were used to calculate the hazards ratios of the lung function deterioration associated with smoking status with adjustment for potential confounders. The cumulative incidence of lung function deterioration at 24 months was 38% (22% for FEV1 and DLCO, and 9% for FVC). In the multivariate analysis, smoking status and PaO2 at inclusion were the only factors associated with the risk of lung function deterioration. The patients' smoking statuses markedly changed over time. Only 20% of the patients quit using tobacco for the entire study period. Nevertheless, being a non-smoker was associated with a decreased risk of subsequent lung function deterioration, even after adjustment for baseline predictive factors. By serial lung computed tomography, the extent of cystic lesions increased in only 11% of patients. Serial lung function evaluation on a three- to six-month basis is essential for the follow-up of patients with recently diagnosed PLCH to identify those who experience an early progression of their disease. These patients are highly addicted to tobacco, and robust efforts should be undertaken to include them in smoking cessation programs. ClinicalTrials.gov: No: NCT01225601 .
ISSN: 1750-1172

hal-01146047
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146047
PUBMED : 25887097
DOI : 10.1186/s13023-015-0249-2

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
On the Gulf of Lions margin, the Messinian Salinity Crisis (MSC) event led to a significant and widespread erosion of the Miocene shelf and slope. It is thus difficult nowadays to restore the morphology of the margin at the beginning of the crisis, and to study the Middle-Upper Miocene series rarely preserved from erosion. In this study, thanks to the use of multichannel seismic reflection data from the Gulf of Lions western slope, it has been possible to image the Miocene slope deposits. Interpretation of the data reveals several diachronic sediment bodies just beneath the Miocene/Pliocene boundary. These bodies are related to slope erosional-depositional complexes, underlain by erosional unconformities outlined by seismic reflector truncations. They are V- or U-shaped in cross section. Over their mapped extent, these bodies are typically 8-12 km wide and incise up to 600 ms TWTT into the Miocene slope deposits. in plan view, they are roughly elongated NW-SE, perpendicularly to the present day shelf break, and they progressively migrate towards the South-East. We interpret these seismic bodies as buried Miocene submarine canyons pre-dating the dramatic drawdown related to the MSC. In this study we try to constrain their age, and we discuss the events that may be at their origin. We also discuss the long-term impact of these slope canyons on the evolution of the margin.
ISSN: 0264-8172

hal-00411546
https://hal.archives-ouvertes.fr/hal-00411546
DOI : 10.1016/j.marpetgeo.2008.04.006

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Prostate cancer disparities have been reported in men of African descent who show the highest incidence, mortality, compared with other ethnic groups. Few studies have explored the genetic and environmental factors for prostate cancer in men of African ancestry. The glutathione-S-transferases family conjugates carcinogens before their excretion and is expressed in prostate tissue. This study addressed the role of GSTM1 and GSTT1 deletions on prostate cancer risk in populations of African descent. This multi-institutional case-control study gathered data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database, the African-Caribbean Cancer Consortium (AC3) and Men of African Descent and Carcinoma of the Prostate Consortium (MADCaP). The analysis included 10 studies (1715 cases and 2363 controls), five in African-Americans, three in African-Caribbean and two in African men. Both the GSTM1 and the GSTT1 deletions showed significant inverse associations with prostate cancer [odds ratio (OR): 0.90, 95% confidence interval (CI) 0.83-0.97 and OR 0.88, 95% CI: 0.82-0.96, respectively]. The association was restricted to Caribbean and African populations. A significant positive association was observed between GSTM1 deletion and prostate cancer in smokers in African-American studies (OR: 1.28, 95% CI: 1.01-1.56), whereas a reduced risk was observed in never-smokers (OR: 0.66, 95% CI: 0.46-0.95). The risk of prostate cancer increased across quartiles of pack-years among subjects carrying the deletion of GSTM1 but not among subjects carrying a functional GSTM1. Gene-environment interaction between smoking and GSTM1 may be involved in the etiology of prostate cancer in populations of African descent.
ISSN: 0143-3334

hal-00682901
https://hal.archives-ouvertes.fr/hal-00682901
DOI : 10.1093/carcin/bgr119
PUBMED : 21705483

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study aimed to compare the relative survival of patients with invasive breast cancer between women from French Guiana (a French territory in South America) and metropolitan France. No study hadever compared survival of breast cancer on the basis of immigrant status in France. Our study underlined that access to care for migrants is challenging whichwgenerates health inequalities. Background The prognosis of breast cancer in French Guiana is worse than in France with 23 deaths per 100 incident cases against 17 per 100 in metropolitan France. This study aimed to compare relative survival of patients with invasive breast cancer (IBC) between women from French Guiana and metropolitan France and to determine risk factors influencing breast cancer survival in French Guiana.Materials and methods Data were collected from the Cancer registry of French Guiana. We comparedthe relative survival of women with IBC between French Guiana and metropolitan France. We used Cox's proportional hazard regression to evaluate the effect of prognostic factors on cancer-specific mortality in French Guiana. Results We included all 269 cases of IBC in women diagnosed in French Guiana between 2003 and 2009. The overall 5-year relative survival rate of patients with IBC was 79% in French Guiana and 86% in metropolitan France. The place of birth (foreign country versus French territory), the tumor stage at the time of diagnosis, the mode of diagnosis (symptoms versus screening), the presence of hormone receptors in the tumor and the histologic type were the variables associated with survival differences. None of the other study variables were significantly associated with prognosis. Conclusion Access to care for migrants is challenging,which leads to health inequalities. Early detection through prevention programs is crucial to increaseIBC survival notably for foreign-born patients.
ISSN: 1526-8209

hal-01288657
https://hal.archives-ouvertes.fr/hal-01288657
https://hal.archives-ouvertes.fr/hal-01288657/document
https://hal.archives-ouvertes.fr/hal-01288657/file/2016%2C%20Roue%20-%20Predictive%20factors%20of%20the%20survival%20of%20women%20with%20invasive%20breast%20cancer%20in%20French%20Guiana.pdf

Éditeur(s) : HAL CCSD SAGE Publications
Résumé : International audience
: French Guiana is the French territory that is most affected by HIV. AIDS incidence is much higher than in mainland France and sex work seems to be an important driver of the epidemic. The objective of this study was to describe consistent condom use among female sex workers with their clients and their intimate partners and to identify determinants of non-use of condoms. An HIV/AIDS Knowledge, Attitudes, Behaviours and Practices survey was conducted in 2009-2010 among sex workers in French Guiana. A total of 477 sex workers were interviewed. Female sex workers were more likely to use condoms with their clients (97%) than with their intimate partners (45%). The factors associated with non-consistent condom use with the intimate partner were having had an abortion, feeling at risk for HIV, not evaluating one's own risk for HIV, living as a couple, being Dominican, not feeling comfortable asking intimate partners to use condoms. Although a high proportion of female sex workers declared using condoms with commercial partners, there is still room for improvement in the prevention of transmission with both commercial and intimate partners.
ISSN: 0956-4624

inserm-01065111
http://www.hal.inserm.fr/inserm-01065111
http://www.hal.inserm.fr/inserm-01065111/document
http://www.hal.inserm.fr/inserm-01065111/file/Table_III_IJSA.pdf
http://www.hal.inserm.fr/inserm-01065111/file/2014_Parriault_-_Predictive_factorssur unprotected_sex_for_female_sex_workers.pdf

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : The Maguelone shore extends along the northern coast of the Gulf of Lions margin, West of the Rhone delta and East of some high gradient coastal streams that have been providing most of the elastic sediments to the Gulf of Lions margin since the early Miocene. This 10 km wide area comprises an onshore small coastal watershed (15 km long) in low-lying carbonate hills, kilometer wide marshes, sandy beach and shoreface featuring local low sedimentation. Deposit architecture in such a coastal zone records dynamics of incised valley fill under the influence of rivers and wave/current hydrodynamics in a microtidal environment during an eustatic cycle.;A detailed analysis of about 250 km of very high resolution seismic profiles, tens of cores and outcrops data revealed the evolution of the Maguelone coastal system from Late-Quaternary to present-day. It highlighted also dominant denudation processes in the upstream catchments associated to the formation of incised valley seaward during Quaternary. Combination of this inherited morphology together with hydrodynamics controlled the lagoonal environment evolution since the last transgression. In particular, the Maguelone shore is characterized by the formation of built-over-rias lagoonal systems and records an evolution from partially protected lagoon to isolated lagoon environment. These two stages of lagoon evolution correspond to distinct deposit environments. Correlation of fauna contents with deposit geometry improves lagoonal environment models.
EISSN: 1777-5817

hal-00486370
https://hal.archives-ouvertes.fr/hal-00486370
DOI : 10.2113/gssgfbull.181.2.211

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Tropical cyclone (TC) waves can severely damage coral reefs. Models that predict where to find such damage (the 'damage zone') enable reef managers to: 1) target management responses after major TCs in near-real time to promote recovery at severely damaged sites; and 2) identify spatial patterns in historic TC exposure to explain habitat condition trajectories. For damage models to meet these needs, they must be valid for TCs of varying intensity, circulation size and duration. Here, we map damage zones for 46 TCs that crossed Australia's Great Barrier Reef from 1985–2015 using three models – including one we develop which extends the capability of the others. We ground truth model performance with field data of wave damage from seven TCs of varying characteristics. The model we develop (4MW) out-performed the other models at capturing all incidences of known damage. The next best performing model (AHF) both under-predicted and over-predicted damage for TCs of various types. 4MW and AHF produce strikingly different spatial and temporal patterns of damage potential when used to reconstruct past TCs from 1985–2015. The 4MW model greatly enhances both of the main capabilities TC damage models provide to managers, and is useful wherever TCs and coral reefs co-occur.
ISSN: 2045-2322

Droits : http://creativecommons.org/licenses/by/
hal-01330362
https://hal-univ-perp.archives-ouvertes.fr/hal-01330362
https://hal-univ-perp.archives-ouvertes.fr/hal-01330362/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01330362/file/srep26009.pdf
DOI : 10.1038/srep26009

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : Late Jurassic platform carbonates of Languedoc (southern France) are deeply incised by Late Miocene canyons, allowing the observation of karst systems filled with sediments containing evidences of marine origin. Field and structural relationships as well as new biostratigraphic data (planktonic foraminifera and calcareous nannofossils) provide a Latest Cretaceous-Earliest Paleocene age for the major karstification and a Paleocene (Danian-Selandian) age for the sedimentary filling. The ≥ 350 m vertical extent of this karst system and its subsequent marine filling gives a minimum amplitude for the base-level variation responsible for the karstification and then the marine flooding events. The observations suggest that at least, two marine successive events occurred in the Late Danian then in Selandian time. The large amplitude of base level is not in agreement with eustatic sea-level change, and the rate of base-level change is too fast for tectonic uplift and subsidence within the tabular, poorly deformed studied area. We propose a model of a silled endoreic basin, which was dessiccated and karstified over hundreds of meters, when it was disconnected from the World Ocean, and later suddently transgressed by the Paleocene sea and the karst flooded, when the bounding sill was submerged. Such a model is similar, although with significant differences, with the later Messinian-Zanclean event that affected the Mediterranean realm.
EISSN: 1777-5817

hal-00767556
https://hal.archives-ouvertes.fr/hal-00767556
DOI : 10.2113/gssgfbull.183.5.425

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Little is known of how linkage patterns between species change along environmental gradients. The small, spatially discrete food webs inhabiting tank-bromeliads provide an excellent opportunity to analyse patterns of community diversity and food-web topology (connectance, linkage density, nestedness) in relation to key environmental variables (habitat size, detrital resource, incident radiation) and predators: prey ratios. We sampled 365 bromeliads in a wide range of understorey environments in French Guiana and used gut contents of invertebrates to draw the corresponding 365 connectance webs. At the bromeliad scale, habitat size (water volume) determined the number of species that constitute food-web nodes, the proportion of predators, and food-web topology. The number of species as well as the proportion of predators within bromeliads declined from open to forested habitats, where the volume of water collected by bromeliads was generally lower because of rainfall interception by the canopy. A core group of microorganisms and generalist detritivores remained relatively constant across environments. This suggests that (i) a highly-connected core ensures food-web stability and key ecosystem functions across environments, and (ii) larger deviations in food-web structures can be expected following disturbance if detritivores share traits that determine responses to environmental changes. While linkage density and nestedness were lower in bromeliads in the forest than in open areas, experiments are needed to confirm a trend for lower food-web stability in the understorey of primary forests.
PLoS ONE

hal-00913931
https://hal.archives-ouvertes.fr/hal-00913931
https://hal.archives-ouvertes.fr/hal-00913931/document
DOI : 10.1371/journal.pone.0071735
OATAO : 10204

Éditeur(s) : HAL CCSD Universidad Complutense de Madrid
Résumé : Based on new seismological and recent faulting data, we analyze five main sectors in the western part of the Betic Cordillera from an active tectonic perspective: i. The northwestern frontal sector of the cordillera, including the Morón de la Frontera area, with shallow (< 15 km depth) seismogenic active NE-SW reverse and strike-slip faults that do not reach the surface. ii. The Teba area, in the External Zones, which is deformed by sparse N-S to NW-SE normal faults with associated wedges of Quaternary sediments and active strike-slip faults at intermediate crustal levels. iii. The Ronda Basin, representing the major Late Miocene intramontane basin of the western Betic Cordillera, is mainly deformed by NNE-SSW and WNW-ESE folds and locally by NW-SE normal faults. iv. The internal part of the orogen, which is characterized by shallow (<40 km) and intermediate (40 to 120 km depth) seismicity beneath Málaga and the Alborán Sea, ENE-WSW folding, relief uplift, river incision and scarce active faults with surface expression. v. The Spanish Atlantic coast, which coincides with the western end of the Betic orogen, where Pliocene to Quaternary shallowmarine sedimentary rocks are deformed by meso-scale NW-SE oriented normal faults and few ENE-WSW reverse faults. These data support the recent tectonic activity of the western Betic Cordillera determined by the NW-SE Eurasian-African convergence with variable features from the mountain front, characterized by shallow deformations, up to the Internal Zones that mainly undergo uplift and intermediate seismicity.
ISSN: 1698-6180

hal-00750359
https://hal.archives-ouvertes.fr/hal-00750359
DOI : 10.5209/rev_JIGE.2012.v38.n1.39211

Éditeur(s) : HAL CCSD
Résumé : International audience
To study the associations between occupation, industry and prostate cancer risk in Guadeloupe, a high incidence area. Incident cases of prostate cancer (707 cases) and 722 population controls were included. Information on lifetime occupational history and other potential risk factors was collected by interview. Logistic regression was used to estimate adjusted odds-ratios (OR) and their 95% confidence intervals (CI). A significantly decreased risk was observed in farmers (OR=0.5; CI 0.4-0.7), whereas marginally elevated ORs were found for farm workers, especially in sugarcane and banana farming. Banana plantation workers had been exposed to chlordecone, an estrogenic insecticide previously found to be associated with prostate cancer risk in this population. Significantly increased risks of prostate cancer were found in stock clerks (OR=2.7; CI 1.0-7.2), fishermen (OR=2.0; CI 1.0-4.0), mail distribution clerks (OR=7.7; CI 1.7-34.4) and electricians employed for more than 20 years (OR=4.0; CI 1.0-15.8), as well as in public administration (OR=1.8; CI 1.2-2.9), retail trade (OR=2.6; CI 1.1-6.0) and manufacture of food products (OR=2.0; CI 1.1-3.9), particularly sugar (OR=13.2; IC 1.6-108). Non-significantly elevated ORs were also seen for construction workers and transport equipment operators. Although the overall findings suggest that occupational factors have only a limited role in prostate cancer aetiology, elevated risks of prostate cancer were found in several occupations or industries. Exposure to pesticides, solvents, traffic-related air pollution, low physical activity, whole-body vibration may explain some of these increased risks.
Challenges for Occupational Epidemiology in the 21st Century EPICOH 2014
Chicago, United States

hal-01118558
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118558
DOI : 10.1136/oemed-2014-102362.312
PUBMED : 25018167

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : The role of the Karakorum fault zone (KFZ) is debated. South of 33°N, ongoing dextral-oblique slip along the SW edge of the Gar basin exhumes metamorphic and magmatic rocks of the Ayilari range. Minerals have recorded a continuum of deformation from temperatures >600–400°C down to <250_C. The 40Ar/39Ar ages, the oldest being 21.2 ± 1.0 Ma, yield minimum estimates for the initiation of the KFZ. These are in agreement with the U-Th/Pb ages constraining the onset of deformation at ca 25–22 Ma. Thermochronologic results show slow cooling for the period ca 21– 14 Ma, followed by rapid cooling between 14 and 4 Ma. These data demonstrate that right-lateral motion was in progress in the early Miocene and that shear continued at least until 4 Ma, pointing to >20 Ma of deformation along the fault. Greenschist facies deformation superimposed upon the medium- to high-grade deformation marks a kinematic change from pure dextral to dextral-normal motion associated with the onset of rapid cooling. At the regional scale, the coexistence of transtension in the Gar basin with transpression documented along the Pangong range farther north suggests another example of the ‘‘zipper tectonics'' model developed along the Red River fault. The kinematic shift induced the rise of the Ayilari range starting at 16–12 Ma and the incision of major river courses. The Indus River might have become captive of the relief at this time. The river's 120 km of apparent offset implies dextral motion at a long-term rate of ca 8.5 ± 1.5 mm/yr.
ISSN: 0278-7407

hal-00197561
https://hal.archives-ouvertes.fr/hal-00197561
https://hal.archives-ouvertes.fr/hal-00197561/document
https://hal.archives-ouvertes.fr/hal-00197561/file/Valli_Karakorum_thermochron_Tectonics_07_pre_print.pdf
DOI : 10.1029/2005TC001913

Éditeur(s) : Gauthier-Villars
Résumé : Holothuria atra is the most common aspidochirotid holothurian on tropical Indo-Pacific reefs, Asexual reproduction by transverse fission, followed by regeneration, has been studied at Reunion Island (Indian Ocean) and compared with different populations of the Indo-Pacific zone, thus permitting a better identification of the most significant parameters and a better understanding of this reproductive strategy. At Reunion Island, the species is studied at two stations on the same fringing reef: 1) on the back-reef where the fission rate is high (20 % of the population), the individuals small (generally weighting less than 150 g) and the population density high (4/m(2)); and 2) on the reef front, where fission is extremely rare, the mean size of the individuals larger (up to 300 g) and the density low (0.01/m(2)), Different categories of individuals, fissioning (F), after fission, anterior and posterior parts (A and P), and regenerating (Ap and Pa) have been identified from external observations. Dissection has demonstrated the unequal allocation of organs during fission and the variability of the regenerative states, mostly in the anterior part. Concerning fission, the position of the split in an individual is in the anterior half (at 44 % of the total length). The monthly incidence of fission is higher from October to January and in June-July. Fission does not result in an increase in the density of the population. The monthly rates of regenerating individuals originating from anterior (3.7 %) and posterior (5.1 %) parts suggest that survival is higher in the latter instance. The occurrence of asexual reproduction in various populations of this species is discussed in relation to the ecology and the parameters of the populations considered. On the back-reef studied at Reunion Island, the population is subtidal and emersion cannot explain fission. Anthropogenic disturbances are possible triggers of this phenomenon.
Oceanologica Acta (0399-1784) (Gauthier-Villars), 1996 , Vol. 19 , N. 3-4 , P. 209-216

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00094/20479/18149.pdf
http://archimer.ifremer.fr/doc/00094/20479/

Éditeur(s) : HAL CCSD American Society for Microbiology
Résumé : International audience
Toxoplasmosis is a life-threatening infection in immunocompromised patients (ICPs). The definite diagnosis relies on parasite DNA detection, but the incidence and burden of disease are ill-known in HIV-negative patients. A three-year retrospective study was conducted in 15 reference laboratories from the network of the French National Reference Center for Toxoplasmosis, to record the frequency of Toxoplasma DNA detection in ICPs, to review the molecular methods used for diagnosis and the prevention measures implemented in transplant patients. During the study period, out of 31,640 PCR performed in ICPs, 610 were positive (323 patients). Blood (n=337), cerebrospinal fluid (n=101) and aqueous humor (n=100) samples were more frequently positive. Chemoprophylaxis schemes in transplant patients differed between centers. PCR follow-up of allogeneic hematopoietic stem-cell transplant (allo-HSCT) patients was implemented in 8/15 centers. Data from 180 patients (13 centers) were further analyzed regarding clinical setting and outcome. Only 68/180 (38%) patients were HIV+; the remaining 62% consisted in 72 HSCT, 14 solid-organ transplants, and 26 miscellaneous immunodeficiencies. Cerebral toxoplasmosis and disseminated toxoplasmosis were most frequently observed in HIV and transplant patients, respectively. Of 72 allo-HSCT patients with a positive PCR, 23 were asymptomatic; all were diagnosed in centers performing systematic blood PCR follow-up, and received specific treatment. Overall survival of allo-HSCT patients at two months was better in centers with PCR follow-up than in other centers (p<0.01). This study provides updated data on the frequency of toxoplasmosis in HIV-negative ICPs and suggests that regular PCR follow-up of allo-HSCT patients could guide pre-emptive treatment and improve outcome.
ISSN: 0095-1137

hal-01134189
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134189
DOI : 10.1128/JCM.03282-14
PUBMED : 25762774

Éditeur(s) : HAL CCSD
Résumé : In order to identify and quantify the Rif (Morocco) present-day deformation, especially those related to active faults (location, geometry, kinematic), we perform a morphotectonic study. The studied area and faults are located in the Northern part (conjugate faults of Al-Hoceima Bay: Trougout, Boujibar and Rouadi), the Eastern part (Nekor fault) and the Southern part of the chain (Rif frontal thrust between Fes and Meknes cities).Morphotectonic tools (DEMs at different scales, satellite and aerial pictures), field studies and Quaternary dating methods (U/Th, OSL, 14C and in-situ cosmogenic isotopes 10Be, 3He, 36Cl) allow us to characterize transtensional deformation in the Northern Rif. Horizontal and vertical slip rates along the N-S-oriented Trougout major fault are ~1.6 mm/yr and ~2 mm/yr respectively. In the Southern part, the Rif frontal thrust shows a shortening rate of ~1.8 mm/yr into Fes and Meknes area. In the Eastern part, the deformation is focused on the Nekor left-lateral strike-slip major fault with ~1.5 mm/yr. Incision features and raised marine terraces involve an uplift of the chain about ~0.2 mm/yr. The overall deformation in the Rif seems to be continuous since the Messinian-Pliocene time.These new morphotectonic constraints are consistent with the GPS measurements showing southwestward overall motion of most of the Rif belt with respect to stable Africa, associated to clockwise rotation. Finally, we propose a geodynamic model in which the Rif, the Alboran sea and the Betics belong to a single microplate bounded by the strike-slip faults of the Betics on the North, the Rif frontal thrust on the South, the Nekor and TASZ (Trans Alboran Shear Zone) strike-slip faults on the East and North-East, and the western Rif folded structures on the West.
L'objectif de cette étude est d'identifier et de quantifier les déformations actuelles dans la chaine du Rif (Maroc), notamment celles associées aux failles actives (localisation, géométrie, cinématique). Pour ce faire, nous mettons en œuvre pour la première fois dans cette région, une approche morphotectonique. Les sites et failles sélectionnés et étudiés se situent dans la partie Nord (les failles conjuguées de la baie d'Al-Hoceima: Trougout, Boujibar et Rouadi), l'Est (la faille de Nékor) et le Sud (front chevauchant sud rifain entre Fes et Meknes).A partir des outils de la morphotectonique (MNTs à différentes résolutions, images satellitaires, photographies aériennes), d'analyses de terrain et grâce aux méthodes de datation du Quaternaire (U/Th, OSL, 14C et isotopes cosmogéniques produits in-situ 10Be, 3He, 36Cl), cette étude met en évidence et quantifie une déformation transtensive dans la partie Nord de la chaine. Les vitesses de glissement horizontales et verticales le long de la faille principale d'orientation méridienne de Trougout sont de ~1.6 mm/an et ~2 mm/an, respectivement. Dans la partie Sud, nous montrons que le front rifain entre Fez et Meknes est actif avec une vitesse de raccourcissement de ~1.8 mm/an. La déformation dans la région Est se localise principalement sur la faille du Nékor avec une vitesse décrochante senestre de ~1.5 mm/an. Par ailleurs, la présence de nombreuses figures d'incision et de surfaces marines soulevées au niveau du littoral Nord témoignent d'une surrection généralisée de la chaine de l'ordre de ~0.2 mm/an. L'ensemble de cette déformation semble être constante depuis la période du Messino-Pliocène. Ces résultats sont cohérents avec les données GPS qui montrent un déplacement de ~5mm/an vers le SW de l'ensemble du Rif associé à un mouvement rotatif horaire, dans le référentiel Afrique stable. D'un point de vue géodynamique, nous proposons que le Rif, la mer d'Alboran et les Bétiques appartiennent à une même microplaque limitée au Nord par les failles décrochantes des Bétiques, au Sud par le chevauchement rifain, à l'Est et au Nord-Est par les failles décrochantes de Nékor et de la TASZ (Trans Alboran Shear Zone) et à l'Ouest par les structures plissées bordières du Rif.
https://tel.archives-ouvertes.fr/tel-01170466

NNT : 2014MON20105
tel-01170466
https://tel.archives-ouvertes.fr/tel-01170466
https://tel.archives-ouvertes.fr/tel-01170466v2/document
https://tel.archives-ouvertes.fr/tel-01170466/file/41875_POUJOL_2014_archivage_cor.pdf

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
Absolute Mα x-ray production cross sections have been measured and calculated for heavy elements Au, Pb, Bi, and U for electron incident energies from the ionization threshold up to 38 keV. The experimental cross sections were deduced from M x-ray intensities emitted from ultrathin samples of the elements of interest deposited onto self-supporting C films. The measurements were performed using two electron microprobes and several wavelength-dispersive spectrometers. X-ray intensities were converted into x-ray production cross sections by using estimated values of the number of incident electrons, target thickness, and spectrometer efficiency. Experimental results are compared with calculated cross sections using different predictive formulae. Good agreement is found between the measured cross sections and the predictions from the distorted-wave Born approximation, which indicates that this approximation is suited for the calculation of M-shell ionization cross sections of heavy elements.
ISSN: 0142-2421

hal-01122839
https://hal.archives-ouvertes.fr/hal-01122839
DOI : 10.1002/sia.5561