Éditeur(s) : HAL CCSD
Résumé : International audience
Selective serotonin reuptake inhibitor medications (SSRIs) are the first lines of treatment for maternal affective disorders, and are prescribed to up to 10% of pregnant women. Concern has been raised about how perinatal exposure to these medications affect offspring neurobehavioral outcomes, particularly those related to social interactions, as recent research has reported conflicting results related to autism spectrum disorder (ASD) risk in children prenatally exposed to SSRIs. Therefore, the aim of this work was to investigate the effects of perinatal exposure to the SSRI fluoxetine on social play behaviors and the hypothalamic pituitary adrenal system, using a model of pre-gestational maternal stress. We also investigated synaptic proteins in the CA2, CA3, and dentate gyrus of the hippocampus, as well as number of immature neurons in the granule cell layer, as both measures of plasticity in the hippocampus have been linked to social behaviors. In pre-adolescent male and female Sprague-Dawley rat offspring, main findings show that perinatal fluoxetine prevents the negative effect of maternal stress on sibling play behavior. However, perinatal fluoxetine increased social aggressive play with a novel conspecific in both sexes and decreased time grooming a novel conspecific in males only. Perinatal fluoxetine also increased serum corticosteroid binding globulin levels, 5-HT levels in the hippocampus, and pre-synaptic density assessed via synaptophysin in the dentate gyrus. Social interaction was significantly correlated with changes in plasticity in the CA2 region of the hippocampus. Pre-gestational maternal stress exposure resulted in significantly decreased rates of hippocampal neurogenesis and synaptophysin density in the dentate gyrus of pre-adolescent males, but not females. Together, these results further characterize the role of perinatal SSRIs, maternal stress prior to conception, and sex/gender on developing social behaviors and related plasticity in the hippocampus of pre-adolescent offspring.
Psychoneuroendocrinology

hal-01579611
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579611
DOI : 10.1016/j.psyneuen.2017.07.480
PUBMED : 28735226

Éditeur(s) : HAL CCSD John Wiley & Sons
Résumé : International audience
Kisspeptins are now considered key players in the neuroendocrine control of puberty and reproduction, at least in mammals. Most teleosts have two kiss genes, kiss1 and kiss2, but their sites of expression are still poorly documented. As a first step in investigating the role of kisspeptins in the European sea bass, a perciform fish, we studied the distribution of kiss1 and kiss2-expressing cells in the brain of males and females undergoing their first sexual maturation. Animals were examined at early and late in the reproductive season. We also examined the putative expression of estrogen receptors in kiss-expressing cells and, finally, we investigated whether kisspeptins are expressed in the pituitary gland. We show that kiss1-expressing cells were consistently detected in the habenula and, in mature males and females, in the rostral mediobasal hypothalamus. In both sexes, kiss2-expressing cells were consistently detected at the level of the preoptic area, but the main kiss2 mRNA-positive population was observed in the dorsal hypothalamus, above and under the lateral recess. No obvious sexual differences in kiss1 and kiss2 mRNA expression were detected. Additional studies based on confocal imaging clearly showed that most kiss1 mRNA-containing cells of the mediobasal hypothalamus strongly express ERα and slightly express ERβ2. At the pituitary level, both sexes exhibited kiss1 mRNA expression in most FSHβ-positive cells and never in LHβ-positive cells.
ISSN: 0092-7317

hal-00877326
https://hal.archives-ouvertes.fr/hal-00877326
PUBMED : 22886357
DOI : 10.1002/cne.23211

Résumé : Spiny lobsters are an important component of the coastal fisheries around the Martinique island. This study aimed to assess the contamination by kepone of the two main species Panulirus argus and P. guttatus in the main fishery area laying along the eastern coast of Martinique. The objectives of the study were to describe the distribution of the spiny lobster contamination in the area, to explore possible relationships with some biological parameters such as individual size, sex and colour of tegument, as well as characterize difference of kepone concentration between the muscle and soft flesh of the head, in view of helping the definition of further fishery management measures. The analyses were done from chemical analyses of 125 samples of spiny lobsters gathered from 2008 to 2010 all around the island, and from a specific set of 200 new observations from a specific survey carried out in 2011 in the study area. For both species, the results show a diffusion of the contamination all over the coral shoals, close to contaminated catchment basins, with a strong decrease just outside these areas. For the Caribbean spiny lobster, a strong relationship between kepone concentration and individual size was identified, and less for the Spotted spiny lobster. For the two species, the concentration of kepone found in soft flesh of the head was more than twice as in the muscle. Finally, the difference of contamination between the two species appeared strongly linked with their biology.
La langouste blanche Panulirus argus et la langouste brésilienne P. guttatus représentent environ 25 % du chiffre d’affaires des pêcheurs professionnels de Martinique. Une part très importante des captures de ces espèces proviennent du platier continental de la zone centre-atlantique de l’île. L’étude réalisée en 2011 visait à approfondir les connaissances sur la distribution de la contamination par la chlordécone des langoustes dans la zone centre- atlantique de la Martinique, d’explorer d’éventuelles relations entre cette contamination et des paramètres biologiques des individus comme la taille, le sexe et leur pigmentation tégumentaire, et d’analyser la différence de contamination entre la queue et les chairs molles du céphalothorax, en vue d’aider à la définition de mesures de réglementation de la pêche dans ce secteur. L’étude s’appuie sur un ensemble de 125 échantillons rassemblés de 2008 à 2010 pour les deux espèces autour de la Martinique, complétés par 200 échantillons constitués pour la présente étude dans la zone centre-atlantique en 2011. Le rapport est précédé d’un rappel d’éléments sur la biologie et sur l’état de la pêche des langoustes en Martinique. Pour les deux espèces, l’étude met en évidence une extension de la contamination à l’ensemble du platier corallien au pied des bassins versants contaminés, puis une nette diminution au-delà. Pour la langouste blanche, cette contamination est en relation avec la taille des individus, en liaison avec leur plongée progressive vers le large. Cette relation avec la taille est moins marquée pour la langouste brésilienne, espèce beaucoup plus inféodée aux eaux littorales. Pour les deux espèces, les chairs molles du céphalothorax apparaissent plus de deux fois plus contaminées que le muscle caudal. Les différences de contamination observées entre langouste blanche et la langouste brésilienne sont cohérentes avec les connaissances sur la biologie de chaque espèce.

Droits : Délégation Antilles
http://archimer.ifremer.fr/doc/00088/19971/17638.pdf
http://archimer.ifremer.fr/doc/00088/19971/

Éditeur(s) : EDP Sciences
Résumé : Daily growth increments measured in the otolith of Thunnus atlanticus were used to estimate the age and growth of individuals. which were sampled from an artisanal fishery operating around fish aggregating devices (FADs) moored off Martinique Island. In this study, 76 otoliths were analysed for fish ranging from 20 to 68 cm fork lengths (FL). The fish were caught using trolling lines at depths ranging from 0 to 10 m. Counts were made, under a light microscope, on the external part of the transverse section of the sagittae, from the primordium to the ventral edge. The mean coefficient of variation of the age reading was 2.4%. To validate readings, the number of increments for 11 individuals was counted using both optic and scanning electron microscopes. The calculated relationship between readings of both methods was found to be linear, with a slope of 1.03 and R-2 = 0.99. Frequency of growth increment formation could not be validated. Growth rates derived from otolith readings were, however, compared to those obtained using a modal progression analysis, which was performed on the length-frequency distributions of the landings over a period of two months. The corroboration between the growth rates was good. One increment was assumed to represent one day. The parameters of the von Bertalanffy growth curve for both sexes were L-infinity = 71.4 cm FL, k = 0.002 day(-1) and tau(0) = -80 days. According to our results, there is no evidence that Martinican moored FADs act as ecological traps for blackfin tuna. Instead, young blackfin tuna probably leave the vicinity of Martinican moored FADs to undergo a trophic migration at 7 to 8 month-old, and then come back about 8 months later to breed in the Lesser Antilles area.
Les microstructures présentes dans les otolithes de Thunnus atlanticus ont été utilisées pour estimer l'âge et la croissance des thons capturés par la pêcherie artisanale exploitant les dispositifs de concentrations de poissons (DCP) mouillés autour de la Martinique. Des thons de 20 à 68 cm de longueur à la fourche (LF) ont été capturés à la ligne de traîne de surface entre 0 et 10 m de profondeur. Les stries d'accroissement ont été comptées sur 76 otolithes en microscopie optique sur la partie externe des coupes transversales de la sagitta, du nucléus jusqu'à l'extrémité verticale de la coupe (coefficient de variations 2,4 %). Afin de vérifier qu'il n'y avait pas de sous-estimation du nombre de stries, nous avons effectué un comptage, en microscopie électronique à balayage, pour 11 individus. La relation établie entre ces deux méthodes de comptage est linéaire avec un pente égale à 1,03 et R2 = 0,99. La vitesse de croissance issue de l'analyse des otolithes a été comparée à celle estimée à partir de l'analyse en progression modale des distributions en fréquence de taille des débarquements sur une période de 2 mois. La corroboration entre les deux méthodes était bonne. Nous avons supposé que la formation des stries de croissance suivait un rythme journalier. Les paramètres de l'équation de croissance de von Bertalanffy pour les 2 sexes confondus sont: L-infinity = 71.4 cm FL, k = 0.002 day(-1) and tau(0) = -80 days. Les résultats de cette étude n'indiquent pas que les DCP ancrés martiniquais puissent agir comme des pièges écologiques pour les thons noirs. Les jeunes thons noirs semblent au contraire quitter la proximité des DCP et entreprendre une migration trophique lorsqu'ils atteignent 7 à 8 mois. Ils ne reviendraient ensuite dans la zone des Petites Antilles qu'environ 8 mois plus tard, manifestement pour se reproduire.
Aquatic Living Resources (0990-7440) (EDP Sciences), 2004 , Vol. 17 , N. 1 , P. 13-18

Droits : EDP Sciences, IFREMER, IRD 2004
http://archimer.ifremer.fr/doc/2004/publication-396.pdf
DOI:10.1051/alr:2004009
http://archimer.ifremer.fr/doc/00000/396/

Résumé : Bycatch of marine turtles, vulnerable or endangered species, is a growing issue of all fisheries, including Oceanic purse-seine fishery. The present paper seeks to assess marine turtle bycatch at a spatial and temporal level in the European purse seine fishery operating in the Atlantic and Indian Oceans. The study was based on data collected through French and Spanish observer programs from 1995 to 2011, a period where more than 230 000 fishing sets were realized by the UE fleets in both Oceans. A total of 15 913 fishing sets were observed, including 6 515 on drifting Fish Aggregate Devices (FAD) and 9 398 on Free Swimming Schools (FSC). Over the study period, 597 turtles were caught, 86% being released alive at sea. At the same time, from 2003 to 2011, 14 124 specific observations were carried out on floating objects whether they ended in a set or not. 354 marine turtles were observed upon which 80% were already free or entangled alive and therefore released alive. At the temporal and spatial level, data were organized and analysed by Ocean, fishing mode (FAD vs. FSC) as well as by year, quarter and statistical square of 1°. In order to evaluate the impact if this fishery in both Oceans, bycatch distribution was compared to the total fishing effort of the UE fleet, as well as to the known marine turtle post nesting migration routes, nesting population abundances and known feeding areas. The species composition, the size and sex structure of bycatch are also discussed here. At last, an attempt to raise the data to the total fishing effort was carried out. Based on observation of marine turtle by-catches on sets, we estimated that, globally, 3500 marine turtles were accidentally captured by the EU-PS fleet in the Atlantic Ocean from 1995 to 2010, and around 2000 in the Indian Ocean from 2003 to 2010, with a corresponding annual bycatch rate of 218 (SD=150; survival rate =91%) and 250 (SD=157; survival rate =77%) respectively in the Atlantic and Indian Ocean. However, because of important uncertainties mainly due to the low observation coverage and the scarcity of marine turtle bycatch events, it was impossible to produce solid and reliable global estimates of marine turtle bycatch and mortality due to PS activity.

Droits : 2012 IOTC
http://archimer.ifremer.fr/doc/00149/25991/24087.pdf
http://archimer.ifremer.fr/doc/00149/25991/

Éditeur(s) : HAL CCSD
Résumé : Cet article étudie la distribution des moyennes générales annuelles et des moyennes annuelles en EPS, mathématiques, français, histoire-géographie et philosophie selon le sexe et l'orientation de genre de 499 lycéens et lycéennes. Ces derniers fréquentent un établissement obtenant de forts taux de réussite au baccalauréat général et se caractérisant par une population composée d'élèves provenant plutôt des classes favorisées que des milieux populaires. Nos résultats montrent que les élèves qui possèdent les traits "masculins", qu'ils soient garçons ou filles, réussissent globalement mieux que leurs camarades. Ainsi, les traits "masculins" seraient scolairement plus rentables dans cet établissement.
https://hal.archives-ouvertes.fr/hal-01446074

hal-01446074
https://hal.archives-ouvertes.fr/hal-01446074
https://hal.archives-ouvertes.fr/hal-01446074/document
https://hal.archives-ouvertes.fr/hal-01446074/file/Genre_discpilines_Moniotte_Poggi.pdf

Éditeur(s) : HAL CCSD L'Harmattan
Résumé : A partir des dossiers personnels de la sous-série 4C des Archives Nationales du Sénégal en établissant des statistiques à partir des 96 coopérants nés en Martinique, en Guadeloupe ou en Guyane, cette liste n'étant pas exhaustive, cet article esquisse un profil de ces coopérants, en identifiant leurs départements d'origine, leur sexe et leurs professions; les sociabilités et modes de vie du " cercle " des coopérants antillais à Dakar.
Cahiers Afrique

Droits : info:eu-repo/semantics/OpenAccess
hal-00974142
https://hal.univ-antilles.fr/hal-00974142
https://hal.univ-antilles.fr/hal-00974142/document
https://hal.univ-antilles.fr/hal-00974142/file/Cahiers-Afrique-28-Labrune-Badiane.pdf

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The six-minute walk test is a well-established submaximal exercise reflecting the functional status and the clinical severity of sickle cell patients. The aim of the present cross-sectional study was to investigate the biological determinants of the six-minute walk test performance in children with sickle cell anemia. Hematological and hemorheological parameters, pulmonary function and the six-minute walk test performance were determined in 42 children with sickle cell anemia at steady state. The performance during the six-minute walk test was normalized for age, sex and height and expressed as percentage of the predicted six-minute walk distance. We showed that a high level of anemia, a low fetal hemoglobin expression and low red blood cell deformability were independent predictors of a low six-minute walk test performance. This study describes for the first time the impact of blood rheology in the six-minute walk test performance in children with sickle cell anemia.
ISSN: 1932-6203

inserm-00922110
http://www.hal.inserm.fr/inserm-00922110
http://www.hal.inserm.fr/inserm-00922110/document
http://www.hal.inserm.fr/inserm-00922110/file/2013_Waltz_-_Hematological_and_hemorheological_determinants_6_minutes.pdf
DOI : 10.1371/journal.pone.0077830

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period, questions have been raised about the longterm impact of these medications on development. We aimed to investigate how developmental SSRI exposure may alter affect-related behaviors and associated molecular processes in offspring using a rodent model of maternal stress and depression. For this purpose, prenatally stressed or non-stressed male offspring were exposed to fluoxetine (5 mg/kg/day) or vehicle, via lactation, until weaning. Primary results show that postnatal fluoxetine exposure differentially altered anxiety-like behavior by increasing anxiety in non-stressed offspring and decreasing anxiety in prenatally stressed offspring. In the hippocampus, developmental fluoxetine exposure decreased BDNF IV and TrkB mRNA expression. Prenatal stress alone also decreased escape behaviors and decreased hippocampal BDNF IV mRNA expression. These data provide important evidence for the long-term programming effects of early-life exposure to SSRIs on brain and behavior.
ISSN: 0012-1630

hal-01305478
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01305478
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01305478/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01305478/file/Developmental%20SSRIs%2C%20anxiety%20and%20BDNF_accepted.pdf
DOI : 10.1002/dev.21385

Éditeur(s) : HAL CCSD Inter-Research
Résumé : International audience
Sphaeroma serratum is a marine isopod species that inhabits seashores from Europe to West Africa. The individuals live under stones in direct contact with reduced sediments and harbour a diverse bacterial community on the cuticle of their pleopods. We investigated the diversity of these epibiotic bacteria on male (pubescent and senescent) and female specimens with electron microscopic obser vations and molecular tools. The microbial community of S. serratum was shown to be composed of at least 5 bacterial morphotypes observed on the pleopodal cuticle in all male specimens. Using fluorescence in situ hybridization, we identified 5 major phylogenetic groups (α-, β-, γ- and δ-Proteobacteria and Archaea) whereas denaturing gradient gel electro - phoresis (DGGE) of PCR-amplified 16S rRNA gene fragments of epibiotic bacteria revealed 50 bands. The bacterial community associated with S. serratum seems more diverse than in other marine crustaceans, such as Rimicaris. The relative diversity of this bacterial community was also studied in relation to the molt cycle. The comparison of DGGE band patterns of several individuals from female, pubescent male and senescent male groups revealed that the bacterial community diversity was dependent on the sex and the age of the individuals and more generally on the molt status.
Marine Ecology Progress Series

hal-00743743
https://hal.univ-antilles.fr/hal-00743743
DOI : 10.3354/meps09711

Résumé : L'objectif du registre des cancers de Guyane est de collecter l ensemble des tumeurs invasives et/ou in situ survenues depuis le 1er janvier 2003 chez des patients vivant en Guyane, quels que soient la localisation de la tumeur, le lieu de diagnostic et de traitement. Cette thèse a pour but de décrire la population atteinte d un cancer afin d améliorer les connaissances sur cette maladie et ainsi de permettre aux actions de santé publique d être plus efficaces.De 2003 à 2009, le taux d incidence des cancers standardisé sur l âge était, dans les deux sexes, 30% inférieur en Guyane par rapport à la France métropolitaine et n était pas différent de celui d Amérique du Sud.Nous avons comparé l incidence, la mortalité et la survie relative des patientes atteintes d un cancer invasif du sein (CIS) et des patientes atteintes d un cancer invasif du col de l utérus (CIC) entre la Guyane et la métropole.Le ratio incidence/mortalité indiquait que les cancers du sein étaient de plus mauvais pronostic en Guyane par rapport à la métropole.La survie relative des femmes atteintes d un CIS était inférieure en Guyane par rapport à la France métropolitaine.En Guyane, le taux standardisé d incidence du cancer du col de l utérus était 4 fois plus élevé qu en métropole. Les femmes vivant dans l intérieur de la Guyane semblaient être diagnostiquées à un stade plus tardif et plus souvent sur symptômes que les femmes du littoral. L accès aux soins des migrants est un challenge et une source d inégalité de santé. La détection précoce des cancers à travers des programmes de prévention est cruciale pour améliorer la survie par cancer et notamment chez les patients étrangers.
The objective of the cancer registry of French Guiana is to compile all patients living in French Guiana with malignant invasive pathology and/or in situ lesions starting January 1st 2003 in persons living in French Guiana, whatever the tumoral location and the place of diagnosis and care. This study aimed to describe the population with invasive cancer to improve the knowledge about this disease in order to target public health interventions more effectively.The age standardised incidence rate was 30% times lower than in France in both sexes and the same than in South America.We compared incidence and relative survival of patients with invasive breast cancer (IBC) and patients with invasive cervical cancer (ICC) between women from French Guiana and metropolitan France.The ratio between incidence and mortality showed that the prognosis of IBC in French Guiana was worse than in metropolitan France.The relative survival rate among women with IBC in French Guiana was lower than among women in metropolitan France.In French Guiana, the age-standardized incidence rate of cervical cancer was four times higher than in France. Women living in remote areas seemed to be diagnosed later and more often following symptoms.Access to care for migrants is challenging and sustains health inequalities. Early detection through prevention programs is crucial for increasing cancer survival notably for foreign-born patients. Further studies with more patients and other variables could improve the knowledge about these diseases

http://www.theses.fr/2014AGUY0743/document

Éditeur(s) : HAL CCSD
Résumé : International audience
Handball scolaire pour les filles en EPS. Quels risques d'inégalités ? MP. Poggi Poggi, M.-P. (2016). Handball scolaire pour les filles en EPS. Quels risques d'inégalités ? In J.-F. Gréhaigne (Ed.), Les objets de la technique. De la compétence motrice à la tactique individuelle (pp. 250-266). Besançon : PUFC. Introduction Le « 18 décembre 2011, l'équipe de France féminine de handball a joué et perdu la finale du mondial dans une relative indifférence. Il faut dire que ce sport rapporte peu, et que des femmes sont en compétition » écrit le directeur de l'Observatoire des inégalités, Louis Maurin. Le spectacle souffre d'un double déficit attractif : discipline sportive « mineure », qui plus est pratiquée par des femmes, deux facteurs qui suffisent à éloigner les projecteurs et à minimiser considérablement la portée de l'événement. Du coup, le handball féminin ne fait pas recette à la télévision. Pourtant, dans cette fédération qui compte plus de 500 000 licenciés, un sur trois (36,5%) est une femme, ce qui, parmi les sports collectifs, ne la place pas au dernier rang du point de vue de la parité entre les sexes (fédération française de football 4,5%, fédération française de rugby 4,9%, fédération française de basketball 38,3%, fédération française de volleyball 48,1%). On observe une inégale reconnaissance des formes de la pratique avec une partition nette entre d'un côté, un modèle masculin surexposé médiatiquement, et de l'autre, son corollaire féminin confiné à la confidentialité. Cette position hégémonique occupée par le handball masculin contribue à l'ériger au statut de référence incontournable dans le monde sportif. Qu'en est-il en milieu scolaire ? L'école sert-elle de courroie de transmission du maintien de ces rapports sociaux de sexe ? Lequel des deux modèles, féminin ou masculin, l'école veut-elle retenir comme référence pour définir les contenus à étudier et à apprendre ? Qu'est-ce qui va mériter d'être enseigné et être désigné
Les objets de la technique. De la compétence motrice à la tactique individuelle

hal-01620919
https://hal.univ-antilles.fr/hal-01620919
https://hal.univ-antilles.fr/hal-01620919/document
https://hal.univ-antilles.fr/hal-01620919/file/2016%20HB%20scolaire%20pour%20les%20filles%20in%20JFG.pdf

Éditeur(s) : Edp Sciences S A
Résumé : This study was designed to measure responses of four-year-old black-lip pearl oysters (Pinctada margaritifera) to different temperatures and food concentrations and to identify the energy requirements of each sex. Oysters were fed a monospecific microalgal diet of Isochrysis affinis galbana (T-iso). Measurements of oxygen consumption and ingestion rates were carried out at 24 degrees C and 27 degrees C and at two algal (T-iso) concentrations: 5000 and 30 000 cell ml(-1). Glycogen content in adductor muscle, absorption efficiency and scope for growth were also estimated. Females and males responded differently to environmental factors, with food level being the most influential parameter. Oxygen consumption and absorption efficiency were significantly higher in females than in males, but males had significantly higher glycogen content than females. At high food concentration, glycogen content, ingestion rate, oxygen consumption, and scope for growth were significantly higher than at the low food concentration. Only absorption efficiency was significantly higher at the low food concentration. Oxygen consumption was significantly higher at 27 degrees C than at 24 degrees C. These results indicate that females and males have different bioenergetic functioning and that energy demands for reproduction are higher in females.
Aquatic Living Resources (0990-7440) (Edp Sciences S A), 2013-07 , Vol. 26 , N. 3 , P. 263-271

Droits : EDP Sciences, IFREMER, IRD 2013
http://archimer.ifremer.fr/doc/00157/26855/24980.pdf
DOI:10.1051/alr/2013059
http://archimer.ifremer.fr/doc/00157/26855/

Éditeur(s) : HAL CCSD Seismological Society of America
Résumé : Shear-wave splitting measurements are widely used to analyze orientations of anisotropy. We compare two different shear-wave splitting techniques, which are generally assumed to give similar results. Using a synthetic test, which covers the whole backazimuthal range, we find characteristic differences, however, in fast-axis and delay-time estimates near Null directions between the rotation correlation and the minimum energy method. We show how this difference can be used to identify Null measurements and to determine the quality of the result. This technique is then applied to teleseismic events recorded at station LVZ in northern Scandinavia, for which our method constrains the fast-axis azimuth to be 15° and the delay time 1.1 sec.
ISSN: 0037-1106

hal-00404493
https://hal.archives-ouvertes.fr/hal-00404493
DOI : 10.1785/0120060190

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : International audience
Au siècle dernier, plus exactement en avril 1995, la revue médecine/sciences consacrait pour la première fois un de ses numéros au testicule. Dix sept ans plus tard, le saut du siècle accompli, il est frappant de constater que la publication de ce premier numéro suivait de peu la survenue de trois événements qui allaient totalement bouleverser non seulement le champ de la médecine et des sciences relatif à la fertilité humaine, mais aussi le rapport des humains aux mystères de leur conception, de la détermination du sexe, et à leur environnement...
ISSN: 0767-0974

hal-00877251
https://hal.archives-ouvertes.fr/hal-00877251
https://hal.archives-ouvertes.fr/hal-00877251/document
https://hal.archives-ouvertes.fr/hal-00877251/file/La_infertilitA_mA_le_aujourda_hui-accepted.pdf
DOI : 10.1051/medsci/2012285001

Éditeur(s) : HAL CCSD
Résumé : International audience
The SOX8 and SOX9 transcription factors are involved in, among others, sex differentiation, male gonad development and adult maintenance of spermatogenesis. Sox8(-/-) mice lacking Sox9 in Sertoli cells fail to form testis cords and cannot establish spermatogenesis. Although genetic and histological data show an important role for these transcription factors in regulating spermatogenesis, it is not clear which genes depend upon them at a genome-wide level. To identify transcripts that respond to the absence of Sox8 in all cells and Sox9 in Sertoli cells we measured mRNA concentrations in testicular samples from mice at 0, 6 and 18 days post-partum. In total, 621 and 629 transcripts were found at decreased or increased levels, respectively, at different time points in the mutant as compared to the control samples. These mRNAs were categorized as preferentially expressed in Sertoli cells or germ cells using data obtained with male and female gonad samples and enriched testicular cell populations. Five candidate genes were validated at the protein level. Furthermore, we identified putative direct SOX8 and SOX9 target genes by integrating predicted SOX-binding sites present in potential regulatory regions upstream of the transcription start site. Finally, we used protein network data to gain insight into the effects on regulatory interactions that occur when Sox8 and Sox9 are absent in developing Sertoli cells. The integration of testicular samples with enriched Sertoli cells, germ cells and female gonads enabled us to broadly distinguish transcripts directly affected in Sertoli cells from others that respond to secondary events in testicular cell types. Thus, combined RNA profiling signals, motif predictions and network data identified putative SOX8/SOX9 target genes in Sertoli cells and yielded insight into regulatory interactions that depend upon these transcription factors. In addition, our results will facilitate the interpretation of genome-wide in vivo SOX8 and SOX9 DNA binding data.
Andrology

hal-00877013
https://hal.archives-ouvertes.fr/hal-00877013
DOI : 10.1111/j.2047-2927.2012.00049.x
PUBMED : 23315995

Éditeur(s) : HAL CCSD
Résumé : International audience
The relationships between Philodendron solimoesense and the larvae of two chalcid wasp species, inhabiting up to 88% of the infructescences, were studied in French Guiana. Exurus sp. (Chalcidoidea, Eulophidae, Tetrastichinae), is a gall maker and its larvae develop at the expense of seeds which are transformed into galls. We estimate that two seeds are necessary for the development of one eulophid. Their impact on plant reproductive success appears to be important, since parasitized fruits produce 60% fewer seeds than nonparasitized fruits and could explain the reduced seed set observed (53%). The larvae of a Sycophila sp. (Chalcidoidea, Eurytomidae, Eurytominae) are also present in the fruits of P. solimoesense occupied by eulophid larvae. The eurytomid larvae apparently develop at the expense of about one eulophid and are responsible for the death of 39% of them by direct predation or indirectly by consuming the gall tissues. Eulophids are far more abundant than eurytomids, since parasitized fruits contain an average of 11 eulophids but only one eurytomid. As chalcid wasp emergence takes place in a closed cavity and sex ratios are strongly biased in a given gall, local mate competition may occur as observed for fig wasps within figs.
International Journal of Plant Sciences

hal-01202708
https://hal.archives-ouvertes.fr/hal-01202708

Éditeur(s) : Soc Francaise D Ichtyologie
Résumé : Age is a necessary parameter used in population dynamics to assess the state of exploited resources. This parameter is poorly known for most deep-sea species (depth > 400 m). This work focused on age estimation from otoliths of Alepocephalus bairdii (Alepocephalidae), Coryphaenoides rupestris (Macrouridae), Helicolenus dactylopterus (Sebastidae) and Hoplostethus atlanticus (Trachichthyidae), which French fishery exploitation, off the west coasts of the British Isles, began the late 1980's. Considering otolith growth zones as annual, the four species all show high longevity: 38, 54, 43 and 130 years, respectively, together with slow growth. The differences in growth between sex were estimated and difficulties in accurately estimating the age were highlighted and showed the need to standardise and validate age estimation. The ages currently estimated for deep-sea fish must be used with caution.
Cybium (0399-0974) (Soc Francaise D Ichtyologie), 2000 , Vol. 24 , N. 3 , P. 7-16

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00000/10396/7690.pdf
http://archimer.ifremer.fr/doc/00000/10396/

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
The status of ethnic minority has been reported to be associated with a tendency toward sedentary behavior. The Guadeloupean population is composed of Afro-Caribbeans and an Asian Indian minority. This study examined the association of ethnicity and physical activity on the island. Energy expenditures (EE), energy intakes (EI), and macronutrient intakes of 122 Guadeloupean workers (60 Indians and 62 controls) were assessed by three consecutive 24-h recalls. Two-way analyses of variance were conducted to test the hypothesis of an effect of ethnicity, taking the potential effect of sex into account, on these variables. Asian Indians reported lower EE (P=0.011), lower EE/EI ratios (P=0.001), and lower physical activity (P=0.003) than their Afro-Carribean counterparts. Their food intakes were not different in terms of EI or macronutrient intake. No sex × ethnicity interactions were significant. The present study reports a tendency toward physical inactivity in Asian Indians of Guadeloupe associated with EI similar to those of controls. Sedentary lifestyles and energetic imbalances are well-documented risk factors for several diseases, including type 2 diabetes and cardiovascular disease, both major public health concerns in Guadeloupe. Strategies to prevent sedentary lifestyles should be considered for Asian Indian Guadeloupeans.
ISSN: 0905-7188

hal-00706161
https://hal.univ-antilles.fr/hal-00706161
DOI : 10.1111/j.1600-0838.2007.00743.x

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: HIV cohort collaborations, which pool data from diverse patient cohorts, have provided key insights into outcomes of antiretroviral therapy (ART). However, the extent of, and reasons for, between-cohort heterogeneity in rates of AIDS and mortality are unclear. METHODS: We obtained data on adult HIV-positive patients who started ART from 1998 without a previous AIDS diagnosis from 17 cohorts in North America and Europe. Patients were followed up from 1 month to 2 years after starting ART. We examined between-cohort heterogeneity in crude and adjusted (age, sex, HIV transmission risk, year, CD4 count and HIV-1 RNA at start of ART) rates of AIDS and mortality using random-effects meta-analysis and meta-regression. RESULTS: During 61 520 person-years, 754/38 706 (1.9%) patients died and 1890 (4.9%) progressed to AIDS. Between-cohort variance in mortality rates was reduced from 0.84 to 0.24 (0.73 to 0.28 for AIDS rates) after adjustment for patient characteristics. Adjusted mortality rates were inversely associated with cohorts' estimated completeness of death ascertainment [excellent: 96-100%, good: 90-95%, average: 75-89%; mortality rate ratio 0.66 (95% confidence interval 0.46-0.94) per category]. Mortality rate ratios comparing Europe with North America were 0.42 (0.31-0.57) before and 0.47 (0.30-0.73) after adjusting for completeness of ascertainment. CONCLUSIONS: Heterogeneity between settings in outcomes of HIV treatment has implications for collaborative analyses, policy and clinical care. Estimated mortality rates may require adjustment for completeness of ascertainment. Higher mortality rate in North American, compared with European, cohorts was not fully explained by completeness of ascertainment and may be because of the inclusion of more socially marginalized patients with higher mortality risk.
ISSN: 0300-5771

hal-00875138
https://hal.archives-ouvertes.fr/hal-00875138
DOI : 10.1093/ije/dys164
PUBMED : 23148105